keyword
https://read.qxmd.com/read/6260076/the-influence-of-hypoxia-and-metabolic-inhibitors-on-the-excitation-process-in-atrioventricular-node
#21
JOURNAL ARTICLE
M Kohlhardt, K Haap
In small specimens prepared from the atrioventricular node of rabbits, the influence of hypoxia and metabolic inhibitors (Na-cyanide, 2.4 dinitrophenol, 2-desoxyglucose) on the av-node action potential was studied. The action potentials in these specimens proved to be of slow response type regardless of their origin, either the N or the NH-region of the node. 1. Following superfusion with O2-poor Tyrode solution, Vmax of the atrioventricular action potential gradually declined within 90 min and attained finally a new steady state...
November 1980: Basic Research in Cardiology
https://read.qxmd.com/read/6156034/-behavior-of-fetal-hemoglobin-during-isoelectric-focusing
#22
JOURNAL ARTICLE
J M Gulian, C Arnaud
The results of isoelectrofusing applied to haemolysates of newborns, a case of beta thalassaemia and a case of hereditary persistence of fetal haemoglobin show that fetal haemoglobin F(alpha 2 gamma 2) can be oxidized into two products. The first corresponds to fetal ferrihaemoglobin (alpha +2 gamma +2), the oxidation product of the four Fe atoms of the molecule. The second, which is called fetal intermedial methaemoglobin, and has the same pH as adult ferrihaemoglobin A1, represents probably a product of partial oxydation of fetal haemoglobin...
March 14, 1980: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://read.qxmd.com/read/4281178/metabolism-of-nitrosamines-in-vivo-ii-on-the-methylation-of-nucleic-acids-by-aliphatic-di-n-alkyl-nitrosamines-in-vivo-caused-by-beta-oxydation-the-increased-formation-of-7-methyl-guanine-after-application-of-beta-hydroxypropyl-propyl-nitrosamine-compared-to
#23
COMPARATIVE STUDY
https://read.qxmd.com/read/4145539/effects-of-17-beta-estradiol-on-the-distribution-and-activity-of-some-oxydative-enzymes-of-uterine-and-cervical-epithelium-in-neonatal-mice
#24
JOURNAL ARTICLE
A Eide, S I Mellgren
No abstract text is available yet for this article.
1973: Histochemie. Histochemistry. Histochimie
https://read.qxmd.com/read/3402384/effects-of-adenosine-triphosphate-and-alkaline-phosphatase-on-solubilized-3-5-3-triiodothyronine-binding-activity
#25
JOURNAL ARTICLE
R Faure, J H Dussault
The T3-binding activity of salt-extractable nuclear proteins from rat liver was affected when ATP (2-10 mM; pH 8.0) was added concomitantly with T3 in the incubation medium. Scatchard analysis revealed that the equilibrium association constant was significantly reduced [5 mM ATP, 0.3 +/- 0.1 (+/- SE) 10(10) M-1; control, 1.1 +/- 0.15 X 10(10) M-1], but the maximum binding capacity remained unchanged. Similar values of inhibition were obtained when unbound receptors were preincubated with ATP. ATP achieved its maximal effect after 45 min of incubation at 30 C...
September 1988: Endocrinology
https://read.qxmd.com/read/3070365/-diagnostic-procedures-in-pediatric-hypoglycemias
#26
REVIEW
U Wendel
Depending on its etiology hypoglycemia appears after short or prolonged periods of fasting and shows different metabolite and hormonal patterns. In children it is caused by a disturbed homoeostasis of blood glucose (hormonal disorders, decreased activity of glycogenolysis or gluconeogenesis), by a primarily decreased ketogenic activity, or by a deranged adjustment of ketogenesis and carbohydrate metabolism. For the diagnostic procedure the age at manifestation, periods of fasting as well as signs and symptoms (f...
September 1988: Monatsschrift Kinderheilkunde: Organ der Deutschen Gesellschaft Für Kinderheilkunde
https://read.qxmd.com/read/3036111/a-role-of-adenylate-cyclase-stimulation-in-energy-metabolism-of-reticulocytes
#27
JOURNAL ARTICLE
M M Kostic, D U Maretzki, R V Zivkovic, E G Krause, S M Rapoport
The effects of beta-adrenergic stimulation of adenylate cyclase on energy metabolism of rat reticulocytes were studied. A large initial rate of cAMP formation induced a rapid short-term stimulation of glycolysis which was followed by an exponential decline at maintained high cellular cAMP level. The decrease of glycolytic activity signifies a "metabolic desensitization" by a permanently increased cAMP concentration. Stimulation of PFK activity was found to be the main reason for the increased glycolytic rate which is due to the several fold increase of cAMP and in part to ATP-depletion...
