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Oral Hemangioma

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https://www.readbyqxmd.com/read/28424095/safety-and-effectiveness-of-oral-propranolol-for-infantile-hemangiomas-started-before-5%C3%A2-weeks-and-after-5%C3%A2-months-of-age-an-italian-multicenter-experience
#1
Maya El Hachem, Francesco Gesualdo, Andrea Diociaiuti, Irene Berti, Nadia Vercellino, Valeria Boccaletti, Iria Neri, Giulio Porcedda, Antonella Greco, Claudia Carnevale, Teresa Oranges, Mario Cutrone, Pietro Dalmonte
BACKGROUND: Despite not being licensed for the treatment of infantile hemangiomas (IH) in infants younger than 5 weeks or older than 5 months, propranolol is often used in these age groups to prevent or to treat potentially severe complications. The objective of the present study was to review the experience of 8 Italian pediatric and dermatologic centers regarding propranolol treatment for IH started before 5 weeks or after 5 months of age. METHODS: We retrospectively reviewed the records of patients followed up for IH, on propranolol treatment started before 5 weeks or after 5 months of age, and collected information on sociodemographic data, treatment indications, IH involution, IH relapse, and treatment side effects...
April 19, 2017: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/28412265/one-stage-supramaximal-full-thickness-wedge-resection-of-vascular-lip-anomalies
#2
Dawn K De Castro, Zhi Yang Ng, Paul W Holzer, Milton Waner, Curtis L Cetrulo, Aaron Fay
PURPOSE: Vascular lip anomalies include infantile hemangiomas, venous malformations, and arteriovenous malformations. Surgical management can be complicated by alterations in horizontal length, vertical height, and lip thickness from the underlying pathology. Additional reconstructive challenges include preservation of oral continence, vermillion definition, and the sublabial sulcus. This report describes a technique of supramaximal single-stage full-thickness wedge resection of these lesions...
March 22, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28388305/treatment-of-vascular-lesions-located-in-the-lip-and-in-the-oral-cavity-with-nd-yag-laser
#3
Julien Totti Bastos, Laila Klotz de Almeida Balassiano, Camila Roos Mariano da Rocha, Bruno Messias Pires de Freitas, Leonardo Gonçalves Bravo, Bruna Souza Felix Bravo
Vascular lesions are common complaints reported in clinics and patients seeking treatment for aesthetic or functional issues. Vascular lesions such as hemangiomas can be found in the oral cavity and some therapeutic modalities can be used in the treatment of these lesions, which the Nd: YAG laser shows good results for easy implementation, fewer complications and satisfactory results. This study describes technique and outcome of a case of hemangioma located on the tongue treated with Nd: YAG laser.
April 7, 2017: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/28303101/psoriasiform-diaper-rash-possibly-induced-by-oral-propranolol-in-an-18-month-old-girl-with-infantile-hemangioma
#4
Raphaëlle Baggio, Claire Le Treut, Laure Darrieux, Amélie Vareliette, Gilles Safa
Propranolol, a nonselective blocker of β-adrenergic receptors, has become the first-line treatment for complicated infantile hemangiomas. Therefore, its use in the pediatric population has expanded in recent years. In adults, β-blockers have been reported to be the most common causative agents for drug-induced psoriasis. In infants treated with propranolol for infantile hemangioma, the onset of psoriasiform diaper rash has not yet been reported. Here, to the best of our knowledge, we report the first case of psoriasiform diaper rash possibly induced by oral propranolol in an 18-month-old girl with no family history of psoriasis...
September 2016: Case Reports in Dermatology
https://www.readbyqxmd.com/read/28301882/infantile-hemangioma-of-the-posterior-fossa-in-a-newborn-early-management-and-long-term-follow-up
#5
Elsa Haine, Annick Sevely, Sergio Boetto, Marie-Bernadette Delisle, Claude Cances
A 21-day-old male infant was admitted with signs of intracranial hypertension. Brain magnetic resonance imaging (MRI) revealed a voluminous mass in the posterior fossa with an intense peripheral enhancement on T1 images with gadolinium. The child was treated secondarily by surgical decompression of the posterior fossa and the lesion was biopsied. The pathological findings indicated infantile hemangioma. Treatment with oral prednisolone was initiated at 3 months, given the lack of tumor involution. Six months after corticotherapy was stopped, repeated MRIs indicated a significant reduction in tumor size and then complete disappearance...
