keyword
MENU ▼
Read by QxMD icon Read
search

National health and medical research council

keyword
https://www.readbyqxmd.com/read/29145205/decline-in-search-speed-and-verbal-memory-over-26-years-of-midlife-in-a-british-birth-cohort
#1
Daniel Davis, Rebecca Bendayan, Graciela Muniz Terrera, Rebecca Hardy, Marcus Richards, Diana Kuh
BACKGROUND: Cognitive capabilities change in later life, although their onset and rate of decline, and how they are shaped by lifetime socioeconomic position, childhood cognition and adult health status are all unclear. METHODS: From the Medical Research Council National Survey of Health and Development, we analysed 3,192 participants undergoing one or more cognitive assessments at ages 43, 53, 60-64 and 69. Linear mixed models described cognitive trajectories, adjusting for factors across the life course...
November 16, 2017: Neuroepidemiology
https://www.readbyqxmd.com/read/29137869/morbidity-and-mortality-in-homeless-individuals-prisoners-sex-workers-and-individuals-with-substance-use-disorders-in-high-income-countries-a-systematic-review-and-meta-analysis
#2
Robert W Aldridge, Alistair Story, Stephen W Hwang, Merete Nordentoft, Serena A Luchenski, Greg Hartwell, Emily J Tweed, Dan Lewer, Srinivasa Vittal Katikireddi, Andrew C Hayward
BACKGROUND: Inclusion health focuses on people in extremely poor health due to poverty, marginalisation, and multimorbidity. We aimed to review morbidity and mortality data on four overlapping populations who experience considerable social exclusion: homeless populations, individuals with substance use disorders, sex workers, and imprisoned individuals. METHODS: For this systematic review and meta-analysis, we searched MEDLINE, Embase, and the Cochrane Library for studies published between Jan 1, 2005, and Oct 1, 2015...
November 10, 2017: Lancet
https://www.readbyqxmd.com/read/29130810/outcomes-after-angiography-with-sodium-bicarbonate-and-acetylcysteine
#3
Steven D Weisbord, Martin Gallagher, Hani Jneid, Santiago Garcia, Alan Cass, Soe-Soe Thwin, Todd A Conner, Glenn M Chertow, Deepak L Bhatt, Kendrick Shunk, Chirag R Parikh, Edward O McFalls, Mary Brophy, Ryan Ferguson, Hongsheng Wu, Maria Androsenko, John Myles, James Kaufman, Paul M Palevsky
Background Intravenous sodium bicarbonate and oral acetylcysteine are widely used to prevent acute kidney injury and associated adverse outcomes after angiography without definitive evidence of their efficacy. Methods Using a 2-by-2 factorial design, we randomly assigned 5177 patients at high risk for renal complications who were scheduled for angiography to receive intravenous 1.26% sodium bicarbonate or intravenous 0.9% sodium chloride and 5 days of oral acetylcysteine or oral placebo; of these patients, 4993 were included in the modified intention-to-treat analysis...
November 12, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/29113612/socioeconomic-inequalities-in-resilience-and-vulnerability-among-older-adults-a-population-based-birth-cohort-analysis
#4
T D Cosco, R Cooper, D Kuh, M Stafford
BACKGROUND: Aging is associated with declines in physical capability; however, some individuals demonstrate high well-being despite this decline, i.e. they are "resilient." We examined socioeconomic position (SEP) and resilience and the influence of potentially modifiable behavioral resources, i.e. social support and leisure time physical activity (LTPA), on these relationships. METHODS: Data came from the Medical Research Council National Survey of Health and Development, a nationally-representative birth cohort study...
November 8, 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/29102990/process-evaluation-of-a-primary-healthcare-validation-study-of-a-culturally-adapted-depression-screening-tool-for-use-by-aboriginal-and-torres-strait-islander-people-study-protocol
#5
Sara Farnbach, John Evans, Anne-Marie Eades, Graham Gee, Jamie Fernando, Belinda Hammond, Matty Simms, Karrina DeMasi, Maree Hackett
INTRODUCTION: Process evaluations are conducted alongside research projects to identify the context, impact and consequences of research, determine whether it was conducted per protocol and to understand how, why and for whom an intervention is effective. We present a process evaluation protocol for the Getting it Right research project, which aims to determine validity of a culturally adapted depression screening tool for use by Aboriginal and Torres Strait Islander people. In this process evaluation, we aim to: (1) explore the context, impact and consequences of conducting Getting It Right, (2) explore primary healthcare staff and community representatives' experiences with the research project, (3) determine if it was conducted per protocol and (4) explore experiences with the depression screening tool, including perceptions about how it could be implemented into practice (if found to be valid)...
