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https://www.readbyqxmd.com/read/28938751/new-permeable-cryoprotectant-free-vitrification-method-for-native-human-sperm
#1
J Aizpurua, L Medrano, M Enciso, J Sarasa, A Romero, M A Fernández, M J Gómez-Torres
STUDY QUESTION: Is permeable cryoprotectant-free vitrification of native sperm samples a good alternative to conventional slow freezing? SUMMARY ANSWER: The permeable cryoprotectant-free sperm vitrification protocol tested in this study renders considerably better recovery rates of good quality sperm compared to slow freezing. WHAT IS KNOWN ALREADY: Slow freezing is currently the most commonly used technique for sperm cryopreservation, though this method has been repeatedly shown to have negative effects on both structural and functional sperm features...
October 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28938744/an-improved-ivm-method-for-cumulus-oocyte-complexes-from-small-follicles-in-polycystic-ovary-syndrome-patients-enhances-oocyte-competence-and-embryo-yield
#2
F Sánchez, F Lolicato, S Romero, M De Vos, H Van Ranst, G Verheyen, E Anckaert, J E J Smitz
STUDY QUESTION: Are meiotic and developmental competence of human oocytes from small (2-8 mm) antral follicles improved by applying an optimized IVM method involving a prematuration step in presence of C-Type Natriuretic Peptide (CNP) followed by a maturation step in presence of FSH and Amphiregulin (AREG)? SUMMARY ANSWER: A strategy involving prematuration culture (PMC) in the presence of CNP followed by IVM using FSH + AREG increases oocyte maturation potential leading to a higher availability of Day 3 embryos and good-quality blastocysts for single embryo transfer...
October 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28938706/ehj-quality-of-care-and-clinical-outcomes-now-recommended-for-medline-listing
#3
Adam Timmis
No abstract text is available yet for this article.
May 1, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28938392/segmental-bone-loss-reconstruction-using-ring-fixation
#4
Stephen M Quinnan
Ring fixation is a powerful tool in the treatment of bone defects. The ability to create high-quality, biologically normal new bone of even massive proportions using distraction osteogenesis is a major reason for its success. In addition, ring fixation provides the ability to limit the risk of deep infection, improves flexibility in limb length control and alignment, and increases soft tissue coverage options. The drawbacks of ring fixation include long frame times, pin problems, risk of joint contractures, and difficult usage in areas with a large soft tissue envelope such as the thigh...
October 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28938365/why-the-p-value-alone-is-not-enough-the-need-for-confidence-intervals-in-plastic-surgery-research
#5
Osama A Samargandi, Mona Al-Taha, Kit Moran, Sarah Al Youha, Michael Bezuhly
BACKGROUND: The p-value is one of the most utilized descriptors in statistical analysis; however, when reported in isolation, it does not convey the effect size of a treatment. The reporting of confidence intervals (CIs) is an essential adjunct to determine the clinical value of treatment, as it permits an assessment of the effect size. The authors assessed the reporting of CIs in clinical trials within the plastic surgery literature. METHODS: The seven highest impact plastic surgery journals were screened using MEDLINE for clinical trials in the years 2006, 2009, 2012, and 2015...
September 15, 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28938363/reconstruction-of-the-heel-middle-foot-sole-and-plantar-forefoot-with-the-medial-plantar-artery-perforator-mpap-flap-clinical-experience-with-28-cases
#6
Mario F Scaglioni, Daniel Rittirsch, Pietro Giovanoli
INTRODUCTION: Defects in the weight-bearing region of the foot sole can represent a substantial restriction in quality of life and pose a challenge for reconstructive plastic surgery.The purpose of this article is to report our experience with the use of medial plantar artery perforator (MPAP) flap for reconstruction of defects of the foot sole in 3 different regions: heel, middle foot sole and plantar forefoot. PATIENTS AND METHODS: From January 2003 to May 2016, 28 patients (13 males and 15 females) with an average age of 54 years (range 12 to 84 y...
September 15, 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28938360/implant-porosity-and-the-foreign-body-response
#7
Sumanas W Jordan, Jennifer E Fligor, Lindsay E Janes, Gregory A Dumanian
The biocompatibility of prosthetic mesh is dependent on a number of physicochemical properties that ultimately incite an optimal foreign body response (FBR). The magnitude and character of the FBR directly affect the clinical success of the hernia repair, with too little scar resulting in bulge or hernia recurrence and too much scar causing mesh wrinkling and pain. Moreover, it is important to consider the effect of a sustained FBR and scar remodeling on the combined strength of the mesh-tissue construct over time...
September 15, 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28938340/paediatric-traumatic-brain-injury-prognostic-insights-and-outlooks
#8
Alicia K Au, Robert S B Clark
PURPOSE OF REVIEW: Traumatic brain injury (TBI) is a leading cause of death and disability in children. Prognostication of outcome following TBI is challenging in this population and likely requires complex, multimodal models to achieve clinically relevant accuracy. This review highlights injury characteristics, physiological indicators, biomarkers and neuromonitoring modalities predictive of outcome that may be integrated for future development of sensitive and specific prognostic models...
