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https://www.readbyqxmd.com/read/29791705/is-there-a-role-for-vats-sleeve-lobectomy-in-lung-cancer
#1
Natalie N Merchant, Robert McKenna, Osita Onugha
Lung cancer is the second most commonly diagnosed cancer and continues to be the leading cause of death for both men and women, with non-small cell lung cancer (NSCLC) accounting for 85% of all lung cancer cases. Once a lung mass is visualized on imaging, accurate staging is required for determination of treatment options and, when possible, surgical resection is recommended as it has been proven to have the best survival rates versus non-surgical treatment. If a patient has advanced or metastatic disease, therapeutic options include chemotherapy and radiation, while immunotherapy and specific agents that target tumor mutations are only recommended for appropriate candidates...
June 1, 2018: Surgical Technology International
https://www.readbyqxmd.com/read/29621178/assessment-of-the-pro12ala-polymorphism-in-the-ppar-%C3%AE-2-gene-among-type-2-diabetes-patients-in-a-nigerian-population
#2
Godwill Azeh Engwa, Friday Nweke Nwalo, Venatus Osita Chiezey, Marian N Unachukwu, Opeolu Oyejide Ojo, Benjamin Ewa Ubi
The association between the Pro12Ala polymorphism of the PPARγ2 gene, type 2 diabetes (T2D), and obesity in certain ethnic populations has been reported. However, this relationship has not yet been described among diabetes patients in Nigeria. This study investigated the relationship between the Pro12Ala polymorphism in the PPARγ2 gene, obesity, and lipid abnormalities characterizing T2D among patients in Nigeria. This case-control study recruited 73 T2D and 75 non-diabetic (ND) patients. Demographic and clinical data were collected and blood glucose levels together with serum lipid profile for patients were measured...
April 5, 2018: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/29562242/factors-associated-with-inadequate-receipt-of-components-and-use-of-antenatal-care-services-in-nigeria-a-population-based-study
#3
Kingsley E Agho, Osita K Ezeh, Felix A Ogbo, Anthony I Enoma, Camille Raynes-Greenow
Background: Antenatal care (ANC) is an essential intervention to improve maternal and child health. In Nigeria, no population-based studies have investigated predictors of poor receipt of components and uptake of ANC at the national level to inform targeted maternal health initiatives. This study aimed to examine factors associated with inadequate receipt of components and use of ANC in Nigeria. Methods: The study used information on 20 405 singleton live-born infants of the mothers from the 2013 Nigeria Demographic and Health Survey...
March 19, 2018: International Health
https://www.readbyqxmd.com/read/29497866/exploring-the-differences-and-similarities-between-urea-and-thermally-driven-denaturation-of-bovine-serum-albumin-intermolecular-forces-and-solvation-preferences
#4
Osita Sunday Nnyigide, Sun-Gu Lee, Kyu Hyun
The interactions of bovine serum albumin (BSA) with urea/water were investigated by computer simulation. It was revealed that the BSA-hydrophobic residues in urea solutions favored contact with urea more than with water. Energy decomposition analysis showed that van der Waals energy was the dominant driving force behind urea affinity for hydrophobic residues, whereas coulombic attraction was largely responsible for water affinity for these residues. Meanwhile, urea-BSA hydrogen bond energies were found to be weaker than water-BSA hydrogen bond energies...
March 1, 2018: Journal of Molecular Modeling
https://www.readbyqxmd.com/read/29226219/systematic-optimization-and-modification-of-a-dna-aptamer-with-2-o-methyl-rna-analogues
#5
George Maio, Osita Enweronye, Hasan E Zumrut, Sana Batool, Nabeela Van, Prabodhika Mallikaratchy
Nucleic acid aptamers (NAAs) are short synthetic DNA or RNA molecules that specifically fold into distinct three-dimensional structures able to specifically recognize a target. While NAAs show unprecedented promise in a variety of applications, including sensing, therapeutics and diagnostics, one major limitation involves the lack of stability towards omnipresent nucleases. Therefore, we herein report a systematic truncation and incorporation of 2'-O-methyl bases to a DNA aptamer, which results in increased stability without affecting affinity...