November 3, 2017: BMJ Open
https://www.readbyqxmd.com/read/29092900/markers-of-pubertal-timing-and-leisure-time-physical-activity-from-ages-36-to-68-years-findings-from-a-british-birth-cohort
#6
Ahmed Elhakeem, Rachel Cooper, David Bann, Diana Kuh, Rebecca Hardy
OBJECTIVES: We aimed to examine associations between markers of pubertal timing and leisure-time physical activity (LTPA) from ages 36 to 68 years in men and women from the Medical Research Council National Survey of Health and Development. STUDY DESIGN: Pubertal timing was ascertained by physicians at age 14-15 years. Boys were grouped, based on their secondary sexual characteristics, as prepubescent, in early-stage puberty, advanced stage puberty or fully mature at age 14-15 years...
November 1, 2017: BMJ Open
https://www.readbyqxmd.com/read/29081267/delayed-versus-immediate-cord-clamping-in-preterm-infants
#7
William Tarnow-Mordi, Jonathan Morris, Adrienne Kirby, Kristy Robledo, Lisa Askie, Rebecca Brown, Nicholas Evans, Sarah Finlayson, Michael Fogarty, Val Gebski, Alpana Ghadge, Wendy Hague, David Isaacs, Michelle Jeffery, Anthony Keech, Martin Kluckow, Himanshu Popat, Lucille Sebastian, Kjersti Aagaard, Michael Belfort, Mohan Pammi, Mohamed Abdel-Latif, Graham Reynolds, Shabina Ariff, Lumaan Sheikh, Yan Chen, Paul Colditz, Helen Liley, Margo Pritchard, Daniele de Luca, Koert de Waal, Peta Forder, Lelia Duley, Walid El-Naggar, Andrew Gill, John Newnham, Karen Simmer, Katie Groom, Philip Weston, Joanna Gullam, Harshad Patel, Guan Koh, Kei Lui, Neil Marlow, Scott Morris, Arvind Sehgal, Euan Wallace, Roger Soll, Leslie Young, David Sweet, Susan Walker, Andrew Watkins, Ian Wright, David Osborn, John Simes
Background The preferred timing of umbilical-cord clamping in preterm infants is unclear. Methods We randomly assigned fetuses from women who were expected to deliver before 30 weeks of gestation to either immediate clamping of the umbilical cord (≤10 seconds after delivery) or delayed clamping (≥60 seconds after delivery). The primary composite outcome was death or major morbidity (defined as severe brain injury on postnatal ultrasonography, severe retinopathy of prematurity, necrotizing enterocolitis, or late-onset sepsis) by 36 weeks of postmenstrual age...
October 29, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/29074409/global-prevalence-of-injecting-drug-use-and-sociodemographic-characteristics-and-prevalence-of-hiv-hbv-and-hcv-in-people-who-inject-drugs-a-multistage-systematic-review
#8
Louisa Degenhardt, Amy Peacock, Samantha Colledge, Janni Leung, Jason Grebely, Peter Vickerman, Jack Stone, Evan B Cunningham, Adam Trickey, Kostyantyn Dumchev, Michael Lynskey, Paul Griffiths, Richard P Mattick, Matthew Hickman, Sarah Larney
BACKGROUND: Sharing of equipment used for injecting drug use (IDU) is a substantial cause of disease burden and a contributor to blood-borne virus transmission. We did a global multistage systematic review to identify the prevalence of IDU among people aged 15-64 years; sociodemographic characteristics of and risk factors for people who inject drugs (PWID); and the prevalence of HIV, hepatitis C virus (HCV), and hepatitis B virus (HBV) among PWID. METHODS: Consistent with the GATHER and PRISMA guidelines and without language restrictions, we systematically searched peer-reviewed databases (MEDLINE, Embase, and PsycINFO; articles published since 2008, latest searches in June, 2017), searched the grey literature (websites and databases, searches between April and August, 2016), and disseminated data requests to international experts and agencies (requests sent in October, 2016)...
