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JOURNAL ARTICLE
Emmanuel Ikechukwu Okaforcha, George Uchenna Eleje, Joseph Ifeanyichukwu Ikechebelu, Chukwuemeka Okwudili Ezeama, Emeka Philip Igbodike, Emmanuel Onyebuchi Ugwu, Boniface Chukwuneme Okpala, Ikechukwu Innocent Mbachu, Osita Samuel Umeononihu, Chukwudi Anthony Ogabido, Daniel Nnaemeka Onwusulu, Charlotte Blanche Oguejiofor, Chidinma Charity Okafor, Chinedu Lawrence Olisa, David Chibuike Ikwuka, Ifeanyichukwu Jude Ofor, Chigozie Geoffrey Okafor
OBJECTIVES: To compare the efficacy and safety of intravenous and intramuscular oxytocin in preventing atonic primary postpartum haemorrhage in the third stage of labour. METHODS: A double-blind randomised clinical study on consenting women without risk factors for primary postpartum haemorrhage in labour at term. Two hundred and thirty-two women were randomly allotted into intravenous ( n = 115) and intramuscular ( n = 117) oxytocin groups in the active management of the third stage of labour...
2024: SAGE Open Medicine
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JOURNAL ARTICLE
Nathalia G Amado, Elena D Nosyreva, David Thompson, Thomas J Egeland, Osita W Ogujiofor, Michelle Yang, Alexandria N Fusco, Niccolo Passoni, Jeremy Mathews, Brandi Cantarel, Linda A Baker, Ruhma Syeda
Prune belly syndrome (PBS), also known as Eagle-Barret syndrome, is a rare, multi-system congenital myopathy primarily affecting males. Phenotypically, PBS cases manifest three cardinal pathological features: urinary tract dilation with poorly contractile smooth muscle, wrinkled flaccid ventral abdominal wall with skeletal muscle deficiency, and intra-abdominal undescended testes. Genetically, PBS is poorly understood. After performing whole exome sequencing in PBS patients, we identify one compound heterozygous variant in the PIEZO1 gene...
January 6, 2024: Nature Communications
#3
JOURNAL ARTICLE
Stephen P H Alexander, Eamonn Kelly, Alistair A Mathie, John A Peters, Emma L Veale, Jane F Armstrong, O Peter Buneman, Elena Faccenda, Simon D Harding, Michael Spedding, John A Cidlowski, Doriano Fabbro, Anthony P Davenport, Jörg Striessnig, Jamie A Davies, Katelin E Ahlers-Dannen, Mohammed Alqinyah, Thiruma V Arumugam, Christopher Bodle, Josephine Buo Dagner, Bandana Chakravarti, Shreoshi P Choudhuri, Kirk M Druey, Rory A Fisher, Kyle J Gerber, John R Hepler, Shelley B Hooks, Havish S Kantheti, Behirda Karaj, Somayeh Layeghi-Ghalehsoukhteh, Jae-Kyung Lee, Zili Luo, Kirill Martemyanov, Luke D Mascarenhas, Harrison McNabb, Carolina Montañez-Miranda, Osita Ogujiofor, Hoa Phan, David L Roman, Vincent Shaw, Benita Sjogren, Christopher Sobey, Mackenzie M Spicer, Katherine E Squires, Laurie Sutton, Menbere Wendimu, Thomas Wilkie, Keqiang Xie, Qian Zhang, Yalda Zolghadri
The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and about 6000 interactions with about 3900 ligands. There is an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target and ligand properties...
October 2023: British Journal of Pharmacology
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JOURNAL ARTICLE
Oluwafemi Adeleke Ojo, Abayomi Emmanuel Adegboyega, Odunayo Anthonia Taiwo, Christopher Busayo Olowosoke, Grace Inioluwa Johnson, Ngozi Lillian Umedum, Kingsley Onuh, Mary Nneka Adeduro, Valentine Osita Nwobodo, Ayodele O Elekan, Taiwo Emmanuel Alemika, Titilayo Omolara Johnson
Protein tyrosine phosphatase 1B (PTP1B) has been identified as a promising drug target for the development of diabetes medications via an inhibition mechanism. Using a computational approach, this study investigates the binding mechanism of lead optimized natural compounds from Allium sativum against the human PTP1B. The molecular docking, induced-fit docking, and binding free energy calculations were analyzed using Schrödinger Suite 2021-2. MD simulation, and gene enrichment analysis was achieved via the Desmond module of Schrödinger to identify best compounds as inhibitors against PTP1B in diabetes management...
