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https://www.readbyqxmd.com/read/29034101/lamotrigine-induced-sexual-dysfunction-and-non-adherence-case-analysis-with-literature-review
#1
Kenneth R Kaufman, Melissa Coluccio, Kartik Sivaraaman, Miriam Campeas
BACKGROUND: Optimal anti-epileptic drug (AED) treatment maximises therapeutic response and minimises adverse effects (AEs). Key to therapeutic AED treatment is adherence. Non-adherence is often related to severity of AEs. Frequently, patients do not spontaneously report, and clinicians do not specifically query, critical AEs that lead to non-adherence, including sexual dysfunction. Sexual dysfunction prevalence in patients with epilepsy ranges from 40 to 70%, often related to AEDs, epilepsy or mood states...
September 2017: BJPsych Open
https://www.readbyqxmd.com/read/29032115/toll-like-receptor-4-tlr4-impairs-nitric-oxide-contributing-to-angiotensin-ii-induced-cavernosal-dysfunction
#2
Kenia P Nunes, Gisele F Bomfim, Haroldo A Toque, Theodora Szasz, R Clinton Webb
AIM: Angiotensin II (AngII), a corpus cavernosum (CC) constrictor peptide, modulates Toll like receptor (TLR) expression, a key element of the innate immune system, contributing to impaired vascular function in pathological conditions. However, it is unknown whether TLR4 is involved in AngII-induced erectile dysfunction. In this study, we investigated whether TLR4 plays a role in cavernosal dysfunction caused by AngII upregulation. MATERIAL AND METHODS: Cavernosal smooth muscle cells (CSMC) from C57/BL6 mice were treated with AngII (0...
October 11, 2017: Life Sciences
https://www.readbyqxmd.com/read/29031427/-penile-prosthesis-implantation-indications-and-outcomes
#3
W Akakpo, K Ben-Naoum, D Carnicelli, L Ferretti, J-P Graziana, V Hupertan, E Huyghe, F X Madec, F Marcelli, C Methorst, N Morel-Journel, L Savareux, J E Terrier, R Yiou, A Faix
OBJECTIVE: Our aim was to present the indications and the outcomes of penile prosthesis implantation. METHODS: A literature review was performed through PubMed using the following keywords: penile implantation ; penile prosthesis; erectile dysfunction. RESULTS: Evolution of penile prosthesis devices led to get a fiable and effective treatment for men with erectile dysfunction who do not respond to less invasive therapy. Penile implant can also be useful in the treatment of Peyronie's disease, priapism and transgender surgery...
October 12, 2017: Progrès en Urologie
https://www.readbyqxmd.com/read/29031420/concordance-between-patient-reported-and-physician-reported-sexual-function-after-radical-prostatectomy
#4
Alan E Thong, Bing Ying Poon, Justin K Lee, Emily Vertosick, Daniel D Sjoberg, Andrew J Vickers, Behfar Ehdaie
PURPOSE: Accurately tracking health-related quality-of-life after radical prostatectomy is critical to counseling patients and improving technique. Physicians consistently overestimate functional recovery. We measured concordance between surgeon-assessed and patient-reported outcomes and evaluated a novel method to provide feedback to surgeons. MATERIALS AND METHODS: Men treated with radical prostatectomy self-completed the International Index of Erectile Function-6 questionnaire at each postoperative visit...
October 11, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/29030080/-effectiveness-of-pelvic-floor-rehabilitation-in-erectile-dysfunction-a-literature-review
#5
T Rival, L Clapeau
PURPOSE: The pelvic floor is now well known and its role in the mechanism of erection is demonstrated. We wanted to know what is the evidence of the effectiveness of perineal rehabilitation in erectile dysfunction. MATERIALS: An English search was performed in Google scholar and databases PubMed, Medline, Pedro with the keywords "pelvic floor, erectile dysfunction, impotence, physiotherapy, exercises, rehabilitation, PFMT". We have selected randomized clinical trials published in indexed journals...