October 23, 2017: Lancet Global Health
https://www.readbyqxmd.com/read/29066090/genetic-variants-associated-with-susceptibility-to-idiopathic-pulmonary-fibrosis-in-people-of-european-ancestry-a-genome-wide-association-study
#9
Richard J Allen, Joanne Porte, Rebecca Braybrooke, Carlos Flores, Tasha E Fingerlin, Justin M Oldham, Beatriz Guillen-Guio, Shwu-Fan Ma, Tsukasa Okamoto, Alison E John, Ma'en Obeidat, Ivana V Yang, Amanda Henry, Richard B Hubbard, Vidya Navaratnam, Gauri Saini, Norma Thompson, Helen L Booth, Simon P Hart, Mike R Hill, Nik Hirani, Toby M Maher, Robin J McAnulty, Ann B Millar, Philip L Molyneaux, Helen Parfrey, Doris M Rassl, Moira K B Whyte, William A Fahy, Richard P Marshall, Eunice Oballa, Yohan Bossé, David C Nickle, Don D Sin, Wim Timens, Nick Shrine, Ian Sayers, Ian P Hall, Imre Noth, David A Schwartz, Martin D Tobin, Louise V Wain, R Gisli Jenkins
BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a chronic progressive lung disease with high mortality, uncertain cause, and few treatment options. Studies have identified a significant genetic risk associated with the development of IPF; however, mechanisms by which genetic risk factors promote IPF remain unclear. We aimed to identify genetic variants associated with IPF susceptibility and provide mechanistic insight using gene and protein expression analyses. METHODS: We used a two-stage approach: a genome-wide association study in patients with IPF of European ancestry recruited from nine different centres in the UK and controls selected from UK Biobank (stage 1) matched for age, sex, and smoking status; and a follow-up of associated genetic variants in independent datasets of patients with IPF and controls from two independent US samples from the Chicago consortium and the Colorado consortium (stage 2)...
November 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/29061335/research-investments-for-uk-infectious-disease-research-1997-2013-a-systematic-analysis-of-awards-to-uk-institutions-alongside-national-burden-of-disease
#10
Michael G Head, Rebecca J Brown, Stuart C Clarke
INTRODUCTION: Infectious disease remains a significant burden in the UK and the focus of significant amounts of research investment each year. The Research Investments in Global Health study has systematically assessed levels of funding for infection research, and here considers investment alongside UK burden of individual infectious diseases. METHODS: The study included awards to UK institutions between 1997 and 2013 that were related to infectious disease. Awards related to global health projects were excluded here...
October 20, 2017: Journal of Infection
https://www.readbyqxmd.com/read/29058665/real-time-modelling-of-a-pandemic-influenza-outbreak
#11
Paul J Birrell, Richard G Pebody, André Charlett, Xu-Sheng Zhang, Daniela De Angelis
BACKGROUND: Real-time modelling is an essential component of the public health response to an outbreak of pandemic influenza in the UK. A model for epidemic reconstruction based on realistic epidemic surveillance data has been developed, but this model needs enhancing to provide spatially disaggregated epidemic estimates while ensuring that real-time implementation is feasible. OBJECTIVES: To advance state-of-the-art real-time pandemic modelling by (1) developing an existing epidemic model to capture spatial variation in transmission, (2) devising efficient computational algorithms for the provision of timely statistical analysis and (3) incorporating the above into freely available software...
October 2017: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/29057731/-research-in-the-gp-s-practice-is-good-for-the-health-of-all
#12
W Opstelten, P J E Bindels, J S Burgers
The Health Council of the Netherlands has issued a report on the importance of extramural medical research. More attention is needed for diseases with high prevalence or a high disease burden, and results from intramural research cannot always be extrapolated to the primary care setting. Scientific research is crucial for developing and evaluating primary health care, so all general practitioners (GPs) should at least open their practices to data collection for scientific research purposes. Additionally, researchers from departments of general practice, together with healthcare professionals, should develop research questions that are in line with observed knowledge gaps in general practice...
