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https://www.readbyqxmd.com/read/29141170/data-sharing-from-clinical-trials-a-research-funder-s-perspective
#1
Robert Kiley, Tony Peatfield, Jennifer Hansen, Fiona Reddington
New England Journal of Medicine, Volume 377, Issue 20, Page 1990-1992, November 2017.
November 16, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/29140636/trends-and-patterns-in-unintentional-injury-fatalities-in-australian-agriculture
#2
Tony Lower, Margaret Rolfe, Noeline Monaghan
Agriculture is recognized internationally as a hazardous industry. This article describes the trends and patterns of unintentional farm fatalities in Australia. Data from the National Coronial Information System were analyzed to assess all unintentional farm fatalities for the 2001-2015 period. A secondary comparison with earlier coronial system data from 1989-1992 was also completed to ascertain historical changes. There was no statistically significant change in the rate of work-related fatalities per 100,000 workers in the 2001-2015 period...
April 26, 2017: Journal of Agricultural Safety and Health
https://www.readbyqxmd.com/read/29140331/multi-wavelength-filtering-with-a-waveguide-integrated-phase-modulated-bragg-grating
#3
Somnath Paul, Toni Saastamoinen, Seppo Honkanen, Matthieu Roussey, Markku Kuittinen
We present a multi-wavelength band-rejection filter on a titanium dioxide-coated silicon-on-insulator platform. The concept rests on the use of a finely tuned waveguide-based Bragg grating for which the periods are slightly varied from one to another. This phase-modulated Bragg grating enables precise customization of integrated waveguide filters. The number of rejection bands and the center-to-center separation between them are tailored by dividing the grating into several super-periods and coding an optimal phase function onto each super-period...
November 15, 2017: Optics Letters
https://www.readbyqxmd.com/read/29138047/antibacterial-effect-and-dna-delivery-using-a-combination-of-an-arsonium-containing-lipophosphoramide-with-an-n-heterocyclic-carbene-silver-complex-potential-benefits-for-cystic-fibrosis-lung-gene-therapy
#4
Angélique Mottais, Mathieu Berchel, Yann Sibiril, Véronique Laurent, Deborah Gill, Stephen Hyde, Paul-Alain Jaffrès, Tristan Montier, Tony Le Gall
Cystic Fibrosis (CF), the most common chronic genetic disorder among the Caucasian population, is a life-threatening disease mainly due to respiratory failures resulting from chronic infections and inflammation. Although research in the pharmacological field has recently made significant progress, gene therapy still remains a promising strategy to cure CF, especially because it should be applicable to any patient whatever the mutation profile. Until now, little attention has been paid to bacterial lung infections with regard to gene delivery to the airways; yet, this could greatly impact on the success of gene therapy...
November 11, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29137630/diet-net-best-practice-guidelines-for-dietary-assessment-in-health-research
#5
Janet E Cade, Marisol Warthon-Medina, Salwa Albar, Nisreen A Alwan, Andrew Ness, Mark Roe, Petra A Wark, Katharine Greathead, Victoria J Burley, Paul Finglas, Laura Johnson, Polly Page, Katharine Roberts, Toni Steer, Jozef Hooson, Darren C Greenwood, Sian Robinson
BACKGROUND: Dietary assessment is complex, and strategies to select the most appropriate dietary assessment tool (DAT) in epidemiological research are needed. The DIETary Assessment Tool NETwork (DIET@NET) aimed to establish expert consensus on Best Practice Guidelines (BPGs) for dietary assessment using self-report. METHODS: The BPGs were developed using the Delphi technique. Two Delphi rounds were conducted. A total of 131 experts were invited, and of these 65 accepted, with 48 completing Delphi round I and 51 completing Delphi round II...
