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https://www.readbyqxmd.com/read/29792310/bet-inhibition-overcomes-receptor-tyrosine-kinase-mediated-cetuximab-resistance-in-hnscc
#1
Brandon Leonard, Toni M Brand, Rachel A O'Keefe, Eliot Lee, Yan Zang, Jacquelyn D Kemmer, Hua Li, Jennifer R Grandis, Neil E Bhola
Cetuximab, the FDA-approved anti-EGFR antibody for head and neck squamous cell carcinoma (HNSCC), has displayed limited efficacy due to the emergence of intrinsic and acquired resistance. We and others have demonstrated that cetuximab resistance in HNSCC is driven by alternative receptor tyrosine kinases (RTK) including HER3, MET, and AXL. In an effort to overcome cetuximab resistance and circumvent toxicities associated with the administration of multiple RTK inhibitors, we sought to identify a common molecular target that regulates expression of multiple RTK...
May 23, 2018: Cancer Research
https://www.readbyqxmd.com/read/29792112/analytical-and-computational-study-of-an-individual-based-network-model-for-the-spread-of-heavy-drinking
#2
Donald A French, Marisa Eisenberg, Tony Nance, Zeynep Teymuroglu
Two simple models for the spread of heavy drinking among a network of individuals are re-introduced and analysed. We provide theorems on the spread of alcohol abuse for these models in cases involving simple connection schemes. Indicators for this spread that resemble the [Formula: see text] used in disease assessment are suggested and studied. We further provide computations with our models on general application networks and begin to study the reliability of the spread indicators.
December 2018: Journal of Biological Dynamics
https://www.readbyqxmd.com/read/29790337/copper-i-usy-as-a-ligand-free-and-recyclable-catalyst-for-ullmann-type-o-n-s-and-c-arylation-reactions-scope-and-application-to-total-synthesis
#3
Tony Garnier, Mathieu Danel, Valentin Magne, Anthony Pujol, Valérie Beneteau, Patrick Pale, Stefan Chassaing
The copper(I)-doped zeolite CuI-USY proved to be a versatile, efficient, and recyclable catalyst for various Ullmann-type coupling reactions. Easy-to-prepare and cheap, this catalytic material enables the arylation and heteroarylation of diverse O-, N-, S- and C-nucleophiles under ligand-free conditions, while exhibiting large functional group compatibility. The facility of this catalyst to promote C-O bond formation was further demonstrated with the total synthesis of 3-methylobovatol, a naturally occurring diaryl ether of biological relevance...
May 23, 2018: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29789620/super-resolution-architecture-of-mammalian-centriole-distal-appendages-reveals-distinct-blade-and-matrix-functional-components
#4
T Tony Yang, Weng Man Chong, Won-Jing Wang, Gregory Mazo, Barbara Tanos, Zhengmin Chen, Thi Minh Nguyet Tran, Yi-De Chen, Rueyhung Roc Weng, Chia-En Huang, Wann-Neng Jane, Meng-Fu Bryan Tsou, Jung-Chi Liao
Distal appendages (DAPs) are nanoscale, pinwheel-like structures protruding from the distal end of the centriole that mediate membrane docking during ciliogenesis, marking the cilia base around the ciliary gate. Here we determine a super-resolved multiplex of 16 centriole-distal-end components. Surprisingly, rather than pinwheels, intact DAPs exhibit a cone-shaped architecture with components filling the space between each pinwheel blade, a new structural element we term the distal appendage matrix (DAM). Specifically, CEP83, CEP89, SCLT1, and CEP164 form the backbone of pinwheel blades, with CEP83 confined at the root and CEP164 extending to the tip near the membrane-docking site...
May 22, 2018: Nature Communications
https://www.readbyqxmd.com/read/29789472/the-impact-of-nutrition-and-health-claims-on-consumer-perceptions-and-portion-size-selection-results-from-a-nationally-representative-survey
#5
Tony Benson, Fiona Lavelle, Tamara Bucher, Amanda McCloat, Elaine Mooney, Bernadette Egan, Clare E Collins, Moira Dean
Nutrition and health claims on foods can help consumers make healthier food choices. However, claims may have a 'halo' effect, influencing consumer perceptions of foods and increasing consumption. Evidence for these effects are typically demonstrated in experiments with small samples, limiting generalisability. The current study aimed to overcome this limitation through the use of a nationally representative survey. In a cross-sectional survey of 1039 adults across the island of Ireland, respondents were presented with three different claims (nutrition claim = "Low in fat"; health claim = "With plant sterols...
