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https://www.readbyqxmd.com/read/28749549/a-double-blind-placebo-controlled-study-of-rituximab-in-patients-with-stiff-person-syndrome
#1
Marinos C Dalakas, Goran Rakocevic, James M Dambrosia, Harry Alexopoulos, Beverly McElroy
Objective In Stiff-Person Syndrome (SPS), an antibody-mediated impaired GABAergic neurotransmission is believed to cause muscle stiffness and spasms. Patients improve with GABA-enhancing drugs and IVIg, but several respond poorly and remain disabled. The need for more effective therapy prompted a trial with the anti-CD20 monoclonal antibody rituximab. Methods This was a placebo-controlled randomized trial of rituximab (two bi-weekly infusions of 1gr each). The primary outcome was a change in stiffness scores at 6 months...
July 27, 2017: Annals of Neurology
https://www.readbyqxmd.com/read/28749247/evaluating-the-effectiveness-of-a-community-based-hygiene-promotion-program-in-a-rural-salvadoran-setting
#2
Elizabeth L Andrade, Jeffrey B Bingenheimer, Mark C Edberg, Kathryn L Zoerhoff, Emily M Putzer
There has been considerable progress in the reduction of diarrheal disease among children under five through health and nutrition interventions. However, diarrheal disease is still the second leading cause of child death worldwide. There is growing recognition that comprehensive hygiene behavior improvements should be integral to prevention efforts, but the effectiveness of different approaches for hygiene promotion is still being established. Hygiene risk practices vary across settings, suggesting that prevention strategies should be adapted to local contexts using community-based approaches...
July 1, 2017: Global Health Promotion
https://www.readbyqxmd.com/read/28749228/-it-changed-everything-and-not-all-in-a-bad-way-reflections-of-pediatric-cancer-experiences
#3
Monica L Molinaro, Paula C Fletcher
Pediatric cancer, otherwise known as childhood cancer, is devastating to both children and their families. All individuals in a family are often physically, psychologically, and socially affected. Using the qualitative theoretical orientation of interpretive phenomenology, interviews were conducted with 10 pediatric cancer survivors and 9 of their support persons to gain a more holistic understanding of the pediatric cancer experiences of children and their families. A total of 4 themes emerged from the data, however only the past experiences of the survivors and their recollection of their pediatric journeys will be discussed...
September 2017: Compr Child Adolesc Nurs
https://www.readbyqxmd.com/read/28748738/barriers-and-facilitators-to-healthy-eating-and-disease-self-management-among-older-adults-residing-in-subsidized-housing
#4
Katherine Petroka, Rania Campbell-Bussiere, Dan K Dychtwald, Brandy-Joe Milliron
BACKGROUND: As adults transition into older ages, meeting age-specific dietary recommendations can become increasingly challenging, especially for low-income seniors who reside in publicly subsidized rental housing. AIM: The primary objectives of this study were to: 1) identify barriers and facilitators to healthy eating and self-management of nutrition-related chronic illnesses experienced by low-income seniors residing in a subsidized housing setting; and 2) assess the interest in community nutrition programming among low-income seniors residing in a subsidized housing setting...
January 1, 2017: Nutrition and Health
https://www.readbyqxmd.com/read/28748723/applying-positive-deviance-for-improving-compliance-to-adolescent-anemia-control-program-in-tribal-communities-of-india
#5
Vani Sethi, Monique Sternin, Deepika Sharma, Arti Bhanot, Saba Mebrahtu
BACKGROUND: Positive deviance (PD) is an asset-based social and behavior change communication strategy, utilizing successful outliers within a specific context. It has been applied to tackling major public health problems but not adolescent anemia. OBJECTIVE: The study, first of its kind, used PD to improve compliance to adolescent anemia control program in Jharkhand, India, where anemia prevalence in adolescent girls is 70%, and program compliance is low. METHODS: With leadership of state government, the study was designed and implemented by a multidisciplinary 42 member PD team, in Khunti district, in 2014...
January 1, 2017: Food and Nutrition Bulletin
https://www.readbyqxmd.com/read/28748709/aging-perceptions-in-older-gay-and-bisexual-men-in-portugal-a-qualitative-study
#6
Henrique Pereira, Juan Pedro Serrano, Brian de Vries, Graça Esgalhado, Rosa Marina Afonso, Samuel Monteiro
Aims and Objectives The purpose of this study was to explore the perceptions toward aging among Portuguese gay and bisexual men over 60 years old. Background Despite the growth of the older population, and the increased visibility and acceptance of lesbian, gay, and bisexual people in Western countries, the experience of aging in older gay and bisexual men is only beginning to be understood. Design We used a qualitative research methodology, based on critical gerontology, for establishing research questions and to identify the perspectives on the aging process in older gay and bisexual individuals...