November 15, 2017: BMC Medicine
https://www.readbyqxmd.com/read/29137518/unlikely-surgeons-a-surgeon-in-the-village-an-american-doctor-teaches-brain-surgery-in-africa-by-tony-bartelme-boston-ma-beacon-press-2017-288-pp-27-95
#6
https://www.readbyqxmd.com/read/29137449/differential-side-effects-profile-in-patients-with-mcrpc-treated-with-abiraterone-or-enzalutamide-a-meta-analysis-of-randomized-controlled-trials
#7
REVIEW
Raphael B Moreira, Marcio Debiasi, Edoardo Francini, Pier V Nuzzo, Guillermo De Velasco, Fernando C Maluf, Andre P Fay, Joaquim Bellmunt, Toni K Choueiri, Fabio A Schutz
Background: Abiraterone and enzalutamide are currently approved for mCRPC patients. Both drugs have distinct mechanisms of action and may have different toxicity profile. There are limited data comparing the side effects of abiraterone and enzalutamide. We performed a meta-analysis of randomized controlled trials (RCT) to better characterize the risk of adverse events associated with both drugs. Methods: We performed a literature search on MEDLINE for studies reporting abiraterone and enzalutamide side effects from January 1966 to July 31, 2015...
October 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/29137185/a-cross-sectional-study-of-nutrient-intake-and-health-status-among-older-adults-in-yogyakarta-indonesia
#8
Tony Arjuna, Stijn Soenen, Rasita Amelia Hasnawati, Kylie Lange, Ian Chapman, Natalie D Luscombe-Marsh
Many communities around the world, particularly developing countries including Indonesia, are experiencing population ageing. There is little knowledge regarding the impact of malnutrition, or its prevalence within rural compared to urban areas, on the nutritional, functional and mental status of community-living older residents in these countries. Hence, a cross-sectional study was conducted to determine socio-demographic and anthropometric characteristics, nutritional, mental and functional status, and energy and nutrient intake of community-dwelling Indonesians from both rural and urban areas of Yogyakarta...
November 13, 2017: Nutrients
https://www.readbyqxmd.com/read/29137129/design-and-evaluation-of-novel-polymyxin-fluorescent-probes
#9
Bo Yun, Kade D Roberts, Philip E Thompson, Roger L Nation, Tony Velkov, Jian Li
Polymyxins (polymyxin B and colistin) are cyclic lipopeptide antibiotics that serve as a last-line defence against Gram-negative "superbugs". In the present study, two novel fluorescent polymyxin probes were designed through regio-selective modifications of the polymyxin B core structure at the N-terminus and the hydrophobic motif at positions 6 and 7. The resulting probes, FADDI-285 and FADDI-286 demonstrated comparable antibacterial activity (MICs 2-8 mg/L) to polymyxin B and colistin (MICs 0.5-8 mg/L) against a panel of gram-negative clinical isolates of Acinetobacter baumannii, Klebsiella pneumoniae and Pseudomonas aeruginosa...
