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https://www.readbyqxmd.com/read/29054972/endothelial-function-is-impaired-in-the-cutaneous-microcirculation-of-adults-with-psoriasis-through-reductions-in-nitric-oxide-dependent-vasodilation
#1
Billie K Alba, Jody L Greaney, Sara B Ferguson, Lacy M Alexander
Psoriasis is an independent risk factor for cardiovascular disease, however the underlying mechanisms are not fully understood. Deficits in conduit arterial function are evident in psoriatics, but potential impairments in microcirculatory endothelial function remain unclear. We hypothesized that cutaneous microvascular dysfunction would be detectable in otherwise healthy psoriatics. Two intradermal microdialysis fibers were placed in (non-lesional) forearm skin of 9 patients with moderate plaque psoriasis (3M, 6F; 39±5 yr; 16±2 %BSA) and 9 non-psoriatic controls (3M, 6F; 38±5 yr) for local delivery of 1) lactated Ringer's (control) and 2) 10mM L-ascorbate (non-specific antioxidant)...
October 20, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29053076/protective-effect-of-biodegradable-nerve-conduit-against-peripheral-nerve-adhesion-after-neurolysis
#2
Kosuke Shintani, Takuya Uemura, Kiyohito Takamatsu, Takuya Yokoi, Ema Onode, Mitsuhiro Okada, Hiroaki Nakamura
OBJECTIVE Peripheral nerve adhesion caused by extraneural and intraneural scar formation after neurolysis leads to nerve dysfunction. The authors previously developed a novel very flexible biodegradable nerve conduit composed of poly(L-lactide) and poly(ε-caprolactone) for use in peripheral nerve regeneration. In the present study, they investigated the effect of protective nerve wrapping on preventing adhesion in a rat sciatic nerve adhesion model. METHODS Rat sciatic nerves were randomly assigned to one of the following four groups: a no-adhesion group, which involved neurolysis alone without an adhesion procedure; an adhesion group, in which the adhesion procedure was performed after neurolysis, but no treatment was subsequently administered; a nerve wrap group, in which the adhesion procedure was performed after neurolysis and protective nerve wrapping was then performed with the nerve conduit; and a hyaluronic acid (HA) group, in which the adhesion procedure was performed after neurolysis and nerve wrapping was then performed with a 1% sodium HA viscous solution...
October 20, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29051388/a-conduit-to-metastasis-circulating-tumor-cell-biology
#3
REVIEW
Douglas S Micalizzi, Shyamala Maheswaran, Daniel A Haber
Advances in the enrichment and analysis of rare cells from the bloodstream have allowed for detection and characterization of circulating tumor cells (CTCs) from patients with cancer. The analysis of CTCs has provided significant insight into the metastatic process. Studies on the biology of CTCs have begun to elucidate the molecular mechanisms of CTC generation, intravasation, survival, interactions with components of the blood, extravasation, and colonization of distant organs. Additionally, the study of CTCs has exposed dramatic intrapatient and interpatient heterogeneity and their evolution over time...
September 15, 2017: Genes & Development
https://www.readbyqxmd.com/read/29051066/study-of-the-cys-his-bridge-electron-transfer-pathway-in-a-copper-containing-nitrite-reductase-by-site-directed-mutagenesis-spectroscopic-and-computational-methods
#4
Julio C Cristaldi, María C Gómez, Pablo J González, Felix M Ferroni, Sergio Dalosto, Alberto C Rizzi, María G Rivas, Carlos D Brondino
The Cys-His bridge as electron transfer conduit in the enzymatic catalysis of nitrite to nitric oxide by nitrite reductase from Sinorhizobium meliloti 2011 (SmNir) was evaluated by site-directed mutagenesis, steady state kinetic studies, UV-vis and EPR spectroscopic measurements as well as computational calculations. The kinetic, structural and spectroscopic properties of the His171Asp (H171D) and Cys172Asp (C172D) SmNir variants were compared with the wild type enzyme. Molecular properties of H171D and C172D indicate that these point mutations have not visible effects on the quaternary structure of SmNir...
October 16, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29050973/a-simulation-model-for-methane-emissions-from-landfills-with-interaction-of-vegetation-and-cover-soil
#5
Rongxing Bian, Danhui Xin, Xiaoli Chai
Global climate change and ecological problems brought about by greenhouse gas effect have become a severe threat to humanity in the 21st century. Vegetation plays an important role in methane (CH4) transport, oxidation and emissions from municipal solid waste (MSW) landfills as it modifies the physical and chemical properties of the cover soil, and transports CH4 to the atmosphere directly via their conduits, which are mainly aerenchymatous structures. In this study, a novel 2-D simulation CH4 emission model was established, based on an interactive mechanism of cover soil and vegetation, to model CH4 transport, oxidation and emissions in landfill cover soil...
