keyword
https://read.qxmd.com/read/38532550/evaluation-of-tadalafil-supplementation-on-the-neutrophil-lymphocyte-and-the-platelet-lymphocyte-ratios-in-patients-with-erectile-dysfunction-a-prospective-study
#1
JOURNAL ARTICLE
Sameh Fayek GamalEl Din, Nashaat Nabil Ismail, Hanan Hosni Moawad, Iten Mohamed Adel, Ahmad Motawi, Hisham Foaad
OBJECTIVES: We aimed to evaluate the effect of daily 5 mg tadalafil on the neutrophil/lymphocyte ratio (NLR) and the platelet/lymphocyte ratio (PLR) in patients with erectile dysfunction (ED). PATIENTS AND METHODS: 30 subjects with ED were given tadalafil as well as 30 subjects with ED who were not receiving tadalafil were recruited. 30 healthy individuals served as controls. RESULTS: Receiver operating characteristic curve (ROC) showed that the best cut off point of pre-treatment and post treatment NLR in the ED treatment group was found <1...
March 26, 2024: Urologia
https://read.qxmd.com/read/38529412/identification-and-validation-of-new-fatty-acid-metabolism-related-mechanisms-and-biomarkers-for-erectile-dysfunction
#2
JOURNAL ARTICLE
Yanfeng He, Changyi Liu, Zhongjie Zheng, Rui Gao, Haocheng Lin, Huiliang Zhou
BACKGROUND: Erectile dysfunction (ED) is a common condition affecting middle-aged and elderly men. AIM: The study sought to investigate differentially expressed fatty acid metabolism-related genes and the molecular mechanisms of ED. METHODS: The expression profiles of GSE2457 and GSE31247 were downloaded from the Gene Expression Omnibus database and merged. Differentially expressed genes (DEGs) between ED and normal samples were obtained using the R package limma...
February 2024: Sexual Medicine
https://read.qxmd.com/read/38527306/erectile-dysfunction-assessment-and-management-in-primary-care
#3
JOURNAL ARTICLE
Yingxian Natalie Ong, Yu Guang Tan, Dian Handayani, Choon How How
No abstract text is available yet for this article.
March 1, 2024: Singapore Medical Journal
https://read.qxmd.com/read/38526118/socioeconomic-inequality-in-prostate-cancer-diagnostics-primary-treatment-rehabilitation-and-mortality-in-sweden
#4
JOURNAL ARTICLE
Ulf Strömberg, Anders Berglund, Stefan Carlsson, Camilla Thellenberg Karlsson, Mats Lambe, Ingela Franck Lissbrant, Pär Stattin, Ola Bratt
We designed a nationwide study to investigate the association between socioeconomic factors (household income and education) and different aspects of prostate cancer care, considering both individual- and neighbourhood-level variables. Data were obtained from Prostate Cancer data Base Sweden (PCBaSe), a research database with data from several national health care registers including clinical characteristics and treatments for nearly all men diagnosed with prostate cancer in Sweden. Four outcomes were analysed: use of pre-biopsy magnetic resonance imaging (MRI) in 2018-2020 (n = 11,843), primary treatment of high-risk non-metastatic disease in 2016-2020 (n = 6633), rehabilitation (≥2 dispensed prescriptions for erectile dysfunction within 1 year from surgery in 2016-2020, n = 6505), and prostate cancer death in 7770 men with high-risk non-metastatic disease diagnosed in 2010-2016...
March 25, 2024: International Journal of Cancer. Journal International du Cancer
https://read.qxmd.com/read/38525459/alcohol-associated-sexual-dysfunction-how-much-is-the-damage
#5
JOURNAL ARTICLE
Bhupendra Yadav, Harpreet Singh Dhillon, Shibu Sasidharan, Gurpreet Kaur Dhillon
BACKGROUND: The existing literature on alcohol-induced sexual dysfunction has mainly deliberated on erectile dysfunction and premature ejaculation, ignoring other important domains of sexual dysfunctions (viz sexual pleasure, sexual desire, arousal, orgasmic function). This study was undertaken to assess the extent of alcohol-associated sexual dysfunction and to compare their severity with the severity of alcohol dependence in males. METHODS: A cross-sectional descriptive study design recruited 78 male patients and an assessment was conducted using the Changes in sexual functioning questionnaire male clinical version, International index of erectile function scale , Severity of Alcohol Dependence Questionnaire , Diagnostic and Statistical Manual of Mental Disorders-5 (DSM-5) and International Classification of Diseases-10 (ICD-10)...
