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https://www.readbyqxmd.com/read/28073523/metabolic-and-physiological-changes-in-prymnesium-parvum-when-grown-under-and-grazing-on-prey-of-variable-nitrogen-phosphorus-stoichiometry
#1
Veronica M Lundgren, Patricia M Glibert, Edna Granéli, Nayani K Vidyarathna, Emanuela Fiori, Linjian Ou, Kevin J Flynn, Aditee Mitra, Diane K Stoecker, Per J Hansen
Mixotrophy is found in almost all classes of phytoplankton in a wide range of aquatic habitats ranging from oligotrophic to eutrophic marine and freshwater systems. Few studies have addressed how the nutritional status of the predator and/or the prey affects mixotrophic metabolism despite the realization that mixotrophy is important ecologically. Laboratory experiments were conducted to examine changes in growth rates and physiological states of the toxic haptophyte Prymnesium parvum when fed Rhodomonas salina of varying nutritional status...
May 2016: Harmful Algae
https://www.readbyqxmd.com/read/28070919/clinical-utility-of-the-basophil-activation-test-for-analysis-of-allergic-transfusion-reactions-a-pilot-study
#2
I Okamura, N Matsuyama, K Yasui, F Hirayama, T Ikeda
BACKGROUND AND OBJECTIVES: In previous studies, we demonstrated that the basophil-activating effects of supernatants found in residual-transfused platelet concentrates (PC-SNs) on whole blood basophils in cases of allergic transfusion reactions (ATRs) could be assessed by the basophil activation test (BAT) in terms of allergen/IgE dependency. However, in these studies, the basophils were derived from third-party healthy volunteers. In this study, we performed BAT using patients' own blood basophils to analyse ATRs...
January 10, 2017: Vox Sanguinis
https://www.readbyqxmd.com/read/28050380/coincidental-finding-of-beta-thalassaemia-minor-in-a-patient-of-lacquer-thinner-poisoning-presenting-as-methaemoglobinemia
#3
Charu Agarwal, Anisha Mohanpuria, Gurdeep Buxi, Vijay Kumar
Lacquer thinner, commonly used for removing household paints, is known to contain various aromatic hydrocarbons and naphtha; if ingested, may cause methaemoglobinemia. We report a case of 13-year-old girl who presented with episodes of vomiting, abdominal pain and numbness of limbs. Peripheral blood smear showed few fragmented erythrocytes and 10-12 nucleated red blood cells /100 white blood cells. Reticulocyte count was 15% with presence of Heinz bodies. There was a history of accidental ingestion of lacquer paint thinner...
November 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28043869/isolation-of-rhamnolipids-producing-cultures-from-faeces-influence-of-interspecies-communication-on-the-yield-of-rhamnolipid-congeners
#4
Marta Woźniak-Karczewska, Kamila Myszka, Agata Sznajdrowska, Alicja Szulc, Agnieszka Zgoła-Grześkowiak, Łukasz Ławniczak, Philippe F-X Corvini, Łukasz Chrzanowski
The aim of this study was to evaluate the ability of bacterial cultures isolated from cattle, poultry or pig faeces and manure to produce rhamnolipids, as well as to investigate the influence of interspecies communication on possible quantitative differences in the production of rhamnolipid congeners. Initial screening methods (oil spreading, drop collapse, haemolytic activity and emulsification activity) showed that approximately 36% of the 51 isolated cultures exhibited the ability to produce biosurfactants...
December 30, 2016: New Biotechnology
https://www.readbyqxmd.com/read/28042099/analgesic-and-anti-inflammatory-controlled-released-injectable-microemulsion-pseudo-ternary-phase-diagrams-in-vitro-ex-vivo-and-in-vivo-evaluation
#5
Isabel Pineros, Karla Slowing, Dolores R Serrano, Esther de Pablo, Maria Paloma Ballesteros
PURPOSE: Development of analgesic and anti-inflammatory controlled-released injectable microemulsions utilising lysine clonixinate (LC) as model drug and generally regarded as safe (GRAS) excipients. METHODS: Different microemulsions were optimised through pseudo-ternary phase diagrams and characterised measuring droplet size, viscosity, ex vivo haemolytic activity and in vitro drug release. The anti-inflammatory and analgesic activity was tested in mice (Hot plate test) and rats (Carrageenan-induced paw edema test) respectively and their activity was compared to an aqueous solution of LC salt...
