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osteoporotic fractures

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https://www.readbyqxmd.com/read/29684237/frailty-phenotype-and-healthcare-costs-and-utilization-in-older-women
#1
Kristine E Ensrud, Allyson M Kats, John T Schousboe, Brent C Taylor, Peggy M Cawthon, Teresa A Hillier, Kristine Yaffe, Steve R Cummings, Jane A Cauley, Lisa Langsetmo
OBJECTIVES: To determine the association of the frailty phenotype with subsequent healthcare costs and utilization. DESIGN: Prospective cohort study (Study of Osteoporotic Fractures (SOF)). SETTING: Four U.S. sites. PARTICIPANTS: Community-dwelling women (mean age 80.2) participating in SOF Year 10 (Y10) examination linked with their Medicare claims data (N=2,150). MEASUREMENTS: At Y10, frailty phenotype defined using criteria similar to those used in the Cardiovascular Health Study frailty phenotype and categorized as robust, intermediate stage, or frail...
April 23, 2018: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29683811/is-cement-augmentation-a-viable-treatment-option-for-an-osteoporotic-compression-fracture
#2
Saad B Chaudhary, Jason W Savage
No abstract text is available yet for this article.
April 20, 2018: Clinical Spine Surgery
https://www.readbyqxmd.com/read/29681582/subchondral-insufficiency-fracture-of-the-femoral-head-in-a-pregnant-woman-with-pre-existing-anorexia-nervosa
#3
Kyoko Kasahara, Tomohiro Mimura, Suzuko Moritani, Taku Kawasaki, Shinji Imai, Shunichiro Tsuji, Fuminori Kimura, Takashi Murakami
Subchondral insufficiency fracture (SIF) is a fragility fracture secondary to osteoporosis that leads to collapse of the femoral head with no evidence of osteonecrosis. SIF of the femoral head has been reported in adults of varying ages and both sexes, but it has never been reported to occur in pregnant women. Herein, we describe a 40-year-old primiparous patient with pre-existing anorexia nervosa who developed SIF of the femoral head in the third trimester. At 29 weeks of gestation, the patient complained of sudden pain on walking in both hips...
2018: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/29681437/comparison-of-locking-versus-nonlocking-plates-for-distal-fibula-fractures
#4
Shirley A Lyle, Catherine Malik, Michael J Oddy
Locking plates might offer a biomechanical fixation advantage for distal fibula fractures with comminution or osteoporotic bone. In January 2011, our unit introduced a bone-specific locking plate for the distal fibula. The aim of the present study was to compare it against more conventional plating system implants for lateral malleolar fixation in terms of outcomes, crude costs, and complications. We retrospectively reviewed a consecutive cohort of patients with closed ankle fractures who presented within a 24-month period...
April 19, 2018: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/29680263/healing-of-fractures-in-osteoporotic-bones-in-mice-treated-with-bisphosphonates-a-transcriptome-analysis
#5
Michel Hauser, Mark Siegrist, Irene Keller, Willy Hofstetter
Bisphosphonates (BP) are inhibitors of bone resorption and are used to treat postmenopausal osteoporosis. Long-term treatment with BP attenuates bone remodeling, possibly leading to detrimental consequences for the bones' ability to repair defects. To test this hypothesis, an animal model was established. Twelve week old mice were ovariectomized (OVX). Following confirmation of bone loss 8 weeks after OVX, the animals were treated with Alendronate (ALN) until sacrifice. After 5 weeks of ALN injections, the femoral bones were osteotomized and the osteotomies were either rigidly or non-rigidly stabilized...