October 10, 2017: Progrès en Urologie
https://www.readbyqxmd.com/read/29026497/methadone-replacement-therapy-and-sexual-disorders-among-opium-dependent-iranian-men-a-meta-analysis-study
#6
Masoudeh Babakhanian, Ali Akbar Haghdoost, Mahdi Afshari, Fatemeh Taghizadeh, Mahmood Moosazadeh
BACKGROUND: Evaluation of sexual disorders among persons receiving methadone replacement therapy is of great importance, because these problems may lead to non-compliance and relapse. This study aimed to estimate the effect of methadone maintenance therapy (MMT) on sexual function among addicted Iranian men using met-analysis. METHODS: Investigating the available data banks, relevant studies were identified. After exclusion of duplicates, irrelevant papers and low quality articles, eligible papers were entered into the meta-analysis...
January 2017: Addiction & Health
https://www.readbyqxmd.com/read/29021708/effects-of-ginseng-on-stress-related-depression-anxiety-and-the-hypothalamic-pituitary-adrenal-axis
#7
REVIEW
Seungyeop Lee, Dong-Kwon Rhee
Ginseng effectively regulates the immune response and the hormonal changes due to stress, thus maintaining homeostasis. In addition to suppressing the occurrence of psychological diseases such as anxiety and depression, ginseng also prevents stress-associated physiological diseases. Recent findings have revealed that ginseng is involved in adjusting the hypothalamic-pituitary-adrenal axis and controlling hormones, thus producing beneficial effects on the heart and brain, and in cases of bone diseases, as well as alleviating erectile dysfunction...
October 2017: Journal of Ginseng Research
https://www.readbyqxmd.com/read/29020765/insulin-resistance-is-an-independent-predictor-of-erectile-dysfunction-in-patients-with-gout
#8
Ji Hun Kim, Min Kyung Chung, Jin Young Kang, Jung Hee Koh, Jennifer Lee, Seung-Ki Kwok, Ji Hyeon Ju, Sung-Hwan Park
Background/Aims: Gout is associated with metabolic disorders that are important risk factors for cardiovascular disease and erectile dysfunction (ED). We aimed to identify independent predictors of ED in patients with gout. Methods: From August 2014 to August 2015, male outpatients who were being treated for gout in our rheumatology clinic and healthy males without any history of inflammatory disease (control group) were studied. ED was assessed in participants using the five-item version of the International Index of Erectile Function questionnaire...
October 12, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/29020139/coffee-intake-and-incidence-of-erectile-dysfunction
#9
David S Lopez, Lydia Liu, Eric B Rimm, Konstantinos K Tsilidis, Marcia de Oliveira Otto, Run Wang, Steven Canfield, Edward Giovannucci
Coffee intake is suggested to have a positive role against chronic diseases. Yet, the role of coffee in urological diseases such as erectile dysfunction (ED) remains unclear. Thus, we investigated the association of coffee intake with incidence of ED.A prospective analysis of 21,403 men aged 40-75 years old was conducted using the Health Professionals Follow-Up Study. Total coffee, regular and decaffeinated coffee intakes were self-reported on food-frequency questionnaires. ED was assessed by means of questionnaires in 2000, 2004 and 2008...
