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Oral Hemangioma

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https://www.readbyqxmd.com/read/29771050/-fibrous-hemangioma-of-esophagus-portal-a-case-report
#1
Y P Wang, L X Li
A 33 year old male patient has found in the oral cavity tumor with nausea and vomiting after 20 days ago. The patients feel pharyngeal foreign body sensation, occasional sense of suffocation, the oropharyngeal tumor disappeared and foreign body sensation disappeared after swallowing. The patients without angina, no hemoptysis, no hoarseness, no acid reflux symptoms and weight loss phenomenon. The gastroscope showed giant tumor, esophagus smooth surface, visible local gray blue blood vessels, from the entrance of esophagus has been extended to the esophagus from the upper incisors 25 cm...
May 20, 2017: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29763352/pyogenic-granuloma-in-the-tongue-in-a-five-year-old-a-case-report
#2
Scott M Peters, David A Koslovsky, Angela J Yoon, Elizabeth M Philipone
Pyogenic granuloma, also called lobular capillary hemangioma, is a benign vascular lesion of the skin and mucous membranes. While the majority of pyogenic granulomas in the oral cavity involve the gingiva, they also infrequently present at other sites including lips, oral mucosa, palate, and tongue. We report a case of a pyogenic granuloma of the tongue in a five-year old female patient.
May 15, 2018: Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/29747482/effectiveness-of-oral-propranolol-for-infantile-hemangiomas-started-after-5-months-of-age
#3
Teresa Lopez, Emanuele Miraglia, Amalia Schiavetti, Giulia Varrasso, Stefano Calvieri, Sandra Giustini
No abstract text is available yet for this article.
May 10, 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29746707/population-pharmacokinetics-and-pharmacodynamics-of-oral-propranolol-in-pediatric-patients-with-infantile-hemangioma
#4
Tomoki Takechi, Tadao Kumokawa, Rumiko Kato, Takeshi Higuchi, Tsuyoshi Kaneko, Ichiro Ieiri
This study aimed to characterize the population pharmacokinetics and exposure-response relationship of propranolol (Hemangiol® Syrup for Pediatric) in infants with infantile hemangioma. Using nonlinear mixed-effects modeling with 63 pooled sets of plasma concentration-time data from 32 Japanese patients aged 35-150 days, we described the disposition of propranolol adequately by a 1-compartment model with first-order absorption. The estimated population mean apparent clearance and apparent central volume of distribution were 9...
May 10, 2018: Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29744569/widespread-and-debilitating-hemangiomas-in-a-patient-with-enchondromatosis-and-d-2-hydroxyglutaric-aciduria
#5
Patra Yeetong, Teerasak Phewplung, Wuttichart Kamolvisit, Kanya Suphapeetiporn, Vorasuk Shotelersuk
Metaphyseal chondromatosis with D-2-hydroxyglutaric aciduria (MC-HGA) (OMIM 614875) is a severe chondrodysplasia combined with a urinary excretion of D-2-hydroxyglutaric acid. Here, we reported the tenth case of this disease. A 15-year-old boy had symmetric radiolulencies in the metaphyses of the long bones suggesting enchondromatosis and platyspondyly. Remarkably, he manifested widespread cavernous hemangiomas including scalp, lips, tongue, larynx, and prepuce, with the onset of 3 years of age. Hemangiomas at the larynx had caused dyspnea and those in the oral cavity led to recurrent bleeding, requiring several surgical removals...
May 10, 2018: Skeletal Radiology
https://www.readbyqxmd.com/read/29737225/esophageal-pyogenic-granuloma-a-case-report-and-review-of-the-literature
#6
David A Suarez-Zamora, Paula A Rodriguez-Urrego, Jaime Solano-Mariño, Fernando Sierra-Arango, Mauricio A Palau-Lazaro
Pyogenic granuloma (PG) is a capillary hemangioma mainly found in the skin and oral mucosa, but rarely described in the esophagus. We report the case of a 66-year-old man who consulted for retrosternal pain. Endoscopic studies showed a 28-mm polypoid mass located at the distal esophageal mucosa. The patient underwent endoscopic resection, and the histopathological examination showed a neoplastic proliferation of small blood vessels growing in a lobular architecture, with edematous stroma and prominent inflammatory infiltrate...
