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https://www.readbyqxmd.com/read/29143702/association-between-altered-neurochemical-metabolites-and-apathy-in-patients-with-alzheimer-s-disease
#1
Yi-Chun Yeh, Chun-Wei Li, Yu-Ting Kuo, Mei-Feng Huang, Tai-Ling Liu, Twei-Shiun Jaw, Yi-Hsin Yang, Kuang-Che Kuo, Cheng-Sheng Chen
BACKGROUND: Apathy is a condition characterized by a lack of motivation that manifests in emotional, behavioral, and cognitive domains. Although previous studies have indicated that apathy is associated with frontal lesions, few studies have focused on the different subdomains of apathy, and no in vivo human biochemical data have been obtained to examine the neurochemical changes related to apathy in patients with Alzheimer's disease (AD). Thus, we investigated the frontal neurochemical alterations related to apathy among patients with AD using proton magnetic resonance spectroscopy (1H MRS)...
November 16, 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/29131467/central-mucoepidermoid-carcinoma-arising-from-glandular-odontogenic-cyst-confirmed-by-analysis-of-maml2-rearrangement-a-case-report
#2
Atsuhiro Nagasaki, Ikuko Ogawa, Yukiko Sato, Kengo Takeuchi, Masae Kitagawa, Toshinori Ando, Shinnichi Sakamoto, Madhu Shrestha, Kaori Uchisako, Koichi Koizumi, Shigeaki Toratani, Masaru Konishi, Takashi Takata
Central mucoepidermoid carcinoma (MEC) poses a diagnostic challenge because of its rarity and histological overlap with glandular odontogenic cyst (GOC). In MEC of both salivary glands and jaws, MAML2 arrangement has been well known as the specific gene alteration. We report a case of central MEC arising from GOC diagnosed by MAML2 fusion gene. A 57-year-old male presented a multilocular cystic lesion in left molar region of the mandible. Histopathologically, multiple cysts lined by thin cuboidal or non-keratinized squamous epithelium with small duct-like structures, mucous cells and ciliated cells were present...
November 13, 2017: Pathology International
https://www.readbyqxmd.com/read/29126489/dental-treatment-planning-for-the-patient-with-oral-cancer
#3
REVIEW
Lauren E Levi, Rajesh V Lalla
Oral cancer therapy is associated with a multitude of head and neck sequelae that includes, but is not limited to, hyposalivation, increased risk for dental caries, osteoradionecrosis of the jaw, radiation fibrosis syndrome, mucositis, chemotherapy-induced neuropathy, dysgeusia, dysphagia, mucosal lesions, trismus, and infections. Preparing a comprehensive treatment plan for patients undergoing cancer therapy is essential to help minimize their risks for developing these oral and dental complications. In addition, dentists must take into account a patient's ongoing oncologic therapy for those patients who present to the dentist while concurrently receiving cancer treatment...
January 2018: Dental Clinics of North America
https://www.readbyqxmd.com/read/29123273/in-vivo-imaging-of-the-microvasculature-of-the-soft-tissue-margins-of-osteonecrotic-jaw-lesions
#4
P Bastos, V Patel, F Festy, N Hosny, R J Cook
Introduction Given the increasing incidence of medication-related jaw osteonecrosis, and recognition of the mucosal blood supply's importance, we have developed a non-invasive Real Time Optical Vascular Imaging (RTOVI) instrument. Imaging the red blood cells within the sub-mucosal capillary networks demonstrates the microcirculatory anatomy. We report a small trial, demonstrating the technique's viability, examining mucosal microcirculatory changes adjacent to osteonecrotic lesions.Aims Imaging the microvasculature of soft tissue margins of patients' exposed necrotic bone lesions in situ was intended to provide unique observational as well as quantitative data, using an image analysis routine, based on ImageJ software...
November 10, 2017: British Dental Journal
https://www.readbyqxmd.com/read/29113208/calcifying-cystic-odontogenic-tumor-accompanied-by-a-dentigerous-cyst-a-case-report
#5
Shoko Gamoh, Hironori Akiyama, Chisato Furukawa, Yuki Matsushima, Tomio Iseki, Masahiro Wato, Akio Tanaka, Shosuke Morita, Kimishige Shimizutani
A calcifying cystic odontogenic tumor (CCOT) is a proliferation of odontogenic epithelium and scattered nests of ghost cells and calcifications that may form the lining of a cyst, or present as a solid mass. It was previously described by Gorlin et al in 1962 as a calcifying odontogenic cyst. Dentigerous cysts are developmental odontogenic jaw cysts, commonly manifesting in the second and third decades of life. The present study reports an asymptomatic case in a 13-year-old boy who was referred to the outpatient clinic of the Osaka Dental University Hospital (Osaka, Japan) for additional investigation of an area of radiolucency in the lower right jaw...
