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https://www.readbyqxmd.com/read/27921204/a-case-of-double-depressor-palsy-followed-by-pursuit-deficit-due-to-sequential-infarction-in-bilateral-thalamus-and-right-medial-superior-temporal-area
#1
Su Jin Kim, Myeong In Yeom, Seung Uk Lee
BACKGROUND: We present a unique case of a patient who suffered two rare events affecting the supranuclear control, first of the vertical and second of the horizontal eye movements. The first event involved bilateral thalamic infarcts that resulted in double depressor palsy. The second event occurred 1 year later and it involved supranuclear control of horizontal eye movements creating pursuit deficit. CASE PRESENTATION: A 47-year-old male presented with complaints of diplopia upon awakening...
December 5, 2016: International Ophthalmology
https://www.readbyqxmd.com/read/27909402/upright-perception-and-ocular-torsion-change-independently-during-head-tilt
#2
Jorge Otero-Millan, Amir Kheradmand
We maintain a stable perception of the visual world despite continuous movements of our eyes, head and body. Perception of upright is a key aspect of such orientation constancy. Here we investigated whether changes in upright perception during sustained head tilt were related to simultaneous changes in torsional position of the eyes. We used a subjective visual vertical (SVV) task, modified to track changes in upright perception over time, and a custom video method to measure ocular torsion simultaneously. We tested 12 subjects in upright position, during prolonged (~15 min) lateral head tilts of 20 degrees, and also after the head returned to upright position...
2016: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/27903814/blink-associated-contralateral-eccentric-saccades-as-a-rare-sign-of-unilateral-brain-injury
#3
Ilaria Zivi, Eugenio Bertelli, Giacinta Bilotti, Ignazio Alessandro Clemente, Leopold Saltuari, Giuseppe Frazzitta
OBJECTIVE: To describe a rare sign of unilateral brain injury as a form of unwanted blink-associated contralateral eccentric saccades. METHODS: A 62-year-old patient who underwent an ischemic stroke affecting the entire right middle cerebral artery territory came to our attention 1 year after stroke, manifesting with transient contralateral conjugate gaze deviations associated with spontaneous blinking. We complemented the regular neurologic evaluation with brain MRI, study of evoked potentials, electroneurography of the facial nerve, and infrared video-oculoscopy...
November 30, 2016: Neurology
https://www.readbyqxmd.com/read/27900813/anesthesia-maintenance-with-induction-dose-only-sevoflurane-during-pediatric-ophthalmic-examination-comparison-with-standard-low-flow-technique-through-a-randomized-controlled-trial
#4
Priyankar K Datta, Renu Sinha, Bikash Ranjan Ray, Venkateswaran Jambunathan, Riddhi Kundu
BACKGROUND: Sevoflurane is preferred for pediatric day care procedures. However, financial and environmental costs remain major limitations. Induction dose of sevoflurane could itself be sufficient for maintaining anesthesia with low fresh gas flow during short noninvasive procedures. METHODS: Fifty children, aged 1-5 years, scheduled for ophthalmic examination under anesthesia, were randomized into two groups. All children were induced with 8% sevoflurane in O2 : N2 O (40 : 60)...
November 30, 2016: Paediatric Anaesthesia
https://www.readbyqxmd.com/read/27891684/changes-in-visibility-as-a-function-of-spatial-frequency-and-microsaccade-occurrence
#5
Francisco M Costela, Michael B McCamy, Mary Coffelt, Jorge Otero-Millan, Stephen Macknik, Susana Martinez-Conde
Fixational eye movements (FEM), including microsaccades, drift, and tremor, shift our eye position during ocular fixation, producing retinal motion that is thought to help visibility by counteracting neural adaptation to unchanging stimulation. Yet, how each FEM type influences this process is still debated. Recent studies found little to no relationship between microsaccades and visual perception of spatial frequencies (SF), and concluded that any effects microsaccades may have on vision do not extend to the SF domain...