2024: Medical Journal, Armed Forces India
https://read.qxmd.com/read/38525266/development-and-evaluation-of-sildenafil-glycyrrhizin-loaded-nanofibers-as-a-potential-novel-buccal-delivery-system-for-erectile-dysfunction
#6
JOURNAL ARTICLE
Ali A Alamer, Abdullah A Alshehri, Alhassan H Aodah, Fahad A Almughem, Hamzah A Alghmadi, Amer S Alali, Abdulrahman A Halwani, Mohammed Muqtader Ahmed, Essam A Tawfik
Erectile dysfunction (ED) is a growing health condition that needs safe and effective therapy. One of the main common treatments is sildenafil which is used in clinics for managing erectile dysfunction by enhancing the blood supply to the penis. In the current study, sildenafil was formulated as nanofibers and mixed with the root extract of Glycyrrhiza glabra (glycyrrhizin) as a natural sweetener to be administrated in the buccal cavity for enhanced drug bioavailability, rapid drug absorption and improved patient compliance...
May 2024: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://read.qxmd.com/read/38523905/extracorporeal-shockwave-therapy-of-the-perineum-for-male-patients-with-chronic-pelvic-pain-syndrome-a-pilot-study
#7
JOURNAL ARTICLE
Joe K C Lee, Terence Y X Law, Liang Shen, Gregory X W Pek, Qi Y Lim, Yi Q Tan, Jun Y Chia, Man K Li
BACKGROUND: Chronic pelvic pain syndrome (CPPS) is a complex condition that is often difficult to treat and may sometimes require a multidisciplinary team. Among the wide array of treatment options is extracorporeal shockwave therapy (ESWT). However, its role in CPPS remains controversial. The purpose of our study is to assess the efficacy and safety of ESWT of the perineum in male patients with CPPS. METHODS: Fourteen patients aged between 21 and 85 years were recruited in this single-center, single-arm prospective trial from October 2018 to October 2020...
March 2024: Prostate International
https://read.qxmd.com/read/38522706/poly-l-lactic-acid-gelatin-electrospun-membrane-loaded-bone-marrow-derived-mesenchymal-stem-cells-attenuate-erectile-dysfunction-caused-by-cavernous-nerve-injury
#8
JOURNAL ARTICLE
Daoyuan Hu, Chang Liu, Yunlong Ge, Lei Ye, Qiang Guo, Yuhang Xi, Wenliang Zhu, Dejuan Wang, Tao Xu, Jianguang Qiu
Radical prostatectomy (RP) can cause neurogenic erectile dysfunction (ED), which negatively affects the quality of life of patients with prostate cancer. Currently, there is a dearth of effective therapeutic strategies. Although stem cell therapy is promising, direct cell transplantation to injured cavernous nerves is constrained by poor cell colonization. In this study, poly-L-lactic acid (PLLA)/gelatin electrospun membranes (PGEM) were fabricated to load bone marrow-derived mesenchymal stem cells (BM-MSCs) as a patch to be placed on injured nerves to alleviate ED...
March 22, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38520608/research-advances-in-stem-cell-therapy-for-erectile-dysfunction
#9
REVIEW
Wei Wang, Ying Liu, Zuo-Bin Zhu, Kun Pang, Jing-Kai Wang, Jun Gu, Zhen-Bei Li, Jian Wang, Zhen-Duo Shi, Cong-Hui Han
Erectile dysfunction (ED) is a common clinical condition that mainly affects men aged over 40 years. Various causes contribute to the progression of ED, including pelvic nerve injury, diabetes, metabolic syndrome, age, Peyronie's disease, smoking, and psychological disorders. Current treatments for ED are limited to symptom relief and do not address the root cause. Stem cells, with their powerful ability to proliferate and differentiate, are a promising approach for the treatment of male ED and are gradually gaining widespread attention...
