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osteoporotic fractures

J Hack, A Krüger, A Masaeli, R Aigner, S Ruchholtz, L Oberkircher
INTRODUCTION: Cement-augmentation is a well-established way to improve the stability of sacroiliac screw fixation in osteoporosis-associated fragility fractures of the posterior pelvic ring. However, to date little is known about the influence of different techniques of cement augmentation on construct stability. The aim of this study was to evaluate the primary stability of cement-augmented sacroiliac screw fixation with cannulated versus perforated screws under cyclic loading. MATERIALS AND METHODS: A total of eight fresh-frozen human cadaveric hemipelvis specimens with osteoporosis were used...
June 9, 2018: Injury
Jingchuan Sun, Qingjie Kong, Yong Yang, Jiangang Shi, Yang Hou, Ximing Xu, Yuan Wang, Haisong Yang, Yongfei Guo, Guodong Shi, Yingjie Wang, Peng Zhang
PURPOSE: This study is to determine whether implantation of a newly designed non-fusion intracorporeal enhancement (NICE) system is an effective and a safe way for the treatment of osteoporotic vertebral compression fracture (OVCF). METHODS: 13 OVCF patients (10 women, 3 men, mean age 69, T11 to L4) were included. From June 2014 to June 2016 all of them were treated with the NICE system. The clinical and radiological results were both evaluated preoperatively, postoperatively, 24 months follow-up based on the visual analog scale (VAS) and the Oswestry Disability Index (ODI), X-ray, MRI and CT (Height of fractured body and kyphosis Cobb angle)...
June 15, 2018: World Neurosurgery
Anne-Birgitte Blavnsfeldt, Annette de Thurah, Malissa Dawn Thomsen, Simon Tarp, Bente Langdahl, Ellen-Margrethe Hauge
PURPOSE: The role of glucocorticoids in the treatment of rheumatoid arthritis (RA) is widely debated. Impairment of bone formation may be counter-balanced by reduced systemic inflammation. This review aims to assess the effect of prednisolone/prednisone on bone mineral density (BMD) in patients with RA analyzed in randomized, controlled trials. METHODS: We performed a systematic literature search and identified randomized, double-blinded placebo-controlled studies including patients with RA and using prednisolone or prednisone as the intervention...
June 15, 2018: Bone
L Pietrogrande, E Raimondo
Abaloparatide is a synthetic 34-amino acid peptide analogue of the 1-34 portion of the human parathyroid hormone-related protein (PTHrP). It has been approved in the U.S. for the treatment of postmenopausal women with osteoporosis at a high risk for fracture. Abaloparatide is an anabolic agent and it seems to have a potent anabolic activity with reduced effects on bone resorption. It reduces the risk of vertebral and nonvertebral fractures, major osteoporotic fractures and clinical fractures, with a significant improvement in bone mineral density at femoral neck, total hip and lumbar spine...
May 2018: Drugs of Today
Lali Tsiklauri, Janina Werner, Marian Kampschulte, Klaus W Frommer, Lucija Berninger, Martina Irrgang, Kristina Glenske, Dirk Hose, Thaqif El Khassawna, Jörn Pons-Kühnemann, Stefan Rehart, Sabine Wenisch, Ulf Müller-Ladner, Elena Neumann
OBJECTIVES: Age-related bone loss is associated with bone marrow adiposity. Adipokines (e.g. visfatin, resistin, leptin) are adipocyte-derived factors with immunomodulatory properties and might influence differentiation of bone marrow-derived mesenchymal stem cells (MSC) in osteoarthritis (OA) and osteoporosis. Thus, the presence of adipokines and MMPs in bone marrow and their effects on MSC differentiation were analyzed. METHODS: MSC and RNA were isolated from femoral heads after hip replacement surgery of OA or osteoporotic femoral neck fracture (FF) patients...
June 13, 2018: Osteoarthritis and Cartilage
Pushpa Suriyaarachchi, Fernando Gomez, Carmen L Curcio, Derek Boersma, Lavanya Murthy, Vivian Grill, Gustavo Duque
OBJECTIVES: The combination of osteopenia/osteoporosis and sarcopenia (osteosarcopenia) defines a diagnostic subset of individuals at higher risk of falls, fractures and institutionalization. In this study we aimed to assess the potential role of high serum levels of parathyroid hormone (PTH) in osteosarcopenia. We hypothesized that a high PTH level is one of the major determinants of this syndrome. STUDY DESIGN: Cross-sectional study in 400 subjects (mean age = 79, 65% women) assessed between 2009 and 2014 at the Falls and Fractures Clinic, Nepean Hospital (Penrith, Australia)...
