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https://www.readbyqxmd.com/read/27761878/moderate-endoplasmic-reticulum-stress-activates-a-perk-and-p38-dependent-apoptosis
#1
Emily C Lumley, Acadia R Osborn, Jessica E Scott, Amanda G Scholl, Vicki Mercado, Young T McMahan, Zachary G Coffman, Jay L Brewster
The endoplasmic reticulum (ER) has the ability to signal organelle dysfunction via a complex signaling network known as the unfolded protein response (UPR). In this work, hamster fibroblast cells exhibiting moderate levels of ER stress were compared to those exhibiting severe ER stress. Inhibition of N-linked glycosylation was accomplished via a temperature-sensitive mutation in the Dad1 subunit of the oligosaccharyltransferase (OST) complex or by direct inhibition with tunicamycin (Tm). Temperature shift (TS) treatment generated weak activation of ER stress signaling when compared to doses of Tm that are typically used in ER stress studies (500-1000 nM)...
October 20, 2016: Cell Stress & Chaperones
https://www.readbyqxmd.com/read/27703782/ketamine-stimulating-antidepressant-treatment
#2
Gin S Malhi, Yulisha Byrow, Frederick Cassidy, Andrea Cipriani, Koen Demyttenaere, Mark A Frye, Michael Gitlin, Sidney H Kennedy, Terence A Ketter, Raymond W Lam, Rupert McShane, Alex J Mitchell, Michael J Ostacher, Sakina J Rizvi, Michael E Thase, Mauricio Tohen
SUMMARY: The appeal of ketamine - in promptly ameliorating depressive symptoms even in those with non-response - has led to a dramatic increase in its off-label use. Initial promising results await robust corroboration and key questions remain, particularly concerning its long-term administration. It is, therefore, timely to review the opinions of mood disorder experts worldwide pertaining to ketamine's potential as an option for treating depression and provide a synthesis of perspectives - derived from evidence and clinical experience - and to consider strategies for future investigations...
May 2016: BJPsych Open
https://www.readbyqxmd.com/read/27609312/pimavanserin-for-the-treatment-of-parkinson-s-disease-psychosis
#3
Ines Chendo, Joaquim J Ferreira
INTRODUCTION: Parkinson´s disease (PD) is a synucleinopathy that affects millions of people worldwide and leads to progressive disability. Psychosis is highly prevalent in PD patients and is associated with poor prognosis. Until April 2016, there were no licensed drugs available in the United States of America (USA) for the treatment of PD psychosis (PDP). Pimavanserin is the first Food and Drug Administration approved medicine for the treatment of hallucinations and delusions associated with PDP...
October 2016: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/27361847/the-effect-of-performance-enhancing-clothing-on-dynamic-balance-a-randomized-double-blind-study-3278-board-343-june-3-3-30-pm-5-00-pm
#4
Anna M McGarr, Christopher Villarosa, Toshiki Kobayashi, Laura J Davis, Acadia L Clohesey, Michelle E Judge, Miran D McCash, Juhanna T Roberts, Claudia Espina Bresnahan, Michael S Orendurff
No abstract text is available yet for this article.
May 2016: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/27361844/the-effect-of-technology-enhanced-clothing-on-low-back-and-hamstring-flexibility-3275-board-340-june-3-3-30-pm-5-00-pm
#5
Acadia L Clohesey, Michelle E Judge, Miran D McCash, Juhanna T Roberts, Claudia Espina Bresnahan, Anna M McGarr, Christopher Villarosa, Toshiki Kobayashi, Laura J Davis, Michael S Orendurff
No abstract text is available yet for this article.
May 2016: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/27361843/the-effect-of-microclimate-enhanced-clothing-on-grip-strength-a-randomized-double-blind-study-3274-board-339-june-3-3-30-pm-5-00-pm
#6
Miran D McCash, Juhanna T Roberts, Claudia Espina Bresnahan, Anna M McGarr, Christopher Villarosa, Toshiki Kobayashi, Laura J Davis, Acadia L Clohesey, Michelle E Judge, Michael S Orendurff
No abstract text is available yet for this article.
May 2016: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/27360512/unique-balance-domains-for-balance-error-scoring-system-bess-and-y-balance-tests-1593-board-246-june-2-9-00-am-10-30-am
#7
Laura J Davis, Anna M McGarr, Claudia Espina Bresnahan, Acadia L Clohesey, Michelle E Judge, Miran D McCash, Juhanna T Roberts, Christopher Villarosa, Toshiki Kobayashi, Michael S Orendurff
No abstract text is available yet for this article.
May 2016: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/27360167/effects-of-performance-enhancing-clothing-on-cardiovascular-endurance-a-randomized-double-blind-study-with-deception-1024-board-340-june-1-2-00-pm-3-30-pm
#8
Michelle E Judge, Anna M McGarr, Christopher Villarosa, Toshiki Kobayashi, Laura J Davis, Acadia L Clohesey, Miran D McCash, Juhanna T Roberts, Claudia Espina Bresnahan, Michael S Orendurff
No abstract text is available yet for this article.
