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https://www.readbyqxmd.com/read/28427257/effect-of-dietary-calcium-concentrations-in-low-non-phytate-phosphorus-diets-containing-phytase-on-growth-performance-bone-mineralization-litter-quality-and-footpad-dermatitis-incidence-in-growing-broiler-chickens
#1
Jong Hyuk Kim, Hyunjung Jung, Franco Martinez Pitargue, Gi Ppeum Han, Hyeon Seok Choi, Dong Yong Kil
Objective: An experiment was conducted to investigate the effect of dietary Ca concentrations in low non-phytate phosphorus (NPP) diets containing phytase on growth performance, bone mineralization, litter quality, and footpad dermatitis (FPD) incidence in growing broiler chickens. Methods: A total of 1,800 21-day-old Ross 308 growing broiler chickens were allotted to 1 of 6 dietary treatments with 6 replicated cages. Six diets were formulated to provide increasing Ca concentrations of 4...
April 21, 2017: Asian-Australasian Journal of Animal Sciences
https://www.readbyqxmd.com/read/28427256/effect-of-superdosing-phytase-on-productive-performance-and-egg-quality-in-laying-hens
#2
Jong Hyuk Kim, Franco Martinez Pitargue, Hyunjung Jung, Gi Ppeum Han, Hyeon Seok Choi, Dong Yong Kil
Objective: An experiment was conducted to determine the effect of superdosing phytase on productive performance and egg quality in laying hens. Methods: A total of 200 42-wk-old Hy-Line Brown laying hens were allotted into 1 of 5 dietary treatments with 5 replicates consisting of 8 hens per replicate. The positive control (PC) and negative control diets (NC) were prepared based on the recommended P levels in layer diets. Supplemental phytase was added to the negative control diet at 10,000 (SD10), 20,000 (SD20), or 30,000 (SD30) FTU/kg...
April 21, 2017: Asian-Australasian Journal of Animal Sciences
https://www.readbyqxmd.com/read/28427255/oligosaccharides-are-a-key-factor-in-prediction-of-amino-acid-digestibility-in-soybean-meal-of-different-origins-when-fed-to-growing-pigs
#3
Zhongchao Li, Qiuyun Wang, Fei Xie, Dewen Liu, Yakui Li, Zhiqian Lyu, Changhua Lai
Objective: The objective of this experiment was to determine apparent ileal digestibility (AID) and standardized ileal digestibility (SID) of CP and AA in 15 sources of soybean meal (SBM) produced from soybeans from different countries and subsequently to establish equations for predicting the AID and SID in SBM based on their chemical composition. Methods: Eighteen barrows (57.9 6.1 kg) fitted with a simple T-cannula were allotted into three 6 × 6 Latin square designs...
April 21, 2017: Asian-Australasian Journal of Animal Sciences
https://www.readbyqxmd.com/read/28427254/supplementing-the-culture-of-rhodobacter-sphaeroides-in-the-diet-of-holstein-lactating-cow-may-naturally-produce-coenzyme-q10-enriched-milk
#4
Gui-Seck Bae, Ahreum Choi, Joon Mo Yeo, Jong Nam Kim, Jaeyong Song, Eun Joong Kim, Moon Baek Chang
Objective: To examine the effects of Rhaodobacter sphaeroides supplementation as a direct-fed microbial (DFM) on rumen fermentation in dairy cows and on CoQ10 transition into milk, an in vitro rumen simulation batch culture and an in vivo dairy cow experiments were conducted. Methods: The characteristics of in vitro ruminal fermentation were investigated using rumen fluids from six cannulated Holstein dairy cows at 2 h post-afternoon feeding. A control treatment was included in the experiments based on a typified total mixed ration (TMR) for lactating dairy cows, which was identical to the one used in the in vivo study, plus R...
April 21, 2017: Asian-Australasian Journal of Animal Sciences
https://www.readbyqxmd.com/read/28427253/meta-analysis-of-the-correlation-between-the-rs17401966-polymorphism-in-kinesin-family-member-1b-and-susceptibility-to-hepatitis-b-virus-related-hepatocellular-carcinoma
#5
Mingkuan Su, Jianfeng Guo, Jiancheng Huang
Background/Aims: The association between the kinesin family member 1B (KIF1B) gene polymorphism and the risk of hepatitis B virus-related hepatocellular carcinoma (HCC) has been investigated in many peer-reviewed studies. However, scholars have failed to replicate these results in validation tests. The purpose of the present study was to explore whether the KIF1B rs17401966 polymorphism was associated with susceptibility to HCC. Methods: The results of case-controlled studies on the correlation between the KIF1B rs17401966 polymorphism and HCC susceptibility were collected using Google Scholar and the EMBASE, PubMed and CNKI databases...