November 27, 2016: European Journal of Neuroscience
https://www.readbyqxmd.com/read/27877114/ontogenetic-development-of-vestibulo-ocular-reflexes-in-amphibians
#6
REVIEW
Francisco Branoner, Boris P Chagnaud, Hans Straka
Vestibulo-ocular reflexes (VOR) ensure gaze stability during locomotion and passively induced head/body movements. In precocial vertebrates such as amphibians, vestibular reflexes are required very early at the onset of locomotor activity. While the formation of inner ears and the assembly of sensory-motor pathways is largely completed soon after hatching, angular and translational/tilt VOR display differential functional onsets and mature with different time courses. Otolith-derived eye movements appear immediately after hatching, whereas the appearance and progressive amelioration of semicircular canal-evoked eye movements is delayed and dependent on the acquisition of sufficiently large semicircular canal diameters...
2016: Frontiers in Neural Circuits
https://www.readbyqxmd.com/read/27875130/discriminative-ocular-artifact-correction-for-feature-learning-in-eeg-analysis
#7
Xinyang Li, Cuntai Guan, Haihong Zhang, Kai Keng Ang
Electrooculogram (EOG) artifact contamination is a common critical issue in general electroencephalogram (EEG) studies as well as in brain computer interface (BCI) research. It is especially challenging when dedicated EOG channels are unavailable or when there are very few EEG channels available for ICA-based ocular artifact removal. It is even more challenging to avoid loss of the signal of interest during the artifact correction process, where the signal of interest can be multiple magnitudes weaker than the artifact...
November 16, 2016: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/27874249/role-of-neural-integrators-in-oculomotor-systems-a%C3%A2-systematic-narrative-literature-review
#8
REVIEW
Katherine Sanchez, Fiona J Rowe
PURPOSE: To evaluate the role of neural integrators (NI) in the oculomotor system. METHODS: A literature search was carried out using several electronic databases during the months of June 2014 to March 2015. The following keywords were used to generate focused results: 'neural integrators', 'gaze-holding', 'oculomotor integration', 'impaired gaze-holding', 'gaze evoked nystagmus' and 'gaze dysfunction'. Further materials were found through searching relevant articles within reference lists...
November 22, 2016: Acta Ophthalmologica
https://www.readbyqxmd.com/read/27868452/closed-reduction-of-zygomatic-tripod-fractures-using-a-towel-clip
#9
Anı Cinpolat, Ozlenen Ozkan, Gamze Bektas, Omer Ozkan
BACKGROUND: The zygomatic bone constitutes the prominence of the cheek. Fractures of the zygomatic bone are the second most treatment of zygomatic bone fractures and can be examined under two headings, open and closed reductions. This paper describes a new technique in the closed reduction of tripod fractures using a towel clip. METHODS: Seventeen consecutive patients (three females, 14 males) with a mean age of 35.5 years (range = 18-66 years) with zygomatic tripod fracture were treated using the towel clip technique between December 2011 and February 2014...
November 21, 2016: Journal of Plastic Surgery and Hand Surgery
https://www.readbyqxmd.com/read/27858844/forced-duction-training-a-potential-key-point-for-recovery-in-pediatric-patients-with-trapdoor-fracture
#10
Yinwei Li, Xuefei Song, Lunhao Li, Xianqun Fan, Ming Lin
Trapdoor fracture is a type of orbital fracture frequently observed in pediatric patients after facial trauma. The treatment options and surgical outcomes associated with this fracture are controversial.This study investigated the surgery principles and strategies as well as the functional training for the recovery and prognosis of pediatric patients with trapdoor fracture.A retrospective study was conducted on 21 pediatric patients with orbital trapdoor fracture who received the transconjunctival approach for orbital defect reconstruction surgery between 2009 and 2014 at the Department of Ophthalmology, Shanghai Ninth People's Hospital...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27853019/can-a-dermoid-cyst-lead-to-an-abnormal-origin-of-an-extraocular-muscle
#11
Tayyab Afghani, Hassan Mansoor
A 5-year-old boy presented with a large 5 cm × 5 cm cyst covering the left eye completely since birth. The cyst was excised in toto and was sent for histopathological examination. During the surgery, the inferior oblique (IO) muscle was seen originating from medial orbital wall, 10-12 mm behind the medial orbital margin, just posterior to the lacrimal bone and moving laterally, downward, and posteriorly from its origin making a more acute angle - around 20° to its site of origin. The insertion of the IO to sclera was at its normal site...