May 22, 2018: Nutrients
https://www.readbyqxmd.com/read/29789239/mandatory-influenza-vaccination-and-religious-accommodation-for-healthcare-workers-lessons-from-recent-legal-challenges
#6
Y Tony Yang, Ross D Silverman
No abstract text is available yet for this article.
May 19, 2018: Vaccine
https://www.readbyqxmd.com/read/29789004/a-population-based-study-of-the-risk-of-osteoporosis-and-fracture-with-dutasteride-and-finasteride
#7
Tony Antoniou, Erin M Macdonald, Zhan Yao, Tara Gomes, Mina Tadrous, Joanne M-W Ho, Muhammad M Mamdani, David N Juurlink
BACKGROUND: Dutasteride is a potent inhibitor of 5-alpha reductase enzymes that reduces concentrations of dihydrotestosterone to a greater extent than finasteride. Whether this has adverse implications for bone health is unknown. We compared the risk of osteoporosis and fractures in older men treated with dutasteride or finasteride. METHODS: We conducted a population-based retrospective cohort study with high-dimensional propensity score matching of Ontario men aged 66 years or older who started treatment with dutasteride or finasteride between January 1, 2006 and December 31, 2012...
May 22, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29788906/influences-on-the-adoption-of-patient-safety-innovation-in-primary-care-a-qualitative-exploration-of-staff-perspectives
#8
Ian Litchfield, Paramjit Gill, Tony Avery, Stephen Campbell, Katherine Perryman, Kate Marsden, Sheila Greenfield
BACKGROUND: Primary care is changing rapidly to meet the needs of an ageing and chronically ill population. New ways of working are called for yet the introduction of innovative service interventions is complicated by organisational challenges arising from its scale and diversity and the growing complexity of patients and their care. One such intervention is the multi-strand, single platform, Patient Safety Toolkit developed to help practices provide safer care in this dynamic and pressured environment where the likelihood of adverse incidents is increasing...
May 22, 2018: BMC Family Practice
https://www.readbyqxmd.com/read/29788292/biological-processes-modulating-longevity-across-primates-a-phylogenetic-genome-phenome-analysis
#9
Gerard Muntané, Xavier Farré, Juan Antonio Rodríguez, Cinta Pegueroles, David A Hughes, João Pedro de Magalhães, Toni Gabaldón, Arcadi Navarro
Aging is a complex process affecting different species and individuals in different ways. Comparing genetic variation across species with their aging phenotypes will help understanding the molecular basis of aging and longevity. Although most studies on aging have so far focused on short-lived model organisms, recent comparisons of genomic, transcriptomic, and metabolomic data across lineages with different lifespans are unveiling molecular signatures associated with longevity. Here, we examine the relationship between genomic variation and maximum lifespan (MLS) across primate species...
May 21, 2018: Molecular Biology and Evolution
https://www.readbyqxmd.com/read/29786974/embryonic-exposure-to-environmentally-relevant-concentrations-of-a-brominated-flame-retardant-reduces-the-size-of-song-control-nuclei-in-a-songbird
#10
Margaret L Eng, Viktoria Winter, John E Elliott, Scott A MacDougall-Shackleton, Tony D Williams
Environmental contaminants have the potential to act as developmental stressors and impair development of song and the brain of songbirds, but they have been largely unstudied in this context. 2,2',4,4',5-Pentabromodiphenyl ether (BDE-99) is a brominated flame retardant congener that has demonstrated endocrine disrupting effects, and has pervaded the global environment. We assessed the effects of in ovo exposure to environmentally relevant levels of BDE-99 on the neuroanatomy of the song-control system in a model songbird species, the zebra finch (Taeniopygia guttata)...