November 2017: Oncology Letters
https://www.readbyqxmd.com/read/29110925/a-novel-imrt-planning-study-by-using-the-fixed-jaw-method-in-the-treatment-of-peripheral-lung-cancer-with-mediastinal-lymph-node-metastasis
#6
Hao Wang, Hua Chen, Hengle Gu, Yan Shao, Xuwei Cai, Xiaolong Fu, Zhiyong Xu
Intensity-modulated radiotherapy (IMRT) is an important technology in cancer radiotherapy. In the current planning system, such as in the Pinnacle(3) system, jaw positions are automatically set to cover all target volumes, and many medical centers in developing countries are not equipped with linear accelerators with a jaw tracing function. As solitary lesions are often located in patients, the resulting radiation leakage and transmission increase the dose exposure in surrounding critical organs, although blocked by multileaf collimator (MLC) leaves...
October 27, 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/29109954/role-of-periapical-diseases-in-medication-related-osteonecrosis-of-the-jaws
#7
Nian Jing Rao, Jing Yi Wang, Ru Qing Yu, Yiu Yan Leung, Li Wu Zheng
Objective: The present study aimed to investigate the role of periapical diseases in inducing medication-related osteonecrosis of the jaws (MRONJ) using an ovariectomized (OVX) mice model. Materials and Methods: Twenty C57BL/6N female mice were randomly assigned to two groups. All mice were subjected to bilateral ovariectomy and then treated with oncologic dose of zoledronic acid (ZA) or vehicle for twelve weeks. Eight weeks after commence of drug administration, a pulpal exposure (PE) operation was performed on the first right lower molar to induce periapical periodontitis; the contralateral non-PE tooth was used as control...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29109847/the-pull-through-technique-a-viable-option-for-preserving-the-inferior-alveolar-nerve-during-surgical-resection
#8
REVIEW
Gustavo Boehmer Leite, Suelen Cristina Sartoretto, Fernando César Amazonas Lima, Mônica Calasans-Maia, Rafael Seabra Louro
The aim of this study was to present a new surgical technique used to remove benign mandibular tumors with minimal damage to the inferior alveolar nerve. The pull-through technique was shown using an ameloblastoma surgical resection as an example. This technique consisted in the reconstruction of the lower jaw associating the resection of the lesion with nerve repair at the same surgical time. The resection was performed using the pull-through technique and the inferior alveolar nerve was preserved. After 6 months, the patient presented a recovery of approximately 80% of sensory function...
December 2017: Craniomaxillofacial Trauma & Reconstruction
https://www.readbyqxmd.com/read/29109842/submental-perforator-flap-for-soft-tissue-reconstruction-in-bisphosphonate-related-osteonecrosis-of-the-jaws
#9
Jose-Antonio García-de Marcos, Juan Rey-Biel
Bisphosphonate-related osteonecrosis of the jaws (BRONJ) has emerged as an important and increasingly common comorbidity, especially in patients undergoing long-term treatment with high doses of bisphosphonates. The management of BRONJ remains controversial. Surgical treatment is necessary in severe cases. Treatment of the bone requires sequestrectomy or resection. Given the lack of sufficient mucosa to perform the operation and fragility of margins in many patients, local flaps are crucial. We report two cases of stage-3 BRONJ presenting secondary infection with Actinomyces , receiving treatment consisting of marginal resection of the necrotic bone, reinforcement with a reconstruction plate, and reconstruction of soft tissues using a submental perforator artery flap ipsilateral to the lesion...
