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Madathipat Unnikrishnan, Sidharth Viswanathan, K Balasubramaniam, C V Muraleedharan, Arthur Vijayan Lal, P V Mohanan, Meera Mohanty, Tirur Raman Kapilamoorthy
BACKGROUND & OBJECTIVES: Vascular illnesses are on the rise in India, due to increase in lifestyle diseases and demographic transition, requiring intervention to save life, organ or limbs using vascular prosthesis. The aim of this study was to develop indigenous large diameter vascular graft for treatment of patients with vascular pathologies. METHODS: The South India Textile Research Association, at Coimbatore, Tamil Nadu, India, developed seamless woven polyester (Polyethylene terephthalate) graft at its research wing...
June 2016: Indian Journal of Medical Research
Philip Y K Pang, Jiasi Zhu, Yoong Kong Sin, Yeow Leng Chua
Most mitral paravalvular leaks (PVLs) occur during the first year after mitral valve replacement (MVR). This report describes the surgical management of 6 patients who developed very late mitral PVLs. The median interval between MVR and initial diagnosis of PVL was 16.5 years. All patients presented with congestive cardiac failure and haemolytic anaemia. The median EuroSCORE II was 9.5%. Two patients (33%) had failed attempts at transcatheter closure. Five patients underwent suture repair of the PVL. One patient underwent MVR after removal of the previous prosthesis...
September 2016: Journal of Thoracic Disease
Amal Dev D, Abraham Varghese, Sunil Mathew, P Viswanathan
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
Harshit Jain, Nikhil Gupta, Jalees Fatima, Ritu Karoli, Vaibhav Shukla
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
Marta Arczewska, Grzegorz Czernel, Mariusz Gagos
In this work, a comparative study on the effect of an antibiotic amphotericin B (AmB) and its copper complex on the multicomponent monolayers imitating the outer leaflet of human erythrocyte membrane has been performed by means of the Langmuir monolayer technique. The properties of mixed films were analysed by thermodynamic description of the interactions between the molecules, complemented with the morphology of monolayers established by Brewster Angle Microscopy (BAM). The results revealed differences in the molecular organisation of the two antibiotic forms at the air/water interface, which were explained by the different spatial structure of the complex...
October 10, 2016: Journal of Physical Chemistry. B
Diana Karpman, Sebastian Loos, Ramesh Tati, Ida Arvidsson
Haemolytic uraemic syndrome (HUS) is defined by the simultaneous occurrence of nonimmune haemolytic anaemia, thrombocytopenia and acute renal failure. This leads to the pathological lesion termed thrombotic microangiopathy, which mainly affects the kidney, as well as other organs. HUS is associated with endothelial cell injury and platelet activation, although the underlying cause may differ. Most cases of HUS are associated with gastrointestinal infection with Shiga toxin-producing enterohaemorrhagic Escherichia coli (EHEC) strains...
October 10, 2016: Journal of Internal Medicine
Vivek Sharma, Taranpreet Kaur, Helen Bridle, Moushumi Ghosh
This study evaluated five extracellular polymers of bacterial origin possessing mucoadhesive properties for their antimicrobial properties and toxicological characteristics. Of the five tested mucoadhesive biopolymers, the extracellular polymer produced by a strain of Acinetobacter haemolyticus exhibited broad antimicrobial efficacy towards Yersinia enterocolitica, Salmonella typhimurium, Listeria monocytogenes, Escherichia coli O157:H7 and Bacillus subtilis. Significant (p<0.05) inhibition of gram negative bacterial pathogens followed by gram positives were observed with the biopolymer at a dose of 40-60μg ml-1 at ambient temperature...
October 6, 2016: International Journal of Biological Macromolecules
Oddvar Oppegaard, Steinar Skrede, Haima Mylvaganam, Bård Reiakvam Kittang
BACKGROUND: Beta-haemolytic streptococci are important contributors to the global burden of osteoarticular infections (OAI). Knowledge on the disease traits specific for streptococcal OAI, however, remains scarce. We wished to explore temporal trends of OAI caused by Group A Streptococci (GAS), Group B Streptococci (GBS) and Group C and G Streptococci (GCGS), and furthermore, to describe the associated host and pathogen characteristics. METHODS: All cases of microbiologically verified β-haemolytic streptococcal OAI in Health Region Bergen, Norway, in the period 1999-2013 were retrospectively identified...
