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https://www.readbyqxmd.com/read/28490306/adherence-to-diabetic-eye-examination-guidelines-in-australia-the-national-eye-health-survey
#1
Joshua Foreman, Stuart Keel, Jing Xie, Peter Van Wijngaarden, Hugh R Taylor, Mohamed Dirani
OBJECTIVE: To determine adherence to NHMRC eye examination guidelines for Indigenous and non-Indigenous Australian people with diabetes. DESIGN: Cross-sectional survey using multistage, random cluster sampling. SETTING: Thirty randomly selected geographic sites in the five mainland Australian states and the Northern Territory, stratified by remoteness. PARTICIPANTS: 1738 Indigenous Australians aged 40-92 years and 3098 non-Indigenous Australians aged 50-98 years were recruited and examined between March 2015 and April 2016 according to a standardised protocol that included a questionnaire (administered by an interviewer) and a series of standard eye tests...
May 15, 2017: Medical Journal of Australia
https://www.readbyqxmd.com/read/28333279/inhibition-of-pim1-kinase-attenuates-inflammation-induced-pro-labour-mediators-in-human-fetal-membranes-in-vitro
#2
Ratana Lim, Gillian Barker, Martha Lappas
STUDY QUESTION: Does proviral integration site for Moloney murine leukemic virus (PIM)1 kinase play a role in regulating the inflammatory processes of human labour and delivery? SUMMARY ANSWER: PIM1 kinase plays a critical role in fetal membranes in regulating pro-inflammatory and pro-labour mediators. WHAT IS KNOWN ALREADY: Infection and inflammation have strong causal links to preterm delivery by stimulating pro-inflammatory cytokines and collagen degrading enzymes, which can lead to rupture of membranes...
March 9, 2017: Molecular Human Reproduction
https://www.readbyqxmd.com/read/28333195/genome-wide-genetic-analyses-highlight-mitogen-activated-protein-kinase-mapk-signaling-in-the-pathogenesis-of-endometriosis
#3
Outi Uimari, Nilufer Rahmioglu, Dale R Nyholt, Katy Vincent, Stacey A Missmer, Christian Becker, Andrew P Morris, Grant W Montgomery, Krina T Zondervan
STUDY QUESTION: Do genome-wide association study (GWAS) data for endometriosis provide insight into novel biological pathways associated with its pathogenesis? SUMMARY ANSWER: GWAS analysis uncovered multiple pathways that are statistically enriched for genetic association signals, analysis of Stage A disease highlighted a novel variant in MAP3K4, while top pathways significantly associated with all endometriosis and Stage A disease included several mitogen-activated protein kinase (MAPK)-related pathways...
April 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28333180/influence-of-the-disease-label-polycystic-ovary-syndrome-on-intention-to-have-an-ultrasound-and-psychosocial-outcomes-a-randomised-online-study-in-young-women
#4
Tessa Copp, Kirsten McCaffery, Lamiae Azizi, Jenny Doust, Ben W J Mol, Jesse Jansen
STUDY QUESTION: Does the disease label 'polycystic ovary syndrome' (PCOS) have an impact on desire for medical testing and psychosocial outcomes? SUMMARY ANSWER: When given the disease label PCOS in a hypothetical scenario, participants had higher intention to have an ultrasound, perceived the condition to be more severe and had lower self-esteem than those not given the disease label. WHAT IS KNOWN ALREADY: Widening diagnostic criteria and improved imaging sensitivity have increased the number of reproductive-aged women diagnosed with PCOS from 4% to 8% to up to 21%...
April 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28314746/protocol-for-a-cluster-randomised-stepped-wedge-trial-assessing-the-impact-of-a-community-level-hygiene-intervention-and-a-water-intervention-using-riverbank-filtration-technology-on-diarrhoeal-prevalence-in-india
#5
Sarah L McGuinness, Joanne E O'Toole, Thomas B Boving, Andrew B Forbes, Martha Sinclair, Sumit K Gautam, Karin Leder
INTRODUCTION: Diarrhoea is a leading cause of death globally, mostly occurring as a result of insufficient or unsafe water supplies, inadequate sanitation and poor hygiene. Our study aims to investigate the impact of a community-level hygiene education program and a water quality intervention using riverbank filtration (RBF) technology on diarrhoeal prevalence. METHODS AND ANALYSIS: We have designed a stepped wedge cluster randomised trial to estimate the health impacts of our intervention in 4 rural villages in Karnataka, India...
