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https://www.readbyqxmd.com/read/29054113/post-operative-corticosteroid-irrigation-for-chronic-rhinosinusitis-after-endoscopic-sinus-surgery-a-meta-analysis
#1
Ho Young Yoon, Ho Seok Lee, In Hye Kim, Se Hwan Hwang
BACKGROUND: Recently, topical steroid therapy delivery using high-volume sinonasal irrigations has been used more frequently, following endoscopic sinus surgery (ESS), to improve drug delivery into the paranasal sinuses. OBJECTIVE: The goal of this study was to perform a systematic review with meta-analysis of the efficacy of steroid nasal irrigation on postoperative management of CRS following ESS. METHODS: Five databases (PubMed, SCOPUS, Embase, Web of Science, and the Cochrane database) from inception to March 2017 were independently reviewed by two researchers...
October 20, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/29054049/individual-variability-in-clinical-effect-and-tolerability-of-opioid-analgesics-importance-of-drug-interactions-and-pharmacogenetics
#2
REVIEW
Vigdis Solhaug, Espen Molden
BACKGROUND: As pain is often a comorbid condition, many patients use opioid analgesics in combination with several other drugs. This implies a generally increased risk of drug interactions, which along with inherent pharmacogenetic variability and other factors may cause differences in therapeutic response of opioids. AIM: To provide an overview of interactions and pharmacogenetic variability of relevance for individual differences in effect and tolerability of opioid analgesics, which physicians and other healthcare professionals should be aware of in clinical practice...
October 17, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29054047/application-of-transglycosylated-stevia-and-hesperidin-as-drug-carriers-to-enhance-biopharmaceutical-properties-of-poorly-soluble-artemisinin
#3
Kumaran Letchmanan, Shou-Cang Shen, Wai Kiong Ng, Reginald B H Tan
Biopharmaceutical properties of poorly water-soluble antimalarial drug, Artemisinin (ART), were improved by formulating amorphous solid dispersions with transglycosylated food additives (Hsp-G and Stevia-G) via co-spray drying. Both the formulated ART/Hsp-G and ART/Stevia-G showed superior dissolution properties with a burst release of more than 95% of drug within 5 min, whereas untreated ART dissolved only 4% in 5min. The supersaturation solubility of the formulated ART was enhanced by 2-fold as compared with untreated counterpart...
October 7, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29054046/surface-modification-of-polyisobutylene-via-grafting-amino-acid-based-poly-acryloyl-6-aminocaproic-acid-as-multifunctional-material
#4
Yanqiu Du, Chunming Li, Jing Jin, Chao Li, Wei Jiang
Amino acid-based P(acryloyl-6-aminocaproic acid) (PAACA) brushes were fabricated on polyisobutylene (PIB) surface combined with plasma pre-treatment and UV-induced grafting polymerization to construct an antifouling and functional material. The hydrophilicity and hemocompatibility of PIB were largely improved by surface modification of AACA, which were confirmed by water contact angle and platelet adhesion, respectively. PAACA brushes were precisely located onto the surface of PIB to create a patterned PIB-g-PAACA structure, and then the carboxyl groups on PAACA was activated to immobilize functional protein-Concanavalin A (Con A)...
October 12, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29053938/development-of-a-nanogel-based-nasal-vaccine-as-a-novel-antigen-delivery-system
#5
Rika Nakahashi-Ouchida, Yoshikazu Yuki, Hiroshi Kiyono
Nasal vaccination is one of the most effective immunization methods because it can induce effective antigen-specific immune responses not only at the mucosal site of administration but also at distant mucosal surfaces, as well as in the systemic compartment. Based on this advantage, many nasal vaccines are being developed and some have been licensed and marketed for clinical use. However, some have been withdrawn because of unacceptable adverse events such as inactivated influenza vaccine administrated with a heat-labile enterotoxin of Escherichia coli as an adjuvant...
October 20, 2017: Expert Review of Vaccines
https://www.readbyqxmd.com/read/29053764/contribution-of-calpain-and-caspases-to-cell-death-in-cultured-monkey-rpe-cells
#6
Emi Nakajima, Katherine B Hammond, Masayuki Hirata, Thomas R Shearer, Mitsuyoshi Azuma
Purpose: AMD is the leading cause of human vision loss after 65 years of age. Several mechanisms have been proposed: (1) age-related failure of the choroidal vasculature leads to loss of RPE; (2) RPE dysfunctions due to accumulation of phagocytized, but unreleased A2E (N-retinylidene-N-retinylethanolamine); (3) zinc deficiency activation of calpain and caspase proteases, leading to cell death. The purpose of the present study is to compare activation of calpain and caspase in monkey RPE cells cultured under hypoxia or with A2E...