1987: Biomedica Biochimica Acta
https://read.qxmd.com/read/2911468/psoralen-covalently-linked-to-oligodeoxyribonucleotides-synthesis-sequence-specific-recognition-of-dna-and-photo-cross-linking-to-pyrimidine-residues-of-dna
#28
JOURNAL ARTICLE
U Pieles, U Englisch
The psoralen derivative 4,5',8-trimethylpsoralen was covalently linked to the 5'-terminus of an 18mer oligodeoxyribonucleotide in the course of solid phase synthesis using phosphoroamidite chemistry. The derivative was introduced as a phosphitylation compound in the last cycle of the oligomer synthesis. The reagent was prepared by 4'-chloromethylation of 4,5',8-trimethylpsoralen, introduction of a linker by ethanediol and phosphitylation with chloro-[(beta-cyanoethoxy)-N,N-diisopropylamino]-phosphine. After oxydation and deprotection the 5'-psoralen modified oligodeoxyribonucleotide was characterised by HPLC...
January 11, 1989: Nucleic Acids Research
https://read.qxmd.com/read/2779541/intramyocardial-fate-of-15-p-iodophenyl-beta-methylpentadecanoic-acid-imppa-is-it-a-good-tracer-of-fatty-acid-myocardial-uptake
#29
COMPARATIVE STUDY
T Humbert, C Keriel, D M Batlle, C Luu-Duc, M Comet, P Cuchet
Iodinated fatty acids (FAs) are now used in Nuclear Medicine to assess, by external detection, myocardial metabolism. Methylated FAs have been proposed as tracers of FA myocardial uptake. IMPPA is a new FA analogue in which a methyl group have been introduced in beta position to inhibit beta-oxidation and a terminal phenyl group prevents a possible omega oxidation. We have compared the intramyocardial behaviour of this FA with the 15-p-iodophenyl-pentadecanoic acid (IPPA), the straight chain analogue, and with the 15-phenyl-beta-methylpentadecanoic acid (MPPA), the 3 of them being labelled with C14 on the carboxyl group, in isolated rat hearts perfused in a recirculating system...
June 27, 1989: Molecular and Cellular Biochemistry
https://read.qxmd.com/read/2776796/metabolism-of-methyl-branched-iodo-palmitic-acids-in-cultured-hepatocytes
#30
COMPARATIVE STUDY
G Thomas, D Pépin, C Loriette, M Vidal, M Apparu, S Coornaert, J Chambaz, G Béréziat
The metabolic fate of methyl-branched iodo fatty acids was studied in primary culture of rat hepatocytes. We compared 16-iodo-2-R,S-methyl palmitic acid (2-Me), which can be beta oxidized, with 16-iodo-3-R,S-methyl palmitic acid (3-Me) which can be beta oxidized only after an initial alpha oxydation and with 16-iodo-2,2-dimethyl palmitic acid (2,2-Me2) and 16-iodo-3,3-dimethyl palmitic acid (3,3-Me2) which cannot be beta oxidized at all. The normal fate of natural fatty acids was given by comparative experiments with [1-14C] palmitic acid...
1989: European Journal of Nuclear Medicine
https://read.qxmd.com/read/2757457/stimulation-of-motility-and-energy-metabolism-of-spermatozoa-from-asthenozoospermic-patients-by-17-beta-estradiol
#31
JOURNAL ARTICLE
M Idaomar, J F Guerin, J Lornage, J C Czyba
Spermatozoa from nine asthenozoospermic patients were incubated for 3 h in Krebs Phosphate Ringer (KRP), supplemented or not with 17 beta-estradiol. 17 beta-estradiol increased the mean velocity and maintained the percentage of motility during the first 2 h of incubation. Oxydative metabolism and intracellular ATP concentrations were enhanced, too, whereas glycolysis remained unchanged.