March 23, 2024: BioDrugs: Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy
https://read.qxmd.com/read/38520301/relationship-between-vitamin-d-receptors-gene-polymorphism-and-arteriogenic-erectile-dysfunction
#10
JOURNAL ARTICLE
Ahmed Rashad Elshahid, Amr Mohamed Zaky, Yasser Mamdouh Hasanein Goda, Nabil Fathy Ismail
BACKGROUND: Over the past few decades, a number of studies have linked vitamin-D deficiency with ED (Erectile dysfunction) risk factors. There is a clear correlation between VD (vitamin-D) levels and ED, according to observational and interventional researches that have been reported in the literature. This crucial information encouraged scientists to investigate the impact of VD on erectile function in greater detail. The fact that vitamin D is a component of a healthy penis that begins in early life has just come to light, however there haven't been many research looking at the connection between vitamin D receptor gene polymorphism and erectile dysfunction...
March 23, 2024: Urologia
https://read.qxmd.com/read/38519589/response-to-commentary-on-phosphodiesterase-type-5-inhibitors-do-not-prevent-curvature-progression-but-shorten-pain-duration-in-the-active-phase-of-peyronie-s-disease-a-retrospective-cohort-study
#11
JOURNAL ARTICLE
Emil Durukan, Christian Fuglesang Skjødt Jensen, Mikkel Fode
No abstract text is available yet for this article.
March 22, 2024: International Journal of Impotence Research
https://read.qxmd.com/read/38518238/assessment-of-the-treatment-effectiveness-of-men-with-mild-and-medium-degree-of-erectile-dysfunction
#12
JOURNAL ARTICLE
Volodymyr I Trishch, Andriy I Mysak, Andrii I Trishch, Andrii P Mandzii
OBJECTIVE: . Aim: To assess the effectiveness of monotherapy and complex treatment of patients with erectile dysfunction depending on its severity. PATIENTS AND METHODS: Materials and Methods: Men with moderate and mild erectile dysfunction took part in the study, who, in turn, were divided into groups, depending on the treatment, with the evaluation of the results of the International Index of Erectile Function (MIEF-15), the state of cavernous hemodynamics and the function of the vascular endothelium before and after treatment...
2024: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://read.qxmd.com/read/38516938/-minichal-and-items-predictors-of-worst-quality-of-life-in-men-with-arterial-hypertension
#13
JOURNAL ARTICLE
Mónica Diosdado Figueiredo
OBJECTIVE: Systemic arterial hypertension is the most important modificable risk factor for morbidity and mortality and a Public Health problem. The objective was to estímate ítems of worse quality of life (Qol) in both domains of the MINICHAL questionarie and the associated variables. METHODS: An observational study of prevalence in men was carried out. Sociodemographic, comorbidity, clinical, examination, control and serum parameters variables were collected...
March 22, 2024: Revista Española de Salud Pública
https://read.qxmd.com/read/38514868/comment-on-current-opinions-on-the-management-of-prolonged-ischemic-priapism-does-penoscrotal-decompression-outperform-corporoglanular-tunneling
#14
JOURNAL ARTICLE
Omer A Raheem, Marwan Alkassis, Rosemary Iwuala
No abstract text is available yet for this article.
March 21, 2024: International Journal of Impotence Research
https://read.qxmd.com/read/38509347/commentary-on-intermediate-term-results-of-tachosil-grafting-to-correct-residual-curvature-during-inflatable-penile-prosthesis-implantation-in-patients-with-peyronie-s-disease
#15
JOURNAL ARTICLE
Eric Chung, Nicholas Gillman
No abstract text is available yet for this article.
March 20, 2024: International Journal of Impotence Research
https://read.qxmd.com/read/38509346/accurate-diagnosis-and-effective-treatment-of-abnormal-meridians-in-erectile-dysfunction-patients-based-on-infrared-thermography-an-electrophysiological-technique-study
#16
JOURNAL ARTICLE
Wang Zihao, Liu Kaifeng, Zhang Shengmin, Gong Yongzhan, Lu Pengjie
An increasing body of research has demonstrated that appropriate stimulation of the meridians and acupoints in the human body can play a preventative and therapeutic role in diseases. This study combines the use of infrared thermography with intelligent electrophysiological diagnostic system (iEDS) to accurately diagnose and apply transdermal low-frequency electrical stimulation to treat abnormal meridians in patients with erectile dysfunction (ED). The treatment protocol included 6 treatments (each lasting 30 min and performed twice a week)...
