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https://www.readbyqxmd.com/read/28817967/pimavanserin-a-novel-antipsychotic-for-management-of-parkinson-s-disease-psychosis
#1
REVIEW
Yasaman Kianirad, Tanya Simuni
Parkinson's disease psychosis (PDP) may develop in up to 60% of Parkinson's patients and is associated with increased morbidity and mortality. It also correlates with depression and dementia, and can contribute to caregiver stress and burnout. Pimavanserin is the first FDA approved drug for the treatment of hallucinations and delusions associated with PDP. Areas covered: For this review, a MEDLINE literature search (via PubMed) and information provided by ACADIA Pharmaceuticals were used. This review will discuss the pathophysiology and current management of PDP...
November 2017: Expert Review of Clinical Pharmacology
https://www.readbyqxmd.com/read/28792100/understanding-sources-of-methylmercury-in-songbirds-with-stable-mercury-isotopes-challenges-and-future-directions
#2
Martin Tsz-Ki Tsui, Evan M Adams, Allyson K Jackson, David C Evers, Joel D Blum, Steven J Balogh
Mercury (Hg) stable isotope analysis is an emerging technique that has contributed to a better understanding of many aspects of the biogeochemical cycling of Hg in the environment. However, no study has yet evaluated its usefulness in elucidating the sources of methylmercury (MeHg) in songbird species, a common organism for biomonitoring of Hg in forested ecosystems. In the present pilot study, we examined stable mercury isotope ratios in blood of 4 species of songbirds and the invertebrates they are likely foraging on in multiple habitats in a small watershed of mixed forest and wetlands in Acadia National Park in Maine (USA)...
August 9, 2017: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/28636480/the-emerging-role-of-pimavanserin-in-the-management-of-parkinson-s-disease-psychosis
#3
Neal Hermanowicz, Gustavo Alva, Fernando Pagan, Alberto J Espay, Amita Patel, Katya Cruz Madrid, Daniel Kremens, Jim Kenney, Sheila Arquette, Gary Tereso, Maria Lopes, Carolyn Farnum
A panel of experts drawn from neurology, psychiatry, geropsychiatry, geriatrics, and pharmacy representatives of 3 health plans convened in New York City on July 30, 2016, with the objective of sharing opinions, ideas, and information regarding the optimal management of Parkinson's disease psychosis (PDP). Three key points emerged from the discussion: (1) Because of the nature of Parkinson's disease and PDP, finding appropriate treatment can prove challenging; (2) emerging therapies may present an opportunity for effective disease management; and (3) moving forward, provider and patient education regarding PDP and available treatment options is essential for well-managed symptoms and better quality of life...
June 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28609939/additions-to-the-hydroids-cnidaria-hydrozoa-of-the-bay-of-fundy-northeastern-north-america-with-a-checklist-of-species-reported-from-the-region
#4
Dale R Calder
Two new species of hydroids, Eudendrium bleakneyi and Halecium praeparvum, are described from the Bay of Fundy. Fourteen others, Tubularia acadiae Petersen, 1990, Coryne pusilla Gaertner, 1774, Sarsia lovenii (M. Sars, 1846), Zanclea implexa (Alder, 1856), Corydendrium dispar Kramp, 1935, Rhizogeton fusiformis L. Agassiz, 1862, Bougainvillia muscus (Allman, 1863), Rhizorhagium roseum M. Sars, in G.O. Sars, 1874, Hydractinia symbiolongicarpus Buss & Yund, 1989, Eudendrium vaginatum Allman, 1863, Tiaropsis multicirrata (M...
April 24, 2017: Zootaxa
https://www.readbyqxmd.com/read/28333766/dietary-inadequacies-in-hiv-infected-and-uninfected-school-aged-children-in-johannesburg-south-africa
#5
Stephanie Shiau, Acadia Webber, Renate Strehlau, Faeezah Patel, Ashraf Coovadia, Samantha Kozakowski, Susan Brodlie, Michael T Yin, Louise Kuhn, Stephen M Arpadi
OBJECTIVES: The World Health Organization recommends that human immunodeficiency virus (HIV)-infected children increase energy intake and maintain a balanced macronutrient distribution for optimal growth and nutrition. Few studies have evaluated dietary intake of HIV-infected children in resource-limited settings. METHODS: We conducted a cross-sectional analysis of the dietary intake of 220 perinatally HIV-infected children and 220 HIV-uninfected controls ages 5 to 9 years in Johannesburg, South Africa...
September 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28025922/comprehensive-medication-reviews-in-long-term-care-facilities-history-of-process-implementation-and-2015-results
#6
Terrence E O'Shea, Barbara J Zarowitz, W Gary Erwin
BACKGROUND: Since 2013, Part D sponsors have been required to offer comprehensive medication reviews (CMRs) to all beneficiaries enrolled in their medication therapy management (MTM) programs at least annually, including those in long-term care (LTC) settings. Since that time, MTM providers have found that accessing and completing CMRs with beneficiaries is frequently prohibitively complex, since the process often requires a live, face-to-face interactive interview where the beneficiary resides...
