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https://www.readbyqxmd.com/read/28815060/defective-expression-of-atg4d-abrogates-autophagy-and-promotes-growth-in-human-uterine-fibroids
#1
Abdeljabar El Andaloussi, Samar Habib, Gizem Soylemes, Archana Laknaur, Heba Elhusseini, Ayman Al-Hendy, Nahed Ismail
Uterine fibroids (UF) are the most common pelvic tumors in women of reproductive-age and they usually cause heavy menstrual bleeding, pain and infertility. Autophagy is a collection of processes that enables the cells to digest and recycle their cytoplasmic contents, such as toxic protein aggregates, defunct or disused organelles and invading microorganisms. Dysregulation in autophagy process were described in neoplasms; however, the contribution of autophagy to the pathogenesis of UF remains unknown. In this study, we demonstrate that autophagy is deregulated in human UF as evidenced by significant accumulation of autophagosome in human UF cells compared to normal myometrium cells...
2017: Cell Death Discovery
https://www.readbyqxmd.com/read/28765976/safety-and-efficacy-of-transcatheter-embolization-with-glubran-%C3%A2-2-cyanoacrylate-glue-for-acute-arterial-bleeding-a-single-center-experience-with-104-patients
#2
Gilles Abdulmalak, Olivier Chevallier, Nicolas Falvo, Lucy Di Marco, Aurélie Bertaut, Benjamin Moulin, Célina Abi-Khalil, Sophie Gehin, Pierre-Emmanuel Charles, Marianne Latournerie, Marco Midulla, Romaric Loffroy
PURPOSE: To assess the efficacy and the safety of Glubran(®)2 n-butyl cyanoacrylate metacryloxysulfolane (NBCA-MS) transcatheter arterial embolization (TAE) for acute arterial bleeding from varied anatomic sites and to evaluate the predictive factors associated with clinical success and 30-day mortality. METHODS: A retrospective review of consecutive patients who underwent emergent NBCA-MS Glubran(®)2 TAE between July 2014 and August 2016 was conducted. Variables including age, sex, underlying malignancy, cardiovascular comorbidities, coagulation data, systolic blood pressure, and number of red blood cells units (RBC) transfused before TAE were collected...
August 1, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28698416/-second-pneumothorax-in-an-ehlers-danlos-syndrome-patient-initially-treated-by-bullaectomy-twenty-two-years-ago
#3
Yamato Suzuki, Shinsaku Ueda, Satoshi Suzuki
A 2nd pneumothorax developed in a 40-years-old man after his 1st bilateral pneumothoraces were successfully treated by bullaectomies 22 years ago. For the past 10 years, he has suffered major complications such as repeated bleeding into the digestive tract due to vascular-type Ehlers-Danlos syndrome (vEDS). Although preoperative computed tomography demonstrated multiple bullae at the apex of the right lung, any abnormal findings suggesting tissue fragility was not found. At surgery, visceral pleura of the right lung had an almost normal appearance through a thoracoscope...
July 2017: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://www.readbyqxmd.com/read/28685802/hemorrhagic-meckel-s-diverticulum-interest-of-the-digestive-pertechnetate-scintigraphy
#4
Aida Mhiri, Ihsen Slim, Faouzi Ben Slimène
Meckel's diverticulum is the most prevalent congenital abnormality of the gastrointestinal tract. Clinical symptoms can result in pain, bleeding and perforation caused by peptic ulceration. Among all imaging modalities, Tc-99m pertechnetate scintigraphy is the most sensitive method for Meckel's diverticulum diagnosis, but only mentioned in a few publications. We report the case of a young child with rectal bleeding related hemorrhagic Meckel's diverticulum. Endoscopy and ultrasound were normal. The diagnosis was done by scintigraphy with technetium revealing an accumulation of radiotracer by mucous cells in ectopic gastric mucosa, which allows a detection of Meckel's diverticulum...
October 2016: La Tunisie Médicale
https://www.readbyqxmd.com/read/28682973/endoscopic-submucosal-tunnel-dissection-a-feasible-solution-for-large-superficial-rectal-neoplastic-lesions
#5
Jin-Lin Yang, Tao Gan, Lin-Lin Zhu, Yi-Ping Wang, Li Yang, Jun-Chao Wu
BACKGROUND: Although endoscopic submucosal tunnel dissection has been used for the resection of esophageal and stomach neoplastic lesions, there are still no reports about large superficial rectal neoplastic lesions. Compared with esophageal and stomach endoscopic submucosal dissection, the dissection of large superficial rectal neoplastic lesions is more difficult because of the flimsy bowel wall with abundant vasculature in the submucosal region, which results in poor endoscopic maneuverability and serious complications, such as bleeding and perforation...