March 16, 2017: Neuropediatrics
https://www.readbyqxmd.com/read/28225076/when-to-stop-propranolol-for-infantile-hemangioma
#6
Lei Chang, Yifei Gu, Zhang Yu, Hanru Ying, Yajing Qiu, Gang Ma, Hui Chen, Yunbo Jin, Xiaoxi Lin
There is no definitive conclusion regarding the optimal timing for terminating propranolol treatment for infantile hemangioma (IH). A total of 149 patients who underwent detailed color Doppler ultrasound examination were included in this study. The characteristics and propranolol treatment of all patients were summarized and analyzed. Patients were divided into two groups according to the lesion regression rate. Among the 149 patients, 38 were assigned to the complete regression group, and 111 were assigned to the partial regression group...
February 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28210449/oral-mucosal-lesions-in-a-chilean-elderly-population-a-retrospective-study-with-a-systematic-review-from-thirteen-countries
#7
César Rivera, Daniel Droguett, María-Jesús Arenas-Márquez
BACKGROUND: The oral examination is an essential part of the multidisciplinary medical care in elderly people. Oral mucosal lesions and normal variations of oral anatomy (OMLs) are very common in this people, but few studies have examined the frequency and prevalence of these conditions worldwide and less in Chile. The aim of this research was to evaluate the frequency of OMLs in a Chilean elderly population. MATERIAL AND METHODS: It was conducted a retrospective study (Talca, Chile)...
February 2017: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/28111788/benign-vascular-lesions-of-the-lips-diagnostic-approach
#8
Priscila L Tobouti, Isabel Olegário, Suzana C O M de Sousa
BACKGROUND: Although not rare, vascular lesions occurring in the lips sometimes poses a difficult in properly diagnosing and handling them. In this study, vascular lesions occurring in the lips were retrieved from an Oral Pathology Service. METHODS: Among 5600 biopsies, 131 cases were found. The following diagnoses were attributed: caliber-persistent artery, infantile hemangioma, vascular malformation, venous lake, thrombus, papillary endothelial hyperplasia and pyogenic granuloma...
January 23, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28064266/infantile-intraosseous-maxillary-hemangioma
#9
Divya Gupta, Ishwar Singh, Kavita Goyal, Parul Sobti
BACKGROUND: Primary osseous hemangiomas of the facial skeleton mimic malignancy. Their location in maxillary sinus, especially in infants is extremely rare. CASE CHARACTERISTICS: 1- month-old full term boy with maxillary swelling. OBSERVATIONS: Biopsy from oral route revealed hemangioma showing vascular channels lined by endothelial cells. Patient improved on oral steroids. MESSAGE: Hemangiomas should be considered as one of the differential diagnosis of unilateral maxillary swelling in infants...
December 15, 2016: Indian Pediatrics
https://www.readbyqxmd.com/read/28043186/oral-propranolol-for-infantile-hemangiomas-a-prospective-study-on-the-role-of-48-hour-holter-monitoring-in-additional-safety-assessment
#10
Jelena Petrovic, Branislav Trifunovic, Goran Vukomanovic, Mirko Topalovic, Goran Trajkovic, Vojislav Parezanović
PURPOSE: Oral propranolol has been recently approved for infantile hemangiomas (IHs), but potential side effects stay a challenge. We sought to make an additional assessment on oral propranolol safety for this indication. MATERIALS AND METHODS: Prospective study included 108 infants consecutively treated for IHs at the University Children's Hospital Tirsova, Belgrade from January 2010 to December 2013. Propranolol was administered orally at a daily dose of 0.5 mg/kg and doubled every 48 hours in the absence of side effects until reaching the maximum dose of 2 mg/kg daily...
