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Acute heart failure review

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https://www.readbyqxmd.com/read/29158060/meta-analysis-of-the-outcome-after-postcardiotomy-venoarterial-extracorporeal-membrane-oxygenation-in-adult-patients
#1
Fausto Biancari, Andrea Perrotti, Magnus Dalén, Mariapia Guerrieri, Antonio Fiore, Daniel Reichart, Angelo M Dell'Aquila, Giuseppe Gatti, Tero Ala-Kokko, Eeva-Maija Kinnunen, Tuomas Tauriainen, Sidney Chocron, Juhani K E Airaksinen, Vito G Ruggieri, Debora Brascia
OBJECTIVE: This study was planned to pool existing data on outcome and to evaluate the efficacy of postcardiotomy venoarterial extracorporeal membrane oxygenation (VA-ECMO) in adult patients. DESIGN: Systematic review of the literature and meta-analysis. SETTING: Multi-institutional study. PARTICIPANTS: Adult patients with acute heart failure immediately after cardiac surgery. INTERVENTIONS: VA-ECMO after cardiac surgery...
September 1, 2017: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/29154687/pyruvate-enhancement-of-cardiac-performance-cellular-mechanisms-and-clinical-application
#2
Robert T Mallet, Albert H Olivencia-Yurvati, Rolf Bünger
Cardiac contractile function is adenosine-5'-triphosphate (ATP)-intensive, and the myocardium's high demand for oxygen and energy substrates leaves it acutely vulnerable to interruptions in its blood supply. The myriad cardioprotective properties of the natural intermediary metabolite pyruvate make it a potentially powerful intervention against the complex injury cascade ignited by myocardial ischemia-reperfusion. A readily oxidized metabolic substrate, pyruvate augments myocardial free energy of ATP hydrolysis to a greater extent than the physiological fuels glucose, lactate and fatty acids, particularly when it is provided at supra-physiological plasma concentrations...
January 1, 2017: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/29153201/troponin-in-heart-failure
#3
REVIEW
Kevin S Shah, Alan S Maisel, Gregg C Fonarow
Cardiac troponin is an integral biomarker in the evaluation and management of patients with acute coronary syndrome. Troponin is also established as a valuable prognostic marker in patients with acute or chronic heart failure (HF). As the sensitivity of troponin assays transition to high sensitive troponin, more patients with HF will have detectable troponin. In this review, the authors discuss the current literature on the value of troponin in the management of patients with HF. Furthermore, the authors highlight the potential for future strategies to use troponin as a potential target for therapy in patients with HF...
January 2018: Heart Failure Clinics
https://www.readbyqxmd.com/read/29153199/soluble-st2-in-heart-failure
#4
REVIEW
Cian P McCarthy, James L Januzzi
Suppression of tumorigenicity 2 (ST2) is a member of the interleukin (IL)-1 receptor family, whose role was originally established in the context of inflammatory and autoimmune diseases. More recently, testing for ST2 has been used in the setting of cardiovascular disease. The soluble form of ST2 is a decoy receptor that inhibits beneficial cardioprotective effects of IL-33; such inhibition results in cardiac hypertrophy, myocardial fibrosis, and ventricular dysfunction. Measurement of soluble ST2 has utility for assessing heart failure severity and prognosis...
January 2018: Heart Failure Clinics
https://www.readbyqxmd.com/read/29153195/proenkephalin-in-heart-failure
#5
REVIEW
Daniel Chu Siong Chan, Thong Huy Cao, Leong Loke Ng
The opioid system is activated in heart failure, which may be cardioprotective but may also be counter-regulatory. Recently, systemic proenkephalin activation has been investigated in various conditions predicting mortality and kidney injury. In acute heart failure, proenkephalin independently predicts mortality and heart failure rehospitalization in addition to traditional risk markers. It also predicts worsening renal function, increasingly recognized as an important risk predictor for poor outcome in heart failure...
