keyword
MENU ▼
Read by QxMD icon Read
search

Medication induced

keyword
https://www.readbyqxmd.com/read/29779126/animal-models-of-chronic-migraine
#1
REVIEW
Tse-Ming Chou, Shih-Pin Chen
PURPOSE OF REVIEW: Chronic migraine (CM) is a recalcitrant subtype of migraine which causes high degrees of disability, poor treatment responses, and frequent recurrences in sufferers. However, the pathophysiological mechanisms underlying the development and chronification of migraine attacks remain incompletely understood. A validated animal model could help to decipher the pathogenic mechanism of the disease, facilitating the development of possible therapeutic strategies for CM. In this review, we aimed to summarize current animal models of CM and discuss the validity of these models...
May 19, 2018: Current Pain and Headache Reports
https://www.readbyqxmd.com/read/29778935/different-levels-of-pro-and-anti-inflammatory-cytokines-in-patients-with-unipolar-and-bipolar-depression
#2
Ruizhi Mao, Chen Zhang, Jun Chen, Guoqing Zhao, Rubai Zhou, Fan Wang, Jingjing Xu, Tao Yang, Yousong Su, Jia Huang, Zhiguo Wu, Lan Cao, Yong Wang, Yingyan Hu, Chengmei Yuan, Zhenghui Yi, Wu Hong, Zuowei Wang, Daihui Peng, Yiru Fang
BACKGROUND: Immune system dysregulation is critical in the physiopathology of major depressive disorder (MDD) and bipolar disorder (BD). However, it is unclear whether both diseases present the same inflammatory patterns during depressive episodes. We explored the differences in pro- and anti-inflammatory cytokines between unipolar and bipolar depression (BDD) and the trajectory of these cytokines after acute-phase treatment. METHODS: Sixty-four MDD patients, 61 BDD patients, and 62 healthy controls (HCs) were enrolled...
April 25, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29778747/novel-peptide-inhibits-inflammation-by-suppressing-of-protease-activated-receptor-2
#3
Bora Kim, Hyun-Soo Kim
We synthesized and investigated the effects of a novel peptide B, RRFSLLRY as a novel PAR-2 antagonist. Peptide B decreased calcium levels in HaCat cells stimulated with trypsin and PAR-2 activator (SLIGKV) and cytokeratin 14 and PCNA was decreased by peptide B. Peptides B also reduced the expression of inflammatory cytokines such as TNF-α and interleukin-6. Significant increase of oxazolone-induced transepidermal water loss (TEWL) was decreased by the addition of peptide B in hairless mice. These findings suggest that the anti-inflammatory effect of peptide B is due to inhibition of PAR-2 signaling...
May 17, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29778249/a-preoperative-cotininury-test-for-abdominoplasty-reduces-peri-operative-complications
#4
F Delaunay, D Coquerel-Beghin, G Magalon, S R Cohen, D Casanova, J Niddam, P-Y Milliez, C Peillon, V Delpierre, I Auquit-Auckbur
BACKGROUND: Smoking induces complications in plastic surgery, in particular wound healing delays. Despite a 4-weeks' abstinence asking before and after surgery, some patients denied or hid their consumption. The aim of this study was to evaluate the effectiveness of a cotininury detection test in terms of improvement in outcomes after an abdominoplasty. MATERIAL AND METHODS: This retrospective cohort study included patients who underwent an abdominoplasty with umbilical transposition and lipoaspiration...
May 16, 2018: Annales de Chirurgie Plastique et Esthétique
https://www.readbyqxmd.com/read/29778130/the-effect-of-increasing-blood-flow-rate-on-severity-of-uremic-pruritus-in-hemodialysis-patients-a-single-clinical-trial
#5
Mansooreh Aliasgharpour, Soheila Zabolypour, Ahmadali Asadinoghabi, Hamid Haghani, Mahboub Lesanpezeshki
BACKGROUND: Although the prevalence of uremic pruritus has decreased compared to the past, the problem still remains as a matter of health and a major challenge of research in medical field, and has no effective treatment at present. This study aimed to investigate the effect of increasing blood flow rate on severity of uremic pruritus in hemodialysis patients in Iran. METHODS: This clinical trial was performed on 60 hemodialysis patients that referred to hospitals affiliated to Tehran University of Medical Sciences and these patients were selected through the convenience method and were treated for four weeks...
