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Oral Herpes

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https://www.readbyqxmd.com/read/28078812/gentiana-scabra-bunge-formula-for-herpes-zoster-biological-actions-of-key-herbs-and-systematic-review-of-efficacy-and-safety
#1
REVIEW
Kaiyi Wang, Meaghan E Coyle, Suzi Mansu, Anthony Lin Zhang, Charlie Changli Xue
This study reviewed the biological action of key herbs and evaluated systematically the efficacy and safety of oral Gentiana formula for herpes zoster (HZ). Experimental studies relevant to HZ were identified in PubMed. Randomized controlled trials using Gentiana formula for HZ were identified from nine English and Chinese databases. The primary outcome was evaluation of pain. Potential risk of bias was assessed. Meta-analysis was conducted using mean difference or risk ratio with 95% confidence intervals. Key herbs Gentiana scabra Bunge, Gentiana triflora Pall, Scutellaria baicalensis Georgi, and Gardenia jasminoides Ellis have shown antiinflammatory actions through inhibition of inflammatory cytokines and pro-inflammatory enzymes...
January 12, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28061417/concurrent-hyphema-and-orbital-apex-syndrome-following-herpes-zoster-ophthalmicus-in-a-middle-aged-lady
#2
Khairuddin Othman, Li Min Evelyn-Tai, Mohd Noor Raja-Azmi, Muhammed Julieana, Ahmad Tajudin Liza-Sharmini, John Tharakan, Alwi Muhd Besari, Embong Zunaina, Ismail Shatriah
INTRODUCTION: Hyphema and orbital apex syndrome occurring concurrently in a patient with herpes zoster ophthalmicus have not been reported previously. We present a case with these unique findings and discuss the pathogenesis of these conditions and their management. PRESENTATION OF CASE: A 59-year-old Malay lady with underlying diabetes mellitus presented with manifestations of zoster ophthalmicus in the left eye. Two weeks later, she developed total hyphema, and complete ophthalmoplegia suggestive of orbital apex syndrome...
December 21, 2016: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28039675/hpv-related-knowledge-among-dentists-and-dental-hygienists
#3
Ellen M Daley, Erika L Thompson, Cheryl A Vamos, Stacey B Griner, Coralia Vazquez-Otero, Alicia L Best, Nolan S Kline, Laura K Merrell
Dental providers, such as dentists and dental hygienists, play an important role in HPV-related oropharyngeal cancer prevention. Dental professional organizations recommend dental providers educate patients about HPV and oral cancers. The objective of this study was to assess HPV knowledge among dental providers. Dentists (n = 36) and dental hygienists (n = 146) attending a professional conference completed a continuing education post-test survey, which included socio-demographics, an HPV knowledge scale, and measure of HPV discussion with patients ("no," "yes," and "yes, but only with some patients")...
December 30, 2016: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
https://www.readbyqxmd.com/read/28009539/sexual-temptation-substance-abuse-no-sex-safe-sex-risky-sex-and-stds
#4
Toto Sutarso, Thomas Li-Ping Tang, Denny R Anerin, Intan W S McCartt, Courtney B Gibson
BACKGROUND: University students' substance abuse and risky sex contribute to sexually transmitted diseases (STDs). PURPOSE: We develop and empirically test a formative theoretical model of sexual temptation involving substance abuse (cigarettes, alcohol, and marijuana), safe sexual behavior (use of condom/barrier for oral and vaginal intercourse), risky sexual behavior (unprotected sex and multiple sexual partners), and STDs: gonorrhea, HIV, and genital herpes. We simultaneously explore these constructs, controlling membership in social groups (fraternity/sorority, varsity athlete, and club sports) and perceived norm of substance abuse...
December 23, 2016: International Journal of Adolescent Medicine and Health
https://www.readbyqxmd.com/read/28008866/antiviral-potential-and-mode-of-action-of-indigofera-heterantha-against-hsv-2-by-targeting-the-early-stages-of-infection
#5
Natasha Kapoor Kaushik, Rupa Guha, Becky M Thomas
BACKGROUND: The development of antivirals against herpes simplex virus 2 (HSV-2) has a major public health importance because of the wide spectrum of associated clinical disease in both immunocompetent and immunocompromised populations. Even with the extensive use of acyclovir, issues such as emergence of drug resistant strains, poor oral bioavailability, and low effectiveness in recurrent infections have highlighted the requirement for alternate therapies. Plants, which are rich in metabolites and active against viruses, are being explored as one such source...