March 17, 2017: BMJ Open
https://www.readbyqxmd.com/read/28243672/a-new-model-of-collaborative-research-experiences-from-one-of-australia-s-nhmrc-partnership-centres-for-better-health
#6
Sonia Wutzke, Sally Redman, Adrian Bauman, Penelope Hawe, Alan Shiell, Sarah Thackway, Andrew Wilson
There is often a disconnection between the creation of evidence and its use in policy and practice. Cross-sectoral, multidisciplinary partnership research, founded on shared governance and coproduction, is considered to be one of the most effective means of overcoming this research-policy-practice disconnect. Similar to a number of funding bodies internationally, Australia's National Health and Medical Research Council has introduced Partnership Centres for Better Health: a scheme explicitly designed to encourage coproduced partnership research...
February 15, 2017: Public Health Research & Practice
https://www.readbyqxmd.com/read/28203120/international-lessons-in-new-methods-for-grading-and-integrating-cost-effectiveness-evidence-into-clinical-practice-guidelines
#7
REVIEW
Kathryn M Antioch, Michael F Drummond, Louis W Niessen, Hindrik Vondeling
Economic evidence is influential in health technology assessment world-wide. Clinical Practice Guidelines (CPG) can enable economists to include economic information on health care provision. Application of economic evidence in CPGs, and its integration into clinical practice and national decision making is hampered by objections from professions, paucity of economic evidence or lack of policy commitment. The use of state-of-art economic methodologies will improve this. Economic evidence can be graded by 'checklists' to establish the best evidence for decision making given methodological rigor...
2017: Cost Effectiveness and Resource Allocation: C/E
https://www.readbyqxmd.com/read/28069732/weight-management-practices-associated-with-pcos-and-their-relationships-with-diet-and-physical-activity
#8
L J Moran, W J Brown, S A McNaughton, A E Joham, H J Teede
STUDY QUESTION: Do weight management practices differ in women with and without PCOS? SUMMARY ANSWER: Women in the general population with self-reported PCOS are more likely to be using healthy weight management practices and alternative non-lifestyle measures for weight management than women without PCOS. WHAT IS KNOWN ALREADY: Lifestyle management is the first-line treatment in PCOS. However, the specific weight management practices used by women with PCOS and their effect on diet and physical activity are unclear...
March 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28048615/tu-h-202-04-the-vampire-challenge-preliminary-results-from-a-multi-institutional-study-of-ct-ventilation-image-accuracy
#9
J Kipritidis
CT ventilation imaging is an exciting functional imaging modality that combines four-dimensional computed tomography (4DCT) and deformable image registration (DIR) to provide exquisite ventilation maps of the lung. CT ventilation imaging can be used for: (1) Functional avoidance in thoracic radiation therapy, (2) Imaging longitudinal changes in regional lung function for treatment assessment and adaptation, (3) Image-assisted diagnosis of non-oncologic respiratory diseases. CT ventilation imaging uses CT, a predominantly anatomic imaging modality, and through imaging processing creates functional images...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048557/tu-h-202-00-ct-ventilation-imaging-the-new-clinical-reality-of-functional-avoidance-and-response-assessment-in-lung-cancer-radiation-therapy
#10
Paul Keall
CT ventilation imaging is an exciting functional imaging modality that combines four-dimensional computed tomography (4DCT) and deformable image registration (DIR) to provide exquisite ventilation maps of the lung. CT ventilation imaging can be used for: (1) Functional avoidance in thoracic radiation therapy, (2) Imaging longitudinal changes in regional lung function for treatment assessment and adaptation, (3) Image-assisted diagnosis of non-oncologic respiratory diseases. CT ventilation imaging uses CT, a predominantly anatomic imaging modality, and through imaging processing creates functional images...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048525/we-ab-207a-11-respiratory-motion-guided-4dcbct-a-step-towards-controlling-4dcbct-image-quality
#11
R O'Brien, U Stankovic, P Keall, J Sonke
