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osteoporotic fractures

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https://www.readbyqxmd.com/read/28329858/cystatin-c-and-the-risk-of-frailty-and-mortality-in-older-men
#1
Allyson Hart, Terri L Blackwell, Misti L Paudel, Brent C Taylor, Eric S Orwoll, Peggy M Cawthon, Kristine E Ensrud
Background: This study examines the association between cystatin C (cysC) levels and risks of progression of frailty status or death in older men. Methods: Prospective study of 2,613 men without overt frailty aged 67 years and older enrolled in the MrOS ancillary sleep study. Baseline measurements included serum cysC, serum creatinine, and frailty status. Repeat frailty status, performed an average of 3.4 years later, was assessed as an ordinal outcome of robust, intermediate stage (prefrail), frail or dead...
November 9, 2016: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28329356/sleep-disturbances-and-risk-of-hospitalization-and-inpatient-days-among-older-women
#2
Misti L Paudel, Brent C Taylor, Tien N Vo, Allyson M Kats, John T Schousboe, Li-Yung Lui, Charles E McCulloch, Lisa Langsetmo, Sonia Ancoli-Israel, Susan Redline, Kristine Yaffe, Katie L Stone, Teresa A Hillier, Kristine E Ensrud
Study Objective: Determine the associations of sleep disturbances with hospitalization risk among older women. Methods: 1,827 women (mean age 83.6 years) participating in Study of Osteoporotic Fractures Year 16 (Y16) examination (2002-2004) linked with Medicare and/or HMO claims. At Y16 examination, sleep/wake parameters were measured by actigraphy (total sleep time [TST], sleep efficiency [SE], sleep latency [SL], and wake after sleep onset [WASO]) and subjective sleep measures (sleep quality [Pittsburgh Sleep Quality Index] and daytime sleepiness [Epworth Sleepiness Scale]) were assessed by questionnaire...
March 1, 2017: Sleep
https://www.readbyqxmd.com/read/28329087/clinical-definitions-of-sarcopenia-and-risk-of-hospitalization-in-community-dwelling-older-men-the-osteoporotic-fractures-in-men-study
#3
Peggy M Cawthon, Li-Yung Lui, Brent C Taylor, Charles E McCulloch, Jane A Cauley, Jodi Lapidus, Eric Orwoll, Kristine E Ensrud
Background: The association between various definitions of sarcopenia and hospitalization has not been evaluated in community-dwelling older men. Methods: We used data from 1,516 participants at Visit 3 of the Osteoporotic Fractures in Men (MrOS) study who also had linked Medicare Fee-For-Service Claims data available. We examined the association between several sarcopenia definitions (International Working Group, European Working Group for Sarcopenia in Older Persons, Foundation for the NIH Sarcopenia Project, Baumgartner, and Newman) and hospitalization, using two-part ("hurdle") models, adjusted for age, clinical center, functional limitations, self-reported health, comorbidity, and cognitive function...
January 18, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28326612/serum-phosphate-and-cognitive-function-in-older-men
#4
Yelena Slinin, Tien Vo, Brent C Taylor, Anne M Murray, John Schousboe, Lisa Langsetmo, Kristine Ensrud
OBJECTIVE: Determine whether serum phosphate is associated with concurrent cognitive impairment and subsequent cognitive decline in older men independent of demographic covariates and atherosclerotic risk factors. METHODS: In a prospective study of 5529 men enrolled in the Osteoporotic Fractures in Men study, we measured baseline serum phosphate, baseline cognitive function, and change in cognitive function between baseline and follow-up exams an average of 4.6 years later using the Modified Mini-Mental State (3MS) Examination and Trails B...
March 22, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28326418/combining-a-hip-arthroplasty-stem-with-trochanteric-reattachment-bolt-and-a-polyaxial-locking-plate-in-the-treatment-of-a-periprosthetic-fracture-below-a-well-integrated-implant
#5
Urban Hedlundh, Lars Karlsson
Distally anchored uncemented modular tapered porous stems are often the preferred treatment in total hip arthroplasty revisions and failed subtrochanteric fractures. These conditions mainly affect elderly osteoporotic patients, with an increased risk of later fractures below the well-fixated implant. Treatment in secondary fractures with long looking plates is the recommended treatment, where stability is a key to fracture healing. We report a complicated case in which this was achieved by an innovative technique combing the trochanteric attachment bolt of the stem system and a locking plate with polyaxial screws...
