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https://www.readbyqxmd.com/read/29665152/endothelium-derived-hyperpolarization-mediated-vasodilatation-compensates-nitric-oxide-mediated-endothelial-dysfunction-during-ischemia-in-diabetes-induced-canine-coronary-collateral-microcirculation-in-vivo
#1
Toyotaka Yada, Hiroaki Shimokawa, Hiroyuki Tachibana
OBJECTIVES: It has been previously demonstrated that endothelial caveolin-1 plays crucial roles to produce an endothelium-derived hyperpolarizing factor in mouse mesenteric arteries. We examined whether this mechanism is involved in the endothelium-derived hyperpolarizing-mediated responses to compensate reduced NO-mediated responses in diabetes mellitus during coronary occlusion in dogs in vivo. METHODS: Canine subepicardial collateral coronary small arteries (≥100 μm) and arterioles (<100 μm) were observed by an intravital microscope...
April 17, 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/29663842/mir-7-inhibited-peripheral-nerve-injury-repair-by-affecting-neural-stem-cells-migration-and-proliferation-through-cdc42
#2
Nan Zhou, Shuang Hao, Zongqiang Huang, Weiwei Wang, Penghui Yan, Wei Zhou, Qihang Zhu, Xiaokang Liu
Objective Neural stem cells play an important role in the recovery and regeneration of peripheral nerve injury, and the microRNA-7 (miR-7) regulates differentiation of neural stem cells. This study aimed to explore the role of miR-7 in neural stem cells homing and proliferation and its influence on peripheral nerve injury repair. Methods The mice model of peripheral nerve injury was created by segmental sciatic nerve defect (sciatic nerve injury), and neural stem cells treatment was performed with a gelatin hydrogel conduit containing neural stem cells inserted into the sciatic nerve injury mice...
January 2018: Molecular Pain
https://www.readbyqxmd.com/read/29662959/quarter-century-management-of-chronic-ureteropelvic-junction-obstruction-in-a-solitary-kidney-with-a-ureteral-stent
#3
Garen Abedi, Roshan M Patel, Cyrus Lin, Ralph V Clayman
Background: The ureteral stent provides a conduit for urinary drainage from the kidney to the bladder and is integral to contemporary urologic practice. A ureteral stent is often utilized in acute conditions to prevent or overcome obstruction; however, in nonsurgical patients, because of disease or preference, a ureteral stent may be used as a last resort for long-term management of a stricture in lieu of a nephrostomy tube. This case highlights a patient whose chronic ureteral obstruction has been managed with an indwelling ureteral stent for 25 years; remarkably, stent exchanges are currently required only every 2 years...
2018: Journal of Endourology Case Reports
https://www.readbyqxmd.com/read/29661948/continuing-conundrum-of-multiple-arterial-conduits-for-coronary-artery-bypass-grafting
#4
Mario Gaudino, Stephen E Fremes, David P Taggart
No abstract text is available yet for this article.
April 17, 2018: Circulation
https://www.readbyqxmd.com/read/29660187/increased-flexibility-in-the-use-of-exogenous-lipoic-acid-by-staphylococcus-aureus
#5
Irina Laczkovich, Wei Ping Teoh, Sarah Flury, James P Grayczyk, Azul Zorzoli, Francis Alonzo
Lipoic acid is a cofactor required for intermediary metabolism that is either synthesized de novo or acquired from environmental sources. The bacterial pathogen Staphylococcus aureus encodes enzymes required for de novo biosynthesis, but also encodes two ligases, LplA1 and LplA2, that are sufficient for lipoic acid salvage during infection. S. aureus also encodes two H proteins, GcvH of the glycine cleavage system and the homologous GcvH-L encoded in an operon with LplA2. GcvH is a recognized conduit for lipoyl transfer to α-ketoacid dehydrogenase E2 subunits, while the function of GcvH-L remains unclear...
