keyword
MENU ▼
Read by QxMD icon Read
search

Drug induced

keyword
https://www.readbyqxmd.com/read/28830014/ultradeep-sequencing-of-b-and-non-b-hiv-1-subtypes-viral-diversity-and-drug-resistance-mutations-before-and-after-one-month-of-antiretroviral-therapy-in-naive-patients
#1
Olivier Epaulard, Anne Signori-Schmuck, Sylvie Larrat, Om Kulkarni, Michael G Blum, Katia Fusillier, Myriam Blanc, Pascale Leclercq, Olivier François, Patrice Morand
BACKGROUND: Ultradeep pyrosequencing technologies permit an assessment of the genetic diversity and the presence and frequency of minority variants in a viral population. The effect of these parameters on the outcome of highly active antiretroviral therapy (HAART) in HIV-infected patients is poorly understood. OBJECTIVES: The present study used the pyrosequencing Roche 454 prototype assay to determine whether antiretroviral efficacy is correlated with viral diversity and minority drug resistance mutations in HIV-infected treatment-naive patients and to compare assay performance in B and non-B subtypes...
July 25, 2017: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/28829835/exogenous-growth-factors-bfgf-egf-and-hgf-do-not-influence-viability-and-phenotype-of-v600ebraf-melanoma-cells-and-their-response-to-vemurafenib-and-trametinib-in-vitro
#2
Izabela Zalesna, Marta Osrodek, Mariusz L Hartman, Michal Rozanski, Malgorzata Sztiller-Sikorska, Karolina Niewinna, Dariusz Nejc, Malgorzata Czyz
It has been shown that the response of V600EBRAF melanoma cells to targeted therapeutics is affected by growth factors. We have investigated the influence of three different growth factors, bFGF, EGF and HGF used either alone or in combination, on the response of V600EBRAF melanoma cell populations established from surgical specimens to vemurafenib and trametinib, targeting V600EBRAF and MEK1/2, respectively. We report that proliferation and phenotype of V600EBRAF melanoma cell populations were not detectably influenced by exogenous growth factors...
2017: PloS One
https://www.readbyqxmd.com/read/28829785/dendrimer-doxorubicin-conjugates-exhibit-improved-anticancer-activity-and-reduce-doxorubicin-induced-cardiotoxicity-in-a-murine-hepatocellular-carcinoma-model
#3
Sibu P Kuruvilla, Gopinath Tiruchinapally, A Colleen Crouch, Mohamed E H ElSayed, Joan M Greve
Hepatocellular carcinoma (HCC) is the 2nd leading cause of cancer-related deaths every year globally. The most common form of treatment, hepatic arterial infusion (HAI), involves the direct injection of doxorubicin (DOX) into the hepatic artery. It is plagued with limited therapeutic efficacy and the occurrence of severe toxicities (e.g. cardiotoxicity). We aim to improve the therapeutic index of DOX delivered via HAI by loading the drug onto generation 5 (G5) poly(amidoamine) (PAMAM) dendrimers targeted to hepatic cancer cells via N-acetylgalactosamine (NAcGal) ligands...
2017: PloS One
https://www.readbyqxmd.com/read/28829771/mitochondria-and-lipid-raft-located-fof1-atp-synthase-as-major-therapeutic-targets-in-the-antileishmanial-and-anticancer-activities-of-ether-lipid-edelfosine
#4
Janny A Villa-Pulgarín, Consuelo Gajate, Javier Botet, Alberto Jimenez, Nicole Justies, Rubén E Varela-M, Álvaro Cuesta-Marbán, Ingrid Müller, Manuel Modolell, José L Revuelta, Faustino Mollinedo
BACKGROUND: Leishmaniasis is the world's second deadliest parasitic disease after malaria, and current treatment of the different forms of this disease is far from satisfactory. Alkylphospholipid analogs (APLs) are a family of anticancer drugs that show antileishmanial activity, including the first oral drug (miltefosine) for leishmaniasis and drugs in preclinical/clinical oncology trials, but their precise mechanism of action remains to be elucidated. METHODOLOGY/PRINCIPAL FINDINGS: Here we show that the tumor cell apoptosis-inducer edelfosine was the most effective APL, as compared to miltefosine, perifosine and erucylphosphocholine, in killing Leishmania spp...