December 23, 2016: Antiviral Therapy
https://www.readbyqxmd.com/read/28002688/ocrelizumab-versus-placebo-in-primary-progressive-multiple-sclerosis
#6
Xavier Montalban, Stephen L Hauser, Ludwig Kappos, Douglas L Arnold, Amit Bar-Or, Giancarlo Comi, Jérôme de Seze, Gavin Giovannoni, Hans-Peter Hartung, Bernhard Hemmer, Fred Lublin, Kottil W Rammohan, Krzysztof Selmaj, Anthony Traboulsee, Annette Sauter, Donna Masterman, Paulo Fontoura, Shibeshih Belachew, Hideki Garren, Nicole Mairon, Peter Chin, Jerry S Wolinsky
Background An evolving understanding of the immunopathogenesis of multiple sclerosis suggests that depleting B cells could be useful for treatment. We studied ocrelizumab, a humanized monoclonal antibody that selectively depletes CD20-expressing B cells, in the primary progressive form of the disease. Methods In this phase 3 trial, we randomly assigned 732 patients with primary progressive multiple sclerosis in a 2:1 ratio to receive intravenous ocrelizumab (600 mg) or placebo every 24 weeks for at least 120 weeks and until a prespecified number of confirmed disability progression events had occurred...
December 21, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27999325/pharmacokinetics-of-the-antiviral-lectin-griffithsin-administered-by-different-routes-indicates-multiple-potential-uses
#7
Christopher Barton, J Calvin Kouokam, Harrell Hurst, Kenneth E Palmer
Griffithsin (GRFT) is a red alga-derived lectin with demonstrated broad spectrum antiviral activity against enveloped viruses, including severe acute respiratory syndrome-Coronavirus (SARS-CoV), Japanese encephalitis virus (JEV), hepatitis C virus (HCV), and herpes simplex virus-2 (HSV-2). However, its pharmacokinetic profile remains largely undefined. Here, Sprague Dawley rats were administered a single dose of GRFT at 10 or 20 mg/kg by intravenous, oral, and subcutaneous routes, respectively, and serum GRFT levels were measured at select time points...
December 17, 2016: Viruses
https://www.readbyqxmd.com/read/27997653/effect-of-pritelivir-compared-with-valacyclovir-on-genital-hsv-2-shedding-in-patients-with-frequent-recurrences-a-randomized-clinical-trial
#8
Anna Wald, Burkhard Timmler, Amalia Magaret, Terri Warren, Stephen Tyring, Christine Johnston, Kenneth Fife, Stacy Selke, Meei-Li Huang, Hans-Peter Stobernack, Holger Zimmermann, Lawrence Corey, Alexander Birkmann, Helga Ruebsamen-Schaeff
Importance: Current therapy of herpes infections relies on nucleoside analogues. Pritelivir is a well-tolerated novel herpes simplex virus (HSV) helicase-primase inhibitor that reduced genital shedding and lesions. Objective: To compare the efficacy of pritelivir with valacyclovir for suppression of genital HSV-2 infection. Design, Setting, and Participants: A phase 2, randomized, double-blind, crossover clinical trial at clinical research centers in 4 US cities (October 2012-July 2013) compared daily oral doses of 100 mg of pritelivir with 500 mg of valacyclovir...
20, 2016: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/27955827/hydroalcoholic-extract-of-brazilian-red-propolis-exerts-protective-effects-on-acetic-acid-induced-ulcerative-colitis-in-a-rodent-model
#9
Gislaine Barbosa Bezerra, Luana de Menezes de Souza, Adailma Santana Dos Santos, Grace Kelly Melo de Almeida, Marília Trindade Santana Souza, Sandra Lauton Santos, Enilton Aparecido Camargo, Bruno Dos Santos Lima, Adriano Antunes de Souza Araújo, Juliana Cordeiro Cardoso, Silvana Vieira Floresta Gomes, Margarete Zanardo Gomes, Ricardo Luiz Cavalcanti de Albuquerque
Ulcerative colitis (UC) is a common intestinal inflammatory disease with an etiology that is not well understood. Although the anti-inflammatory and anti-oxidant effects of the hydroalcoholic extract of Brazilian red propolis (HERP) have been reported in various experimental models, its protective effect in models of UC have not been evaluated. The purpose of this study was to investigate the chemopreventive effect of hydroalcoholic extract of Brazilian red propolis (HERP) in acetic acid-induced colitis (AAIC) using a rodent model...