April 21, 2017: Clinical and Molecular Hepatology
https://www.readbyqxmd.com/read/28427236/combined-effects-of-glutathione-s-transferase-m1-and-t1-polymorphisms-on-risk-of-lung-cancer-evidence-from-a-meta-analysis
#6
Ying Gao, Fei Gao, Ting-Ting Hu, Gang Li, Yan-Xia Sui
Many studies have reported an association between the glutathione S-transferase M1 null and T1 null polymorphisms and lung cancer risk. However, the combined effects of GSTM1 null and GSTT1 null polymorphisms have not been reported previously. We, therefore, performed a meta-analysis to investigate the combined effects. 40 publications with 44 case-control studies were selected in the meta-analysis, including 13,706 cases and 13,093 controls. Significant association was observed between the combined effects of GSTM1 and GSTT1 polymorphisms and lung cancer risk when all the eligible studies were pooled into the meta-analysis...
March 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/28427232/embryonic-signature-distinguishes-pediatric-and-adult-rhabdoid-tumors-from-other-smarcb1-deficient-cancers
#7
Wilfrid Richer, Julien Masliah-Planchon, Nathalie Clement, Irene Jimenez, Laetitia Maillot, David Gentien, Benoît Albaud, Walid Chemlali, Christine Galant, Frederique Larousserie, Pascaline Boudou-Rouquette, Amaury Leruste, Celine Chauvin, Zhi Yan Han, Jean-Michel Coindre, Pascale Varlet, Paul Freneaux, Dominique Ranchère-Vince, Olivier Delattre, Franck Bourdeaut
Extra-cranial rhabdoid tumors (RT) are highly aggressive malignancies of infancy, characterized by undifferentiated histological features and loss of SMARCB1 expression. The diagnosis is all the more challenging that other poorly differentiated cancers lose SMARCB1 expression, such as epithelioid sarcomas (ES), renal medullary carcinomas (RMC) or undifferentiated chordomas (UC). Moreover, late cases occurring in adults are now increasingly reported, raising the question of differential diagnoses and emphasizing nosological issues...
March 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/28427220/multiparametric-imaging-using-18f-fdg-pet-ct-heterogeneity-parameters-and-functional-mri-techniques-prognostic-significance-in-patients-with-primary-advanced-oropharyngeal-or-hypopharyngeal-squamous-cell-carcinoma-treated-with-chemoradiotherapy
#8
Sheng-Chieh Chan, Nai-Ming Cheng, Chia-Hsun Hsieh, Shu-Hang Ng, Chien-Yu Lin, Tzu-Chen Yen, Cheng-Lung Hsu, Hung-Ming Wan, Chun-Ta Liao, Kai-Ping Chang, Jiun-Jie Wang
BACKGROUND: In this study, PET heterogeneity was combined with functional MRI techniques to refine the prediction of prognosis in patients with oropharyngeal or hypopharyngeal squamous cell carcinoma (OHSCC). METHODS: A total of 124 patients with primary advanced OHSCC who underwent pretreatment 18F-FDG PET/CT, dynamic contrast-enhanced MR imaging (DCE-MRI), and diffusion-weighted MR imaging (DWI) were enrolled. Conventional and heterogeneity parameters from 18F-FDG PET as well as perfusion parameters from DCE-MRI and diffusion parameter from DWI of primary tumors were analyzed in relation to recurrence-free survival (RFS) and overall survival (OS)...
March 4, 2017: Oncotarget
https://www.readbyqxmd.com/read/28427215/top2a-ggh-and-pecam1-are-associated-with-hematogenous-lymph-node-and-peritoneal-recurrence-in-stage-ii-iii-gastric-cancer-patients-enrolled-in-the-acts-gc-study
#9
Masanori Terashima, Wataru Ichikawa, Atsushi Ochiai, Koji Kitada, Issei Kurahashi, Shinichi Sakuramoto, Hitoshi Katai, Takeshi Sano, Hiroshi Imamura, Mitsuru Sasako
BACKGROUND: To identify factors related to relapse sites, we carried out an exploratory biomarker analysis of data from the Adjuvant Chemotherapy Trial of TS-1 for Gastric Cancer study, which is a randomized, controlled trial comparing postoperative adjuvant S-1 therapy with surgery alone in 1,059 patients with stage II/III gastric cancer. PATIENTS AND METHODS: Surgical specimens from 829 patients were retrospectively examined, and 63 genes involved in a variety of biological processes were analyzed by quantitative real-time PCR...