May 22, 2018: Developmental Neurobiology
https://www.readbyqxmd.com/read/29786693/hormonebase-a-population-level-database-of-steroid-hormone-levels-across-vertebrates
#11
Maren N Vitousek, Michele A Johnson, Jeremy W Donald, Clinton D Francis, Matthew J Fuxjager, Wolfgang Goymann, Michaela Hau, Jerry F Husak, Bonnie K Kircher, Rosemary Knapp, Lynn B Martin, Eliot T Miller, Laura A Schoenle, Jennifer J Uehling, Tony D Williams
Hormones are central regulators of organismal function and flexibility that mediate a diversity of phenotypic traits from early development through senescence. Yet despite these important roles, basic questions about how and why hormone systems vary within and across species remain unanswered. Here we describe HormoneBase, a database of circulating steroid hormone levels and their variation across vertebrates. This database aims to provide all available data on the mean, variation, and range of plasma glucocorticoids (both baseline and stress-induced) and androgens in free-living and un-manipulated adult vertebrates...
May 22, 2018: Scientific Data
https://www.readbyqxmd.com/read/29784193/adjuvant-vascular-endothelial-growth-factor-targeted-therapy-in-renal-cell-carcinoma-a-systematic-review-and-pooled-analysis
#12
REVIEW
Maxine Sun, Lorenzo Marconi, Tim Eisen, Bernard Escudier, Rachel H Giles, Naomi B Haas, Lauren C Harshman, David I Quinn, James Larkin, Sumanta K Pal, Thomas Powles, Christopher W Ryan, Cora N Sternberg, Robert Uzzo, Toni K Choueiri, Axel Bex
CONTEXT: Contradictory data exist with regard to adjuvant vascular endothelial growth factor receptor (VEGFR)-targeted therapy in surgically managed patients for localized renal cell carcinoma (RCC). OBJECTIVE: To systematically evaluate the current evidence regarding the therapeutic benefit (disease-free survival [DFS] and overall survival [OS]) and grade 3-4 adverse events (AEs) for adjuvant VEGFR-targeted therapy for resected localized RCC. EVIDENCE ACQUISITION: A critical review of PubMed/Medline, Embase, and the Cochrane Library in January 2018 according to the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) statement was performed...
May 18, 2018: European Urology
https://www.readbyqxmd.com/read/29782355/inhibition-of-vascular-endothelial-cell-leak-following-escherichia-coli-attachment-in-an-experimental-model-of-sepsis
#13
Tony M McHale, Carolina D Garciarena, Robert P Fagan, Stephen G J Smith, Ignacio Martin-Loches, Gerard F Curley, Fidelma Fitzpatrick, Steve W Kerrigan
OBJECTIVES: The vascular endothelium is a major target of sepsis-induced events, and endothelial activation accounts for much of the pathology of sepsis. Urinary tract infections and pneumonia caused by Escherichia coli are among of the most common infections causing sepsis in both community and hospital settings. Currently, there are no approved drugs on the market to treat the underlying pathophysiology of sepsis. The aim of this study is to elucidate the molecular mechanism by which E...
May 18, 2018: Critical Care Medicine
https://www.readbyqxmd.com/read/29781564/non-steroidal-anti-inflammatory-drugs-reduce-the-time-to-recovery-of-gut-function-after-elective-colorectal-surgery-a-systematic-review-and-meta-analysis
#14
REVIEW
Tony Ge Milne, Rebekah Jaung, Gregory O'Grady, Ian P Bissett
BACKGROUND: Postoperative ileus causes significant patient morbidity after abdominal surgery. Some evidence suggests non-steroidal anti-inflammatory drugs (NSAIDs) may reduce time to gut recovery, but there has not been a meta-analysis to assess their efficacy. AIM: To determine the benefit of NSAIDs in patients undergoing elective colorectal surgery on recovery of post-operative gut function by systematic review and meta-analysis. METHODS: MEDLINE, EMBASE, CENTRAL and reference lists were searched with no date or language restrictions...
May 21, 2018: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/29780859/monoaminergic-impairment-in-down-syndrome-with-alzheimer-s-disease-compared-to-early-onset-alzheimer-s-disease
#15
Alain D Dekker, Yannick Vermeiren, Maria Carmona-Iragui, Bessy Benejam, Laura Videla, Ellen Gelpi, Tony Aerts, Debby Van Dam, Susana Fernández, Alberto Lleó, Sebastian Videla, Anne Sieben, Jean-Jacques Martin, Rafael Blesa, Juan Fortea, Peter P De Deyn
Introduction: People with Down syndrome (DS) are at high risk for Alzheimer's disease (AD). Defects in monoamine neurotransmitter systems are implicated in DS and AD but have not been comprehensively studied in DS. Methods: Noradrenaline, adrenaline, and their metabolite 3-methoxy-4-hydroxyphenylglycol (MHPG); dopamine and its metabolites 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid; and serotonin and its metabolite 5-hydroxyindoleacetic acid were quantified in 15 brain regions of DS without AD (DS, n = 4), DS with AD (DS+AD, n = 17), early-onset AD (EOAD, n = 11) patients, and healthy non-DS controls (n = 10) in the general population...