January 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27921084/the-prevalence-of-herpes-simplex-virus-type-1-and-2-infection-in-iran-a-meta-analysis
#10
REVIEW
Mina Malary, Ghasem Abedi, Zeinab Hamzehgardeshi, Mahdi Afshari, Mahmood Moosazadeh
BACKGROUND: Seroepidemiologic studies indicate a high prevalence of herpes simplex virus (HSV) infection. This infection leads to ophthalmic, dermatologic, oral, neurologic, vaginal and cervical problems. Different studies have been carried out to estimate the HSV seroprevalence in Iran. Combining the results of these studies would be useful for health policy-making. OBJECTIVE: This study aims to estimate the pooled prevalence of HSV infection using meta-analysis...
October 2016: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://www.readbyqxmd.com/read/27904277/herpes-zoster-duplex-unilateralis-two-cases-and-brief-literature-review
#11
Jee Hee Son, Bo Young Chung, Hye One Kim, Hee Jin Cho, Chun Wook Park
Cases involving dermatomal herpes zoster in two or more locations are rare, especially in immunocompetent patients. When two noncontiguous dermatomes are involved, if affected unilaterally, it is called herpes zoster duplex unilateralis; if bilaterally, bilateralis. Here, we report two cases of herpes zoster duplex unilateralis. A 66-year-old man presented with painful erythematous grouped vesicles on his left scalp, forehead, trunk, and back (left [Lt.] V1, Lt. T8). Histologic findings were consistent with herpetic infection...
December 2016: Annals of Dermatology
https://www.readbyqxmd.com/read/27902849/oral-antivirals-for-preventing-recurrent-herpes-simplex-keratitis-in-people-with-corneal-grafts
#12
REVIEW
Uday K Bhatt, M N Abdul Karim, Jeremy I Prydal, Senthil V Maharajan, Usama Fares
BACKGROUND: Ocular herpes is a viral infection of the eye caused by the herpes simplex virus (HSV), a double-stranded DNA virus. Corneal scarring caused by herpes simplex keratitis (HSK) is the leading infectious cause of penetrating corneal graft in high-income countries. Acyclovir is an antiviral drug known to have a protective effect against recurrences in herpetic eye disease. While there are some studies which have evaluated the effects of intervention with oral antiviral in preventing such recurrences in people with corneal grafts, a systematic review of all comparative clinical trials has not been previously undertaken...
November 30, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27885344/drug-induced-hypersensitivity-syndrome-caused-by-carbamazepine-used-for-the-treatment-of-trigeminal-neuralgia
#13
Yuko Ono, Tsuyoshi Shimo, Yoshinori Shirafuji, Toshihisa Hamada, Masanori Masui, Kyoichi Obata, Mayumi Yao, Koji Kishimoto, Akira Sasaki
An 88-year-old man was diagnosed with trigeminal neuralgia, and treatment of carbamazepine 200 mg/day was initiated. About 6 weeks later, the patient developed a skin rash accompanied by fever. He was admitted to hospital and diagnosed with drug-induced hypersensitivity syndrome (DIHS) caused by carbamazepine. Oral carbamazepine treatment was stopped, but blood tests showed acute liver and acute renal failure. Drug-induced lymphocyte stimulation test (DLST) for carbamazepine, human herpes virus-6 (HHV-6) IgG, and CMV-HRP were negative...
2016: Case Reports in Dentistry
https://www.readbyqxmd.com/read/27879550/successful-treatment-of-brachial-plexopathy-due-to-herpes-zoster-infection-with-intravenous-immunoglobulin
#14
Michel Sáenz-Farret, Valeria Sandoval-Rodríguez, Claudia Esther Paz-Navarro, Carlos Zúñiga-Ramírez
OBJECTIVE: The aim of this study was to report the case of a male patient with Parkinson disease who developed brachial plexopathy (BP) due to varicella-zoster virus, which was successfully treated with human immunoglobulin. METHOD: We report the case of a 75-year-old male subject with a diagnosis of Parkinson disease who came to our hospital complaining of pain, skin lesions, and strength loss in his right arm during the past 2 months. Physical examination revealed vesicular rash compatible with varicella-zoster virus lesions...
January 2017: Clinical Neuropharmacology
https://www.readbyqxmd.com/read/27866178/low-level-laser-therapy-a-review-of-its-applications-in-the-management-of-oral-mucosal-disorders
#15
Juliana Cassol Spanemberg, Maria Antonia Zancanaro Figueiredo, Karen Cherubini, Fernanda Gonçalves Salum
Due to its analgesic, anti-inflammatory, and biostimulating effects, low-level laser therapy (LLLT) has been widely used for oral disorders, such as oral lichen planus (OLP), xerostomia, recurrent aphthous stomatitis (RAS), herpes labialis, burning mouth syndrome (BMS), and oral mucositis (OM). The research team for the present study has reviewed the literature on the subject, with an emphasis on the applicability of LLLT in general and of its various clinical protocols for the management of those oral disorders...