January 1, 2017: International Journal of Aging & Human Development
https://www.readbyqxmd.com/read/28748625/multiple-risk-factor-counseling-to-promote-heart-healthy-lifestyles-in-the-chest-pain-observation-unit-pilot-randomized-controlled-trial
#7
David A Katz, Mark Graber, Patricia Lounsbury, Mark W Vander Weg, Emily K Phillips, Christina Clair, Phillip A Horwitz, Xueya Cai, Alan J Christensen
OBJECTIVE: Admission to the chest pain observation unit (CPOU) may be an advantageous time for patients to consider heart-healthy lifestyle changes while undergoing diagnostic evaluation to rule out myocardial ischemia. The aim of this pragmatic trial was to assess the effectiveness of a multiple risk factor intervention in changing CPOU patients' health beliefs and readiness to change health behaviors. A secondary aim was to obtain preliminary estimates of the intervention's effect on diet, physical activity, and smoking...
July 27, 2017: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/28748608/four-years-comparative-follow-up-evaluation-of-community-based-step-down-and-residential-specialist-psychodynamic-programmes-for-personality-disorders
#8
Marco Chiesa, Antonella Cirasola, Peter Fonagy
Although the fulcrum of service provision for personality disorder (PD) has shifted from hospital-based to psychodynamically- and cognitively-oriented outpatient programmes, very few studies have attempted to compare specialist moderate intensity outpatient programmes with specialist high-intensity residential models, or to explore whether a period of inpatient treatment may be necessary to improve outcome and prognosis. In this article, we prospectively compare changes over a 4-year period in 3 groups of patients with personality disorders (N = 162) treated in a specialist community-based (CBP, N = 30), a step-down (RT-CBP, N = 87), and a specialist residential programme (RT, N = 45) in psychiatric distress, deliberate self-injury, and suicide attempt using multilevel modelling and multivariate logistic regression analyses...
July 26, 2017: Clinical Psychology & Psychotherapy
https://www.readbyqxmd.com/read/28748391/social-capital-dynamics-and-health-in-mid-to-later-life-findings-from-australia
#9
Vasoontara Yiengprugsawan, Jennifer Welsh, Hal Kendig
PURPOSE: The influence of social capital has been shown to improve health and wellbeing. This study investigates the relationship between changes in social capital and health outcomes during a 6-year follow-up in mid to later life in Australia. METHODS: Nationally representative data from the Household, Income and Labour Dynamics in Australia (HILDA) survey included participants aged 45 years and over who responded in 2006, 2010 and 2012 (N = 3606). Each of the three components of social capital (connectedness, trust and participation) was measured in Waves 2006 and 2010 and categorised as: 'never low', 'transitioned to low', 'transitioned out of low' and 'consistently low'...
July 26, 2017: Quality of Life Research
https://www.readbyqxmd.com/read/28748384/the-more-vivid-the-imagination-the-better-the-role-of-the-vividness-of-imagination-in-vasoconstriction-training-and-vasodilatation-training
#10
Julia E Graef, Winfried Rief, Yvonne Nestoriuc, Cornelia Weise
Blood volume pulse biofeedback represents an effective non-pharmacological treatment for migraine. However, the underlying mechanisms of blood volume pulse biofeedback are still unclear. This study investigated the influence of vividness of imagination, private body consciousness, perfectionism, and general self-efficacy on physiological (blood volume pulse amplitude) and psychological (session performance rated by participants and by trainers) success. Changes in skin conductance and skin temperature indicating habituation to training context were examined...