January 2018: Heart Failure Clinics
https://www.readbyqxmd.com/read/29148856/novel-applications-for-serum-procalcitonin-testing-in-clinical-practice
#6
Justin J Choi, Matthew W McCarthy
Procalcitonin has emerged as a reliable marker of acute bacterial infection in hospitalized patients and the assay has recently been incorporated into several clinical algorithms to reduce antimicrobial overuse, but its use in patients with end-organ dysfunction is controversial. Areas covered: In this review, the authors examine what is known about procalcitonin testing in patients with organ dysfunction, including those with end-stage renal disease, congestive heart failure, chronic obstructive pulmonary disease, and cirrhosis, and explore how the assay is now being used in the management of non-infectious diseases...
November 17, 2017: Expert Review of Molecular Diagnostics
https://www.readbyqxmd.com/read/29146419/syncope-on-presentation-is-a-surrogate-for-submassive-and-massive-acute-pulmonary-embolism
#7
Hesham R Omar, Mehdi Mirsaeidi, Michael B Weinstock, Garett Enten, Devanand Mangar, Enrico M Camporesi
INTRODUCTION: There are conflicting data regarding the prognostic value of syncope in patients with acute pulmonary embolism (APE). METHODS: We retrospectively reviewed data of 552 consecutive adults with computed tomography pulmonary angiogram-confirmed APE to determine the correlates and outcome of the occurrence of syncope at the time of presentation. RESULTS: Among 552 subjects with APE (mean age 54years, 47% men), syncope occurred in 12...
November 7, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29145282/autosomal-dominant-polycystic-kidney-disease-combined-with-hypertrophic-cardiomyopathy-a-case-report
#8
Yingjing Shen, Chenggang Xu
INTRODUCTION: This report describes the novel sampling of autosomal dominant polycystic kidney disease (ADPKD) combined with hypertrophic cardiomyopathy (HCM). SYMPTOMS AND CLINICAL FINDINGS: A 48-year-old Chinese man presented with anasarca, hypourocrinia, gross hematuria, and weight gain by 10 kg subsequently developed acute kidney injury after struck by acute respiratory distress syndrome, really a threat to his heart. DIAGNOSES: Abdominal ultrasound revealed multiple small cysts in both kidneys, with the right kidney measuring 11...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29143812/the-nlrp3-inflammasome-in-acute-myocardial-infarction
#9
REVIEW
Stefano Toldo, Antonio Abbate
The heart is extremely sensitive to ischaemic injury. During an acute myocardial infarction (AMI) event, the injury is initially caused by reduced blood supply to the tissues, which is then further exacerbated by an intense and highly specific inflammatory response that occurs during reperfusion. Numerous studies have highlighted the central role of the NACHT, LRR, and PYD domains-containing protein 3 (NLRP3) inflammasome in this process. The inflammasome, an integral part of the innate immune system, is a macromolecular protein complex that finely regulates the activation of caspase 1 and the production and secretion of powerful pro-inflammatory cytokines such as IL-1β and IL-18...
November 16, 2017: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/29141552/para-prosthetic-leaks-following-mitral-valve-replacement-case-analysis-on-a-20-year-period
#10
Melvin Dziubek, Charalampos Pierrakos, Louis Chebli, Helene Demanet, Ahmed Sanoussi, Pierre Wauthy
BACKGROUND: Mitral para-prosthetic leaks are rare but major complications of mitral heart valve replacements. When they must be re-operated, they are burdened with high mortality rates. We propose to review our surgical experience in terms of approach and type of operation carried out. METHODS: Demographic, preoperative, intraoperative and postoperative characteristics of 34 patients who benefited from a surgical treatment of mitral paravalvular leak at the Brugmann University Hospital between 1996 and 2016 have been gathered retrospectively...
November 9, 2017: Current Cardiology Reviews
https://www.readbyqxmd.com/read/29124524/high-comorbidity-measured-by-the-charlson-comorbidity-index-associates-with-higher-1-year-mortality-risks-in-elderly-patients-experiencing-a-first-acute-heart-failure-hospitalization
#11
Francesc Formiga, Rafael Moreno-Gonzalez, David Chivite, Jonathan Franco, Abelardo Montero, Xavier Corbella
BACKGROUND: Comorbidity is related to poor health results in chronic heart failure (HF). AIMS: The purpose of the study was to assess whether a high Charlson Comorbidity Index score (CCI) relates to 1 year mortality after a first hospitalization for acute HF (AHF). METHODS: We reviewed the medical records of 897 patients > 65 years of age admitted within a two-year period because of a first episode of AHF. We analyzed two groups: low (CCI ≤ 2) and high (CCI > 2) comorbidity...