December 18, 2023: Journal of Biomolecular Structure & Dynamics
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JOURNAL ARTICLE
Ifeyinwa L Ezenwosu, Justus U Onu, Uchenna V Chukwuma, Chima Onwuka-Kalu, Olusegun F Omotola, Osita U Ezenwosu, Chinwe J Chukwuka
OBJECTIVES: The use of antiretroviral drugs among HIV-infected adolescents has been challenged with poor medication adherence, leading to an unsuppressed viral load and ultimately to drug resistance. Recently, dolutegravir has been approved for use in adolescents with HIV, but the evidence on medication adherence and viral load suppression is limited. The study determined the effect of dolutegravir-based drug regimens on the level of medication adherence and viral load among treatment-experienced adolescents...
December 8, 2023: International Journal of Adolescent Medicine and Health
#6
JOURNAL ARTICLE
Charlotte Blanche Oguejiofor, Kenechi Miracle Ebubechukwu, George Uchenna Eleje, Emmanuel Onyebuchi Ugwu, Joseph Tochukwu Enebe, Kingsley Emeka Ekwuazi, Chukwuemeka Chukwubuikem Okoro, Boniface Chukwuneme Okpala, Charles Chukwunomunso Okafor, Nnanyelugo Chima Ezeora, Emeka Ifeanyi Iloghalu, Chidebe Christian Anikwe, Chigozie Geoffrey Okafor, Polycarp Uchenna Agu, Emeka Philip Igbodike, Iffiyeosuo Dennis Ake, Arinze Anthony Onwuegbuna, Osita Samuel Umeononihu, Onyedika Promise Anaedu, Odigonma Zinobia Ikpeze, David Chibuike Ikwuka, Henry Ifeanyi Nwaolisa, Ekene Agatha Emeka, Jude Ogechukwu Okoye, Ihechinyerem Kelechi Osuagwu, Angela Ogechukwu Ugwu, Toochukwu Benjamin Ejikeme, Eziamaka Pauline Ezenkwele, Chijioke Ogomegbunam Ezeigwe, Malarchy Ekwunife Nwankwo, Gerald Okanandu Udigwe, Joseph Ifeanyichukwu Ikechebelu, Grace Agbaeze, Chukwuebuka Divine Nwanja, Ahizechukwu Chigoziem Eke
BACKGROUND AND OBJECTIVES: Coronavirus disease 2019 (COVID-19) is a pandemic that has become a major source of morbidity and mortality worldwide, affecting the physical and mental health of individuals influencing reproduction. Despite the threat, it poses to maternal health in sub-Saharan Africa and Nigeria, there is little or no data on the impact it has on fertility, conception, gestation and birth. To compare the birth rate between pre-COVID and COVID times using selected months of the year...
February 25, 2023: Infect Dis Res
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JOURNAL ARTICLE
Justin A Olivera, Isaac Faith, Osita Onugha
Indocyanine green (ICG) is a water-soluble molecule that emits fluorescence in the near-infrared light spectrum. Due to its fluorescence properties, safety profile, and cost-effectiveness, ICG is used in minimally invasive surgery, enabling real-time visualization of structures during the operation. Until recently, its use was mainly limited to robotic surgery, which required specific technological setups to visualize the fluorescence. With recent technological advancements, however, similar capabilities can now be integrated into smaller laparoscopic instruments, broadening the accessibility and usefulness of ICG...
November 16, 2023: Surgical Technology International
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REVIEW
Chiedu Eseadi, Amos Nnaemeka Amedu, Leonard Chidi Ilechukwu, Millicent O Ngwu, Osita Victor Ossai
Diabetes is a non-communicable ailment that has adverse effects on the individual's overall well-being and productivity in society. The main objective of this study was to examine the empirical literature concerning the association between diabetes and poverty and the accessibility and utilization of medical care services among diabetic patients. The diabetes literature was explored using a literature review approach. This review revealed that diabetes is an ailment that affects all individuals irrespective of socioeconomic status; however, its pre-valence is high in low-income countries...