April 16, 2018: Molecular Microbiology
https://www.readbyqxmd.com/read/29660094/identifying-which-conduits-are-moving-water-in-woody-plants-a-new-hrct-based-method
#6
R Brandon Pratt, Anna L Jacobsen
In vivo imaging methods are useful for examination of plant vascular tissues, particularly in the identification of fluid vs gas-filled conduits; however, these methods may not allow for the simple identification of conductive conduits. Our aim in the present study was to develop a method that would allow for the in vivo identification of conductive conduits. Intact plants and segments of grapevine (Vitis vinifera L.) and intact American chestnut (Castanea dentata (Marshall) Borkh.) saplings were examined. We found that iohexol, a water soluble iodine-rich molecule, was a useful contrast agent...
April 5, 2018: Tree Physiology
https://www.readbyqxmd.com/read/29659782/right-ventricular-outflow-tract-reconstruction-using-a-polytetrafluoroethylene-conduit-in-ross-patients
#7
Ravil Sharifulin, Alexander Bogachev-Prokophiev, Igor Demin, Sergey Zheleznev, Alexey Pivkin, Alexander Afanasyev, Alexander Karaskov
OBJECTIVES: The type of conduit used for right ventricular outflow tract (RVOT) reconstruction during the Ross procedure remains problematic because of the limited availability of pulmonary allografts and the unsatisfactory long-term results associated with the use of xenografts. Polytetrafluoroethylene (PTFE) conduits have been proposed as an alternative. This study evaluated the results of RVOT reconstruction using a PTFE conduit during the Ross procedure. METHODS: Between 2007 and 2015, 28 patients underwent RVOT reconstruction using PTFE conduits...
April 5, 2018: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29659600/reconstruction-of-a-10-mm-long-median-nerve-gap-in-an-ischemic-environment-using-autologous-conduits-with-different-patterns-of-blood-supply-a-comparative-study-in-the-rat
#8
Diogo Casal, Eduarda Mota-Silva, Inês Iria, Sara Alves, Ana Farinho, Cláudia Pen, Nuno Lourenço-Silva, Luís Mascarenhas-Lemos, José Silva-Ferreira, Mário Ferraz-Oliveira, Valentina Vassilenko, Paula Alexandra Videira, João Goyri-O'Neill, Diogo Pais
The aim of this study was to evaluate in the Wistar rat the efficacy of various autologous nerve conduits with various forms of blood supply in reconstructing a 10-mm-long gap in the median nerve (MN) under conditions of local ischemia. A 10-mm-long median nerve defect was created in the right arm. A loose silicone tube was placed around the nerve gap zone, in order to simulate a local ischemic environment. Rats were divided in the following experimental groups (each with 20 rats): the nerve Graft (NG) group, in which the excised MN segment was reattached; the conventional nerve flap (CNF) and the arterialized neurovenous flap (ANVF) groups in which the gap was bridged with homonymous median nerve flaps; the prefabricated nerve flap (PNF) group in which the gap was reconstructed with a fabricated flap created by leaving an arteriovenous fistula in contact with the sciatic nerve for 5 weeks; and the two control groups, Sham and Excision groups...
2018: PloS One
https://www.readbyqxmd.com/read/29657952/surgical-treatment-of-annuloaortic-ectasia-replace-or-repair
#9
Andrea De Martino, Federico Del Re, Stefania Blasi, Michele Celiento, Giacomo Ravenni, Stefano Pratali, Aldo D Milano, Uberto Bortolotti
Background: Patients with annuloaortic ectasia may be surgically treated with modified Bentall or David I valve-sparing procedures. Here, we compared the long-term results of these procedures. Methods: A total of 181 patients with annuloaortic ectasia underwent modified Bentall (102 patients, Group 1) or David I (79 patients, Group 2) procedures from 1994 to 2015. Mean age was 62 ± 11 years in Group 1 and 64 ± 16 years in Group 2. Group 1 patients were in poorer health, with a lower ejection fraction and higher functional class...
