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https://www.readbyqxmd.com/read/29222419/probenecid-arrests-the-progression-of-pronounced-clinical-symptoms-in-a-mouse-model-of-multiple-sclerosis
#1
Nadine Hainz, Sandra Wolf, Artjom Beck, Stefan Wagenpfeil, Thomas Tschernig, Carola Meier
While it has been established that Probenecid (PBN) prevents the onset of experimental autoimmune encephalomyelitis (EAE) in mice, it is not clear whether it has any effect on already manifest EAE. The aim of this study was therefore to analyze the therapeutic effect of PBN in pronounced EAE. Mice with manifest clinical symptoms of EAE were either treated with PBN or solvent for 20 days, or they were left untreated. The clinical symptoms were monitored daily. Inflammation, demyelination and oligodendrocyte numbers were determined in the spinal cord...
December 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29221750/secondary-surgical-site-infection-after-coronary-artery-bypass-grafting-a-multi-institutional-prospective-cohort-study
#2
Brian C Gulack, Katherine A Kirkwood, Wei Shi, Peter K Smith, John H Alexander, Sandra G Burks, Annetine C Gelijns, Vinod H Thourani, Daniel Bell, Ann Greenberg, Seth D Goldfarb, Mary Lou Mayer, Michael E Bowdish
OBJECTIVE: To analyze patient risk factors and processes of care associated with secondary surgical-site infection (SSI) after coronary artery bypass grafting (CABG). METHODS: Data were collected prospectively between February and October 2010 for consenting adult patients undergoing CABG with saphenous vein graft (SVG) conduits. Patients who developed a deep or superficial SSI of the leg or groin within 65 days of CABG were compared with those who did not develop a secondary SSI...
December 5, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29220373/can-nerve-regeneration-on-an-artificial-nerve-conduit-be-enhanced-by-ethanol-induced-cervical-sympathetic-ganglion-block
#3
Yoshiki Shionoya, Katsuhisa Sunada, Keiji Shigeno, Akira Nakada, Michitaka Honda, Tatsuo Nakamura
This study aimed to determine whether nerve regeneration by means of an artificial nerve conduit is promoted by ethanol-induced cervical sympathetic ganglion block (CSGB) in a canine model. This study involved two experiments-in part I, the authors examined the effect of CSGB by ethanol injection on long-term blood flow to the orofacial region; part II involved evaluation of the effect of CSGB by ethanol injection on inferior alveolar nerve (IAN) repair using polyglycolic acid-collagen tubes. In part I, seven Beagles were administered left CSGB by injection of 99...
2017: PloS One
https://www.readbyqxmd.com/read/29218499/effect-of-clip3-upregulation-on-astrocyte-proliferation-and-subsequent-glial-scar-formation-in-the-rat-spinal-cord-via-stat3-pathway-after-injury
#4
Xiaoqing Chen, Cheng Chen, Jie Hao, Jiyun Zhang, Feng Zhang
Spinal cord injury (SCI) is a devastating event resulting in neuron degeneration and permanent paralysis through inflammatory cytokine overproduction and glial scar formation. Presently, the endogenous molecular mechanisms coordinating glial scar formation in the injured spinal cord remain elusive. Signal transducer and activator of transcription 3 (STAT3) is a well-known transcription factor particularly involving in cell proliferation and inflammation in the lesion site following SCI. Meanwhile, CAP-Gly domain containing linker protein 3(CLIP3), a vital cytoplasmic protein, has been confirmed to providing an optimal conduit for intracellular signal transduction and interacting with STAT3 with mass spectrometry analysis...
December 7, 2017: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/29217441/impact-of-bmi-on-outcomes-after-mesenteric-revascularization-for-chronic-mesenteric-ischemia
#5
Neel A Mansukhani, Katherine E Hekman, Dustin Y Yoon, Irene B Helenowski, Andrew W Hoel, Heron E Rodriguez, William H Pearce, Mark K Eskandari, Tadaki M Tomita
OBJECTIVE: Historically, patients with chronic mesenteric ischemia (CMI) are underweight with a low body mass index (BMI). However, with the recent obesity epidemic many of these patients now are overweight with a high BMI. We evaluated the impact of BMI on outcomes after mesenteric revascularization for CMI. METHODS: A retrospective chart review of patients undergoing open or endovascular mesenteric revascularization for CMI between January 2000 and June 2015 was performed...
