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osteoporotic fractures

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https://www.readbyqxmd.com/read/29220072/falls-predict-fractures-independently-of-frax-probability-a-meta-analysis-of-the-osteoporotic-fractures-in-men-mros-study
#1
Nicholas C Harvey, Anders Odén, Eric Orwoll, Jodi Lapidus, Timothy Kwok, Magnus K Karlsson, Björn E Rosengren, Östen Ljunggren, Cyrus Cooper, Eugene McCloskey, John A Kanis, Claes Ohlsson, Dan Mellström, Helena Johansson
Although prior falls are a well-established predictor of future fracture, there is currently limited evidence regarding the specific value of falls history in fracture risk assessment relative to that of other clinical risk factors and bone mineral density (BMD) measurement. We therefore investigated, across the three Osteoporotic Fractures in Men (MrOS) Study cohorts, whether past falls predicted future fracture independently of FRAX and whether these associations varied with age and follow-up time. Elderly men were recruited from MrOS Sweden, Hong Kong, and USA...
December 8, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29218502/lower-preoperative-hounsfield-unit-values-are-associated-with-intra-operative-fractures-in-cementless-bipolar-hemiarthroplasty
#2
Seung-Ju Kim, Hyun-Soo Park, Dong-Woo Lee, Jong Hun Kim
The use of Hounsfield units (HU) from CT scanning to assess regional BMD has been described. Therefore, we evaluated whether HU could be used to identify osteoporosis of the proximal part of the femur. The results showed that HU assessment is associated with the presence of intra-operative fracture during arthroplasty. INTRODUCTION: The aim with this study was to determine the association of preoperative Hounsfield unit (HU) in hip computed tomography (CT) with intra-operative osteoporotic fracture during cementless hemiarthroplasty...
December 7, 2017: Archives of Osteoporosis
https://www.readbyqxmd.com/read/29218381/effectiveness-of-a-two-step-population-based-osteoporosis-screening-program-using-frax-the-randomized-risk-stratified-osteoporosis-strategy-evaluation-rose-study
#3
K H Rubin, M J Rothmann, T Holmberg, M Høiberg, S Möller, R Barkmann, C C Glüer, A P Hermann, M Bech, J Gram, K Brixen
The Risk-stratified Osteoporosis Strategy Evaluation (ROSE) study investigated the effectiveness of a two-step screening program for osteoporosis in women. We found no overall reduction in fractures from systematic screening compared to the current case-finding strategy. The group of moderate- to high-risk women, who accepted the invitation to DXA, seemed to benefit from the program. INTRODUCTION: The purpose of the ROSE study was to investigate the effectiveness of a two-step population-based osteoporosis screening program using the Fracture Risk Assessment Tool (FRAX) derived from a self-administered questionnaire to select women for DXA scan...
December 7, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/29216500/strontium-and-bisphosphonate-coated-iron-foam-scaffolds-for-osteoporotic-fracture-defect-healing
#4
Seemun Ray, Ulrich Thormann, Marlen Eichelroth, Matthäus Budak, Christoph Biehl, Markus Rupp, Ursula Sommer, Thaqif El Khassawna, Francisca I Alagboso, Marian Kampschulte, Marcus Rohnke, Anja Henß, Klaus Peppler, Vanessa Linke, Peter Quadbeck, Axel Voigt, Florian Stenger, Daniel Karl, Reinhard Schnettler, Christian Heiss, Katrin S Lips, Volker Alt
The purpose of this work was to investigate new bone formation in macroporous iron foams coated with strontium (FeSr) or bisphosphonate (FeBiP) compared to plain iron foam (Fe) and empty defect in a critical size metaphyseal bone defect model in ovariectomized rats. 60 female rats were subjected to bilateral ovariectomy and multi-deficient diet for 3 months. A 4 mm wedge shaped metaphyseal osteotomy was created, fixed with a mini-plate and subsequently filled with Fe, FeSr, FeBiP or left empty. After 6 weeks, μCt analysis revealed a statistically significant increased bone formation at the implant interface in FeSr compared to FeBiP (p = 0...