PURPOSE: We have developed a method, called respiratory motion guided 4DCBCT (RMG-4DCBCT), in which the gantry speed and projection frequency are varied in response to the patient's real-time respiratory signal to eliminate streaking artifacts and to suppress duplicate projections in 4DCBCT images. In 2015, we realized RMG-4DCBCT on an Elekta Synergy linear accelerator with a mechanical relay to suppress projections and a potentiometer to adjust the gantry speed in response to the patient's real-time respiratory signal...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048105/su-g-bra-17-tracking-multiple-targets-with-independent-motion-in-real-time-using-a-multi-leaf-collimator
#12
Y Ge, P Keall, P Poulsen
PURPOSE: Multiple targets with large intrafraction independent motion are often involved in advanced prostate, lung, abdominal, and head and neck cancer radiotherapy. Current standard of care treats these with the originally planned fields, jeopardizing the treatment outcomes. A real-time multi-leaf collimator (MLC) tracking method has been developed to address this problem for the first time. This study evaluates the geometric uncertainty of the multi-target tracking method. METHODS: Four treatment scenarios are simulated based on a prostate IMAT plan to treat a moving prostate target and static pelvic node target: 1) real-time multi-target MLC tracking; 2) real-time prostate-only MLC tracking; 3) correcting for prostate interfraction motion at setup only; and 4) no motion correction...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047895/tu-h-202-01-introduction-to-ct-ventilation-imaging-principles-validation-and-clinical-translation
#13
T Yamamoto
CT ventilation imaging is an exciting functional imaging modality that combines four-dimensional computed tomography (4DCT) and deformable image registration (DIR) to provide exquisite ventilation maps of the lung. CT ventilation imaging can be used for: (1) Functional avoidance in thoracic radiation therapy, (2) Imaging longitudinal changes in regional lung function for treatment assessment and adaptation, (3) Image-assisted diagnosis of non-oncologic respiratory diseases. CT ventilation imaging uses CT, a predominantly anatomic imaging modality, and through imaging processing creates functional images...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047233/tu-h-202-02-applications-validation-clinical-endpoints-and-opportunities-for-ct-ventilation
#14
Y Vinogradskiy
CT ventilation imaging is an exciting functional imaging modality that combines four-dimensional computed tomography (4DCT) and deformable image registration (DIR) to provide exquisite ventilation maps of the lung. CT ventilation imaging can be used for: (1) Functional avoidance in thoracic radiation therapy, (2) Imaging longitudinal changes in regional lung function for treatment assessment and adaptation, (3) Image-assisted diagnosis of non-oncologic respiratory diseases. CT ventilation imaging uses CT, a predominantly anatomic imaging modality, and through imaging processing creates functional images...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046563/tu-h-202-03-spatial-distributions-of-radiation-induced-pulmonary-changes-can-be-modeled-and-utilized-for-image-guided-planning-and-therapy-to-improve-pulmonary-function-preservation-and-hence-the-therapeutic-ratio-for-lung-cancer
#15
J Bayouth
CT ventilation imaging is an exciting functional imaging modality that combines four-dimensional computed tomography (4DCT) and deformable image registration (DIR) to provide exquisite ventilation maps of the lung. CT ventilation imaging can be used for: (1) Functional avoidance in thoracic radiation therapy, (2) Imaging longitudinal changes in regional lung function for treatment assessment and adaptation, (3) Image-assisted diagnosis of non-oncologic respiratory diseases. CT ventilation imaging uses CT, a predominantly anatomic imaging modality, and through imaging processing creates functional images...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/27942799/interrupting-prolonged-sitting-in-type-2-diabetes-nocturnal-persistence-of-improved-glycaemic-control
#16
Paddy C Dempsey, Jennifer M Blankenship, Robyn N Larsen, Julian W Sacre, Parneet Sethi, Nora E Straznicky, Neale D Cohen, Ester Cerin, Gavin W Lambert, Neville Owen, Bronwyn A Kingwell, David W Dunstan
AIMS/HYPOTHESIS: We aimed to examine the effect of interrupting 7 h prolonged sitting with brief bouts of walking or resistance activities on 22 h glucose homeostasis (including nocturnal-to-following morning hyperglycaemia) in adults with type 2 diabetes. METHODS: This study is an extension of a previously published randomised crossover trial, which included 24 inactive overweight/obese adults with type 2 diabetes (14 men; 62 ± 6 years) who completed three 7 h laboratory conditions, separated by 6-14 day washout periods: SIT: (1) prolonged sitting (control); (2) light-intensity walking (LW): sitting plus 3 min bouts of light-intensity walking at 3...
