Shin Yoo, Markus Rottmann, Jason Ng, David Johnson, Bassel Shanab, Anna Pfenniger, Gail Elizabeth Geist, Suman Mandava, Amy Burrell, Wenwei Zhang, J Andrew Wasserstrom, Bradley P Knight, Rod Passman, Jeffrey J Goldberger, Rishi Arora
Traditional anatomically guided ablation and attempts to perform electrogram-guided atrial fibrillation (AF) ablation (CFAE, DF, and FIRM) have not been shown to be sufficient treatment for persistent AF. Using biatrial high-density electrophysiologic mapping in a canine rapid atrial pacing model of AF, we systematically investigated the relationship of electrogram morphology recurrence (EMR) (Rec% and CLR ) with established AF electrogram parameters and tissue characteristics. Rec% correlates with stability of rotational activity and with the spatial distribution of parasympathetic nerve fibers...
January 2023: JACC. Basic to Translational Science