December 1, 2017: Biomaterials
https://www.readbyqxmd.com/read/29216254/international-classification-of-diseases-icd-coded-obesity-predicts-risk-of-incident-osteoporotic-fracture
#5
Shuman Yang, Lisa M Lix, Lin Yan, Aynslie M Hinds, William D Leslie
International Classification of Diseases (ICD) codes have been used to ascertain individuals who are obese. There has been limited research about the predictive value of ICD-coded obesity for major chronic conditions at the population level. We tested the utility of ICD-coded obesity versus measured obesity for predicting incident major osteoporotic fracture (MOF), after adjusting for covariates (i.e., age and sex). In this historical cohort study (2001-2015), we selected 61,854 individuals aged 50 years and older from the Manitoba Bone Mineral Density Database, Canada...
2017: PloS One
https://www.readbyqxmd.com/read/29211449/novel-reduced-graphene-oxide-zinc-silicate-calcium-silicate-electroconductive-biocomposite-for-stimulating-osteoporotic-bone-regeneration
#6
Kun Xiong, Tingting Wu, Qingbo Fan, Lin Chen, Minhao Yan
In the absence of external assistance autogenous healing of bone fracture is difficult due to an impaired regeneration ability under osteoporosis pathological condition. In this study, a reduced graphene oxide-zinc silicate-calcium silicate (RGO-ZS-CS) conductive biocomposite with an optimal surface electroconductivity of 5625 S/m was prepared by a two-step spin-coating method. The presence of lamellar apatite nanocrystals on the surfaces of the biocomposite, suggest that it has good in vitro biomineralization compatability...
December 6, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29209855/osteoporotic-hip-fractures-in-black-south-africans-a-regional-study
#7
F Paruk, G Matthews, B Cassim
Osteoporotic hip fractures are thought to be rare in Blacks however, this study from South Africa shows a significant increase in the number of hip fracture in Blacks. With the expected increase in older people, osteoporotic fractures will pose a major health problem and screening guidelines needed to be implemented. INTRODUCTION: Developing countries are predicted to bear the burden of osteoporosis in the coming decades. This study was undertaken to review earlier reports that osteoporotic hip fractures are rare in Black Africans...
December 5, 2017: Archives of Osteoporosis
https://www.readbyqxmd.com/read/29207226/-the-treatment-of-the-patient-presenting-with-chronic-kidney-disease-ckd-and-fragility-fractures
#8
REVIEW
Andrea Giusti, Maria Fusaro
Fragility fractures occur in all stages of chronic kidney disease (CKD) due to low bone mineral density and poor bone quality (namely osteoporosis), as well as in CKD-mineral and bone disorders (CKD-MBD). As in postmenopausal women and older adults, the prompt identification of CKD subjects with a history of fragility fractures is crucial in order to implement strategies to reduce the risk of new fragility fractures and their consequences. The treatment of severe osteoporosis for patients with stages 1-3 CKD should not differ from patients without CKD, while clinical decisions and pharmacological treatments in subjects with stages 4-5/5D CKD differ greatly, being more tricky and challenging...
December 5, 2017: Giornale Italiano di Nefrologia: Organo Ufficiale Della Società Italiana di Nefrologia
https://www.readbyqxmd.com/read/29207221/-therapy-of-glucocorticoid-induced-osteoporosis
#9
REVIEW
Marta Arazzi, Giorgia Di Fulvio, Lorenzo Ottavio Di Pietro, Xhensila Grabocka, Maria Olimpia Longo, Gabriella Micioni, Alessandro Pezzutto, Luca Piscitani, Alessandra Schiazza, Simona Silvestri, Giacinta Vigilante, Luigi Amoroso, Mario Bonomini
Glucocorticoid-induced osteoporosis (GIO) is a major cause of secondary osteoporosis that starts early after the beginning of therapy even for low drug doses. Glucocorticoids are used for the treatment of immunologic nephropathies and in the setting of kidney transplant. In clinical practice, a number of algorithms are available; they allow us to estimate the long-term risk of major osteoporotic fracture; but none of them is specific for GIO. To date, the therapeutic approach comprises both general measures aimed at correcting calcium and vitamin D intake, and drugs (bisphosphonates, teriparatide, hormone replacement therapy, denosumab) that ameliorate bone mineral density and patient outcomes...