April 20, 2018: Bone
https://www.readbyqxmd.com/read/29680168/the-degeneration-of-adjacent-intervertebral-discs-negatively-influence-union-rate-of-osteoporotic-vertebral-fracture-a-multicenter-cohort-study
#6
Mohammad Suhrab Rahmani, Shinji Takahashi, Masatoshi Hoshino, Kazushi Takayama, Ryuichi Sasaoka, Tadao Tsujio, Hiroyuki Yasuda, Fumiaki Kanematsu, Hiroshi Kono, Hiromitsu Toyoda, Hiroaki Nakamura
BACKGROUND: With the increasing aging population in developed countries, there has been an associated increased prevalence of osteoporotic vertebral fracture (OVF). Many previous reports have attempted to predict the risk of delayed union associated with OVF. However, the role of endplate failure and the degeneration of adjacent intervertebral discs, and their association with delayed union has received little attention. The aim of this study was to evaluate the endplate fracture and disc degeneration rank as risk factors for delayed union...
April 18, 2018: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/29679717/stat-3-regulation-of-cxcr4-is-necessary-for-the-prenylflavonoid-icaritin-to-enhance-mesenchymal-stem-cell-proliferation-migration-and-osteogenic-differentiation
#7
R Z L Lim, L Li, E L Yong, N Chew
Mesenchymal stem cell (MSC) dysfunction has been implicated in the pathogenesis of osteoporosis. MSCs derived from osteoporotic subjects demonstrate significant impairment in proliferation, adhesion and chemotaxis, and osteogenic differentiation, leading to reduced functional bone-forming osteoblasts and ultimately nett bone loss and osteoporosis. Epimedium herbs and its active compound Icaritin (ICT) have been used in Chinese ethnopharmacology for the treatment of metabolic bone diseases. Using an in-vitro cell culture model, we investigated the benefits of ICT treatment in enhancing MSC proliferation, migration and osteogenic differentiation, and provide novel data to describe its mechanism of action...
April 18, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29678706/mid-term-clinical-and-radiological-outcomes-after-kyphoplasty-in-the-treatment-of-thoracolumbar-traumatic-vertebral-compression-fractures
#8
Michael Grelat, Rachid Madkouri, Pierre-Olivier Comby, Elie Fahed, Brivael Lemogne, Pierre Thouant
OBJECTIVE: The management of thoracolumbar post-traumatic compression fractures widely varies among centers, and there is no real consensus. The objective of our retrospective study was to detect the progression of vertebral kyphosis in non-osteoporotic patients treated by balloon kyphoplasty (KPB) who presented recent compression fractures of the thoracolumbar region. MATERIALS AND METHODS: From 2007 to 2011, we focused in this retrospective study on the vertebral and regional kyphosis evolution in 77 patients treated by KPB for compression vertebral fractures (Magerl A)...
April 17, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29677554/glass-polyalkenoate-cement-an-alternative-material-for-kyphoplasty-in-osteoporotic-vertebral-compression-fractures-an-ex-vivo-study
#9
Tim Leschinger, Karsten Engel, Gert Peter Brüggemann, Viktoria Dederer, Wolfram Friedrich Neiss, Max Joseph Scheyerer, Lars Peter Müller, Kilian Wegmann
Adjacent vertebral body fracture is described as a risk after vertebroplasty and kyphoplasty. It may be true that this phenomenon is caused precisely because of the frequently used polymethylmethacrylate cement (PMMA), which shows a higher level of stiffness than bone material and may ultimately lead to shifting stress levels within the entire spine. The goal of the present study was to evaluate and compare the pressure distribution in the endplate of human vertebrae after kyphoplasty with PMMA and aluminum-free glass-polyalkenoate cement (gpc)...
March 21, 2018: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29677309/vitamin-d-calcium-or-combined-supplementation-for-the-primary-prevention-of-fractures-in-community-dwelling-adults-us-preventive-services-task-force-recommendation-statement
#10
David C Grossman, Susan J Curry, Douglas K Owens, Michael J Barry, Aaron B Caughey, Karina W Davidson, Chyke A Doubeni, John W Epling, Alex R Kemper, Alex H Krist, Martha Kubik, Seth Landefeld, Carol M Mangione, Michael Silverstein, Melissa A Simon, Chien-Wen Tseng
Importance: Because of the aging population, osteoporotic fractures are an increasingly important cause of morbidity and mortality in the United States. Approximately 2 million osteoporotic fractures occurred in the United States in 2005, and annual incidence is projected to increase to more than 3 million fractures by 2025. Within 1 year of experiencing a hip fracture, many patients are unable to walk independently, more than half require assistance with activities of daily living, and 20% to 30% of patients will die...
