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https://www.readbyqxmd.com/read/29141313/-tocilizumab-for-refractory-systemic-juvenile-idiopathic-arthritis
#1
J M Lai, F Q Wu, Z X Zhou, M Kang, X L Huang, G X Su, S N Li, J Zhu, X N Wang
Objective: To evaluate the efficacy and side effects of tocilizumab for the treatment of systemic juvenile idiopathic arthritis. Method: In this prospective self case-control study, the children diagnosed with refractory systemic juvenile idiopathic arthritis admitted to Department of Rheumatism and Immunology of Children's Hospital Affiliated to Capital Institute of Pediatrics from December 2013 to June 2016 were enrolled and information before and after treatment of tocilizumab was analyzed. The tocilizumab was introvenously guttae in a dose of 8-12 mg/kg every 2 weeks...
November 2, 2017: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/29139035/certolizumab-pegol-in-the-treatment-of-psoriasis-and-psoriatic-arthritis-preliminary-real-life-data
#2
Annunziata Dattola, Maria Vittoria Cannizzaro, Mauro Mazzeo, Luca Bianchi
INTRODUCTION: We present the results of real-life tests conducted in adults affected by psoriatic arthritis (PsA) with mild cutaneous involvement to evaluate the efficacy of certolizumab pegol (CZP), an anti-tumor necrosis factor-alpha agent approved in Europe for the treatment of rheumatoid arthritis and PsA. METHODS: Assessments included an evaluation of the Psoriasis Area and Severity Index (PASI) and the Disease Activity Score computed on 44 joints (DAS-44) correlated to the erythrocyte sedimentation rate (ESR) (DAS44-ESR)...
November 14, 2017: Dermatology and Therapy
https://www.readbyqxmd.com/read/29134513/current-concepts-and-unmet-needs-in-psoriatic-arthritis
#3
Farrouq Mahmood, Laura C Coates, Philip S Helliwell
Psoriatic arthritis is a chronic inflammatory arthritis that is part of the spondyloarthropathy group of rheumatic diseases and has associated co-morbidities. It can present with various clinical manifestations making diagnosis and treatment challenging, resulting in significant disability and reduced quality of life for patients. Whilst there have been advances in understanding the pathogenic mechanisms of the disease which have resulted in targeted therapies, there is still the need for further studies as some patients fail or are intolerant of current therapies...
November 13, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/29131037/paradoxical-reactions-anti-tumor-necrosis-factor-alpha-agents-ustekinumab-secukinumab-ixekizumab-and-others
#4
Lluís Puig
Paradoxical reactions during treatment with a biologic agent can be defined as the appearance or exacerbation of a pathological condition that usually responds to this class of drug while treating a patient for another condition, which usually remains under control (even though there may be a change in morphology or phenotype). Paradoxical reactions were initially described as isolated case reports or case series in patients treated with anti-tumor necrosis factor (TNF) α agents, first in inflammatory rheumatic diseases, later in psoriasis and inflammatory bowel disease...
2018: Current Problems in Dermatology
https://www.readbyqxmd.com/read/29116543/remission-assessment-of-rheumatoid-arthritis-in-daily-practice-in-china-a-cross-sectional-observational-study
#5
Huaqun Zhu, Ru Li, Zhanyun Da, Liqi Bi, Xiangpei Li, Yang Li, Chongyang Liu, Fengxiao Zhang, Zhijun Li, Xiangyuan Liu, Zhiyi Zhang, Lingyun Sun, Youlian Wang, Wei Zhang, Quan Jiang, Jinwei Chen, Qingping Chen, Zhenbin Li, Lijun Wu, Wencheng Qi, Jianhua Xu, Xiangjun Cui, Xiaofei Wang, Long Li, Xiaomei Leng, Guochun Wang, Dongbao Zhao, Lindi Jiang, Dongyi He, Xiaomin Liu, Ling Li, Yongfei Fang, Cibo Huang, Huaxiang Wu, Shaoxian Hu, Qin Li, Hui Song, Weiguo Xiao, Lu Gong, Liaojia Zhang, Xiaofeng Li, Zhanguo Li, Yin Su
The objective of this study is to evaluate the remission rate and describe the current use of medication in a large cohort of rheumatoid arthritis (RA) patients under routine clinical care in China. RA patients were recruited from 40 large teaching hospitals nationwide in China. Data regarding RA disease activity, medication treatment, and adverse events were recorded using a standardized clinical data questionnaire. RA remission was evaluated by the 28 Joint Disease Activity Score DAS28-ESR Clinical Disease Activity Index (CDAI), Simplified Disease Activity Index (SDAI), and American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) remission criteria...