October 2017: Aorta (Stamford, Conn.)
https://www.readbyqxmd.com/read/29657092/the-critical-chemical-and-mechanical-regulation-of-folic-acid-on-neural-engineering
#10
Gloria B Kim, Yongjie Chen, Weibo Kang, Jinshan Guo, Russell Payne, Hui Li, Qiong Wei, Julianne Baker, Cheng Dong, Sulin Zhang, Pak Kin Wong, Elias B Rizk, Jiazhi Yan, Jian Yang
The mandate of folic acid supplementation in grained products has reduced the occurrence of neural tube defects by one third in the U.S since its introduction by the Food and Drug Administration in 1998. However, the advantages and possible mechanisms of action of using folic acid for peripheral nerve engineering and neurological diseases still remain largely elusive. Herein, folic acid is described as an inexpensive and multifunctional niche component that modulates behaviors in different cells in the nervous system...
April 3, 2018: Biomaterials
https://www.readbyqxmd.com/read/29656561/advances-in-controlling-differentiation-of-adult-stem-cells-for-peripheral-nerve-regeneration
#11
REVIEW
Metin Uz, Suprem R Das, Shaowei Ding, Donald S Sakaguchi, Jonathan C Claussen, Surya K Mallapragada
Adult stems cells, possessing the ability to grow, migrate, proliferate, and transdifferentiate into various specific phenotypes, constitute a great asset for peripheral nerve regeneration. Adult stem cells' ability to undergo transdifferentiation is sensitive to various cell-to-cell interactions and external stimuli involving interactions with physical, mechanical, and chemical cues within their microenvironment. Various studies have employed different techniques for transdifferentiating adult stem cells from distinct sources into specific lineages (e...
April 14, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29655540/extra-anatomic-suprahepatic-to-innominate-vein-conduit-in-heterotaxy
#12
Erin A Paul, Alejandro J Torres, Anjali Chelliah, Mercedes Martinez, Anne M Ferris, David M Kalfa
No abstract text is available yet for this article.
March 16, 2018: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29652799/combination-kinase-inhibitor-treatment-suppresses-rift-valley-fever-virus-replication
#13
Todd M Bell, Virginia Espina, Lindsay Lundberg, Chelsea Pinkham, Ashwini Brahms, Brian D Carey, Shih-Chao Lin, Bibha Dahal, Caitlin Woodson, Cynthia de la Fuente, Lance A Liotta, Charles L Bailey, Kylene Kehn-Hall
Viruses must parasitize host cell translational machinery in order to make proteins for viral progeny. In this study, we sought to use this signal transduction conduit against them by inhibiting multiple kinases that influence translation. Previous work indicated that several kinases involved in translation, including p70 S6K, p90RSK, ERK, and p38 MAPK, are phosphorylated following Rift Valley fever virus (RVFV) infection. Furthermore, inhibiting p70 S6K through treatment with the FDA approved drug rapamycin prevents RVFV pathogenesis in a mouse model of infection...
April 13, 2018: Viruses
https://www.readbyqxmd.com/read/29652609/an-optimized-collagen-fibrin-blend-engineered-neural-tissue-promotes-peripheral-nerve-repair
#14
Christina Maria Anna Pia Schuh, Adam George Edward Day, Heinz Redl, James Phillips
Tissue engineering approaches in nerve regeneration often aim to improve results by bridging nerve defects with conduits that mimic key features of the nerve autograft. One such approach uses Schwann cell self-alignment and stabilisation within collagen gels to generate engineered neural tissue (EngNT). Here we investigated whether a novel blend of fibrin and collagen could be used to form EngNT, as prior to EngNT design a beneficial effect of fibrin on Schwann cell proliferation was observed. A range of blend formulations was tested in terms of mechanical behavior (gel formation, stabilisation, swelling, tensile strength and stiffness) and lead formulations were assessed in vitro...
March 21, 2018: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/29652421/arterial-hypertension-after-age-65-from-epidemiology-and-pathophysiology-to-therapy-do-we-know-where-we-stand
#15
Jerzy Gąsowski, Karolina Piotrowicz, Franz H Messerli
Arterial hypertension is a prevalent disease with great harming potential. After the age of 55 years the remaining lifetime risk of hypertension amounts to 90%. Despite the constant advances some important issues such as the cut-off blood pressure for the initiation of antihypertensive therapy or the therapeutic goal are debated. In this review, we present - based on the available literature - the current concepts concerning the pathophysiology, epi-demiology and antihypertensive therapy in patients aged 65 years or older...