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/29057382/ethnic-variations-in-sexual-behaviours-and-sexual-health-markers-findings-from-the-third-british-national-survey-of-sexual-attitudes-and-lifestyles-natsal-3
#13
Sonali Wayal, Gwenda Hughes, Pam Sonnenberg, Hamish Mohammed, Andrew J Copas, Makeda Gerressu, Clare Tanton, Martina Furegato, Catherine H Mercer
BACKGROUND: Sexual health entails the absence of disease and the ability to lead a pleasurable and safe sex life. In Britain, ethnic inequalities in diagnoses of sexually transmitted infections (STI) persist; however, the reasons for these inequalities, and ethnic variations in other markers of sexual health, remain poorly understood. We investigated ethnic differences in hypothesised explanatory factors such as socioeconomic factors, substance use, depression, and sexual behaviours, and whether they explained ethnic variations in sexual health markers (reported STI diagnoses, attendance at sexual health clinics, use of emergency contraception, and sexual function)...
October 2017: Lancet. Public Health
https://www.readbyqxmd.com/read/29055243/physiological-vital-sign-ranges-in-newborns-from-34-weeks-gestation-a-systematic-review
#14
REVIEW
Michelle Paliwoda, Karen New, Mark Davies, Fiona Bogossian
CONTEXT: The birth process and the moments thereafter are a crucial time for newborns as they adapt to extra uterine life. The adaptive process begins immediately and can take a number of days to complete. The process involves initiating and maintaining respirations, thermoregulation, and the change from foetal circulation to newborn circulation. The majority of newborns successfully adapt to extra uterine life, some experience difficulty. Early warning tools may assist clinicians identify early signs of failure to adapt and/or deterioration but these are dependent on 'Normal' vital sign reference ranges for triggering an escalation of care...
October 9, 2017: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/29045667/survey-of-reproductive-experiences-and-outcomes-of-cancer-survivors-who-stored-reproductive-material-before-treatment
#15
K Hammarberg, M Kirkman, C Stern, R I McLachlan, G Clarke, F Agresta, D Gook, L Rombauts, B Vollenhoven, J R W Fishe
STUDY QUESTION: What are the reproductive experiences and outcomes of people who store reproductive material before cancer treatment? SUMMARY ANSWER: Of respondents who had tried to achieve pregnancy since completing cancer treatment almost all had succeeded, in most cases through natural conception. WHAT IS KNOWN ALREADY: People of reproductive age who are diagnosed with cancer can cryopreserve reproductive material to guard against the adverse effects on fertility of gonadotoxic treatment...
October 17, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29044420/characterization-of-a-novel-role-for-the-dynamin-mechanoenzymes-in-the-regulation-of-human-sperm-acrosomal-exocytosis
#16
Wei Zhou, Amanda L Anderson, Adrian P Turner, Geoffry N De Iuliis, Adam McCluskey, Eileen A McLaughlin, Brett Nixon
STUDY QUESTION: Does dynamin regulate human sperm acrosomal exocytosis? SUMMARY ANSWER: Our studies of dynamin localization and function have implicated this family of mechanoenzymes in the regulation of progesterone-induced acrosomal exocytosis in human spermatozoa. WHAT IS KNOWN ALREADY: Completion of an acrosome reaction is a prerequisite for successful fertilization in all studied mammalian species. It follows that failure to complete this unique exocytotic event represents a common aetiology in the defective spermatozoa of male infertility patients that have failed IVF in a clinical setting...
October 1, 2017: Molecular Human Reproduction
https://www.readbyqxmd.com/read/29040564/n-cadherin-identifies-human-endometrial-epithelial-progenitor-cells-by-in-vitro-stem-cell-assays
#17
Hong P T Nguyen, L Xiao, James A Deane, Ker-Sin Tan, Fiona L Cousins, Hirotaka Masuda, Carl N Sprung, Anna Rosamilia, Caroline E Gargett
STUDY QUESTION: Is there a specific surface marker that identifies human endometrial epithelial progenitor cells with adult stem cell activity using in vitro assays? SUMMARY ANSWER: N-cadherin isolates clonogenic, self-renewing human endometrial epithelial progenitor cells with high proliferative potential that differentiate into cytokeratin+ gland-like structures in vitro and identifies their location in some cells of gland profiles predominantly in basalis endometrium adjacent to the myometrium...