October 16, 2017: Waste Management
https://www.readbyqxmd.com/read/29050816/applicability-of-handmade-expanded-polytetrafluoroethylene-trileaflet-valved-conduits-for-pulmonary-valve-reconstruction-an-ex%C3%A2-vivo-and-in%C3%A2-vivo-study
#6
Chung-Dann Kan, Jieh-Neng Wang, Wei-Ling Chen, Pong-Jeu Lu, Ming-Yao Chan, Chia-Hung Lin, Wan-Chin Hsieh
OBJECTIVE: The handmade expanded polytetrafluoroethylene (ePTFE) trileaflet-valved conduit could potentially be used as a substitute pulmonary valve replacement material, especially in children. The current study investigated (1) the function of the ePTFE trileaflet-valved conduits in an ex vivo experimental system and (2) the short-term performance of the conduit in a porcine model to verify its clinical applicability. METHODS: The competency of the ePTFE trileaflet-valved conduits was estimated through ex vivo (using a pulmonary mock circulation loop) and in vivo (in a porcine model with a damaged pulmonary valve) experiments...
September 20, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29050815/right-ventricular-outflow-tract-reintervention-after-primary-tetralogy-of-fallot-repair-in-neonates-and-young-infants
#7
Shyamasundar Balasubramanya, David Zurakowski, Michele Borisuk, Aditya K Kaza, Sitaram M Emani, Pedro J Del Nido, Christopher W Baird
OBJECTIVE: To assess the outcomes following primary tetralogy of Fallot (TOF) repair in neonates and young infants with pulmonary stenosis (PS) and pulmonary atresia and compare differences in reintervention on the right ventricular outflow tract (RVOT) among those undergoing valve sparing repair (VSR), transannular RVOT patch (TAP), and right ventricle-to-pulmonary artery (RV-PA) conduit surgeries. METHODS: Data were collected retrospectively in 101 patients who underwent TOF repair over a 10-year period between January 2005 and September 2015...
September 19, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29049912/globular-chitosan-treatment-of-bovine-jugular-veins-evidence-of-anticalcification-efficacy-in-the-subcutaneous-rat-model
#8
Anna A Krasilnikova, David S Sergeevichev, Vladislav V Fomenko, Alexander A Korobeynikov, Maria B Vasilyeva, Alexander S Yunoshev, Alexander M Karaskov, Evgeny A Pokushalov
Vascular xenografts are widely used in cardiovascular surgery as an alternative to autologous vessels and vascular allografts. Calcification is one of the main drawbacks of vascular grafts, especially among young patients and children. Among different anticalcification approaches, chitosan emerges as a highly promising candidate due to its versatility, natural origin, and biocompatibility. We investigated the anticalcification efficacy of globular chitosan ("Chitozol") as it demonstrated the improved rate of water solubility as compared with conventional linear macromolecules of chitosan...
September 14, 2017: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/29049712/easy-technique-for-emergency-fenestration-in-non-fenestrated-fontan-patients
#9
Qiang Fan, Yunfei Ling, Yabo Wang, Qi An
The Fontan procedure is a commonly used final pathway of palliation for single-ventricle physiology. Performing it without fenestration can avoid fenestration-related drawbacks, including subnormal oxygen saturation, decreased exercise tolerance, paradoxical embolization and subsequent need for closure by catheter intervention. If emergency fenestration is required, however, it is not always technically easy to perform, particularly when the atrium is posteriorly located and difficult to expose. We describe an easy technique for creating an anastomosis using a ring-supported polytetrafluoroethylene graft to the atrium for fenestration, performed in 2 patients who underwent extracardiac conduit Fontan procedures without fenestration...
July 13, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29049702/aortic-root-and-hemiarch-replacement-in-a-patient-with-loeys-dietz-and-hypoplastic-left-heart-syndromes
#10
Eltayeb Mohamed Ahmed, Alexandru Ciprian Visan, Graham Stuart, Serban Stoica
A 15-year-old patient with hypoplastic left heart syndrome underwent 3-stage palliation by the age of 3 years. He was later diagnosed with Loeys-Dietz syndrome. On follow-up imaging, the neoaorta was dilated at 50 mm in diameter. He underwent aortic root replacement with a composite valve conduit and hemiarch replacement, using a boat-shaped Dacron graft. The uncertainty of how univentricular circulation would tolerate long bypass time steered us away from a total arch replacement. His postoperative recovery was uneventful...
