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https://www.readbyqxmd.com/read/28719527/pupillometry-guided-intraoperative-remifentanil-administration-versus-standard-practice-influences-opioid-use-a-randomized-study
#1
Nada Sabourdin, Jérôme Barrois, Nicolas Louvet, Agnès Rigouzzo, Marie-Laurence Guye, Christophe Dadure, Isabelle Constant
BACKGROUND: Pupillometry has shown promising results for assessing nociception in anesthetized patients. However, its benefits in clinical practice are not demonstrated. The aim of this prospective randomized study was to evaluate the impact of intraoperative pupillometry monitoring on perioperative opioid consumption in major gynecologic surgery. METHODS: After receiving ethics committee approval and written consent of patients, American Society of Anesthesiologists status I to II women undergoing gynecologic surgery were included in this single-blinded, prospective, parallel-arm randomized study...
August 2017: Anesthesiology
https://www.readbyqxmd.com/read/28719292/malaria-infection-and-gametocyte-carriage-rates-in-preparation-for-transmission-blocking-vaccine-trials-in-bancoumana-mali
#2
Mahamadoun Hamady Assadou, Issaka Sagara, Sara A Healy, Merepen Agnes Guindo, Mamady Kone, Sintry Sanogo, M'Bouye Doucoure, Sekouba Keita, Ruth D Ellis, Yimin Wu, Freda Omaswa, Patrick E Duffy, Ogobara K Doumbo
The epidemiological characterization of transmission reservoirs is a critical step in preparation for interventional trials for malaria elimination/eradication. Using cluster sampling and households/compounds as units of sampling, we recruited and followed monthly, from June 2011 to June 2012, 250 volunteers 3 months to 50 years of age in Bancoumana, Mali. In July 2012, only participants 5-35 years of age (N = 121) were reenrolled and followed for an additional year. Malaria infection prevalence was highest in October in both 2011 (21...
July 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28719240/cytoprotective-effects-of-essential-oil-of-pinus-halepensis-l-against-aspirin-induced-toxicity-in-iec-6-cells
#3
Hafsia Bouzenna, Najla Hfaiedh, Mouhamed Bouaziz, Marie-Agnès Giroux-Metges, Abdelfattah Elfeki, Hélène Talarmin
CONTEXT: Essential oils from Pinus species have been reported to have various therapeutic properties. OBJECTIVE: This study was undertaken to identify the chemical composition and cytoprotective effects of the essential oil of Pinus halepensis L. against aspirin-induced damage in cells in vitro. MATERIAL AND METHODS: The cytoprotection of the oil against toxicity of aspirin on the small intestine epithelial cells IEC-6 was tested. RESULTS: The obtained results have shown that 35 different compounds were identified...
July 18, 2017: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/28718130/%C3%A2-arztbudgets-abschaffen-pkv-und-gkv-st%C3%A3-rken%C3%A2
#4
Marie-Agnes Strack-Zimmermann
No abstract text is available yet for this article.
July 2017: MMW Fortschritte der Medizin
https://www.readbyqxmd.com/read/28717955/occurrence-of-spirocerca-lupi-infection-in-hungarian-dogs-referred-for-gastroscopy
#5
Roland Psáder, Márton Balogh, Kinga Pápa, Ágnes Sterczer, Zoltán Lukács, Andrea Harnos
No abstract text is available yet for this article.
July 17, 2017: Parasitology Research
https://www.readbyqxmd.com/read/28716444/thiosemicarbazone-derivatives-thiazolyl-hydrazones-effectively-inhibit-leukemic-tumor-cell-growth-down-regulation-of-ribonucleotide-reductase-activity-and-synergism-with-arabinofuranosylcytosine
#6
Geraldine Graser-Loescher, Agnes Schoenhuber, Caroline Ciglenec, Sabine Eberl, Georg Krupitza, Robert M Mader, Surender Singh Jadav, Venkatesan Jayaprakash, Monika Fritzer-Szekeres, Thomas Szekeres, Philipp Saiko
Cellular growth inhibition exerted by thiosemicarbazones is mainly attributed to down-regulation of ribonucleotide reductase (RNR) activity, with RNR being responsible for the rate-limiting step of de novo DNA synthesis. In this study, we investigated the antineoplastic effects of three newly synthesized thiosemicarbazone derivatives, thiazolyl hydrazones, in human HL-60 promyelocytic leukemia cells. The cytotoxicity of compounds alone and in combination with arabinofuranosylcytosine (AraC) was determined by growth inhibition assays...
