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https://www.readbyqxmd.com/read/29732472/how-training-citizen-scientists-affects-the-accuracy-and-precision-of-phenological-data
#1
Richard E Feldman, Irma Žemaitė, Abraham J Miller-Rushing
Monitoring plant and animal phenology is a critical step to anticipating and predicting changes in species interactions and biodiversity. Because phenology necessarily involves frequent and repeated observations over time, citizen scientists have become a vital part of collecting phenological data. However, there is still concern over the accuracy and precision of citizen science data. It is possible that training citizen scientists can improve data quality though there are few comparisons of trained and untrained citizen scientists in the ability of each to accurately and precisely measure phenology...
May 7, 2018: International Journal of Biometeorology
https://www.readbyqxmd.com/read/29652237/failure-of-facet-replacement-system-with-metal-on-metal-bearing-surface-and-subsequent-discovery-of-cobalt-allergy-report-of-2-cases
#2
Matthew L Goodwin, William Ryan Spiker, Darrel S Brodke, Brandon D Lawrence
The aim of this study was to report on 2 patients in whom metal-on-metal (MOM) facet replacements failed, with subsequent positive findings on allergy testing. Motion-preserving devices have been used with limited success when instrumentation is indicated in the mobile spine. MOM-bearing surfaces in orthopedics were developed to increase implant longevity, yet have been associated with numerous adverse outcomes, including local tissue reactions, pseudotumors, metallosis, and the need for revision surgery. Five patients with spinal stenosis and low-grade spondylolisthesis were randomized to undergo facet replacement surgery with the ACADIA facet replacement system at the authors' institution...
April 13, 2018: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/29549111/disrupting-the-three-dimensional-regulatory-topology-of-the-pitx1-locus-results-in-overtly-normal-development
#3
Richard Sarro, Acadia A Kocher, Deena Emera, Severin Uebbing, Emily V Dutrow, Scott D Weatherbee, Timothy Nottoli, James P Noonan
Developmental gene expression patterns are orchestrated by thousands of distant-acting transcriptional enhancers. However, identifying enhancers essential for the expression of their target genes has proven challenging. Maps of long-range regulatory interactions may provide the means to identify enhancers crucial for developmental gene expression. To investigate this hypothesis, we used circular chromosome conformation capture coupled with interaction maps in the mouse limb to characterize the regulatory topology of Pitx1 , which is essential for hindlimb development...
April 9, 2018: Development
https://www.readbyqxmd.com/read/29452684/evaluation-of-the-safety-tolerability-and-efficacy-of-pimavanserin-versus-placebo-in-patients-with-alzheimer-s-disease-psychosis-a-phase-2-randomised-placebo-controlled-double-blind-study
#4
Clive Ballard, Carol Banister, Zunera Khan, Jeffrey Cummings, George Demos, Bruce Coate, James M Youakim, Randall Owen, Srdjan Stankovic
BACKGROUND: Pimavanserin is a selective 5-HT2A receptor inverse agonist and antagonist approved in the USA for the treatment of hallucinations and delusions associated with Parkinson's disease psychosis. No safe or effective pharmacological treatment is approved for psychosis in patients with Alzheimer's disease. Therefore, we aimed to evaluate the safety, tolerability, and efficacy of pimavanserin versus placebo in patients with Alzheimer's disease psychosis. METHODS: We did a phase 2, randomised, double-blind, placebo-controlled, single-centre (with multiple affiliated nursing home sites across the UK) study...
March 2018: Lancet Neurology
https://www.readbyqxmd.com/read/28817967/pimavanserin-a-novel-antipsychotic-for-management-of-parkinson-s-disease-psychosis
#5
REVIEW
Yasaman Kianirad, Tanya Simuni
Parkinson's disease psychosis (PDP) may develop in up to 60% of Parkinson's patients and is associated with increased morbidity and mortality. It also correlates with depression and dementia, and can contribute to caregiver stress and burnout. Pimavanserin is the first FDA approved drug for the treatment of hallucinations and delusions associated with PDP. Areas covered: For this review, a MEDLINE literature search (via PubMed) and information provided by ACADIA Pharmaceuticals were used. This review will discuss the pathophysiology and current management of PDP...
November 2017: Expert Review of Clinical Pharmacology
https://www.readbyqxmd.com/read/28792100/understanding-sources-of-methylmercury-in-songbirds-with-stable-mercury-isotopes-challenges-and-future-directions
#6
Martin Tsz-Ki Tsui, Evan M Adams, Allyson K Jackson, David C Evers, Joel D Blum, Steven J Balogh
Mercury (Hg) stable isotope analysis is an emerging technique that has contributed to a better understanding of many aspects of the biogeochemical cycling of Hg in the environment. However, no study has yet evaluated its usefulness in elucidating the sources of methylmercury (MeHg) in songbird species, a common organism for biomonitoring of Hg in forested ecosystems. In the present pilot study, we examined stable mercury isotope ratios in blood of 4 species of songbirds and the invertebrates they are likely foraging on in multiple habitats in a small watershed of mixed forest and wetlands in Acadia National Park in Maine (USA)...
