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https://www.readbyqxmd.com/read/27871558/combipecs-the-single-injection-technique-of-pectoral-nerve-blocks-1-and-2-a-case-series
#1
Arunangshu Chakraborty, Rakhi Khemka, Taniya Datta, Suparna Mitra
Ultrasound-guided Pecs block can provide perioperative analgesia for breast surgery. A single-injection technique (COMBIPECS) combines both Pecs 1 and Pecs 2 blocks in a single needle pass. This technique saves time and is equally effective as the modified Pecs block which uses 2 needle passes. We present a case series of 21 patients who received the COMBIPECS block as a part of multimodal analgesia for breast cancer surgery. The block was administered before the surgery after induction of general anesthesia...
December 2016: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/27863288/broad-ion-beam-serial-section-tomography
#2
B Winiarski, A Gholinia, K Mingard, M Gee, G E Thompson, P J Withers
Here we examine the potential of serial Broad Ion Beam (BIB) Ar(+) ion polishing as an advanced serial section tomography (SST) technique for destructive 3D material characterisation for collecting data from volumes with lateral dimensions significantly greater than 100µm and potentially over millimetre sized areas. Further, the associated low level of damage introduced makes BIB milling very well suited to 3D EBSD acquisition with very high indexing rates. Block face serial sectioning data registration schemes usually assume that the data comprises a series of parallel, planar slices...
November 11, 2016: Ultramicroscopy
https://www.readbyqxmd.com/read/27829018/paravertebral-block-plus-thoracic-wall-block-versus-paravertebral-block-alone-for-analgesia-of-modified-radical-mastectomy-a-retrospective-cohort-study
#3
Nai-Liang Li, Ben-Long Yu, Chen-Fang Hung
BACKGROUND AND OBJECTIVES: Paravertebral block placement was the main anesthetic technique for modified radical mastectomy in our hospital until February 2014, when its combination with blocks targeting the pectoral musculature was initiated. We compared the analgesic effects of paravertebral blocks with or without blocks targeting the pectoral musculature for modified radical mastectomy. METHODS: We retrospectively collected data from a single surgeon and anesthesiologist from June 1, 2012, to May 31, 2015...
2016: PloS One
https://www.readbyqxmd.com/read/27817875/photoelectrochemical-cell-for-simultaneous-electricity-generation-and-heavy-metals-recovery-from-wastewater
#4
Dawei Wang, Yi Li, Gianluca Li Puma, Panagiotis Lianos, Chao Wang, Peifang Wang
The feasibility of simultaneous recovery of heavy metals from wastewater (e.g., acid mining and electroplating) and production of electricity is demonstrated in a novel photoelectrochemical cell (PEC). The photoanode of the cell bears a nanoparticulate titania (TiO2) film capped with the block copolymer [poly(ethylene glycol)-b-poly(propylene glycol)-b-poly(ethylene glycol)] hole scavenger, which consumed photogenerated holes, while the photogenerated electrons transferred to a copper cathode reducing dissolved metal ions and produced electricity...
February 5, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/27761032/ultrasound-guided-truncal-blocks-a-new-frontier-in-regional-anaesthesia
#5
Arunangshu Chakraborty, Rakhi Khemka, Taniya Datta
The practice of regional anaesthesia is rapidly changing with the introduction of ultrasound into the working domain of the anaesthesiologist. New techniques are being pioneered. Among the recent techniques, notable are the truncal blocks, for example, the transversus abdominis plane block, rectus sheath block, hernia block and quadratus lumborum block in the abdomen and the pectoral nerves (Pecs) block 1 and 2, serratus anterior plane block and intercostal nerve block. This narrative review covers the brief anatomical discourse along with technical description of the ultrasound-guided truncal blocks...
October 2016: Indian Journal of Anaesthesia
https://www.readbyqxmd.com/read/27676665/efficacy-and-safety-of-ketamine-added-to-local-anesthetic-in-modified-pectoral-block-for-management-of-postoperative-pain-in-patients-undergoing-modified-radical-mastectomy
#6
Ahmed H Othman, Ahmad M Abd El-Rahman, Fatma El Sherif
BACKGROUND: Breast surgery is an exceedingly common procedure with an increased incidence of acute and chronic pain. Pectoral nerve block is a novel peripheral nerve block alternative to neuro-axial and paravertebral blocks for ambulatory breast surgeries. OBJECTIVES: This study aims to compare the analgesic efficacy and safety of modified Pecs block with ketamine plus bupivacaine versus bupivacaine in patients undergoing breast cancer surgery. STUDY DESIGN: A randomized, double-blind, prospective study...
