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Oral Hemangioma

Saul Castaneda, Esbeydy Garcia, Hermelinda De la Cruz, Oscar Ramirez, Samuel Melendez, Jose Sanchez-Palacio
BACKGROUND: Infantile hemangiomas are the most common childhood vascular tumors, occurring in 10 % of children aged less than 1 year. Propranolol, a β-adrenergic blocker mainly indicated for hypertension, has proven effective in treating these types of tumors. OBJECTIVE: To evaluate the efficacy and adverse effects of propranolol in Mexican pediatric patients diagnosed with infantile hemangioma, treated with an extemporaneously compounded solution of propranolol...
March 2016: Drugs—Real World Outcomes
Christine Léaute-Labrèze, Olivia Boccara, Caroline Degrugillier-Chopinet, Juliette Mazereeuw-Hautier, Sorilla Prey, Geneviève Lebbé, Stéphanie Gautier, Valérie Ortis, Martine Lafon, Agnès Montagne, Alain Delarue, Jean-Jacques Voisard
BACKGROUND AND OBJECTIVES: Given the widespread use of propranolol in infantile hemangioma (IH) it was considered essential to perform a systematic review of its safety. The objectives of this review were to evaluate the safety profile of oral propranolol in the treatment of IH. METHODS: We searched Embase and Medline databases (2007-July 2014) and unpublished data from the manufacturer of Hemangiol/Hemangeol (marketed pediatric formulation of oral propranolol; Pierre Fabre Dermatologie, Lavaur, France)...
September 29, 2016: Pediatrics
Graham M Strub, Andrew L Kirsh, Mark E Whipple, Winston P Kuo, Rachel B Keller, Raj P Kapur, Mark W Majesky, Jonathan A Perkins
Infantile hemangioma (IH) is the most common vascular tumor of infancy, and it uniquely regresses in response to oral propranolol. MicroRNAs (miRNAs) have emerged as key regulators of vascular development and are dysregulated in many disease processes, but the role of miRNAs in IH growth has not been investigated. We report expression of C19MC, a primate-specific megacluster of miRNAs expressed in placenta with rare expression in postnatal tissues, in glucose transporter 1-expressing (GLUT-1-expressing) IH endothelial cells and in the plasma of children with IH...
2016: JCI Insight
A Nagaraja, N Govindraj Kumar, B Jambukeshwar Kumar, Raghavendra M Naik, Y Jyoti Sangineedi
Pathological conditions can give rise to calcifications within oral mucosa representing either a local or systemic disturbance. Inflammation, trauma, debris acting as nidus and vascular lesions have been attributed as principal causes for occurrence of calcifications within the oral mucosa. Occurrence of multiple calcified thrombi (phleboliths) is considered pathognomonic for hemangiomas and vascular malformations in the oral and maxillofacial region. Isolated occurrence of phlebolith in oral mucosa though very rare, especially without any underlying vascular lesions, can be diagnostically challenging...
2016: Journal of Contemporary Dental Practice
Jia-Wei Zheng, Xu-Kai Wang, Zhong-Ping Qin, Xin-Dong Fan, Kai Li, Yao-Wu Yang, Ran Huo, Shao-Hua Liu, Ji-Hong Zhao, Xiao-Yong Wang, De-Kai Zhou
Infantile hemangioma (IH) is one of the most common benign vascular tumors in children. A variety of treatment methods have been documented for the management of IH over the past years, including pharmacotherapy via oral administration or injection of corticosteroids, vincristine, alpha interferon and bleomycin; laser therapy, radionuclide therapy, cryotherapy and excisional surgery. The therapeutic efficacy of each treatment modality is variable, while adverse effects or complications are common and sometimes serious...
June 2016: Shanghai Kou Qiang Yi Xue, Shanghai Journal of Stomatology
Melissa Rodrigues de Araujo, Sanaha Jomaa, Rafael Zancan Mobile, Lucas Caetano Uetanabaro, Allan Fernando Giovanini, Rafaela Scariot, Alexandre Moro
Vascular anomalies such as hemangiomas or vascular malformations can produce negative esthetic effects in the maxillofacial region. These negative effects are the main complaints of patients. The clinical therapeutic efficacy of cryotherapy and sclerotherapy in the treatment of these lesions was evaluated in 10 patients who were clinically diagnosed with vascular lesions. Lesions were submitted to either cryotherapy or sclerotherapy, and follow-up showed that cryotherapy and sclerotherapy both were clinically effective in treating oral vascular lesions...
