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https://www.readbyqxmd.com/read/29930805/detection-of-herv-k6-and-herv-k11-transpositions-in-the-human-genome
#1
Buket Cakmak Guner, Elif Karlik, Sevgi Marakli, Nermin Gozukirmizi
Mobile genetic elements classed as transposons comprise an estimated 45% of the human genome, and 8% of these elements are human endogenous retroviruses (HERVs). Endogenous retroviruses are retrotransposons, containing 5' and 3' long terminal repeat sequences and encoding envelope, group-specific antigen and DNA polymerase proteins. The aim of the present study was to analyse genome integration polymorphisms of HERV type K member 6 (HERV-K6) and HERV-K11 by using the retrotransposon based molecular marker technique, inter-retrotransposon amplified polymorphism (IRAP)...
July 2018: Biomedical Reports
https://www.readbyqxmd.com/read/29892962/retrotransposons-in-betula-nana-and-interspecific-relationships-in-the-betuloideae-based-on-inter-retrotransposon-amplified-polymorphism-irap-markers
#2
Neha Samir Roy, Sung-Il Lee, Kabwe Nkongolo, Nam-Soo Kim
The Betulaceae family comprises two subfamilies, Betuloideae and Corylaceae. The subfamily Betuloideae contains two genera, Alnus Mill. and Betula L. Twenty putative long terminal repeat (LTR) retrotransposons were mined from 171 scaffolds containing 5,208,995 bp of dwarf birch (Betula nana) genome sequences. Five retrotransposons were finally selected after filtering the retrotransposon canonical features and nucleotide similarities between left and right LTR sequences. Of the five retroelements, three elements were found to be Ty1/Copia retrotransposons; identity of the other two elements could not be ascertained due to sequence undetermined 'N' bases in the sequence database...
May 2018: Genes & Genomics
https://www.readbyqxmd.com/read/29802191/experimental-evolution-of-escherichia-coli-k-12-at-high-ph-and-rpos-induction
#3
Issam Hamdallah, Nadia Torok, Katarina M Bischof, Nadim Majdalani, Sriya Chadalavada, Nonto Mdluli, Kaitlin E Creamer, Michelle Clark, Chase Holdener, Preston J Basting, Susan Gottesman, Joan L Slonczewski
Experimental evolution of Escherichia coli K-12 W3110 by serial dilutions for 2,200 generations at high pH extended the range of sustained growth from pH 9.0 to pH 9.3. pH 9.3-adapted isolates showed mutations in DNA-binding regulators and envelope proteins. One population showed an IS1 knockout of phoB (positive regulator of the phosphate regulon). A phoB :: kanR knockout increased growth at high pH. phoB mutants are known to increase production of fermentation acids, which could enhance fitness at high pH...
May 25, 2018: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29666338/identification-of-ssr-and-retrotransposon-based-molecular-markers-linked-to-morphological-characters-in-oily-sunfl-ower-helianthus-annuus-l-under-natural-and-water-limited-states
#4
Soleimani Gezeljeh Ali, Reza Darvishzadeh, Asa Ebrahimi, Mohammad Reza Bihamta
Sunflower is an important source of edible oil. Drought is known as an important factor limiting the growth and productivity of field crops in most parts of the world. Agricultural biotechnology mainly aims at developing crops with higher tolerance to the challenging environmental conditions, such as drought. This study examined a number of morphological characters, along with relative water content (RWC) in 100 inbred sunflower lines. A 10 × 10 simple lattice design with two replications was employed to measure the mentioned parameters under natural and water-limited states during two successive years...
March 2018: Journal of Genetics
https://www.readbyqxmd.com/read/29409670/downstream-effects-of-a-large-reservoir-on-the-reproductive-activity-of-prochilodus-hartii-pisces-prochilodontidae
#5
Tiago Figueiredo Abdo, Lucas Marcon, Nilo Bazzoli
To analyze the effect of the Irapé reservoir on the reproduction of "curimba", Prochilodus hartii, a migratory species, 503 specimens were collected during the reproductive period from February 2012 to January 2013. Specimens were collected from two river sections within the Jequitinhonha River Basin: Site 1 - a section of the Itacambiruçu River, a tributary of the Jequitinhonha River upstream of the Irapé reservoir; and Site 2 - a section of the Jequitinhonha River immediately downstream from the Irapé dam...
March 2018: Animal Reproduction Science
https://www.readbyqxmd.com/read/29378555/the-clinical-course-and-pathophysiological-investigation-of-adolescent-gestational-diabetes-insipidus-a-case-report
#6
Tatsuya Kondo, Miwa Nakamura, Sayaka Kitano, Junji Kawashima, Takeshi Matsumura, Takashi Ohba, Munekage Yamaguchi, Hidetaka Katabuchi, Eiichi Araki
BACKGROUND: Gestational diabetes insipidus (GDI) is a rare endocrine complication during pregnancy that is associated with vasopressinase overproduction from the placenta. Although increased vasopressinase is associated with placental volume, the regulation of placental growth in the later stage of pregnancy is not well known. CASE PRESENTATION: A 16-year-old pregnant woman was urgently transferred to our hospital because of threatened premature labor when the Kumamoto earthquakes hit the area where she lived...
January 30, 2018: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/29373553/anti-inflammatory-and-antitumor-effects-of-hydroxytyrosol-but-not-oleuropein-on-experimental-glioma-in-vivo-a-putative-role-for-the-renin-angiotensin-system
#7
María Jesús Ramírez-Expósito, José Manuel Martínez-Martos
Functional roles of the angiotensin peptides of the renin-angiotensin system (RAS) cascade can be analyzed through their corresponding proteolytic regulatory enzymes aspartyl aminopeptidase (ASAP), aminopeptidase A (APA), aminopeptidase B (APB), aminopeptidase N (APN) and insulin-regulated aminopeptidase (IRAP). These enzyme activities generate active or inactive angiotensin peptides that alter the ratios between their bioactive forms, regulating several important processes such as the regulation of cardiovascular functions, body water regulation, normal memory consolidation and retrieval, but also cell growth, differentiation and apoptosis or the inflammatory response...