March 4, 2017: Oncotarget
https://www.readbyqxmd.com/read/28427214/high-mucin-5ac-expression-predicts-adverse-postoperative-recurrence-and-survival-of-patients-with-clear-cell-renal-cell-carcinoma
#10
Haijian Zhang, Yidong Liu, Huyang Xie, Weisi Liu, Qiang Fu, Dengfu Yao, Jiejie Xu, Jianxin Gu
BACKGROUND: Mucin 5AC (MUC5AC), as a member of secreted/gel-forming mucin family, was frequently found to be abnormally expressed in inflammation or malignant diseases. However, the clinic pathologic features and prognostic values of MUC5AC in clear-cell renal cell carcinoma (ccRCC) have not been reported up to now. METHODS: MUC5AC expression was analyzed by immunohistochemistry on tissue microarrays. Kaplan-Meier survival curves, Univariate and Multivariate Cox analysis and newly-established nomogram model were performed to evaluate the prognostic value...
March 4, 2017: Oncotarget
https://www.readbyqxmd.com/read/28427212/high-myc-expression-and-transcription-activity-underlies-intra-tumoral-heterogeneity-in-triple-negative-breast-cancer
#11
Nidhi Gupta, Karen Jung, Chengsheng Wu, Abdulraheem Alshareef, Hind Alqahtani, Sambasivarao Damaraju, John R Mackey, Sunita Ghosh, Siham Sabri, Bassam S Abdulkarim, Gilbert Bigras, Raymond Lai
We have previously identified a novel intra-tumoral dichotomy in triple-negative breast cancer (TNBC) based on the differential responsiveness to a reporter containing the Sox2 regulatory region-2 (SRR2), with reporter responsive (RR) cells being more stem-like than reporter unresponsive (RU) cells. Using bioinformatics, we profiled the protein-DNA binding motifs of SRR2 and identified Myc as one of the potential transcription factors driving SRR2 activity. In support of its role, Myc was found to be highly expressed in RR cells as compared to RU cells...
March 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/28427203/regional-structural-impairments-outside-lesions-are-associated-with-verbal-short-term-memory-deficits-in-chronic-subcortical-stroke
#12
Qingqing Diao, Jingchun Liu, Caihong Wang, Jingliang Cheng, Tong Han, Xuejun Zhang
BACKGROUND AND PURPOSE: We aimed to explore the neural mechanisms of verbal short-term memory (VSTM) impairment in subcortical stroke by evaluating the contributions of lesion and remote grey matter volume (GMV) reduction. RESULTS: There was no significant correlation between lesions and VSTM. In stroke patients with left lesions, GMV reductions in the right middle frontal gyrus and in the left inferior frontal gyrus were positively correlated with VSTM impairment...
March 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/28427196/breast-cancer-subtypes-predict-the-preferential-site-of-distant-metastases-a-seer-based-study
#13
Qi Wu, Juanjuan Li, Shan Zhu, Juan Wu, Chuang Chen, Qian Liu, Wen Wei, Yimin Zhang, Shengrong Sun
BACKGROUND AND AIMS: This study aimed to access possible relationships between breast cancer subtypes and sites of distant metastasis in breast cancer. RESULTS: A total of 243,896 patients, including 226,451 cases in control groups were identified. Bone metastasis was found in 8848 cases, compared with 1,000 brain metastasis cases, 3434 liver metastasis cases and 4167 lung metastasis cases. Patients with all subtypes were most prone to bone metastases, the incidence of bone metastasis in HR+/HER2+ subtype was up to 5...
March 2, 2017: Oncotarget
https://www.readbyqxmd.com/read/28427185/transcriptional-landscape-of-human-cancers
#14
Mengyuan Li, Qingrong Sun, Xiaosheng Wang
The homogeneity and heterogeneity in somatic mutations, copy number alterations and methylation across different cancer types have been extensively explored. However, the related exploration based on transcriptome data is lacking. In this study we explored gene expression profiles across 33 human cancer types using The Cancer Genome Atlas (TCGA) data. We identified consistently upregulated genes (such as E2F1, EZH2, FOXM1, MYBL2, PLK1, TTK, AURKA/B and BUB1) and consistently downregulated genes (such as SCARA5, MYOM1, NKAPL, PEG3, USP2, SLC5A7 and HMGCLL1) across various cancers...
March 2, 2017: Oncotarget
https://www.readbyqxmd.com/read/28427183/random-walk-based-method-to-identify-prognostic-genes-in-colorectal-cancer
#15
Xue Yang, Chen Zhao, Ning An
Currently, colorectal cancer remains one of the major causes of cancer mortality worldwide, despite significant advances in understanding its molecular mechanism. It has been putatively accepted that CRC, in most case, is a highly complicated process through adenoma-carcinoma sequence. Therefore, thorough researches regarding the molecular abnormalities, especially in precancerous stage, might be helpful in discovering potential biomarkers and promising therapeutic targets. Moreover, differentially expressed genes consistently dysregulated throughout the whole carcinogenic process might substantially reduce potential noise created by large-scale tumor heterogeneity...
