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https://www.readbyqxmd.com/read/28813536/tuberculosis-patients-in-an-indian-mega-city-where-do-they-live-and-where-are-they-diagnosed
#1
Ramnath Subbaraman, Beena E Thomas, Senthil Sellappan, Chandra Suresh, Lavanya Jayabal, Savari Lincy, Agnes L Raja, Allison McFall, Sunil Suhas Solomon, Kenneth H Mayer, Soumya Swaminathan
OBJECTIVE: Tuberculosis (TB) is a major source of mortality in urban India, with many structural challenges to optimal care delivery. In the government TB program in Chennai, India's fourth most populous city, there is a 49% gap between the official number of smear-positive TB patients diagnosed and the official number registered in TB treatment within the city in 2014. We hypothesize that this "urban registration gap" is partly due to rural patients temporarily visiting the city for diagnostic evaluation...
2017: PloS One
https://www.readbyqxmd.com/read/28813530/urban-and-peri-urban-family-based-pig-keeping-in-cambodia-characteristics-management-and-perceived-benefits-and-constraints
#2
Gunilla Ström, Agnes Andersson Djurfeldt, Sofia Boqvist, Ann Albihn, Seng Sokerya, Sorn San, Holl Davun, Ulf Magnusson
Keeping pigs in urban and peri-urban areas may not only provide many benefits for the urban households, but may also be challenging and a potential health hazard. The aim of this cross-sectional study was to describe household characteristics and to evaluate perceived benefits and constraints among pig-keepers in the urban and peri-urban areas of Phnom Penh, Cambodia. The study included 204 households and a structured questionnaire was used to interview the household member responsible for taking care of the pigs...
2017: PloS One
https://www.readbyqxmd.com/read/28812841/university-of-global-health-equity-s-contribution-to-the-reduction-of-education-and-health-services-rationing
#3
EDITORIAL
Agnes Binagwaho
The inadequate supply of health workers and demand-side barriers due to clinical practice that heeds too little attention to cultural context are serious obstacles to achieving universal health coverage and the fulfillment of the human rights to health, especially for the poor and vulnerable living in remote rural areas. A number of strategies have been deployed to increase both the supply of healthcare workers and the demand for healthcare services. However, more can be done to improve service delivery as well as mitigate the geographic inequalities that exist in this field...
May 29, 2017: International Journal of Health Policy and Management
https://www.readbyqxmd.com/read/28812377/a-cross-sectional-study-of-coping-resources-and-mental-health-of-chinese-older-adults-in-the-united-states
#4
Man Guo, Nadia Sabbagh Steinberg, Xinqi Dong, Agnes Tiwari
OBJECTIVES: This study examined the potential influence of coping resources at individual (sense of mastery), family (spousal and family support, children's filial piety), and community levels (community cohesion) on the mental health (depression, anxiety) of U.S. Chinese older adults. METHODS: The data were derived from the Population Study of Chinese Elderly in Chicago (N= 3,159). Negative binomial regressions were performed to predict depression and anxiety, respectively, by entering the three sets of coping resources separately and jointly, controlling for socio-demographic and acculturation variables...
August 16, 2017: Aging & Mental Health
https://www.readbyqxmd.com/read/28811610/antibiotic-induced-release-of-small-extracellular-vesicles-exosomes-with-surface-associated-dna
#5
Andrea Németh, Norbert Orgovan, Barbara W Sódar, Xabier Osteikoetxea, Krisztina Pálóczi, Katalin É Szabó-Taylor, Krisztina V Vukman, Ágnes Kittel, Lilla Turiák, Zoltán Wiener, Sára Tóth, László Drahos, Károly Vékey, Robert Horvath, Edit I Buzás
Recently, biological roles of extracellular vesicles (which include among others exosomes, microvesicles and apoptotic bodies) have attracted substantial attention in various fields of biomedicine. Here we investigated the impact of sustained exposure of cells to the fluoroquinolone antibiotic ciprofloxacin on the released extracellular vesicles. Ciprofloxacin is widely used in humans against bacterial infections as well as in cell cultures against Mycoplasma contamination. However, ciprofloxacin is an inducer of oxidative stress and mitochondrial dysfunction of mammalian cells...
August 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28811493/fragile-temporal-prediction-in-patients-with-schizophrenia-is-related-to-minimal-self-disorders
#6
Brice Martin, Nicolas Franck, Michel Cermolacce, Agnès Falco, Anabel Benair, Estelle Etienne, Sébastien Weibel, Jennifer T Coull, Anne Giersch
Patients with schizophrenia have difficulty in making sensory predictions, in the time domain, which have been proposed to be related to self-disorders. However experimental evidence is lacking. We examined both voluntary and automatic forms of temporal prediction in 28 patients and 24 matched controls. A visual cue predicted (temporal cue) or not (neutral cue) the time (400 ms/1000 ms) at which a subsequent target was presented. In both patients and controls, RTs were faster for targets presented after long versus short intervals due to the temporal predictability inherent in the elapse of time ("hazard function")...