July 14, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28716380/erratum-to-human-liver-regeneration-in-advanced-cirrhosis-is-organized-by-the-portal-tree-j-hepatol-66-2017-778-786
#7
Katalin Dezső, András Rókusz, Edina Bugyik, Armanda Szücs, András Szuák, Bence Dorogi, Mátyás Kiss, Ágnes Nemeskéri, Péter Nagy, Sándor Paku
No abstract text is available yet for this article.
August 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28715436/use-of-water-turnover-method-to-measure-mother-s-milk-flow-in-a-rat-model-application-to-dams-receiving-a-low-protein-diet-during-gestation-and-lactation
#8
Thomas Sevrin, Marie-Cécile Alexandre-Gouabau, Dominique Darmaun, Antoine Palvadeau, Agnès André, Patrick Nguyen, Khadija Ouguerram, Clair-Yves Boquien
Assessment of milk production is of utmost relevance for pediatricians and scientists interested in early life nutrition. The weight-suckle-weight (WSW) method, which consists of weighing babies before and after they suckle their mother, uses the difference in body weight as an estimate of milk intake. However, this is prone to many sources of error. In the current study, we used for the first time the water turnover method and compartmental analysis with deuterated water (D2O) as a non-toxic tracer to quantify in vivo milk production in a rat model...
2017: PloS One
https://www.readbyqxmd.com/read/28715247/comprehensive-reporting-in-cost-effectiveness-modeling
#9
Ágnes Benedict, Apoorva Ambavane, Ahmad Tarhini
No abstract text is available yet for this article.
July 17, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28715139/uvb-exposure-of-a-humanized-skin-model-reveals-unexpected-dynamic-of-keratinocyte-proliferation-and-wnt-inhibitor-balancing
#10
Teresa Michalczyk, Thomas Biedermann, Sophie Böttcher-Haberzeth, Agnes S Klar, Martin Meuli, Ernst Reichmann
We developed human dermo-epidermal skin substitutes which are presently applied in phase I and II clinical trials. Here we used these very same skin equivalents containing melanocytes, named MelSkin, as an experimental skin model. We investigated the effects of UVB irradiation on the skin grafts transplanted on immune-compromised rats. The irradiation induces a strong wound healing response going along with massive proliferation of basal keratinocytes, basically quiescent under non-irradiated, homeostatic conditions...
July 17, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28715095/a-self-sacrificing-n-methyltransferase-is-the-precursor-of-the-fungal-natural-product-omphalotin
#11
Sascha Ramm, Bartlomiej Krawczyk, Agnes Mühlenweg, Annette Poch, Eva Mösker, Roderich D Süssmuth
Research on ribosomally synthesized and posttranslationally modified peptides (RiPPs) has led to an increasing understanding of biosynthetic mechanisms, mostly drawn from bacterial examples. In contrast, reports on RiPPs from fungal producers, apart from the amanitins and phalloidins, are still scarce. The fungal cyclopeptide omphalotin A carries multiple N-methylations on the peptide backbone, a modification previously known only from nonribosomal peptides. Mining the genome of the omphalotin-producing fungus for a precursor peptide led to the identification of two biosynthesis genes, one encoding a methyltransferase OphMA that catalyzes the automethylation of its C-terminus, which is then released and cyclized by the protease OphP...