1989: Archives of Andrology
https://read.qxmd.com/read/1630076/regulation-of-membrane-phospholipid-metabolism-in-heart-cell-culture
#32
JOURNAL ARTICLE
M M Freyss-Beguin, E M Millanvoye-Van Brussel, J M Simon, D P Duval
We have isolated, from newborn rats, heart cultures enriched in contractile muscle cells (M) and cultures of fibroblast-like cells (F). M cultures respond to simulated ischemia by an arrest of beating activity, by a decrease in beta oxydation rate, ATP and phosphocreatine content and by a loss of membrane phospholipids associated with neutral lipids accumulation. F cells in contrast do not respond to oxygen deprivation. Firstly, we observed that cocultures of M and F cells respond to oxygen deprivation by an arrest of beating activity and a decrease in cellular ATP content, but failed to exhibit any significant loss of membrane phospholipids...
June 1992: Kidney International. Supplement
https://read.qxmd.com/read/1500295/sialoglycoderivatives-of-bovine-submandibular-gland-identified-in-situ-by-histochemical-techniques-combined-with-lectins
#33
JOURNAL ARTICLE
G Menghi, D Accili, P Scocco, G Materazzi
We employed sialidase procedures followed by lectin stainings combined with oxidizing and deacetylating agents to visualize the distribution and sequentiate sialoglycoconjugates in the bovine submandibular gland. In particular we evidenced in acinar and ductal cells the dishomogeneous presence of sialic acids acetylated in the polyhydroxy side chain (C7, C8, C9), whereas O-acetyl substituents at position C1 and/or C4 were not found. Sialoglycoderivatives were also differentiated by the occurrence of penultimate sugars; indeed the dimers sialic acid-(alpha 2----3,6)-beta-galactose and sialic acid-(alpha 2----6)-alpha-N-acetylgalactosamine were identified...
1992: Histochemistry
https://read.qxmd.com/read/1462730/application-of-the-metabolic-control-theory-to-the-study-of-the-dynamics-of-substrate-cycles
#34
JOURNAL ARTICLE
F Fassy, J F Hervagault, T Letellier, J P Mazat, C Reder, P Villalobos
Substrate cycles are ubiquitous structures of the cellular metabolism (e.g. Krebs cycle, fatty acids beta-oxydation cycles, etc...). Moiety-conserved cycles (e.g. adenine nucleotides and NADH/NAD, etc...) are also important. The role played by such cycles in the metabolism and its regulation is not clearly understood so far. However, it was shown that these cycles can generate multistationarity (bistability), irreversible transitions, enhancement of sensitivity, temporal oscillations and chaotic motions (Hervagault & Canu, 1987; Hervagault & Cimino, 1989; Reich & Sel'kov, 1981; Ricard & Soulié, 1982)...
September 1992: Acta Biotheoretica
https://read.qxmd.com/read/1256452/-intermittent-branched-chain-ketoacidurie-in-ketotic-hypoglycemia-investigations-to-localize-the-biochemical-defect-author-s-transl
#35
JOURNAL ARTICLE
K R Held, H J Sternowsky, S Singh, C Plettner, R Grüttner
We are reporting a girl aged eight years with ketotic hypoglycemia, mental deficiency and retarded motor and somatic development. Investigation of plasma amino acid concentrations during a spontaneous hypoglycemia revealed an increase in the branched-chain amino acids valine (4.1), leucine (7.8) and isoleucine (1.7 mg/100 ml), while alanine was decreased (1.2 mg/100 ml) and ketonuria was present. The determination of the branched-chain ketoacid decarboxylase in leukocytes showed a decrease of approximately 50% of normal for alpha-ketoisocaproic acid (KIC) as substrate, whereas values for alpha-ketoisovaleric acid (KIVA) and alpha-keto-beta-methylvaleric acid (MEVA) were normal...
February 1976: Monatsschrift Für Kinderheilkunde
https://read.qxmd.com/read/1174038/-effect-of-a-protein-free-hemoderivative-on-recovering-capability-of-rat-liver-following-60-minutes-of-hemorrhagic-shock
#36
JOURNAL ARTICLE
V R Wolff
The effect of the protein-free standardized blood extract from calves Actihaemyl on the concentration of ATP, ADP, AMP, lactate, pyruvate, beta-hydroxybutyrate, acetoacetate and glycogen of the rat liver after a 60 min hemorrhagic shock and recovery times of 30, 60 and 120 min has been investigated. Actihaemyl lowered the shock induced increased values of lactate and beta-hydroxybutyrate within the first 30 and 60 min after termination of shock at a faster rate than did the placebo. Consequently, the ratios lactate/pyruvate and beta-hydroxybutyrate/acetoacetate were found to be decreased...