October 4, 2016: BMC Infectious Diseases
Kristina Trell, Bo Nilson, Magnus Rasmussen
beta-Haemolytic streptococci of groups C (GCS) and G (GGS) from human infections typically belong to Streptococcus dysgalactiae and are important human pathogens. Among GGS (183 isolates), several emm-types were identified without significant differences between different sites of isolation. For GCS (79 isolates), the type-distribution was markedly different and more restricted.
September 17, 2016: Diagnostic Microbiology and Infectious Disease
Parasuraman Aiya Subramani, R Vydyanath Narasimha, Ramalakshmi Balasubramanian, Venkata Ramireddy Narala, M R Ganesh, R Dinakaran Michael
Number of exotoxins like haemolysin, leukocidin, aerolysin etc. were reported from Aeromonas hydrophila. In this study, we report the haemolytic and cytotoxic effect of A. hydrophila culture supernatant (CS) that is specifically inhibited by lactose and also by serum and mucus of Nile tilapia (Oreochromis niloticus). Hence, we assume the presence of a secreted lectin in the CS. CS is toxic to peripheral blood leukocytes (PBL) of O. niloticus as revealed by MTT assay and by flow cytometry. DNA laddering assay indicates that CS causes necrosis to PBL...
October 1, 2016: Fish & Shellfish Immunology
Pablo S Corona, Frank Erimeiku, Maria Mercedes Reverté-Vinaixa, Francisco Soldado, Carles Amat, Lluis Carrera
INTRODUCTION: Necrotising fasciitis (NF) is potentially life-threatening soft-tissue infection. Early diagnosis and aggressive surgical debridement are critical to decrease mortality and morbidity. The impacts of new management technologies such as hydro-bisturi-assisted debridement (HAD) and negative pressure wound therapy (NPWT) are not yet clear with respect to treatment of NF. The objective of this study was to describe laboratory (including LRINEC score), clinical and microbiological factors, treatment methods and outcomes related to managing necrotising fasciitis, focusing on the implementation of new treatment methods in our centre...
September 2016: Injury
C S Robinson, D Timofte, E R Singer, L Rimmington, L M Rubio-Martínez
Bacterial culture and antimicrobial susceptibility testing of septic synovial samples allows instigation of targeted antimicrobial therapy; however, bacterial culture takes more than 24 h and has low sensitivity. This study aimed to identify the most frequently cultured bacteria and their antimicrobial susceptibility profile from septic synovial samples in our referral equine hospital, to allow recommendations regarding appropriate initial antimicrobial therapy prior to culture results. Hospital records for all horses with synovial sepsis and a synovial sample submitted to the microbiology laboratory between 2004 and 2013 were retrieved (n= 379 samples)...
October 2016: Veterinary Journal
Cinzia Germinario, Alfredo Caprioli, Mario Giordano, Maria Chironna, Maria Serena Gallone, Silvio Tafuri, Fabio Minelli, Antonella Maugliani, Valeria Michelacci, Luisa Santangelo, Onofrio Mongelli, Cosimo Montagna, Gaia Scavia
In summer 2013, an excess of paediatric cases of haemolytic uraemic syndrome (HUS) in a southern region of Italy prompted the investigation of a community-wide outbreak of Shiga toxin 2-producing Escherichia coli (STEC) O26:H11 infections. Case finding was based on testing patients with HUS or bloody diarrhoea for STEC infection by microbiological and serological methods. A case-control study was conducted to identify the source of the outbreak. STEC O26 infection was identified in 20 children (median age 17 months) with HUS, two of whom reported severe neurological sequelae...
September 22, 2016: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
David Huyben, Aleksandar Vidakovic, Andreas Nyman, Markus Langeland, Torbjörn Lundh, Anders Kiessling
Yeast is a potential alternative to fish meal in diets for farmed fish, yet replacing more than 50 % of fish meal results in reduced fish growth. In a 4-week experiment, 15 rainbow trout (Oncorhynchus mykiss) were cannulated and fed three diets each week: 30 % fish meal as a control (FM); 60 % replacement of fish meal protein, on a digestible basis, with Saccharomyces cerevisiae (SC); and 60 % replacement with Wickerhamomyces anomalus and S. cerevisiae mix (WA). Blood was collected at 0, 3, 6, 12 and 24 h after feeding...