July 2018: Maturitas
L Xi, P De Falco, E Barbieri, A Karunaratne, L Bentley, C T Esapa, N J Terrill, S D M Brown, R D Cox, G R Davis, N M Pugno, R V Thakker, H S Gupta
Glucocorticoid-induced osteoporosis (GIOP) is a major secondary form of osteoporosis, with the fracture risk significantly elevated - at similar levels of bone mineral density - in patients taking glucocorticoids compared with non-users. The adverse bone structural changes at multiple hierarchical levels in GIOP, and their mechanistic consequences leading to reduced load-bearing capacity, are not clearly understood. Here we combine experimental X-ray nanoscale mechanical imaging with analytical modelling of the bone matrix mechanics to determine mechanisms causing bone material quality deterioration during development of GIOP...
June 11, 2018: Acta Biomaterialia
Sina Pourtaheri, William Luo, Christina Cui, Steven Garfin
STUDY DESIGN: This is a systematic review and meta-analysis. OBJECTIVE: This study's goal was to (i) assess the clinical outcomes with and without vertebral augmentation (VA) for osteoporotic vertebral compression fractures (VCFs) with versus without correlating signs and symptoms; and (ii) acute (symptoms <3 mo duration) and subacute VCFs (3-6 mo duration) versus chronic VCFs (>6 mo). SUMMARY OF BACKGROUND DATA: Previously, a randomized controlled trial in the New England Journal of Medicine concluded that vertebroplasty for osteoporotic VCFs provided no clinical benefit over sham surgery...
June 12, 2018: Clinical Spine Surgery
Jaewon Yang, Namki Hong, Jee-Seon Shim, Yumie Rhee, Hyeon Chang Kim
Background: Type 2 diabetes mellitus is associated with an increased risk of osteoporotic fracture despite relatively preserved bone mineral density (BMD). Although this paradox might be attributed to the influence of insulin resistance (IR) on bone structure and material properties, the association of IR with femur bone geometry and strength indices remains unclear. Methods: Using data from the Cardiovascular and Metabolic Disease Etiology Research Center cohort study, we conducted a cross-sectional analysis among nondiabetic postmenopausal women...
May 2018: Journal of Bone Metabolism
Won Seok Jo, Eun Hee Cho, Beon Jung Kang, Gi Du Kwon, Yong-Chan Ha, Sunmee Jang, Ha Young Kim
Background: The purpose of this study was to determine the impact of an educational intervention that includes information sharing about absolute fracture risk on the knowledge of osteoporosis and modifiable risk factors among Korean patients with osteoporosis. Methods: Adults aged >50 years who visited the outpatient clinic for osteoporosis were recruited. Subjects with trauma-related fractures or pathological fractures were excluded. The anthropometric data and clinical risk factors for fracture were collected at baseline...
May 2018: Journal of Bone Metabolism
Mohammed-Salleh M Ardawi, Abdulrahim A Rouzi, Nawal S Al-Senani, Mohammed H Qari, Ayman Z Elsamanoudy, Shaker A Mousa
Background: Higher sphingosine 1-phosphate (S1P) plasma levels are associated with decreased bone mineral density (BMD), and increased risk of prevalent vertebral fracture. So, we hypothesized that postmenopausal women with increased baseline plasma S1P levels have a greater risk for future incident fracture (osteoporosis-related fractures [ORFs]). Methods: This study was conducted in a prospective longitudinal cohort of 707 women recruited in 2004 and followed up annually for a mean period of 5...
May 2018: Journal of Bone Metabolism
Byung-Ho Yoon, Woojin Yu
Bone turnover markers (BTMs) are released during bone remodeling and are thought to reflect the metabolic activity of bone at the cellular level. This review examines BTM as a biological response marker for monitoring future fracture prediction and fracture healing processes. Substantial evidence has been of high value to investigate the use of BTM in fracture risk prediction; nevertheless, the conclusions of some studies are inconsistent due to their large variability. BTM is promising for fracture risk prediction for adopting international reference standards or providing absolute risks, such as 10-year fracture probabilities...
May 2018: Journal of Bone Metabolism
Junkichi Kanda, Nobuo Izumo, Megumi Furukawa, Taketoshi Shimakura, Noriaki Yamamoto, Hideaki E Takahashi, Toshinari Asakura, Hiroyuki Wakabayashi
Immunosuppressive therapy is considered as one of the factors inducing to the onset of osteoporosis after organ transplantation. Chronic immunosuppressive therapy after transplantation is required for organ transplant patients, and it is important to prevent the occurrence of osteoporotic fractures to maintain the quality of life in patients. In this study, we examined the effects of cyclosporine and tacrolimus on bone metabolism in rats. Five-week-old male Wistar rats were treated orally with 15 mg/kg cyclosporine or 1...
