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Morphometric

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https://www.readbyqxmd.com/read/28221991/detecting-clinically-meaningful-shape-clusters-in-medical-image-data-metrics-analysis-for-hierarchical-clustering-applied-to-healthy-and-pathological-aortic-arches
#1
Jan L Bruse, Maria A Zuluaga, Abbas Khushnood, Kristin McLeod, Hopewell N Ntsinjana, Tain-Yen Hsia, Maxime Sermesant, Xavier Pennec, Andrew M Taylor, Silvia Schievano
OBJECTIVE: Today's growing medical image databases call for novel processing tools to structure the bulk of data and extract clinically relevant information. Unsupervised hierarchical clustering may reveal clusters within anatomical shape data of patient populations as required for modern Precision Medicine strategies. Few studies have applied hierarchical clustering techniques to three-dimensional patient shape data and results depend heavily on the chosen clustering distance metrics and linkage functions...
February 16, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28220615/identification-of-sperm-morphometric-subpopulations-in-cooled-stored-canine-sperm-and-its-relation-with-sperm-dna-integrity
#2
M Urbano, I Ortiz, J Dorado, M Hidalgo
The aims of this study were to (i) identify different morphometric subpopulations in cooled-stored canine sperm and their patterns of distribution during cool-storage for up to 240 hr and (ii) determine whether or not morphometric sperm subpopulations (sP) are related to sperm DNA integrity. For that purpose, morphometric parameters were analysed by computer-assisted sperm analysis (CASA) and sperm DNA fragmentation (sDFi) using the sperm Halomax test. Four morphometric sperm heads subpopulations were identified: sP1 (large and rounded), sP2 (large and elongated), sP3 (small and rounded) and sP4 (small and elongated)...
February 20, 2017: Reproduction in Domestic Animals, Zuchthygiene
https://www.readbyqxmd.com/read/28220583/morphometric-analysis-of-prostate-zonal-anatomy-using-magnetic-resonance-imaging-mri-the-impact-on-age-related-changes-in-japanese-and-american-populations
#3
Toru Matsugasumi, Atsuko Fujihara, So Ushijima, Motohiro Kanazawa, Yasuhiro Yamada, Takumi Shiraishi, Fumiya Hongo, Kazumi Kamoi, Koji Okihara, Andre Luis de Castro Abreu, Masakatsu Oishi, Toshitaka Shin, Suzanne Palmer, Inderbir S Gill, Osamu Ukimura
OBJECTIVES: Magnetic resonance imaging (MRI) can be used to reliably evaluate prostate zonal anatomy. Objectives of this study was to evaluate the impact of morphometric MRI analysis of the prostate zonal anatomy on aging, prostatic hypertrophy, and lower urinary tract symptoms in patients from Japan and the USA. SUBJECTS AND METHODS: A retrospective analysis of 307 men, including Japanese (n=156) and American (n=151) patients, who consecutively underwent 3-Tesla MRI and International Prostate Symptom Score (IPSS) due to elevated PSA...
February 20, 2017: BJU International
https://www.readbyqxmd.com/read/28220482/morphological-interaction-between-the-nasal-septum-and-nasofacial-skeleton-during-human-ontogeny
#4
Matthew J Goergen, Nathan E Holton, Thorsten Grünheid
The nasal septal cartilage is thought to be a key growth center that contributes to nasofacial skeletal development. Despite the developmental influence of the nasal septum however, humans often exhibit a high frequency of septal deviation suggesting discordance in the growth between the septum and surrounding nasofacial skeleton. While there are numerous etiological factors that contribute to septal deviation, the surrounding nasofacial skeleton may also act to constrain the septum, resulting in altered patterns of growth...
February 20, 2017: Journal of Anatomy
https://www.readbyqxmd.com/read/28220476/response-of-trabecular-bone-thyroid-c-and-follicular-cells-to-synthetic-salmon-calcitonin-in-middle-aged-orchidectomized-male-rats
#5
Branko Filipović, Branka Šošić-Jurjević, Vladimir Ajdžanović, Jasmina Živanović, Nataša Ristić, Svetlana Trifunović, Verica Milošević
In contrast to studies in women, male osteoporosis is poorly understood and strictly related to advancing age. Among the first antiresorptive substances used in the prevention and treatment of osteoporosis is calcitonin (CT), a hypocalcemic hormone that potently inhibits osteoclastic bone resorption. Natural CT is produced and secreted by thyroid C-cells. The other endocrine population of thyroid cells produces thyroid hormones (TH), which also affect bone turnover. The aim of this study was to evaluate the influence of salmon CT on trabecular bone microarchitecture with special reference to effects on the structure and function of both CT- and TH-producing thyroid cells in orchidectomized (Orx) middle-aged rats...