December 2016: Arthroplasty Today
https://www.readbyqxmd.com/read/28326338/predictors-of-teriparatide-treatment-failure-in-patients-with-low-bone-mass
#6
Tarig Elraiyah, Adil H Ahmed, Zhen Wang, Joshua N Farr, Mohammad H Murad, Matthew T Drake
INTRODUCTION: While teriparatide is the only skeletal anabolic agent approved in the United States, treatment failure is a major concern which complicates its clinical utility. We sought to identify factors that predict response failure in patients with low bone mass. METHOD: We performed a retrospective study of adults with osteopenia or osteoporosis (T-scores < - 1.0 and - 2.5 SD below normal, respectively, at the total hip or lumbar spine) treated with teriparatide at the Mayo Clinic (Rochester, Minnesota) between November 2002-December 2012...
June 2016: Bone Reports
https://www.readbyqxmd.com/read/28326303/current-role-and-application-of-teriparatide-in-fracture-healing-of-osteoporotic-patients-a-systematic-review
#7
Sang-Min Kim, Kyung-Chung Kang, Ji Wan Kim, Seung-Jae Lim, Myung Hoon Hahn
BACKGROUND: The use of osteoanabolic agents to facilitate fracture healing has been of heightened interest to the field of orthopaedic trauma. This study aimed to evaluate the evidence of teriparatide for fracture healing and functional recovery in osteoporotic patients. METHODS: We performed a literature search in PubMed, EMBASE, Web of Science, and the Cochrane Library using terms including "Fracture" [tiab] AND "Teriparatide [tiab] OR "PTH" [tiab]. RESULTS: This systematic review included 6 randomized clinical trials, 4 well-controlled retrospective studies, and 1 retrospective post hoc subgroup analysis...
February 2017: Journal of Bone Metabolism
https://www.readbyqxmd.com/read/28326300/the-efficacy-of-bisphosphonates-for-prevention-of-osteoporotic-fracture-an-update-meta-analysis
#8
Ji-Hye Byun, Sunmee Jang, Sumin Lee, Suyeon Park, Hyun Koo Yoon, Byung-Ho Yoon, Yong-Chan Ha
BACKGROUND: The efficacy of bisphosphonates for osteoporotic fracture has been consistently reported in recent randomized controlled trials (RCTs) enrolling hundreds of patients. The objective of this study was to update knowledge on the efficacy of available bisphosphonates in the prevention of vertebral and non-vertebral fractures. METHODS: An approach "using systematic reviews" on PubMed and Cochrane Library was taken. Twenty-four RCTs investigating the effects of bisphosphonates for the prevention of osteoporotic fracture were included in final analysis...
February 2017: Journal of Bone Metabolism
https://www.readbyqxmd.com/read/28325144/therapeutic-potential-and-outlook-of-alternative-medicine-for-osteoporosis
#9
Tao Wang, Qian Liu, William Tjhioe, Jinmin Zhao, Aiping Lu, Ge Zhang, Renxiang Tan, Mengyu Zhou, Jiake Xu, Haotian Feng
Osteoporosis, a bone disease resulting in loss of bone density and microstructure quality, is often associated with fragility fractures, and the latter imposes a great burden on the patient and society. Although there are several different treatments available for osteoporosis such as hormone replacement therapy, bisphosphonates, Denosumab, and parathyroid hormone some concern has been raised regarding the inherent side effects of their long term use. It would be of great relevance to search for alternative natural compounds, which could complementarily overcome the limitations of the currently available therapy...
March 21, 2017: Current Drug Targets
https://www.readbyqxmd.com/read/28324215/surgical-treatment-of-osteoporotic-thoraco-lumbar-compressive-fractures-the-use-of-pedicle-screw-with-augmentation-pmma
#10
Massimo Girardo, P Cinnella, G Gargiulo, P Viglierchio, A Rava, S Aleotti
INTRODUCTION: The osteoporosis prevalence in population is age related. The aim of this single-center observational study was evaluate the middle- to long-term performance of cement (PMMA) augmented fenestrated pedicle screws in elderly patients with thoraco-lumbar compressive fractures by osteoporosis. MATERIALS AND METHODS: From 2011 to 2015 we treated 52 patients (20 males and 32 females) suffering from somatic osteoporotic fractures (T10-L2). The average age was 73...