October 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29053689/whole-cell-currents-induced-by-puff-application-of-gaba-in-brain-slices
#7
Yangjian Feng, Binliang Tang, Ming Chen, Li Yang
Pharmacological administration is commonly used when conducting whole-cell patch-clamp recording in brain slices. One of the best methods of drug application during electrophysiological recording is the puff technique, which can be used to study the effect of pharmacological reagents on neuronal activities in brain slices. The greatest advantage of puff application is that the drug concentration around the recording site increases rapidly, thus preventing desensitization of membrane receptors. Successful use of puff application involves careful attention to the following elements: the concentration of the drug, the parameters of the puff micropipette, the distance between the tip of a puff micropipette and the neuron recorded, and the duration and pressure driving the puff (pounds per square inch, psi)...
October 12, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29053584/lomefloxacin-induces-oxidative-stress-and-apoptosis-in-colo829-melanoma-cells
#8
Artur Beberok, Dorota Wrześniok, Martyna Szlachta, Jakub Rok, Zuzanna Rzepka, Michalina Respondek, Ewa Buszman
Although some fluoroquinolones have been found to exert anti-tumor activity, studies on the effect of these drugs on melanoma cells are relatively rare. The aim of this study was to examine the effect of lomefloxacin on cell viability, reactive oxygen species production, redox balance, cell cycle distribution, DNA fragmentation, and apoptosis in COLO829 melanoma cells. Lomefloxacin decreases the cell viability in a dose- and time-dependent manner. For COLO829 cells treated with the drug for 24, 48, and 72 h, the values of IC50 were found to be 0...
October 20, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29053577/electrographic-changes-accompanying-recurrent-seizures-under-ketogenic-diet-treatment
#9
Chiara Lucchi, Maddalena Marchiò, Elisa Caramaschi, Carmela Giordano, Rocco Giordano, Azzurra Guerra, Giuseppe Biagini
The ketogenic diet (KD) is increasingly used to treat epilepsy refractory to antiepileptic drugs and other neurological disorders. In animal models, the KD was found to increase the threshold to seizures induced by different convulsive stimulations. However, in models in which suprathreshold stimuli were used, a paradoxical seizure worsening was consistently observed in KD-fed animals. To better define this phenomenon, we characterized the electrographic response to seizures induced in mice which were treated with the KD, and then corneally stimulated at 6-Hz in four different sessions...
October 20, 2017: Pharmaceuticals
https://www.readbyqxmd.com/read/29053567/eco-friendly-formulated-zinc-oxide-nanoparticles-induction-of-cell-cycle-arrest-and-apoptosis-in-the-mcf-7-cancer-cell-line
#10
Amin Boroumand Moghaddam, Mona Moniri, Susan Azizi, Raha Abdul Rahim, Arbakariya Bin Ariff, Mohammad Navaderi, Rosfarizan Mohamad
Green products have strong potential in the discovery and development of unique drugs. Zinc oxide nanoparticles (ZnO NPs) have been observed to have powerful cytotoxicity against cells that cause breast cancer. The present study aims to examine the cell cycle profile, status of cell death, and pathways of apoptosis in breast cancer cells (MCF-7) treated with biosynthesized ZnO NPs. The anti-proliferative activity of ZnO NPs was determined using MTT assay. Cell cycle analysis and the mode of cell death were evaluated using a flow cytometry instrument...
October 20, 2017: Genes
https://www.readbyqxmd.com/read/29053518/role-of-homeodomain-interacting-protein-kinase-2-in-the-pathogenesis-of-tissue-fibrosis-in-keloid-derived-keratinocytes
#11
Yi-Xuan Zhao, Guo-You Zhang, An-Yuan Wang, Ya-Hong Chen, Da-Mu Lin, Qing-Feng Li
Epithelial-mesenchymal transition (EMT) plays a critical role in fibrotic keloid formation, which is characterized by excessive collagen and extracellular matrix synthesis and deposition. Growing evidence suggests that the serine/threonine kinase homeodomain-interacting protein kinase 2 (HIPK2) acts upstream of several major fibrosis signaling pathways; however, the role of HIPK2 in the keloid fibrogenesis remains unknown. In the current study, we investigated the roles of HIPK2 in the pathogenesis of keloids...