August 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28829489/down-regulation-of-survivin-enhances-paclitaxel-induced-hela-cell-apoptosis
#5
F Gu, L Li, Q-F Yuan, C Li, Z-H Li
OBJECTIVE: Paclitaxel is one of the common anticancer drugs in the treatment of cervical cancer, while the mechanism of restraining and killing cancer cells is still unclear. This study aimed to investigate the molecular mechanism of paclitaxel in regulating proliferation and apoptosis of cervical cancer Hela cells. MATERIALS AND METHODS: Paclitaxel at 2 μmol/L was used to treat Hela cells for 48 h. MTT assay and flow cytometry were applied to test Hela cells proliferation and apoptosis respectively...
August 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28829429/establishing-dual-resistance-to-egfr-tki-and-met-tki-in-lung-adenocarcinoma-cells-in-vitro-with-a-2-step-dose-escalation-procedure
#6
Toshimitsu Yamaoka, Motoi Ohba, Satoru Arata, Tohru Ohmori
Drug resistance is a major challenge in cancer therapy. The generation of resistant sublines in vitro is necessary for discovering novel mechanisms to overcome this challenge. Here, a 2-step dose-escalation method for establishing dual-resistance to an epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor (TKI), gefitinib, and a MET-TKI, PHA665752, is described. This method is based on simple stepwise dose-escalation of inhibitors for inducing acquired resistance in cell lines. The alternate method for generating resistant sublines involves exposing the cells to high concentrations of the inhibitor in one step...
August 11, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28829421/electroconvulsive-seizures-in-rats-and-fractionation-of-their-hippocampi-to-examine-seizure-induced-changes-in-postsynaptic-density-proteins
#7
Sung-Soo Jang, Han Gil Jeong, Hee Jung Chung
Electroconvulsive seizure (ECS) is an experimental animal model of electroconvulsive therapy, the most effective treatment for severe depression. ECS induces generalized tonic-clonic seizures with low mortality and neuronal death and is a widely-used model to screen anti-epileptic drugs. Here, we describe an ECS induction method in which a brief 55-mA current is delivered for 0.5 s to male rats 200 - 250 g in weight via ear-clip electrodes. Such bilateral stimulation produced stage 4 - 5 clonic seizures that lasted about 10 s...
August 15, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28829355/the-herbal-bitter-drug-gentiana-lutea-modulates-lipid-synthesis-in-human-keratinocytes-in-vitro-and-in-vivo
#8
Ute Wölfle, Birgit Haarhaus, Jasmin Seiwerth, Anja Cawelius, Kay Schwabe, Karl-Werner Quirin, Christoph M Schempp
Gentiana lutea is a herbal bitter drug that is used to enhance gastrointestinal motility and secretion. Recently we have shown that amarogentin, a characteristic bitter compound of Gentiana lutea extract (GE), binds to the bitter taste receptors TAS2R1 and TAS2R38 in human keratinocytes, and stimulates the synthesis of epidermal barrier proteins. Here, we wondered if GE also modulates lipid synthesis in human keratinocytes. To address this issue, human primary keratinocytes were incubated for 6 days with GE...
August 22, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28829237/comparative-ultrastructural-hepatic-alterations-induced-by-free-and-liposome-encapsulated-mefenamic-acid
#9
Qais Bashir Jarrar, Muhammad Nazrul Hakim, Manraj Singh Cheema, Zainul Amiruddin Zakaria
Mefenamic acid (MFA) is used as an anti-inflammatory, antinociceptive, and antipyretic agent for treatment of a wide range of pathological disorders. While the uncertainty of its safety and the poor oral bioavailability constitute the major limiting factors of its medical use, considerable efforts including liposomal encapsulation are needed to achieve maximum therapeutic advantages. The current work was conducted to investigate the ultrastructural alterations in the liver induced by free MFA and its liposomal preparation...
September 2017: Ultrastructural Pathology
https://www.readbyqxmd.com/read/28829209/the-effect-of-sglt2-inhibitors-on-cardiovascular-events-and-renal-function
#10
Konstantinos P Imprialos, Konstantinos Stavropoulos, Michael Doumas, Asterios Karagiannis, Vasilios G Athyros
Introduction Sodium-glucose co-transporters-2inhibitors have emerged as a very promising antidiabetic drug class, with data from the two available cardiovascular trials of this class suggesting remarkable benefits in terms of cardiovascular events, total mortality and renal outcomes. Areas covered Data point toward clinically meaningful benefits from SGLT-2inhibition on a variety of cardiovascular risk factors. Empagliflozin, and to a lesser extent canagliflozin, resulted in significant reductions of an abundance of cardiovascular mortality and morbidity endpoints...