August 23, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28993731/small-and-intermediate-calcium-activated-potassium-channel-openers-improve-rat-endothelial-and-erectile-function
#10
Simon G Comerma-Steffensen, Ingrid Carvacho, Elise R Hedegaard, Ulf Simonsen
Modulation of endothelial calcium-activated potassium (KCa) channels has been proposed as an approach to restore endothelial function. The present study investigated whether novel openers of KCa channels with small (KCa2.x) and intermediate (KCa3.1) conductance, NS309 and NS4591, improve endothelium-dependent relaxation and erectile function. Rat corpus cavernosum (CC) strips were mounted for isometric tension recording and processed for immunoblotting. Mean arterial pressure (MAP), intracavernosal pressure (ICP), and electrocardiographic (ECG) measurements were conducted in anesthetized rats...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28993149/relationship-of-blood-pressure-and-erectile-dysfunction-in-men-without-previously-diagnosed-hypertension
#11
Arto Heikkilä, Antti Kaipia, Maarit Venermo, Hannu Kautiainen, Päivi Korhonen
BACKGROUND: Erectile dysfunction (ED) is the most common male sexual disorder that affects all age groups and has a close association with essential hypertension. AIM: To characterize the relation of blood pressure and ED in detail. METHODS: A cross-sectional population-based study of 45- to 70-year-old men without previously diagnosed hypertension, cardiovascular diseases, renal disease, or diabetes was conducted from 2005 to 2007 in southwestern Finland...
October 6, 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/28992374/male-accessory-gland-inflammation-infertility-and-sexual-dysfunctions-a-practical-approach-to-diagnosis-and-therapy
#12
REVIEW
A E Calogero, Y Duca, R A Condorelli, S La Vignera
The role of urogenital inflammation in causing infertility and sexual dysfunctions has long been a matter of debate in the international scientific literature. The most recent scientific evidences show that male accessory gland infection/inflammation could alter, with various mechanisms, both conventional and biofunctional sperm parameters, and determine worst reproductive outcome. At the same time, the high prevalence of erectile dysfunction and premature ejaculation in patients with male accessory gland infection/inflammation underlines the close link between these diseases and sexual dysfunctions...
October 9, 2017: Andrology
https://www.readbyqxmd.com/read/28982618/three-piece-penile-prosthesis-implantation-in-refractory-ischemic-priapism-tips-and-tricks
#13
Raul I Clavijo, Luís Felipe Sávio, Nachiketh Soodana Prakash, Thomas Masterson, J Francois Eid, Ranjith Ramasamy
INTRODUCTION AND OBJECTIVES: Implantation of a penile prosthesis in a patient with significant corporal fibrosis can pose a significant challenge to the surgeon, necessitating the knowledge of specific techniques used to dilate and close aggressively scarred corpora. The objective of our instructional video is to discuss 2 techniques used to approach corporal fibrosis: proper and safe use of cavernotomes for dilation and use of narrower prostheses. METHODS: In this video, we present a 53-year-old man with a history of priapism 3 years ago that lasted 4 days in the setting of trazodone use...
August 2017: Urology
https://www.readbyqxmd.com/read/28982319/sexual-dysfunction-in-epilepsy-and-the-role-of-anti-epileptic-drugs
#14
Mahinda Yogarajah, Marco Mula
BACKGROUND: Sexual dysfunction is very common in patients with epilepsy. OBJECTIVE: We sought to review the published literature around sexual dysfunction in epilepsy, and particularly the role played by anti-convulsant drugs. METHOD: We searched all related articles on PubMed using the search terms sexual dysfunction, various AEDs and epilepsy, and restricted the search to English language articles. RESULTS: The most common manifestations of sexual dysfunction in patients with epilepsy are hyposexuality and erectile dysfunction...
October 4, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28981625/frequency-of-and-factors-associated-with-sexual-dysfunction-in-patients-with-inflammatory-bowel-disease
#15
P Rivière, C Zallot, P Desobry, J M Sabaté, J Vergniol, F Zerbib, L Peyrin-Biroulet, D Laharie, F Poullenot
Background: Improvement of quality of life is a main objective in inflammatory bowel disease [IBD] management. Data on sexual dysfunction [SD] in IBD are scarce. This study compared rates of SD between IBD patients and healthy controls [HC], and searched for predictors of SD. Methods: All consecutive IBD patients seen in two tertiary centres during 2 months were invited to fill an anonymous validated questionnaire on their sexual function [Female Sexual Index Function and International Index of Erectile Function]...
