keyword
https://read.qxmd.com/read/38478773/cannabis-and-cannabinoids-in-adults-with-cancer-asco-guideline
#21
JOURNAL ARTICLE
Ilana M Braun, Kari Bohlke, Donald I Abrams, Holly Anderson, Lynda G Balneaves, Gil Bar-Sela, Daniel W Bowles, Peter R Chai, Anuja Damani, Arjun Gupta, Sigrun Hallmeyer, Ishwaria M Subbiah, Chris Twelves, Mark S Wallace, Eric J Roeland
PURPOSE: To guide clinicians, adults with cancer, caregivers, researchers, and oncology institutions on the medical use of cannabis and cannabinoids, including synthetic cannabinoids and herbal cannabis derivatives; single, purified cannabinoids; combinations of cannabis ingredients; and full-spectrum cannabis. METHODS: A systematic literature review identified systematic reviews, randomized controlled trials (RCTs), and cohort studies on the efficacy and safety of cannabis and cannabinoids when used by adults with cancer...
March 13, 2024: Journal of Clinical Oncology
https://read.qxmd.com/read/38477667/the-anti-emetic-actions-of-gip-receptor-agonism
#22
REVIEW
Tito Borner, Bart C De Jonghe, Matthew R Hayes
Nausea and vomiting are primitive aspects of mammalian physiology and behavior that ensure survival. Unfortunately, both are ubiquitously present side effects of drug treatments for many chronic diseases with negative consequences on pharmacotherapy tolerance, quality of life, and prognosis. One of the most critical clinical examples is the profound emesis and nausea that occur in patients undergoing chemotherapy, which continue to be among the most distressing side effects, even with the use of modern anti-emetic medications...
March 13, 2024: American Journal of Physiology. Endocrinology and Metabolism
https://read.qxmd.com/read/38472493/discussing-the-safety-and-effectiveness-of-transcatheter-arterial-embolization-combined-with-intravenous-chemotherapy-in-treating-locally-advanced-breast-cancer
#23
RANDOMIZED CONTROLLED TRIAL
Jingjun Zhang, Jie Zhang, Xiangke Niu, Yongxiang Zhou, Yufeng Guo, Yuanzhi Wang, Feng Shou
To investigate the efficacy and safety of drug-eluting bead-transarterial chemoembolization (DEB-TACE) combined with systemic chemotherapy in HR+/Her2- locally advanced breast cancer (LABC) patients. A controlled study was conducted on LABC patients treated at Jianyang People's Hospital and the First Affiliated Hospital of Chengdu Medical College from December 2020 to June 2022. The patients were randomly divided into the experimental group and the control group. The experimental group received DEB-TACE combined with the TAC regimen (175 mg/m2 paclitaxel-loaded albumin, 50 mg/m2 Doxorubicin, and 500 mg/m2 cyclophosphamide), while the control group received the TAC regimen intravenously...
March 12, 2024: Scientific Reports
https://read.qxmd.com/read/38466055/risk-factors-for-cancer-malnutrition-after-radical-tumor-resection
#24
JOURNAL ARTICLE
Yang Ting, Zhou Jinhua
OBJECTIVE: To investigate the risk factors for cancer malnutrition after radical tumor resection. METHODS: A total of 110 cancer patients who used parenteral nutrition from January 2022 to June 2023 were selected for retrospective analysis and 50 patients who did not need parenteral nutrition support after radical tumor resection were selected as the control group to analyze the general data of the two groups. Univariate and multivariate logistic analyses were used to determine the factors influencing malnutrition in patients supported by parenteral nutrition after radical tumor resection...
March 8, 2024: Alternative Therapies in Health and Medicine
https://read.qxmd.com/read/38463543/efficacy-and-safety-of-hepasphere-drug-eluting-bead-transarterial-chemoembolization-combined-with-hepatic-arterial-infusion-chemotherapy-as-the-second-line-treatment-in-advanced-hepatocellular-carcinoma
#25
JOURNAL ARTICLE
Baojiang Liu, Song Gao, Jianhai Guo, Fuxin Kou, Shaoxing Liu, Xin Zhang, Aiwei Feng, Xiaodong Wang, Guang Cao, Hui Chen, Peng Liu, Haifeng Xu, Qinzong Gao, Renjie Yang, Liang Xu, Xu Zhu
PURPOSE: Recently, hepatic arterial infusion chemotherapy (HAIC) has also gained popularity for hepatocellular carcinoma (HCC). Several studies have compared HAIC and Transarterial chemoembolization (TACE). However, comparisons between TACE plus HAIC and HAIC are rarely reported. Here, we evaluated the performance of HepaSphere DEB-TACE combined with HAIC (Hepa-HAIC) compared to HAIC in patients with advanced HCC. PATIENTS AND METHODS: In this retrospective study, we enrolled 167 patients diagnosed with advanced HCC and treated at Peking University Cancer Hospital from May 2018 to May 2022...