June 2018: Journal of the National Medical Association
https://www.readbyqxmd.com/read/29778097/hyperprolactinemia-inducing-antipsychotics-increase-breast-cancer-risk-by-activating-jak-stat5-in-precancerous-lesions
#6
A N Johnston, W Bu, S Hein, S Garcia, L Camacho, L Xue, L Qin, C Nagi, S G Hilsenbeck, J Kapali, K Podsypanina, J Nangia, Y Li
BACKGROUND: Psychiatric medications are widely prescribed in the USA. Many antipsychotics cause serum hyperprolactinemia as an adverse side effect; prolactin-Janus kinase 2 (JAK2)-signal transducer and activator of transcription 5 (STAT5) signaling both induces cell differentiation and suppresses apoptosis. It is controversial whether these antipsychotics increase breast cancer risk. METHODS: We investigated the impact of several antipsychotics on mammary tumorigenesis initiated by retrovirus-mediated delivery of either ErbB2 or HRas or by transgenic expression of Wnt-1...
May 19, 2018: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/29776830/pharmacological-modulation-of-radiation-induced-oral-mucosal-complications
#7
S Bockel, A Vallard, A Lévy, S François, M Bourdis, C Le Gallic, D Riccobono, P Annede, M Drouet, Y Tao, P Blanchard, É Deutsch, N Magné, C Chargari
Radiation-induced mucositis is a common toxicity, especially in patients with head and neck cancers. Despite recent technological advances in radiation therapy, such as intensity-modulated radiotherapy, radiation-induced mucositis is still causing treatment disruptions, negatively affecting patients' long and short term quality of life, and impacting medical resources use with economic consequences. The objective of this article was to review the latest updates in the management of radiation-induced mucositis, with a focus on pharmaceutical strategies for the prevention or treatment of mucositis...
May 15, 2018: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/29776826/recognition-of-sympathetic-crashing-acute-pulmonary-edema-scape-and-use-of-high-dose-nitroglycerin-infusion
#8
Samantha Paone, Leigha Clarkson, Billy Sin, Sheena Punnapuzha
Sympathetic Crashing Acute Pulmonary Edema (SCAPE), or flash pulmonary edema, is the extreme end of the acute pulmonary edema spectrum. A sympathetic surge occurs as a result of decreased systemic perfusion resulting in further increases in afterload, causing the patient to decompensate. Patients can decompensate quickly, therefore patients require rapid interventions. The use of high-dose nitroglycerin (HDN) has been a topic of interest as it is believed to achieve preload and afterload reduction. However, its use continues to be controversial due to concerns of drug induced hypotension, syncope or paresthesia...
May 10, 2018: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29776731/comorbidity-in-illness-induced-posttraumatic-stress-disorder-versus-posttraumatic-stress-disorder-due-to-external-events-in-a-nationally-representative-study
#9
Jordana L Sommer, Natalie Mota, Donald Edmondson, Renée El-Gabalawy
OBJECTIVE: The current study compared physical and mental health characteristics and quality of life of illness-induced posttraumatic stress disorder (PTSD) versus those with PTSD due to external traumatic events in a population-based sample. METHOD: PTSD was assessed with the Alcohol Use Disorder and Associated Disabilities Interview Schedule (AUDADIS-5) using DSM-5 criteria in the 2012-2013 National Epidemiologic Survey on Alcohol and Related Conditions. Participants with past-year PTSD (n = 1779) were categorized into two groups: illness-induced (6...
May 10, 2018: General Hospital Psychiatry
https://www.readbyqxmd.com/read/29776705/-pneumothorax-in-young-cannabis-smokers-a-propos-of-three-cases
#10
M-L Chardon, J-C Dalphin, B Degano
INTRODUCTION: Cannabis consumption is common among adolescents and young adults in France. In addition to its neurological effect, cannabis smoking can induce severe pulmonary emphysema, even in young patients. When a spontaneous pneumothorax occurs in a cannabis smoker, the possibility of a secondary spontaneous pneumothorax should be considered. This may be of importance as management of secondary spontaneous pneumothorax may differ from the well-codified handling of primary spontaneous pneumothorax...