November 7, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/29116386/clinical-and-ultrasonographic-enthesopathy-in-inflammatory-rheumatic-diseases-is-masei-or-only-calcaneal-enthesitis-sufficient
#6
Ekrem Süleyman, Kemal Nas, Halil Harman, Nedim Kaban
AIM: We aimed at investigating the ultrasonographic (US) and clinical prevalence of enthesopathy in patients with rheumatoid arthritis (RA), and axial spondyloarthropathy (SpA), as well as the correlation between this condition and disease activity, along with the quality of life. METHODS: Included in the study were 30 axial SpA, 21 patients with RA, and 25 healthy cases. Bath Anklylosing Spondylitis Disease Activity Index (BASDAI), Ankylosing Spondylitis Quality of Life (ASQoL), Disease activity index  28 (DAS28), and Health Assessment Questionnaire (HAQ) were used for clinical evaluation, and enthesal pain was evaluated by VAS, whereas enthesitis US evaluation was performed by using the MAdrid Sonographic Enthesitis Index (MASEI)...
November 7, 2017: Zeitschrift Für Rheumatologie
https://www.readbyqxmd.com/read/29112801/value-of-rapid3-in-patients-with-psa-results-from-the-ticopa-and-lopas-ii-databases
#7
Laura C Coates, William Tillett, Gavin Shaddick, Theodore Pincus, Arthur Kavanaugh, Philip S Helliwell
OBJECTIVE: To analyze RAPID3, a patient-reported, composite index, designed initially for feasibility in clinical care. RAPID3 was developed in rheumatoid arthritis, but has been found useful in many rheumatic diseases. We analysed RAPID3 in patients with psoriatic arthritis (PsA). METHODS: Post-hoc analyses were performed on two independent datasets, the tight control of PsA (TICOPA) clinical trial, and the long-term outcome in PsA study (LOPAS II), an observational cohort...
November 7, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/29104539/annonaceae-breaking-the-wall-of-inflammation
#8
REVIEW
Ali Attiq, Juriyati Jalil, Khairana Husain
Inventories of tropical forests have listed Annonaceae as one of the most diverse plant families. For centuries, it is employed in traditional medicines to cure various pathological conditions including snakebite, analgesic, astringent, diarrhea, dysentery, arthritis pain, rheumatism, neuralgia, and weight loss etc. Phytochemical analysis of Annonaceae family have reported the occurrence of alkaloids, flavonoids, triterpenes, diterpenes and diterpene flavone glycosides, sterols, lignans, and annonaceous acetogenin characteristically affiliated with Annonaceae sp...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29103180/safety-of-weekly-adalimumab-in-the-treatment-of-juvenile-idiopathic-arthritis-and-pediatric-chronic-uveitis
#9
Colleen K Correll, Danielle R Bullock, Rachel M Cafferty, Richard K Vehe
Weekly adalimumab dosing is used to treat juvenile idiopathic arthritis (JIA), uveitis, and other pediatric rheumatic diseases, but the safety of such dosing has not previously been studied. A retrospective chart review was conducted to assess the safety of weekly adalimumab. Demographic and clinical data were collected. Basic descriptive analysis was performed to assess for adverse events from weekly adalimumab. Sixty-nine patients at the University of Minnesota or Gillette Children's Hospital were identified as treated with weekly adalimumab...
November 4, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/29103073/the-efficacy-of-tai-chi-and-yoga-in-rheumatoid-arthritis-and-spondyloarthropathies-a-narrative-biomedical-review
#10
REVIEW
Gulseren Akyuz, Ozge Kenis-Coskun
Rheumatoid arthritis (RA) and spondyloarthropathies (SpA) are among the most common inflammatory rheumatic diseases, which might induce chronic pain for their sufferers. Mind-body interventions like Tai Chi and yoga are among the many alternative therapies for combatting chronic pain. This review aims to overview the articles about their effectiveness in RA and SpA. We searched PubMed/MEDLINE, Scopus, and Web of Science for English-language sources from their inception through September 2017. Case-control studies, interventional studies, and case series that included more than three cases and randomized crossover studies were included...