March 21, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28324124/osteoporosis-in-frail-patients-a-consensus-paper-of-the-belgian-bone-club
#11
REVIEW
E Gielen, P Bergmann, O Bruyère, E Cavalier, P Delanaye, S Goemaere, J-M Kaufman, M Locquet, J-Y Reginster, S Rozenberg, A-M Vandenbroucke, J-J Body
In this consensus paper, the Belgian Bone Club aims to provide a state of the art on the epidemiology, diagnosis, and management of osteoporosis in frail individuals, including patients with anorexia nervosa, patients on dialysis, cancer patients, persons with sarcopenia, and the oldest old. All these conditions may indeed induce bone loss that is superimposed on physiological bone loss and often remains under-recognized and under-treated. This is of particular concern because of the major burden of osteoporotic fractures in terms of morbidity, mortality, and economic cost...
March 21, 2017: Calcified Tissue International
https://www.readbyqxmd.com/read/28324103/harmonized-reference-ranges-for-circulating-testosterone-levels-in-men-of-four-cohort-studies-in-the-usa-and-europe
#12
Thomas G Travison, Hubert W Vesper, Eric Orwoll, Frederick Wu, Jean Marc Kaufman, Ying Wang, Bruno Lapauw, Tom Fiers, Alvin M Matsumoto, Shalender Bhasin
Background: Reference ranges for testosterone are essential for making a diagnosis of hypogonadism in men. Objective: To establish harmonized reference ranges for total testosterone in men that can be applied across laboratories by cross-calibrating cohort-specific assays to a reference method and standard. Population: 9054 community-dwelling men in cohort studies in the United States and Europe: Framingham Heart Study; European Male Aging Study; Osteoporotic Fractures in Men Study; Male Sibling Study of Osteoporosis...
January 10, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28324091/association-between-dabigatran-vs-warfarin-and-risk-of-osteoporotic-fractures-among-patients-with-nonvalvular-atrial-fibrillation
#13
Wallis C Y Lau, Esther W Chan, Ching-Lung Cheung, Chor Wing Sing, Kenneth K C Man, Gregory Y H Lip, Chung-Wah Siu, Joanne K Y Lam, Alan C H Lee, Ian C K Wong
Importance: The risk of osteoporotic fracture with dabigatran use in patients with nonvalvular atrial fibrillation (NVAF) is unknown. Objective: To investigate the risk of osteoporotic fracture with dabigatran vs warfarin in patients with NVAF. Design, Setting, and Participants: Retrospective cohort study using a population-wide database managed by the Hong Kong Hospital Authority. Patients newly diagnosed with NVAF from 2010 through 2014 and prescribed dabigatran or warfarin were matched by propensity score at a 1:2 ratio with follow-up until July 31, 2016...
March 21, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28323716/clinical-experience-using-a-remote-control-injection-system-in-vertebroplasty-feasibility-safety-and-cement-leakage-of-osteoporotic-and-malignant-compression-fractures
#14
Peng Jin, Xunwei Liu, Min Li, Gang Sun
STUDY DESIGN: A retrospective study. SUMMARY OF BACKGROUND DATA: Cement leakage is a frequent occurrence in vertebroplasty and is also the main source of complications. Continuous radiographic evaluation is mandatory to detect cement leakage during injecting cement into the vertebral body, while the operator is subjected to x-ray radiation exposure. OBJECTIVE: The aim of this study was to evaluate the feasibility and safety of vertebroplasty performed on patients and operators for the treatment of osteoporotic and malignant vertebral compression fractures using a remote control injection system...
April 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28323714/osteointegration-and-resorption-of-intravertebral-and-extravertebral-calcium-phosphate-cement
#15
Roman Klein, Ralf Tetzlaff, Christel Weiss, Meike-Kristina Schäfer, Michael Tanner, Bernd Wiedenhöfer, Ingo Grafe, Peter-Jürgen Meeder, Gerd Noeldge, Peter P Nawroth, Christian Kasperk
STUDY DESIGN: Eleven patients with painful osteoporotic vertebral fractures who underwent kyphoplasty using calcium phosphate (CaP) cement were followed up for 1 week, 1, 2, and 3 years in a monocentric, nonrandomized, noncontrolled retrospective trial. OBJECTIVE: This study investigates long-term radiomorphologic features of intraosseous CaP cement implants and of extraosseous CaP cement leakages for up to 3 years after implantation by kyphoplasty. SUMMARY OF BACKGROUND DATA: Kyphoplasty is frequently used for the treatment of painful osteoporotic fractures...