December 29, 2016: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28036100/haemolytic-and-non-haemolytic-jaundice-revisited
#6
Michael Kaplan
I read the paper by Lee et al (1) and the accompanying editorial by Bhutani and Wong (2) with great interest. Lee et al compared risk factors in neonates with haemolytic jaundice and non-haemolytic controls. The haemolytic group comprised newborn infants with ABO blood group incompatibilities and rhesus and other red cell antibody isoimmunisations. All the other cases were classed as non-haemolytic. This article is protected by copyright. All rights reserved.
December 30, 2016: Acta Paediatrica
https://www.readbyqxmd.com/read/28012007/long-term-health-related-quality-of-life-and-psychological-adjustment-in-children-after-haemolytic-uraemic-syndrome
#7
Helene Werner, Kathrin Buder, Markus A Landolt, Thomas J Neuhaus, Guido F Laube, Giuseppina Spartà
BACKGROUND: In children after haemolytic-uraemic syndrome (HUS), little is known about long-term health-related quality of life (HRQoL) and psychological adjustment as defined by behavioural problems, depressive symptoms and post-traumatic stress symptoms. METHODS: Sixty-two paediatric patients with a history of HUS were included in this study. Medical data of the acute HUS episode were retrieved retrospectively from hospital records. Data on the clinical course at study investigation were assessed by clinical examination and laboratory evaluation...
December 23, 2016: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/28009956/new-onset-hemolytic-anemia-after-percutaneous-paravalvular-leak-closure
#8
Luís Almeida-Morais, António Fiarresga, Duarte Cacela, Lídia de Sousa, Ana Galrinho, Rui Rodrigues, Lurdes Ferreira, Rui Ferreira
BACKGROUND: Despite being usually clinically silent, paravalvular leak can present with congestive heart failure (CHF) or haemolytic anemia. Here, the case is reported of a paravalvular leak presenting with CHF, complicated by new-onset severe hemolytic anemia after percutaneous closure with a large ventricular septal duct (VSD) occlude device. METHODS: A 57-year-old patient presented with infectious endocarditis of a native mitral valve with major mitral regurgitation and was submitted for mitral valvuloplasty...
July 2016: Journal of Heart Valve Disease
https://www.readbyqxmd.com/read/28005521/characterisation-of-nasal-methicillin-resistant-staphylococcus-aureus-isolated-from-international-human-and-veterinary-surgeons
#9
Virginia Post, Llinos Harris, Mario Morgenstern, R Geoff Richards, Samuel K Sheppard, Fintan Moriarty
Nasal colonization with methicillin-resistant Staphylococcus aureus is poorly described for surgeons, despite the increased exposure to nosocomial pathogens and at-risk patients. This study investigated the molecular epidemiology and antimicrobial resistance of 26 MRSA isolates cultured from the nares of an international cross-sectional study of 1,166 human and 60 veterinary surgeons. All isolates were subjected to agr-, spa- and MLST typing and the presence of 22 virulence factors were screened for by PCR...
December 21, 2016: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28005272/prophylactic-versus-selective-blood-transfusion-for-sickle-cell-disease-in-pregnancy
#10
REVIEW
Babasola O Okusanya, Olufemi T Oladapo
BACKGROUND: Pregnant women with sickle cell disease (HbSS, HbSC and HbSβThal) may require blood transfusion to prevent severe anaemia or to manage potential medical complications. Preventive blood transfusion in the absence of complications starting from the early weeks of pregnancy or blood transfusion only for medical or obstetric indications have been used as management policies. There is currently no consensus on the blood transfusion policy that guarantees optimal clinical benefits with minimal risks for such women and their babies...
22, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28004513/simplified-serine-rich-theta-defensin-analogues-as-antitumour-peptides
#11
Paulina Strzelecka, Dominika Czaplinska, Rafal Sadej, Anna Wardowska, Michal Pikula, Adam Lesner
θ-defensins belong to the family of host defense peptides. They are the only known example of cyclic polypeptides in animal proteomes. The current study presents the synthesis of simplified θ-defensin analogues with pairs of cysteine replaced either by alanine, leucine, or serine residues. Cytotoxicity tests were performed on human mammary epithelial (HB2) and breast cancer (SKBR3, MDA-MB-231) cell lines to determine whether peptides are selectively targeting cancer cells. The effect of these peptides was also evaluated in 3D Matrigel cultures which are based on extracellular matrix components, and therefore closely represent in vivo conditions...