November 9, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/29122235/-acute-stress-and-broken-heart-syndrome-a-case-report
#12
Juliana Vergel, Sebastián Tamayo-Orozco, Andrés Felipe Vallejo-Gómez, María Teresa Posada, Diana Restrepo
INTRODUCTION: Stress has been associated with an acute heart failure syndrome of important morbidity and mortality. METHODS: Case report and non-systematic review of the relevant literature. CASE PRESENTATION: A 65-year-old woman with a history of an untreated generalized anxiety disorder, whom after the violent death of her son presented with oppressive chest pain irradiated to neck and left superior extremity, lasting for more than 30minutes, initial clinical suspect suggests acute coronary syndrome...
October 2017: Revista Colombiana de Psiquiatría
https://www.readbyqxmd.com/read/29121725/real-world-study-of-low-density-lipoprotein-cholesterol-levels-and-cardiovascular-outcomes-in-chinese-a-retrospective-cohort-study-in-post-percutaneous-coronary-intervention-acute-coronary-syndrome-patients
#13
Yun Wang, Bryan P Yan, Michael B Nichol, Brian Tomlinson, Vivian W Y Lee
BACKGROUND: This study aimed to assess the effect of low-density lipoprotein cholesterol (LDL-C) goal attainments (of <2.6mmol/L and <1.8mmol/L) on first major adverse cardiovascular events (MACEs) for acute coronary syndrome (ACS) patients who underwent percutaneous coronary intervention (PCI). METHODS: A retrospective cohort study was conducted using case reviews of post-PCI ACS patients at an acute public hospital in Hong Kong between January 2009 and August 2015...
December 15, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/29121720/incidence-predictors-and-outcomes-of-infective-endocarditis-in-a-contemporary-adult-congenital-heart-disease-population
#14
Benjamin Moore, Jacob Cao, Irina Kotchetkova, David S Celermajer
BACKGROUND: The prevalence of congenital heart disease (CHD) in the adult population is steadily increasing. A substrate of prosthetic material and residual lesions, constantly evolving as surgical techniques change over time, predispose these patients to the potentially devastating complication of infective endocarditis (IE). METHODS: We retrospectively reviewed 2935 patients in our adult CHD database for all cases of endocarditis between 1991 and 2016. Incidence, clinical course and predictors of outcomes were analysed...
December 15, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/29111107/mind-the-gap-current-challenges-and-future-state-of-heart-failure-care
#15
REVIEW
Michael A McDonald, Euan A Ashley, Paul W M Fedak, Nathaniel Hawkins, James L Januzzi, John J V McMurray, Victoria N Parikh, Vivek Rao, Daniyil Svystonyuk, John R Teerlink, Sean Virani
The past decade has seen many advances in the management of heart failure (HF) that have improved survival and quality of life for patients living with this condition. A number of gaps remain in our understanding of the pathophysiology of HF, and the application of emerging treatment strategies is an exciting but daunting challenge. It is possible that advances in genetic evaluation of cardiomyopathy will provide a more refined approach to characterizing HF syndromes, whereas large-scale clinical trials on the horizon should further clarify the role of novel pharmacologic agents and invasive therapies...
November 2017: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/29101147/protocol-for-the-happy-hearts-study-cardiovascular-screening-for-the-early-detection-of-future-adverse-cardiovascular-outcomes-in-middle-aged-and-older-women-a-prospective-observational-cohort-study
#16
Kevin F Boreskie, D Scott Kehler, Eduardo C Costa, Pedro C Cortez, Ivan Berkowitz, Naomi C Hamm, Teri L Moffatt, Andrew N Stammers, Dustin E Kimber, Brett M Hiebert, David E Kent, Denise E Cornish, Heather Blewett, Thang Nguyen, Rakesh C Arora, Shaelyn M Strachan, Brittany N Semenchuk, Jacqueline L Hay, Jay N Cohn, Todd A Duhamel
INTRODUCTION: Efforts to identify individuals at a higher risk for adverse cardiovascular outcomes focus on traditional risk factors, such as age, sex, smoking status, blood pressure and and cholesterol; however, this approach does not directly assess cardiovascular function and may underestimate the risk of experiencing adverse cardiovascular outcomes in women. This prospective, observational cohort study will examine the ability of the Heart Attack Prevention Program for You (HAPPY) Hearts screening protocol, a series of non-invasive procedures to identify middle-aged and older women who are at an elevated risk for experiencing an adverse cardiovascular event in the 5-year period after screening...