March 1975: Arzneimittel-Forschung
https://read.qxmd.com/read/1083847/phosphate-ester-cleavage-in-ribose-5-phosphate-induced-by-oh-radicals-in-deoxygenated-aqueous-solution-the-effect-of-fe-ii-and-fe-iii-ions
#37
JOURNAL ARTICLE
L Stelter, C Von Sonntag, D Schulte-Frohlinde
The reaction of OH radicals and H atoms with ribose-5-phosphate (10(-2) M) in deoxygenated aqueous solution at room temperature (dose-rate 2-1 X 10(17) eV/ml-min, dose 5 X 10(18)-15 X 10(18) eV/ml) leads to the following dephosphorylation products (G-values): ribo-pentodialdose 1 (0-2), 2-hydroxy-4-oxoglutaraldehyde 2 (0-06), 5-deoxy-erythro-pentos-4-ulose 3 (0-1) and 3-oxoglutaraldehyde 4 (0-06). In addition, some minor phosphate free products (total G=0-09) are formed. G(inorganic phosphate) =1-3 and G(H2O2)=0-3...
March 1976: International Journal of Radiation Biology and related Studies in Physics, Chemistry, and Medicine
https://read.qxmd.com/read/873414/-pathogenesis-of-the-toxic-and-allergic-nephrotic-syndrome-metabolic-studies-on-kidney-cortex-slices-and-on-glomeruli
#38
JOURNAL ARTICLE
B Lamberts
The in vitro metabolism of isolated rat glomeruli in Daunomycin-nephrosis (DMS) and neophrotoxic nephritis (ANS) was determined in order to investigate questions about the nephrotic syndrome. Glomeruli of rats with Daunomycin-nephrosis influenced metabolic steps as follows: 1. Oxydative decarboxydation of pyruvate and probably also of alpha-ketoglutarate is decreased. This disturbance might be located in the formation of acetyl-and/or succinyl-CoA. 2. Incubation with pyruvate and alpha-ketoglutarat resulted in reduced oxygen uptake, and resynthesis of ATP...
May 26, 1977: Fortschritte der Medizin
https://read.qxmd.com/read/826094/-enzymhistochemical-investigations-on-the-hypothalamo-neurohypophysial-system-of-unmilked-and-milked-cows-author-s-transl
#39
JOURNAL ARTICLE
B Schneider
The behaviour of several dehydrogenases(succino-, beta-glycerophosphate-, lactate-, alcohol-, beta-hydroxibutyric acid-, glucose-6-phosphate-, isocitronic acid-dehydrogenase, monoamino-oxidase, and gamma-aminobutyric acid-transaminase) and of several hydrolytic enzymes (non-specific esterase, lipase, acetylcholin-, butyrylcholinesterase, alkaline phosphatase and leucinaminopeptidase) was investigated in the neurons of NSO and NPV, in the infundibulum and in the neurohypophysis and the innervation of the neurons (acetylcholinesterase, monoamino-oxidase, catecholamines) by unmilked and milked cows...
1976: Acta Histochemica
https://read.qxmd.com/read/486580/-influence-of-phosphatidylcholine-cholesterol-molar-ratios-in-liposomes-on-cholesterol-reactivity-with-cholesterol-oxygen-oxidoreductase
#40
JOURNAL ARTICLE
J Peynet, J Delattre, J Canal, F Rousselet, M L Girard
The reactivity of sonicated phosphatidylcholine-cholesterol liposomes with cholesterol : oxygene oxydoreductase, an enzyme which catalyses the oxidation of the 3 beta hydroxyl group of cholesterol to a ketone group, is compared with that of ternary system phosphatidylcholine-cholesterol-Thesit. Regardless to the phosphatidylcholines nature and the phosphatidylcholine/cholesterol molar ratio (R), the enzymatic oxidation rate of liposomal cholesterol is slower than when the reaction is developed in the present of Thesit, a surfactif agent which destroyes the lamellar particles...
1979: Biochimie
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