July 17, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28714557/concise-review-developing-best-practice-models-for-the-therapeutic-use-of-extracellular-vesicles
#12
REVIEW
Agnes T Reiner, Kenneth W Witwer, Bas W M van Balkom, Joel de Beer, Chaya Brodie, Randolph L Corteling, Susanne Gabrielsson, Mario Gimona, Ahmed G Ibrahim, Dominique de Kleijn, Charles P Lai, Jan Lötvall, Hernando A Del Portillo, Ilona G Reischl, Milad Riazifar, Carlos Salomon, Hidetoshi Tahara, Wei Seong Toh, Marca H M Wauben, Vicky K Yang, Yijun Yang, Ronne Wee Yeh Yeo, Hang Yin, Bernd Giebel, Eva Rohde, Sai Kiang Lim
Growing interest in extracellular vesicles (EVs, including exosomes and microvesicles) as therapeutic entities, particularly in stem cell-related approaches, has underlined the need for standardization and coordination of development efforts. Members of the International Society for Extracellular Vesicles and the Society for Clinical Research and Translation of Extracellular Vesicles Singapore convened a Workshop on this topic to discuss the opportunities and challenges associated with development of EV-based therapeutics at the preclinical and clinical levels...
July 17, 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28714338/antiplasmodial-prenylated-flavanonols-from-tephrosia-subtriflora
#13
Lois M Muiva-Mutisya, Yoseph Atilaw, Matthias Heydenreich, Andreas Koch, Hoseah M Akala, Agnes C Cheruiyot, Matthew L Brown, Beatrice Irungu, Faith A Okalebo, Solomon Derese, Charles Mutai, Abiy Yenesew
The CH2Cl2/MeOH (1:1) extract of the aerial parts of Tephrosia subtriflora afforded a new flavanonol, named subtriflavanonol (1), along with the known flavanone spinoflavanone B, and the known flavanonols MS-II (2) and mundulinol. The structures were elucidated by the use of NMR spectroscopy and mass spectrometry. The absolute configuration of the flavanonols was determined based on quantum chemical ECD calculations. In the antiplasmodial assay, compound 2 showed the highest activity against chloroquine-sensitive Plasmodium falciparum reference clones (D6 and 3D7), artemisinin-sensitive isolate (F32-TEM) as well as field isolate (KSM 009) with IC50 values 1...
July 16, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28713801/an-evaluation-of-a-train-the-trainer-workshop-for-social-service-workers-to-develop-community-based-family-interventions
#14
Agnes Y Lai, Sunita M Stewart, Moses W Mui, Alice Wan, Carol Yew, Tai Hing Lam, Sophia S Chan
INTRODUCTION: Evaluation studies on train-the-trainer workshops (TTTs) to develop family well-being interventions are limited in the literature. The Logic Model offers a framework to place some important concepts and tools of intervention science in the hands of frontline service providers. This paper reports on the evaluation of a TTT for a large community-based program to enhance family well-being in Hong Kong. METHODS: The 2-day TTT introduced positive psychology themes (relevant to the programs that the trainees would deliver) and the Logic Model (which provides a framework to guide intervention development and evaluation) for social service workers to guide their community-based family interventions...
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/28712854/c5-nephritic-factors-drive-the-biological-phenotype-of-c3-glomerulopathies
#15
Maria-Chiara Marinozzi, Sophie Chauvet, Moglie Le Quintrec, Morgane Mignotet, Florent Petitprez, Christophe Legendre, Mathilde Cailliez, Georges Deschenes, Michel Fischbach, Alexandre Karras, Francois Nobili, Christine Pietrement, Marie-Agnes Dragon-Durey, Fadi Fakhouri, Lubka T Roumenina, Veronique Fremeaux-Bacchi
C3 Glomerulopathies, which include Dense Deposit Disease and C3 Glomerulonephritis, are associated with genetic and acquired dysregulation of the C3 convertase alternative pathway of complement. The potential role of the activation of the C5 convertase has not been studied extensively. Here we analyzed IgG samples from patients with C3 Glomerulopathies to identify circulating autoantibodies that stabilize the C3 alternative pathway (C3 Nephritic Factors) as well as C5 convertases (C5 Nephritic Factors), thus preventing decay of these enzyme complexes...
