Cheng Li, Bai-Tong Liu, Yi-Ting Wang, Tian-Jiao Zhang, Xiaochun Zheng, Li Chen, Shaobo Li, Xiaoxian Tian, Dequan Zhang, Yong Wang
The fluorescent flexible sensor for point-of-care quantification of clinical anticoagulant drug, Heparin (Hep), is still an urgent need of breakthrough. In this research, a hyperbranched poly(amido amine) (HPA) was decorated with tetraphenylethene (TPE) and Rhodamine B (RhB), constructing a ratiometric fluorescent sensor (TR-HPA) for Hep. When the sensor was exposed to Hep, the TPE units within the probe skeleton would aggregate, resulting in an increasing fluorescent emission at 483 nm. The 580 nm of fluorescence came from RhB enhance, simultaneously, due to the fluorescence resonance energy transfer...
April 29, 2024: Analytica Chimica Acta