March 2, 2017: Oncotarget
https://www.readbyqxmd.com/read/28427177/an-endoscopic-ultrasonography-guided-interstitial-brachytherapy-based-special-treatment-planning-system-for-unresectable-pancreatic-cancer
#16
Xiaotian Sun, Zheng Lu, Yijun Wu, Min Min, Yiliang Bi, Wei Shen, Yang Xu, Zhaoshen Li, Zhendong Jin, Yan Liu
EUS-guided interstitial brachytherapy is promising in the treatment of unresectable malignant carcinoma adjacent to the digestive tract. The feasible treatment plan is not established. Thus, our study aimed to develop a novel treatment plan and evaluate the feasibility in patients with unresectable pancreatic cancer. A total of 42 patients with unresectable pancreatic cancer (stage III: n = 18; stage IV: n = 24) were retrospectively included. A special treatment-planning system (TPS) for EUS was designed and evaluated by comparing with the traditional TPS...
February 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28427173/circumvent-the-uncertainty-in-the-applications-of-transcriptional-signatures-to-tumor-tissues-sampled-from-different-tumor-sites
#17
Jun Cheng, You Guo, Qiao Gao, Hongdong Li, Haidan Yan, Mengyao Li, Hao Cai, Weicheng Zheng, Xiangyu Li, Weizhong Jiang, Zheng Guo
The expression measurements of thousands of genes are correlated with the proportions of tumor epithelial cell (PTEC) in clinical samples. Thus, for a tumor diagnostic or prognostic signature based on a summarization of expression levels of the signature genes, the risk score for a patient may dependent on the tumor tissues sampled from different tumor sites with diverse PTEC for the same patient. Here, we proposed that the within-samples relative expression orderings (REOs) based gene pairs signatures should be insensitive to PTEC variations...
February 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28427162/effect-of-age-on-long-term-outcomes-after-stroke-with-atrial-fibrillation-a-hospital-based-follow-up-study-in-china
#18
Tao Wang, Bin Li, Hongfei Gu, Yongzhong Lou, Xianjia Ning, Jinghua Wang, Zhongping An
Atrial fibrillation (AF) is an established predictor of poor outcomes after stroke. We aimed to assess the effect of age on outcomes at 1 year and 3 years in stroke patients with AF.We recruited acute ischemic stroke patients with AF between January 2006 and September 2014 in Tianjin, China. Clinical features and outcomes at 1 year and 3 years after stroke were compared between younger group and elderly group. Overall, 951 consecutive stroke patients with AF were included in this study. There was a higher mortality and dependency rate in the elderly group than in the young group at both 1 and 3 years after stroke...
February 25, 2017: Oncotarget
https://www.readbyqxmd.com/read/28427144/human-papillomavirus-infection-as-a-prognostic-marker-for-lung-adenocarcinoma-a-systematic-review-and-meta-analysis
#19
Lanwei Guo, Shuzheng Liu, Shaokai Zhang, Qiong Chen, Meng Zhang, Peiliang Quan, Xibin Sun
Although a number of studies have investigated the association between human papillomavirus (HPV) and lung cancer prognosis, the results remain inconsistent. We therefore conducted a meta-analysis of epidemiologic studies to address this issue. Searches of the MEDLINE and EMBASE electronic databases from their inception until June 30, 2016 yielded nine studies involving a total of 1,205 lung cancer cases that were used to conduct the meta-analysis. Study-specific risk estimates were pooled using a random-effects model...
February 24, 2017: Oncotarget
https://www.readbyqxmd.com/read/28427143/activity-induced-spontaneous-spikes-in-gabaergic-neurons-suppress-seizure-discharges-an-implication-of-computational-modeling
#20
Wei Lu, Jing Feng, Bo Wen, Kewei Wang, Jin-Hui Wang
BACKGROUND: Epilepsy, a prevalent neurological disorder, appears self-termination. The endogenous mechanism for seizure self-termination remains to be addressed in order to develop new strategies for epilepsy treatment. We aim to examine the role of activity-induced spontaneous spikes at GABAergic neurons as an endogenous mechanism in the seizure self-termination. METHODS AND RESULTS: Neuronal spikes were induced by depolarization pulses at cortical GABAergic neurons from temporal lobe epilepsy patients and mice, in which some of these neurons fired activity-induced spontaneous spikes...
February 23, 2017: Oncotarget
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