December 5, 2017: Giornale Italiano di Nefrologia: Organo Ufficiale Della Società Italiana di Nefrologia
https://www.readbyqxmd.com/read/29207050/in-vitro-cell-behaviors-of-bone-mesenchymal-stem-cells-derived-from-normal-and-postmenopausal-osteoporotic-rats
#10
Qian Liu, Xiaoxia Zhang, Yang Jiao, Xin Liu, Yirong Wang, Song-Lun Li, Wei Zhang, Fa-Ming Chen, Yin Ding, Chuan Jiang, Zuolin Jin
Postmenopausal osteoporosis (PMO) increases bone fragility and the risk of fractures, and impairs the healing procedure of bone defects in aged women. The stromal cell‑derived factor-1α (SDF-1α)/CXC chemokine receptor type 4 (CXCR4) axis helps to maintain the biological and physiological functions of bone marrow mesenchymal stem cells (BMSCs) and increase the homing efficiency of BMSCs. The present study aimed to provide insights into the possible association between migration and osteogenic ability and the SDF-1α/CXCR4 axis in BMSCs derived from a rat model of PMO...
November 22, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29204116/p2y12-receptor-antagonist-clopidogrel-does-not-contribute-to-risk-of-osteoporotic-fractures-in-stroke-patients
#11
Niklas R Jørgensen, Peter Schwarz, Helle K Iversen, Peter Vestergaard
Background: Stroke is a leading cause of mortality and morbidity. It is associated with excessive bone loss and risk of fracture in stroke patients is high. The P2Y12R antagonist and platelet inhibitor, clopidogrel, is widely used for secondary prevention after a stroke. However, recent studies have shown that clopidogrel has negative effects on bone and that long-term clopidogrel use is associated with increased fracture risk. The purpose of the current study was therefore to investigate the association of clopidogrel treatment with risk of fractures in stroke and TIA patients...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29201847/the-efficacy-of-fentanyl-transdermal-patch-as-the-first-line-medicine-for-the-conservative-treatment-of-osteoporotic-compression-fracture
#12
June Ho Choi, Hui Dong Kang, Jin Hoon Park, Bon Sub Gu, Sang Ku Jung, Se Hyun Oh
Objective: There are no strong guidelines on how long or how we should undertake conservative treatment during the acute period of an osteoporotic vertebral compression fracture (VCF). Methods: We treated 202 patients with conservative treatment on VCF from March 2012 to August 2015. On inclusion criteria, 75 patients (22 males and 53 females) were included in the final analysis. After admission, a transdermal fentanyl patch with low dose (12.5 µg) application was attempted in all patients...
October 2017: Korean Journal of Neurotrauma
https://www.readbyqxmd.com/read/29201578/vertebral-compression-fractures-after-lumbar-instrumentation
#13
Michelle Granville, Aldo Berti, Robert E Jacobson
Lumbar spinal stenosis (LSS) is primarily found in an older population. This is a similar demographic group that develops both osteoporosis and vertebral compression fractures (VCF). This report reviewed a series of patients treated for VCF that had previous lumbar surgery for symptomatic spinal stenosis. Patients that only underwent laminectomy or fusion without instrumentation had a similar distribution of VCF as the non-surgical population in the mid-thoracic, or lower thoracic and upper lumbar spine. However, in the patients that had previous short-segment spinal instrumentation, fractures were found to be located more commonly in the mid-lumbar spine or sacrum adjacent to or within one or two spinal segments of the spinal instrumentation...
September 29, 2017: Curēus
https://www.readbyqxmd.com/read/29201155/critical-issues-and-current-challenges-in-osteoporosis-and-fracture-prevention-an-overview-of-unmet-needs
#14
REVIEW
Willem F Lems, Hennie G Raterman
Osteoporosis is a silent disease with increasing prevalence due to the global ageing population. Decreased bone strength and bone quality is the hallmark of osteoporosis which leads to an increased risk of fragility fractures in elderly. It has been estimated that approximately ~50% of women will suffer during their lifetime from an osteoporotic fracture. This must be considered as a major health concern, as it has previously been established that fragility fracture has been associated with decreased quality of life due to increased disability, more frequent hospital admission and most importantly, osteoporotic fractures have been related to an augmented mortality risk...