July 22, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28979072/increased-risk-of-osteoporosis-in-depressive-patients-with-erectile-dysfunction-a-cross-sectional-study-from-malaysia
#16
Abdul Rahman Fata Nahas, Syed Azhar Syed Sulaiman
BACKGROUND: Depression imposes numerous changes on depressive men, promoting for low bone mineral density (BMD) and erectile dysfunction (ED), yet no published data on exploring the possible association between these two disorders among depressive men. We therefore investigated whether low BMD is associated with ED among depressive men and highlighted the possible mutual underlying factors that might give rise to these two disorders in this specific group of patients. MATERIALS AND METHODS: In this cross-sectional study, 119 depressive men were recruited and their sociodemographic and clinical characteristics were obtained...
July 2017: Journal of Pharmacy & Bioallied Sciences
https://www.readbyqxmd.com/read/28976401/-sexual-life-in-elderly-patients-with-cardiovascular-disease
#17
Hakan Karpuz
Sexual activity is an important component of patient and partner quality of life for men and women with cardiovascular disease, including many elderly patients. Older adults desire sexual intimacy when there is a partner and a health status that allows sexual relationships. Older individuals desire to love and enjoy sexual activity in relation to personal circumstances, and when health status allows them to experience close relations, most often within marriage especially in our country. Normal changes occur in the phases of sexual cycle with aging, male erectile dysfunction and female sexual dysfunction increase with age...
September 2017: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
https://www.readbyqxmd.com/read/28973402/2017-update-on-medical-overuse-a-systematic-review
#18
Daniel J Morgan, Sanket S Dhruva, Eric R Coon, Scott M Wright, Deborah Korenstein
Importance: Overuse of medical care is a well-recognized problem. Objective: To identify and highlight original research articles published in 2016 that are most relevant to understanding medical overuse or strategies to reduce it. Evidence Review: A structured review of English-language articles on PubMed published in 2016 coupled with examination of tables of contents of high-impact journals to identify articles related to medical overuse in adults...
October 2, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/28970082/identification-and-functional-verification-of-micrornas-in-the-obese-rat-with-erectile-dysfunction
#19
Yunlong Bai, Liangshuan Zhang, Yanan Jiang, Jiaming Ju, Guiyang Li, Juan Xu, Xing Jiang, Peng Zhang, Linchuan Lang, Olga Sadkovaya, Peter V Glybochko, Wei Zhang, Baofeng Yang
INTRODUCTION: Obesity is a potential risk factor for erectile dysfunction (ED). MicroRNAs (miRNAs) regulate the expression of genes involved in various pathophysiologic processes. AIM: To identify the miRNA profile in the corpus cavernosum (CC) of obese rats with ED and elucidate the potential function of miRNA in the pathogenesis of ED. METHODS: Obesity was induced in rats by a high-fat diet. After the erectile function test, experimental animals were divided into two groups: obese rats with ED and obese rats with normal erectile function...
September 29, 2017: Sexual Medicine
https://www.readbyqxmd.com/read/28969487/brain-structural-network-topological-alterations-of-the-left-prefrontal-and-limbic-cortex-in-psychogenic-erectile-dysfunction
#20
Jianhuai Chen, Yun Chen, Qingqiang Gao, Guotao Chen, Yutian Dai, Zhijian Yao, Qing Lu
Despite increasing understanding of the cerebral functional changes and structural abnormalities in erectile dysfunction, alterations in the topological organization of brain networks underlying psychogenic erectile dysfunction (pED) remain unclear. Here, based on the diffusion tensor image data of 25 pED patients and 26 healthy controls, we investigated the topological organization of brain structural networks and its correlations with the clinical variables using the graph theoretical analysis. Psychogenic ED displayed a preserved overall small-world organization and exhibited a less connectivity strength in the left inferior frontal gyrus, amygdale and the right inferior temporal gyrus...
October 2, 2017: International Journal of Neuroscience
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