November 11, 2017: Sensors
https://www.readbyqxmd.com/read/29137065/primary-leiomyosarcoma-of-the-bone-a-case-report-and-a-review-of-the-literature
#10
Federica Recine, Alberto Bongiovanni, Roberto Casadei, Federica Pieri, Nada Riva, Alessandro De Vita, Laura Mercatali, Chiara Liverani, Chiara Spadazzi, Giacomo Miserocchi, Valentina Fausti, Dino Amadori, Toni Ibrahim
RATIONALE: Leiomyosarcoma (LMS) is a malignant sarcoma that can occur in different anatomic sites, including the bone, showing similar histological characteristics but heterogeneous clinical behavior and prognosis. Primary bone LMS was first described in 1965. It is a very rare sarcoma, accounting for <0.7% of all primary malignant bone tumors. PATIENT CONCERNS: We report the case of a 52-year-old male with primary bone LMS who presented with a solitary osteolytic lesion with focal cortical destruction in the left clavicle, seen on an x-ray and subsequent computed tomography (CT) scan...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29137042/associations-among-medication-regimen-complexity-medical-specialty-and-medication-possession-ratio-in-newly-diagnosed-hypertensive-patients-a-population-based-study
#11
Chen-Pei Ho, Jih-I Yeh, Shu-Hui Wen, Tony Jer-Fu Lee
The aim of this study was to explore the associations among the medication regimen complexity index (MRCI), medical specialty, and medication possession ratio (MPR) in newly diagnosed hypertensive patients.Data from 19,859 newly diagnosed hypertensive patients were collected from 2,000,000 random samples of the National Health Insurance Research Database in Taiwan. All study participants were followed for 1 year after the first diagnosis of hypertension. MPR was defined as total days of antihypertensive drugs supplied/365 days...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29136514/rejection-sensitivity-interpersonal-rejection-and-attention-for-emotional-facial-expressions
#12
Morganne A Kraines, Lucas J A Kelberer, Tony T Wells
BACKGROUND AND OBJECTIVES: Rejection sensitivity (RS), attention for depression-relevant stimuli, and interpersonal rejection are established risk factors for depression. RS has previously been associated with increased attention for socially threatening faces, but has not been examined in the context of specifically depression-relevant stimuli. The current study examined whether RS influences attention for emotional facial expressions in the context of social rejection or inclusion. METHODS: Participants (n = 180) completed a self-report measure of RS and a free viewing eye tracking task before and after an experimental task (Cyberball) in which participants were randomized to be included or rejected...
November 8, 2017: Journal of Behavior Therapy and Experimental Psychiatry
https://www.readbyqxmd.com/read/29134206/azulene-boronate-esters-colorimetric-indicators-for-fluoride-in-drinking-water
#13
Carlos M López-Alled, Adrian Sanchez-Fernandez, Karen J Edler, Adam C Sedgwick, Steven D Bull, Claire L McMullin, Gabriele Kociok-Köhn, Tony D James, Jannis Wenk, Simon E Lewis
Low cost and in situ fluoride detection by non-experts is important for the determination of drinking water safety in developing countries. Colour reagents can provide results quickly without expensive equipment, but colorimetric fluoride indicators are often nonspecific, complex to use or do not work in water. Here we show that azulene-boronate indicators respond selectively to fluoride at concentrations relevant to the WHO limit of 1.5 mg L(-1).
November 14, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29133607/cardiovascular-outcomes-and-risks-after-initiation-of-a-sodium-glucose-co-transporter-2-inhibitor-results-from-the-easel-population-based-cohort-study
#14
Jacob A Udell, Zhong Yuan, Toni Rush, Nicholas M Sicignano, Michael Galitz, Norman Rosenthal
Background : Clinical trials have shown cardiovascular benefits and potential risks from sodium glucose co-transporter 2 inhibitors (SGLT2i). Trials may have limited ability to address individual endpoints or safety concerns. Methods : We performed a population-based cohort study among type 2 diabetes patients with established cardiovascular disease newly initiated on antihyperglycemic agents (AHAs) within the US Department of Defense Military Health System between 4/1/2013 and 12/31/2016. Incidence rates, hazard ratios (HRs), and 95% confidence intervals (CIs) for time to first composite endpoint of all-cause mortality (ACM) and hospitalization for heart failure (HHF) event, major adverse cardiovascular events (MACE; defined as ACM, nonfatal myocardial infarction, and nonfatal stroke), and individual endpoints were evaluated using conditional Cox models comparing new SGLT2i users with other AHAs...
November 13, 2017: Circulation
https://www.readbyqxmd.com/read/29133598/half-lives-of-pfos-pfhxs-and-pfoa-after-end-of-exposure-to-contaminated-drinking-water
#15
Ying Li, Tony Fletcher, Daniel Mucs, Kristin Scott, Christian H Lindh, Pia Tallving, Kristina Jakobsson
BACKGROUND: Municipal drinking water contaminated with perfluorinated alkyl acids had been distributed to one-third of households in Ronneby, Sweden. The source was firefighting foam used in a nearby airfield since the mid-1980s. Clean water was provided from 16 December 2013. OBJECTIVE: To determine the rates of decline in serum perfluorohexane sulfonate (PFHxS), perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA), and their corresponding half-lives...