December 4, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29215317/novel-application-and-serial-evaluation-of-tissue-engineered-portal-vein-grafts-in-a-murine-model
#6
Mark W Maxfield, Mitchel R Stacy, Hirotsugu Kurobe, Shuhei Tara, Tai Yi, Muriel A Cleary, Zhen W Zhuang, Manuel I Rodriguez-Davalos, Sukru H Emre, Yasuko Iwakiri, Toshiharu Shinoka, Christopher K Breuer
AIM: Surgical management of pediatric extrahepatic portal vein obstruction requires meso-Rex bypass using autologous or synthetic grafts. Tissue-engineered vascular grafts (TEVGs) provide an alternative, but no validated animal models using portal TEVGs exist. Herein, we preclinically assess TEVGs as portal vein bypass grafts. MATERIALS & METHODS: TEVGs were implanted as portal vein interposition conduits in SCID-beige mice, monitored by ultrasound and micro-computed tomography, and histologically assessed postmortem at 12 months...
December 7, 2017: Regenerative Medicine
https://www.readbyqxmd.com/read/29215277/review-of-the-scientific-understanding-of-radioactive-waste-at-the-u-s-doe-hanford-site
#7
Reid A Peterson, Edgar C Buck, Jaehun Chun, Richard C Daniel, Daniel L Herting, Eugene S Ilton, Gregg J Lumetta, Sue B Clark
This paper reviews the origin and chemical and rheological complexity of radioactive waste at the U.S. Department of Energy Hanford Site. The waste, stored in underground tanks, was generated via three distinct processes over decades of plutonium extraction operations. Although close records were kept of original waste disposition, tank-to-tank transfers and conditions that impede equilibrium complicate our understanding of the chemistry, phase composition, and rheology of the waste. Tank waste slurries comprise particles and aggregates from nano to micron scales, with varying densities, morphologies, heterogeneous compositions, and complicated responses to flow regimes and process conditions...
December 7, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/29213101/modulation-of-the-neisseria-gonorrhoeae-drug-efflux-conduit-mtre
#8
Giulia Tamburrino, Salomé Llabrés, Owen N Vickery, Samantha J Pitt, Ulrich Zachariae
Widespread antibiotic resistance, especially of Gram-negative bacteria, has become a severe concern for human health. Tripartite efflux pumps are one of the major contributors to resistance in Gram-negative pathogens, by efficiently expelling a broad spectrum of antibiotics from the organism. In Neisseria gonorrhoeae, one of the first bacteria for which pan-resistance has been reported, the most expressed efflux complex is MtrCDE. Here we present the electrophysiological characterisation of the outer membrane component MtrE and the membrane fusion protein MtrC, obtained by a combination of planar lipid bilayer recordings and in silico techniques...
December 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29212084/perioperative-outcomes-and-early-survival-in-octogenarians-who-underwent-radical-cystectomy-for-bladder-cancer
#9
Fabio Zattoni, Vito Palumbo, Gianluca Giannarini, Alessandro Crestani, Afrovita Kungulli, Giacomo Novara, Filiberto Zattoni, Vincenzo Ficarra
OBJECTIVE: To evaluate perioperative outcomes and early survival in a series of octogenarians who underwent radical cystectomy (RC) and urinary diversion for bladder cancer. PATIENTS AND METHODS: We retrospectively evaluated the clinical records of 44 patients aged ≥80 years who underwent open RC and urinary diversion at 2 high-volume centers between July 2013 and December 2015. Estimated blood loss (EBL), transfusion rate, and length of hospital stay (LOS) were evaluated...
December 7, 2017: Urologia Internationalis
https://www.readbyqxmd.com/read/29211841/perioperative-benefit-and-outcome-of-thoracic-epidural-in-esophageal-surgery-a-clinical-review
#10
P Feltracco, A Bortolato, S Barbieri, E Michieletto, E Serra, A Ruol, S Merigliano, C Ori
Surgery for esophageal cancer is a highly stressful and painful procedure, and a significant amount of analgesics may be required to eliminate perioperative pain and blunt the stress response to surgery. Proper management of postoperative pain has invariably been shown to reduce the incidence of postoperative complications and accelerate recovery. Neuraxial analgesic techniques after major thoracic and upper abdominal surgery have long been established to reduce respiratory, cardiovascular, metabolic, inflammatory, and neurohormonal complications...