May 2016: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/27360117/a-randomized-double-blind-protocol-with-deception-to-evaluate-claims-of-balance-improvement-by-enhanced-clothing-974-board-290-june-1-3-30-pm-5-00-pm
#9
Claudia Espina Bresnahan, Anna M McGarr, Christopher Villarosa, Toshiki Kobayashi, Laura J Davis, Acadia L Clohesey, Michelle E Judge, Miran D McCash, Juhanna T Roberts, Michael S Orendurff
No abstract text is available yet for this article.
May 2016: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/27262680/pimavanserin-first-global-approval
#10
Anthony Markham
Pimavanserin (Nuplazid™) is a selective and potent serotonin 2A (5-HT2A) receptor inverse agonist and antagonist developed by ACADIA Pharmaceuticals that has been approved in the US as a treatment for patients with hallucinations and delusions associated with Parkinson's disease psychosis. Up to 60 % of patients with Parkinson's disease may develop Parkinson's disease psychosis, which is associated with increased morbidity and mortality and has few treatment options. This article summarizes the milestones in the development of pimavanserin leading to this first approval for the treatment of hallucinations and delusions in patients with Parkinson's disease psychosis...
July 2016: Drugs
https://www.readbyqxmd.com/read/26656127/postglacial-migration-and-adaptation-for-dispersal-in-pitch-pine-pinaceae
#11
F Thomas Ledig, Peter E Smouse, John L Hom
PREMISE OF THE STUDY: Variation in a species is a blend of adaptive, random, and migratory responses. Pitch pine (Pinus rigida), a highly variable eastern conifer, has occupied multiple glacial refugia, whose harsh conditions favored adaptations enhancing subsequent dispersal and recolonization of newly deglaciated sites. We assessed phenotypic diversity in long-term growth trials to elucidate both the adaptations and likely refugia. METHODS: Pitch pine progeny from 31 areas were grown in common gardens in six locations, from eastern Massachusetts to Korea...
December 2015: American Journal of Botany
https://www.readbyqxmd.com/read/26313982/expansion-of-the-mexican-rice-borer-lepidoptera-crambidae-into-rice-and-sugarcane-in-louisiana
#12
B E Wilson, T N Hardy, J M Beuzelin, M T VanWeelden, T E Reagan, R Miller, J Meaux, M J Stout, C E Carlton
The Mexican rice borer, Eoreuma loftini (Dyar) (Lepidoptera: Crambidae), is an invasive pest of sugarcane, Saccharum spp., rice, Oryza sativa L., and other graminaceous crops in the Gulf Coast region of the United States. Traps baited with E. loftini female sex pheromones were used to document establishment and distribution of E. loftini near sugarcane, rice, and noncrop hosts in seven southwest Louisiana parishes from 2009 to 2013. Additional field surveys documented larval infestations in commercial sugarcane and rice...
June 2015: Environmental Entomology
https://www.readbyqxmd.com/read/26225933/the-effect-of-minimum-impact-education-on-visitor-spatial-behavior-in-parks-and-protected-areas-an-experimental-investigation-using-gps-based-tracking
#13
Abigail M Kidd, Christopher Monz, Ashley D'Antonio, Robert E Manning, Nathan Reigner, Kelly A Goonan, Charles Jacobi
The unmanaged impacts of recreation and tourism can often result in unacceptable changes in resource conditions and quality of the visitor experience. Minimum impact visitor education programs aim to reduce the impacts of recreation by altering visitor behaviors. Specifically, education seeks to reduce impacts resulting from lack of knowledge both about the consequences of one's actions and impact-minimizing best practices. In this study, three different on-site minimum impact education strategies ("treatments") and a control condition were applied on the trails and summit area of Sargent Mountain in Acadia National Park, Maine...
October 1, 2015: Journal of Environmental Management
https://www.readbyqxmd.com/read/25947121/evaluation-of-assumptions-for-estimating-chemical-light-extinction-at-u-s-national-parks
#14
Douglas Lowenthal, Barbara Zielinska, Vera Samburova, Don Collins, Nathan Taylor, Naresh Kumar
UNLABELLED: Studies were conducted at Great Smoky Mountains National Park (NP) (GRSM), Tennessee, Mount Rainier NP (MORA), Washington, and Acadia NP (ACAD), Maine, to evaluate assumptions used to estimate aerosol light extinction from chemical composition. The revised IMPROVE equation calculates light scattering from concentrations of PM2.5 sulfates, nitrates, organic carbon mass (OM), and soil. Organics are assumed to be nonhygroscopic. Organic carbon (OC) is converted to OM with a multiplier of 1...