March 20, 2024: International Journal of Impotence Research
https://read.qxmd.com/read/38507093/high-intensity-focused-ultrasound-with-visually-directed-power-adjustment-for-focal-treatment-of-localized-prostate-cancer-systematic-review-and-meta-analysis
#17
JOURNAL ARTICLE
Samuel J Peretsman, Mark Emberton, Neil Fleshner, Sunao Shoji, Clinton D Bahler, Larry E Miller
PURPOSE: To characterize patient outcomes following visually directed high-intensity focused ultrasound (HIFU) for focal treatment of localized prostate cancer. METHODS: We performed a systematic review of cancer-control outcomes and complication rates among men with localized prostate cancer treated with visually directed focal HIFU. Study outcomes were calculated using a random-effects meta-analysis model. RESULTS: A total of 8 observational studies with 1,819 patients (median age 67 years; prostate-specific antigen 7...
March 20, 2024: World Journal of Urology
https://read.qxmd.com/read/38506238/erectile-dysfunction-criteria-of-131-350-patients-after-open-laparoscopic-and-robotic-radical-prostatectomy
#18
JOURNAL ARTICLE
Tomás Bernardo Costa Moretti, Luís Alberto Magna, Leonardo Oliveira Reis
PURPOSE: Comparing post-radical prostatectomy erectile function rates among different techniques has always been a challenge in urology. This difficulty is due to the heterogeneity of studies, mainly in relation to the type of erectile function classification criteria used. The aim is to apply a new evidence-gathering methodology, called reverse systematic review, to compare erectile function rates among retropubic radical prostatectomy, laparoscopic radical prostatectomy, and robot-assisted radical prostatectomy, considering the diversity of classification criteria...
March 20, 2024: Andrology
https://read.qxmd.com/read/38505906/a-mendelian-randomization-study-on-causal-effects-of-leisure-sedentary-behavior-on-the-risk-of-erectile-dysfunction
#19
JOURNAL ARTICLE
Zhao Huangfu, Xinxin Gan, Yiren Yang, Qingyang Pang, Baohua Zhu, Xiao Zhang, Linhui Wang
BACKGROUND: Erectile dysfunction has been associated with leisure sedentary behavior in several epidemiological and observational studies. However, the interpretation of these findings is difficult due to residual confounding or reverse causality. OBJECTIVES: To explore the causal association between leisure sedentary behavior and erectile dysfunction, and to explore the underlying mechanism using Mendelian randomization. MATERIALS AND METHODS: In the present study, publicly available large-scale genome-wide association studies of leisure sedentary behaviors (television watching, computer use, and driving), erectile dysfunction, sex hormones (total testosterone, bioactive testosterone, estradiol, follicle-stimulating hormone, luteinizing hormone, prolactin, and sex hormone binding globulin), biomarkers of endothelial function (C reactive protein, E-selectin, and matrix metalloproteinase 7), and psychiatric symptoms (depression and anxiety) were used to perform two-sample Mendelian randomization analyses...
March 20, 2024: Andrology
https://read.qxmd.com/read/38505715/the-usefulness-of-shear-wave-elastography-in-evaluating-erectile-dysfunction-severity-before-and-after-prostaglandin-e1-test
#20
JOURNAL ARTICLE
Fumitoshi Sakamoto, Seiji Matsumoto, Toshikazu Otani, Yasuharu Takagi, Tokunori Yamamoto
Prostaglandin E1 intracavernous injection test is an established method for diagnosing erectile dysfunction. However, the evaluation is non-objective and often influenced by the evaluator's subjectivity. Herein, we measured and objectively evaluated shear wave elastography results of the corpus cavernosum before and after injection in 16 patients who underwent prostaglandin E1 testing. The response score of prostaglandin E1 tests were "1" in 2 cases, "2" in 2 cases, and "3" in 12 cases. The average transmission velocity before the injection and at the time of maximum erection after the injection were 2...
February 2024: Nagoya Journal of Medical Science
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