September 2016: General Dentistry
Shuang Tong, Da-Peng Xu, Zi-Mei Liu, Yang Du, Xu-Kai Wang
The aim of the present study was to assess the efficacy and safety of topical timolol maleate combined with oral propranolol for parotid infantile hemangiomas. Between October 2012 and April 2014, propranolol was administered orally at a dose of 1.0-1.5 mg/kg/day to 22 infants with proliferating hemangiomas in the Department of Oral and Maxillofacial Surgery (Hospital of Stomatology, China Medical University, Shenyang, Liaoning, China). A small amount of 0.5% timolol maleate eye drop solution was topically applied with medical cotton swabs to the area of the lesion twice a day, every 12 h...
September 2016: Oncology Letters
Ting-Lin B Yang, Patrick McMahon, Diva D De Léon, James R Treat
Infantile hemangiomas (IHs) are the most common pediatric vascular tumors. They require therapy when they cause severe complications such as ulceration, amblyopia, or airway constriction. Propranolol is the only treatment that the U.S. Food and Drug Administration has approved for complicated IHs and has become first-line therapy for IHs that need to be treated. Older therapies such as systemic corticosteroids and surgery are now rarely used. Propranolol can have potentially serious adverse side effects, including bradycardia, hypotension, and hypoglycemia...
August 30, 2016: Pediatric Dermatology
Yi Ji, Siyuan Chen, Bo Xiang, Zhicheng Xu, Xiaoping Jiang, Xingtao Liu, Qi Wang, Guoyan Lu, Li Yang
Multifocal hepatic hemangioma (MHH) is a benign hepatic tumor that is commonly diagnosed in children with multiple cutaneous infantile hemangiomas (IHs). We present a review of all children with MHH at our institutions. Of the 42 patients, the median age at presentation of MHH was 2.5 months. Thirty-six (85.7%) patients had cutaneous IHs. Twelve (28.6%) patients were symptomatic at presentation. There was no significant association between the number of hepatic hemangiomas and the number of cutaneous IHs. Fourteen (33...
2016: Scientific Reports
Katherine Püttgen, Anne Lucky, Denise Adams, Elena Pope, Catherine McCuaig, Julie Powell, Dana Feigenbaum, Yulia Savva, Eulalia Baselga, Kristen Holland, Beth Drolet, Dawn Siegel, Kimberly D Morel, Maria C Garzon, Erin Mathes, Christine Lauren, Amy Nopper, Kimberly Horii, Brandon Newell, Wei Song, Ilona Frieden
BACKGROUND: There has been a dramatic increase in the off-label use of ophthalmic timolol maleate, a β-blocker used for infantile hemangioma (IH) treatment as a topical counterpart to oral propranolol. Its safety and efficacy in a pediatric population with IH have not been evaluated in a large cohort. Our goal was to retrospectively assess timolol's effectiveness, discern characteristics associated with response, and document reported adverse events. METHODS: A multicenter retrospective cohort study of 731 patients treated with topical timolol was completed at 9 centers...
September 2016: Pediatrics
Stephany Vasco Ferreira, Flávia Caló Aquino Xavier, Maria da Conceição Andrade de Freitas, Fábio Daumas Nunes, Clarissa Araújo Gurgel, Maria Cristina Teixeira Cangussu, Manoela Domingues Martins, Valéria Souza Freitas, Jean Nunes Dos Santos
In view of the similarity of clinicopathological features between reactive lesions of the oral cavity, the objective of the present study was to investigate the density of MCs (mast cells) and microvessels in a series of these lesions. Thirty-seven cases of reactive lesions including fibrous hyperplasia (FH, n=10), inflammatory fibrous hyperplasia (IFH, n=10), peripheral giant cell lesion (PGCL, n=10) and lobular capillary hemangioma (LCH, n=7) were investigated using immunohistochemistry for mast cell tryptase and CD34...
September 2016: Pathology, Research and Practice
Wenhao Ren, Shaoming Li, Ling Gao, Shuo Huang, Linmei Zhang, Cui Qiang, Chunxi Liu, Keqian Zhi
BACKGROUND: More and more infantile hemangiomas(IH) began to treat with propranolol, however the effectiveness, dosage, and treatment course were still in dispute. The objective of this observational study was to describe the therapeutic response, tolerance, and safety of low dose propranolol in 23 children with infantile hemangiomas on head and neck. METHODS: Data were collected from the medical charts of patients treated with low dose propranolol from December 2009 through November 2011...
July 30, 2016: Pediatrics International: Official Journal of the Japan Pediatric Society
Shigeyuki Furuta, Hideaki Sato, Shiho Tsuji, Fumiko Murakami, Hiroaki Kitagawa
PURPOSE: To investigate the efficacy of our treatment of infantile hemangioma (IH)s retrospectively presenting as disfiguring or functionally threatening lesions. MATERIALS AND METHODS: 25 infants with IH treated with long-pulsed dye laser or laser with or without propranolol. Tumor fading after treatment was evaluated using both color and size rating scales, before, during and after treatment. RESULTS: 6 infants were treated by laser, 11, oral propranolol and 8 using both treatments...
