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Primary cutaneous Ewing sarcoma

Ana M Molina-Ruiz, Klaus J Busam
No abstract text is available yet for this article.
September 2016: Journal of Cutaneous Pathology
Morgane Barreau, Jean-Marc Chevallier, Julien Pontoizeau, Céline Bazille, Céleste Lebbé, Laurence Verneuil, Anne Dompmartin
No abstract text is available yet for this article.
August 2016: International Journal of Dermatology
Rima A Safadi, Dima H Bader, Niveen I Abdullah, Maher A Sughayer
OBJECTIVE: To investigate the immunohistochemical expression (IHCE) of selected keratins in primary cutaneous and mucosal melanoma (pM), and metastatic melanoma (metsM) of the head and neck and to compare their expression to a group of undifferentiated/poorly differentiated tumors of the same anatomic region. STUDY DESIGN: IHCE of K6, K7, K8, K14, K16, K18, and K19 were studied in 29 melanomas and 70 cases of non-melanoma tumors of the same anatomic region (neuroendocrine carcinoma, neuroblastoma, olfactory neuroblastoma, sinonasal undifferentiated carcinoma, undifferentiated nasopharyngeal carcinoma, anaplastic large cell lymphoma, poorly differentiated squamous cell carcinoma (PDSCC), and Ewing sarcoma)...
May 2016: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Luca Grassetti, Matteo Torresetti, Donatella Brancorsini, Corrado Rubini, Davide Lazzeri, Giovanni Di Benedetto
INTRODUCTION: Primary cutaneous extraskeletal Ewing's sarcomas (ESs) are extremely rare tumors, limited to the skin and generally appear as a single small lesion, circumscribed mid-to-deep dermis or involving subcutis. Due to their rarity and morphological similarity to other cutaneous tumors, ESs are subject to being clinically and pathologically subdiagnosed. PRESENTATION OF CASE: A 37-year-old man presented a large rapidly growing mass of the first toe measuring 9...
2015: International Journal of Surgery Case Reports
Veronica Yuste, Elena Sierra, David Ruano, Mar Llamas-Velasco, Esther Conde, Daniel Azorin
Primary cutaneous Ewing's sarcoma is a rare entity. Although the diagnosis may be very difficult, it can be confirmed through molecular biology. We present the case of a 13-years old male with a lesion in the sole of the right foot, characterized by a monomorphous proliferation of small, round and blue cells. The histology and molecular biology allowed us to perform the diagnosis of cutaneous Ewing's sarcoma. This neoplasm must be distinguished from other round cell tumors with cutaneous involvement. The prognosis and treatment of this rare disease will also be discussed...
2015: Fetal and Pediatric Pathology
Angela Di Giannatale, Anna Maria Frezza, Marie-Cécile Le Deley, Perrine Marec-Bérard, Charlotte Benson, Jean-Yves Blay, Binh Bui, Ian Judson, Odile Oberlin, Jeremy Whelan, Nathalie Gaspar
BACKGROUND: Primary cutaneous/subcutaneous Ewing sarcoma (scEWS) is extremely rare. We describe clinical features, treatment, and outcome of this Ewing localization. PROCEDURE: Retrospective study (1996-2012) on 56 patients. RESULTS: Most primary scEWS occurred in late adolescent/young adult females (F/M = 1.9; median age 21.5 years), with primary tumor in the extremity/trunk (48.5%/39%). Only 35/56 samples had Real-Time-Polymerase-Chain-Reaction/Fluorescent-In-Situ-Hybridization analysis, 32/35 had EWS-translocation...
September 2015: Pediatric Blood & Cancer
Serhat Tanık, Kürşad Zengin, Sebahattin Albayrak, Recep Eryılmaz, Deniz Yılmaz, Necip Pirinçci
INTRODUCTION: Testicular cancer has high cure rates, especially after the adjuvant use of chemotherapy. Secondary tumors may develop months and years after the primary tumor. We aimed to report a case of cutaneous Ewing's sarcoma at the site of surgery 3 years after BEP chemotherapy. PRESENTATION OF CASE: 21 year old male underwent radical orchiectomy in 2008. After one year surgical site complaints brought him to same hospital. A limited surgical resection was made...
2014: International Journal of Surgery Case Reports
Jayme de Oliveira Filho, Ana Carolina Franco Tebet, Anna Rita Ferrante Mitidieri de Oliveira, Kassila Nasser
Ewing sarcoma is a primitive neuroectodermal tumor rarely occurs in the skin and sobcutaneous tissues. Generally Ewing's sarcoma is a primary bone tumor, but when present in soft tissues it characterizes an extremely uncommon clinical picture. It usually involves the deep subcutaneous tissue or muscles, and more rarely occurs like a primary skin cancer. Most patients are white, women, and in the second decade of life. The clinical features are a superficial mass, in average measuring 2-3 cm, of soft consistency, freely mobile and sometimes painful...