January 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/27761878/moderate-endoplasmic-reticulum-stress-activates-a-perk-and-p38-dependent-apoptosis
#7
Emily C Lumley, Acadia R Osborn, Jessica E Scott, Amanda G Scholl, Vicki Mercado, Young T McMahan, Zachary G Coffman, Jay L Brewster
The endoplasmic reticulum (ER) has the ability to signal organelle dysfunction via a complex signaling network known as the unfolded protein response (UPR). In this work, hamster fibroblast cells exhibiting moderate levels of ER stress were compared to those exhibiting severe ER stress. Inhibition of N-linked glycosylation was accomplished via a temperature-sensitive mutation in the Dad1 subunit of the oligosaccharyltransferase (OST) complex or by direct inhibition with tunicamycin (Tm). Temperature shift (TS) treatment generated weak activation of ER stress signaling when compared to doses of Tm that are typically used in ER stress studies (500-1000 nM)...
January 2017: Cell Stress & Chaperones
https://www.readbyqxmd.com/read/27703782/ketamine-stimulating-antidepressant-treatment
#8
EDITORIAL
Gin S Malhi, Yulisha Byrow, Frederick Cassidy, Andrea Cipriani, Koen Demyttenaere, Mark A Frye, Michael Gitlin, Sidney H Kennedy, Terence A Ketter, Raymond W Lam, Rupert McShane, Alex J Mitchell, Michael J Ostacher, Sakina J Rizvi, Michael E Thase, Mauricio Tohen
SUMMARY: The appeal of ketamine - in promptly ameliorating depressive symptoms even in those with non-response - has led to a dramatic increase in its off-label use. Initial promising results await robust corroboration and key questions remain, particularly concerning its long-term administration. It is, therefore, timely to review the opinions of mood disorder experts worldwide pertaining to ketamine's potential as an option for treating depression and provide a synthesis of perspectives - derived from evidence and clinical experience - and to consider strategies for future investigations...
May 2016: BJPsych Open
https://www.readbyqxmd.com/read/27609312/pimavanserin-for-the-treatment-of-parkinson-s-disease-psychosis
#9
REVIEW
Ines Chendo, Joaquim J Ferreira
INTRODUCTION: Parkinson´s disease (PD) is a synucleinopathy that affects millions of people worldwide and leads to progressive disability. Psychosis is highly prevalent in PD patients and is associated with poor prognosis. Until April 2016, there were no licensed drugs available in the United States of America (USA) for the treatment of PD psychosis (PDP). Pimavanserin is the first Food and Drug Administration approved medicine for the treatment of hallucinations and delusions associated with PDP...
October 2016: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/27361847/the-effect-of-performance-enhancing-clothing-on-dynamic-balance-a-randomized-double-blind-study-3278-board-343-june-3-3-30-pm-5-00-pm
#10
Anna M McGarr, Christopher Villarosa, Toshiki Kobayashi, Laura J Davis, Acadia L Clohesey, Michelle E Judge, Miran D McCash, Juhanna T Roberts, Claudia Espina Bresnahan, Michael S Orendurff
No abstract text is available yet for this article.
May 2016: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/27361844/the-effect-of-technology-enhanced-clothing-on-low-back-and-hamstring-flexibility-3275-board-340-june-3-3-30-pm-5-00-pm
#11
Acadia L Clohesey, Michelle E Judge, Miran D McCash, Juhanna T Roberts, Claudia Espina Bresnahan, Anna M McGarr, Christopher Villarosa, Toshiki Kobayashi, Laura J Davis, Michael S Orendurff
No abstract text is available yet for this article.
May 2016: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/27361843/the-effect-of-microclimate-enhanced-clothing-on-grip-strength-a-randomized-double-blind-study-3274-board-339-june-3-3-30-pm-5-00-pm
#12
Miran D McCash, Juhanna T Roberts, Claudia Espina Bresnahan, Anna M McGarr, Christopher Villarosa, Toshiki Kobayashi, Laura J Davis, Acadia L Clohesey, Michelle E Judge, Michael S Orendurff
No abstract text is available yet for this article.
May 2016: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/27360512/unique-balance-domains-for-balance-error-scoring-system-bess-and-y-balance-tests-1593-board-246-june-2-9-00-am-10-30-am
#13
Laura J Davis, Anna M McGarr, Claudia Espina Bresnahan, Acadia L Clohesey, Michelle E Judge, Miran D McCash, Juhanna T Roberts, Christopher Villarosa, Toshiki Kobayashi, Michael S Orendurff
No abstract text is available yet for this article.