May 1, 2018: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29736244/propranolol-pharmacokinetics-in-infants-treated-for-infantile-hemangiomas-requiring-systemic-therapy-modeling-and-dosing-regimen-recommendations
#7
Laurence Del Frari, Christine Léauté-Labrèze, Laurent Guibaud, Sébastien Barbarot, Jean-Philippe Lacour, Christine Chaumont, Alain Delarue, Jean-Jacques Voisard, Valérie Brunner
Propranolol has become the first choice therapy for complicated Infantile Hemangiomas (IH). The pharmacokinetics of propranolol were evaluated after repeated oral administration of a new pediatric solution of propranolol at 3 mg kg-1  day-1 given twice daily (BID) in infants (77-243 days) with IH. A population model was built to describe the pharmacokinetics of propranolol in infants and to simulate different dosing regimens. One hundred and sixty-seven plasma concentrations from 22 infants were used in the population analysis...
June 2018: Pharmacology Research & Perspectives
https://www.readbyqxmd.com/read/29706817/the-phaces-syndrome-multiple-episodes-of-reproliferation-of-subglottic-hemangioma
#8
Randall W Holdgraf, Melissa Kress
Subglottic hemangioma is a potentially life-threatening manifestation of the PHACES syndrome. The disease process has been treated with corticosteroids, oral chemotherapeutic agents, endoscopic airway interventions, tracheostomy, and even laryngotracheal reconstruction. Oral propranolol has emerged as an effective therapy and in many cases has led to complete regression of hemangioma during the proliferative phase. There have been several reports of patients showing signs of reproliferation after discontinuing propranolol therapy...
April 2018: Proceedings of the Baylor University Medical Center
https://www.readbyqxmd.com/read/29704808/lobular-capillary-hemangioma-of-the-mandible-a-case-report
#9
Cynthia Chan, Michael Iv, Nancy Fischbein, Hisham Dahmoush
Lobular capillary hemangiomas are acquired benign vascular neoplasms which typically affect the skin and mucous membranes. While these lesions commonly involve the head and neck, particularly the oral cavity, there are no reports in the literature of lobular capillary hemangioma arising from the mandible. The diagnosis of such a rare entity can therefore be challenging, especially as it may mimic more aggressive lesions, including malignancy. We present a rare case of an 8-year-old male with a lobular capillary hemangioma of the mandible, highlighting its imaging features and discussing the differential diagnosis of primary mandibular lesions in the pediatric population...
April 13, 2018: Clinical Imaging
https://www.readbyqxmd.com/read/29682550/effects-of-propranolol-on-neurodevelopmental-outcomes-in-patients-with-infantile-hemangioma-a-case-control-study
#10
Chuan Wang, Qi Wang, Bo Xiang, Siyuan Chen, Fei Xiong, Yi Ji
Background: The aim of this study was to examine whether oral propranolol has any effect on neurodevelopment outcomes in young children with problematic infantile hemangiomas (IHs). Methods: Thirty-six children with a diagnosis of problematic IH who were treated with oral propranolol were compared with 34 healthy children with no history of propranolol therapy. Patients received propranolol therapy for at least 3 months. Gesell developmental schedules (GDS) were used to evaluate neurodevelopment outcomes in the two groups...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29673261/medical-surgical-and-wound-care-management-of-ulcerated-infantile-hemangiomas-a-systematic-review
#11
Jane Y Wang, Arvin Ighani, Ana P Ayala, Sadanori Akita, Irene Lara-Corrales, Afsaneh Alavi
Ulcerated infantile hemangiomas may present a therapeutic challenge, especially if there is concurrent hemorrhage or infection. The aim of this study was to systematically review the published evidence on the treatment of ulcerated hemangiomas, focusing on wound healing as the outcome of interest. We searched MEDLINE, Embase, SCOPUS, Cumulative Index to Nursing and Allied Health Literature (CINAHL), and Web of Science from inception to July 2016. Seventy-seven studies met our inclusion criteria. One study was a randomized controlled trial, 30 were observational studies, and 46 were case reports or case series...
