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Patricio C Gargollo, Candace Granberg, Edward Gong, Duong Tu, Benjamin Whittam, Daniel Dajusta
PURPOSE: We describe our experience with robot assisted complex lower urinary tract reconstruction (CUTR) in patients with previous open abdominal surgery (PAS). MATERIALS AND METHODS: Patients with any PAS undergoing robot assisted CUTR were included. CUTR was defined as bladder neck reconstruction (BNR) or continent catheterizable conduits (CCC) or both, redo surgery at the bladder neck for persistent incontinence, or any of the above with an antegrade enema channel creation (MACE)...
June 12, 2018: Journal of Urology
Ingrid M Ganske, Joseph M Firriolo, Laura C Nuzzi, Oren Ganor, Thomas E Hamilton, C Jason Smithers, Russell W Jennings, Joseph Upton, Brian I Labow, Amir H Taghinia
BACKGROUND: A variety of surgical techniques exist to manage long-gap esophageal atresia (LGEA), including gastric pull-up (GPU), colonic interposition (CI), jejunal interposition (JI), and distraction lengthening. Salvage reconstruction for late failure of any conduit type is a complex surgical problem fraught with technical difficulty and significant risk. Jejunal interposition can be used as a salvage procedure in the management of LGEA. However, the opposing requirements of conduit length and adequate perfusion make the procedure technically challenging...
June 13, 2018: Annals of Plastic Surgery
Matthew I Jones, Shakeel A Qureshi
Surgical repair of tetralogy of Fallot (ToF) in childhood is associated with generally good outcomes, and almost all children can be expected to survive until adulthood. However, significant pulmonary regurgitation leading to progressive right ventricular dilatation is common in teenagers or young adults because of the nature of the surgical intervention. In patients whose repair included placement of a right ventricle to pulmonary artery conduit, it has been possible to place a stented valve within the conduit to treat this...
2018: F1000Research
Kiran K Andra, Savanna Dorsey, Catherine Royer, Anant K Menon
Most members of the TransMEMbrane protein 16 (TMEM16) family are Ca2+ -regulated scramblases that facilitate the bidirectional movement of phospholipids across membranes necessary for diverse physiological processes. The nhTMEM16 scramblase (from the fungus Nectria haematococca ) is a homodimer with a large cytoplasmic region and a hydrophilic, membrane-exposed groove in each monomer. The groove provides the transbilayer conduit for lipids, but the mechanism by which Ca2+ regulates it is not clear. Because fusion of large protein tags at either the N or C terminus abolishes nhTMEM16 activity, we hypothesized that its cytoplasmic portion containing both termini may regulate lipid translocation via a Ca2+ -dependent conformational change...
June 14, 2018: Journal of Biological Chemistry
Stella Baliou, Maria Adamaki, Anthony M Kyriakopoulos, Demetrios A Spandidos, Michalis Panagiotidis, Ioannis Christodoulou, Vassilis Zoumpourlis
One of the fundamental discoveries in the field of biology is the ability to modulate the genome and to monitor the functional outputs derived from genomic alterations. In order to unravel new therapeutic options, scientists had initially focused on inducing genetic alterations in primary cells, in established cancer cell lines and mouse models using either RNA interference or cDNA overexpression or various programmable nucleases [zinc finger nucleases (ZNF), transcription activator-like effector nucleases (TALEN)]...
June 6, 2018: International Journal of Oncology
John Schembri, Jonathan Bury, Lesley Hunt, Stuart Riley
BACKGROUND: Adenocarcinomas can arise in a variety of circumstances in which intestinal segments have been used for urinary diversions. Whereas ureterosigmoidostomy is the oldest and simplest form of continent urinary diversion it also seems to be the most dangerous in this regard. Herein we present a case of colonic neoplasia complicating a non-functioning ureterosigmoidostomy after 55 years; the longest latent period documented to date. CASE PRESENTATION: A 56-year-old lady born with congenital bladder exystrophy and who had a functional ileal conduit presented to us with a 6 month history of change in bowel habit and rectal bleeding...
June 14, 2018: BMC Gastroenterology
A J Macnab, R Mukisa
There are calls for innovation in health promotion and for current issues to be presented in new and exciting ways; in addition to creating engaging messages, novel ways to deliver health messaging are needed, especially where youth are the key target audience. When pupils in WHO Health Promoting Schools were asked what health messages would resonate with them, they also identified celebrities as the 'messengers' they would be particularly likely to listen to. Expanding on these discussions, the pupils quoted celebrity-recorded music videos containing health and lifestyle messaging as an example of where they had learned from celebrities...