September 27, 2016: Fish Physiology and Biochemistry
Sherri A Braksick, Jennifer M Martinez-Thompson, Eelco F M Wijdicks
Neurological complications of haemolytic uraemic syndrome (HUS) include altered states of consciousness, seizures, ischaemic stroke and encephalopathy. Adult-onset HUS is uncommon, and there is only a limited literature reporting neurological complications in this population. We report an adult with Shiga toxin-associated HUS complicated by focal-onset non-convulsive status epilepticus, who made a full neurological recovery.
September 26, 2016: Practical Neurology
Andrew McDowell, Emma Barnard, Jared Liu, Huiying Li, Sheila Patrick
Recently, strains of Propionibacterium acnes from the type III genetic division have been proposed as Propionibacterium acnes subsp. elongatum subsp. nov., with strains from the type I and II divisions collectively classified as Propionibacterium acnes subsp. acnes subsp. nov. Under such a taxonomic re-appraisal, we believe that types I and II should also have their own separate rank of subspecies. In support of this, we describe a polyphasic taxonomic study based on the analysis of publically available multilocus and whole genome sequence datasets, alongside a systematic review of previously published phylogenetic, genomic, phenotypic and clinical data...
September 25, 2016: International Journal of Systematic and Evolutionary Microbiology
Pratim Sengupta, Sumanta Biswas, Shiuli Chowdhury, Atish Ratan Nandi
New onset anaemia within three months after renal transplantation though not very common sometimes present as diagnostic challenge to the renal physicians. Understanding the etiology is necessary for correct management and avoiding adverse graft outcome. Passenger lymphocyte syndrome (PLS) is a rare entity of immune haemolytic anaemia that sometimes occurs in recipient of minor ABO mismatched renal transplantation. In this case report we present an AB positive renal allograft recipient who received organ from an O positive donor and developed acute haemolytic anaemia and jaundice, 19 days after renal transplantation due to PLS...
December 2015: Journal of the Association of Physicians of India
Rosanne A van Schaarenburg, Jolien Suurmond, Kim L L Habets, Mieke C Brouwer, Diana Wouters, Fina A S Kurreeman, Tom W J Huizinga, René E M Toes, Leendert A Trouw
C1q is the initiation molecule of the classical pathway of the complement system and is produced by macrophages and immature dendritic cells. As mast cells share the same myeloid progenitor cells, we have studied whether also mast cells can produce and secrete C1q. Mast cells were generated in vitro from CD34+ progenitor cells from buffy coats or cord blood. Fully differentiated mast cells were shown by both RNA sequencing and qPCR to express C1QA, C1QB and C1QC. C1q produced by mast cells has a similar molecular make-up as serum C1q...
October 2016: Molecular Immunology
N K Ahila, V Sri Ramkumar, S Prakash, B Manikandan, J Ravindran, P K Dhanalakshmi, E Kannapiran
A simple eco-friendly approach for the hasty synthesis of stable, potent and benign silver nanoparticles (AgNPs) using seagrass, Syringodium isoetifolium was proposed and described here. The UV-Vis, DLS, XRD, AFM, FESEM, EDX and HRTEM analysis highly characterized and confirmed the presence of polydispersed (2-50nm) spherical and stable AgNPs. FT-IR and phytochemical analysis suggested that the proteins act as reducing and also as capping agent. A hypothetical approach using bioinformatics tools revealed that the Phytochrome B protein of S...
September 13, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Tintu Abraham, Sujatha Sistla
INTRODUCTION: Traditionally Group A Streptococcus pyogenes (GAS) is differentiated from other beta haemolytic streptococci (BHS) by certain presumptive tests such as bacitracin sensitivity and production of Pyrollidonyl Aryl Sulfatase (PYR). The phenotypic and genotypic confirmatory tests are Lancefield grouping for cell wall carbohydrate antigen and PCR for spy1258 gene respectively. Reliance on presumptive tests alone may lead to misidentification of isolates. AIM: To compare the predictive values of routine phenotypic tests with spy1258 PCR for the identification of Streptococcus pyogenes...
July 2016: Journal of Clinical and Diagnostic Research: JCDR
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