April 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28323711/effect-of-bone-cement-volume-fraction-on-adjacent-vertebral-fractures-after-unilateral-percutaneous-kyphoplasty
#16
Dasheng Lin, Jianming Hao, Lin Li, Lei Wang, Huantang Zhang, Weitao Zou, Kejian Lian
STUDY DESIGN: A retrospective study. SUMMARY OF BACKGROUND DATA: Complications of the bone cement used in vertebroplasty and kyphoplasty procedures have received increasingly more attention, especially for bone cement volume. OBJECTIVE: The aim of the study was to retrospectively assess the relationship between bone cement volume fraction and adjacent vertebral fracture (AVF) after unilateral percutaneous kyphoplasty (PKP). MATERIALS AND METHODS: Between 2006 and 2011, 495 patients with single-level osteoporotic vertebral compression fracture (OVCF) were surgically treated by unilateral PKP and had completed 12-month follow-up in our hospital...
April 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28323702/effect-of-an-outer-sleeve-on-an-inflatable-balloon-tamp-in-terms-of-height-restoration-under-simulated-physiological-load
#17
Walter C Peppelman, William Beutler, Michael Gordon, Suresh R Chintakunta, Damien O'Halloran, Brandon Bucklen
STUDY DESIGN: An in vitro biomechanical study. OBJECTIVE: The aim of this study was to determine the effect of an optional sleeve on height restoration and compare it with the fracture reduction achieved by a commercially available inflatable bone tamp under simulated physiological load (110 N). SUMMARY OF BACKGROUND DATA: Loss of reduction after bone tamp deflation before cement injection still remains a concern. The optional sleeve surrounds the bone tamp to help maintain height during the kyphoplasty procedure while filling the created cavity with bone cement on the contralateral side...
April 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28323701/cost-effectiveness-analysis-of-percutaneous-vertebroplasty-for-osteoporotic-compression-fractures
#18
Tomoyuki Takura, Misako Yoshimatsu, Hiroki Sugimori, Kenji Takizawa, Yoshiyuki Furumatsu, Hirotaka Ikeda, Hiroshi Kato, Yukihisa Ogawa, Shingo Hamaguchi, Atsuko Fujikawa, Toshihiko Satoh, Yasuo Nakajima
STUDY DESIGN: Single-center, single-arm, prospective time-series study. OBJECTIVE: To assess the cost-effectiveness and improvement in quality of life (QOL) of percutaneous vertebroplasty (PVP). SUMMARY OF BACKGROUND DATA: PVP is known to relieve back pain and increase QOL for osteoporotic compression fractures. However, the economic value of PVP has never been evaluated in Japan where universal health care system is adopted. METHODS: We prospectively followed up 163 patients with acute vertebral osteoporotic compression fractures, 44 males aged 76...
April 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28322449/tgf-%C3%AE-inhibits-osteogenesis-by-upregulating-the-expression-of-ubiquitin-ligase-smurf1-via-mapk-erk-signaling
#19
Xuewu Sun, Ziang Xie, Yan Ma, Xin Pan, Jiying Wang, Zhijun Chen, Peihua Shi
High incidence of osteoporotic fractures emphasizes the necessity of developing effective measures to promote osteogenesis. In our study, we investigated a possible role of MAPK-ERK signaling in the TGF-β-mediated osteoblastic differentiation. Our results indicated that TGF-β activated the MAPK-ERK pathway and inhibited osteogenesis in mesenchymal pluripotent cell line, C3H10T1/2, and preosteoblastic cell line, MC3T3 cells. And the downregulation of MAPK-ERK signaling using pharmacological inhibitor U0126 and RNA interference rescued osteoblast differentiation suppressed by TGF-β, which was confirmed by Alkaline phosphatase (ALP) staining and alizarrn red staining and the enhanced expression of osteogenesic markers...
March 21, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28318949/wing-augmentation-reduces-femoral-head-cutting-out-of-dynamic-hip-screw
#20
Chih-Yu Chen, Shu-Wei Huang, Jui-Sheng Sun, Shin-Yiing Lin, Chih-Sheng Yu, Hsu-Pin Pan, Ping-Hung Lin, Fan-Chun Hsieh, Yang-Hwei Tsuang, Feng-Huei Lin, Rong-Sen Yang, Cheng-Kung Cheng
The dynamic hip screw (DHS) is commonly used in the treatment of femoral intertrochanteric fracture with high satisfactory results. However, post-operative failure does occur and result in poor prognosis. The most common failure is femoral head varus collapse, followed by lag screw cut-out through the femoral head. In this study, a novel-designed DHS with two supplemental horizontal blades was used to improve the fixation stability. In this study, nine convention DHS and 9 Orthopaedic Device Research Center (ODRC) DHSs were tested in this study...
March 17, 2017: Medical Engineering & Physics
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