August 2017: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/28638456/temozolomide-and-bevacizumab-induction-before-chemoradiotherapy-in-patients-with-bulky-glioblastoma-and-or-with-severe-neurological-impairment
#6
Ilan Darmon, Mony Chenda Morisse, Alexandre Coutte, Marie Blonski, Emilie Le Rhun, Luc Taillandier, Diana Bello Roufai, Christine Desenclos, Stéphanie Trudel, Jean-Christophe Faivre, Nicolas Blanchard, Bruno Chauffert, Mathieu Boone
Background. New approaches are needed for patients newly diagnosed with bulky glioblastoma (GB) and/or with severe neurological impairment that cannot benefit from first line temozolomide (TMZ)-based chemoradiotherapy. Bevacizumab (BEV), an antiangiogenic anti-VEGF-R monoclonal antibody, has a rapid impact on tumor-related brain edema in recurrent GB. The present study reports the feasibility and efficacy of an induction treatment with TMZ and BEV to alleviate the initial neurological impairment and/or to reduce the tumor volume before a delayed chemoradiotherapy...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28611935/gastrointestinal-amyloidosis-review-of-the-literature
#7
REVIEW
Kyle Rowe, Jon Pankow, Fredy Nehme, William Salyers
Gastrointestinal amyloidosis (GIA), a protein deposition disorder, represents a complex common pathway that encompasses multiple etiologies and presentations. It represents a significant diagnostic and treatment challenge. The disease results from the deposition of insoluble extracellular protein fragments that have been rendered resistant to digestion. GIA can be acquired or genetic, and most commonly results from chronic inflammatory disorders (AA amyloidosis), hematologic malignancy (AL amyloidosis), and end-stage renal disease (Beta-2 amyloidosis)...
May 8, 2017: Curēus
https://www.readbyqxmd.com/read/28598098/-improving-primary-culture-of-pulmonary-microvascular-endothelial-cells-of-rats
#8
Ling Jiang, Yuan-Dong Hu, Fei-Fei Xu, Ting-Hua Wang
OBJECTIVES: To improve the culturing method of pulmonary microvascular endothelial cells (PMEVCs) of SD rats. METHODS: The culturing processes in regard to obtaining peripheral lung tissue, attaching tissue block,preparing medium and subculturing were modified.These included an injection of heparin sodium before anesthesia, abdominal bleeding, opening of chest when breathing stopped, improvement of operational details, reduction of pollution by adding penicillin and streptomycin, discard of tissues after 48 h of primary culturing, remove of fibroblasts by a second digestion, and identification of cells using a fluorescence microscope for binding with lectin from BSI (FITC-BSI)...
September 2016: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://www.readbyqxmd.com/read/28589146/gastrointestinal-bleeding-is-an-independent-risk-factor-for-poor-prognosis-in-gist-patients
#9
Qi Liu, Yuji Li, Ming Dong, Fanmin Kong, Qi Dong
A retrospective analysis of prognosis of GIST was used to assess the prognostic effects of hemorrhage of digestive tract induced by mucosal invasion of primary gastrointestinal stromal tumors and related mechanisms. The conclusion is that GISTs with gastrointestinal hemorrhage are more likely to recur, which indicates poor prognosis. Therefore, gastrointestinal hemorrhage may be used as a significant indicator to assess the prognosis of patients.
2017: BioMed Research International
https://www.readbyqxmd.com/read/28567119/direct-oral-anticoagulants-and-digestive-bleeding-therapeutic-management-and-preventive-measures
#10
REVIEW
David Deutsch, Christian Boustière, Emile Ferrari, Pierre Albaladejo, Pierre-Emmanuel Morange, Robert Benamouzig
The use of direct oral anticoagulants (DOACs) was an important step forward in the management of atrial fibrillation and venous thromboembolism (VTE). The DOACs, anti-IIa for dabigatran and anti-Xa for rivaroxaban, apixaban and edoxaban, all have a rapid onset of action and a short half life. There is no need for routine hemostasis testing for treatment monitoring of a DOAC. Compared with vitamin K antagonists (VKAs), DOACs may increase the risk of gastrointestinal bleeding (relative risk 1.25). Withholding the DOAC treatment, evaluating the time of the last intake and estimating the patient's renal function are the first steps in the management of gastrointestinal bleeding...