June 11, 2018: Health Promotion International
Marcin Zadworny, Louise H Comas, David M Eissenstat
Background and Aims: Understanding root traits and their trade-off with other plant processes is important for understanding plant functioning in natural ecosystems as well as agricultural systems. The aim of the present study was to determine the relationship between root morphology and the hydraulic characteristics of several orders of fine roots (<2 mm) for species differing in shade tolerance (low, moderate and high). Methods: The morphological, anatomical and hydraulic traits across five distal root orders were measured in species with different levels of shade tolerance and life history strategies...
April 20, 2018: Annals of Botany
Gregory A Joice, Meera R Chappidi, Hiten D Patel, Max Kates, Nikolai A Sopko, C J Stimson, Phillip M Pierorazio, Trinity J Bivalacqua
OBJECTIVES: To investigate the impact of continent urinary diversion on readmissions and hospital costs in a nationally representative sample of radical cystectomies (RC) performed in the United States. MATERIALS & METHODS: The 2010-2014 Nationwide Readmissions Database was queried for patients with a diagnosis of bladder cancer who underwent RC. We identified patients undergoing continent (neobladder or continent cutaneous reservoir) or incontinent (ileal conduit) diversions...
June 13, 2018: BJU International
Edwin J Aslim, Min Hoe Chew, Ghee Kheng Chew, Lui Shiong Lee
BACKGROUND: Pelvic exenteration (PE) for locally advanced pelvic malignancy requires a multi-disciplinary approach and is associated with significant morbidity. Urinary reconstruction forms a major component of this procedure. The aim of the study is to review the urological outcomes following PE in a newly established pelvic oncology unit, to compare with those following radical cystectomy (RC) for bladder cancer. METHODS: Patients were identified from prospectively maintained PE and bladder cancer databases, inclusive of all cases performed between January 2012 and December 2016...
June 12, 2018: ANZ Journal of Surgery
Yuchao Wang, Kefeng Li, Peng Li, Jimin Sun, Ling Ye, Yaxin Dai, An Tang, Jianmin Jiang, Can Chen, Zhendong Tong, Jianbo Yan
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging disease caused by the SFTS virus (SFTSV) from Bunyaviridae. Since the virus firstly isolated in 2009, it has been widely spread in China with increasing cases year by year. Although the exploration of the disease has been extensively researched in past years, there is still no effective measures to suppress the epidemic situation. Currently, we report a pilot study concerning the comprehensive measures, which included health education and risk communication, weeds removal, livestock management and ticks control, to prevent this emerging disease in an endemic region of China...
June 9, 2018: International Journal of Infectious Diseases: IJID
Alistair Royse, Zulfayandi Pawanis, David Canty, Jared Ou-Young, David Eccleston, Andrew Ajani, Christopher M Reid, Rinaldo Bellomo, Colin Royse
OBJECTIVES: Saphenous vein graft (SVG) remains the predominant conduit used in coronary surgery. The internal mammary artery has higher later term patency and confers superior survival. Current debate focuses on the increased use of arterial conduits rather than eradication of venous conduits. METHODS: Patient data extracted from the Australian and New Zealand Society of Cardiothoracic Surgeons database from 2001-2013 were linked to the national death registry held by the Australian Institute of Health and Welfare for all-cause mortality with censor date 7 October 2014...
June 8, 2018: European Journal of Cardio-thoracic Surgery
Bradley S Fleenor, An Ouyang, T Dylan Olver, Jessica A Hiemstra, Melissa S Cobb, Gianmaria Minervini, Craig A Emter
Increased peripheral conduit artery stiffness has been shown in patients with heart failure (HF) with preserved ejection fraction. However, it is unknown whether this phenomenon extends to the coronary vasculature. HF with preserved ejection fraction may be driven, in part, by coronary inflammation, and inhibition of the enzyme DPP-4 (dipeptidyl-peptidase 4) reduces inflammation and oxidative stress. The purpose of this study was to determine the effect of saxagliptin-a DPP-4 inhibitor-on coronary stiffness in aortic-banded mini swine...
June 11, 2018: Hypertension
Anna L R Xavier, Natalie Linea Hauglund, Stephanie von Holstein-Rathlou, Qianliang Li, Simon Sanggaard, Nanhong Lou, Iben Lundgaard, Maiken Nedergaard
Cisterna magna cannulation (CMc) is a straightforward procedure that enables direct access to the cerebrospinal fluid (CSF) without operative damage to the skull or the brain parenchyma. In anesthetized rodents, the exposure of the dura mater by blunt dissection of the neck muscles allows the insertion of a cannula into the cisterna magna (CM). The cannula, composed either by a fine beveled needle or borosilicate capillary, is attached via a polyethylene (PE) tube to a syringe. Using a syringe pump, molecules can then be injected at controlled rates directly into the CM, which is continuous with the subarachnoid space...