September 2016: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/27852021/-neuroanatomy-of-the-parietal-association-areas
#12
Yasushi Kobayashi
The parietal association cortex comprises the superior and inferior parietal lobules, the precuneus and the cortices in the intraparietal, parietooccipital and lunate sulci. By processing somatic, visual, acoustic and vestibular sensory information, the parietal association cortex plays a pivotal role in spatial cognition and motor control of the eyes and the extremities. Sensory information from the primary and secondary somatosensory areas enters the superior parietal lobule and is transferred to the inferior parietal lobule...
November 2016: Brain and Nerve, Shinkei Kenkyū No Shinpo
https://www.readbyqxmd.com/read/27837354/congenital-cranial-dysinnervation-disorders
#13
REVIEW
Anupam Singh, P K Pandey, Ajai Agrawal, Sanjeev Kumar Mittal, Kartik Maheshbhai Rana, Chirag Bahuguna
The European Neuromuscular Centre (ENMC) derived the term Congenital Cranial Dysinnervation Disorders in 2002 at an international workshop for a group of congenital neuromuscular diseases. CCDDs are congenital, non-progressive ophthalmoplegia with restriction of globe movement in one or more fields of gaze. This group of sporadic and familial strabismus syndromes was initially referred to as the 'congenital fibrosis syndromes' because it was assumed that the primary pathologic process starts in the muscles of eye motility...
November 11, 2016: International Ophthalmology
https://www.readbyqxmd.com/read/27831838/clinical-radiologic-correlation-of-extraocular-eye-movement-disorders-seeing-beneath-the-surface
#14
Joshua Thatcher, Yu-Ming Chang, Margaret N Chapman, Keegan Hovis, Akifumi Fujita, Rachel Sobel, Osamu Sakai
Extraocular eye movement disorders are relatively common and may be a significant source of discomfort and morbidity for patients. The presence of restricted eye movement can be detected clinically with quick, easily performed, noninvasive maneuvers that assess medial, lateral, upward, and downward gaze. However, detecting the presence of ocular dysmotility may not be sufficient to pinpoint the exact cause of eye restriction. Imaging plays an important role in excluding, in some cases, and detecting, in others, a specific cause responsible for the clinical presentation...
November 2016: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/27820875/improvement-of-eye-alignment-in-adult-strabismic-monkeys-by-sustained-igf-1-treatment
#15
Linda K McLoon, Stephen P Christiansen, Geoffrey M Ghose, Vallabh E Das, Michael J Mustari
Purpose: The goal of this study was to determine if continuous application of insulin-like growth factor-1 (IGF-1) could improve eye alignment of adult strabismic nonhuman primates and to assess possible mechanisms of effect. Methods: A continuous release pellet of IGF-1 was placed on one medial rectus muscle in two adult nonhuman primates (M1, M2) rendered exotropic by the alternating monocular occlusion method during the first months of life. Eye alignment and eye movements were recorded for 3 months, after which M1 was euthanized, and the lateral and medial rectus muscles were removed for morphometric analysis of fiber size, nerve, and neuromuscular density...
November 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27814312/impact-of-artifacts-on-vor-gain-measures-by-video-oculography-in-the-acute-vestibular-syndrome
#16
Georgios Mantokoudis, Ali S Saber Tehrani, Amy Wozniak, Karin Eibenberger, Jorge C Kattah, Cynthia I Guede, David S Zee, David E Newman-Toker
OBJECTIVE: The video head impulse test (HIT) measures vestibular function (vestibulo-ocular reflex [VOR] gain - ratio of eye to head movement), and, in principle, could be used to make a distinction between central and peripheral causes of vertigo. However, VOG recordings contain artifacts, so using unfiltered device data might bias the final diagnosis, limiting application in frontline healthcare settings such as the emergency department (ED). We sought to assess whether unfiltered data (containing artifacts) from a video-oculography (VOG) device have an impact on VOR gain measures in acute vestibular syndrome (AVS)...