October 15, 2023: World Journal of Diabetes
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REVIEW
Stephen C Emencheta, Chinasa V Olovo, Osita C Eze, Chisom F Kalu, Dinebari P Berebon, Ebele B Onuigbo, Marta M D C Vila, Victor M Balcão, Anthony A Attama
Bacteriophages (phages) are nano-sized viruses characterized by their inherent ability to live off bacteria. They utilize diverse mechanisms to absorb and gain entry into the bacterial cell wall via the release of viral genetic material, which uses the replication mechanisms of the host bacteria to produce and release daughter progeny virions that attack the surrounding host cells. They possess specific characteristics, including specificity for particular or closely related bacterial species. They have many applications, including as potential alternatives to antibiotics against multi-resistant bacterial pathogens and as control agents in bacteria-contaminated environments...
October 3, 2023: Pharmaceutics
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JOURNAL ARTICLE
Chukwuemeka C Okoro, Okechukwu C Ikpeze, George U Eleje, Gerald O Udigwe, Chukwuemeka O Ezeama, Joseph O Ugboaja, Chukwunonso I Enechukwu, Osita S Umeononihu, Chukwudi A Ogabido, Charlotte Oguejiofor, Tobechi Njoku, Richard O Egeonu, Chigozie Okafor, Hillary I Obiagwu, Chukwudubem C Onyejiaka, Afam B Obidike, Christian E Onah, Ifeanyi Uzukwu, Amarachukwu D Okoro, Evaristus C Ezema, Adaobi Ibekwe, Joseph I Ikechebelu
OBJECTIVE: Uterine leiomyoma is a common gynecological condition that negatively affects women's quality of life. Vitamin D plays an important role in tumor development and progression. However, clinical studies comparing serum vitamin D levels between women with and without uterine leiomyomas are limited and inconclusive. This study aimed to compare serum vitamin D levels in women with and without uterine leiomyomas. METHODS: This hospital-based case-control study included 150 women who visited a gynecological clinic...
October 17, 2023: Obstetrics & Gynecology Science
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JOURNAL ARTICLE
Osita Ede, Oke R Obadaseraye, Ifeanyi Anichi, Chisom Mbaeze, Chukwuka O Udemezue, Chinonso Basil-Nwachuku, Kenechi A Madu, Emmanuel C Iyidobi, Udo E Anyaehie, Cajetan U Nwadinigwe, Chidinma Ngwangwa, Uto Essien Adetula
Preoperative informed consent is a legal and ethical requirement that ensures patients understand a procedure, its associated risks and benefits, alternative treatment options, and potential complications to make an informed decision about their care. This cross-sectional study evaluated the informed consent process for major orthopaedic surgeries at a tertiary hospital in Nigeria. A self-administered questionnaire was used to collect data from 120 adult participants. Results showed that many patients do not read the consent form before signing it, and surgeons do not adequately explain the alternatives to surgery, potential risks, and available anaesthetic options...
October 9, 2023: Developing World Bioethics
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JOURNAL ARTICLE
Ursula Adams, Jaclyn Portelli Tremont, Avital Yohann, Joshua Aldridge, Stephanie Riggins, Michelle Brownstein, Anthony Charles, Pascal Osita Udekwu
BACKGROUND: Prevention of chronic disease necessitates early diagnosis and intervention. In young adults, a trauma admission may be an early contact with the healthcare system, representing an opportunity for screening and intervention. This study estimates the prevalence of previously diagnosed (PD) and undiagnosed (UD) disease - diabetes (DM), hypertension (HTN), obesity, and alcohol and substance use - in a young adult trauma population. We determine factors associated with UD and examine outcomes in patients with UD...