September 2016: Pain Physician
https://www.readbyqxmd.com/read/27543533/efficacy-of-pectoral-nerve-block-versus-thoracic-paravertebral-block-for-postoperative-analgesia-after-radical-mastectomy-a-randomized-controlled-trial
#7
S Kulhari, N Bharti, I Bala, S Arora, G Singh
BACKGROUND: Pectoral nerve (PecS) block is a recently introduced technique for providing surgical anaesthesia and postoperative analgesia during breast surgery. The present study was planned to compare the efficacy and safety of ultrasound-guided PecS II block with thoracic paravertebral block (TPVB) for postoperative analgesia after modified radical mastectomy. METHODS: Forty adult female patients undergoing radical mastectomy were randomly allocated into two groups...
September 2016: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/27124203/growth-and-photoelectrochemical-energy-conversion-of-wurtzite-indium-phosphide-nanowire-arrays
#8
Nikolay Kornienko, Natalie A Gibson, Hao Zhang, Samuel W Eaton, Yi Yu, Shaul Aloni, Stephen R Leone, Peidong Yang
Photoelectrochemical (PEC) water splitting into hydrogen and oxygen is a promising strategy to absorb solar energy and directly convert it into a dense storage medium in the form of chemical bonds. The continual development and improvement of individual components of PEC systems is critical toward increasing the solar to fuel efficiency of prototype devices. Within this context, we describe a study on the growth of wurtzite indium phosphide (InP) nanowire (NW) arrays on silicon substrates and their subsequent implementation as light-absorbing photocathodes in PEC cells...
May 24, 2016: ACS Nano
https://www.readbyqxmd.com/read/26934607/ultrasound-guided-serratus-anterior-plane-block-in-breast-reconstruction-surgery
#9
Rakhi Khemka, Arunangshu Chakraborty, Rosina Ahmed, Taniya Datta, Sanjit Agarwal
Pecs block and its variations have been used for various breast surgeries. We describe 2 cases of mastectomy and breast reconstruction by latissimus dorsi (LD) flap where regional analgesia was provided by a combination of ultrasound-guided Pecs-I block and serratus anterior plane block, a recently described technique in which local anesthetic is deposited in the plane between the LD and serratus anterior muscle. This resulted in excellent intraoperative and postoperative analgesia and a minimum of systemic analgesics...
May 1, 2016: A & A Case Reports
https://www.readbyqxmd.com/read/26052420/dye-sensitized-ps-b-p2vp-templated-nickel-oxide-films-for-photoelectrochemical-applications
#10
Julien Massin, Maximilian Bräutigam, Nicolas Kaeffer, Nicolas Queyriaux, Martin J Field, Felix H Schacher, Jürgen Popp, Murielle Chavarot-Kerlidou, Benjamin Dietzek, Vincent Artero
Moving from homogeneous water-splitting photocatalytic systems to photoelectrochemical devices requires the preparation and evaluation of novel p-type transparent conductive photoelectrode substrates. We report here on the sensitization of polystyrene-block-poly-(2-vinylpyridine) (PS-b-P2VP) diblock copolymer-templated NiO films with an organic push-pull dye. The potential of these new templated NiO film preparations for photoelectrochemical applications is compared with NiO material templated by F108 triblock copolymers...
June 6, 2015: Interface Focus
https://www.readbyqxmd.com/read/25411245/heterozygous-null-bone-morphogenetic-protein-receptor-type-2-mutations-promote-src-kinase-dependent-caveolar-trafficking-defects-and-endothelial-dysfunction-in-pulmonary-arterial-hypertension
#11
Allison R Prewitt, Sampa Ghose, Andrea L Frump, Arumima Datta, Eric D Austin, Anne K Kenworthy, Mark P de Caestecker
Hereditary pulmonary arterial hypertension (HPAH) is a rare, fatal disease of the pulmonary vasculature. The majority of HPAH patients inherit mutations in the bone morphogenetic protein type 2 receptor gene (BMPR2), but how these promote pulmonary vascular disease is unclear. HPAH patients have features of pulmonary endothelial cell (PEC) dysfunction including increased vascular permeability and perivascular inflammation associated with decreased PEC barrier function. Recently, frameshift mutations in the caveolar structural protein gene Caveolin-1 (CAV-1) were identified in two patients with non-BMPR2-associated HPAH...