March 1, 2017: ChemistrySelect
https://www.readbyqxmd.com/read/29078651/is-there-a-role-for-video-assisted-thoracic-surgery-in-chest-wall-surgery
#6
EDITORIAL
Osita Onugha
No abstract text is available yet for this article.
2017: Journal of visualized surgery
https://www.readbyqxmd.com/read/28980209/la-sota-vaccination-may-not-protect-against-virus-shedding-and-the-lesions-of-velogenic-newcastle-disease-in-commercial-turkeys
#7
ObianujuNkiruka Okoroafor, Paul Chekwube Eze, Wilfred Sunday Ezema, Chika Nwosu, Christian Okorie-Kanu, P C Animoke, Boniface Anene, John Osita Arinze Okoye
The aim of this project is to study the clinical signs and lesion of velogenic Newcastle disease (vND) in commercial turkeys, and also to find out if La Sota vaccination offered protection against these signs and lesions. The cockerels were included as positive controls. One hundred and twenty turkey poults and cockerels were divided into eight groups as follows: unvaccinated unchallenged turkeys (UUT), unvaccinated challenged turkeys (UCT), vaccinated unchallenged turkeys (VUT), vaccinated challenged turkeys (VCT), and along the same lines, the cockerel groups were UUC, UCC, VUC and vaccinated challenged cockerels (VCC)...
February 2018: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/28754161/a-cross-sectional-study-of-maternal-near-miss-and-mortality-at-a-rural-tertiary-centre-in-southern-nigeria
#8
Ikechukwu Innocent Mbachu, Chukwuemeka Ezeama, Kelechi Osuagwu, Osita Samuel Umeononihu, Chibuzor Obiannika, Nkeiru Ezeama
BACKGROUND: The study evaluated the pattern of severe maternal outcome, near miss indicators and associated patient and healthcare factors at a private referral hospital in rural Nigeria. METHODS: This was a cross sectional study conducted from September 2014 to August 2015 in Madonna University Teaching Hospital Elele, Rivers State, Nigeria. Pregnant and postpartum women were recruited for the study using Nigeria near miss network proforma which was adopted from the WHO near miss proforma...
July 28, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28723963/impact-of-thyroid-function-abnormalities-on-reproductive-hormones-during-menstrual-cycle-in-premenopausal-hiv-infected-females-at-nauth-nnewi-nigeria
#9
Nkiruka Rose Ukibe, Solomon Nwabueze Ukibe, Obiageli Fidelia Emelumadu, Chinedum Charles Onyenekwe, Joseph Eberendu Ahaneku, Anthony Osita Igwegbe, Ifeoma Nwamaka Monago, Amobi Linus Ilika
BACKGROUND: This was a prospective study designed to evaluate the impact of thyroid function abnormalities on reproductive hormones during menstrual cycle in HIV infected females at Nnamdi Azikiwe University Teaching Hospital Nnewi, South-East Nigeria. METHODS: The study randomly recruited 35 Symptomatic HIV infected females and 35 Symptomatic HIV infected females on antiretroviral therapy (HAART) for not less than six weeks from an HIV clinic and 40 apparently heathy control females among the hospital staff of NAUTH Nnewi...
2017: PloS One
https://www.readbyqxmd.com/read/28515184/trends-and-population-attributable-risk-estimates-for-predictors-of-early-neonatal-mortality-in-nigeria-2003-2013-a-cross-sectional-analysis
#10
Osita Kingsley Ezeh
OBJECTIVES: To assess trends in early neonatal mortality (ENM) and population-attributable risk (PAR) estimates for predictors of ENM in Nigeria. DESIGN, SETTING AND PARTICIPANTS: A cross-sectional data on 63 844 singleton live births within the preceding 5 years from the 2003, 2008 and 2013 Nigeria Demographic and Health Surveys were used. Adjusted PARs were used to estimate the number of early neonatal deaths attributable to each predictor in the final multivariable Cox regression model...