June 2017: Therapeutic Advances in Gastroenterology
https://www.readbyqxmd.com/read/28560398/toxic-proteins-from-croton%C3%A2-tiglium-l-exert-a-proinflammatory-effect-by-inducing-release-of-proinflammatory-cytokines-and-activating-the-p38-mapk-signaling-pathway
#11
Liping Liu, Hongli Yu, Hao Wu, Xiaolin Yang, Yaozong Pan, Yeqing Chen, Kuilong Wang, Wei Wang, Wenying Zhang, Yangping Jin, Chengchao Zhang, Ai Jiang, Chunyan Xia
The aim of the present study was to determine the toxic targets of proteins from Croton tiglium L. and to investigate the potential mechanism of their toxicity. The toxic targets were determined by oral medication and intraperitoneal injection. The median lethal dose of oral medication in mice was calculated using Bliss software (2,752.8-3,407.5 mg/kg), and that of intraperitoneal injection was 195.8‑272.69 mg/kg. The results of histopathological examination demonstrated that the kidney was primarily impaired by intraperitoneal injection, with slight degeneration of renal tubular epithelial cells...
July 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28554655/hemorrhagic-angiodysplasia-of-the-digestive-tract-pathogenesis-diagnosis-and-management
#12
REVIEW
Aymeric Becq, Gabriel Rahmi, Guillaume Perrod, Christophe Cellier
Gastrointestinal angiodysplasia (GIA) is an acquired vascular superficial lesion, which presents typically as a bright red, irregular, round-shaped, slightly elevated lesion. GIAs are often seen in patients over 60 years of age and are mostly located in the colon (cecum and ascending).The cause and mechanisms of GIA have yet to be completely understood. Small-bowel GIAs are often diagnosed in the setting of obscure gastrointestinal bleeding (OGIB). In some cases, GIAs are associated with aortic stenosis, Von Willebrand's disease, chronic renal disease, and liver disease...
May 26, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28526929/analytical-management-of-patients-undergoing-oral-anticoagulant-therapy-could-have-a-strong-impact-on-clinical-outcomes-a-follow-up-study
#13
Vincenzo De Iuliis, Sebastiano Ursi, Gianfranco Vitullo, Irma Griffo, Antonio Marino, Marika Caruso, Francesco Cipollone, Sabrina Capodifoglio, Veronica Breda, Elena Toniato, Alfonso Pennelli, Pio Conti, Stefano Martinotti
INTRODUCTION: Oral anticoagulant therapy, such as vitamin K antagonists (VKAs), is prominent for the prevention of cerebral ischemic stroke or systemic embolism and all-cause mortality in patients with atrial fibrillation, venous thromboembolism, and mechanical or biological valve. VKA treatment requires monitoring of the international normalized ratio (INR) in order to maintain it in a therapeutic range, avoiding side effects, the main and most significant of which is bleeding. The aim of the present study was to evaluate the event rates of several clinical composite outcomes, such as bleeding, thromboembolic events, and all-cause death...
May 19, 2017: Cardiology and Therapy
https://www.readbyqxmd.com/read/28523318/hemobilia-through-aneurysm-of-the-right-hepatic-artery-22-months-after-laparoscopic-cholecystectomy-case-presentation
#14
Octavian Marius CreŢu, Radu Gheorghe Dan, Iulian Alexandru Ciprian Blidişel, LaurenŢiu Vasile Sima, Mihnea Munteanu, Ion Păun
Hemobilia is a rare cause of upper digestive bleeding, and it should be suspected when there are traumas of the liver area or surgical or exploratory interventions of the liver-bile-pancreas area in the patient's history. Iatrogenic bleeding occurs, most often, after transcutaneous bile punctures, laparoscopic cholecystectomies, cateterisms of the biliary ways. After such interventions, hemobilia may appear earlier, but also up to a few months later. We present a case of massive hemobilia occurring 22 months after a laparoscopic cholecystectomy...
2017: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/28511430/study-on-the-relation-between-colorectal-cancer-and-gall-bladder-disease
#15
Siddharth Gosavi, R Rama Mishra, Vsm Praveen Kumar
INTRODUCTION: Colorectal cancer is cancer of the large intestine, the lower part of digestive system which includes the sigmoid colon and rectum. AIM: To study the relation of incidence of colorectal cancer with previous gall bladder disease or post-cholecystectomy status, a relation between gall bladder disease and smoking in particular and the most common region of colon involved in colorectal cancer in gall bladder disease and non-gall bladder disease patients...
March 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28489846/-gastrointestinal-bleeding-and-acute-hepatic-failure-by-leptospirosis-an-entity-that-should-not-be-forgotten
#16
Carlos Alventosa Mateu, Lydia Plana Campos, Laura Larrey Ruíz, Raquel Acedo Mayordomo, Laura Sanchís Artero, Laura Peño Muñoz, Paola Concepción Núñez Martínez, Génesis Aurora Castillo López, Mercedes Latorre Sánchez, Juan José Urquijo Ponce, Moisés Diago Madrid, Javier Sempere García-Argüelles
Leptospirosis disease is caused by the spirochete Leptospira. It is a worldwide distribution zoonosis, with predominance in the tropics. In Spain, it is not frequent but some cases have been noticed especially in humid areas surrounded by rivers, lakes or ponds, such as Catalonia, Andalucia or the Valencian Community. It is transmitted by a variety of animals such as cows or rats, that are infected either by direct contact with these animals or their urine, or indirectly by consuming or being in contact with water contaminated by their urine...