January 11, 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/27995117/utility-of-sodium-tetradecyl-sulfate-sclerotherapy-from-benign-oral-vascular-lesion
#11
Bo-Eun Choi, Yongsoo Kim, Dae-Ho Leem, Jin-A Baek, Seung-O Ko
BACKGROUND: Hemangioma and vascular malformation are benign vascular lesions that often occur in cephalic and cervical region. Currently, surgical resection, laser therapy, angiographic embolization, use of steroids, and sclerotherapy are used as treatments. CASE PRESENTATION: This study reports three cases of benign vascular lesions that are remarkably treated by sodium tetradecyl sulfate (STS) injection, of which occurred in oral cavity and around the mouth. Three percent of STS was diluted with 0...
December 2016: Maxillofacial Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/27994889/sclerotherapy-of-intraoral-superficial-hemangioma
#12
Resmije Ademi Abdyli, Yll Abdyli, Feriall Perjuci, Ali Gashi, Zana Agani, Jehona Ahmedi
Hemangioma is the clinical term for a benign vascular neoplasm due to proliferation of the endothelial lining of blood vessels. Their most frequent location is the body skin and oral mucosa. One of the treatment modalities for hemangiomas is intralesional injection of sclerosing agents which cause the damage of blood vessels followed by their obliteration. The objective of the study was to describe the facility of application and evaluate the efficiency of sclerotherapy with aethoxysklerol 1%. Method. The case presented with intraoral submucosal hemangioma of the cheek was treated by intralesional injection of aethoxysklerol 3% diluted in water for injections at a 4 : 1 ratio (0...
2016: Case Reports in Dentistry
https://www.readbyqxmd.com/read/27830673/hemangioma-of-the-oral-and-perioral-region-nd-yag-vs-surgery
#13
Domenico Parisi, Francesco Ciancio, Luigi Cagiano, Monica Rucci, Luigi Annacontini, Aurelio Portincasa
INTRODUCTION: Hemangiomas are very commonly diagnosticated in childhood. The area most affected by this disease is the head and neck. In recent decades, the laser therapy has changed the treatment of hemangiomas through special techniques with advantages in bleeding risk management. MATERIALS AND METHODS: Object of this study is comparing Nd:YAG laser and surgical excision, in terms of aesthetic outcomes, in the treatment of hemangiomas of oral and perioral region...
October 14, 2016: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/27817784/-unexpected-cutaneous-purpura-in-an-infant
#14
Yang-Yang Luo, Zhu Wei, Ying-Hong Zeng, Bin Zhou, Jian-Ping Tang
A two-month-old boy visited the hospital due to unexpected cutaneous purpura and thrombocytopenia for 2 days. The physical examination revealed a purple mass on the back. The soft tissue color Doppler ultrasound showed rich blood signals in the tissue, and the results of bone marrow puncture indicated an increased number of megakaryocytes. After the treatment with hormone and gamma globulin, the platelet count rapidly increased and maintained at a normal level. Meanwhile, the boy was given oral administration of propranolol...
November 2016: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/27747797/therapeutic-effect-of-propranolol-in-mexican-patients-with-infantile-hemangioma
#15
Saul Castaneda, Esbeydy Garcia, Hermelinda De la Cruz, Oscar Ramirez, Samuel Melendez, Jose Sanchez-Palacio
BACKGROUND: Infantile hemangiomas are the most common childhood vascular tumors, occurring in 10 % of children aged less than 1 year. Propranolol, a β-adrenergic blocker mainly indicated for hypertension, has proven effective in treating these types of tumors. OBJECTIVE: To evaluate the efficacy and adverse effects of propranolol in Mexican pediatric patients diagnosed with infantile hemangioma, treated with an extemporaneously compounded solution of propranolol...
March 2016: Drugs—Real World Outcomes
https://www.readbyqxmd.com/read/27688361/safety-of-oral-propranolol-for-the-treatment-of-infantile-hemangioma-a-systematic-review
#16
REVIEW
Christine Léaute-Labrèze, Olivia Boccara, Caroline Degrugillier-Chopinet, Juliette Mazereeuw-Hautier, Sorilla Prey, Geneviève Lebbé, Stéphanie Gautier, Valérie Ortis, Martine Lafon, Agnès Montagne, Alain Delarue, Jean-Jacques Voisard
BACKGROUND AND OBJECTIVES: Given the widespread use of propranolol in infantile hemangioma (IH) it was considered essential to perform a systematic review of its safety. The objectives of this review were to evaluate the safety profile of oral propranolol in the treatment of IH. METHODS: We searched Embase and Medline databases (2007-July 2014) and unpublished data from the manufacturer of Hemangiol/Hemangeol (marketed pediatric formulation of oral propranolol; Pierre Fabre Dermatologie, Lavaur, France)...