January 9, 2015: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/24969515/hierarchical-tio2-cuins2-core-shell-nanoarrays-for-photoelectrochemical-water-splitting
#12
Keying Guo, Zhifeng Liu, Jianhua Han, Zhichao Liu, Yajun Li, Bo Wang, Ting Cui, Cailou Zhou
Hierarchical TiO2-CuInS2 core-shell nanoarrays were fabricated directly on conducting glass substrates (FTO) via facile and low-cost hydrothermal and polyol reduction methods for photoelectrochemical (PEC) water splitting using TiO2 branched nanorod arrays (BNRs) as the reactive framework. An enhanced optical property of the core-shell structure was discovered. Firstly, TiO2 BNRs-CuS core-shell structure was synthesized through successive ionic layer adsorption and reaction (SILAR). Subsequently, TiO2 BNRs-CuInS2 core-shell structure was derived from TiO2 BNRs-CuS core-shell structure...
August 14, 2014: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/24712388/entry-of-human-cytomegalovirus-into-porcine-endothelial-cells-depends-on-both-the-cellular-vascular-origin-and-the-viral-strain
#13
Aline Taveira, Nicolas Ponroy, Nicolas J Mueller, Anne-Laure Millard
BACKGROUND: Primary infection and reactivation of human cytomegalovirus (HCMV) is associated with allograft rejection. Pig-to-human xenotransplantation is regarded as an alternative to circumvent donor organ shortage and inevitably, porcine endothelial cells (pEC) will be exposed to human pathogens, among them HCMV. Infection of pEC with HCMV induces apoptosis and entry is sufficient to induce phenotypic alterations, which have the potential to result in rejection and vasculopathy. We investigated the mechanisms used by HCMV to enter pEC from different anatomical origins and compared them with the entry mechanisms used to enter human endothelial cells (hEC)...
July 2014: Xenotransplantation
https://www.readbyqxmd.com/read/24568166/facet-cutting-and-hydrogenation-of-in-2-o-3-nanowires-for-enhanced-photoelectrochemical-water-splitting
#14
Ming Meng, Xinglong Wu, Xiaobin Zhu, Xiaoshu Zhu, Paul K Chu
Semiconductor nanowires (NWs) are useful building blocks in optoelectronic, sensing, and energy devices and one-dimensional NWs have been used in photoelectrochemical (PEC) water splitting because of the enhanced light absorption and charge transport. It has been theoretically predicted that the {001} facets of body center cubic (bcc) In2O3 nanocrystals can effectively accumulate photogenerated holes under illumination, but it is unclear whether facet cutting of NWs can enhance the efficiency of PEC water splitting...
March 26, 2014: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/23989451/a-real-time-fluorescence-based-assay-for-measuring-%C3%AE-opioid-receptor-modulation-of-adenylyl-cyclase-activity-in-chinese-hamster-ovary-cells
#15
Alisa Knapman, Fe Abogadie, Peter McIntrye, Mark Connor
Inhibition of adenylyl cyclase (AC) activity is frequently used to measure µ-opioid receptor (MOR) activation. We sought to develop a simple, rapid assay of AC activity in whole cells that could be used to study MOR signaling. Chinese hamster ovary cells expressing human MOR (CHO-MOR cells) were grown in 96-well plates and loaded with membrane potential-sensitive fluorescent dye. CHO-MOR cells were treated with the AC activator forskolin (FSK), with or without simultaneous application of MOR agonists, and the resulting change in fluorescence was measured...