December 2017: Craniomaxillofacial Trauma & Reconstruction
https://www.readbyqxmd.com/read/29099374/traumatic-bone-cyst-of-an-anterior-mandible-with-previous-symphyseal-fracture-in-a-pediatric-patient-a-rare-finding-and-etiopathologic-correlation
#10
Kumar Nilesh, Aaditee V Vande, Shivsagar Tewary, K V Suresh
Traumatic bone cysts (TBCs) are uncommon intraosseous lesions, classified as pseudocysts because they lack an epithelial membrane lining. The etiology of a pseudocyst has not been determined. Various hypotheses have been put forward to explain its pathogenesis, of which the traumatic-hemorrhagic theory is the most commonly accepted. Minor trauma, insufficient to cause fracture or iatrogenic injury, is commonly implicated as the stimulus initiating cyst formation. A TBC presenting after jaw fracture has been rarely reported in the literature...
November 2017: General Dentistry
https://www.readbyqxmd.com/read/29074442/conservative-management-of-an-atypical-intra-sinusal-ossifying-fibroma-associated-to-an-aneurysmal-bone-cyst
#11
R Saad, J-C Lutz, S Riehm, L Marcellin, C-I Gros, F Bornert
Ossifying fibroma (OF) is a benign fibro-osseous lesion mainly occurring in young adults and seems to originate from the periodontal ligament. Aneurysmal bone cyst (ABC) is a benign intraosseous lesion characterized by blood-filled spaces of various sizes. These two lesions can specifically affect the jaws and are commonly described in the literature. However, few cases describing an association of OF and ABC have been reported in the literature, especially in the maxillary sinus. We report the case of a 40-year-old male patient affected with an asymptomatic lesion with a dual component of OF and ABC laying in the maxillary sinus...
October 24, 2017: Journal of Stomatology, Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29072378/-primary-and-secondary-hyperparathyroidism-presenting-as-brown-tumor
#12
Avraham Toeg, Victoria Yaffe-Gartsbein, Omri Emodi, Imad Abu El-Naaj
Hyperparathyroidism (HPT) may lead to the formation of osteolytic lesions with giant granulomas. Giant cell lesions associated with HPT are known as brown tumor and represent an end stage complication of HPT. Brown tumors affect the mandible, clavicles, ribs and pelvis. Maxillary involvement is rare. We present two cases of brown tumor: the first is a case of primary HPT involving the maxilla and the second case is secondary HPT involving the mandible. Differential diagnosis, work up and methods of management of the jaw lesions are discussed...
October 2017: Harefuah
https://www.readbyqxmd.com/read/29072251/conservative-surgical-treatment-of-the-jaw-cysts-in-children-case-study-of-five-patients
#13
G Gurler, S Yilmaz, C Delilbasi, E Dilaver, E Yuzbasioglu, A Patir-Munevveroglu
AIMS: Conservative treatment of jaw cysts establishes low surgical complication risk and protects vital anatomical structures such as inferior alveolar nerve, maxillary sinus and permanent tooth germs. Marsupialization and decompression have been widely used in children. The aim of this study was to evaluate the results of the conservative treatment of jaw cysts in five children. MATERIALS AND METHODS: This article presents case series of marsupialization in jaw cysts associated with impacted teeth in five children...
September 2017: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/29064415/solitary-intra-osseous-myofibroma-of-the-jaw-a-case-report-and-review-of-literature
#14
Anita Dhupar, Karla Carvalho, Poonam Sawant, Anita Spadigam, Shaheen Syed
Myofibroma is a rare benign spindle cell neoplasm in children that usually affects both soft tissue and bone in the head and neck region. Approximately one third of these cases are seen within jaw bones as solitary lesions. Solitary intra-osseous myofibroma of the jaw bone shares its clinical, radiographic and histological features with other spindle cell tumors. The rarity of this lesion can make diagnosis difficult for clinicians and pathologists. We report a case of a solitary intra-osseous myofibroma in the mandible of a nine-year-old child...
October 24, 2017: Children
https://www.readbyqxmd.com/read/29058839/-cone-beam-ct-new-tool-in-diagnostic-imaging
#15
M De Marneffe, M Milicevic, M Milicevic
The goal of this article is to show the advantages of the Cone Beam Computerized Tomography (CBCT) compared to classical Computerized Tomography (CT) and to describe several clinical applications of interest with this rather new technology. Invented practically for dentistry, in particular in implantology, the CBCT found major indications in paranasal sinus imaging, in maxillofacial and oral surgery, in periodontology, endodontics and orthodontics. CBCT is very useful to characterize various lesions of jaws with a reserve concerning the study of soft tissues (in that case, an MRI or CT with contrast injection should be preferred)...