July 13, 2017: Kidney International
https://www.readbyqxmd.com/read/28711235/assessing-improving-and-utilizing-sleep-in-high-risk-neonates
#16
Jeroen Dudink, Agnes van den Hoogen
No abstract text is available yet for this article.
July 12, 2017: Early Human Development
https://www.readbyqxmd.com/read/28709950/characterization-of-potent-and-selective-iodonium-class-inhibitors-of-nadph-oxidases
#17
Jiamo Lu, Prabhakar Risbood, Charles T Kane, Md Tafazzal Hossain, Larry Anderson, Kimberly Hill, Anne Monks, Yongzhong Wu, Smitha Antony, Agnes Juhasz, Han Liu, Guojian Jiang, Erik Harris, Krishnendu Roy, Jennifer L Meitzler, Mariam Konaté, James H Doroshow
The NADPH oxidases (NOXs) play a recognized role in the development and progression of inflammation-associated disorders, as well as cancer. To date, several NOX inhibitors have been developed, through either high throughput screening or targeted disruption of NOX interaction partners, although only a few have reached clinical trials. To improve the efficacy and bioavailability of the iodonium class NOX inhibitor diphenylene iodonium (DPI), we synthesized 36 analogs of DPI, focusing on improved solubility and functionalization...
July 11, 2017: Biochemical Pharmacology
https://www.readbyqxmd.com/read/28709898/development-of-a-duplex-taqman-real-time-pcr-assay-for-rapid-identification-of-vibrio-splendidus-related-and-v-aestuarianus-strains-from-bacterial-cultures
#18
Denis Saulnier, Sophie De Decker, Delphine Tourbiez, Marie Agnès Travers
To enable the rapid and accurate identification of Vibrio splendidus-related and V. aestuarianus strains associated with Pacific cupped oyster Crassostrea gigas mortality, we developed a duplex Taqman real-time PCR assay and evaluated its efficacy. This technique proved to be rapid, sensitive, and specific and will be particularly valuable for epidemiologic studies.
July 12, 2017: Journal of Microbiological Methods
https://www.readbyqxmd.com/read/28709637/tubulointerstitial-fibrosis-can-sensitize-the-kidney-to-subsequent-glomerular-injury
#19
Beom Jin Lim, Jae Won Yang, Jun Zou, Jianyong Zhong, Taiji Matsusaka, Ira Pastan, Ming-Zhi Zhang, Raymond C Harris, Hai-Chun Yang, Agnes B Fogo
Chronic glomerular injury is associated with eventual development of tubulointerstitial fibrosis. Here we aimed to assess whether, and how, mild chronic tubulointerstitial injury affects glomeruli. For this, we generated mice expressing different toxin receptors, one on their proximal tubular epithelial cells (diphtheria toxin receptor [DTR]) and the other only on podocytes (human CD25 [IL-2R] driven by the nephrin promoter [Nep25]), allowing serial induction of tubule-specific and glomerular (podocyte)-specific injury, respectively...
July 12, 2017: Kidney International
https://www.readbyqxmd.com/read/28709211/combustion-instability-mitigation-by-magnetic-fields
#20
Agnes Jocher, Heinz Pitsch, Thomas Gomez, Jérôme Bonnety, Guillaume Legros
The present interdisciplinary study combines electromagnetics and combustion to unveil an original and basic experiment displaying a spontaneous flame instability that is mitigated as the non-premixed sooting flame experiences a magnetic perturbation. This magnetic instability mitigation is reproduced by direct numerical simulations to be further elucidated by a flow stability analysis. A key role in the stabilization process is attributed to the momentum and thermochemistry coupling that the magnetic force, acting mainly on paramagnetic oxygen, contributes to sustain...
June 2017: Physical Review. E
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