December 22, 2016: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/28000932/clonal-structure-in-ichthyobacterium-seriolicida-the-causative-agent-of-bacterial-haemolytic-jaundice-in-yellowtail-seriola-quinqueradiata-inferred-from-molecular-epidemiological-analysis
#12
T Matsuyama, Y Fukuda, T Sakai, N Tanimoto, M Nakanishi, Y Nakamura, T Takano, C Nakayasu
Bacterial haemolytic jaundice caused by Ichthyobacterium seriolicida has been responsible for mortality in farmed yellowtail, Seriola quinqueradiata, in western Japan since the 1980s. In this study, polymorphic analysis of I. seriolicida was performed using three molecular methods: amplified fragment length polymorphism (AFLP) analysis, multilocus sequence typing (MLST) and multiple-locus variable-number tandem repeat analysis (MLVA). Twenty-eight isolates were analysed using AFLP, while 31 isolates were examined by MLST and MLVA...
December 21, 2016: Journal of Fish Diseases
https://www.readbyqxmd.com/read/27999062/5-hydroxyethyl-3-tetradecanoyltetramic-acid-represents-a-novel-treatment-for-intravascular-catheter-infections-due-to-staphylococcus-aureus
#13
Marta Zapotoczna, Ewan J Murray, Siobhan Hogan, James P O'Gara, Siri R Chhabra, Weng C Chan, Eoghan O'Neill, Paul Williams
OBJECTIVES: Biofilm infections of intravascular catheters caused by Staphylococcus aureus may be treated with catheter lock solutions (CLSs). Here we investigated the antibacterial activity, cytotoxicity and CLS potential of 5-hydroxyethyl-3-tetradecanoyltetramic acid (5HE-C14-TMA) compared with the related compounds 3-tetradecanoyltetronic (C14-TOA) and 3-tetradecanoylthiotetronic (C14-TTA), which are variants of quorum sensing signalling molecules produced by Pseudomonas aeruginosa METHODS: Antibacterial activity and mechanism of action of 5HE-C14-TMA, C14-TOA and C14-TTA were determined via MIC, bacterial killing, membrane potential and permeability assays...
December 20, 2016: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/27992168/feasibility-study-exploring-the-potential-of-novel-battacin-lipopeptides-as-antimicrobial-coatings
#14
Gayan Heruka De Zoysa, Vijayalekshmi Sarojini
Colonization of medical implant surfaces by pathogenic microorganisms causes implant failure and undermines their clinical applicability. Alarming increase in multidrug-resistant bacteria poses serious concerns with the use of medical implants. Antimicrobial peptides (AMPs) that form part of the innate immune system in all forms of life are attractive alternatives to conventional antibiotics to treat multidrug-resistant bacterial biofilms. The aim of this study was to assess the in vitro antibacterial potency of our recently discovered lipopeptides from the battacin family upon immobilization to various surfaces...
January 4, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27991739/paediatric-hus-cases-related-to-the-consumption-of-raw-milk-sold-by-vending-machines-in-italy-quantitative-risk-assessment-based-on-escherichia-coli-o157-official-controls-over-7%C3%A2-years
#15
F Giacometti, P Bonilauri, S Piva, G Scavia, S Amatiste, D M Bianchi, M N Losio, S Bilei, G Cascone, D Comin, P Daminelli, L Decastelli, G Merialdi, R Mioni, A Peli, A Petruzzelli, F Tonucci, G Liuzzo, A Serraino
A quantitative risk assessment (RA) was developed to estimate haemolytic-uremic syndrome (HUS) cases in paediatric population associated with the consumption of raw milk sold in vending machines in Italy. The historical national evolution of raw milk consumption phenomenon since 2008, when consumer interest started to grow, and after 7 years of marketing adjustment, is outlined. Exposure assessment was based on the official Shiga toxin-producing Escherichia coli O157:H7 (STEC) microbiological records of raw milk samples from vending machines monitored by the regional Veterinary Authorities from 2008 to 2014, microbial growth during storage, consumption frequency of raw milk, serving size, consumption preference and age of consumers...