October 3, 2023: Journal of Trauma and Acute Care Surgery
#13
JOURNAL ARTICLE
Obinna Osita Ike, Lawrence Ejike Ugwu, Ibeawuchi K Enwereuzor, Ifeanyichukwu Chukwudi Eze, Obiageli Omeje, Ejike Okonkwo
BACKGROUND: This study aims to provide researchers and practitioners with a more elaborate instrument to measure turnover intentions based on the planned behaviour theory model. The questionnaire assesses 5 distinct aspects of turnover intentions (i.e., subjective social status, organisational culture, personal orientation, expectations, and career growth). METHODS: In this cross-sectional study (comprise of 2 studies in one) a wave survey design was applied to a large diversity of workers drawn from the staff of universities, banks, hospitals, factories, and telecommunication companies...
September 11, 2023: BMC Psychology
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JOURNAL ARTICLE
Osita Sunday Nnyigide, Kyu Hyun
We report the gelation of mixed proteins consisting of oppositely charged lysozyme and serum albumins at various pH. The results from rheological tests showed that at a pH of 7, the gelation temperature (Tgel ) of the oppositely charged proteins was lower than the melting temperature (Tm ) of the individual protein. To ascertain the conformational state of the proteins at the observed Tgel , the attenuated total-reflectance Fourier-transform infrared (ATR-FTIR) spectra of the proteins were acquired. The recorded spectra showed that the proteins were predominantly alpha helical, suggesting that the observed gelation was electrostatically triggered...
August 27, 2023: Colloids and Surfaces. B, Biointerfaces
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JOURNAL ARTICLE
Charles Amarachi Ogbu, Tatiana Alexiou Ivanova, Temitayo Abayomi Ewemoje, Chinedu Osita Okolie, Hynek Roubik
Waste management has been a chronic environmental challenge in Nigeria, coupled with declining economic performance due to energy crises. This study was designed to estimate electricity potential of sewage sludge to meet the 2030 Renewable Energy target. However, there was a need to fill the gap in data related to wastewater management in Nigeria. The wastewater and sludge generated from households were evaluated based on data on population, access to water, and coverage of sewer networks. Consequently, the technical and economic feasibility of electricity generation was assessed using Anaerobic Digestion (AD)1 and Incineration (INC)2 scenarios...
August 24, 2023: Science of the Total Environment
#16
REVIEW
Osita C Eze, Dinebari P Berebon, Stephen C Emencheta, Somtochukwu A Evurani, Chibundo N Okorie, Victor M Balcão, Marta M D C Vila
Due to the increasing limitations and negative impacts of the current options for preventing and managing diseases, including chemotherapeutic drugs and radiation, alternative therapies are needed, especially ones utilizing and maximizing natural products (NPs). NPs abound with diverse bioactive primary and secondary metabolites and compounds with therapeutic properties. Marine probiotics are beneficial microorganisms that inhabit marine environments and can benefit their hosts by improving health, growth, and disease resistance...
August 1, 2023: Pharmaceuticals
#17
JOURNAL ARTICLE
Ifeyinwa Lilian Ezenwosu, Osita Uchenna Ezenwosu
BACKGROUND: Integrating nutrition interventions which include nutrition education in HIV/AIDS care program may help people living with HIV/AIDS (PLWHA) make better decisions regarding their nutrition to improve their immune system. OBJECTIVE: To determine the effect of nutrition education on dietary diversity among HIV/AIDS patients in Southeast, Nigeria. METHODS: A quasi-experimental study was conducted among 370 HIV patients divided into two groups of 185 each for the study and control groups...