January 2018: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/28636480/the-emerging-role-of-pimavanserin-in-the-management-of-parkinson-s-disease-psychosis
#7
REVIEW
Neal Hermanowicz, Gustavo Alva, Fernando Pagan, Alberto J Espay, Amita Patel, Katya Cruz Madrid, Daniel Kremens, Jim Kenney, Sheila Arquette, Gary Tereso, Maria Lopes, Carolyn Farnum
A panel of experts drawn from neurology, psychiatry, geropsychiatry, geriatrics, and pharmacy representatives of 3 health plans convened in New York City on July 30, 2016, with the objective of sharing opinions, ideas, and information regarding the optimal management of Parkinson's disease psychosis (PDP). Three key points emerged from the discussion: (1) Because of the nature of Parkinson's disease and PDP, finding appropriate treatment can prove challenging; (2) emerging therapies may present an opportunity for effective disease management; and (3) moving forward, provider and patient education regarding PDP and available treatment options is essential for well-managed symptoms and better quality of life...
June 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28609939/additions-to-the-hydroids-cnidaria-hydrozoa-of-the-bay-of-fundy-northeastern-north-america-with-a-checklist-of-species-reported-from-the-region
#8
Dale R Calder
Two new species of hydroids, Eudendrium bleakneyi and Halecium praeparvum, are described from the Bay of Fundy. Fourteen others, Tubularia acadiae Petersen, 1990, Coryne pusilla Gaertner, 1774, Sarsia lovenii (M. Sars, 1846), Zanclea implexa (Alder, 1856), Corydendrium dispar Kramp, 1935, Rhizogeton fusiformis L. Agassiz, 1862, Bougainvillia muscus (Allman, 1863), Rhizorhagium roseum M. Sars, in G.O. Sars, 1874, Hydractinia symbiolongicarpus Buss & Yund, 1989, Eudendrium vaginatum Allman, 1863, Tiaropsis multicirrata (M...
April 24, 2017: Zootaxa
https://www.readbyqxmd.com/read/28333766/dietary-inadequacies-in-hiv-infected-and-uninfected-school-aged-children-in-johannesburg-south-africa
#9
Stephanie Shiau, Acadia Webber, Renate Strehlau, Faeezah Patel, Ashraf Coovadia, Samantha Kozakowski, Susan Brodlie, Michael T Yin, Louise Kuhn, Stephen M Arpadi
OBJECTIVES: The World Health Organization recommends that human immunodeficiency virus (HIV)-infected children increase energy intake and maintain a balanced macronutrient distribution for optimal growth and nutrition. Few studies have evaluated dietary intake of HIV-infected children in resource-limited settings. METHODS: We conducted a cross-sectional analysis of the dietary intake of 220 perinatally HIV-infected children and 220 HIV-uninfected controls ages 5 to 9 years in Johannesburg, South Africa...
September 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28025922/comprehensive-medication-reviews-in-long-term-care-facilities-history-of-process-implementation-and-2015-results
#10
Terrence E O'Shea, Barbara J Zarowitz, W Gary Erwin
BACKGROUND: Since 2013, Part D sponsors have been required to offer comprehensive medication reviews (CMRs) to all beneficiaries enrolled in their medication therapy management (MTM) programs at least annually, including those in long-term care (LTC) settings. Since that time, MTM providers have found that accessing and completing CMRs with beneficiaries is frequently prohibitively complex, since the process often requires a live, face-to-face interactive interview where the beneficiary resides...
January 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/27761878/moderate-endoplasmic-reticulum-stress-activates-a-perk-and-p38-dependent-apoptosis
#11
Emily C Lumley, Acadia R Osborn, Jessica E Scott, Amanda G Scholl, Vicki Mercado, Young T McMahan, Zachary G Coffman, Jay L Brewster
The endoplasmic reticulum (ER) has the ability to signal organelle dysfunction via a complex signaling network known as the unfolded protein response (UPR). In this work, hamster fibroblast cells exhibiting moderate levels of ER stress were compared to those exhibiting severe ER stress. Inhibition of N-linked glycosylation was accomplished via a temperature-sensitive mutation in the Dad1 subunit of the oligosaccharyltransferase (OST) complex or by direct inhibition with tunicamycin (Tm). Temperature shift (TS) treatment generated weak activation of ER stress signaling when compared to doses of Tm that are typically used in ER stress studies (500-1000 nM)...