May 2016: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/27360167/effects-of-performance-enhancing-clothing-on-cardiovascular-endurance-a-randomized-double-blind-study-with-deception-1024-board-340-june-1-2-00-pm-3-30-pm
#14
Michelle E Judge, Anna M McGarr, Christopher Villarosa, Toshiki Kobayashi, Laura J Davis, Acadia L Clohesey, Miran D McCash, Juhanna T Roberts, Claudia Espina Bresnahan, Michael S Orendurff
No abstract text is available yet for this article.
May 2016: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/27360117/a-randomized-double-blind-protocol-with-deception-to-evaluate-claims-of-balance-improvement-by-enhanced-clothing-974-board-290-june-1-3-30-pm-5-00-pm
#15
Claudia Espina Bresnahan, Anna M McGarr, Christopher Villarosa, Toshiki Kobayashi, Laura J Davis, Acadia L Clohesey, Michelle E Judge, Miran D McCash, Juhanna T Roberts, Michael S Orendurff
No abstract text is available yet for this article.
May 2016: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/27262680/pimavanserin-first-global-approval
#16
REVIEW
Anthony Markham
Pimavanserin (Nuplazid™) is a selective and potent serotonin 2A (5-HT2A) receptor inverse agonist and antagonist developed by ACADIA Pharmaceuticals that has been approved in the US as a treatment for patients with hallucinations and delusions associated with Parkinson's disease psychosis. Up to 60 % of patients with Parkinson's disease may develop Parkinson's disease psychosis, which is associated with increased morbidity and mortality and has few treatment options. This article summarizes the milestones in the development of pimavanserin leading to this first approval for the treatment of hallucinations and delusions in patients with Parkinson's disease psychosis...
July 2016: Drugs
https://www.readbyqxmd.com/read/26656127/postglacial-migration-and-adaptation-for-dispersal-in-pitch-pine-pinaceae
#17
F Thomas Ledig, Peter E Smouse, John L Hom
PREMISE OF THE STUDY: Variation in a species is a blend of adaptive, random, and migratory responses. Pitch pine (Pinus rigida), a highly variable eastern conifer, has occupied multiple glacial refugia, whose harsh conditions favored adaptations enhancing subsequent dispersal and recolonization of newly deglaciated sites. We assessed phenotypic diversity in long-term growth trials to elucidate both the adaptations and likely refugia. METHODS: Pitch pine progeny from 31 areas were grown in common gardens in six locations, from eastern Massachusetts to Korea...
December 2015: American Journal of Botany
https://www.readbyqxmd.com/read/26313982/expansion-of-the-mexican-rice-borer-lepidoptera-crambidae-into-rice-and-sugarcane-in-louisiana
#18
B E Wilson, T N Hardy, J M Beuzelin, M T VanWeelden, T E Reagan, R Miller, J Meaux, M J Stout, C E Carlton
The Mexican rice borer, Eoreuma loftini (Dyar) (Lepidoptera: Crambidae), is an invasive pest of sugarcane, Saccharum spp., rice, Oryza sativa L., and other graminaceous crops in the Gulf Coast region of the United States. Traps baited with E. loftini female sex pheromones were used to document establishment and distribution of E. loftini near sugarcane, rice, and noncrop hosts in seven southwest Louisiana parishes from 2009 to 2013. Additional field surveys documented larval infestations in commercial sugarcane and rice...
June 2015: Environmental Entomology
https://www.readbyqxmd.com/read/26225933/the-effect-of-minimum-impact-education-on-visitor-spatial-behavior-in-parks-and-protected-areas-an-experimental-investigation-using-gps-based-tracking
#19
Abigail M Kidd, Christopher Monz, Ashley D'Antonio, Robert E Manning, Nathan Reigner, Kelly A Goonan, Charles Jacobi
The unmanaged impacts of recreation and tourism can often result in unacceptable changes in resource conditions and quality of the visitor experience. Minimum impact visitor education programs aim to reduce the impacts of recreation by altering visitor behaviors. Specifically, education seeks to reduce impacts resulting from lack of knowledge both about the consequences of one's actions and impact-minimizing best practices. In this study, three different on-site minimum impact education strategies ("treatments") and a control condition were applied on the trails and summit area of Sargent Mountain in Acadia National Park, Maine...
October 1, 2015: Journal of Environmental Management
https://www.readbyqxmd.com/read/25947121/evaluation-of-assumptions-for-estimating-chemical-light-extinction-at-u-s-national-parks
#20
Douglas Lowenthal, Barbara Zielinska, Vera Samburova, Don Collins, Nathan Taylor, Naresh Kumar
UNLABELLED: Studies were conducted at Great Smoky Mountains National Park (NP) (GRSM), Tennessee, Mount Rainier NP (MORA), Washington, and Acadia NP (ACAD), Maine, to evaluate assumptions used to estimate aerosol light extinction from chemical composition. The revised IMPROVE equation calculates light scattering from concentrations of PM2.5 sulfates, nitrates, organic carbon mass (OM), and soil. Organics are assumed to be nonhygroscopic. Organic carbon (OC) is converted to OM with a multiplier of 1...
March 2015: Journal of the Air & Waste Management Association
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