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Oxford center for evidence-based medicine

Dermot P Maher, Lucy Chen, Jianren Mao
Intravenous ketamine infusions have been used extensively to treat often-intractable neuropathic pain conditions. Because there are many widely divergent ketamine infusion protocols described in the literature, the variation in these protocols presents a challenge for direct comparison of one protocol with another and in discerning an optimal protocol. Careful examination of the published literature suggests that ketamine infusions can be useful to treat neuropathic pain and that certain characteristics of ketamine infusions may be associated with better clinical outcomes...
February 2017: Anesthesia and Analgesia
Justin C Chia, P Régine Mydlarski
PURPOSE: Omalizumab is a recombinant humanized monoclonal antibody that inhibits the binding of immunoglobulin E (IgE) to the high-affinity IgE receptor (FceRI) on the surface of mast cells and basophils. Omalizumab has been approved for use in asthma, and new reports show promise in a variety of dermatologic diseases. Herein, we review the literature on omalizumab in dermatology and discuss the safety, efficacy and mechanisms of action for this emerging therapy. MATERIALS AND METHODS: PubMED, MEDLINE and Embase databases were searched for the period 1 January 1990 to 1 September 2016...
November 7, 2016: Journal of Dermatological Treatment
Julie L Holihan, Duyen H Nguyen, Juan R Flores-Gonzalez, Zeinab M Alawadi, Mylan T Nguyen, Tien C Ko, Lillian S Kao, Mike K Liang
BACKGROUND: The literature supporting ventral hernia management is growing; however, it is unclear whether the quality of work is improving. We hypothesize that the quality of clinical ventral hernia research has improved over the past 2.5 decades. METHODS: A review of MEDLINE, Scopus, and Cochrane databases was conducted for all ventral hernia studies from January 1, 1980 to May 1, 2015. Relevant abstracts were assigned a level according to the Oxford Center for Evidence-Based Medicine...
August 2016: Journal of Surgical Research
Shearwood McClelland, Jon H Oren, Themistocles S Protopsaltis, Peter G Passias
Anterior cervical discectomy and fusion (ACDF) performed as an outpatient has become increasingly common for treating cervical spine pathology, largely due to its cost savings compared with inpatient ACDF. Nearly all outpatient ACDF patient reports have originated from single-center studies, with the procedure yet to be addressed via a meta-analysis of the peer-reviewed literature. The Entrez gateway of the PubMed database was used to conduct a comprehensive literature search for articles published in English up to 3/9/16...
December 2016: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
F-X Crahay, J L Nizet
BACKGROUND: Suction-assisted lipectomy is one of the most frequent procedures in plastic surgery. The aim of this study was to investigate whether suction-assisted lipectomy causes changes in the carbohydrates and lipid metabolism and the potential effects on cardiovascular risk factors. METHODS: We interrogated five databases: Medline, American College of Physicians Journal Club Database, Cochrane central register of controlled trials, Cochrane database of systematic reviews, Database of abstracts of reviews of effects...
August 2016: Annales de Chirurgie Plastique et Esthétique
Michael V Ortiz, Rachel Kobos, Michael Walsh, Emily K Slotkin, Stephen Roberts, Michael F Berger, Meera Hameed, David Solit, Marc Ladanyi, Neerav Shukla, Alex Kentsis
BACKGROUND: Pediatric oncologists have begun to leverage tumor genetic profiling to match patients with targeted therapies. At the Memorial Sloan Kettering Cancer Center (MSKCC), we developed the Pediatric Molecular Tumor Board (PMTB) to track, integrate, and interpret clinical genomic profiling and potential targeted therapeutic recommendations. PROCEDURE: This retrospective case series includes all patients reviewed by the MSKCC PMTB from July 2014 to June 2015...
August 2016: Pediatric Blood & Cancer
Adam Z Fink, Lisa B Mogil, Michael L Lipton
The shortage of high-quality systematic reviews in the field of radiology limits evidence-based integration of imaging methods into clinical practice and may perpetuate misconceptions regarding the efficacy and appropriateness of imaging techniques for specific applications. Diffusion tensor imaging for patients with mild traumatic brain injury (DTI-mTBI) and dynamic susceptibility contrast MRI for patients with glioma (DSC-glioma) are applications of quantitative neuroimaging, which similarly detect manifestations of disease where conventional neuroimaging techniques cannot...
May 5, 2016: British Journal of Radiology
Igho J Onakpoya, Carl J Heneghan, Jeffrey K Aronson
We have systematically identified medicinal products withdrawn worldwide because of adverse drug reactions, assessed the level of evidence used for making the withdrawal decisions, and explored the patterns of withdrawals over time. We searched PubMed, the WHO database of withdrawn products, and selected texts. We included products that were withdrawn after launch from 1950 onwards, excluding non-human and over-the-counter medicines. We assessed the levels of evidence on which withdrawals were based using the Oxford Center for Evidence Based Medicine Levels of Evidence...