February 20, 2017: Journal of Anatomy
https://www.readbyqxmd.com/read/28219669/combined-phylogenetic-and-morphometric-information-to-delimit-and-unify-the-triatoma-brasiliensis-species-complex-and-the-brasiliensis-subcomplex
#6
Jader Oliveira, Paula L Marcet, Daniela M Takiya, Vagner J Mendonça, Tiago Belintan, M D Bargues, Lucia Mateo, Vivian Chagas, Elaine Folly-Ramos, Pedro Cordeiro-Estrela, Rodrigo Gurgel-Gonçalves, Jane Costa, João A Rosa, Carlos E Almeida
"Triatoma brasiliensis species complex" was defined as a monophyletic group of the species: T. brasiliensis, T. juazeirensis, T. melanica, and T. sherlocki. An alternative grouping scheme proposed the concept of "Brasiliensis subcomplex" which included the former species together with T. melanocephala, T. petrocchiae, T. lenti, T. tibiamaculata, and T. vitticeps. To evaluate the relationship among these taxa we combined the results obtained with four mitochondrial genes (12S, 16S, COI and Cytb, adding to 1,811bp) and geometric morphometric analysis of wings and heads...
February 17, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28218215/correlation-between-condylar-fracture-pattern-after-parasymphyseal-impact-and-condyle-morphological-features-a-retrospective-analysis-of-107-chinese-patients
#7
Lu Han, Ting Long, Wei Tang, Lei Liu, Wei Jing, Wei-Dong Tian, Jie Long
BACKGROUND: The treatment of the condylar fractures is difficult. Factors that result in the fractures are complex. The objective of this morphometric study was to investigate the relationship between condylar fracture patterns and condylar morphological characteristics. METHODS: We conducted a retrospective analysis of 107 patients admitted to the West China Hospital of Stomatology for bilateral condylar fractures caused by parasymphyseal impact. The patients were divided into five groups according to the type of condylar fracture...
2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28216313/between-group-differences-in-infra-patellar-fat-pad-size-and-signal-in-symptomatic-and-radiographic-progression-of-knee-osteoarthritis-vs-non-progressive-controls-and-healthy-knees-data-from-the-fnih-biomarkers-consortium-study-and-the-osteoarthritis-initiative
#8
Anja Ruhdorfer, Franziska Haniel, Tobias Petersohn, Jan Dörrenberg, Wolfgang Wirth, Torben Dannhauer, David J Hunter, Felix Eckstein
OBJECTIVE: To examine cross-sectional and longitudinal between-group differences of infra-patellar fat pad (IPFP) size and magnetic resonance imaging (MRI) signal from fat-suppressed intermediate-weighted images with clinically relevant symptomatic and radiographic progression of knee osteoarthritis (OA), versus healthy references. METHODS: We studied 110 case knees (KLG1-3) with radiographic (≥0.7mm loss in joint space width) and symptomatic progression (≥+9/100units on the WOMAC knee pain subscale) vs...
February 12, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28215868/libyostrongylus-douglassii-strongylida-trichostrongylidae-in-ostrich-struthio-camelus-farms-from-colombia
#9
Guillermo A Mariño-González, Alejandro Ramírez-Hernández, Jesús A Cortés-Vecino
Ostrich farming is an important livestock industry in different world regions with a diverse offer of products and services. In Colombia, as in other countries, this market led the importation of animals from countries like Canada, United States of America and South Africa for breeding objectives. With the animals, specific pathogens for these ratites could be introduced. Libyostrongylus spp. is a strongylid nematode with worldwide distribution, which can induce a severe disease and mortality in infected animals...
February 15, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28215575/fibronectin-connecting-segment-1-peptide-inhibits-pathogenic-leukocyte-trafficking-and-inflammatory-demyelination-in-experimental-models-of-chronic-inflammatory-demyelinating-polyradiculoneuropathy
#10
Chaoling Dong, Kelsey M Greathouse, Rebecca L Beacham, Steven P Palladino, E Scott Helton, Eroboghene E Ubogu
The molecular determinants of pathogenic leukocyte migration across the blood-nerve barrier (BNB) in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) are unknown. Specific disease modifying therapies for CIDP are also lacking. Fibronectin connecting segment-1 (FNCS1), an alternatively spliced fibronectin variant expressed by microvascular endothelial cells at sites of inflammation in vitro and in situ, is a counterligand for leukocyte α4 integrin (also known as CD49d) implicated in pathogenic leukocyte trafficking in multiple sclerosis and inflammatory bowel disease...