May 15, 2018: Revue des Maladies Respiratoires
https://www.readbyqxmd.com/read/29776390/development-of-a-normal-tissue-complication-probability-ntcp-model-for-radiation-induced-hypothyroidism-in-nasopharyngeal-carcinoma-patients
#11
Ren Luo, Vincent W C Wu, Binghui He, Xiaoying Gao, Zhenxi Xu, Dandan Wang, Zhining Yang, Mei Li, Zhixiong Lin
BACKGROUND: The objectives of this study were to build a normal tissue complication probability (NTCP) model of radiation-induced hypothyroidism (RHT) for nasopharyngeal carcinoma (NPC) patients and to compare it with other four published NTCP models to evaluate its efficacy. METHODS: Medical notes of 174 NPC patients after radiotherapy were reviewed. Biochemical hypothyroidism was defined as an elevated level of serum thyroid-stimulating hormone (TSH) value with a normal or decreased level of serum free thyroxine (fT4) after radiotherapy...
May 18, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29775962/preterm-birth-and-oxidative-stress-effects-of-acute-physical-exercise-and-hypoxia-physiological-responses
#12
Agnès Martin, Camille Faes, Tadej Debevec, Chantal Rytz, Grégoire Millet, Vincent Pialoux
Preterm birth is a global health issue that can induce lifelong medical sequela. Presently, at least one in ten newborns are born prematurely. At birth, preterm newborns exhibit higher levels of oxidative stress (OS) due to the inability to face the oxygen rich environment in which they are born into. Moreover, their immature respiratory, digestive, immune and antioxidant defense systems, as well as the potential numerous medical interventions following a preterm birth, such as oxygen resuscitation, nutrition, phototherapy and blood transfusion further contribute to high levels of OS...
May 1, 2018: Redox Biology
https://www.readbyqxmd.com/read/29775895/ozone-therapy-prevents-the-onset-of-dysplasia-in-hpv16-transgenic-mice-a-pre-clinical-efficacy-and-safety-analysis
#13
C Peirone, V F Mestre, B Medeiros-Fonseca, B Colaço, M J Pires, T Martins, R M Gil da Costa, M J Neuparth, R Medeiros, M M S M Bastos, J A Marques-Magallanes, P A Oliveira
Infection with high-risk human papillomavirus (HPV), most often HPV16, is associated with the development of anogenital and oropharyngeal cancers. Recently, ozone therapy was reported to have considerable efficacy against rabbit VX2 tumors, induced by the cottontail rabbit papillomavirus. The present study aims to determine whether similar results can be obtained in HPV16-transgenic mice, possibly paving the way for new therapeutic options against HPV-induced cancers. HPV16-transgenic and wild-type, female, 20 weeks-old mice were injected intraperitoneally with medical O3 /O2 (80░mL/kg, at O3 50░μg/mL), once a day, for 5 consecutive days...
May 15, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29775803/assisted-reproductive-technologies-and-imprinting-disorders-results-of-a-study-from-a-french-congenital-malformations-registry
#14
Audrey Uk, Sophie Collardeau-Frachon, Quentin Scanvion, Lucas Michon, Emmanuelle Amar
INTRODUCTION: Assisted Reproductive Technologies (ART) is increasingly used to help infertile couples to have children around the world. A number of studies have been published reporting an increased risk of major malformations in children born following ART, especially an increased incidence of epigenetic diseases (ED). This study aimed to assess the incidence of epigenetic diseases with affected imprinting genes in infants or children from pregnancies obtained through IVF/ICSI compared to infants or children from pregnancies obtained spontaneously...
May 15, 2018: European Journal of Medical Genetics
https://www.readbyqxmd.com/read/29774754/effect-of-di-2-ethylhexyl-phthalate-on-the-neuroendocrine-regulation-of-reproduction-in-adult-male-rats-and-its-relationship-to-anxiogenic-behavior-participation-of-gabaergic-system
#15
S Carbone, O J Ponzo, N Gobetto, Y A Samaniego, R Reynoso, J A Moguilevsky, R A Cutrera
The endocrine disruptor di-(2-ethylhexyl) phthalate (DEHP) is used in a variety of consumer products made with polyvinyl chloride and also in the manufacture of medical devices. DEHP disrupts reproductive tract development in an antiandrogenic manner and also may induce neurobehavioral changes. The aim of this study was to investigate the effects of chronic postnatal exposure to DEHP (30 mg/kg body weight/day, orally from birth to day 60) on the neuroendocrine regulation of the gonadal axis and its impact on the anxiety-like behavior in adult male rats, as well as the probable participation of the GABAergic system in these effects...