November 2016: Alternative Therapies in Health and Medicine
https://www.readbyqxmd.com/read/27853930/a-systematic-review-of-oral-herpetic-viral-infections-in-cancer-patients-commonly-used-outcome-measures-and-interventions
#16
Sharon Elad, Vinisha Ranna, Anura Ariyawardana, Maria Elvira Pizzigatti Correa, Vanessa Tilly, Raj G Nair, Tanya Rouleau, Richard M Logan, Andres Pinto, Veronica Charette, Debbie P Saunders, Siri Beier Jensen
PURPOSE: To review the literature for outcome measures for oral viral infections in cancer patients. A secondary aim was to update the Multinational Association of Supportive Care in Cancer/International Society of Oral Oncology (MASCC/ISOO) clinical practice guidelines for the management of oral viral infections in cancer patients. METHODS: Databases were searched for articles published in the English language, 1981-2013. Studies that met the eligibility criteria were reviewed systematically...
February 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/27845266/psidium-guajava-l-from-ethnobiology-to-scientific-evaluation-elucidating-bioactivity-against-pathogenic-microorganisms
#17
REVIEW
Maria Flaviana B Morais-Braga, Joara Nalyda P Carneiro, Antonio Júdson T Machado, Antonia Thassya L Dos Santos, Débora L Sales, Luciene F Lima, Fernando G Figueredo, Henrique Douglas M Coutinho
ETHNOPHARMACOLOGICAL RELEVANCE: The use of popular plants has guided pharmaceutical research aimed at combating pathogenic microorganisms. Psidium guajava L. is a plant of great versatility and it has been used both as food and as a therapeutic agent. Root, bark, leaves, fruits, flowers and seeds are used for medicinal purposes, especially in infusions and decoctions for oral and topical use. P. guajava is utilized in symptomatology treatment related to organ malfunction and of diseases caused by the action of pathogenic and/or opportunistic microorganisms...
December 24, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27835628/herpes-simplex-virus-type-1-shedding-in-tears-and-nasal-and-oral-mucosa-of-healthy-adults
#18
Meena Ramchandani, Marlene Kong, Elizabeth Tronstein, Stacy Selke, Anna Mikhaylova, Amalia Magaret, Meei-Li Huang, Christine Johnston, Lawrence Corey, Anna Wald
BACKGROUND: Herpes simplex virus type 1 (HSV-1) is prevalent worldwide and causes mucocutaneous infections of the oral area. We aimed to define the frequency and anatomic distribution of HSV-1 reactivation in the facial area in persons with a history of oral herpes. METHODS: Eight immunocompetent HSV-1 seropositive adults were evaluated for shedding of HSV-1 from 12 separate orofacial sites (8 from oral mucosa, 2 from nose, and 2 from conjunctiva) 5 days a week and from the oral cavity 7 days a week for approximately 5 consecutive weeks by a HSV DNA PCR assay...
December 2016: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/27826043/the-interaction-between-human-papillomavirus-and-other-viruses
#19
REVIEW
J T Guidry, R S Scott
The etiological role of human papillomavirus (HPV) in anogenital tract and head and neck cancers is well established. However, only a low percentage of HPV-positive women develop cancer, indicating that HPV is necessary but not sufficient in carcinogenesis. Several biological and environmental cofactors have been implicated in the development of HPV-associated carcinoma that include immune status, hormonal changes, parity, dietary habits, tobacco usage, and co-infection with other sexually transmissible agents...
November 5, 2016: Virus Research
https://www.readbyqxmd.com/read/27815461/antiviral-and-antitumor-activity-of-licorice-root-extracts
#20
Kunihiko Fukuchi, Noriyuki Okudaira, Kazunori Adachi, Reina Odai-Ide, Shigeru Watanabe, Hirokazu Ohno, Masaji Yamamoto, Taisei Kanamoto, Shigemi Terakubo, Hideki Nakashima, Yoshihiro Uesawa, Hajime Kagaya, Hiroshi Sakagami
BACKGROUND: In the search for anti-viral and antitumor substances from natural resources, antiviral and antitumor activities of licorice root extract and purified ingredients were investigated. MATERIALS AND METHODS: Viability of cells was determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide method. Antiviral activity was quantified by the selectivity index, defined as the ratio of the 50% cytotoxic concentration (CC50) to the 50% effective concentration against human immunodeficiency virus (HIV) or herpes simplex virus (HSV)-infected cells (EC50)...
November 2016: In Vivo
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