May 17, 2017: BMJ Open
https://www.readbyqxmd.com/read/28395387/novel-techniques-and-approaches-to-minimally-invasive-thoracic-surgery
#11
Osita Onugha, Rasheed Ivey, Robert McKenna
Approximately two decades ago, thoracic surgery witnessed the leap from thoracotomy to the first video-assisted thoracic surgery (VATS) lobectomy. Minimally invasive lobectomy and hilar lymphadenectomy is now widely established as a safe and oncological sound technique that is the standard of care for early-stage lung cancer. The move toward less invasive surgery has no doubt driven the innovation of sophisticated instruments and technology to cope with the demanding need of working through a restricted incision...
July 25, 2017: Surgical Technology International
https://www.readbyqxmd.com/read/27974378/architecture-of-the-yeast-elongator-complex
#12
Maria I Dauden, Jan Kosinski, Olga Kolaj-Robin, Ambroise Desfosses, Alessandro Ori, Celine Faux, Niklas A Hoffmann, Osita F Onuma, Karin D Breunig, Martin Beck, Carsten Sachse, Bertrand Séraphin, Sebastian Glatt, Christoph W Müller
The highly conserved eukaryotic Elongator complex performs specific chemical modifications on wobble base uridines of tRNAs, which are essential for proteome stability and homeostasis. The complex is formed by six individual subunits (Elp1-6) that are all equally important for its tRNA modification activity. However, its overall architecture and the detailed reaction mechanism remain elusive. Here, we report the structures of the fully assembled yeast Elongator and the Elp123 sub-complex solved by an integrative structure determination approach showing that two copies of the Elp1, Elp2, and Elp3 subunits form a two-lobed scaffold, which binds Elp456 asymmetrically...
February 2017: EMBO Reports
https://www.readbyqxmd.com/read/27916655/allopurinol-as-a-therapeutic-option-in-cardiovascular-disease
#13
REVIEW
Osita N Okafor, K Farrington, Diana A Gorog
Epidemiological studies indicate that hyperuricaemia is an independent risk factor for cardiovascular disease. Alongside uric acid formation, increased xanthine oxidase activity also results in the formation of oxidative free radicals and superoxide particles. Oxidative stress significantly contributes to the development of cardiovascular disease, including endothelial cell dysfunction, atherosclerosis, vascular calcification and impaired myocardial energetics. Allopurinol, a competitive xanthine oxidase inhibitor, in addition to reducing serum uric acid levels, can act as a free radical scavenger...
April 2017: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/27780769/effect-of-backpack-strap-patterns-on-gait-parameters-in-young-adults-at-self-selected-normal-and-fast-walking-speeds
#14
Ukachukwu Okoroafor Abaraogu, Wisdom Onyedikachi Ugwa, Osita Nnodim, Elochukwu Fortune Ezenwankwo
BACKGROUND: The effects of backpack load on young adults' gait parameters have received little attention. We previously reported that with a backpack load within 15% body weight, young adults maintain their gait parameters at the expense of increased exertion during a 6-minute walk at self-selected normal walking speed. However, the effect of backpack strap pattern on gait parameters during faster walking or longer stride length has not been evaluated. OBJECTIVE: To determine the effect of different backpack strap patterns on gait parameters during a 12-minute walk test in young adults at self-selected normal and fast walking speeds...
October 22, 2016: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/27645826/atrophy-of-the-lymphoid-organs-and-suppression-of-antibody-response-caused-by-velogenic-newcastle-disease-virus-infection-in-chickens
#15
RANDOMIZED CONTROLLED TRIAL
Wilfred Sunday Ezema, Didacus Chukwuemeka Eze, Shodeinde Vincent Olu Shoyinka, John Osita Arinze Okoye
This project was undertaken to study the immunosuppressive capabilities of velogenic viscerotropic pathotype of Newcastle disease virus (VVNDV) infection in cockerels. Two hundred six-week-old cockerels were divided into four groups. Groups B/VUC and C/VC were vaccinated with LaSota in drinking water at 6 weeks of age. Groups C/VC and D/UC were challenged with VVNDV at 8 weeks of age. Three days post challenge (PC), the cockerels in group D/UC came down with clinical signs which included depression and greenish diarrhoea...