December 2, 2017: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/29211359/continent-catheterizable-conduits-in-pediatric-urology-one-center-experience
#11
Paweł Kroll, Ewa Gajewska, Jacek Zachwieja, Danuta Ostalska-Nowicka, Maciej Micker, Andrzej Jankowski
BACKGROUND: Clean intermittent catheterization (CIC) is a standard treatment for patients who are unable to empty the bladder. In the absence of the urethra or if catheterization through the urethra is problematic, a continent vesicostomy is used as a catheterizable conduit. The Malone procedure is an established treatment option for children with neurogenic constipation and fecal incontinence. OBJECTIVES: The aim of the study was to report the authors' experience with continent catheterizable conduits (CCCs) in children, to review the results and to determine the efficacy of the technique, with an emphasis on continence and the need for revision...
October 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29210019/pathology-of-stent-implantation-in-internal-mammary-artery
#12
Hiroyoshi Mori, Ryan Braumann, Sho Torii, Hiroyuki Jinnouchi, Emanuel Harari, Robert Kutys, Maria Romero, Renu Virmani, Aloke Finn
The internal mammary artery (IMA) is the most durable conduit for bypassing the left anterior descending (LAD) coronary artery in patients undergoing coronary artery bypass graft surgery (CABG). However, little is known about how the IMA reacts histologically to stent implantation. From CVPath stent registry (1048 lesions, 614 cases), we obtained 4 stent lesions (2 bare metal stents, 2 drug-eluting stents) involving IMA grafts. The mean age of our patients was 63 years and the duration of stent implantation in the IMA ranged from 5 days to 5 years...
December 5, 2017: Cardiovascular Intervention and Therapeutics
https://www.readbyqxmd.com/read/29208426/5-azacytidine-engages-an-ire1%C3%AE-egfr-erk1-2-signaling-pathway-that-stabilizes-the-ldl-receptor-mrna
#13
Nourhen Mnasri, Maya Mamarbachi, Bruce G Allen, Gaétan Mayer
Hepatic low-density lipoprotein receptor (LDLR) is the primary conduit for the clearance of plasma LDL-cholesterol and increasing its expression represents a central goal for treating cardiovascular disease. However, LDLR mRNA is unstable and undergoes rapid turnover mainly due to the three AU-rich elements (ARE) in its proximal 3'-untranslated region (3'-UTR). Herein, our data revealed that 5-azacytidine (5-AzaC), an antimetabolite used in the treatment of myelodysplastic syndrome, stabilizes the LDLR mRNA through a previously unrecognized signaling pathway resulting in a strong increase of its protein level in human hepatocytes in culture...
December 2, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29208270/nano-fibrous-and-ladder-like-multi-channel-nerve-conduits-degradation-and-modification-by-gelatin
#14
Sheng Liu, Xiumin Sun, Tao Wang, Shihao Chen, Chen-Guang Zeng, Gaoyi Xie, Qingtang Zhu, Xiaolin Liu, Daping Quan
We recently fabricated multi-channel PLLA nerve conduits (NCs, conduits diameter: ~3mm, channels diameter: ~200μm) with nano-fibrous microstructure (NNCs) and ladder-like microstructure (LNCs), and found the nanofibers in the NNCs promote differentiation of nerve stem cells (NSCs) into neurons. In the present study, we evaluated the degradation profile of NNCs and LNCs, and observed that NNCs degraded too fast to implant. To delay the degradation and retain the nano-scale effect of NNCs, we used gelatin to wrap (2% w/v gelatin) or embed (8% w/v gelatin) NNCs and LNCs via vacuum infusion and chemical cross-linking with genipin...