November 13, 2017: Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/29133596/exposure-to-ambient-fine-particulate-matter-and-semen-quality-in-taiwan
#16
Xiang Qian Lao, Zilong Zhang, Alexis Kh Lau, Ta-Chien Chan, Yuan Chieh Chuang, Jimmy Chan, Changqing Lin, Cui Guo, Wun Kai Jiang, Tony Tam, Gerard Hoek, Haidong Kan, Eng-Kiong Yeoh, Ly-Yun Chang
OBJECTIVES: Environmental exposure to chemicals has been considered a potential factor contributing to deteriorated semen quality. However, previous literature on exposure to air pollution and semen quality is inconsistent. We therefore investigated the health effects of short-term and long-term exposure to fine particulate matter (PM2.5) on semen quality in Taiwanese men from the general population. METHODS: A cross-sectional study was conducted among 6475 male participants aged 15-49 years who participated in a standard medical examination programme in Taiwan between 2001 and 2014...
November 13, 2017: Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/29131778/adventures-and-misadventures-in-plastic-surgery-and-soft-tissue-implants
#17
Dana J Lin, Tony T Wong, Gina A Ciavarra, Jonathan K Kazam
Soft-tissue augmentation and implants are increasingly seen by the radiologist as more techniques emerge for a variety of indications and locations. Some surgical and implant procedures are performed for purely cosmetic reasons in otherwise healthy patients seeking to improve their body image, and some are performed for reconstruction after cancer or other chronic illnesses. Abdominoplasty, liposuction, and autologous fat grafting can be performed for abdominal and gluteal contouring. Injection of liquid injectable silicone has historically been fraught with legal issues, although it continues to be used for augmentation in a variety of anatomic locations...
November 2017: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/29131774/imaging-of-juvenile-hip-conditions-predisposing-to-premature-osteoarthritis-pediatric-imaging
#18
Carl Kraus, Rama S Ayyala, Jonathan K Kazam, Tony T Wong
No abstract text is available yet for this article.
November 2017: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/29131727/guidelines-for-teaching-yoga-to-women-with-breast-cancer-related-lymphoedema-an-evidence-based-approach
#19
Annette Loudon, Tony Barnett, Andrew D Williams, Denis Visentin, Maarten A Immink, Neil Piller
Breast cancer-related lymphoedema (BCRL) is a chronic condition that requires lifelong management to prevent the condition worsening and to reduce the threat of infection. Women are affected in all domains of their life. As a holistic practice, yoga may be of benefit by reducing both the physical and psychosocial effects of lymphoedema. Women with BCRL are attending yoga classes in increasing numbers, so it is essential that yoga be based on principles that ensure lymphoedema is controlled and not exacerbated...
November 2017: International Journal of Yoga Therapy
https://www.readbyqxmd.com/read/29131425/stage-of-diagnosis-of-prostate-breast-and-colorectal-cancer-in-farm-residents-compared-with-other-rural-and-urban-residents-in-new-south-wales
#20
Julie Depczynski, Timothy Dobbins, Bruce Armstrong, Tony Lower
OBJECTIVE: To determine if stage at diagnosis of prostate, breast and colorectal cancers differs between farm, rural non-farm and urban residents. DESIGN: Data linkage of baseline survey information from a large cohort study, with state cancer registry records from 2006 to 2009. SETTING: New South Wales, Australia. PARTICIPANTS: New South Wales residents enrolled in the 45 and Up Study cohort. MAIN OUTCOME MEASURES: Adjusted odds ratio of non-localised cancer stage was modelled using binary logistic regression, controlling for commonly known cancer risk factors...
November 13, 2017: Australian Journal of Rural Health
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