July 26, 2017: Applied Psychophysiology and Biofeedback
https://www.readbyqxmd.com/read/28747999/human-immunodeficiency-virus-care-cascade-among-sub-populations-in-rakai-uganda-an-observational-study
#11
Veena G Billioux, Larry W Chang, Steven J Reynolds, Gertrude Nakigozi, Joseph Ssekasanvu, Mary K Grabowski, Robert Ssekubugu, Fred Nalugoda, Godfrey Kigozi, Joseph Kagaayi, David Serwadda, Ronald H Gray, Maria J Wawer
Introduction: To assess progress towards the UNAIDS 90-90-90 initiative targets, we examined the HIV care cascade in the population-based Rakai Community Cohort Study (RCCS) in rural Uganda and examined differences between sub-groups. Methods: Self-reports and clinical records were used to assess the proportion achieving each stage in the cascade. Statistical inference based on a χ(2) test for categorical variables and modified Poisson regression were used to estimate prevalence risk ratios (PRRs) and 95% confidence intervals (CI) for enrolment into care and initiating antiretroviral therapy (ART)...
2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28747703/linking-the-morphological-and-metabolomic-response-of-lactuca-sativa-l-exposed-to-emerging-contaminants-using-gc%C3%A2-%C3%A3-%C3%A2-gc-ms-and-chemometric-tools
#12
Carlos Hurtado, Hadi Parastar, Víctor Matamoros, Benjamín Piña, Romà Tauler, Josep M Bayona
The occurrence of contaminants of emerging concern (CECs) in irrigation waters (up to low μg L(-1)) and irrigated crops (ng g(-1) in dry weight) has been reported, but the linkage between plant morphological changes and plant metabolomic response has not yet been addressed. In this study, a non-targeted metabolomic analysis was performed on lettuce (Lactuca sativa L) exposed to 11 CECs (pharmaceuticals, personal care products, anticorrosive agents and surfactants) by irrigation. The plants were watered with different CEC concentrations (0-50 µg L(-1)) for 34 days under controlled conditions and then harvested, extracted, derivatised and analysed by comprehensive two-dimensional gas chromatography coupled to a time-of-flight mass spectrometer (GC × GC-TOFMS)...
July 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28747397/changes-and-classification-in-myocardial-contractile-function-in-the-left-ventricle-following-acute-myocardial-infarction
#13
Hao Gao, Andrej Aderhold, Kenneth Mangion, Xiaoyu Luo, Dirk Husmeier, Colin Berry
In this research, we hypothesized that novel biomechanical parameters are discriminative in patients following acute ST-segment elevation myocardial infarction (STEMI). To identify these biomechanical biomarkers and bring computational biomechanics 'closer to the clinic', we applied state-of-the-art multiphysics cardiac modelling combined with advanced machine learning and multivariate statistical inference to a clinical database of myocardial infarction. We obtained data from 11 STEMI patients (ClinicalTrials...
July 2017: Journal of the Royal Society, Interface
https://www.readbyqxmd.com/read/28747321/the-affordable-care-act-reduced-socioeconomic-disparities-in-health-care-access
#14
Kevin Griffith, Leigh Evans, Jacob Bor
The United States has the largest socioeconomic disparities in health care access of any wealthy country. We assessed changes in these disparities in the United States under the Affordable Care Act (ACA). We used survey data for the period 2011-15 from the Behavioral Risk Factor Surveillance System to assess trends in insurance coverage, having a personal doctor, and avoiding medical care due to cost. All analyses were stratified by household income, education level, employment status, and home ownership status...
July 26, 2017: Health Affairs
https://www.readbyqxmd.com/read/28747295/motivate-a-pretreatment-web-based-program-to-improve-attendance-at-uk-outpatient-services-among-adults-with-eating-disorders
#15
Sarah Muir, Ciarán Newell, Jess Griffiths, Kathy Walker, Holly Hooper, Sarah Thomas, Peter W Thomas, Jon Arcelus, James Day, Katherine M Appleton
BACKGROUND: In the UK, eating disorders affect upward of 725,000 people per year, and early assessment and treatment are important for patient outcomes. Around a third of adult outpatients in the UK who are referred to specialist eating disorder services do not attend, which could be related to patient factors related to ambivalence, fear, and a lack of confidence about change. This lack of engagement has a negative impact on the quality of life of patients and has implications for service costs...
July 26, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28747279/portable-objective-assessment-of-upper-extremity-motor-function-in-parkinson-s-disease
#16
L M Chahine, L Uribe, P Hogarth, J McNames, A Siderowf, K Marek, D Jennings
INTRODUCTION: Objective, portable measures of motor function for out-of-office assessments are needed in Parkinson's Disease (PD). This study had 3 objectives. First, to examine change in objective motor measurements in PD (as assessed with the Objective PD Measurement (OPDM) system). Second, to correlate objective measures with clinical features and putative PD cerebrospinal fluid (CSF) and dopaminergic imaging biomarkers. Third, to assess participant compliance with and perceptions of serial in-home motor assessments...