2018: Kardiologia Polska
https://www.readbyqxmd.com/read/29650982/a-hyphenated-preconcentrator-infrared-hollow-waveguide-sensor-system-for-n-2-o-sensing
#16
João Flavio da Silveira Petruci, Andreas Wilk, Arnaldo Alves Cardoso, Boris Mizaikoff
Following the Kyoto protocol, all signatory countries must provide an annual inventory of greenhouse-gas emission including N2 O. This fact associated with the wide variety of sources for N2 O emissions requires appropriate sensor technologies facilitating in-situ monitoring, compact dimensions, ease of operation, and sufficient sensitivity for addressing such emission scenarios. In this contribution, we therefore describe an innovative portable mid-infrared chemical sensor system for quantifying gaseous N2 O via coupling a substrate-integrated hollow waveguide (iHWG) simultaneously serving as highly miniaturized mid-infrared photon conduit and gas cell to a custom-made preconcentrator...
April 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29649991/interpersonal-communication-regarding-pregnancy-related-services-friends-versus-health-professionals-as-conduits-for-information
#17
Leanne Dougherty, Emily Stammer, Thomas W Valente
BACKGROUND: Social network characteristics influence a wide range of health behaviors but few studies examine the relationship between social network characteristics and pregnancy-related outcomes. METHODS: Using a baseline survey from a behavior change pilot project in the Upper West region of Ghana, we examine four outcomes: (1) early antenatal care, (2) having at least four antenatal care visits, (3) skilled birth attendance, and (4) postpartum care. We collected demographic and network data from 1606 women of reproductive age who had a child in the five years preceding the survey...
April 12, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29649957/tissue-engineered-neo-urinary-conduit-from-decellularized-trachea
#18
Anirudha Anirudhasingh Gmail Com Singh, David Lee, Harrison Jeong, Christine Yu, Jiuru Li, ChenHao Fang, Praveena Sabnekar, Xiaopu Liu, Takahiro Yoshida, Nikolai Sopko, Trinity Bivalacqua
Decellularized tissues have been increasingly popular for constructing scaffolds for tissue engineering applications due to their beneficial biological compositions and mechanical properties. It is therefore natural to consider decellularized trachea for construction of tissue-engineered trachea as well as other tubular organs. A neo-urinary conduit (NUC) is such a tubular organ that works as a passage for urine removal in bladder cancer patients who need a urinary diversion after their diseased bladder is removed...
April 13, 2018: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/29649641/hydrogel-derived-from-porcine-decellularized-nerve-tissue-as-a-promising-biomaterial-for-repairing-peripheral-nerve-defects
#19
Tao Lin, Sheng Liu, Shihao Chen, Shuai Qiu, Zilong Rao, Jianghui Liu, Shuang Zhu, Liwei Yan, Haiquan Mao, Qingtang Zhu, Daping Quan, Xiaolin Liu
Decellularized matrix hydrogels derived from tissues or organs have been used for tissue repair due to their biocompatibility, tunability, and tissue-specific extracellular matrix (ECM) components. However, the preparation of decellularized peripheral nerve matrix hydrogels and their use to repair nerve defects have not been reported. Here, we developed a hydrogel from porcine decellularized nerve matrix (pDNM-G), which was confirmed to have minimal DNA content and retain collagen and glycosaminoglycans content, thereby allowing gelatinization...
April 9, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29644235/endograft-rescue-of-compromised-interposition-aortic-graft-in-an-adult-patient-with-congenital-heart-disease
#20
Jesse W Lee, Kanishka Ratnayaka, Howaida G El-Said, John W Moore
In a 19-year-old male with interrupted aortic arch and complex congenital heart disease, we report percutaneous repair of a compromised aortic conduit. The patient had aortic arch repair in childhood utilizing a 12 mm Hemashield Dacron conduit. CT angiography showed multiple segments of this conduit were dilated to 16 mm suggesting conduit degeneration and failure with pseudoaneurysm formation. We utilized a self-expanding aortic endograft supported by internal placement of bare metal stents to repair the conduit...
March 14, 2018: Global Cardiology Science & Practice
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