March 2023: African Health Sciences
#18
REVIEW
George Uchenna Eleje, Olabisi Morebise Loto, Hadiza Abdullahi Usman, Chinyere Ukamaka Onubogu, Preye Owen Fiebai, Godwin Otuodichinma Akaba, Ayyuba Rabiu, Ikechukwu Innocent Mbachu, Moriam Taiwo Chibuzor, Rebecca Chinyelu Chukwuanukwu, Ngozi Nneka Joe-Ikechebelu, Emeka Philip Igbodike, Richard Obinwanne Egeonu, Ijeoma Chioma Oppah, Uchenna Chukwunonso Ogwaluonye, Chike Henry Nwankwo, Stephen Okoroafor Kalu, Chisom God'swill Chigbo, Chukwuanugo Nkemakonam Ogbuagu, Shirley Nneka Chukwurah, Chinwe Elizabeth Uzochukwu, Aishat Ahmed, Chiamaka Henrietta Jibuaku, Samuel Oluwagbenga Inuyomi, Bukola Abimbola Adesoji, Ubong Inyang Anyang, Ekene Agatha Emeka, Odion Emmanuel Igue, Ogbonna Dennis Okoro, Prince Ogbonnia Aja, Chiamaka Perpetua Chidozie, Hadiza Sani Ibrahim, Fatima Ele Aliyu, Harrison Chiro Ugwuoroko, Aisha Ismaila Numan, Solace Amechi Omoruyi, Osita Samuel Umeononihu, Chukwuemeka Chukwubuikem Okoro, Ifeanyi Kingsley Nwaeju, Arinze Anthony Onwuegbuna, Lydia Ijeoma Eleje, David Chibuike Ikwuka, Eric Okechukwu Umeh, Sussan Ifeyinwa Nweje, Ifeoma Clara Ajuba, Angela Ogechukwu Ugwu, Uzoamaka Rufina Ebubedike, Divinefavour Echezona Malachy, Chigozie Geoffrey Okafor, Nnaedozie Paul Obiegbu, Emmanuel Onyebuchi Ugwu, Ibrahim Adamu Yakasai, Oliver Chukwujekwu Ezechi, Joseph Ifeanyichukwu Ikechebelu
OBJECTIVE: We systematically identified the prevalence of triplex infections (combined human immunodeficiency virus (HIV), hepatitis B virus (HBV), and hepatitis C virus (HCV)) in pregnancy. METHODS: To gather information on the frequency of triplex infections, we searched the databases of PubMed, CINAHL, and Google Scholar. Without regard to language, we utilized search terms that covered HIV, HBV, HCV, and pregnancy. Pregnant women with triplex infections of HIV, HBV, and HCV were included in studies that also examined the prevalence of triplex infections...
2023: Obstetrics and Gynecology International
#19
JOURNAL ARTICLE
Eric Ng'eno, Margaret Lind, Allan Audi, Alice Ouma, Clifford Oduor, Patrick K Munywoki, George O Agogo, George Odongo, Samuel Kiplangat, Newton Wamola, Mike Powel Osita, Robert Mugoh, Caroline Ochieng, Victor Omballa, Ondari D Mogeni, Matthew Mikoleit, Barry S Fields, Joel M Montgomery, Jillian Gauld, Robert F Breiman, Bonventure Juma, Elizabeth Hunsperger, Marc-Alain Widdowson, Godfrey Bigogo, Eric D Mintz, Jennifer R Verani
Typhoid fever burden can vary over time. Long-term data can inform prevention strategies; however, such data are lacking in many African settings. We reexamined typhoid fever incidence and antimicrobial resistance (AMR) over a 10-year period in Kibera, a densely populated urban informal settlement where a high burden has been previously described. We used data from the Population Based Infectious Diseases Surveillance platform to estimate crude and adjusted incidence rates and prevalence of AMR in nearly 26,000 individuals of all ages...
May 30, 2023: American Journal of Tropical Medicine and Hygiene
#20
JOURNAL ARTICLE
Charlotte B Oguejiofor, Chidimma D Okafor, George U Eleje, Joseph I Ikechebelu, Chigozie G Okafor, Joseph O Ugboaja, Chukwudi A Ogabido, Tobechi K Njoku, Osita S Umeononihu, Boniface C Okpala, Malarchy E Nwankwo, Chijioke O Ezeigwe, Chukwunonso I Enechukwu, Ahizechukwu C Eke
BACKGROUND: Pregnancies complicated with antepartum-haemorrhage is high risk pregnancies associated with adverse maternal, fetal-and-perinatal-outcomes. It contributes significantly to fetal and maternal mortality especially in the developing countries. Proper antenatal care and prompt intervention is necessary to forestall adverse and improve outcome. OBJECTIVE: To determine the prevalence, sociodemographic characteristics, risk factors, fetomaternal outcome of pregnancies with antepartum haemorrhage...
March 2023: International journal of innovative research in medical science
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