2024: Journal of Hepatocellular Carcinoma
https://read.qxmd.com/read/38461442/effect-of-ginger-and-p6-acupressure-on-chemotherapy-induced-nausea-and-vomiting-a-randomized-controlled-study
#26
JOURNAL ARTICLE
Xiao Chenbing, Xia Huiling, Xing Qianqian, Wang Dan, Xie Guilan, Yang Ling, Xie Lingling, Qian Weiwei
OBJECTIVE: To evaluate the effect of ginger with P6 acupressure in preventing and treating chemotherapy-induced nausea and vomiting (CINV) in cancer patients. METHOD: A total of 172 participants were randomly divided into the control, ginger, acupressure, and joint groups, who were hospitalized in the Affiliated Hospital of Xuzhou Medical University from February and September 2022. The baseline characteristics, nausea, vomiting, and retching, benefit finding, functional living index-emesis, treatment satisfaction, and adverse reaction, were used in data collection...
2024: Revista da Escola de Enfermagem da U S P
https://read.qxmd.com/read/38458657/2023-mascc-and-esmo-guideline-update-for-the-prevention-of-chemotherapy-and-radiotherapy-induced-nausea-and-vomiting
#27
J Herrstedt, R Clark-Snow, C H Ruhlmann, A Molassiotis, I Olver, B L Rapoport, M Aapro, K Dennis, P J Hesketh, R M Navari, L Schwartzberg, M L Affronti, M A Garcia-Del-Barrio, A Chan, L Celio, R Chow, M Fleury, R J Gralla, R Giusti, F Jahn, H Iihara, E Maranzano, V Radhakrishnan, M Saito, P Sayegh, S Bosnjak, L Zhang, J Lee, V Ostwal, T Smit, A Zilic, K Jordan, F Scotté
• Nausea and vomiting are considered amongst the most troublesome adverse events for patients receiving antineoplastics. • The guideline covers emetic risk classification, prevention and management of treatment-induced nausea and vomiting. • The Consensus Committee consisted of 34 multidisciplinary, health care professionals and three patient advocates. • Recommendations are based on evidence-based data (level of evidence) and the authors’ collective expert opinion (grade)...
February 2024: ESMO Open
https://read.qxmd.com/read/38457191/deletion-of-concurrent-chemotherapy-on-the-basis-of-sequential-chemoradiotherapy-for-non-metastatic-stage-t4-nasopharyngeal-carcinoma-in-imrt-era
#28
JOURNAL ARTICLE
Yuming Zheng, Fen Xue, Dan Ou, Xiaoshuang Niu, Chaosu Hu, Xiayun He
PURPOSE: Intensity-modulated radiotherapy (IMRT) combined with concurrent chemotherapy is deemed as the mainstay treatment in locoregionally advanced nasopharyngeal carcinoma (NPC). Nevertheless, the tolerance of severe acute toxicity of concurrent chemotherapy was unsatisfied. In addition, T4 is the predicting factor of poor prognosis for NPC patients. In this retrospective analysis, the long-term outcomes IMRT combined by induction chemotherapy deleting concurrent chemotherapy with or without adjuvant chemotherapy for T4 non-metastatic NPC were analyzed...
February 2024: Cancer Medicine
https://read.qxmd.com/read/38456612/in-reply-olanzapine-for-chemotherapy-induced-nausea-and-vomiting-pediatric-population-take-home-message
#29
JOURNAL ARTICLE
Jagdish Prasad Meena, Aditya Kumar Gupta, Kana Ram Jat
No abstract text is available yet for this article.
March 11, 2024: Journal of Pediatric Hematology/oncology
https://read.qxmd.com/read/38454568/vomiting-in-children-and-adolescents-receiving-intravenous-pegaspargase-a-retrospective-study
#30
JOURNAL ARTICLE
Jamie M Brown, Sherry Mathew, Maria Luisa Sulis, L Lee Dupuis, Jennifer Thackray
Due to an evidence gap, the emetogenicity of intravenous (IV) pegaspargase was unable to be included in the clinical practice guideline classifying chemotherapy emetogenicity in pediatric patients. This single-center, retrospective chart review describes the proportion of pediatric patients who did not vomit during the acute phase (complete response; CR) after receiving IV pegaspargase and provides an emetogenicity classification using a preexisting framework. Of 44 patients who received IV pegaspargase between 2011 and 2020, 13 received a serotonin receptor antagonist plus dexamethasone or palonosetron alone and all experienced a CR...