November 4, 2017: Rheumatology International
https://www.readbyqxmd.com/read/29102955/development-and-psychometric-validation-of-a-patient-reported-outcome-measure-to-assess-fears-in-rheumatoid-arthritis-and-axial-spondyloarthritis-the-fear-assessment-in-inflammatory-rheumatic-diseases-fair-questionnaire
#11
Laure Gossec, Pierre Chauvin, Alain Saraux, Christophe Hudry, Gabrielle Cukierman, Thibault de Chalus, Caroline Dreuillet, Vincent Saulot, Sabine Tong, Françoise Russo-Marie, Jean-Michel Joubert, Francis Berenbaum
OBJECTIVES: To develop and validate an outcome measure for assessing fears in patients with rheumatoid arthritis (RA) and axial spondyloarthritis (axSpA). METHODS: Fears were identified in a qualitative study, and reformulated as assertions with which participants could rate their agreement (on a 0-10 numeric rating scale). A cross-sectional validation study was performed including patients diagnosed with RA or axSpA. Redundant items (correlation >0.65) were excluded...
November 4, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29102587/quality-of-life-in-ecuadorian-patients-with-rheumatoid-arthritis-a-cross-sectional-study
#12
Yessenia Cruz-Castillo, Nadia Montero, Rosa Salazar-Ponce, Rómulo Villacís-Tamayo
OBJECTIVES: To evaluate health-related quality of life (HRQoL) and associated clinical, demographic and socioeconomic factors in a cohort of Ecuadorian patients with rheumatoid arthritis (RA). PATIENTS AND METHODS: A cross-sectional descriptive study evaluating (HRQoL) with the Spanish version of the Quality of Life Rheumatoid Arthritis (QoL-RA) instrument in patients diagnosed with RA according to the criteria of the American College of Rheumatology and the European League Against Rheumatism...
November 1, 2017: Reumatología Clinica
https://www.readbyqxmd.com/read/29096708/family-resilience-and-adaptive-coping-in-children-with-juvenile-idiopathic-arthritis-protocol-for-a-systematic-review
#13
Sophia Saetes, Lisa Hynes, Brian E McGuire, Line Caes
BACKGROUND: This systematic review is the first step in a study investigating the resilience methods and processes in families of children with juvenile idiopathic arthritis. In particular, this review will focus on chronic or persistent pain, as a common symptom of juvenile idiopathic arthritis, which is the most common rheumatic disease in childhood. The experience of persistent pain can add to the functional disability associated with juvenile idiopathic arthritis. Resilience has relevance to all areas of paediatric psychology, and targeted attention to child, sibling, and parent strengths within the context of paediatric chronic pain and juvenile idiopathic arthritis in particular will augment the field on numerous levels...
November 2, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/29093239/paraneoplastic-arthritis-in-a-patient-with-non-hodgkin-s-lymphoma
#14
Guntur Darmawan, Indra Wijaya, Laniyati Hamijoyo, Trinugroho Heri Fadjari
Paraneoplastic syndromes are a group of disorders associated with benign or malignant tumors but not related to mass effect or invasion directly. Paraneoplastic syndromes may affect any organic system of the human body, such as endocrine, neurologic, dermatologic, hematologic, rheumatologic. Paraneoplastic rheumatic syndromes are not quite common, about 7-10% of paraneoplastic syndromes, and may mimic rheumatic diseases. We present an interesting case of paraneoplastic arthritis in a woman with non-Hodgkin's lymphoma...
July 2017: Acta Medica Indonesiana
https://www.readbyqxmd.com/read/29089217/-role-of-ultrasonography-in-rheumatoid-arthritis
#15
Saoussen Miladi, Kaouther Ben Abdelghani, Aliaa Fazaa, Ahmed Laatar, Leith Zakraoui
Ultrasound imaging may have an impact in management patients with rheumatoid arthritis. Through technological improvements, ultrasonography, has become an established imaging technique for the diagnosis and the follow up of this inflammatory chronic disease. In fact, ultrasounds, allow follow up during treatment by evaluating synovitis count and assessment of synovial vascularization by Power Doppler. Besides, erosions are found sooner and more frequently by ultrasonography than with conventional radiography...