August 22, 2017: Expert Review of Clinical Pharmacology
https://www.readbyqxmd.com/read/28828983/epigenetics-of-virus-induced-tumors-perspectives-for-therapeutic-targeting
#11
Svetlana Vinokurova
About 15-20% of human cancers worldwide have viral etiology. Seven human DNA and RNA viruses are accepted to be oncogenic viruses or oncoviruses and contribute to the development of various cancer types. Human oncoviruses have developed multiple molecular mechanisms to interfere with specific cellular pathways to promote viral replication and viral life cycle maintenance in the host. Despite the diversity of oncogenic viruses, they use similar strategies for cancer development. Viral oncoproteins and viral non-coding RNAs are the key factors that can affect multiple cellular processes on both genetic and epigenetic levels...
August 21, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28828982/development-of-benzimidazole-derivatives-as-novel-anti-platelet-drugs
#12
Wei-Cheng Yao, Lan-Ting Yuan, Wen-Bin Yang, Chih-Hsuan Hsia, Li-Ting Huang, Tzu-Yin Lee, Joen-Rong Sheu, Wan-Jung Lu, Thanasekaran Jayakumar, Ray-Jade Chen
BACKGROUND: Benzimidazoles are privileged biomolecules which form an integral part of vitamin B12 and have been attracting numerous researchers all over the world to assess their potential therapeutic significance. OBJECTIVES: The comparative in vitro antiplatelet activity of newly synthesized benzimidazole derivatives, M3BIM, C2BIM, and L2BIM in thrombin, adenosine diphosphate (ADP) and epinephrine-induced washed human platelets was investigated. METHODS: Reversed-phase silica gel column chromatography, Aggregometry, Flow cytometry and Immunoblotting were used in this study...
August 20, 2017: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/28828709/a-comprehensive-review-on-pharmacotherapeutics-of-three-phytochemicals-curcumin-quercetin-and-allicin-in-the-treatment-of-gastric-cancer
#13
REVIEW
Atousa Haghi, Haniye Azimi, Roja Rahimi
OBJECTIVE: Gastric cancer is one of the most common causes of cancer-related death worldwide. Medicinal plants are one of the main sources for discovery of new pharmacological agents especially for treatment of cancers. The aim of the present study is to review pharmacotherapeutic aspects of three mostly studied phytochemicals including curcumin, quercetin, and allicin for management of gastric cancer. METHODS: Scopus, PubMed, Web of Science, and Google Scholar were searched for the effects of curcumin, quercetin, allicin, and their analogs in gastric cancer...
August 22, 2017: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/28828705/glucotoxicity-promotes-aberrant-activation-and-mislocalization-of-ras-related-c3-botulinum-toxin-substrate-1-rac1-and-metabolic-dysfunction-in-pancreatic-islet-%C3%AE-cells-reversal-of-such-metabolic-defects-by-metformin
#14
Sartaj Baidwan, Anil Chekuri, DiAnna L Hynds, Anjaneyulu Kowluru
Emerging evidence suggests that long-term exposure of insulin-secreting pancreatic β-cells to hyperglycemic (HG; glucotoxic) conditions promotes oxidative stress, which, in turn, leads to stress kinase activation, mitochondrial dysfunction, loss of nuclear structure and integrity and cell apoptosis. Original observations from our laboratory have proposed that Rac1 plays a key regulatory role in the generation of oxidative stress and downstream signaling events culminating in the onset of dysfunction of pancreatic β-cells under the duress of metabolic stress...
August 21, 2017: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/28828622/modafinil-attenuates-inflammation-via-inhibiting-akt-nf-%C3%AE%C2%BAb-pathway-in-apoe-deficient-mouse-model-of-atherosclerosis
#15
Jinxia Han, Dongwei Chen, Dayi Liu, Yanan Zhu
Modafinil, an FDA approved wakefulness drug prescribed to narcolepsy patients, has recently been shown to have anti-inflammatory effects and provides protection against neuroinflammation. It is unknown if modafinil can also protect against atherosclerosis, pathogenesis of which implicates inflammation. Using an apoE-deficient mouse model, we tried to elucidate the effects of modafinil treatment on the development of atherosclerosis. We tested serum levels of cytokines. We isolated mouse bone marrow-derived macrophages (BMDMs), detected effect of modafinil on the viability and proliferation of BMDMs, and on oxidized low-density lipoprotein-induced IL-6 and TNF-α, and supernatant level of IFN-γ as well as NF-κB activity in BMDMs...