July 2016: Critical Reviews in Toxicology
Carolina-Cavaliéri Gomes, Ricardo-Santiago Gomez, Lívia-Guimarães Zina, Fabrício-Rezende Amaral
BACKGROUND: Recurrent aphthous stomatitis (RAS) is a recurrent painful ulcerative disorder that commonly affects the oral mucosa. Local and systemic factors such as trauma, food sensitivity, nutritional deficiencies, systemic conditions, immunological disorders and genetic polymorphisms are associated with the development of the disease. Helicobacter pylori (H. pylori) is a gram-negative, microaerophile bacteria, that colonizes the gastric mucosa and it was previously suggested to be involved in RAS development...
March 2016: Medicina Oral, Patología Oral y Cirugía Bucal
Catherine N Tchanque-Fossuo, Derek Ho, Sara E Dahle, Eugene Koo, Chin-Shang Li, R Rivkah Isseroff, Jared Jagdeo
Diabetes mellitus (DM) is a significant international health concern affecting more than 387 million individuals. A diabetic person has a 25% lifetime risk of developing a diabetic foot ulcer (DFU), leading to limb amputation in up to one in six DFU patients. Low-level light therapy (LLLT) uses low-power lasers or light-emitting diodes to alter cellular function and molecular pathways, and may be a promising treatment for DFU. The goal of this systematic review is to examine whether the clinical use of LLLT is effective in the healing of DFU at 12 and 20 weeks in comparison with the standard of care, and to provide evidence-based recommendation and future clinical guidelines for the treatment of DFU using LLLT...
March 2016: Wound Repair and Regeneration
Mina Zarei, Tongyu C Wikramanayake, Leyre Falto-Aizpurua, Lawrence A Schachner, Joaquin J Jimenez
Despite the current treatment options for different types of alopecia, there is a need for more effective management options. Recently, low-level laser therapy (LLLT) was evaluated for stimulating hair growth. Here, we reviewed the current evidence on the LLLT effects with an evidence-based approach, focusing more on randomized controlled studies by critically evaluating them. In order to investigate whether in individuals presenting with hair loss (male pattern hair loss (MPHL), female pattern hair loss (FPHL), alopecia areata (AA), and chemotherapy-induced alopecia (CIA)) LLLT is effective for hair regrowth, several databases including PubMed, Google Scholar, Medline, Embase, and Cochrane Database were searched using the following keywords: Alopecia, Hair loss, Hair growth, Low level laser therapy, Low level light therapy, Low energy laser irradiation, and Photobiomodulation...
February 2016: Lasers in Medical Science
J Keil, P Jung, A Schiele, B Urban, A Parsch, B Matsche, C Eich, K Becke, B Landsleitner, S G Russo, M Bernhard, T Nicolai, F Hoffmann
BACKGROUND: Airway management with supraglottic airway devices (SGA) in life-threatening emergencies involving children is becoming increasingly more important. The laryngeal mask (LM) and the laryngeal tube (LT) are devices commonly used for this purpose. This article presents a literature review and consensus statement by various societies on the use of SGA in pediatric emergency medicine. MATERIAL AND METHODS: Literature search in the database PubMed and classification of studies according to the criteria of the Oxford Centre for Evidence-based Medicine levels of evidence...
January 2016: Der Anaesthesist
Ralf Baron, Andreas Binder, Rolf Biniek, Stephan Braune, Hartmut Buerkle, Peter Dall, Sueha Demirakca, Rahel Eckardt, Verena Eggers, Ingolf Eichler, Ingo Fietze, Stephan Freys, Andreas Fründ, Lars Garten, Bernhard Gohrbandt, Irene Harth, Wolfgang Hartl, Hans-Jürgen Heppner, Johannes Horter, Ralf Huth, Uwe Janssens, Christine Jungk, Kristin Maria Kaeuper, Paul Kessler, Stefan Kleinschmidt, Matthias Kochanek, Matthias Kumpf, Andreas Meiser, Anika Mueller, Maritta Orth, Christian Putensen, Bernd Roth, Michael Schaefer, Rainhild Schaefers, Peter Schellongowski, Monika Schindler, Reinhard Schmitt, Jens Scholz, Stefan Schroeder, Gerhard Schwarzmann, Claudia Spies, Robert Stingele, Peter Tonner, Uwe Trieschmann, Michael Tryba, Frank Wappler, Christian Waydhas, Bjoern Weiss, Guido Weisshaar
In 2010, under the guidance of the DGAI (German Society of Anaesthesiology and Intensive Care Medicine) and DIVI (German Interdisciplinary Association for Intensive Care and Emergency Medicine), twelve German medical societies published the "Evidence- and Consensus-based Guidelines on the Management of Analgesia, Sedation and Delirium in Intensive Care". Since then, several new studies and publications have considerably increased the body of evidence, including the new recommendations from the American College of Critical Care Medicine (ACCM) in conjunction with Society of Critical Care Medicine (SCCM) and American Society of Health-System Pharmacists (ASHP) from 2013...