May 23, 2018: Journal of Visualized Experiments: JoVE
Tony Lu, Stephanie G Yi, Jean Bismuth, Richard J Knight, A Osama Gaber, Carlos F Bechara
Renal transplantation remains the definitive treatment for end stage renal disease (ESRD). The shorter renal vein in right donor nephrectomies is associated with higher incidence of technical failure. We present here our experience with autologous internal jugular vein (IJV) conduits to facilitate living-donor transplants. Six patients underwent right, living-donor kidney transplant with simultaneous IJV harvest over a one year period. All had bilateral jugular duplex scans preoperatively, and were placed on aspirin 81 mg postoperatively...
June 11, 2018: Clinical Transplantation
Hideki Miyachi, James W Reinhardt, Satoru Otsuru, Shuhei Tara, Hidetaka Nakayama, Tai Yi, Yong-Ung Lee, Shinka Miyamoto, Toshihiro Shoji, Tadahisa Sugiura, Christopher K Breuer, Toshiharu Shinoka
BACKGROUND: Acute thrombosis is a crucial cause of bioresorbable vascular graft (BVG) failure. Bone marrow-derived mononuclear cell (BM-MNC)-seeded BVGs demonstrated high graft patency, however, the effect of seeded BM-MNCs against thrombosis remains to be elucidated. Thus, we evaluated an antithrombotic effect of BM-MNC-seeding and utilized platelet-depletion mouse models to evaluate the contribution of platelets to acute thrombosis of BVGs. METHODS AND RESULTS: BVGs were composed of poly(glycolic acid) mesh sealed with poly(l-lactideco-ε-caprolactone)...
September 1, 2018: International Journal of Cardiology
Anub G John, Glenn A Hirsch, Marcus F Stoddard
OBJECTIVES: This study assessed if frequent premature atrial contractions (PACs) were associated with decreased left atrial (LA) strain and adverse remodeling. BACKGROUND: Left atrial dysfunction and enlargement increases risk of stroke. If frequent PACs cause LA dysfunction and remodeling, PAC suppressive therapy may be beneficial. METHODS: Inclusion criteria were age ≥18 years and sinus rhythm. Exclusion criteria were atrial fibrillation or any etiology for LA enlargement...
June 10, 2018: Echocardiography
Mohammad Abualhin, Alessia Sonetto, Gianluca Faggioli, Michele Mirelli, Antonio Freyrie, Enrico Gallitto, Andrea Stella, Mauro Gargiulo
INTRODUCTION: The aim of the study was to evaluate the outcomes of Duplex Ultrasonoghraphy(DUS) guided autologous vein bypass to paramalleolar (distal third of tibial arteries and peroneal artery) and inframalleolar arteries (dorsalis pedis, common plantar, medial and lateral plantar arteries) in patients with critical limb ischemia (CLI) and extensive tibial arteries disease TASC D. METHODS: Between January 2007 and October 2016, all paramalleolar or inframalleolar bypasses performed in patients with CLI, planned only on the basis of DUS were collected and analyzed retrospectively...
June 7, 2018: Annals of Vascular Surgery
William A Lackington, Rosanne M Raftery, Fergal J O'Brien
Despite the success of tissue engineered nerve guidance conduits (NGCs) for the treatment of small peripheral nerve injuries, autografts remain the clinical gold standard for larger injuries. The delivery of neurotrophic factors from conduits might enhance repair for more effective treatment of larger injuries but the efficacy of such systems is dependent on a safe, effective platform for controlled and localised therapeutic delivery. Gene therapy might offer an innovative approach to control the timing, release and level of neurotrophic factor production by directing cells to transiently sustain therapeutic protein production in situ...
June 7, 2018: Acta Biomaterialia
Karl H Schneider, Marjan Enayati, Christian Grasl, Ingrid Walter, Lubos Budinsky, Gabriel Zebic, Christoph Kaun, Anja Wagner, Klaus Kratochwill, Heinz Redl, Andreas H Teuschl, Bruno K Podesser, Helga Bergmeister
Small diameter vascular grafts from human placenta, decellularized with either Triton X-100 (Triton) or SDS and crosslinked with heparin were constructed and characterized. Graft biochemical properties, residual DNA, and protein composition were evaluated to compare the effect of the two detergents on graft matrix composition and structural alterations. Biocompatibility was tested in vitro by culturing the grafts with primary human macrophages and in vivo by subcutaneous implantation of graft conduits (n = 7 per group) into the flanks of nude rats...
May 29, 2018: Biomaterials
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