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https://www.readbyqxmd.com/read/29238723/relationship-between-malaria-and-abo-blood-types-in-east-china
#1
Xuan Zhang, Meifang Yang, Hong Zhao, Jianhua Hu, Lanjuan Li
Objectives: This study aims at investigating the relationship between malaria and blood group types in east China. Methods: Between 1 January 2011 and 31 March 2017, 99 malaria patients were enrolled for the study. Laboratory tests were conducted on their infection status and blood types. Clinical data of the participants were retrieved for analysis. Results: There was no mortality during the period of study. Overall, 90 (90.91%) of the patients were positive for Plasmodium falciparum, 8 (8...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29231762/haemolytic-anaemia-and-hepatocitolysis-associated-with-hypermagnesaemia-by-repeated-exposures-to-copper-calcium-fungicides
#2
Constantin Bălăeţ, Bogdan Ioan Coculescu, Maria Bălăeţ, Gheorghe Manole, Gabi Valeriu Dincă
For the medical practice, our manuscript acts as a signal, despite only presenting three cases which feature the association between hepatocytolysis, haemolysis and hypermagnesaemia. This clinical-biologic triad was highlighted with the workers who through the nature of their profession were exposing themselves periodically to vapours which contained copper sulphate neutralised with calcium hydroxide, a fungicide used for fruit trees. We are exclusively assessing the haematological perturbation. In this aetiological context, the generating mechanism for haemolysis is very probable biochemical, where hypercupraemia interferes with cellular antioxidant defence mechanisms...
December 2018: Journal of Enzyme Inhibition and Medicinal Chemistry
https://www.readbyqxmd.com/read/29225802/effective-immunosuppressive-management-with-belatacept-and-eculizumab-in-post-transplant-ahus-due-to-a-homozygous-deletion-of-cfhr1-cfhr3-and-the-presence-of-cfh-antibodies
#3
Johannes Münch, Anette Bachmann, Maik Grohmann, Christof Mayer, Michael Kirschfink, Tom H Lindner, Carsten Bergmann, Jan Halbritter
Atypical haemolytic uraemic syndrome (aHUS) may clinically present as acute renal graft failure resulting from excessive activation of the complement cascade. While mutations of complement-encoding genes predispose for aHUS, it is generally thought to require an additional insult (e.g. drugs) to trigger and manifest the full-blown clinical syndrome. Calcineurin inhibitors (CNIs) used for immunosuppression act as potential triggers, especially in the post-transplantation setting. Therefore, CNI-free immunosuppressive regimens may be beneficial...
December 2017: Clinical Kidney Journal
https://www.readbyqxmd.com/read/29225178/network-formation-of-moringa-oleifera-gum-by-radiation-induced-crosslinking-evaluation-of-drug-delivery-network-parameters-and-biomedical-properties
#4
Baljit Singh, Ajay Kumar
The present article is an attempt to explore the potential of the Moringa oleifera gum polysaccharides in network formation with poly(acrylic acid) by radiation induced crosslinking to develop the hydrogel for slow drug delivery applications. Polymers were characterized by Cryo-SEM, AFM and 13C NMR techniques. Furthermore, drug delivery, network formation and some biomedical properties like blood compatibility, antioxidant activity, mucoadhesion and gel strength of the hydrogels were also determined. The release of ciprofloxacin occurred through non-Fickian diffusion mechanism and release profile best fitted in Korsmeyer-Peppas kinetic model...
December 7, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29210028/antimicrobial-peptides-sourced-from-post-butter-processing-waste-yak-milk-protein-hydrolysates
#5
Jinjin Pei, Hai Jiang, Xinsheng Li, Wengang Jin, Yanduo Tao
Yak butter is one of the most important foods for the Tibetan people. Of note, its production yields waste yak milk as a by-product. In this work, waste yak milk protein hydrolysates made via Pepsin hydrolysis were shown to have antimicrobial activity. Furthermore, an innovative method of magnetic liposome adsorption combined with reversed-phase high performance liquid chromatography (RP-HPLC) was developed to screen for and purify the antimicrobial peptides. Two antimicrobial peptides were obtained and their amino acid sequences were determined by N-sequencing, namely Arg-Val-Met-Phe-Lys-Trp-Ala and Lys-Val-Ile-Ser-Met-Ile...