December 19, 2016: Zoonoses and Public Health
https://www.readbyqxmd.com/read/27990116/combined-acute-haemolytic-and-secondary-angle-closure-glaucoma-following-spontaneous-intraocular-haemorrhages-in-a-patient-on-warfarin
#16
Walter Andreatta, Stavroula Boukouvala, Atul Bansal
BACKGROUND: To report the first described case of combined haemolytic and acute angle closure glaucoma secondary to spontaneous intraocular haemorrhages in a patient on excessive anticoagulation. To the best of our knowledge, this is the first case reported in the literature presenting with raised intraocular pressure due to both mechanisms. CASE DESCRIPTION: A 90-year-old woman presented with acute pain and reduction in vision in the left eye. Her intraocular pressure (IOP) was 55 mm Hg...
September 2016: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/27984143/delineating-residues-for-haemolytic-activities-of-snake-venom-cardiotoxin-1-from-naja-naja-as-probed-by-molecular-dynamics-simulations-and-in-vitro-validations
#17
Biswajit Gorai, Thirunavukkarasu Sivaraman
Cardiotoxins (CTXs) are single polypeptide chain consisting of 59-62 amino acids with four disulfide bridges and globular proteins of simple β-sheet folds. The CTXs are one of principal toxic components causing haemolysis and damaging various cells and belong to three-finger toxin (TFT) superfamily of snake venoms. However, there is no natural or synthetic small molecular inhibitor to the protein toxins to date. In the present study, modes of interaction of cardiotoxin 1 (CTX1) from Indian cobra (Naja naja) with heterogeneous erythrocyte membrane (EM) model system have been extensively examined by using all-atom molecular dynamics (MD) simulations in near physiological conditions and comprehensive analyses of the MD data revealed two distinct principal regions ('head groove' and 'loop groove') of the protein toxin for establishing structural interactions with the EM system...
February 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/27979847/concomitant-multiple-myeloma-gastric-adenocarcinoma-and-evan-s-syndrome-in-a-patient-presenting-with-anaemia
#18
Maged Al-Ammari, Soheir Adam
An association between multiple myeloma (MM) and solid tumours has been previously described.(1) Furthermore, autoimmune disorders can precede plasma cell dyscrasias, and the pathogenesis of MM maybe linked to chronic immune stimulation. (2) We describe a case of concomitant MM and gastric adenocarcinoma preceded by Evan's syndrome. A previously healthy woman presented to the emergency room with symptomatic anaemia. Her initial workup was compatible with autoimmune haemolytic anaemia and monoclonal gammopathy of undetermined significance...
December 15, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27979843/unexplained-lymphadenopathies-autoimmune-lymphoproliferative-syndrome-in-an-adult-patient
#19
Fatima Leal-Seabra, Gonçalo Sarmento Costa, Henrique Pereira Coelho, Agripino Oliveira
Autoimmune lymphoproliferative syndrome (ALPS) is characterised by massive enlargement of the lymphoid organs, autoimmune cytopenias and a predisposition to develop lymphoid malignancies. The basic defect is a disturbance of the lymphocyte apoptosis, and a high number of circulating TCRab CD3(+)CD4(-)CD8(-) T-cells (double-negative T cells (DNT cells)). We describe a case of a 41-year-old man with fever, hepatosplenomegaly, multiple lymphadenopathy, autoimmune haemolytic anaemia and severe thrombocytopenia...
December 15, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27965652/identification-and-characterization-of-novel-compounds-blocking-shiga-toxin-expression-in-escherichia-coli-o157-h7
#20
Alejandro Huerta-Uribe, Zoe R Marjenberg, Nao Yamaguchi, Stephen Fitzgerald, James P R Connolly, Nuria Carpena, Hanna Uvell, Gillian Douce, Michael Elofsson, Olwyn Byron, Rudi Marquez, David L Gally, Andrew J Roe
Infections caused by Shiga toxin (Stx)-producing E. coli strains constitute a health problem, as they are problematic to treat. Stx production is a key virulence factor associated with the pathogenicity of enterohaemorrhagic E. coli (EHEC) and can result in the development of haemolytic uremic syndrome in infected patients. The genes encoding Stx are located on temperate lysogenic phages integrated into the bacterial chromosome and expression of the toxin is generally coupled to phage induction through the SOS response...
2016: Frontiers in Microbiology
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