March 2015: Journal of the Air & Waste Management Association
https://www.readbyqxmd.com/read/25748367/c-t-jackson-s-sealed-13-november-1846-letter-to-j-b-a-l-l-%C3%A3-lie-de-beaumont-translated-1847-back-translated-1861-and-accurately-transcribed-for-the-first-time-2014
#15
George S Bause
Besides the famous London-bound Bigelow-to-Boot letter dated November 28, 1846, the mail bags of the steam paddler Acadia also carried, from Boston to Liverpool, additional correspondence reporting W.T.G. Morton's public demonstration of surgical etherization. Paramount among these other letters was the wax-sealed English language missive of Charles T. Jackson to the French Academy of Science's J.B.A.L.L. Élie de Beaumont, which was dated November 13, 1846. Unfortunately, Jackson made no copy of this original letter...
January 2015: Journal of Anesthesia History
https://www.readbyqxmd.com/read/25561715/tfox-based-genetic-mapping-identifies-vibrio-fischeri-strain-level-differences-and-reveals-a-common-lineage-of-laboratory-strains
#16
John F Brooks, Mattias C Gyllborg, Acadia A Kocher, Laura E H Markey, Mark J Mandel
Bacterial strain variation exists in natural populations of bacteria and can be generated experimentally through directed or random mutation. The advent of rapid and cost-efficient whole-genome sequencing has facilitated strain-level genotyping. Even with modern tools, however, it often remains a challenge to map specific traits to individual genetic loci, especially for traits that cannot be selected under culture conditions (e.g., colonization level or pathogenicity). Using a combination of classical and modern approaches, we analyzed strain-level variation in Vibrio fischeri and identified the basis by which some strains lack the ability to utilize glycerol as a carbon source...
March 2015: Journal of Bacteriology
https://www.readbyqxmd.com/read/25063005/can-mild-bilateral-sensorineural-hearing-loss-affect-developmental-abilities-in-younger-school-age-children
#17
Sanja Doković, Milica Gligorović, Sanja Ostojić, Nadežda Dimić, Marina Radić-Šestić, Svetlana Slavnić
The research study was conducted for the purpose of examining the influence of mild bilateral sensorineural hearing loss (MBSNHL) on developmental abilities of younger school-age children. The sample encompassed 144 children with MBSNHL, aged 7.5-11 (M = 8.85). MBSNHL (20-40 dB HL) was identified by pure tone audiometry. The control group encompassed 160 children with normal hearing. The Acadia test of developmental abilities was used for assessment of developmental abilities. Although statistically significant differences between participants with MBSNHL and those with normal hearing were established in the majority of estimated developmental abilities domains, those differences do not indicate any significant delay in development of assessed abilities, except in the domain of auditory discrimination...
October 2014: Journal of Deaf Studies and Deaf Education
https://www.readbyqxmd.com/read/24665807/executive-functions-as-predictors-of-visual-motor-integration-in-children-with-intellectual-disability
#18
Haris Memisevic, Osman Sinanovic
The goal of this study was to assess the relationship between visual-motor integration and executive functions, and in particular, the extent to which executive functions can predict visual-motor integration skills in children with intellectual disability. The sample consisted of 90 children (54 boys, 36 girls; M age = 11.3 yr., SD = 2.7, range 7-15) with intellectual disabilities of various etiologies. The measure of executive functions were 8 subscales of the Behavioral Rating Inventory of Executive Function (BRIEF) consisting of Inhibition, Shifting, Emotional Control, Initiating, Working memory, Planning, Organization of material, and Monitoring...
December 2013: Perceptual and Motor Skills
https://www.readbyqxmd.com/read/24183563/pimavanserin-for-patients-with-parkinson-s-disease-psychosis-a-randomised-placebo-controlled-phase-3-trial
#19
RANDOMIZED CONTROLLED TRIAL
Jeffrey Cummings, Stuart Isaacson, Roger Mills, Hilde Williams, Kathy Chi-Burris, Anne Corbett, Rohit Dhall, Clive Ballard
BACKGROUND: Parkinson's disease psychosis, which includes hallucinations and delusions, is frequent and debilitating in people with Parkinson's disease. We aimed to assess safety and efficacy of pimavanserin, a selective serotonin 5-HT2A inverse agonist, in this population. METHODS: In our 6 week, randomised, double-blind, placebo-controlled study, we enrolled adults (aged ≥40 years) with Parkinson's disease psychosis. Antipsychotic treatments were not permitted during the study, but controlled antiparkinsonian medication or deep brain stimulation was allowed...
February 8, 2014: Lancet
https://www.readbyqxmd.com/read/24029852/correspondence-by-charles-t-jackson-containing-the-earliest-known-illustrations-of-a-morton-ether-inhaler
#20
Rajesh P Haridas, George S Bause
A letter, dated December 1, 1846, from Charles T. Jackson, MD, to Josiah D. Whitney contains a previously unreported description of a Morton ether inhaler and the only known contemporaneous hand-drawn illustrations of this type of ether inhaler. This letter and 2 other known letters on ether anesthesia were probably carried from Boston, MA, to Liverpool, United Kingdom, on the same paddle steamer (Acadia) that carried the well-known letter from Jacob Bigelow, MD, to Francis Boott, MD.
November 2013: Anesthesia and Analgesia
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