February 16, 2017: Experimental Neurology
https://www.readbyqxmd.com/read/28215573/molecular-and-morphometric-data-suggest-the-presence-of-a-neglected-species-in-the-marine-gastropod-family-conidae
#11
Alyssa J Lawler, Thomas F Duda
Knowledge concerning the taxonomic diversity of marine organisms is crucial for understanding processes associated with species diversification in geographic areas that are devoid of obvious barriers to dispersal. The marine gastropod family Conidae contains many species complexes due to lack of clear morphological distinctiveness and existence of morphological intergradations among described species. Conus flavidus Lamarck, 1810 and Conus frigidus Reeve, 1848 are currently recognized as distinct taxa, but are often difficult to distinguish by morphological characters and include several synonyms, including Conus peasei Brazier, 1877...
February 16, 2017: Molecular Phylogenetics and Evolution
https://www.readbyqxmd.com/read/28215318/dietary-corn-fractions-reduce-atherogenesis-in-low-density-lipoprotein-receptor-knockout-mice
#12
Kabo Masisi, Khuong Le, Nora Ghazzawi, Mohammed H Moghadasian, Trust Beta
Accumulating evidence has suggested that intake of whole grains is a protective factor against pathogenesis of coronary artery disease. The exact mechanisms, however, are still not clearly understood. In this study, we hypothesized that adequate intake of corn fractions (aleurone, endosperm and germ) can modify lipid profiles in relation to atherosclerotic lesion development in low-density lipoprotein receptor knockout (LDLr-KO) mice. The purpose of the present study was to investigate the potential cardiovascular benefits of corn fractions in LDLr-KO mice through a number of biomarkers including lipid profile, and morphologic and morphometrical analysis of atherosclerotic lesions in aortic root...
January 2017: Nutrition Research
https://www.readbyqxmd.com/read/28213639/prechiasmatic-sulcus-and-optic-strut-an-anatomic-study-in-dry-skulls
#13
Vasiliki Kanellopoulou, Evgenia Efthymiou, Vasiliki Thanopoulou, Dimitra Kozompoli, Dimitrios Mytilinaios, Maria Piagkou, Elizabeth O Johnson
BACKGROUND: Although safe surgical access to the cavernous sinus is related to understanding the anatomical and ethnic variants of the prechiasmatic sulcus and the optic strut, there remains a paucity of studies of the morphology and the bony relationships in the region. The present study provides a systematic morphological and morphometric analysis of the sulcal region and the optic strut anatomy and their relations in a Greek population. METHODS: The interoptic distance, length of planum sphenoidale, sulcal length and sulcal angle was determined in 96 Greek adult dry skulls...
February 17, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28212516/sex-disparities-in-substance-abuse-research-evaluating-23-years-of-structural-neuroimaging-studies
#14
Kimberly E Lind, Eric J Gutierrez, Dorothy J Yamamoto, Michael F Regner, Sherry A McKee, Jody Tanabe
BACKGROUND: Sex differences in brain structure and clinical course of substance use disorders underscores the need to include women in structural brain imaging studies. The NIH has supported the need for research to address sex differences. We evaluated female enrollment in substance abuse structural brain imaging research and the methods used to study sex differences in substance effects. METHODS: Structural brain imaging studies published through 2016 (n=230) were evaluated for number of participants by sex and substance use status and methods used to evaluate sex differences...
January 31, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28212452/bone-to-implant-contact-and-new-bone-formation-within-human-freeze-dried-bone-blocks-grafted-over-rabbit-calvaria
#15
Zvi Artzi, Karen Anavi-Lev, Avital Kozlovsky, Liat Chaushu, Frank Schwarz, Haim Tal
PURPOSE: To assess the extent of osseointegration with rough-surface implants and new bone formation (NBF) within human freeze-dried bone blocks (h-FDB) grafted over rabbit calvaria. MATERIALS AND METHODS: A total of 18 rectangular h-FDB blocks were stabilized bilaterally to the calvaria of nine New Zealand rabbits by two mini titanium screws each. A total of 18 rough-surface implants (5.0 × 6.0-mm) were placed, 9 simultaneously (immediate placement [IP]) on one side and 9 at 3 months after block grafting (delayed placement [DP]) on the contralateral side...