May 2014: Anais Brasileiros de Dermatologia
Angel Fernandez-Flores, Jose M Suarez-Peñaranda, Soledad Alonso
Merkel cell carcinoma (MCC) and primary cutaneous Ewing sarcoma/primitive neuroectodermal tumors (PCES/PNET) pose a challenging morphologic differential diagnosis. Approximately 90% of Ewing sarcoma/primitive neuroectodermal tumors (PNETs) have a specific translocation, t(11;22) (q24;q12). The EWS-friend leukemia integration-1 (FLI-1) fusion results in FLI-1 overexpression. EWS/FLI-1 rearrangement has been suggested as a useful tool in the diagnosis of PCES/PNET. In contrast, Merkel cell polyomavirus was found to be an infective agent related to the pathogenesis of MCC...
October 2013: Applied Immunohistochemistry & Molecular Morphology: AIMM
M Delaplace, C Lhommet, G de Pinieux, B Vergier, A de Muret, L Machet
BACKGROUND: Despite intensive treatment, the overall prognosis of Ewing sarcoma of the bone remains poor. Primary cutaneous Ewing sarcoma very rarely occurs and the prognosis has been reported to be better in some small series. All cases of Ewing sarcoma are currently treated in the same way, regardless of their location. OBJECTIVES: To determine whether Ewing sarcoma of the bone and primary cutaneous Ewing sarcoma are different in terms of epidemiology and prognosis...
April 2012: British Journal of Dermatology
M Delaplace, P Mélard, A Perrinaud, C Goré, B Vergier, L Machet
BACKGROUND: Ewing's sarcoma (or peripheral neuroectodermal tumour) is generally found in bone tissue, and a primary dermal site is extremely rare. We report a case of primary cutaneous Ewing's sarcoma in a 21-year-old woman. PATIENTS AND METHODS: A 21-year-old woman presented with a scapular lesion that had been slowly developing for one year. The 1-cm lesion was removed and histological examination showed proliferation of small round cells in the dermis. Immunostaining revealed cytoplasmic membrane expression of CD99 and a negative immunoprofile for other small round-cell tumors...
May 2011: Annales de Dermatologie et de Vénéréologie
Marleen Renard, Stefan Suciu, Yves Bertrand, Anne Uyttebroeck, Alice Ferster, Jutte van der Werff Ten Bosch, Françoise Mazingue, Emannuel Plouvier, Alain Robert, Patrick Boutard, Frédéric Millot, Martine Munzer, Françoise Mechinaud, Brigitte Lescoeur, Liliana Baila, Els Vandecruys, Yves Benoit, Pierre Philippet et al.
BACKGROUND: Intensive chemotherapy has markedly improved the survival of children with acute lymphoblastic leukaemia (ALL) or lymphoblastic lymphoma (LL). Evaluation of late effects and analysis of factors contributing to their occurrence has become of major importance. Second neoplasm (SN) belongs to the most severe late events. PROCEDURE: We report the incidence of SN which occurred in patients recruited in EORTC trial 58881 for children with ALL or LL. The front-line treatment regimen was adapted from the BFM protocol, but did not include cranial radiotherapy, even in patients with initial involvement of the central nervous system...
July 15, 2011: Pediatric Blood & Cancer
Sonali Kalra, Ruchika Gupta, Sompal Singh, Kusum Gupta, Madhur Kudesia
BACKGROUND: Extraskeletal Ewing's sarcoma (ES) was first recognized as a soft tissue tumor in 1975. Primacy cutaneous occurrence of Ewing's sarcoma/primitive neuroectodermnal tumor (ES/PNET) has been reported in only 31 cases so far. To the best of our knowledge, there is no report of preoperative cytologic diagnosis of cutaneous ES/PNET in the available literature except for this one. CASE: A young adult presented with a recurrent swelling on the medial aspect of the left leg that had been present for the past 5 years...