December 6, 2017: AMB Express
https://www.readbyqxmd.com/read/29208210/evaluation-of-the-delta-neutrophil-index-from-an-automated-blood-cell-analyser-in-septic-dogs
#6
R Troìa, C Agnoli, S Calipa, S Segalina, E Murgia, M Gruarin, F Dondi, M Giunti
Immature granulocytes (IG) are a marker of severe inflammatory states in human beings and animals, and have been linked to a diagnosis of sepsis and poor prognosis. The delta neutrophil index (DNI), automatically calculated by a haematological analyser, provides an estimate of circulating IG. In particular, an increased DNI value has been associated with the severity of sepsis, and mortality, in critically ill human beings. The aims of this study were to determine the DNI reference interval (RI) in healthy dogs, and to evaluate its diagnostic and prognostic significance in dogs with sepsis...
December 2017: Veterinary Journal
https://www.readbyqxmd.com/read/29207801/autoimmune-haemolytic-anaemia-a-spectrum-of-presentation-in-children
#7
Amitabh Singh, Anirban Mandal, Ankita Patel, Sataroopa Mishra
Autoimmune Haemolytic Anaemias (AIHAs) are rare in children. They can be either a primary disease or secondary to/triggered by a host of other clinical conditions. We present five interesting cases of paediatric AIHA associated with infections (viral, bacterial and atypical) and autoimmune diseases {Systemic Lupus Erythematosus (SLE) and Autoimmune Hepatitis (AIH)}. The H1N1 influenza associated AIHA responded to oseltamivir and Intravenous Immunoglobulin (IvIg) while the cases secondary to Mycoplasma pneumoniae and pneumococcal bacteraemia required only treatment of the primary infection...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/29207722/thalassaemia-trait-with-gaucher-disease-a-diagnostic-dilemma
#8
Jyoti Ramnath Kini, Saraswathy Sreeram, Anupama Hegde, Sowmini Kamath, Radha Ramachandra Pai
Gaucher Disease is an autosomal recessive disease caused by the accumulation of glucocerebrosidase due to deficiency in lysosomal glucocerebrosidase. Thalassaemia trait is asymptomatic and is usually an incidental diagnosis. Both thalassaemia and Gaucher disease can have similar haematologic manifestations and hence, their coexistence causes diagnostic dilemma. Our patient presented at one-and-a-half years with weakness, pallor, failure to thrive and massive hepatosplenomegaly. Clinical examination and history pointed to a lipid storage disease...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/29196175/anti-tubercular-and-probiotic-properties-of-coagulase-negative-staphylococci-isolated-from-koozh-a-traditional-fermented-food-of-south-india
#9
Ameer Khusro, Chirom Aarti, Azger Dusthackeer, Paul Agastian
In the last few years, the demand for the tremendous therapeutic applications of indigenous probiotic bacteria from diversified fermented food products has surged. In view of this, the present study was documented to evaluate the anti-tubercular and probiotic properties of coagulase-negative staphylococci (CNS) indigenous to Koozh, a traditional fermented food product of South India. A total of 18 isolates were purified from Koozh, and tested for anti-tubercular activity against Mycobacterium tuberculosis H37Rv using luciferase reporter phage (LRP) assay...
November 28, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29192961/the-incidence-and-outcome-of-clinically-significant-antibodies-detected-in-rhesus-d-positive-pregnant-women-of-the-northern-territory
#10
Lauren Andersson, Ferenc Szabo
BACKGROUND: Haemolytic disease of the fetus/newborn secondary to clinically significant non-Rhesus-D antibodies has risen in importance since the advent of immunoprophylactic anti-D administration to Rhesus-D negative women. Of interest is the incidence of these antibodies in Rhesus-D positive women, who receive less frequent antenatal alloantibody screening. This is of particular concern if the antibodies arise late in pregnancy and may go undetected. AIMS: To assess the proportion of Rhesus-D positive pregnant women with late developing clinically significant antibodies for haemolytic disease of the fetus/newborn, and whether these resulted in adverse fetal outcomes...