March 7, 2024: Pediatric Hematology and Oncology
https://read.qxmd.com/read/38449415/-ascending-colon-cancer-with-radical-resection-after-stent-reimplantation-due-to-colonic-stent-obstruction-for-palliation-a-case-report
#31
JOURNAL ARTICLE
Kensei Hanaoka, Yoshitoshi Ichikawa, Masakazu Miyake, Taro Sakurai, Takuya Inoue, Kenichi Matsumoto, Haruna Furukawa, Shigeyoshi Higashi, Ryo Tsunashima, Hirotaka Morishima, Masaki Kashiwazaki, Masahiro Tanemura
Since the insurance coverage of colorectal stents for bowel obstruction due to colorectal cancer in 2012, the use of colorectal stenting for palliation has rapidly spread. We report a case of ascending colon cancer in which a colorectal stent was placed for palliation, but the stent was reimplanted due to obstruction, followed by radical resection. The patient was a 92- year-old woman who was brought to the emergency room at the age of 90 years with repeated vomiting and abdominal pain, and was diagnosed as colorectal cancer ileus caused by ascending colon cancer, and a colorectal stent was inserted...
February 2024: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://read.qxmd.com/read/38449407/-a-case-of-left-upper-abdominal-evisceration-for-transverse-colon-cancer-with-multiple-organ-invasion
#32
JOURNAL ARTICLE
Masato Fujino, Masahiro Amano, Fumie Osuga, Masatoshi Yoshizawa, Akina Kuwahara, Satoaki Kimura, Shinichiro Usuki, Norihito Hosoi, Yukinobu Shuto, Kunihisa Miyazaki
The case is a 73-year-old woman. She visited primary care doctor for abdominal pain, vomiting, diarrhea, and melena that persisted for 2 weeks. She was referred to our department because she had an elevated inflammatory response and CT showed a mass in her left upper quadrant. Contrast-enhanced CT showed a tumorous lesion mainly in the splenic flexure of the transverse colon, involving the greater curvature of the stomach, the tail of the pancreas, and the hilus of the spleen, accompanied by abscess formation...
February 2024: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://read.qxmd.com/read/38447066/olanzapine-for-chemotherapy-induced-nausea-and-vomiting-pediatric-population-take-home-message
#33
JOURNAL ARTICLE
Alok Singh, Dhyuti Gupta
No abstract text is available yet for this article.
February 29, 2024: Journal of Pediatric Hematology/oncology
https://read.qxmd.com/read/38444575/non-hodgkin-lymphoma-in-a-kidney-transplanted-patient-with-methylmalonic-acidemia-metabolic-susceptibility-and-the-role-of-immunosuppression
#34
Alberto B Burlina, Alessandro P Burlina, Renzo Mignani, Chiara Cazzorla, Daniela Gueraldi, Andrea Puma, Christian Loro, Matthias R Baumgartner, Vincenza Gragnaniello
Methylmalonic acidemia cblB type (MMA cblB) is an autosomal recessive inborn error of amino acid metabolism that results in impaired synthesis of adenosylcobalamin, a cofactor of methylmalonyl-CoA mutase. It presents with episodes of coma, vomiting, hypotonia, metabolic acidosis, and hyperammonemia. End-stage kidney disease is a long-term complication. Treatments include vitamin B12 supplementation, L-carnitine, and a low-protein diet. Liver, kidney, or combined liver-kidney transplantations are promising options, but they are not without complications...
March 2024: JIMD Reports
https://read.qxmd.com/read/38440227/case-report-an-unusual-presentation-of-intra-abdominal-desmoplastic-small-round-cell-tumor
#35
Akshay Nilesh Desai, Christine Jane Kurian, William Rafferty, Danielle Lajoie Behrens, Polina Khrizman
BACKGROUND: Intra-abdominal desmoplastic small round cell tumor (IDSRCT) is a rare entity (0.2-0.74 cases per million people per year), which predominantly occurs in young men. It may present as an abdominal mass with pain, distention, and constipation. IDSRCT has a very poor prognosis, with 5-year overall survival estimated at 15%-30%. Diagnosis is made with tissue biopsy. CASE DESCRIPTION: We present a case of a 28-year-old man with a history of schizophrenia and depression who presented to an emergency room (ER) in November 2022 with constipation and pelvic pain...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38437957/ondansetron-attenuates-cisplatin-induced-behavioral-and-cognitive-impairment-through-downregulation-of-nod-like-receptor-inflammasome-pathway
#36
JOURNAL ARTICLE
Mennat-Allah M Hassan, Sara A Wahdan, Reem N El-Naga, Tamer M Abdelghany, Ebtehal El-Demerdash
Cisplatin is an effective and commonly used chemotherapeutic drug; however, its use is accompanied by several adverse effects, including chemobrain. Ondansetron is a 5-HT3 antagonist, commonly used in prophylactic against chemotherapy-induced nausea and vomiting. Moreover, it has been identified as a novel neuroprotective agent in different animal models. However, its protective role against chemotherapy-induced chemobrain has not been investigated. The current study was the first study that explored the potential neuroprotective effect of ondansetron against cisplatin-induced chemobrain in rats...