January 2017: Cell Stress & Chaperones
https://www.readbyqxmd.com/read/27703782/ketamine-stimulating-antidepressant-treatment
#12
EDITORIAL
Gin S Malhi, Yulisha Byrow, Frederick Cassidy, Andrea Cipriani, Koen Demyttenaere, Mark A Frye, Michael Gitlin, Sidney H Kennedy, Terence A Ketter, Raymond W Lam, Rupert McShane, Alex J Mitchell, Michael J Ostacher, Sakina J Rizvi, Michael E Thase, Mauricio Tohen
SUMMARY: The appeal of ketamine - in promptly ameliorating depressive symptoms even in those with non-response - has led to a dramatic increase in its off-label use. Initial promising results await robust corroboration and key questions remain, particularly concerning its long-term administration. It is, therefore, timely to review the opinions of mood disorder experts worldwide pertaining to ketamine's potential as an option for treating depression and provide a synthesis of perspectives - derived from evidence and clinical experience - and to consider strategies for future investigations...
May 2016: BJPsych Open
https://www.readbyqxmd.com/read/27609312/pimavanserin-for-the-treatment-of-parkinson-s-disease-psychosis
#13
REVIEW
Ines Chendo, Joaquim J Ferreira
INTRODUCTION: Parkinson´s disease (PD) is a synucleinopathy that affects millions of people worldwide and leads to progressive disability. Psychosis is highly prevalent in PD patients and is associated with poor prognosis. Until April 2016, there were no licensed drugs available in the United States of America (USA) for the treatment of PD psychosis (PDP). Pimavanserin is the first Food and Drug Administration approved medicine for the treatment of hallucinations and delusions associated with PDP...
October 2016: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/27361847/the-effect-of-performance-enhancing-clothing-on-dynamic-balance-a-randomized-double-blind-study-3278-board-343-june-3-3-30-pm-5-00-pm
#14
Anna M McGarr, Christopher Villarosa, Toshiki Kobayashi, Laura J Davis, Acadia L Clohesey, Michelle E Judge, Miran D McCash, Juhanna T Roberts, Claudia Espina Bresnahan, Michael S Orendurff
No abstract text is available yet for this article.
May 2016: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/27361844/the-effect-of-technology-enhanced-clothing-on-low-back-and-hamstring-flexibility-3275-board-340-june-3-3-30-pm-5-00-pm
#15
Acadia L Clohesey, Michelle E Judge, Miran D McCash, Juhanna T Roberts, Claudia Espina Bresnahan, Anna M McGarr, Christopher Villarosa, Toshiki Kobayashi, Laura J Davis, Michael S Orendurff
No abstract text is available yet for this article.
May 2016: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/27361843/the-effect-of-microclimate-enhanced-clothing-on-grip-strength-a-randomized-double-blind-study-3274-board-339-june-3-3-30-pm-5-00-pm
#16
Miran D McCash, Juhanna T Roberts, Claudia Espina Bresnahan, Anna M McGarr, Christopher Villarosa, Toshiki Kobayashi, Laura J Davis, Acadia L Clohesey, Michelle E Judge, Michael S Orendurff
No abstract text is available yet for this article.
May 2016: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/27360512/unique-balance-domains-for-balance-error-scoring-system-bess-and-y-balance-tests-1593-board-246-june-2-9-00-am-10-30-am
#17
Laura J Davis, Anna M McGarr, Claudia Espina Bresnahan, Acadia L Clohesey, Michelle E Judge, Miran D McCash, Juhanna T Roberts, Christopher Villarosa, Toshiki Kobayashi, Michael S Orendurff
No abstract text is available yet for this article.
May 2016: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/27360167/effects-of-performance-enhancing-clothing-on-cardiovascular-endurance-a-randomized-double-blind-study-with-deception-1024-board-340-june-1-2-00-pm-3-30-pm
#18
Michelle E Judge, Anna M McGarr, Christopher Villarosa, Toshiki Kobayashi, Laura J Davis, Acadia L Clohesey, Miran D McCash, Juhanna T Roberts, Claudia Espina Bresnahan, Michael S Orendurff
No abstract text is available yet for this article.
May 2016: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/27360117/a-randomized-double-blind-protocol-with-deception-to-evaluate-claims-of-balance-improvement-by-enhanced-clothing-974-board-290-june-1-3-30-pm-5-00-pm
#19
Claudia Espina Bresnahan, Anna M McGarr, Christopher Villarosa, Toshiki Kobayashi, Laura J Davis, Acadia L Clohesey, Michelle E Judge, Miran D McCash, Juhanna T Roberts, Michael S Orendurff
No abstract text is available yet for this article.
May 2016: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/27262680/pimavanserin-first-global-approval
#20
REVIEW
Anthony Markham
Pimavanserin (Nuplazid™) is a selective and potent serotonin 2A (5-HT2A) receptor inverse agonist and antagonist developed by ACADIA Pharmaceuticals that has been approved in the US as a treatment for patients with hallucinations and delusions associated with Parkinson's disease psychosis. Up to 60 % of patients with Parkinson's disease may develop Parkinson's disease psychosis, which is associated with increased morbidity and mortality and has few treatment options. This article summarizes the milestones in the development of pimavanserin leading to this first approval for the treatment of hallucinations and delusions in patients with Parkinson's disease psychosis...
July 2016: Drugs
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