March 2017: Diabetologia
https://www.readbyqxmd.com/read/27907900/insulin-resistance-in-polycystic-ovary-syndrome-a-systematic-review-and-meta-analysis-of-euglycaemic-hyperinsulinaemic-clamp-studies
#17
Samantha Cassar, Marie L Misso, William G Hopkins, Christopher S Shaw, Helena J Teede, Nigel K Stepto
STUDY QUESTION: What is the degree of intrinsic insulin resistance (IR) in women with polycystic ovary syndrome (PCOS) and the relative contribution of BMI to overall IR based on meta-analysis of gold standard insulin clamp studies? SUMMARY ANSWER: We report an inherent reduction (-27%) of insulin sensitivity (IS) in PCOS patients, which was independent of BMI. WHAT IS ALREADY KNOWN: PCOS is prevalent, complex and underpinned by IR but controversies surround the degree of intrinsic IR in PCOS, the effect of BMI and the impact of the different diagnostic criteria (NIH versus Rotterdam) in PCOS...
November 2016: Human Reproduction
https://www.readbyqxmd.com/read/27906918/newborn-vitamin-k-prophylaxis-an-analysis-of-information-resources-for-parents-and-professionals
#18
MULTICENTER STUDY
Hayleigh Miller, Benjamin Wheeler, Nikki Kerruish
AIMS: Vitamin K prophylaxis represents one of the first healthcare decisions families make for their newborn. Information resources are an important component of this process. This study aimed to identify and analyse written information about vitamin K. METHODS: Resources concerning vitamin K prophylaxis for both parents and health professionals were accessed through tertiary hospitals in New Zealand and Australia, midwives associated with Queen Mary Maternity Centre (Dunedin, New Zealand), antenatal class providers in the Dunedin, New Zealand area, and an online search of Australian and New Zealand government and hospital websites, as well as the Centre for Disease Control (CDC) in the US...
December 2, 2016: New Zealand Medical Journal
https://www.readbyqxmd.com/read/27903038/clinical-practice-guidelines-and-principles-of-care-for-people-with-dementia-in-australia
#19
REVIEW
Suzanne M Dyer, Kate Laver, Constance D Pond, Robert G Cumming, Craig Whitehead, Maria Crotty
BACKGROUND: Dementia is a national health priority in Australia. Most people with dementia are over the age of 65 years, have a number of comorbidities and experience a trajectory of functional decline. General practitioners (GPs) have an important role in the diagnosis and management of people with dementia. The Cognitive Decline Partnership Centre's Clinical practice guidelines and principles of care for people with dementia (Guidelines) was recently approved by the National Health and Medical Research Council (NHMRC)...
December 2016: Australian Family Physician
https://www.readbyqxmd.com/read/27799450/mobile-health-mhealth-for-headache-disorders-a-review-of-the-evidence-base
#20
Mahsa Mosadeghi-Nik, Marzyeh S Askari, Farhad Fatehi
The aim of this review was to explore and summarise the evidence base for using mobile apps for the management of headache disorders. PubMed, Web of Science, Embase and Scopus were searched for studies reporting the use of mobile health applications (apps) for managing headache disorders. Different combinations of keywords for mobile health, smartphone and headache were used for electronic search. Six studies (two journal papers and four conference papers) met the inclusion criteria and were reviewed. All of the reviewed studies were categorised as the lowest level (level IV) of evidence according to the National Health and Medical Research Council (NHMRC) hierarchy of evidence...
December 2016: Journal of Telemedicine and Telecare
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