January 2017: Revista de Gastroenterología del Perú: órgano Oficial de la Sociedad de Gastroenterología del Perú
https://www.readbyqxmd.com/read/28463675/surgical-treatment-of-splenic-artery-pseudoaneurysm-with-digestive-tract-communication-presentation-of-two-cases
#17
Mihai Adrian Eftimie, Oana Maria Stanciulea, Leonard David, Vasile Lungu, Simona Dima, Iulian Mosteanu, Luiza Tirca, Irinel Popescu
Splenopancreatectomy performed for pancreatic pseudo-cyst with splenic artery pseudo-aneurysm and communication with the digestive tract (stomach or colon) is a very rare indication and a small number of these procedures are described in literature. Managing peri-pancreatic pseudo-aneurysm is complex and can be challenging. Surgical treatment is of curative intent and can involve multiple visceral resections. Surgery can be performed in an emergency setting, if the patient presents cataclysmic bleeding, or in a planned manner if the pseudo-aneurysm is discovered incidentally or if the patient manages to overcome the initial bleeding...
March 2017: Chirurgia
https://www.readbyqxmd.com/read/28413675/primary-mesenteric-adenocarcinoma-covered-by-abscess-of-the-mesocolon-and-intestinal-obstruction-a-case-report
#18
Yun Luo, Memgchuan Ou, Yushun Zhang, Zhiming Fu, Chongshu Wang
Primary mesenteric adenocarcinoma (PMA) is a rare malignant disease. A case of PMA that was covered by an abscess of the mesocolon and intestinal obstruction is reported in the present study. As the onset site of PMA is often obscured or hidden, there may be no clinical symptoms in the early stage. At the advanced stage, the tumor size is large enough to induce intestinal obstruction, perforation, bleeding, volvulus and other clinical symptoms in the majority of patients. Computed tomography scans, ultrasound and other auxiliary examinations are not sufficiently accurate for diagnosing PMA with non-specific characteristics in the majority of cases, causing certain difficulties in the pre-operative diagnosis of PMA, which easily lead to misdiagnosis...
April 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28405330/middle-term-mortality-and-re-bleeding-after-initial-diverticular-bleeding-a-nationwide-study-of-365-mostly-elderly-french-patients
#19
Diane Lorenzo, Claire Gallois, Pierre Lahmek, Bruno Lesgourgues, Christine Champion, Claire Charpignon, Roger Faroux, Bruno Bour, André-Jean Remy, Chantal Naouri, Magali Picon, Eric Poncin, Gilles Macaigne, Jacques-Arnaud Seyrig, David Bernardini, Guy Bellaïche, Denis Grasset, Jean Henrion, Frédéric Heluwaert, René Piperaud, Gilbert Bordes, Francois Bourhis, Jean-Pierre Arpurt, Alexandre Pariente, Stéphane Nahon
BACKGROUND AND AIMS: The aim of this study was to determine the mortality and re-bleeding rates, and the risk factors involved, in a cohort of patients with previous diverticular bleeding (DB). METHODS: In 2007, data on 2462 patients with lower gastrointestinal (GI) bleeding were collected prospectively at several French hospitals. We studied the follow-up of patients with DB retrospectively. The following data were collected: age, mortality rates and re-bleeding rates, drug intake, surgery and comorbidities...
February 2017: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/28405321/the-expansion-of-endoscopic-submucosal-dissection-in-france-a-prospective-nationwide-survey
#20
Maximilien Barret, Vincent Lepilliez, Dimitri Coumaros, Stanislas Chaussade, Sarah Leblanc, Thierry Ponchon, Fabien Fumex, Edouard Chabrun, Paul Bauret, Christophe Cellier, Emmanuel Coron, Philippe Bichard, Philippe Bulois, Antoine Charachon, Gabriel Rahmi, Serge Bellon, Marc Lerhun, Jean-Pierre Arpurt, Stéphane Koch, Bertrand Napoleon, Eric Vaillant, Anouk Esch, Said Farhat, Francoise Robin, Nadira Kaddour, Frédéric Prat
INTRODUCTION: Early reports of endoscopic submucosal dissection (ESD) in Europe suggested high complication rates and disappointing outcomes compared to publications from Japan. Since 2008, we have been conducting a nationwide survey to monitor the outcomes and complications of ESD over time. MATERIAL AND METHODS: All consecutive ESD cases from 14 centers in France were prospectively included in the database. Demographic, procedural, outcome and follow-up data were recorded...
February 2017: United European Gastroenterology Journal
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