April 1, 2018: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/29651388/the-effect-of-oral-propranolol-versus-oral-corticosteroids-in-management-of-pediatric-hemangiomas
#12
Adil Ali, Umme Aiman, Mohd Azam Haseen, Mohd Altaf Mir, Imran Ghani, Ragya Bharadwaj, Mohd Yaseen
BACKGROUND: Hemangiomas are the most common benign tumors of infancy. This study evaluated the efficacy of oral propranolol comparing to oral steroids in management of pediatric hemangiomas. METHODS: In North India from January 2012 to January 2015, sixty children <6 years old with superficial hemangiomas were divided into 2 groups; oral propranolol vs. oral prednisolone. All participants were assessed for electrocardiogram, heart rate, blood pressure and sugar and initial therapy was started using 1 mg/kg and in absence of adverse effects, 2 mg/kg was administered after 2 weeks...
January 2018: World Journal of Plastic Surgery
https://www.readbyqxmd.com/read/29608474/cleft-palate-repair-using-single-flap-palatoplasty-in-patient-with-associated-palatal-hemangioma
#13
Murat Kara, Mert Calis, Canan Akyuz, Figen Ozgur
Hemangiomas are the most common tumors of childhood with an average incidence of 10%. It is unusual for hemangiomas, which are already rarely seen isolated on the palate, to coexist with cleft palate as in the authors' patient. Four months old baby was admitted with isolated Veau 2 cleft palate and a red-purple colored raised lesion involving almost the whole right side of the hard palate. Magnetic resonance imaging revealed intensive contrasting solid nodule with a lobulated contour that was covering the right half of the hard palate, measuring 2...
March 30, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29603774/thirty-two-japanese-cases-of-infantile-hemangiomas-treated-with-oral-propranolol
#14
Shinji Kagami, Masahide Kaneko, Tatsuo Katori
Infantile hemangiomas undergo rapid growth during early infancy followed by gradual involution. Infantile hemangiomas sometimes impair vital functions or cause disfigurement. Thirty-two Japanese patients between the ages of 1 and 4 months with proliferating infantile hemangiomas received oral propranolol on an outpatient basis. The success rate (complete or nearly complete resolution) at week 25 was 56% (18/32). Two patients dropped out because of a personal reason and moving out. Recurrence after termination of treatment was seen in six patients...
March 31, 2018: Journal of Dermatology
https://www.readbyqxmd.com/read/29537380/resolution-of-consumptive-hypothyroidism-secondary-to-infantile-hepatic-hemangiomatosis-with-combination-propranolol-and-levothyroxine
#15
V Campbell, R Beckett, N Abid, S Hoey
Infantile hepatic hemangiomas (IHH), particularly of the diffuse subtype, can in severe cases be associated with hepatic and cardiac failure, compartment syndrome, and consumptive hypothyroidism. Early recognition and treatment of these pathologies is paramount in order to minimise the risk of longterm sequelae. We report an interesting case of a female infant who presented with systemic compromise, in the absence of large or obvious cutaneous infantile hemangiomas (IH). Imaging identified innumerable hepatic hemangiomas, consistent with diffuse infantile hepatic hemangiomatosis...