March 2010: Acta Cytologica
Won-Jong Bahk, Eun-Deok Chang, Jung Min Bae, Kyung-Ah Chun, An-Hee Lee, Sang-Young Rho, Jin Woo Kim
Extraskeletal Ewing's sarcoma (ES) and primitive neuroectodermal tumor (PNET) are widely regarded as clinically and histologically identical tumors which consist of small blue round cells. Extraskeletal ESs/PNETs usually occur in the deep soft tissues of the paraspinal region, chest wall, or lower extremities. However, superficially located cases, so-called cutaneous ESs/PNETs, are exceedingly rare, and the vast majority of the reported cases present as a single small mass. We present magnetic resonance imaging (MRI) findings and clinical course of a unique case of primary cutaneous ES/PNET presenting as numerous huge masses with severe ulceration on them...
June 2010: Skeletal Radiology
M V Shingde, M Buckland, K J Busam, S W McCarthy, J Wilmott, J F Thompson, R A Scolyer
AIMS: To perform a clinicopathological analysis of a series of primary cutaneous Ewing sarcomas/primitive neuroectodermal tumours (ES/PNET) to highlight the pathological features, discuss the differential diagnosis, emphasise the role of molecular testing (particularly fluorescence in situ hybridisation, FISH) in diagnosis and outline the patients' clinical course. METHODS: Seven cases of primary cutaneous ES/PNET were identified from the authors' consultation files...
October 2009: Journal of Clinical Pathology
Daniel Buxton, Carlos E Bacchi, Gabriela Gualco, Lawrence M Weiss, Craig W Zuppan, Edward H Rowsell, Qin Huang, Jun Wang
Originally described as a diagnostically useful marker for Ewing sarcoma, CD99 immunoreactivity has also been documented in a variety of other tumors, including hematopoietic neoplasms. By using conventional paraffin immunoperoxidase staining and tissue microarrays, we retrospectively investigated CD99 expression in a series of 160 anaplastic large cell lymphoma (ALCL) cases. Of the 160 cases, 103 (64.4%) were positive for CD99. The distribution of CD99 positivity was similar for nodal (66/103 [64.1%]), extranodal, (21/32 [66%]), and primary cutaneous lesions (16/25 [64%])...
April 2009: American Journal of Clinical Pathology
Peter D Inskip, Rochelle E Curtis
The objectives of our study were to quantify risks for developing new malignancies among childhood cancer survivors, identify links between particular types of first and subsequent cancer, and evaluate the possible role of treatment. A cohort of 25,965 2-month survivors of childhood cancer diagnosed in the U.S. during 1973-2002 was identified and followed through SEER cancer registries. Observed-to-expected ratios (O/E) were calculated, and Poisson regression was used to compare risks among treatment groups...
November 15, 2007: International Journal of Cancer. Journal International du Cancer
Torsten Ehrig, Steven D Billings, Julie C Fanburg-Smith
Primitive neuroectodermal tumor/Ewing sarcoma (PN/ES) is a single clinical, morphologic, and molecular small round cell tumor entity. These are generally found in deep soft tissue or bone of young male patients, with poor behavior. Location in dermis is unexpected; only rare cases are reported. Cases coded as "dermal," "cutaneous," or "skin" PN/ES were retrieved from our consultation files. Only primary dermal cases were included. Those otherwise diagnosed or with incomplete material were excluded. There were 13 dermal PN/ES cases, consisting of 10 women and 3 men...
June 2007: Annals of Diagnostic Pathology
Anne E Wilkerson, Meriden A Glasgow, Kim M Hiatt
BACKGROUND: CD99, also known as p30/32, is a glycoprotein product of the MIC2 gene. It was originally utilized in immunohistochemistry as a unique marker for Ewing sarcoma, other primitive neuroectodermal tumors, and subsequently in other tumors. Its expression in malignant melanoma (MM) has not been well documented, with just two isolated cases of MM recently reported. Recent studies have documented CD99 expression in a significant percentage of atypical fibroxanthomas (AFX), posing potential diagnostic problems in differentiating these two entities...
October 2006: Journal of Cutaneous Pathology
Hideaki Ishii, Takashi Joshita, Nagahisa Matsuyama, Takashi Uchida, Akio Ishikawa, Yoshiro Ebihara
We report a tumor in an 80-year-old man that was difficult to distinguish from other tumors, i.e., small cell carcinoma of the lung, PNET/Ewing tumor, malignant lymphoma, or malignant melanoma (amelanotic), and which was finally identified as cutaneous neuroendocrine carcinoma using immunohistochemical and ultrastructural methods. Autopsy did not show any tumors in the lungs, excluding the possibility of small cell carcinoma of the lung. Immunohistochemistry tests gave negative results for LCA, UCHL-1, CD3, and CD20, thereby excluding malignant lymphoma, and the negative results for S-100 protein and HMB-45 ruled out malignant melanoma...
September 2006: Medical Molecular Morphology
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