October 2016: Pediatrics
https://www.readbyqxmd.com/read/27660822/endothelial-and-circulating-c19mc-micrornas-are-biomarkers-of-infantile-hemangioma
#17
Graham M Strub, Andrew L Kirsh, Mark E Whipple, Winston P Kuo, Rachel B Keller, Raj P Kapur, Mark W Majesky, Jonathan A Perkins
Infantile hemangioma (IH) is the most common vascular tumor of infancy, and it uniquely regresses in response to oral propranolol. MicroRNAs (miRNAs) have emerged as key regulators of vascular development and are dysregulated in many disease processes, but the role of miRNAs in IH growth has not been investigated. We report expression of C19MC, a primate-specific megacluster of miRNAs expressed in placenta with rare expression in postnatal tissues, in glucose transporter 1-expressing (GLUT-1-expressing) IH endothelial cells and in the plasma of children with IH...
September 8, 2016: JCI Insight
https://www.readbyqxmd.com/read/27659092/a-solitary-phlebolith-in-the-buccal-mucosa-report-of-a-rare-entity-and-clinicopathologic-correlation
#18
A Nagaraja, N Govindraj Kumar, B Jambukeshwar Kumar, Raghavendra M Naik, Y Jyoti Sangineedi
Pathological conditions can give rise to calcifications within oral mucosa representing either a local or systemic disturbance. Inflammation, trauma, debris acting as nidus and vascular lesions have been attributed as principal causes for occurrence of calcifications within the oral mucosa. Occurrence of multiple calcified thrombi (phleboliths) is considered pathognomonic for hemangiomas and vascular malformations in the oral and maxillofacial region. Isolated occurrence of phlebolith in oral mucosa though very rare, especially without any underlying vascular lesions, can be diagnostically challenging...
August 1, 2016: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/27609372/-chinese-experts-consensus-on-the-use-of-oral-propranolol-for-treatment-of-infantile-hemangiomas
#19
Jia-Wei Zheng, Xu-Kai Wang, Zhong-Ping Qin, Xin-Dong Fan, Kai Li, Yao-Wu Yang, Ran Huo, Shao-Hua Liu, Ji-Hong Zhao, Xiao-Yong Wang, De-Kai Zhou
Infantile hemangioma (IH) is one of the most common benign vascular tumors in children. A variety of treatment methods have been documented for the management of IH over the past years, including pharmacotherapy via oral administration or injection of corticosteroids, vincristine, alpha interferon and bleomycin; laser therapy, radionuclide therapy, cryotherapy and excisional surgery. The therapeutic efficacy of each treatment modality is variable, while adverse effects or complications are common and sometimes serious...
June 2016: Shanghai Kou Qiang Yi Xue, Shanghai Journal of Stomatology
https://www.readbyqxmd.com/read/27599277/sclerotherapy-and-cryotherapy-in-the-management-of-oral-vascular-lesions-a-series-of-10-cases
#20
Melissa Rodrigues de Araujo, Sanaha Jomaa, Rafael Zancan Mobile, Lucas Caetano Uetanabaro, Allan Fernando Giovanini, Rafaela Scariot, Alexandre Moro
Vascular anomalies such as hemangiomas or vascular malformations can produce negative esthetic effects in the maxillofacial region. These negative effects are the main complaints of patients. The clinical therapeutic efficacy of cryotherapy and sclerotherapy in the treatment of these lesions was evaluated in 10 patients who were clinically diagnosed with vascular lesions. Lesions were submitted to either cryotherapy or sclerotherapy, and follow-up showed that cryotherapy and sclerotherapy both were clinically effective in treating oral vascular lesions...
September 2016: General Dentistry
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