November 28, 2017: Australian & New Zealand Journal of Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/29188836/dissociation-of-haemolytic-and-oligomer-preventing-activities-of-gramicidin-s-derivatives-targeting-the-amyloid-%C3%AE-n-terminus
#11
Daoyuan Chen, Wenjing Qin, Gesi Wen, Bihua Shi, Ziyi Liu, Youqiao Wang, Qiang Zhou, Junmin Quan, Binhua Zhou, Xianzhang Bu
The intrinsic haemolysis of an amyloid-β (Aβ) N-terminal targeting gramicidin S derivative was successfully dissociated from its Aβ oligomer-preventing activities via Ala-scanning-based regulation of molecular amphiphilicity. The representative analogue DGR-7 shows low toxicity but significant efficiency in preventing Aβ oligomers and reducing amyloid plaques in APP/PS1 transgenic AD mice.
November 30, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29187254/acute-disseminated-melioidosis-giving-rise-to-pneumonia-and-renal-abscesses-complicated-with-thrombotic-thrombocytopenic-purpura-in-a-post-partum-woman-a-case-report
#12
Piyumi Sachindra Alwis Wijewickrama, Rohini Weerakoon
BACKGROUND: Melioidosis is an established endemic infection in Sri Lanka, caused by Burkholderia pseudomallei, a gram negative bacterium distributed in saprophytes in soil and surface water. Main mode of transmission is via percutaneous inoculation. Pneumonia is the most common presentation in acute disease. CASE PRESENTATION: We report a 33 year old previously healthy Sinhalese female with an occupational exposure to surface water in paddy fields, who was on postpartum day 6 following an uncomplicated pregnancy and delivery via an elective caesarian section...
November 29, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/29183903/cancer-related-microangiopathic-haemolytic-anaemia
#13
Anthony A Donato, Salik Nazir, Niranjan Tachamo, Daniel Forman
No abstract text is available yet for this article.
November 27, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29183554/molecular-characterisation-of-human-shiga-toxin-producing-escherichia-coli-o26-strains-results-of-an-outbreak-investigation-romania-february-to-august-2016
#14
Codruţa-Romaniţa Usein, Adriana Simona Ciontea, Cornelia Mãdãlina Militaru, Maria Condei, Sorin Dinu, Mihaela Oprea, Daniela Cristea, Valeria Michelacci, Gaia Scavia, Lavinia Cipriana Zota, Alina Zaharia, Stefano Morabito
IntroductionAt the beginning of 2016, an increase in paediatric haemolytic uremic syndrome (HUS) cases was observed in Romania. The microbiological investigations allowed isolation of Shiga toxin-producing Escherichia coli (STEC) O26 as the causative agent from most cases. Methods: An enhanced national surveillance of HUS and severe diarrhoea was established across the country following the identification of the first cases and was carried out until August 2016. A total of 15 strains were isolated from 10 HUS and five diarrhoea cases...
November 2017: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/29179636/development-and-in-vitro-in-vivo-evaluation-of-artemether-and-lumefantrine-co-loaded-nanoliposomes-for-parenteral-delivery
#15
Kashif Shakil, Sheikh Raisuddin, Sadath Ali, Syed Sarim Imam, Md Akhlaquer Rahman, Gaurav Kumar Jain, Farhan Jalees Ahmad
Combination therapy of artemether and lumefantrine is well-established for the treatment of uncomplicated malaria worldwide. Nanoliposomes encapsulating both drugs were prepared and freeze-dried. The lyophilized nanoliposomes exhibited high entrapment efficiency of artemether (66.18%), relatively low entrapment efficiency of lumefantrine (53.46%), low average size diameter (125.3 nm) and found to be stable at 4°C for 60 days without significant change in mean particle diameter and drug entrapment efficiencies...