2018: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/29780497/the-development-of-a-novel-and-logic-based-fluorescence-probe-for-the-detection-of-peroxynitrite-and-gsh
#16
Adam C Sedgwick, Hai-Hao Han, Jordan E Gardiner, Steven D Bull, Xiao-Peng He, Tony D James
We have developed a novel AND logic based fluorescence probe for the simultaneous detection of ONOO- and GSH ( GSH-PF3 ). The GSH-PF3 probe was synthesised over three steps starting from commercially available fluorescein. The probe was constructed by attaching the GSH reactive motif, 2,4-dinitrobenzenesulfonyl, to the previously reported boronate fluorescence based probe, PF3 . GSH-PF3 produced only a small fluorescence response towards the addition of GSH or ONOO- separately. However, when the probe was exposed to both analytes, there was a significant (40-fold) fluorescence enhancement...
April 21, 2018: Chemical Science
https://www.readbyqxmd.com/read/29780429/balancing-stability-and-flexibility-in-adaptive-governance-an-analysis-of-tools-available-in-u-s-environmental-law
#17
Robin Kundis Craig, Ahjond S Garmestani, Craig R Allen, Craig Anthony Tony Arnold, Hannah Birgé, Daniel A DeCaro, Alexander K Fremier, Hannah Gosnell, Edella Schlager
Adaptive governance must work "on the ground," that is, it must operate through structures and procedures that the people it governs perceive to be legitimate and fair, as well as incorporating processes and substantive goals that are effective in allowing social-ecological systems (SESs) to adapt to climate change and other impacts. To address the continuing and accelerating alterations that climate change is bringing to SESs, adaptive governance generally will require more flexibility than prior governance institutions have often allowed...
June 30, 2017: Ecology and Society: a Journal of Integrative Science for Resilience and Sustainability
https://www.readbyqxmd.com/read/29779831/interleukin-6-significantly-improves-predictive-value-of-systemic-inflammatory-response-syndrome-for-predicting-severe-acute-pancreatitis
#18
Saransh Jain, Shallu Midha, Soumya Jagannath Mahapatra, Swatantra Gupta, Manish Kumar Sharma, Baibaswata Nayak, Tony George Jacob, Shalimar, Pramod Kumar Garg
BACKGROUND: Predicting severe acute pancreatitis (AP) is important for triage, prognosis, and designing therapeutic trials. Persistent systemic inflammatory response syndrome (SIRS) predicts severe AP but its diagnostic accuracy is suboptimal. Our objective was to study if cytokine levels could improve the predictive value of clinical variables for the development of severe AP. METHODS: Consecutive patients with AP were included in a prospective cohort study at a tertiary care center...
May 14, 2018: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/29779659/preparation-assay-and-application-of-chlorinase-sall-for-the-chemoenzymatic-synthesis-of-s-adenosyl-l-methionine-and-analogs
#19
Tony D Davis, Sylvia Kunakom, Michael D Burkart, Alessandra S Eustaquio
S-adenosyl-l-methionine (SAM) is universal in biology, serving as the second most common cofactor in a variety of enzymatic reactions. One of the main roles of SAM is the methylation of nucleic acids, proteins, and metabolites. Methylation often imparts regulatory control to DNA and proteins, and leads to an increase in the activity of specialized metabolites such as those developed as pharmaceuticals. There has been increased interest in using SAM analogs in methyltransferase-catalyzed modification of biomolecules...
2018: Methods in Enzymology
https://www.readbyqxmd.com/read/29779134/complexity-of-systems-and-actions-underlying-neurogenic-inflammation
#20
EDITORIAL
Tony L Yaksh, Anna Di Nardo
No abstract text is available yet for this article.
May 2018: Seminars in Immunopathology
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