August 21, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/28828613/glutamate-transport-system-as-a-novel-therapeutic-target-in-chronic-pain-molecular-mechanisms-and-pharmacology
#16
Georgi Gegelashvili, Ole Jannik Bjerrum
The vast majority of peripheral neurons sensing noxious stimuli and conducting pain signals to the dorsal horn of the spinal cord utilize glutamate as a chemical transmitter of excitation. High-affinity glutamate transporter subtypes GLAST/EAAT1, GLT1/EAAT2, EAAC1/EAAT3, and EAAT4, differentially expressed on sensory neurons, postsynaptic spinal interneurons, and neighboring glia, ensure fine modulation of glutamate neurotransmission in the spinal cord. The glutamate transport system seems to play important roles in molecular mechanisms underlying chronic pain and analgesia...
2017: Advances in Neurobiology
https://www.readbyqxmd.com/read/28828580/formulation-and-in-vitro-release-kinetics-of-mucoadhesive-blend-gels-containing-matrine-for-buccal-administration
#17
Xiaojin Chen, Jun Yan, Shuying Yu, Pingping Wang
Enterovirus 71 (EV71) is a pathogenic factor of severe hand, foot, and mouth disease (HFMD). No vaccine or specific treatment is currently available for EV71 infection. Hence, we developed a buccal mucoadhesive gel containing matrine to protect against HFMD. Mucoadhesive gels were prepared by Carbopol 974P and were combined with Carbopol 971P, sodium carboxymethyl cellulose (CMC-Na), or hydroxypropylmethy cellulose (HPMC K100M). The formulations were characterized in terms of tensile testing and continuous flow techniques for mucoadhesion...
August 21, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/28828418/the-anti-obesity-properties-of-the-proanthocyanidin-extract-from-the-leaves-of-chinese-bayberry-myrica-rubra-sieb-et-zucc
#18
Xiaozhou Zhou, Shiguo Chen, Xingqian Ye
The anti-obesity effects of different proanthocyanidin extracts (PE) from Chinese bayberry (Myrica rubra Sieb.et Zucc.) leaves were evaluated in a high-fat (HF) diet-induced obese rat model. The leaves of Chinese bayberry (LCB), a non-desaccharified proanthocyanidin extract (NDPE), and a desaccharified proanthocyanidin extract (DPE) were compared with orlistat, a conventional anti-obesity drug used as a positive control. The rats from all of the PE-treated groups showed obvious weight loss, with the greatest weight loss in the DPE group (P < 0...
August 22, 2017: Food & Function
https://www.readbyqxmd.com/read/28828347/the-role-of-gamma-amino-butyric-acid-in-cisplatin-induced-nephrotoxicity-in-streptozotocin-induced-diabetic-rats
#19
Masoomeh Nasiri, Nepton Soltani, Safoora Mazaheri, Maryam Maleki, Ardeshir Talebi, Fatemah Gharibi, Mehdi Nematbakhsh
BACKGROUND: Diabetes mellitus can change the risk of developing cancer. Cisplatin (CP) is a common antineoplastic drug. The major side effect of CP is nephrotoxicity. Gamma amino butyric acid (GABA) is an antioxidant agent that may have a protective role against CP-induced nephrotoxicity. The aim of the present study was to investigate the role of GABA in CP-induced nephrotoxicity in hyperglycemic male and female rats. MATERIALS AND METHODS: Sixty male and female Wistar diabetic rats were used in ten experimental groups...
2017: Advanced Biomedical Research
https://www.readbyqxmd.com/read/28828163/erythema-multiforme-induced-by-alendronate-sodium-in-a-geriatric-patient-a-case-report-and-review-of-the-literature
#20
José-Alcides de Arruda, Pedro Silva, Márcio-Bruno Amaral, Fernanda Cotta, Renata Avendanho, Ricardo Mesquita
Erythema multiforme is an uncommon acute inflammatory disorder caused by exposure to microbes or drugs. Erythema multiforme minor typically affects only one mucosa and can be associated with symmetrical target skin lesions on the extremities. The disease usually occurs in patients in their 3rd and 4th decade of life, but can also affect children and adolescents. Alendronate sodium has been approved for the prevention and treatment of osteoporosis in postmenopausal women, but is associated with adverse events...
July 2017: Journal of Clinical and Experimental Dentistry
keyword
keyword
10780
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"