December 2017: Therapeutic Advances in Musculoskeletal Disease
https://www.readbyqxmd.com/read/29200483/biomechanical-analysis-of-range-of-motion-and-failure-characteristics-of-osteoporotic-spinal-compression-fractures-in-human-cadaver
#15
Robert F Heary, Naresh K Parvathreddy, Nitin Agarwal
Background: Vertebroplasty is a treatment for osteoporotic vertebral compression fractures. The optimal location of needle placement for cement injection remains a topic of debate. As such, the authors assessed the effects of location of two types of cement instillations. In addition, the motion and failure modes at the index and adjacent segments were measured. Materials and Methods: Seven human osteoporotic cadaver spines (T1-L4), cut into four consecutive vertebral segments, were utilized...
November 2017: Indian Journal of Orthopaedics
https://www.readbyqxmd.com/read/29199188/cost-effective-osteoporosis-treatment-thresholds-for-people-living-with-hiv-infection-in-greece
#16
P Makras, N Boubouchairopoulou, I Katsarolis, K Athanasakis
OBJECTIVES: We aimed to specifically define the FRAX-based cost-effective treatment thresholds for osteoporosis among people living with HIV (PLWHIV) in Greece and to compare them with those of the general population. METHODS: A previously described state transition Markov cohort model was used in order to estimate the cost-effective intervention thresholds for osteoporotic therapy among Greek PLWHIV employing the FRAX® tool. The model-derived relative risk at which an incremental cost-effectiveness ratio of 30,000€/QALY gained was observed for treatment versus no intervention was multiplied by the average Greek FRAX-based 10-year probabilities for both major osteoporotic and hip fractures...
December 1, 2017: Journal of Musculoskeletal & Neuronal Interactions
https://www.readbyqxmd.com/read/29199087/primary-total-knee-arthroplasty-for-acute-fracture-around-the-knee
#17
REVIEW
S Parratte, M Ollivier, J-N Argenson
Relatively poor results have been reported with open reduction and internal fixation of complex fractures around the knee in elderly osteoporotic patients, and primary total knee arthroplasty (TKA) has been proposed as an alternative solution. While limiting the number of procedures, it meets two prerequisites: 1) to save the patient's life, thanks to early weight-bearing, to limit decubitus complications; and 2) to save knee function and patient autonomy, thanks to early knee mobilization. There are 3 main indications: complex articular fractures in elderly patients with symptomatic osteoarthritis prior to fracture; complex articular fractures of the tibial plateau in elderly patients whose bone quality makes internal fixation hazardous; and major destruction of the distal femur in younger patients...
November 30, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/29198979/bone-volume-fraction-and-structural-parameters-for-estimation-of-mechanical-stiffness-and-failure-load-of-human-cancellous-bone-samples-in-vitro-comparison-of-ultrasound-transit-time-spectroscopy-and-x-ray-%C3%AE-ct
#18
Ali Hamed Alomari, Marie-Luise Wille, Christian M Langton
Conventional mechanical testing is the 'gold standard' for assessing the stiffness (N mm-1) and strength (MPa) of bone, although it is not applicable in-vivo since it is inherently invasive and destructive. The mechanical integrity of a bone is determined by its quantity and quality; being related primarily to bone density and structure respectively. Several non-destructive, non-invasive, in-vivo techniques have been developed and clinically implemented to estimate bone density, both areal (dual-energy X-ray absorptiometry (DXA)) and volumetric (quantitative computed tomography (QCT))...
November 30, 2017: Bone
https://www.readbyqxmd.com/read/29197306/commentary-on-internal-medicine-hospitalists-perceived-barriers-and-recommendations-for-optimizing-secondary-prevention-of-osteoporotic-hip-fractures
#19
Deborah A Humphrey
No abstract text is available yet for this article.
December 2017: Southern Medical Journal
https://www.readbyqxmd.com/read/29197305/internal-medicine-hospitalists-perceived-barriers-and-recommendations-for-optimizing-secondary-prevention-of-osteoporotic-hip-fractures
#20
Eng Keong Tan, Kah Poh Loh, Sarah L Goff
OBJECTIVES: Osteoporosis is a major public health concern affecting an estimated 10 million people in the United States. To the best of our knowledge, no qualitative study has explored barriers perceived by medicine hospitalists to secondary prevention of osteoporotic hip fractures. We aimed to describe these perceived barriers and recommendations regarding how to optimize secondary prevention of osteoporotic hip fracture. METHODS: In-depth, semistructured interviews were performed with 15 internal medicine hospitalists in a tertiary-care referral medical center...
December 2017: Southern Medical Journal
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