February 28, 2018: Journal of Clinical Research in Pediatric Endocrinology
https://www.readbyqxmd.com/read/29465551/sirolimus-alternative-to-blood-transfusion-as-a-life-saver-in-blue-rubber-bleb-nevus-syndrome-a-case-report
#16
Ke-Ling Wang, Shu-Fang Ma, Ling-Yu Pang, Meng-Na Zhang, Lin-Yan Hu, Meng-Jia Liu, Li-Ping Zou
RATIONALE: Blue rubber bleb nevus syndrome (BRBNS) is a rare disease characterized by multiple venous malformations. The gastrointestinal bleeding and secondary iron deficiency anemia are the most common complications. There are currently no effective treatments for BRBNS. Here, we report a case of successful treatment with a small dose of sirolimus of a BRBN patient with a de novo gene mutation. PATIENT CONCERNS: A 12-year-old female was admitted to our hospital with multiple hemangiomas for 12 years...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29436111/a-biallelic-antxr1-variant-expands-the-anthrax-toxin-receptor-associated-phenotype-to-tooth-agenesis
#17
Nuriye Dinckan, Renqian Du, Zeynep C Akdemir, Yavuz Bayram, Shalini N Jhangiani, Harsha Doddapaneni, Jianhong Hu, Donna M Muzny, Yeliz Guven, Oya Aktoren, Hulya Kayserili, Eric Boerwinkle, Richard A Gibbs, Jennifer E Posey, James R Lupski, Zehra O Uyguner, Ariadne Letra
Tooth development is regulated by multiple genetic pathways, which ultimately drive the complex interactions between the oral epithelium and mesenchyme. Disruptions at any time point during this process may lead to failure of tooth development, also known as tooth agenesis (TA). TA is a common craniofacial abnormality in humans and represents the failure to develop one or more permanent teeth. Many genes and potentially subtle variants in these genes contribute to the TA phenotype. We report the clinical and genetic impact of a rare homozygous ANTXR1 variant (c...
April 2018: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/29405477/factors-associated-with-delayed-referral-for-infantile-hemangioma-necessitating-propranolol
#18
G Onnis, I Dreyfus, J Mazereeuw-Hautier
BACKGROUND: Oral propranolol is the gold standard to treat infantile hemangiomas. There is better efficacy and a lower risk of sequelae if therapy is started before the end of the growth phase, but most children are referred too late. Herein, we report the first study to investigate the delay and its associated factors when referring infants with infantile hemangiomas that need propranolol therapy. OBJECTIVES: The primary objective was to determine the delay in referral (time between age at referral [first phone contact] and the optimal age for referral (fixed at 75 days)...
February 6, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29377105/paediatric-oral-pathology-in-thailand-a-15-year-retrospective-review-from-a-medical-teaching-hospital
#19
Mana Taweevisit, Warisa Tantidolthanes, Somboon Keelawat, Paul Scott Thorner
OBJECTIVES: To determine whether the spectrum of oral pathology in children seen at a medical institution differs from studies derived from dental facilities. METHODS: Oral biopsy records from paediatric patients (<16 years of age) were retrieved from the pathology archives at Chulalongkorn University Hospital over a period of 15 years. Lesions were categorised as inflammatory/reactive, tumour/tumour-like or cystic. RESULTS: Two-hundred and thirty biopsies were identified...
January 28, 2018: International Dental Journal
https://www.readbyqxmd.com/read/29301720/effect-of-oral-propranolol-on-periocular-capillary-hemangiomas-of-infancy
#20
Kirthi Koka, Bipasha Mukherjee, Sumita Agarkar
BACKGROUND: To assess the safety and efficacy of oral propranolol in the management of periocular Capillary Hemangiomas of Infancy (CHI). METHODS: Medical records of 21 infants diagnosed with periocular capillary hemangioma during a period of 5 years from 2009 to 2014 were retrospectively reviewed. The data collected included demographic details, clinical features and details of imaging studies and response to the therapy. All patients received oral propranolol under the supervision of a pediatrician...
December 6, 2017: Pediatrics and Neonatology
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