February 2014: Journal of Biomolecular Screening
https://www.readbyqxmd.com/read/22948973/induction-of-apoptosis-by-7-piperazinethylchrysin-in-hct-116-human-colon-cancer-cells
#16
Jie Ren, Hong Cheng, Wen Qun Xin, Xin Chen, Kun Hu
The antitumor activity of 7-piperazinethylchrysin (7-PEC) was investigated in HCT-116 human colon cancer cells. MTT assay revealed that the IC50 of 7-PEC in HCT-116 cells was 1.5 µM after 72 h of treatment, much lower than that of chrysin (>100 µM). The data showed that 7-PEC was able to inhibit the growth of HCT-116 cells in a concentration- and time-dependent manner. Topical morphological changes of apoptotic body formation after 7-PEC treatment were observed by Hoechst 33258 staining. 7-PEC reduced mitochondrial membrane potential (∆Ψm) of cells in a concentration-dependent manner and increased the production of intracellular reactive oxygen species (ROS)...
November 2012: Oncology Reports
https://www.readbyqxmd.com/read/22760074/fenoterol-functionally-activates-the-%C3%AE-%C3%A2-adrenoceptor-in-human-urinary-bladder-comparison-with-rat-and-mouse-implications-for-drug-discovery
#17
COMPARATIVE STUDY
Stefano Palea, Moèz Rekik, Céline Rouget, Philippe Camparo, Henri Botto, Pascal Rischmann, Philippe Lluel, Timothy D Westfall
Fenoterol has been reported to be a potent and selective β(2)-adrenoceptor agonist and is currently used clinically to treat asthma. Electrical field stimulation (EFS) of isolated urinary bladder mimics the voiding contraction by stimulating parasympathetic nerves, resulting in neurogenic contractions. To determine if stimulation of β(2)-adrenoceptors can inhibit this response, fenoterol was tested against EFS-induced contractions in human isolated urinary bladder and compared with mouse and rat. Bladder strips were mounted in organ baths and reproducible contractions induced by EFS...
September 5, 2012: European Journal of Pharmacology
https://www.readbyqxmd.com/read/22564647/the-interleukin-2-receptor-%C3%AE-chain-cd25-plays-an-important-role-in-regulating-monocyte-derived-cd40-expression-during-anti-porcine-cellular-responses
#18
Z-G Sun, Z Wang, L-M Zhu, Y-S Fang, L-Z Yu, H Xu
Long-term xenograft survival is limited by delayed xenograft rejection, and monocytes are thought to play an important role in this process. Although typically considered a T cell surface marker, interleukin 2 the receptor chain CD25 is also functional on monocytes. We hypothesized that CD25 expression on monocytes functions to augment monocyte activation in xeno-specific cellular responses. Xenogeneic mixed lymphocyte-endothelial cell reactions were used to study the role of CD25 in facilitating xenogeneic cell-mediated immune responses an in vitro...
May 2012: Transplantation Proceedings
https://www.readbyqxmd.com/read/22419425/analysis-of-the-mechanisms-underlying-the-vasorelaxant-action-of-coptisine-in-rat-aortic-rings
#19
Li-Li Gong, Lian-Hua Fang, Hai-Lin Qin, Yang Lv, Guan-Hua Du
The aim of the present study was to evaluate the vasorelaxant effects of coptisine and its possible mechanisms in isolated rat aortic rings. Coptisine was evaluated on isolated rat aortic rings precontracted with norepinephrine (NE) and KCl. The mechanisms were evaluated in the presence or absence of specific pharmacological inhibitors. Coptisine (1 ~ 200 μM) relaxed NE (1 μM) or KCl (60 mM) induced sustained contraction with pEC(50) values of 4.49 ± 0.48 and 4.85 ± 0.57 in a concentration dependent manner...
2012: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/22367785/inhibiting-nf-%C3%AE%C2%BAb-in-the-developing-lung-disrupts-angiogenesis-and-alveolarization
#20
Cristiana Iosef, Tero-Pekka Alastalo, Yanli Hou, Chihhsin Chen, Eloa S Adams, Shu-Chen Lyu, David N Cornfield, Cristina M Alvira
Bronchopulmonary dysplasia (BPD), a chronic lung disease of infancy, is characterized by arrested alveolar development. Pulmonary angiogenesis, mediated by the vascular endothelial growth factor (VEGF) pathway, is essential for alveolarization. However, the transcriptional regulators mediating pulmonary angiogenesis remain unknown. We previously demonstrated that NF-κB, a transcription factor traditionally associated with inflammation, plays a unique protective role in the neonatal lung. Therefore, we hypothesized that constitutive NF-κB activity is essential for postnatal lung development...
May 15, 2012: American Journal of Physiology. Lung Cellular and Molecular Physiology
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