November 27, 2017: Journal of Liposome Research
https://www.readbyqxmd.com/read/29174676/leaf-saponins-of-quillaja-brasiliensis-enhance-long-term-specific-immune-responses-and-promote-dose-sparing-effect-in-bvdv-experimental-vaccines
#16
Samuel Cibulski, Mariana Rivera-Patron, Norma Suárez, Macarena Pirez, Silvina Rossi, Anna Carolina Yendo, Fernanda de Costa, Grace Gosmann, Arthur Fett-Neto, Paulo Michel Roehe, Fernando Silveira
Saponin-based adjuvants are promising adjuvants that enhance both humoral and T-cell-mediated immunity. One of the most used natural products as vaccine adjuvants are Quillaja saponaria bark saponins and its fraction named Quil A®. Despite that, its use has been restricted for human use due to safety issues. As an alternative, our group has been studying the congener species Quillaja brasiliensis saponins and its performance as vaccine adjuvants, which have shown to trigger humoral and cellular immune responses comparable to Quil A® but with milder side effects...
November 22, 2017: Vaccine
https://www.readbyqxmd.com/read/29171663/granulocytic-anaplasmosis-in-63-dogs-clinical-signs-laboratory-results-therapy-and-course-of-disease
#17
A Chirek, C Silaghi, K Pfister, B Kohn
OBJECTIVES: To describe the clinical signs, laboratory results, therapy and course of disease in dogs with canine granulocytic anaplasmosis in which co-infections had been excluded. METHODS: Medical records of dogs naturally infected with Anaplasma phagocytophilum were retrospectively evaluated with regard to clinical signs and laboratory abnormalities at the time of presentation, therapy and course of disease. RESULTS: Nine hundred and seventy-four dogs with clinical signs suspicious for canine granulocytic anaplasmosis were tested for A...
November 24, 2017: Journal of Small Animal Practice
https://www.readbyqxmd.com/read/29169943/carboxymethylated-%C3%A9-carrageenan-conjugated-amphotericin-b-loaded-gelatin-nanoparticles-for-treating-intracellular-candida-glabrata-infections
#18
V Aparna, Anu Rohit Melge, V K Rajan, Raja Biswas, R Jayakumar, C Gopi Mohan
Intercellular Candida glabrata infections are difficult to treat due to poor penetration of drugs into the fungal niche. Delivering amphotericin B (Amp B) into the macrophages where the pathogen inhabits is an effective solution. We are studying the macrophage targeting proficiency of ɩ-carrageenan for the delivery of Amp B using gelatin A nanoparticles (GNPs). The choice of gelatin A was the outcome of in silico inspections where the amino functionalized polymer having the best docking score with Amp B was selected...
November 20, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29169004/idiopathic-atypical-haemolytic-uraemic-syndrome-presenting-with-acute-dystonia
#19
M Rizwan, K E Maduemem
Hemolytic Uremic Syndrome (HUS), a triad of microangiopathic hemolytic anemia, thrombocytopenia and acute kidney injury. The atypical HUS (aHUS) results from over activation of complement system with formation of micro thrombi and damage to endothelial cells resulting in renal impairment in 50 % and death in 25 %, commonly in untreated patients. We report an intriguing case of aHUS presenting with acute onset of movement disorder and fluctuating delirium.
August 12, 2017: Irish Medical Journal
https://www.readbyqxmd.com/read/29162867/broad-spectrum-antiviral-agents-secreted-phospholipase-a2-targets-viral-envelope-lipid-bilayers-derived-from-the-endoplasmic-reticulum-membrane
#20
Ming Chen, Chie Aoki-Utsubo, Masanori Kameoka, Lin Deng, Yutaka Terada, Wataru Kamitani, Kei Sato, Yoshio Koyanagi, Makoto Hijikata, Keiko Shindo, Takeshi Noda, Michinori Kohara, Hak Hotta
Hepatitis C virus (HCV), dengue virus (DENV) and Japanese encephalitis virus (JEV) belong to the family Flaviviridae. Their viral particles have the envelope composed of viral proteins and a lipid bilayer acquired from budding through the endoplasmic reticulum (ER). The phospholipid content of the ER membrane differs from that of the plasma membrane (PM). The phospholipase A2 (PLA2) superfamily consists of a large number of members that specifically catalyse the hydrolysis of phospholipids at a particular position...
November 21, 2017: Scientific Reports
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