February 17, 2017: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/28210850/the-laminar-organization-of-the-motor-cortex-in-monodactylous-mammals-a-comparative-assessment-based-on-horse-chimpanzee-and-macaque
#16
Bruno Cozzi, Alberto De Giorgio, A Peruffo, S Montelli, M Panin, C Bombardi, A Grandis, A Pirone, P Zambenedetti, L Corain, Alberto Granato
The architecture of the neocortex classically consists of six layers, based on cytological criteria and on the layout of intra/interlaminar connections. Yet, the comparison of cortical cytoarchitectonic features across different species proves overwhelmingly difficult, due to the lack of a reliable model to analyze the connection patterns of neuronal ensembles forming the different layers. We first defined a set of suitable morphometric cell features, obtained in digitized Nissl-stained sections of the motor cortex of the horse, chimpanzee, and crab-eating macaque...
February 16, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/28210845/whipworm-diversity-in-west-african-rodents-a-molecular-approach-and-the-description-of-trichuris-duplantieri-n-sp-nematoda-trichuridae
#17
Alexis Ribas, Christophe Diagne, Caroline Tatard, Mamoudou Diallo, Srisupaph Poonlaphdecha, Carine Brouat
Whipworms were collected from rodents (Muridae) from six West African countries: Burkina-Faso, the Islamic Republic of Mauritania, and the Republics of Benin, Guinea, Mali and Senegal. Molecular sequences (ITS-1, 5.8S and ITS-2 of the ribosomal DNA gene) and morphometric characters were analysed in Trichuris (Nematoda: Trichuridae) specimens found in seven host species: Arvicanthis niloticus, Gerbilliscus gambianus, Gerbillus gerbillus, G. tarabuli, Mastomys erythroleucus, M. huberti and M. natalensis. Phylogenetic analyses revealed three clades, one recognised as Trichuris mastomysi, previously recorded in M...
February 16, 2017: Parasitology Research
https://www.readbyqxmd.com/read/28208700/role-of-protein-quality-control-failure-in-alcoholic-hepatitis-pathogenesis
#18
REVIEW
Samuel W French, Maryam Masouminia, Sara Samadzadeh, Brittany C Tillman, Alejandro Mendoza, Barbara A French
: The mechanisms of protein quality control in hepatocytes in cases of alcoholic hepatitis (AH) including ufmylation, FAT10ylation, metacaspase 1 (Mca1), ERAD (endoplasmic reticulum-associated degradation), JUNQ (juxta nuclear quality control), IPOD (insoluble protein deposit) autophagocytosis, and ER stress are reviewed. The Mallory-Denk body (MDB) formation develops in the hepatocytes in alcoholic hepatitis as a consequence of the failure of these protein quality control mechanisms to remove misfolded and damaged proteins and to prevent MDB aggresome formation within the cytoplasm of hepatocytes...
February 8, 2017: Biomolecules
https://www.readbyqxmd.com/read/28207769/role-of-glycogen-synthase-kinase-3%C3%AE-and-ppar-%C3%AE-on-epithelial-to-mesenchymal-transition-in-dss-induced-colorectal-fibrosis
#19
Jacopo Di Gregorio, Roberta Sferra, Silvia Speca, Antonella Vetuschi, Caroline Dubuquoy, Pierre Desreumaux, Simona Pompili, Loredana Cristiano, Eugenio Gaudio, Vincenzo Flati, Giovanni Latella
BACKGROUND: Intestinal fibrosis is characterized by abnormal production and deposition of extracellular matrix (ECM) proteins by activated myofibroblasts. The main progenitor cells of activated myofibroblasts are the fibroblasts and the epithelial cells, the latter through the epithelial-mesenchymal transition (EMT). AIM: To evaluate the action of the new PPAR-γ modulator, GED-0507-34 Levo (GED) on the expression of EMT associated and regulatory proteins such as TGF-β, Smad3, E-cadherin, Snail, ZEB1, β-catenin, and GSK-3β, in a mouse model of DSS-induced intestinal fibrosis...
2017: PloS One
https://www.readbyqxmd.com/read/28207625/a-three-dimensional-geometric-morphometric-study-to-quantify-temporal-bone-growth-and-its-consequences-for-the-success-of-implanting-bone-anchored-hearing-devices
#20
Sebastian Schilde, Stefan K Plontke, Torsten Rahne
OBJECTIVE: A computed tomography (CT)-based morphological-investigation to describe temporal bone growth and to devise a predictive test of the likely success of Bonebridge implantation into the growing mastoid region of the temporal bone in young patients. STUDY DESIGN: Retrospective cross-sectional study. SETTING: University Hospital Halle (Saale), Germany. PATIENTS: Two cohorts participated. This first, of patients aged less than 21 years, comprised 42 men, and 33 women patients...
February 15, 2017: Otology & Neurotology
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