2018: Biomedical Research
Samuel Jesús Ramos-Infante, Amadeo Ten-Esteve, Angel Alberich-Bayarri, María Angeles Pérez
This paper proposes a discrete particle model based on the random-walk theory for simulating cement infiltration within open-cell structures to prevent osteoporotic proximal femur fractures. Model parameters consider the cement viscosity (high and low) and the desired direction of injection (vertical and diagonal). In vitro and in silico characterizations of augmented open-cell structures validated the computational model and quantified the improved mechanical properties (Young's modulus) of the augmented specimens...
2018: PloS One
Peggy M Cawthon, Eric S Orwoll, Katherine E Peters, Kristine E Ensrud, Jane A Cauley, Deborah M Kado, Marcia L Stefanick, James M Shikany, Elsa S Strotmeyer, Nancy W Glynn, Paolo Caserotti, Mahalakshmi Shankaran, Marc Hellerstein, Steven R Cummings, William J Evans
Background: Direct assessment of skeletal muscle mass in older adults is clinically challenging. Relationships between lean mass and late-life outcomes have been inconsistent. The D3-creatine dilution method provides a direct assessment of muscle mass. Methods: Muscle mass was assessed by D3-creatine (D3Cr) dilution in 1,382 men (mean age, 84.2 yrs). Participants completed the Short Physical Performance Battery (SPPB); usual walking speed (6 meters); and DXA lean mass...
June 12, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
Rao Xu, Jiangying Ru, Feng Ji, Jie Liu, Yong Ji, Zhiquan Wu, Dai Shi
The aim of the present study was to compare the efficacy and complications of two fixation techniques, namely dynamic hip screw (DHS) and proximal femoral nail antirotation (PFNA), in the treatment of osteoporotic femoral intertrochanteric fracture in elderly patients, and to detect changes in transforming growth factor β2 (TGF-β2) expression in the two groups. A total of 100 elderly patients with femoral intertrochanteric fracture were randomly divided into two groups that were treated with either DHS or PFNA...
July 2018: Experimental and Therapeutic Medicine
Anna Paschall, Ann H Ross
OBJECTIVES: Sex and age trends in bone mineral density (BMD) play an important role in the estimation of age-at-death (AAD) of unidentified human remains. Current methodologies lack the ability to precisely estimate age in older individuals. In this study, BMD of the cranium and femur measured by DXA were examined to establish their applicability for age estimation in older adults. BMD as measured by DXA, is most commonly used clinically for prediction of osteoporotic fracture risk. We hypothesized that weight-bearing and non-weight-bearing bones, the femur and cranium, respectively, would provide valuable insights for aging...
July 2018: Science & Justice: Journal of the Forensic Science Society
Yong-Bo Li, Xi Zheng, Rui Wang, Han Wu, Shuo Han, Zhi-Yang Deng, Dong Sun
OBJECTIVE: This study aimed to evaluate the difference and consistency between single-photon emission computed tomography-computed tomography (SPECT-CT) and MRI in diagnosing osteoporotic vertebral compression fractures (OVCFs) and identifying active lesions. PATIENTS AND METHODS: All 46 patients underwent SPECT-CT and MRI examinations. The pain vertebral body and pain sites were determined using both MRI and SPECT-CT during percutaneous kyphoplasty (PKP). The differences before and after treatment were assessed using visual analog scale scores and evaluated using a paired t-test...
July 2018: Nuclear Medicine Communications
Viral N Shah, Mengdi Wu, Nicole Foster, Ruban Dhaliwal, Mona Al Mukaddam
We evaluated fall frequency and factors affecting falls among middle-aged and older adults with type 1 diabetes (T1D) from T1D Exchange Registry. Twenty-nine percent of T1D participants reported falls within the past 12 months. Severe hypoglycemia, diabetic peripheral neuropathy, and depression were associated with falls in adults with T1D. PURPOSE: Fall is an important risk factor for osteoporotic fracture; we evaluated fall frequency and factors affecting falls among middle-aged and older adults with type 1 diabetes (T1D)...
June 12, 2018: Archives of Osteoporosis
Li Cheng, Shengyuan Zhou, Yin Zhao, Yanqing Sun, Zheng Xu, Bo Yuan, Xiongsheng Chen
Osteoporosis is a common disease associated with age and menopausal status. Postmenopausal osteoporosis is the most common type of primary osteoporosis and is accompanied by increased risk of osteoporotic fracture. Natural and herbal compounds have long been used to prevent and treat many human diseases. Here, we demonstrated that tanshinone IIA prevented ovariectomy-induced bone loss in an in vivo mouse model that closely mimics osteoporosis. In addition, we found that tanshinone IIA inhibited the receptor activator of nuclear factor NF-κB ligand (RANKL)-induced osteoclast differentiation and osteoclastogenesis in vitro ...
2018: American Journal of Translational Research
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