October 11, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29049550/mid-term-outcomes-of-congenital-mitral-valve-surgery-shone-s-syndrome-is-a-risk-factor-for-death-and-reintervention
#11
Koichi Sughimoto, Igor E Konstantinov, Yves d'Udekem, Johann Brink, Diana Zannino, Christian P Brizard
OBJECTIVES: To study the recent trends and outcomes of congenital mitral valve surgery in children. METHODS: From 2008 to 2014, 84 procedures in 66 consecutive patients (41 procedures in 31 patients with mitral stenosis and 43 procedures in 35 patients with mitral regurgitation) were retrospectively evaluated. The mean age at surgery was 4.3 ± 5.4 years, and 27 patients (41%) were neonates or infants. RESULTS: Seven (11%) patients died during the follow-up period of 3...
August 7, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29045290/the-prognostic-implications-of-two-dimensional-speckle-tracking-echocardiography-in-hypertrophic-cardiomyopathy-current-and-future-perspectives
#12
Thomas Zegkos, Despoina Parcharidou, Dimitrios Ntelios, Georgios Efthimiadis, Haralambos Karvounis
Two-dimensional (2D) speckle tracking echocardiography represents a novel, simple and reproducible technique for the estimation of left ventricular myocardial deformation (strain) and the evaluation of left ventricular twist mechanics. During the last few years, its clinical and prognostic implications in cardiomyopathies and hypertrophic cardiomyopathy (HCM) in particular have been rapidly increasing. Reduced global longitudinal strain is associated with more severe disease and confers an increased risk for major cardiac events, independently of other clinical and echocardiographic risk factors...
October 17, 2017: Cardiology in Review
https://www.readbyqxmd.com/read/29042164/pediatrics-spanish-registry-of-percutaneous-melody-pulmonary-valve-implantation-in-patients-younger-than-18-years
#13
Ruth Solana-Gracia, Fernando Rueda, Pedro Betrián, Federico Gutiérrez-Larraya, María Jesús Del Cerro, Manuel Pan, Juan Alcíbar, José Félix Coserría, José Manuel Velasco, José Luis Zunzunegui
INTRODUCTION AND OBJECTIVES: A decade has passed since the first Spanish percutaneous pulmonary Melody valve implant (PPVI) in March 2007. Our objective was to analyze its results in terms of valvular function and possible mid-term follow-up complications. METHODS: Spanish retrospective descriptive multicenter analysis of Melody PPVI in patients < 18 years from the first implant in March 2007 until January 1, 2016. RESULTS: Nine centers were recruited with a total of 81 PPVI in 77 pediatric patients, whose median age and weight were 13...
October 14, 2017: Revista Española de Cardiología
https://www.readbyqxmd.com/read/29037360/factors-influencing-peripheral-venous-pressure-in-an-experimental-model
#14
Seshadri Raju, William Crim, William Buck
BACKGROUND: Peripheral venous hypertension and microvascular injury have merged as central features of chronic venous disease. Peripheral venous pressure in the lower limb is controlled by central and peripheral mechanisms. In the current manuscript, we examine the role of peripheral factors, particularly conduit capacitance compliance, focal stenosis, and arterial inflow into the calf. METHODS: An experimental venous model using Penrose tubing as a venous analogue was used where the aforementioned parameters could be manipulated...
November 2017: Journal of Vascular Surgery. Venous and Lymphatic Disorders
https://www.readbyqxmd.com/read/29034225/the-perception-of-a-three-dimensional-printed-heart-model-from-the-perspective-of-different-stakeholders-a-complex-case-of-truncus-arteriosus
#15
Giovanni Biglino, Sarah Moharem-Elgamal, Matthew Lee, Robert Tulloh, Massimo Caputo
The case of an 11-year-old male patient with truncus arteriosus is presented. The patient has a right aortic arch, a repaired truncus arteriosus, pulmonary artery stenosis, as well as conduit stenosis, with a complex surgical plan being discussed. In order to gather additional insight into the patient's anatomy prior to the surgery and to facilitate communication with the patient's parents, a three-dimensional (3D) model of his heart and main vessels was created from computed tomography data. Feedback was collected from different stakeholders...