October 2017: Revue Médicale de Liège
https://www.readbyqxmd.com/read/29055436/brain-white-matter-demyelinating-lesions-and-amyotrophic-lateral-sclerosis-in-a-patient-with-c9orf72-hexanucleotide-repeat-expansion
#16
Miguel Oliveira Santos, Inês Caldeira, Marta Gromicho, Ana Pronto-Laborinho, Mamede de Carvalho
A hexanucleotide repeat expansion in the C9orf72 gene is associated with amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration. It has been described before four patients with multiple sclerosis (MS) and C9orf72-ALS. However, C9orf72 positivity is not associated with increased risk of MS. Inflammatory pathways related to NF-κB have been linked to ALS and MS, and appear to be important in C9orf72-ALS patients. A 42-year-old woman presented with progressive bulbar symptoms for 9 months. Neurological examination disclosed spastic dysarthria, atrophic tongue with fasciculations, brisk jaw and limb tendon reflexes, and bilateral Hoffman sign...
October 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29053654/retrospective-analysis-of-jaw-biopsies-in-young-adults-a-study-of-1599-cases-in-southern-brazil
#17
K Silva, A Alves, M Correa, A Etges, A-C Vasconcelos, A-P Gomes, S Tarquinio
BACKGROUND: To evaluate the prevalence and the characteristics of jaw lesions diagnosed in young adults aged 20 to 30 years in a southern Brazil reference center, over a period of 25 years. And to analyze the concordance between clinical and histological diagnosis. MATERIAL AND METHODS: In this cross-sectional retrospective study, the biopsies files from this center were retrieved and data regarding sex, age, bone localization, clinical and histological diagnosis were collected...
November 1, 2017: Medicina Oral, Patología Oral y Cirugía Bucal
https://www.readbyqxmd.com/read/29046963/cone-beam-computed-tomography-and-ultrasonography-imaging-of-benign-intraosseous-jaw-lesion-a-prospective-radiopathological-study
#18
Ibrahim Sevki Bayrakdar, Ahmet Berhan Yilmaz, Fatma Caglayan, Umit Ertas, Cemal Gundogdu, Ismail Gumussoy
OBJECTIVE: We assessed whether ultrasonography (US) can be used in combination with cone beam computed tomography (CBCT) to image intraosseous jaw lesions. MATERIAL AND METHODS: Using CBCT and US, we evaluated 123 lytic intraosseous jaw lesions diagnosed in 121 patients with guidance from the CBCT findings. The lesions were classified into two groups based on histopathological evaluation: (1) cysts and (2) tumors and tumor-like lesions. US and histopathological findings on the lesions of the two groups and their relationships with each other were also assessed...
October 18, 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/29046640/antiparkinsonian-efficacy-of-guanosine-in-rodent-models-of-movement-disorder
#19
Caio M Massari, Marc López-Cano, Fabiana Núñez, Víctor Fernández-Dueñas, Carla I Tasca, Francisco Ciruela
Guanosine (GUO) is a guanine-based purine nucleoside with important trophic functions and promising neuroprotective properties. Although the neuroprotective effects of GUO have been corroborated in cellular models of Parkinson's disease (PD), its efficacy as an antiparkinsonian agent has not been fully explored in PD animal models. Accordingly, we evaluated the effectiveness of GUO in reversing motor impairments in several rodent movement disorder models, including catalepsy, tremor, and hemiparkinsonism. Our results showed that orally administered GUO antagonized reserpine-mediated catalepsy, reduced reserpine-induced tremulous jaw movements, and potentiated the number of contralateral rotations induced by L-3,4-dihydroxyphenylalanine in unilaterally 6-hydroxidopamine-lesioned rats...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29045089/an-osteoblastoma-of-the-mandible-a-case-study
#20
Ahmad Abdelkarim
This case study involves a 22-year-old male who experienced moderate pain in the left side of the mandible for two months. He was diagnosed with an osteoblastoma and treated with local excision, curettage and extraction of the involved teeth. Radiographic follow-up indicated that the site healed well. Clinical, radiographic and histopathologic features are discussed. Osteoblastoma requires interdisciplinary care and should be considered in the differential diagnosis of mixed-density lesions detected in the jaws...
December 2016: Journal of the California Dental Association
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