December 2016: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/27535390/surgical-treatment-of-lung-cancer
#16
REVIEW
Osita I Onugha, Jay M Lee
In this chapter, we discuss the preoperative evaluation that is necessary prior to surgical resection, stage-specific surgical management of lung cancer, and the procedural steps as well as the indications to a variety of surgical approaches to lung resection.
2016: Cancer Treatment and Research
https://www.readbyqxmd.com/read/27455459/structural-basis-for-trna-modification-by-elp3-from-dehalococcoides-mccartyi
#17
Sebastian Glatt, Rene Zabel, Olga Kolaj-Robin, Osita F Onuma, Florence Baudin, Andrea Graziadei, Valerio Taverniti, Ting-Yu Lin, Frauke Baymann, Bertrand Seraphin, Karin D Breunig, Christoph W Müller
During translation elongation, decoding is based on the recognition of codons by corresponding tRNA anticodon triplets. Molecular mechanisms that regulate global protein synthesis via specific base modifications in tRNA anticodons are receiving increasing attention. The conserved eukaryotic Elongator complex specifically modifies uridines located in the wobble base position of tRNAs. Mutations in Elongator subunits are associated with certain neurodegenerative diseases and cancer. Here we present the crystal structure of D...
September 2016: Nature Structural & Molecular Biology
https://www.readbyqxmd.com/read/27094212/relative-effects-of-different-non-vitamin-k-antagonist-oral-anticoagulants-on-global-thrombotic-status-in-atrial-fibrillation
#18
Mohamed Farag, Maria Niespialowska-Steuden, Osita Okafor, Benjamin Artman, Manivannan Srinivasan, Arif Khan, Keith Sullivan, David Wellsted, Diana A Gorog
Non-vitamin K antagonist oral anticoagulants (NOACs) reduce the risk of thromboembolism in patients with atrial fibrillation (AF). There has been no head-to-head comparison of the effect of these agents on ex vivo thrombotic and thrombolytic status. Enhanced platelet reactivity and impaired endogenous thrombolysis are risk factors for recurrent thrombotic events. We aimed to assess the comparative effect of NOACs and warfarin using an ex vivo test of thrombosis and thrombolysis. Eighty patients with newly diagnosed non-valvular AF were tested before, and after being established on apixaban (n = 20), dabigatran (n = 20), rivaroxaban (n = 20), or warfarin (n = 20)...
November 2016: Platelets
https://www.readbyqxmd.com/read/26511428/vitamin-a-dietary-supplementation-reduces-the-mortality-of-velogenic-newcastle-disease-significantly-in-cockerels
#19
Godwin Chinedu Okpe, Wilfred Sunday Ezema, Shodeinde Vincent Olumuyiwa Shoyinka, John Osita Arinze Okoye
This project was undertaken to find ways of reducing mortalities and economic losses due to velogenic Newcastle disease (VND) in areas where the disease is enzootic. Four groups of cockerels of 44 birds each were used for this experiment. The birds in groups 1 and 2 received no dietary vitamin A supplementation, whereas groups 3 and 4 received 300 iu and 600 iu of vitamin A per kilogram of commercial feed, respectively, from 1 week of age till the end of the experiment. At 6 weeks of age, the birds in groups 2, 3 and 4 were inoculated intraocularly with a VND virus (duck/Nigeria/Plateau/Kuru/113/1991)...
October 2015: International Journal of Experimental Pathology
https://www.readbyqxmd.com/read/26459010/the-evaluation-of-accuracy-of-serial-rapid-hiv-test-algorithm-in-the-diagnosis-of-hiv-antibodies-among-pregnant-women-in-south-east-nigeria
#20
Ikechukwu Innocent Mbachu, Gerald Udigwe, Ikechebelu Joseph, Okonkwo John, Umeononihu Osita Samuel, Ugboaja Joseph, Mbachu Chioma Ngozi
BACKGROUND: Accurate HIV testing in pregnancy is critical to the prevention of mother to child transmission of HIV infection and linkages to other preventive strategies. AIMS AND OBJECTIVES: This study determined the sensitivity, specificity negative and positive predictive value of serial rapid testing of HIV among pregnant women in Nnewi, south east Nigeria. METHODOLOGY: This was a comparative descriptive study conducted over a 4-month period...
2015: BMC Research Notes
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