September 2016: Pediatric Surgery International
Kathryn Em French, Andrew M Felstead, Norman Haacke, Jeffery Theaker, Peter A Brennan, S D Colbert
BACKGROUND: Spindle cell hemangioma (SCH) is an uncommon benign vascular tumor that rarely occurs in the mouth. METHODS AND RESULTS: We present an SCH arising in the tongue of a 52-year-old otherwise healthy woman. SCH should be considered in the differential diagnosis of vascular tumors in the oral cavity and not misinterpreted as a more aggressive vascular tumor. We describe the clinical presentation, investigation, differential diagnosis and management of this condition and a literature search showing published case reports...
July 22, 2016: Journal of Cutaneous Pathology
Sormani Bento Fernandes de Queiroz, Valthierre Nunes de Lima, Pedro Henrique Gonçalves Holanda Amorim, Cristian Statkievicz, Osvaldo Magro-Filho
Adverse reactions related to ethanolamine oleate (EO) include pain during injection, redness, inflammation, tissue necrosis, and allergic reaction. The authors report a patient of exuberant facial edema after the injection of EO used in sclerotherapy of lip hemangioma in a child. A 9-year-old boy was referred to authors' oral and maxillofacial surgery unit to treat a vascular lesion of the upper lip. The lesion has causing enlargement of the middle area of the upper lip, being sessile and resilient by palpation...
September 2016: Journal of Craniofacial Surgery
Marshall W Meeks, Umar M Kamal, Muhammad B Hammami, Jason R Taylor, M Louay Omran, Yongxin Chen, Jin-Ping Lai
Pyogenic granuloma (PG), more accurately known as lobular capillary hemangioma, is a benign vascular tumor that usually occurs in the skin or oral mucosa. This lesion is rarely reported in the gastrointestinal tract but is known to bleed if not resected. We herein describe a case series with the clinical, endoscopic, and histologic findings of four cases of gastrointestinal PG at our institution. In addition, we provide a review of the literature and summation of all reported cases of PG specific to the gastrointestinal tract...
2016: Case Reports in Gastrointestinal Medicine
Sabri T Shuker
With the progress of multidisciplinary vascular anomaly treatment, the use of radiotherapy, cryotherapy, laser therapy and medical treatments, the corticosteroid, sclerotherapy, and many more, the role of surgery has been refined. Surgical treatment has historically been the mainstay of treatment and will maintain.A miniature tourniquet technique applied to the tongue was successfully utilized in reducing bleeding to a minimum during surgical resection of a massive cavernous hemangioma involving the tongue and lower lip without any postoperative complications...
July 2016: Journal of Craniofacial Surgery
Vinay Marla, Ashish Shrestha, Khushboo Goel, Sajeev Shrestha
Background. Pyogenic granuloma is a reactive tumor-like lesion commonly affecting the oral cavity. These lesions usually appear as localized solitary nodule with a sessile or pedunculated base and colour varying from red, purplish, or pink, depending on the vascularity of the lesion. Pyogenic granuloma shows predilection for gingiva and is usually slow growing, but at times it shows rapid growth. The natural course of this lesion can be categorized into three distinct phases, namely, (i) cellular phase, (ii) capillary phase/vascular phase, and (iii) involutionary phase...
2016: Case Reports in Dentistry
Silvia Tortorici, Salvatore Corrao, Giuseppe Natoli, Paolo Difalco
BACKGROUNG: The aim of the present study was to determine the prevalence of oral mucosal non-malignant lesions in the Sicilian population. In addition, we evaluated the association between each oral lesion and its risk factors. METHODS: This study analyzed a total of 2539 consecutive patients, attending the Department of Surgical, Oncological and Stomatological Disciplines of Palermo University, who were examined for the presence of various oral lesions during the period from January 2012 and February 2015...
August 2016: Minerva Stomatologica
Giovanna Stringari, Giulia Barbato, Matteo Zanzucchi, Maddalena Marchesi, Giuseppe Cerasoli, Bertrand Tchana, Alessandro Gritti, Valeria Boccaletti, Alfonsa Anna Lombardi, Nicola Carano
Infantile hemangiomas (IH) complicated by ulceration, disfigurement, functional impairment or life-threatening conditions need early, safe and effective treatment. This study explores the impact of propranolol on complicated IH. We report our experience of 62 patients treated with oral propranolol for complicated IH. The effect of propranolol was assessed using a score on a visual analogue scale integrated with echo, magnetic resonance or endoscopic findings. The average age at the beginning of the treatment was seven months [standard deviation (SD)±8...
2016: La Pediatria Medica e Chirurgica: Medical and Surgical Pediatrics
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