2017: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/29034014/improving-the-outcome-of-vein-grafts-should-vascular-surgeons-turn-veins-into-arteries
#16
REVIEW
Toshihiko Isaji, Takuya Hashimoto, Kota Yamamoto, Jeans M Santana, Bogdan Yatsula, Haidi Hu, Hualong Bai, Guo Jianming, Tambudzai Kudze, Toshiya Nishibe, Alan Dardik
Autogenous vein grafts remain the gold standard conduit for arterial bypass, particularly for the treatment of critical limb ischemia. Vein graft adaptation to the arterial environment, i.e., adequate dilation and wall thickening, contributes to the superior performance of vein grafts. However, abnormal venous wall remodeling with excessive neointimal hyperplasia commonly causes vein graft failure. Since the PREVENT trials failed to improve vein graft outcomes, new strategies focus on the adaptive response of the venous endothelial cells to the post-surgical arterial environment...
March 24, 2017: Annals of Vascular Diseases
https://www.readbyqxmd.com/read/29033195/national-surgical-quality-improvement-program-surgical-risk-calculator-poorly-predicts-complications-in-patients-undergoing-radical-cystectomy-with-urinary-diversion
#17
Shay Golan, Melanie A Adamsky, Scott C Johnson, Nimrod S Barashi, Zachary L Smith, Maria V Rodriguez, Chuanhong Liao, Norm D Smith, Gary D Steinberg, Arieh L Shalhav
PURPOSE: To evaluate the accuracy of the American College of Surgeons National Surgical Quality Improvement Programs (ACS-NSQIP) surgical risk calculator in patients undergoing radical cystectomy (RC) with urinary diversion. MATERIALS AND METHODS: Preoperative characteristics of patients who underwent RC with ileal conduit or orthotropic neobladder (ONB) between 2007 and 2016 were entered into the proprietary online ACS-NSQIP calculator to generate 30-day predicted risk profiles...
October 12, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/29030399/robust-lysosomal-calcium-signaling-through-channel-trpml1-is-impaired-by-lysosomal-lipid-accumulation
#18
Néstor Más Gómez, Wennan Lu, Jason C Lim, Kirill Kiselyov, Keith E Campagno, Yulia Grishchuk, Susan A Slaugenhaupt, Bruce A Pfeffer, Steven J Fliesler, Claire H Mitchell
The transient receptor potential cation channel mucolipin 1 (TRPML1) channel is a conduit for lysosomal calcium efflux, and channel activity may be affected by lysosomal contents. The lysosomes of retinal pigmented epithelial (RPE) cells are particularly susceptible to build-up of lysosomal waste products because they must degrade the outer segments phagocytosed daily from adjacent photoreceptors; incomplete degradation leads to accumulation of lipid waste in lysosomes. This study asks whether stimulation of TRPML1 can release lysosomal calcium in RPE cells and whether such release is affected by lysosomal accumulations...
October 13, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29029631/neurotrophic-support-by-traumatized-muscle-derived-multipotent-progenitor-cells-role-of-endothelial-cells-and-vascular-endothelial-growth-factor-a
#19
Heidi R H Zupanc, Peter G Alexander, Rocky S Tuan
BACKGROUND: Adult mesenchymal stem cells (MSCs) have been shown to increase nerve regeneration in animal models of nerve injury. Traumatized muscle-derived multipotent progenitor cells (MPCs) share important characteristics with MSCs and are isolated from severely damaged muscle tissue following surgical debridement. Previous investigations have shown that MPCs may be induced to increase production of several neurotrophic factors, suggesting the possible utility of autologous MPCs in peripheral nerve regeneration following injury...
October 13, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29029050/small-sized-conduits-in-the-right-ventricular-outflow-tract-in-young-children-bicuspidalized-homografts-are-a-good-alternative-to-standard-conduits
#20
Katrien François, Katya De Groote, Kristof Vandekerckhove, Hans De Wilde, Daniel De Wolf, Thierry Bové
OBJECTIVES: Downsizing a homograft (HG) through bicuspidalization has been used for more than 2 decades to overcome the shortage of small-sized conduits for reconstruction of the right ventricular outflow tract (RVOT) in young children. Our goal was to investigate the durability of bicuspidalized HGs compared with other small HGs. METHODS: A retrospective analysis of 93 conduits ≤20 mm, implanted over 23 years, was performed. The end-points were survival, structural valve degeneration and conduit replacement...
October 3, 2017: European Journal of Cardio-thoracic Surgery
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