October 28, 2017: La Presse Médicale
https://www.readbyqxmd.com/read/29088976/incidence-of-rheumatoid-arthritis-psoriatic-arthritis-and-polymyalgia-rheumatica-in-an-inland-area-of-central-italy-results-of-the-campo-rhe-study
#16
Antonia De Socio, Fabio Massimo Perrotta, Guido Maria Grasso, Ennio Lubrano
OBJECTIVE: The aim of the CAMPO-RHE study was to determine the incidence of rheumatoid arthritis (RA), psoriatic arthritis (PsA) and polymyalgia rheumatica (PMR) in patients attending a rheumatologic outpatient's clinic of a new institution in Campobasso, Italy. METHODS: Campobasso is a small town of approximately 50,000 inhabitants located in the inland territory of central Italy (Molise), and Public Health is managed from a single health authority. In Italy, all citizens are registered with a National Health System of General Practitioner (GP) Physicians...
November 3, 2017: Postgraduate Medicine
https://www.readbyqxmd.com/read/29083361/chondral-tissue-engineering-of-the-reumatoid-knee-with-collagen-matrix-autologous-chondrocytes-implant
#17
Massimiliano Leigheb, Michela Bosetti, Antonio De Consoli, Alessia Borroni, Mario Cannas, Federico Grassi
Articular cartilage repair is still a challenge. To date evidence is insufficient to support a treatment over the others. Inflammatory conditions in the joint hamper the application of tissue engineering during chronic joint diseases. Most of the Matrix Autologous Chondrocyte Implantation (MACI) cases reported in literature do not deal with rheumatoid knees and do not have a long clinical-histologic follow-up. We report about a 46-year old woman who suffered of a painful focal Outerbridge 4th degree chondral lesion in the medial femoral condyle of her left rheumatoid knee...
October 18, 2017: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/29083085/cdk7-inhibition-suppresses-rheumatoid-arthritis-inflammation-via-blockage-of-nf-%C3%AE%C2%BAb-activation-and-il-1%C3%AE-il-6-secretion
#18
Honghai Hong, Yingmin Zeng, Wenxuan Jian, Lei Li, Liying Lin, Yousheng Mo, Meiling Liu, Shuhuan Fang, Yong Xia
Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by joint swelling, joint tenderness and destruction of synovial joints, leading to severe disability. Anti-inflammatory drugs and disease-modifying anti-rheumatic drugs (DMARDs) may improve RA process. However, in most patients the treatment effect is still not satisfactory. Cyclin-dependent kinase 7 (CDK7) plays a well-established role in the regulation of the eukaryotic cell division cycle, and recent studies indicated that it exerted anti-inflammatory effect...
October 30, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29082659/two-year-persistence-of-golimumab-as-second-line-biologic-agent-in-rheumatoid-arthritis-as-compared-to-other-subcutaneous-tumor-necrosis-factor-inhibitors-real-life-data-from-the-lorhen-registry
#19
Ennio G Favalli, Luigi Sinigaglia, Andrea Becciolini, Vittorio Grosso, Roberto Gorla, Chiara Bazzani, Fabiola Atzeni, Pier C Sarzi Puttini, Enrico Fusaro, Raffaele Pellerito, Roberto Caporali
OBJECTIVES: To evaluate the 2-year retention rate of golimumab compared with etanercept and adalimumab as second-line biologic agent in rheumatoid arthritis (RA) patients who failed a previous tumor necrosis factor inhibitor (TNFi). METHODS: Data on RA patients treated with a second-line subcutaneous TNFi were extracted from a multicentric Italian cohort (the LORHEN registry). The analysis was limited to etanercept, adalimumab and golimumab in the period when all were available in Italy (since October 2010)...
October 30, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/29079928/calcification-of-coronary-arteries-in-early-rheumatoid-arthritis-prior-to-anti-rheumatic-therapy
#20
Helen V Udachkina, Diana S Novikova, Tatiana V Popkova, Irina G Kirillova, Evgenia I Markelova, Elena L Luchikhina, Galina V Lukina, Valentin E Sinitsyn, Dmitry E Karateev, Eugeniy L Nasonov
Accelerated coronary atherosclerosis is common in patients with rheumatoid arthritis (RA). To examine coronary artery calcification (CAC) frequency and severity, its correlation with traditional risk factors (TRF) of cardiovascular diseases (CVD) and inflammatory markers in patients with early RA prior to anti-rheumatic therapy. RA adult patients (ACR/EULAR criteria, 2010, duration ≤ 12 months, without prior administration of disease-modifying anti-rheumatic drugs, glucocorticoids) underwent 32-row scanning for CAC scoring...
October 27, 2017: Rheumatology International
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