April 17, 2018: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29677308/vitamin-d-calcium-or-combined-supplementation-for-the-primary-prevention-of-fractures-in-community-dwelling-adults-evidence-report-and-systematic-review-for-the-us-preventive-services-task-force
#11
Leila C Kahwati, Rachel Palmieri Weber, Huiling Pan, Margaret Gourlay, Erin LeBlanc, Manny Coker-Schwimmer, Meera Viswanathan
Importance: Osteoporotic fractures result in significant morbidity and mortality. Objective: To update the evidence for benefits and harms of vitamin D, calcium, or combined supplementation for the primary prevention of fractures in community-dwelling adults to inform the US Preventive Services Task Force. Data Sources: PubMed, EMBASE, Cochrane Library, and trial registries through March 21, 2017; references; and experts. Surveillance continued through February 28, 2018...
April 17, 2018: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29675770/sports-participation-and-fracture-in-older-australian-men
#12
Kara L Holloway-Kew, David J Moloney, Gosia Bucki-Smith, Natalie K Hyde, Sharon L Brennan-Olsen, Elizabeth N Timney, Amelia G Dobbins, Julie A Pasco
Older men who participated in a sporting activity were less likely to sustain any fracture or major osteoporotic fracture over a 6-year follow-up period. PURPOSE: Regular weight-bearing physical activity can reduce fracture risk through an increase in bone strength, as well as reducing falls risk by improving muscle strength and balance. In this study, we aimed to determine whether a specific type of physical activity, sports participation, reduces fracture risk in older Australian men...
April 19, 2018: Archives of Osteoporosis
https://www.readbyqxmd.com/read/29675674/osteoporotic-thoracolumbar-compression-fractures-long-term-retrospective-comparison-between-vertebroplasty-and-conservative-treatment
#13
Konstantinos Martikos, Tiziana Greggi, Cesare Faldini, Francesco Vommaro, Antonio Scarale
PURPOSE: To compare long term clinical and radiographic outcomes in osteoporotic vertebral compression fractures of the thoracolumbar spine treated with conservative treatment and percutaneous vertebroplasty. METHODS: The retrospective study with inclusion criteria focused on osteoporotic fractures of the thoracolumbar junction (T10-L2). Clinical outcomes were evaluated by using the VAS, Oswestry and SF36 questionnaires. Radiographic outcomes were evaluated by comparing the following sagittal parameters: body angle, sagittal index of fractured vertebral body and adjacent vertebral segments kyphosis...
April 19, 2018: European Spine Journal
https://www.readbyqxmd.com/read/29673097/effects-of-implant-delivered-insulin-on-bone-formation-in-osteoporotic-rats
#14
B Ö Malekzadeh, M C Erlandsson, P Tengvall, A Palmquist, M Ransjo, M I Bokarewa, A Westerlund
Osteoporosis is a major cause of age-related fractures. Healing complications in osteoporotic patients are often associated with increased mortality and morbidity. Stimulation of the implant-adjacent bone could be beneficial in terms of the surgical outcome. Over the past decade, numerous investigations have implicated insulin in normal bone growth, and recent studies have described the advantages of administering insulin locally to increase bone formation. Therefore, we hypothesized that insulin-coated titanium implants would increase bone formation in osteoporotic animals...
April 19, 2018: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29667007/failure-in-diagnosis-and-under-treatment-of-osteoporosis-in-elderly-patients-with-fragility-fractures
#15
Sofia Bougioukli, Panagoula Κollia, Theodora Koromila, Sokratis Varitimidis, Michael Hantes, Theofilos Karachalios, Κonstantinos Ν Malizos, Zoe H Dailiana
We evaluated whether osteoporosis is adequately managed and treated in patients suffering from fragility fractures. Factors that influenced osteoporosis diagnosis and treatment rates were also assessed. To this end, patients with the principal diagnosis of low-energy hip, vertebral, or distal radius fractures were recruited for the study. Collected data included risk factors for osteoporosis, history of previous fractures, known history of osteoporosis, and osteoporosis treatment at the time of admission. The patients' prefracture risk profile was also assessed to determine whether osteoporosis could have been identified prior to the index fracture...