August 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28811303/adaptive-camouflage-what-can-be-learned-from-the-wetting-behaviour-of-the-tropical-flat-bugs-dysodius-lunatus-and-dysodiusmagnus
#7
Florian Hischen, Vladislav Reiswich, Desirée Kupsch, Ninon De Mecquenem, Michael Riedel, Markus Himmelsbach, Agnes Weth, Ernst Heiss, Oskar Armbruster, Johannes Heitz, Werner Baumgartner
The neotropical flat bug species Dysodius lunatus and Dysodius magnus show a fascinating camouflage principle, as their appearance renders the animal hardly visible on the bark of trees. However, when getting wet due to rain, bark changes its colour and gets darker. In order to keep the camouflage effect, it seems that some Dysodius species benefit from their ability to hold a water film on their cuticle and therefore change their optical properties when also wetted by water. This camouflage behaviour requires the insect to have a hydrophilic surface and passive surface structures which facilitate the liquid spreading...
August 15, 2017: Biology Open
https://www.readbyqxmd.com/read/28811236/interleukin-26-is-overexpressed-in-beh%C3%A3-et-s-disease-and-enhances-th17-related-cytokines
#8
Wajih Kaabachi, Eya Bouali, Anissa Berraïes, Imen Ben Dhifallh, Besma Hamdi, Kamel Hamzaoui, Agnès Hamzaoui
Behçet's disease (BD) is a multi-systemic inflammatory disorder characterized by the "triple symptom complex". Several pro-inflammatory cytokines, mainly derived from the immune Th17 axis, seem to be involved in different pathogenic pathways leading to development of the clinical manifestations. Here, we have analyzed the expression and role of IL-26 in active BD patients, an inflammatory disorder characterized by bronchoalveolar lavage fluid (BAL) and in cerebrospinal fluid (CSF) inflammation. On this basis, the primary aim of our work was to study IL-26 levels in serum, BAL CSF) from active BD patients...
August 12, 2017: Immunology Letters
https://www.readbyqxmd.com/read/28807996/klhl6-deficiency-impairs-transitional-b-cell-survival-and-differentiation
#9
Barbara Bertocci, Damiana Lecoeuche, Delphine Sterlin, Julius Kühn, Baptiste Gaillard, Annie De Smet, Frederique Lembo, Christine Bole-Feysot, Nicolas Cagnard, Tatiana Fadeev, Auriel Dahan, Jean-Claude Weill, Claude-Agnès Reynaud
Klhl6 belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. Several of these proteins function as adaptors of the Cullin3 E3 ubiquitin ligase complex. In this article, we report that Klhl6 deficiency induces, as previously described, a 2-fold reduction in mature B cells. However, we find that this deficit is centered on the inability of transitional type 1 B cells to survive and to progress toward the transitional type 2 B cell stage, whereas cells that have passed this step generate normal germinal centers (GCs) upon a T-dependent immune challenge...
August 14, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28807858/host-specificity-pathogen-exposure-and-superinfections-impact-the-distribution-of-anaplasma-phagocytophilum-genotypes-in-ticks-roe-deer-and-livestock-in-a-fragmented-agricultural-landscape
#10
Amélie Chastagner, Angélique Pion, Hélène Verheyden, Bruno Lourtet, Bruno Cargnelutti, Denis Picot, Valérie Poux, Émilie Bard, Olivier Plantard, Karen D McCoy, Agnes Leblond, Gwenaël Vourc'h, Xavier Bailly
Anaplasma phagocytophilum is a bacterial pathogen mainly transmitted by Ixodes ricinus ticks in Europe. It infects wild mammals, livestock, and, occasionally, humans. Roe deer are considered to be the major reservoir, but the genotypes they carry differ from those that are found in livestock and humans. Here, we investigated whether roe deer were the main source of the A. phagocytophilum genotypes circulating in questing I. ricinus nymphs in a fragmented agricultural landscape in France. First, we assessed pathogen prevalence in 1837 I...