July 19, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28747274/efficacy-safety-and-effect-on-sexual-behaviour-of-on-demand-pre-exposure-prophylaxis-for-hiv-in-men-who-have-sex-with-men-an-observational-cohort-study
#17
Jean-Michel Molina, Isabelle Charreau, Bruno Spire, Laurent Cotte, Julie Chas, Catherine Capitant, Cecile Tremblay, Daniela Rojas-Castro, Eric Cua, Armelle Pasquet, Camille Bernaud, Claire Pintado, Constance Delaugerre, Luis Sagaon-Teyssier, Soizic Le Mestre, Christian Chidiac, Gilles Pialoux, Diane Ponscarme, Julien Fonsart, David Thompson, Mark A Wainberg, Veronique Doré, Laurence Meyer
BACKGROUND: Data for on-demand pre-exposure prophylaxis (PrEP) are scarce. We implemented a cohort study to assess its efficacy, safety, and effect on sexual behaviour. METHODS: We invited men and transgender women who have sex with men, previously enrolled in the randomised placebo-controlled ANRS IPERGAY trial at seven sites (six in France and one in Canada), to participate in an open-label extension with on-demand tenofovir disoproxil fumarate (300 mg) and emtricitabine (200 mg) to be taken before and after sexual intercourse...
July 21, 2017: Lancet HIV
https://www.readbyqxmd.com/read/28747207/lessons-learnt-from-the-magnet-malawian-german-hospital-partnership-the-german-perspective-on-contributions-to-patient-care-and-capacity-development
#18
Florian Neuhann, Sandra Barteit
BACKGROUND: Malawi is a low-income country with one of the highest HIV prevalence rates worldwide (Kendig et al., Trop Med Health 41:163-170, 2013). The health system depends largely on external funding. Official German development aid has supported health care in Malawi for many years (German Embassy Lilongwe, The German Development Cooperation in Malawi), including placing medical doctors in various departments of the Kamuzu Central Hospital (KCH) in Lilongwe. In 2008, a hospital partnership called MAGNET (Malawi German Networking for Capacity Building in Treatment, Training and Research at KCH) evolved as part of the German ESTHER network...
July 26, 2017: Globalization and Health
https://www.readbyqxmd.com/read/28747154/the-interplay-between-individual-social-behavior-and-clinical-symptoms-in-small-clustered-groups
#19
Piero Poletti, Roberto Visintainer, Bruno Lepri, Stefano Merler
BACKGROUND: Mixing patterns of human populations play a crucial role in shaping the spreading paths of infectious diseases. The diffusion of mobile and wearable devices able to record close proximity interactions represents a great opportunity for gathering detailed data on social interactions and mixing patterns in human populations. The aim of this study is to investigate how social interactions are affected by the onset of symptomatic conditions and to what extent the heterogeneity in human behavior can reflect a different risk of infection...
July 26, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28746709/association-of-coronary-artery-calcium-score-vs-age-with-cardiovascular-risk-in-older-adults-an-analysis-of-pooled-population-based-studies
#20
Yuichiro Yano, Christopher J O'Donnell, Lewis Kuller, Maryam Kavousi, Raimund Erbel, Hongyan Ning, Ralph D'Agostino, Anne B Newman, Khurram Nasir, Albert Hofman, Nils Lehmann, Klodian Dhana, Ron Blankstein, Udo Hoffmann, Stefan Möhlenkamp, Joseph M Massaro, Amir-Abbas Mahabadi, Joao A C Lima, M Arfan Ikram, Karl-Heinz Jöckel, Oscar H Franco, Kiang Liu, Donald Lloyd-Jones, Philip Greenland
Importance: Besides age, other discriminators of atherosclerotic cardiovascular disease (ASCVD) risk are needed in older adults. Objectives: To examine the predictive ability of coronary artery calcium (CAC) score vs age for incident ASCVD and how risk prediction changes by adding CAC score and removing only age from prediction models. Design, Setting, and Participants: We conducted an analysis of pooled US population-based studies, including the Framingham Heart Study, the Multi-Ethnic Study of Atherosclerosis, and the Cardiovascular Health Study...
July 26, 2017: JAMA Cardiology
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