October 19, 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29053440/association-of-the-hla-b-alleles-with-carbamazepine-induced-stevens-johnson-syndrome-toxic-epidermal-necrolysis-in-the-javanese-and-sundanese-population-of-indonesia-the-important-role-of-the-hla-b75-serotype
#12
Rika Yuliwulandari, Erna Kristin, Kinasih Prayuni, Qomariyah Sachrowardi, Franciscus D Suyatna, Sri Linuwih Menaldi, Nuanjun Wichukchinda, Surakameth Mahasirimongkol, Larisa H Cavallari
Carbamazepine (CBZ) is a common cause of life-threatening cutaneous adverse drug reactions such as Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). Previous studies have reported a strong association between the HLA genotype and CBZ-induced SJS/TEN. We investigated the association between the HLA genotype and CBZ-induced SJS/TEN in Javanese and Sundanese patients in Indonesia. Nine unrelated patients with CBZ-induced SJS/TEN and 236 healthy Javanese and Sundanese controls were genotyped for HLA-B and their allele frequencies were compared...
October 20, 2017: Pharmacogenomics
https://www.readbyqxmd.com/read/29053415/low-concentration-of-5-fluorouracil-increases-the-effectiveness-of-tumor-rna-to-activate-murine-dendritic-cells
#13
Marcela Rodrigues de Camargo, Carolina Mendonça Gorgulho, Cecília Pessoa Rodrigues, Marcimara Penitenti, Juliana Cristina Longo Frederico, Maria Aparecida Marchesan Rodrigues, Ramon Kaneno
AIM: Considering the central role of dendritic cells (DCs) on the development of an antitumor immune response, in this study we used a murine model to evaluate how DC transfection with drug-treated tumor cell RNA changes their phenotype, and whether transfection enhances the in vivo effectiveness of a DC-based antitumor vaccine. MATERIALS AND METHODS: MC-38 colorectal tumor cells were pretreated with the minimum effective concentration of 5-fluorouracil (5-FU), then their total RNA was extracted and transfected into DCs...
October 2017: Cancer Biotherapy & Radiopharmaceuticals
https://www.readbyqxmd.com/read/29053388/some-chemotherapeutics-treated-colon-cancer-cells-display-a-specific-phenotype-being-a-combination-of-stem-like-and-senescent-cell-features
#14
H Was, J Czarnecka, A Kowalczyk, K Barszcz, T Bernas, K Piwocka, B Kaminska
Colorectal cancer (CRC) is the second leading cause of death among cancer patients in the Northern countries. CRC can reappear a long time after treatment. Recent clinical studies demonstrated that, in response to chemotherapy, cancer cells may undergo stress-induced premature senescence (SIPS), which typically results in growth arrest. Nonetheless, these senescent cells were reported to divide in an atypical manner and thus contribute to cancer re-growth. Therefore, we examined if SIPS escape may follow treatment with chemotherapeutics used clinically: 5-fluorouracil (5-FU), oxaliplatin (OXA) and irinotecan (IRINO)...
October 20, 2017: Cancer Biology & Therapy
https://www.readbyqxmd.com/read/29053281/insights-into-water-induced-phase-separation-in-itraconazole-hydroxypropylmethyl-cellulose-spin-coated-and-spray-dried-dispersions
#15
Naila A Mugheirbi, Patrick J Marsac, Lynne S Taylor
For amorphous solid dispersions, understanding the phase behavior of a given drug-polymer blend and factors that influence miscibility is crucial to design an optimally performing formulation. However, it can be challenging to fully map the phase behavior of some systems, especially those produced using a co-solvent system. In this study, a comprehensive investigation of phase separation in itraconazole-hydroxypropylmethylcellulose (ITZ-HPMC) blends fabricated using solvent evaporation processes, including spin coating and spray drying, has been carried out...