November 3, 2016: Journal of Vestibular Research: Equilibrium & Orientation
https://www.readbyqxmd.com/read/27810558/single-ocular-injection-of-a-sustained-release-anti-vegf-delivers-6months-pharmacokinetics-and-efficacy-in-a-primate-laser-cnv-model
#17
Peter Adamson, Thomas Wilde, Eric Dobrzynski, Caroline Sychterz, Rodd Polsky, Edit Kurali, Richard Haworth, Chi-Man Tang, Justyna Korczynska, Fiona Cook, Irene Papanicolaou, Lemy Tsikna, Chris Roberts, Zoe Hughes-Thomas, James Walford, Daniel Gibson, John Warrack, Jos Smal, Ruud Verrijk, Paul E Miller, T Michael Nork, Jeffery Prusakiewicz, Timothy Streit, Steven Sorden, Craig Struble, Brian Christian, Ian R Catchpole
A potent anti-vascular endothelial growth factor (VEGF) biologic and a compatible delivery system were co-evaluated for protection against wet age-related macular degeneration (AMD) over a 6month period following a single intravitreal (IVT) injection. The anti-VEGF molecule is dimeric, containing two different anti-VEGF domain antibodies (dAb) attached to a human IgG1 Fc region: a dual dAb. The delivery system is based on microparticles of PolyActive™ hydrogel co-polymer. The molecule was evaluated both in vitro for potency against VEGF and in ocular VEGF-driven efficacy models in vivo...
November 1, 2016: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/27800278/orbital-metastasis-of-multiple-myeloma-case-report
#18
Mustafa Vatansever, Fatma Merve Bozkurt, Erdem Dinç, Eda Bengi Yılmaz, Erdinç Nayir, Ayşe Ayça Sarı, Özlem Yıldırım, Tuba Kara
A 68-year-old woman with a history of multiple myeloma presented to the clinic with pain and vision loss in her right eye. Proptosis was observed in her right eye and eye movements were restricted in all directions. Best corrected visual acuity was 3/10 in her right eye. On biomicroscopic examination, hyperemia and subconjunctival hemorrhage were present. Fundus examination of the right eye revealed optic disc edema and choroidal folds. In magnetic resonance imaging two orbital masses were detected. Based on the patient's history and ocular examination, we evaluated the masses as orbital metastasis of multiple myeloma...
June 2016: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/27789472/a-positive-vestibular-ocular-motor-screening-voms-is-associated-with-increased-recovery-time-after-sports-related-concussion-in-youth-and-adolescent-athletes
#19
Anthony J Anzalone, Damond Blueitt, Tami Case, Tiffany McGuffin, Kalyssa Pollard, J Craig Garrison, Margaret T Jones, Robert Pavur, Stephanie Turner, Jonathan M Oliver
BACKGROUND: Vestibular and ocular motor impairments are routinely reported in patients with sports-related concussion (SRC) and may result in delayed return to play (RTP). The Vestibular/Ocular Motor Screening (VOMS) assessment has been shown to be consistent and sensitive in identifying concussion when used as part of a comprehensive examination. To what extent these impairments or symptoms are associated with length of recovery is unknown. PURPOSE: To examine whether symptom provocation or clinical abnormality in specific domains of the VOMS results in protracted recovery (time from SRC to commencement of RTP protocol)...
October 27, 2016: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/27789358/lipid-nanoparticles-sln-nlc-overcoming-the-anatomical-and-physiological-barriers-of-the-eye-part-i-barriers-and-determining-factors-in-ocular-deliverybarriers-and-determining-factors-in-ocular-delivery
#20
E Sánchez-López, M Espina, S Doktorovova, E B Souto, M L García
Ocular drug delivery is still a challenge for researchers in the field of pharmaceutical technology due to anatomical and physiological eye characteristics. The tissue barriers (like as cornea, conjuntiva, blood aqueous barrier, and blood-retina barrier) limit the access of drugs to their targets. Taking into account the short retention time in the precorneal area of classical ocular dosage forms (e.g. solutions, suspensions or ointments) which are rapidly eliminated by tears and eyelid movement, only less than five per cent of the administered drug attains intraocular structures...
October 24, 2016: European Journal of Pharmaceutics and Biopharmaceutics
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