January 1, 2018: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/29774590/heritage-of-stanislaw-ciechanowski-1869-1945-discoverer-of-pathogenesis-of-prostatic-hyperplasia-passionis-insignia-signis-fulgent-mirificis
#16
Andrzej Wincewicz, Piotr Woltanowski, Stanisław Sulkowski
BACKGROUND: Prostatic enlargement was first correctly recognized as a prostatic hyperplasia by professor of anatomic pathology, Stanisław Ciechanowski (1869-1945) in Cracow on contrary to Parisian urologist Jean Casimir Félix Guyon's concepts of progressing atherosclerosis as a morphological cause of prostatic overgrowth and mechanical insufficiency of lower urinary tract. METHODS: Primary resources were analyzed about Stanisław Ciechanowski mainly from depositories of the Section of Special Collection, Stanisław Konopka Main Medical Library Warsaw and Polish bibliograhy of Estreichers at Jagiellonian University...
May 18, 2018: Prostate
https://www.readbyqxmd.com/read/29774423/diagnosis-and-management-of-gynecomastia-for-urologists
#17
REVIEW
Lee Baumgarten, Ali A Dabaja
PURPOSE OF REVIEW: Our aim is to review the steps of diagnosis and management of gynecomastia with a special focus on treatment of gynecomastia associated with androgen deprivation therapy for prostate cancer. RECENT FINDINGS: Recent studies investigating tamoxifen and radiation therapy for both therapy and prophylaxis of bicalutamide-induced gynecomastia are reviewed. Gynecomastia is a common clinical problem, affecting between one and two thirds of middle-aged men...
May 17, 2018: Current Urology Reports
https://www.readbyqxmd.com/read/29773276/-psychiatric-comorbidities-of-alcohol-dependence
#18
Alain Dervaux, Xavier Laqueille
Psychiatric disorders are common among patients with alcohol dependence. Symptoms of alcohol intoxication or withdrawal need to be disentangled from symptoms of psychiatric disorders. Alcohol dependence could induce psychiatric disorders, in particular depressive disorders and anxiety disorders. Patients with psychiatric disorders may self-medicate with alcohol use. There may be common factors promoting both alcohol dependence and psychiatric disorders: about 40% of patients with alcohol dependence present personality disorders...
May 14, 2018: La Presse Médicale
https://www.readbyqxmd.com/read/29773081/long-term-familial-mediterranean-fever-remission-on-successful-hepatitis-c-virus-treatment-in-a-patient-not-responding-to-colchicine-a-case-report
#19
Manik Gemilyan, Gagik Hakobyan, Susanna Ananyan
BACKGROUND: Familial Mediterranean fever is an autosomal recessive disorder characterized by periodic febrile attacks of aseptic serositis and/or arthritis. The main treatment is colchicine which prevents attacks in the majority of patients except for a group of colchicine-resistant cases. Chronic hepatitis C is a viral infection causing chronic inflammation of liver tissue (hepatitis) which ultimately progresses to fibrosis and liver cirrhosis with a high chance of hepatocellular carcinoma...
May 18, 2018: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29773069/high-altitude-pulmonary-hypertension
#20
Maurizio Bussotti, Giovanni Marchese
The effects of hypoxia on the human organism has been considered doubly fascinating by the scientific community: the knowledge of the discrete mechanisms allowing the acclimatization both at the genetic level or through the cell mediators production in addition to the macroscopic responses of the cardio-circulatory and ventilatory systems to a hypoxic environment has been progressively developed since the last century; moreover granting a safer stay in hypoxic conditions not only for the residents but also for the different cathegories of workers, sportsmen and tourists has been considered a worthy aim of the medical activity...
May 17, 2018: Cardiovascular & Hematological Disorders Drug Targets
keyword
keyword
10781
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"