August 11, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/28807243/is-hyperthermic-intraperitoneal-chemotherapy-hipec-safe-for-healthcare-workers
#11
REVIEW
Simon Rodier, Guillaume Saint-Lorant, Jean-Marc Guilloit, Agnès Palix, Fabienne Divanon, François Sichel, Raphaël Delépée
BACKGROUND: During hyperthermic intraperitoneal chemotherapy (HIPEC), caregivers are exposed by different routes to cytotoxic drugs. This review proposes an overview of the safety of HIPEC by assessing existing data on protection procedures, biological and non-biological samples. Based on these data, relevant good practices, eventual irrelevant overprotection procedures and missing data to implement adapted protections are highlighted. MATERIALS AND METHODS: Data were extracted from a systematic review of literature from 1980 till 2016: number and type of surgical procedure, healthcare professionals present, protective equipment, samples, pre-analytical method and analytical method...
September 2017: Surgical Oncology
https://www.readbyqxmd.com/read/28806406/terminal-differentiation-of-t-cells-is-strongly-associated-with-cmv-infection-and-increased-in-hiv-positive-individuals-on-art-and-lifestyle-matched-controls
#12
Thijs Booiman, Ferdinand W Wit, Arginell F Girigorie, Irma Maurer, Davide De Francesco, Caroline A Sabin, Agnes M Harskamp, Maria Prins, Claudio Franceschi, Steven G Deeks, Alan Winston, Peter Reiss, Neeltje A Kootstra
HIV-1-positive individuals on successful antiretroviral therapy (ART) are reported to have higher rates of age-associated non-communicable comorbidities (AANCCs). HIV-associated immune dysfunction has been suggested to contribute to increased AANCC risk. Here we performed a cross-sectional immune phenotype analysis of T cells in ART-treated HIV-1-positive individuals with undetectable vireamia (HIV-positives) and HIV-1-negative individuals (HIV-negatives) over 45 years of age. In addition, two control groups were studied: HIV negative adults selected based on lifestyle and demographic factors (Co-morBidity in Relation to AIDS, or COBRA) and unselected age-matched donors from a blood bank...
2017: PloS One
https://www.readbyqxmd.com/read/28806186/the-impact-of-cyp2c19-2-cyp4f2-3-and-clinical-factors-on-platelet-aggregation-cyp4f2-enzyme-activity-and-20-hydroxyeicosatetraenoic-acid-concentration-in-patients-treated-with-dual-antiplatelet-therapy
#13
Vacis Tatarunas, Nora Kupstyte, Agne Giedraitiene, Vilius Skipskis, Valdas Jakstas, Vaidotas Zvikas, Vaiva Lesauskaite
: The aim of the current study was to evaluate the impact of CYP2C192 (rs4244285), CYP4F23 (rs2108622), and nongenetic factors on platelet aggregation and to investigate the mechanism of CYP4F2's effect on platelet aggregation in the patients treated with dual antiplatelet therapy. A total of 146 patients were included in this study. Ticagrelor or clopidogrel were administered in a loading dose of 180 mg and 600 mg, respectively, in combination with aspirin (300 mg). Blood samples for analysis were taken the next morning after antiplatelet therapy induction...
August 12, 2017: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
https://www.readbyqxmd.com/read/28805170/perspectives-of-patients-close-relatives-nurses-and-physicians-on-end-of-life-medication-management
#14
Marianne K Dees, Eric C T Geijteman, Wim J M Dekkers, Bregje A A Huisman, Roberto S G M Perez, Lia van Zuylen, Agnes van der Heide, Evert van Leeuwen
OBJECTIVE: Our aim was to gain insight into the perspectives of patients, close relatives, nurses, and physicians on medication management for patients with a life expectancy of less than 3 months. METHOD: We conducted an empirical multicenter study with a qualitative approach, including in-depth interviews with patients, relatives, nurses, specialists, and general practitioners (GPs). We used the constant comparative method and ATLAS.ti (v. 7.1) software for our analysis...
August 14, 2017: Palliative & Supportive Care
https://www.readbyqxmd.com/read/28803719/assessment-of-aortic-valve-calcium-load-by-multidetector-computed-tomography-anatomical-validation-impact-of-scanner-settings-and-incremental-diagnostic-value
#15
Jamila Boulif, Bernhard Gerber, Alisson Slimani, Siham Lazam, Christophe de Meester, Sophie Piérard, Agnès Pasquet, Anne-Catherine Pouleur, David Vancraeynest, Gébrine El Khoury, Laurent de Kerchove, Philippe Noirhomme, Jean-Louis Vanoverschelde
OBJECTIVES: To validate aortic valve calcium (AVC) load measurements by multidetector row computed tomography (MDCT), to evaluate the impact of tube potential and slice thickness on AVC scores, to examine the accuracy of AVC load in distinguishing severe from nonsevere aortic stenosis (AS) and to investigate its effectiveness as an alternative diagnosis method when echocardiography remains inconclusive. METHODS: We prospectively studied 266 consecutive patients with moderate to severe AS who underwent MDCT to measure AVC load and a comprehensive echocardiographic examination to assess AS severity...