March 2, 2024: Toxicology and Applied Pharmacology
https://read.qxmd.com/read/38435909/neoadjuvant-chemotherapy-approach-to-pineal-germinoma-a-case-report
#37
Nagham Bazzi, Wajih A Saad, Hala Bazzi, Mohammad Ali Almokdad, Abdo Mghames
Intracranial germ cell tumors (GCTs) are rare malignant tumors with a peak incidence around puberty. The pineal region is the most commonly involved area of all intracranial GCTs. Due to the heterogeneous tumor origin, subtypes, and presentation, diagnosis and management are challenging. Complicated pineal germinomas are rarely reported in the literature. Here, we report a rare case of pineal germinoma with hydrocephalus and discuss the potential treatment approach. A 20-year-old boy presented to the hospital with vomiting and a decreased level of consciousness...
January 2024: Curēus
https://read.qxmd.com/read/38429077/pooled-analysis-of-pralatrexate-single-agent-studies-in-patients-with-relapsed-refractory-peripheral-t-cell-lymphoma
#38
JOURNAL ARTICLE
Owen A O'Connor, Bor-Sheng Ko, Ming-Chung Wang, Dai Maruyama, Yuqin Song, Ee Min Yeoh, Nick Manamley, Kensei Tobinai
Patients with relapsed or refractory (r/r) mature NK and T-cell lymphoma (MTCL) have limited treatment options. To evaluate pralatrexate's performance and factors influencing its safety and efficacy in r/r PTCL, we performed a pooled analysis of data from four similarly designed, regulatory-mandated prospective clinical trials. Of 221 patients (59 years median age; 67.0% male) in the study population, 48.9% had peripheral T-cell lymphoma not otherwise specified (PTCL-NOS), 21.3% angioimmunoblastic T-cell lymphoma, and 11...
March 1, 2024: Blood Advances
https://read.qxmd.com/read/38428877/comparison-of-efficacy-and-safety-of-5-fu-or-capecitabine-combined-with-cisplatin-and-docetaxel-mdcf-and-mdcx-as-a-first-line-chemotherapy-regimen-in-her-2-negative-metastatic-gastric-cancer-patients-a-retrospective-study
#39
JOURNAL ARTICLE
Nebi Serkan Demirci, Abdulmunir Azizy, Nail Paksoy, İzzet Doğan, Senem Karabulut, Latif Karahan, Didem Tastekin
The prognosis of metastatic gastric cancer (GC) is poor, with a median survival time of less than a year. Capecitabine is a prodrug, metabolized by thymidine phosphorylase to its cytotoxic metabolite (5-FU). Few studies have compared capecitabine and 5-FU in mGC. In this retrospective study, we compared the efficacy and safety of modified DCF (mDCF) (docetaxel, cisplatin, and 5-FU) and modified DCX (mDCX) (docetaxel, cisplatin, and capecitabine) regimens for first-line treatment in patients with mGC. The study included 112 mGC patients treated with either mDCF (n = 69) or mDCX (n = 43) between 2010 and 2021...
March 1, 2024: Medicine (Baltimore)
https://read.qxmd.com/read/38425585/efficacy-and-safety-of-oral-metronomic-chemotherapy-in-recurrent-refractory-advanced-gynaecological-cancer-an-experience-from-the-regional-cancer-centre-of-eastern-india
#40
JOURNAL ARTICLE
Ranti Ghosh, Kalyan Kusum Mukherjee, Ranajit Mandal, Tapas Maji, Debarshi Lahiri, Suparna Mazumder, Bodhisattwa Dutta, Debjit Ghosh, Jayanta Chakrabarti
INTRODUCTION: The outcome of recurrent/metastatic gynaecological malignancy has drastically improved with the introduction of poly(ADP-ribose) polymerase inhibitors and immunotherapy, but the use of these drugs in routine practice is complicated due to access barriers and their high cost in developing countries. The purpose of this study is to present the clinical response, outcome and safety of oral metronomic chemotherapy (OMCT) in resource-limited, financially constrained populations...
January 2024: Curēus
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