November 3, 2017: BMJ Open
https://www.readbyqxmd.com/read/29100896/liver-disease-and-heart-failure-back-and-forth
#17
REVIEW
Michele Correale, Nicola Tarantino, Rossella Petrucci, Lucia Tricarico, Irma Laonigro, Matteo Di Biase, Natale Daniele Brunetti
In their clinical practice, physicians can face heart diseases (chronic or acute heart failure) affecting the liver and liver diseases affecting the heart. Systemic diseases can also affect both heart and liver. Therefore, it is crucial in clinical practice to identify complex interactions between heart and liver, in order to provide the best treatment for both. In this review, we sought to summarize principal evidence explaining the mechanisms and supporting the existence of this complicate cross-talk between heart and liver...
October 31, 2017: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/29098626/micrornas-mediate-beneficial-effects-of-exercise-in-heart
#18
Yihua Bei, Lichan Tao, Dragos Cretoiu, Sanda Maria Cretoiu, Junjie Xiao
MicroRNAs (miRNAs, miRs), a group of small non-coding RNAs, repress gene expressions at posttranscriptional level in most cases and are involved in cardiovascular physiology and disease pathogenesis. Increasing evidence has proved that miRNAs are potential regulators of exercise induced cardiac growth and mediate the benefits of exercise in a variety of cardiovascular diseases. In this chapter, we will review the regulatory effects of miRNAs in cardiac adaptations to exercise, and summarize their cardioprotective effects against myocardial infarction, ischemia/reperfusion injury, heart failure, diabetic cardiomyopathy, atherosclerosis, hypertension, and pulmonary hypertension...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29082676/lessons-learned-in-acute-heart-failure
#19
REVIEW
Baljash Cheema, Andrew P Ambrosy, Rachel M Kaplan, Michele Senni, Gregg C Fonarow, Ovidiu Chioncel, Javed Butler, Mihai Gheorghiade
Acute heart failure (HF) is a global pandemic with more than one million admissions to hospital annually in the US and millions more worldwide. Post-discharge mortality and readmission rates remain unchanged and unacceptably high. Although recent drug development programmes have failed to deliver novel therapies capable of reducing cardiovascular morbidity and mortality in patients hospitalized for worsening chronic HF, hospitalized HF registries and clinical trial databases have generated a wealth of information improving our collective understanding of the HF syndrome...
October 29, 2017: European Journal of Heart Failure
https://www.readbyqxmd.com/read/29072885/cardiopulmonary-ultrasound-for-critically-ill-adults-improves-diagnostic-accuracy-in-a-resource-limited-setting-the-africa-trial
#20
Torben K Becker, Chelsea A Tafoya, Maxwell Osei-Ampofo, Matthew J Tafoya, Ross A Kessler, Nikhil Theyyunni, Hussein A Yakubu, Daniel Opuni, Daniel J Clauw, James A Cranford, Chris K Oppong, Rockefeller A Oteng
OBJECTIVE: To assess the effects of a cardiopulmonary ultrasound (CPUS) examination on diagnostic accuracy for critically ill patients in a resource-limited setting. METHODS: Approximately half of the emergency medicine resident physicians at the Komfo Anokye Teaching Hospital (KATH) in Kumasi, Ghana, were trained in a CPUS protocol. Adult patients triaged to the resuscitation area of the emergency department (ED) were enrolled if they exhibited signs or symptoms of shock or respiratory distress...
October 26, 2017: Tropical Medicine & International Health: TM & IH
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