July 29, 2017: Journal of Cardiovascular Computed Tomography
https://www.readbyqxmd.com/read/28803147/ovarian-hormones-sleep-and-cognition-across-the-adult-female-lifespan-an-integrated-perspective
#16
REVIEW
Nicole J Gervais, Jessica A Mong, Agnès Lacreuse
Loss of ovarian function in women is associated with sleep disturbances and cognitive decline, which suggest a key role for estrogens and/or progestins in modulating these symptoms. The effects of ovarian hormones on sleep and cognitive processes have been studied in separate research fields that seldom intersect. However, sleep has a considerable impact on cognitive function. Given the tight connections between sleep and cognition, ovarian hormones may influence selective aspects of cognition indirectly, via the modulation of sleep...
August 9, 2017: Frontiers in Neuroendocrinology
https://www.readbyqxmd.com/read/28803090/palliative-care-in-rwanda-aiming-for-universal-access
#17
Eric L Krakauer, Marie-Aimee Muhimpundu, Diane Mukasahaha, Jean-Claude Tayari, Christian Ntizimira, Blaise Uhagaze, Théodosie Mugwaneza, Aimable Ruzima, Egide Mpanumusingo, Magnus Gasana, Vincent Karamuka, Jean-Luc Nkurikiyimfura, Paul Park, Peter Barebwanuwe, Neo Tapela, Shekinah N Elmore, Gene Bukhman, Mhoira Leng, Liz Grant, Agnes Binagwaho, Richard Sezibera
In 2011, Rwanda's Ministry of Health (MoH) set a goal of universal access to palliative care by 2020. Toward this audacious egalitarian and humanitarian goal, the MoH worked with partners to develop palliative care policies and a strategic plan, secure adequate supplies of opioid for the country, initiate palliative care training programs, and begin studying a model for integrating coordinated palliative care into the public healthcare system at all levels. It also initiated training of a new cadre of home-based care practitioners (HBCPs) to provide palliative care in the home...
August 9, 2017: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/28803074/hospice-palliative-care-development-in-hungary
#18
Agnes Csikos, Csilla Busa, Katalin Muszbek
During the past 25 years many developmental steps have occurred in Hungary in palliative care. Further education and service development is needed to provide a quality palliative care for all the Hungarian people. Hungary has a universal health care system with a developed infrastructure. The first Hungarian hospice team started in 1991. At that time the concept of hospice care was unknown. Symptom control and psychosocial support for the dying patient was inadequate. The regulatory framework was based on the 1997 Health Care Act which was followed by significant palliative care legislation including documents on the legal requirements for palliative care (2004)...
August 9, 2017: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/28802764/factors-influencing-renal-graft-survival-7-year-experience-of-a-single-center
#19
Rūta Auglienė, Eglė Dalinkevičienė, Vytautas Kuzminskis, Mindaugas Jievaltas, Laima Peleckaitė, Agnė Gryguc, Edgaras Stankevičius, Inga Arūnė Bumblytė
BACKGROUND AND OBJECTIVE: The demand for kidney transplants exceeds the existing supply. This leads to a recently growing interest of research in the area of factors that could prolong graft long-term outcomes and survival. In Lithuania, approximately 90% of kidney transplantations are from deceased donors. Donor organs are received and shared only inside the country territory in Lithuania; therefore, donor data is accurate and precise. This study was performed to present particularities of kidney transplantation data in Lithuania and to identify the effect of donor and recipient factors and histologic findings on renal graft outcomes...
July 29, 2017: Medicina
https://www.readbyqxmd.com/read/28801946/imitation-inhibition-in-children-with-tourette-syndrome
#20
Valerie Cathérine Brandt, Agnes Moczydlowski, Melanie Jonas, Kai Boelmans, Tobias Bäumer, Marcel Brass, Alexander Münchau
OBJECTIVE: Echopraxia, that is, the open and automatic imitation of other peoples' actions, is common in patients with Gilles de la Tourette syndrome, autism spectrum disorder, and also those with frontal lobe lesions. While systematic reaction time tasks have confirmed increased automatic imitation in the latter two groups, adult patients with Tourette syndrome appear to compensate for automatic imitation tendencies by an overall slowing in response times. However, whether children with Tourette syndrome are already able to inhibit automatic imitation tendencies has not been investigated...
August 12, 2017: Journal of Neuropsychology
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