2015: German Medical Science: GMS E-journal
Sophie Lachance, Neil K Chadha
BACKGROUND: Piriform fossa sinus tracts (PFSTs) are a recognized cause of recurrent deep neck infections in the pediatric population. Conventional management has historically required open resection, but over recent years minimally invasive endoscopic approaches to obliterate the pharyngeal opening of the sinus have been performed in many centers. However, there is a lack of clear evidence regarding the success rate and safety of these approaches. OBJECTIVE: To determine the success rate of endoscopic management of PFST through a systematic review of the existing literature...
February 2016: Otolaryngology—Head and Neck Surgery
Qing Pang, Kai Qu, Jian-Bin Bi, Su-Shun Liu, Jing-Yao Zhang, Si-Dong Song, Ting Lin, Xin-Sen Xu, Yong Wan, Ming-Hui Tai, Hao-Chen Liu, Ya-Feng Dong, Chang Liu
AIM: To investigate the association between thrombocytopenia and relapse after treatment for hepatocellular carcinoma (HCC). METHODS: We searched the PubMed, EMBASE, and Web of Science databases to obtain eligible studies. The hazard ratios (HRs) values and 95% confidence intervals (CIs) were pooled by random effects model. Subsequently, we estimated the heterogeneity, performed a sensitivity analysis, determined the publication bias, and performed subgroup and meta-regression analyses...
July 7, 2015: World Journal of Gastroenterology: WJG
Anne-Marie E Sirany, Rachel M Nygaard, Jeffrey J Morken
BACKGROUND: The ligation of the intersphincteric fistula tract procedure, a sphincter-preserving technique, aims to obtain complete, durable healing, while preserving fecal continence in the treatment of transsphincteric anal fistulas. OBJECTIVE: This was a systematic review to evaluate the outcomes of the originally described (classic) ligation of the intersphincteric fistula tract procedure and the identified technical variations of the procedure. DATA SOURCES: PubMed, Web of Science, and the archive of Diseases of the Colon & Rectum were searched with the terms "ligation of intersphincteric fistula" and "ligation of intersphincteric fistula tract...
June 2015: Diseases of the Colon and Rectum
Inmaculada Calvo, Jordi Antón, Sagrario Bustabad, Marisol Camacho, Jaime de Inocencio, M Luz Gamir, Jenaro Graña, Lucía La Cruz, Juan Carlos López Robledillo, Marta Medrano, Rosa Merino, Consuelo Modesto, Esmeralda Nuñez, M Jesús Rua, Vicenç Torrente-Segarra, Carmen Vargas, Loreto Carmona, Estíbaliz Loza
To develop recommendations on the transition from pediatric care to adult care in patients with chronic inflammatory rheumatic diseases with childhood onset based. Recommendations were generated following nominal group methodology and Delphi technique. A panel of 16 experts was established. A systematic literature review (on transitional care) and a narrative review were performed and presented to the panel in the first panel meeting to be discussed. A first draft of recommendations was generated and circulated...
October 2015: Rheumatology International
Ashish Kumar, Subrat K Acharya, Shivaram P Singh, Vivek A Saraswat, Anil Arora, Ajay Duseja, Mahesh K Goenka, Deepali Jain, Premashish Kar, Manoj Kumar, Vinay Kumaran, Kunisshery M Mohandas, Dipanjan Panda, Shashi B Paul, Jeyamani Ramachandran, Hariharan Ramesh, Padaki N Rao, Samir R Shah, Hanish Sharma, Ragesh B Thandassery
Hepatocellular carcinoma (HCC) is one of the major causes of morbidity, mortality and healthcare expenditure in patients with chronic liver disease. There are no consensus guidelines on diagnosis and management of HCC in India. The Indian National Association for Study of the Liver (INASL) set up a Task-Force on HCC in 2011, with a mandate to develop consensus guidelines for diagnosis and management of HCC, relevant to disease patterns and clinical practices in India. The Task-Force first identified various contentious issues on various aspects of HCC and these issues were allotted to individual members of the Task-Force who reviewed them in detail...
August 2014: Journal of Clinical and Experimental Hepatology
Javier Ata-Ali, Fadi Ata-Ali, Nicolas Di-Benedetto, Leticia Bagán, José-Vicente Bagán
OBJECTIVE: A systematic review is made to determine whether human immunodeficiency virus (HIV) infection has an impact upon dental implant osseointegration. STUDY DESIGN: A PubMed (MEDLINE) literature search was made of articles published up until 14 April 2014. The systematic review was conducted based on the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA). The quality of the studies included in the review was assessed using the Methodological Index for Nonrandomized Studies (MINORS) and levels of evidence (based on the University of Oxford's Center for Evidence Based Medicine criteria)...
May 2015: Medicina Oral, Patología Oral y Cirugía Bucal
Ahmed A Hussein, Austin S Adams, Justin H Turner
OBJECTIVES: Patulous Eustachian tube (PET) is a challenging clinical problem with limited medical and surgical options. The current study systematically reviews the literature to determine the safety and efficacy of surgical treatments for PET. DATA SOURCES: Medline, Google Scholar, and Cochrane databases. METHODS: Studies evaluating the surgical management of PET were extracted based on defined inclusion criteria. Data including surgical techniques, outcomes, and complications were extracted and analyzed...
September 2015: Laryngoscope
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