September 21, 2017: Current Opinion in Neurology
https://www.readbyqxmd.com/read/28938300/enhancing-the-quality-and-safety-of-the-perioperative-patient
#9
Sven Staender, Andrew Smith
PURPOSE OF REVIEW: Many possible hazards bedevil the perioperative patient. This review focuses on a number of aspects of perioperative management where the patient's quality and safety can be enhanced. RECENT FINDINGS: Our understanding of the relationship between preoperative preparation and postoperative outcomes has improved. There have also been recent developments in our understanding of how to construct useful cognitive aids and make the best use of checklists by understanding the cultural environment supporting their use...
September 21, 2017: Current Opinion in Anaesthesiology
https://www.readbyqxmd.com/read/28938242/clinical-data-warehouse-an-effective-tool-to-create-intelligence-in-disease-management
#10
Mahtab Karami, Azin Rahimi
Clinical business intelligence tools such as clinical data warehouse enable health care organizations to objectively assess the disease management programs that affect the quality of patients' life and well-being in public. The purpose of these programs is to reduce disease occurrence, improve patient care, and decrease health care costs. Therefore, applying clinical data warehouse can be effective in generating useful information about aspects of patient care to facilitate budgeting, planning, research, process improvement, external reporting, benchmarking, and trend analysis, as well as to enable the decisions needed to prevent the progression or appearance of the illness aligning with maintaining the health of the population...
September 21, 2017: Health Care Manager
https://www.readbyqxmd.com/read/28938234/is-early-total-care-a-safe-and-effective-alternative-to-staged-protocol-for-the-treatment-of-schatzker-iv-vi-tibial-plateau-fractures-in-patients-older-than-50-years
#11
Amrut Borade, Harish Kempegowda, Raveesh Richard, Jove Graham, Michael Suk, Daniel S Horwitz
OBJECTIVES: To compare "Early Total Care" (ETC) with "Staged Protocol" (SP) for the treatment of Schatzker IV-VI tibial plateau fractures in patients older than 50 years regarding safety and effectiveness. DESIGN: Retrospective cohort study. SETTING: An academic level 1 US trauma center. PATIENTS/PARTICIPANTS: Eighty-one patients older than 50 years with Schatzker grade IV-VI tibial plateau fractures were included. INTERVENTION: Fifty-three patients were treated under SP with immediate external fixation followed by definitive internal fixation...
September 19, 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28937896/evaluation-of-oral-health-related-quality-of-life-to-assess-dental-treatment-in-preschool-children-with-early-childhood-caries-a-preliminary-study
#12
Ana Lúcia Vollú, Maria da Encarnação Perez Requejo da Costa, Lucianne Cople Maia, Andréa Fonseca-Gonçalves
PURPOSE: The oral health-related quality of life (OHRQoL) of preschool children with Early Childhood Caries (ECC) was used to assess the outcome of dental treatment. STUDY DESIGN: Children (3.56±1.31years) affected by ECC were selected. Anamnesis, clinical and radiographic exams were performed. Data about sociodemographic aspects, OHRQoL and dmf-t index were collected. The Brazilian version of Early Childhood Oral health Impact Scale (B-ECOHIS) was applied in two time intervals: before and after 30 days of treatment...
September 22, 2017: Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/28937705/interventions-for-treating-genital-chlamydia-trachomatis-infection-in-pregnancy
#13
REVIEW
Catherine Cluver, Natalia Novikova, David Oa Eriksson, Kevin Bengtsson, Göran K Lingman
BACKGROUND: Genital Chlamydia trachomatis (C.trachomatis) infection may lead to pregnancy complications such as miscarriage, preterm labour, low birthweight, preterm rupture of membranes, increased perinatal mortality, postpartum endometritis, chlamydial conjunctivitis and C.trachomatis pneumonia.This review supersedes a previous review on this topic. OBJECTIVES: To establish the most efficacious and best-tolerated therapy for treatment of genital chlamydial infection in preventing maternal infection and adverse neonatal outcomes...
September 22, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28937639/sleep-disorders-in-childhood-neurological-diseases
#14
REVIEW
Abdullah Tolaymat, Zhao Liu
Sleep problems are frequently addressed as a primary or secondary concern during the visit to the pediatric neurology clinic. Sleep disorders can mimic other neurologic diseases (e.g., epilepsy and movement disorders), and this adds challenges to the diagnostic process. Sleep disorders can significantly affect the quality of life and functionality of children in general and those with comorbid neurological diseases in particular. Understanding the pathophysiology of sleep disorders, recognizing the implications of sleep disorder in children with neurologic diseases and behavioral difficulties, and early intervention continue to evolve resulting in better neurocognitive outcomes...