February 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/29206677/benchmarking-complications-associated-with-esophagectomy
#15
Donald E Low, Madhan Kumar Kuppusamy, Derek Alderson, Ivan Cecconello, Andrew C Chang, Gail Darling, Andrew Davies, Xavier Benoit D'Journo, Suzanne S Gisbertz, S Michael Griffin, Richard Hardwick, Arnulf Hoelscher, Wayne Hofstetter, Blair Jobe, Yuko Kitagawa, Simon Law, Christophe Mariette, Nick Maynard, Christopher R Morse, Philippe Nafteux, Manuel Pera, C S Pramesh, Sonia Puig, John V Reynolds, Wolfgang Schroeder, Mark Smithers, B P L Wijnhoven
OBJECTIVE: Utilizing a standardized dataset with specific definitions to prospectively collect international data to provide a benchmark for complications and outcomes associated with esophagectomy. SUMMARY OF BACKGROUND DATA: Outcome reporting in oncologic surgery has suffered from the lack of a standardized system for reporting operative results particularly complications. This is particularly the case for esophagectomy affecting the accuracy and relevance of international outcome assessments, clinical trial results, and quality improvement projects...
December 4, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/29205762/crohn-s-disease-involving-ileal-conduit-a-case-report
#16
Soumya Prabhakaran, Andrew Finlayson, Paul D Anderson, Ian P Hayes
No abstract text is available yet for this article.
December 3, 2017: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/29205510/correction-of-cortriatriatum-sinister-with-classical-raghib-s-complex-using-an-extracardiac-conduit
#17
Koray Ak, Anar Hamidov, Ciğdem Ileri, Kursat Tigen, Selim Isbir, Sinan Arsan
We present a 32-year-old patient with cortriatriatum sinister with Raghib's complex (a left persistent superior vena cava draining into the left atrium with an absent coronary sinus and an atrial septal defect [ASD]) who underwent successful surgical correction with excision of the cortriatriatum, closure of the ASD, and establishing the drainage of the persistent left superior vena cava to the right atrium via interposition of an extracardiac 13-mm ringed polytetrafluoroethylene conduit.
November 2017: Journal of Cardiac Surgery
https://www.readbyqxmd.com/read/29203767/crystal-plasticity-as-an-indicator-of-the-viscous-brittle-transition-in-magmas
#18
J E Kendrick, Y Lavallée, E Mariani, D B Dingwell, J Wheeler, N R Varley
Understanding the flow of multi-phase (melt, crystals and bubbles) magmas is of great importance for interpreting eruption dynamics. Here we report the first observation of crystal plasticity, identified using electron backscatter diffraction, in plagioclase in andesite dome lavas from Volcán de Colima, Mexico. The same lavas, deformed experimentally at volcanic conduit temperature and load conditions, exhibit a further, systematic plastic response in the crystalline fraction, observable as a lattice misorientation...
December 4, 2017: Nature Communications
https://www.readbyqxmd.com/read/29203037/near-infrared-perfusion-assessment-of-gastric-conduit-during-minimally-invasive-ivor-lewis-esophagectomy
#19
Brian G A Dalton, Abubaker A Ali, Marie Crandall, Ziad T Awad
INTRODUCTION: Anastomotic leak and conduit necrosis are devastating complications following Ivor Lewis esophagectomy. Near infrared imaging (NIR) using IndoCyanine Green allows for real time tissue perfusion assessment which may reduce anastomotic leak during minimally invasive Ivor Lewis esophagectomy (MIE). METHODS: Forty consecutive MIE were performed by a single surgeon at a tertiary referral center. The first 20 were assessed for gastric conduit perfusion by clinical criteria (Group 1)...
November 28, 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/29202351/psoas-abscess-masquerading-as-a-prosthetic-hip-infection-a-case-report
#20
Muhammad Atif, Azeem Tariq Malik, Shahryar Noordin
INTRODUCTION: Psoas abscess is an unusual condition and is defined as a collection of pus in the iliopsoas compartment. Due to the unique anatomy of psoas muscle it forms a conduit for spread of infection from upper part of body to hip joint in neglected cases. CASE PRESENTATION: A 67year old lady presented with left groin pain for three weeks. She underwent an uncemented unipolar hemiarthoplasty eight years back. Currently, she developed fever and was unable to do any active left hip range of motion...
December 1, 2017: International Journal of Surgery Case Reports
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