October 20, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29053217/behavioral-control-by-striatal-a2a-dopamine-d2-receptor-heteromers
#16
Jaume Taura, Marta Valle-León, Kristoffer Sahlholm, Masahiko Watanabe, Katheleen Van Craenenbroeck, Víctor Fernández-Dueñas, Sergi Ferré, Francisco Ciruela
G protein-coupled receptors (GPCR) exhibit the ability to form receptor complexes that include molecularly different GPCR (i.e. GPCR heteromers), which endow them with singular functional and pharmacological characteristics. The relative expression of GPCR heteromers remains a matter of intense debate. Recent studies support that adenosine A2A receptors (A2A R) and dopamine D2 receptors (D2 R) predominantly form A2A R-D2 R heteromers in the striatum. The aim of the present study was evaluating the behavioral effects of pharmacological manipulation and genetic blockade of A2A R and D2 R within the frame of such a predominant striatal heteromeric population...
October 20, 2017: Genes, Brain, and Behavior
https://www.readbyqxmd.com/read/29053192/dissociation-of-nnos-from-psd-95-promotes-functional-recovery-after-cerebral-ischaemia-in-mice-through-reducing-excessive-tonic-gaba-release-from-reactive-astrocytes
#17
Yu-Hui Lin, Hai-Ying Liang, Ke Xu, Huan-Yu Ni, Jian Dong, Hui Xiao, Lei Chang, Hai-Yin Wu, Fei Li, Dong-Ya Zhu, Chun-Xia Luo
Mechanisms underlying functional recovery after stroke are little known, and effective drug intervention during the delayed stage is desirable. One potential drug target, the protein-protein interaction between neuronal nitric oxide synthase (nNOS) and postsynaptic density protein 95 (PSD-95), is critical to acute ischaemic damage and neurogenesis. We show that nNOS-PSD-95 dissociation induced by microinjection of a recombinant fusion protein Tat-nNOS-N1-133 or systemic administration of a small molecule ZL006 from days 4 to 10 after photothrombotic ischaemia in mice reduced excessive tonic inhibition in the peri-infarct cortex and ameliorated motor functional outcome...
October 20, 2017: Journal of Pathology
https://www.readbyqxmd.com/read/29053140/measurement-of-bh3-only-protein-tolerance
#18
Haiming Dai, Husheng Ding, Kevin L Peterson, X Wei Meng, Paula A Schneider, Katherine L B Knorr, Scott H Kaufmann
The BCL2 family of proteins regulates cellular life and death decisions. Among BCL2 family members, BH3-only proteins have critical roles by neutralizing antiapoptotic family members, as well as directly activating BAX and BAK. Despite widespread occurrence of BH3-only protein upregulation in response to various stresses, this process is rarely quantified. Moreover, it is unclear whether all BH3-only proteins are equipotent at inducing cell death. Here we show that BH3-only proteins increase as much as 15- to 20-fold after various treatments and define a parameter, termed BH3-only tolerance, which measures how many copies of a particular BH3-only protein can be expressed before the majority of cells in a population undergo apoptosis...
October 20, 2017: Cell Death and Differentiation
https://www.readbyqxmd.com/read/29053122/-clinical-and-electromyography-characteristics-of-chemotherapy-induced-polyneuropathy
#19
N B Kholodova, Yu A Ponkratova, M V Sinkin
AIM: The study aimed at determining clinical and electromyography characteristics and developing the methods of CIPN treatment. MATERIAL AND METHODS: A clinical and electromyographic examinations and treatment of 30 with CIPN symptoms developed after polychemotherapy were performed. The authors developed treatment schemes included allopathic, homeopathic drugs, hydrotherapy and pharmacopuncture. RESULTS AND CONCLUSION: Most of the patients were diagnosed with axonal polyneuropathy with affection of long nerves of the limbs, some patients had a combination of axonopathy with myelopathy...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/29053080/aerosolizing-lipid-dispersions-enables-antibiotic-transport-across-mimics-of-the-lung-airway-surface-even-in-the-presence-of-pre-existing-lipid-monolayers
#20
Steven V Iasella, Amy Z Stetten, Timothy E Corcoran, Stephen Garoff, Todd M Przybycien, Robert D Tilton
BACKGROUND: Secondary lung infections are the primary cause of morbidity associated with cystic fibrosis lung disease. Aerosolized antibiotic inhalation is potentially advantageous but has limited effectiveness due to altered airway aerodynamics and deposition patterns that limit drug access to infected regions. One potential strategy to better reach infected areas is to formulate aerosols with surfactants that induce surface tension gradients and drive postdeposition drug dispersal via Marangoni transport along the airway surface liquid (ASL)...
October 20, 2017: Journal of Aerosol Medicine and Pulmonary Drug Delivery
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