September 22, 2017: Children
https://www.readbyqxmd.com/read/28937506/role-of-lens-extraction-and-laser-peripheral-iridotomy-in-treatment-of-glaucoma
#15
Sara Pose-Bazarra, Augusto Azuara-Blanco
PURPOSE OF REVIEW: Lens extraction in people with coexisting cataract and open angle glaucoma is associated with a reduction in intraocular pressure (IOP). In primary angle-closure glaucoma (PACG), lens extraction and laser peripheral iridotomy (LPI) can be used to open the anterior chamber angle, increase the outflow through the trabecular meshwork and reduce the IOP. The present review will summarize the recent available literature regarding the role of both interventions for the treatment of glaucoma...
September 20, 2017: Current Opinion in Ophthalmology
https://www.readbyqxmd.com/read/28937505/measuring-outcomes-in-cataract-surgery
#16
Vivian L Qin, Felipe F Conti, Rishi P Singh
PURPOSE OF REVIEW: The article presents a review of recently published studies reporting postcataract surgery outcomes and the use of electronic systems to track them. RECENT FINDINGS: Current publications report several parameters to measure cataract outcomes such as visual acuity, patient-reported visual function, contrast sensitivity, reading speed, residual refractive errors and complications (intraoperative and postoperative). SUMMARY: Cataracts currently afflict an estimated 94 million people worldwide, and surgical removal is the only effective therapy known...
September 20, 2017: Current Opinion in Ophthalmology
https://www.readbyqxmd.com/read/28937486/iterative-metallic-artifact-reduction-for-in-plane-gonadal-shielding-during-computed-tomographic-venography-of-young-males
#17
Jin Woo Choi, Sang Yub Lee, Jong Hyo Kim, Hyeongmin Jin, Jaewon Lee, Young Hun Choi, Hyeon-Kyeong Lee, Jae Hyung Park
OBJECTIVE: The purpose of this study was to evaluate a gonadal shield (GS) and iterative metallic artifact reduction (IMAR) during computed tomography scans, regarding the image quality and radiation dose. METHODS: A phantom was imaged with and without a GS. Prospectively enrolled, young male patients underwent lower extremity computed tomography venography (precontrast imaging without the GS and postcontrast imaging with the GS). Radiation dose was measured each time, and the GS-applied images were reconstructed by weighted filtered back projection and IMAR...
September 20, 2017: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/28937334/optimal-threshold-estimator-of-a-prognostic-marker-by-maximizing-a-time-dependent-expected-utility-function-for-a-patient-centered-stratified-medicine
#18
Etienne Dantan, Yohann Foucher, Marine Lorent, Magali Giral, Philippe Tessier
Defining thresholds of prognostic markers is essential for stratified medicine. Such thresholds are mostly estimated from purely statistical measures regardless of patient preferences potentially leading to unacceptable medical decisions. Quality-Adjusted Life-Years are a widely used preferences-based measure of health outcomes. We develop a time-dependent Quality-Adjusted Life-Years-based expected utility function for censored data that should be maximized to estimate an optimal threshold. We performed a simulation study to compare estimated thresholds when using the proposed expected utility approach and purely statistical estimators...
October 20, 2016: Statistical Methods in Medical Research
https://www.readbyqxmd.com/read/28937274/visualization-of-the-lumbar-nerve-using-reduced-field-of-view-diffusion-tensor-imaging
#19
Yawara Eguchi, Hirohito Kanamoto, Sumihisa Orita, Kazuhide Inage, Kazuki Fujimoto, Yasuhiro Shiga, Koki Abe, Masahiro Inoue, Hideyuki Kinoshita, Koji Matsumoto, Yoshitada Masuda, Masao Koda, Yasuchika Aoki, Yasuhiro Oikawa, Kazuhisa Takahashi, Seiji Ohtori, Takeo Furuya, Atsuya Watanabe
OBJECTIVE: We investigated high resolution diffusion tensor imaging (DTI) of lumbar nerves with reduced field-of-view (rFOV) using 3-Tesla MRI. METHODS: DTI measured with rFOV was compared with conventional FOV (cFOV) 3.0 T MRI in 5 healthy volunteers and 10 patients with degenerative lumbar disorders. The intracanal, foramina, and extraforamina of the L5 nerve were established as the regions-of-interest (ROI) and fractional anisotropy (FA) values and apparent diffusion coefficient (ADC) values were measured...
September 13, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28937270/feasibility-of-free-breathing-lung-mri-for-radiotherapy-using-non-cartesian-k-space-acquisition-schemes
#20
Shivani Kumar, Robba Rai, Alto Stemmer, Sonal Josan, Lois Holloway, Shalini Vinod, Daniel Moses, Gary Liney
OBJECTIVES: To test a free breathing MRI protocol for anatomical and functional assessment during lung cancer radiotherapy by assessing two non-cartesian acquisition schemes based on a T1W 3D gradient recall echo sequence: (i) stack-of stars (StarVIBE) and (ii) spiral (SpiralVIBE) trajectories Methods: MR images on five healthy volunteers were acquired on a wide bore 3T scanner (Skyra, Siemens Healthcare). Anatomical image quality was assessed on: (1) free breathing (StarVIBE), (2) the standard clinical sequence (VIBE) acquired in a 20 second compliant breath-hold and (3) 20 second non-complaint breath-hold...
September 13, 2017: British Journal of Radiology
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