April 17, 2018: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/29664815/long-term-posttraumatic-survival-of-spinal-fracture-patients-in-northern-finland
#16
Ville Niemi-Nikkola, Nelli Saijets, Henrikka Ylipoussu, Pietari Kinnunen, Juha Pesälä, Pirkka Mäkelä, Markku Alen, Mauri Kallinen, Aki Vainionpää
STUDY DESIGN: A retrospective epidemiological study. OBJECTIVE: To reveal the long-term survival and causes of death after traumatic spinal fracture (TSF) and to determine the possible factors predicting death. SUMMARY OF BACKGROUND DATA: Increased mortality following osteoporotic spinal fracture has been represented in several studies. Earlier studies concerning mortality after TSF have focused on specific types of fractures, or else only the mortality of the acute phases has been documented...
April 16, 2018: Spine
https://www.readbyqxmd.com/read/29664526/-perioperative-care-of-older-patients-with-hip-fractures
#17
Francisco Bengoa, Marcela Carrasco, Pedro Pablo Amenábar, Daniel Schweitzer, Eduardo Botello, Ianiv Klaber
The number of osteoporotic fractures is increasing along with population aging. Most patients with these type of fractures are older than 65 years, with multiple chronic conditions and different degrees of disability. Hip fracture is the most relevant osteoporotic fracture due to its frequency, costs, severity and complications. Multidisciplinary management is of the utmost importance to obtain good therapeutic results. We herein review the management of this fracture. Orthogeriatric joint management should be incorporated in fragility fracture treatment...
November 2017: Revista Médica de Chile
https://www.readbyqxmd.com/read/29662781/the-effect-of-chinese-martial-arts-tai-chi-chuan-on-prevention-of-osteoporosis-a-systematic-review
#18
REVIEW
Tsz Ho Chow, Bo Yee Lee, Adrian Bing Fung Ang, Veronica Yi Ki Cheung, Michelle Man Ching Ho, Saori Takemura
Background/Objective: Tai Chi Chuan (TCC) is suggested to have beneficial effects on the musculoskeletal system. The aim of this systematic review is to evaluate the evidence of the effect of TCC on bone mineral density (BMD) and its potential for prevention of osteoporosis. Methods: A literature search was conducted using PubMed, Embase, and Cochrane databases from inception to January 2017. Randomized controlled studies, case-control trials, prospective cohort studies, and cross-sectional studies which evaluated the effect of TCC on BMD were selected without any subject or language restriction...
January 2018: Journal of Orthopaedic Translation
https://www.readbyqxmd.com/read/29662773/characteristics-of-bone-biochemical-indices-in-predicting-secondary-osteoporotic-fracture-after-intertrochanteric-fracture-in-elderly-women
#19
Shaofeng Yang, Yanan Liu, Qin Shi, Jun Zou, Huilin Yang
Background: This study aimed to explore the characteristics of bone biochemical indices, including bone mineral density (BMD), metabolic markers in elderly women with osteoporotic intertrochanteric fracture and their relevance in secondary fracture. Methods: The standard for follow-up from 58 elderly women was established to analyse the BMD in the injured hip, healthy hip, and the vertebra at 1 week and 12 months after fracture. The serum levels of total procollagen type N-terminal propeptide (tPINP) and the age-related type I cross linked C-telopeptide (β-CTX) were recorded and compared between those patients with and without secondary fractures within 12 months...
January 2018: Journal of Orthopaedic Translation
https://www.readbyqxmd.com/read/29662772/editorial-for-the-clinical-paper-therapeutic-effects-analysis-of-percutaneous-kyphoplasty-for-osteoporotic-vertebral-compression-fractures-a-multicentre-study-huilin-yang-et-al
#20
EDITORIAL
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