November 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29034296/diagnosis-of-asthma-in-symptomatic-children-based-on-measures-of-lung-function-an-analysis-of-data-from-a-population-based-birth-cohort-study
#18
Clare Murray, Philip Foden, Lesley Lowe, Hannah Durrington, Adnan Custovic, Angela Simpson
BACKGROUND: Concerns have been expressed about asthma overdiagnosis. The UK National Institute of Health and Care Excellence (NICE) proposed a new diagnostic algorithm applying four lung function measures sequentially (ratio of forced expiratory volume in 1 s [FEV1] to forced vital capacity [FVC] <70%, bronchodilator reversibility ≥12%, fractional exhaled nitric oxide [FeNO] ≥35 parts per billion, and peak expiratory flow variability >20%). We aimed to assess the diagnostic value of three of the tests individually, and then test the proposed algorithm in symptomatic children...
October 2017: Lancet Child Adolesc Health
https://www.readbyqxmd.com/read/29029846/identification-of-novel-risk-loci-for-restless-legs-syndrome-in-genome-wide-association-studies-in-individuals-of-european-ancestry-a-meta-analysis
#19
REVIEW
Barbara Schormair, Chen Zhao, Steven Bell, Erik Tilch, Aaro V Salminen, Benno Pütz, Yves Dauvilliers, Ambra Stefani, Birgit Högl, Werner Poewe, David Kemlink, Karel Sonka, Cornelius G Bachmann, Walter Paulus, Claudia Trenkwalder, Wolfgang H Oertel, Magdolna Hornyak, Maris Teder-Laving, Andres Metspalu, Georgios M Hadjigeorgiou, Olli Polo, Ingo Fietze, Owen A Ross, Zbigniew Wszolek, Adam S Butterworth, Nicole Soranzo, Willem H Ouwehand, David J Roberts, John Danesh, Richard P Allen, Christopher J Earley, William G Ondo, Lan Xiong, Jacques Montplaisir, Ziv Gan-Or, Markus Perola, Pavel Vodicka, Christian Dina, Andre Franke, Lukas Tittmann, Alexandre F R Stewart, Svati H Shah, Christian Gieger, Annette Peters, Guy A Rouleau, Klaus Berger, Konrad Oexle, Emanuele Di Angelantonio, David A Hinds, Bertram Müller-Myhsok, Juliane Winkelmann
BACKGROUND: Restless legs syndrome is a prevalent chronic neurological disorder with potentially severe mental and physical health consequences. Clearer understanding of the underlying pathophysiology is needed to improve treatment options. We did a meta-analysis of genome-wide association studies (GWASs) to identify potential molecular targets. METHODS: In the discovery stage, we combined three GWAS datasets (EU-RLS GENE, INTERVAL, and 23andMe) with diagnosis data collected from 2003 to 2017, in face-to-face interviews or via questionnaires, and involving 15 126 cases and 95 725 controls of European ancestry...
November 2017: Lancet Neurology
https://www.readbyqxmd.com/read/29025442/the-evolution-of-research-participant-protections-in-south-africa
#20
Amaboo Dhai
South Africa (SA) has played a leading role in health research internationally. Ethical guidelines for the protection of research participants have been published by the Medical Research Council (MRC) as early as 1979. Ironically, the guidelines gave substantial prominence to the oppressive laws of the time. In its 4th edition of the guidelines, the MRC placed emphasis on SA needs, and incorporated the principles of the Bill of Rights of the SA Constitution 1996 into its guidelines. The most significant milestone in the history of participant protections in SA was the inclusion of research and experimentation in the Bill of Rights of the Constitution and the statutory legislation of protections in the National Health Act No...
June 30, 2017: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
keyword
keyword
107788
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"