January 26, 2018: Biomedicines
https://www.readbyqxmd.com/read/29234880/reorganization-of-wheat-and-rye-genomes-in-octoploid-triticale-%C3%A3-triticosecale
#8
Anna Kalinka, Magdalena Achrem
The analysis of early generations of triticale showed numerous rearrangements of the genome. Complexed transformation included loss of chromosomes, t-heterochromatin content changes and the emergence of retrotransposons in new locations. This study investigated certain aspects of genomic transformations in the early generations (F5 and F8) of the primary octoploid triticale derived from the cross of hexaploid wheat with the diploid rye. Most of the plants tested were hypoploid; among eliminated chromosomes were rye chromosomes 4R and 5R and variable number of wheat chromosomes...
April 2018: Planta
https://www.readbyqxmd.com/read/29211968/men-and-women-differ-in-the-biochemical-composition-of-platelet-rich-plasma
#9
Grace Xiong, Nithya Lingampalli, Jayme C B Koltsov, Lawrence L Leung, Nidhi Bhutani, William H Robinson, Constance R Chu
BACKGROUND: Autologous platelet-rich plasma (PRP) is widely used for a variety of clinical applications. However, clinical outcome studies have not consistently shown positive effects. The composition of PRP differs based on many factors. An improved understanding of factors influencing the composition of PRP is important for the optimization of PRP use. HYPOTHESIS: Age and sex influence the PRP composition in healthy patients. STUDY DESIGN: Controlled laboratory study...
February 2018: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29208211/plasma-firocoxib-concentrations-after-intra-articular-injection-of-autologous-conditioned-serum-prepared-from-firocoxib-positive-horses
#10
K F Ortved, M B Goodale, C Ober, G A Maylin, L A Fortier
Orthobiologics such as autologous conditioned serum (ACS) are often used to treat joint disease in horses. Because ACS is generated from the horse's own blood, any medication administered at the time of preparation would likely be present in stored ACS, which could lead to an inadvertent positive drug test following intra-articular (IA) injection. The main objective of this study was to determine if ACS prepared from firocoxib positive horses could result in detectable plasma concentrations of the drug following IA injection...
December 2017: Veterinary Journal
https://www.readbyqxmd.com/read/29176619/stim1-promotes-migration-phagosomal-maturation-and-antigen-cross-presentation-in-dendritic-cells
#11
Paula Nunes-Hasler, Sophia Maschalidi, Carla Lippens, Cyril Castelbou, Samuel Bouvet, Daniele Guido, Flavien Bermont, Esen Y Bassoy, Nicolas Page, Doron Merkler, Stéphanie Hugues, Denis Martinvalet, Bénédicte Manoury, Nicolas Demaurex
Antigen cross-presentation by dendritic cells (DC) stimulates cytotoxic T cell activation to promote immunity to intracellular pathogens, viruses and cancer. Phagocytosed antigens generate potent T cell responses, but the signalling and trafficking pathways regulating their cross-presentation are unclear. Here, we show that ablation of the store-operated-Ca2+ -entry regulator STIM1 in mouse myeloid cells impairs cross-presentation and DC migration in vivo and in vitro. Stim1 ablation reduces Ca2+ signals, cross-presentation, and chemotaxis in mouse bone-marrow-derived DCs without altering cell differentiation, maturation or phagocytic capacity...
November 24, 2017: Nature Communications
https://www.readbyqxmd.com/read/29163319/functional-relations-modulate-the-responsiveness-to-affordances-despite-the-impact-of-conflicting-stimulus-response-mappings
#12
Roberta Vastano, Martin Finn, Dermot Barnes-Holmes
The study investigated how conflicting stimulus-response mappings influenced affordance processing given a manipulation of the functional relations. Participants performed a task involving consistent-inconsistent stimulus-response mappings: Implicit Relational Assessment Procedure (IRAP). They were instructed to confirm or to deny a relation between words and tool-objects (consistent blocks) or to provide non-conventional responses (inconsistent blocks). The relations between stimuli could functionally match (e...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/29162483/altered-expression-of-cxcr1-il-8r-in-macrophages-utilizing-cell-surface-tnfr1-and-il-1-receptor-during-staphylococcus-aureus-infection
#13
Biswadev Bishayi, Rana Adhikary, Sahin Sultana, Rajen Dey, Ajeya Nandi
Currently, very few studies are available on the expression of CXCR1 in mouse macrophages having both intact TNFR1 and IL-1R or their deficiency in relation to acute S. aureus infection. Peritoneal macrophages from mice neutralized singly for TNFR1or IL-1R, or for both TNFR1 and IL-1R were infected with S. aureus in vitro and their ability to secrete cytokines and reactive oxygen species (ROS) were determined. It was observed that the release of TNF-α and IL-1β in response to S. aureus infection was decreased in macrophages when both TNFR1 and IL-1R were neutralized...
December 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29124522/retraction-note-to-potential-start-codon-targeted-scot-and-interretrotransposon-amplified-polymorphism-irap-markers-for-evaluation-of-genetic-diversity-and-conservation-of-wild-pistacia-species-population
#14
Karim Sorkheh, Nazanin Amirbakhtiar, Sezai Ercisli
"This article has been retracted by the Publisher in agreement with the Editor-in-Chief, because it contains portions of writings on the same topic already published and without sufficient attribution to these earlier works being given. The principal authors of the paper acknowledged that text from background sources was mistakenly used in this article without proper reference to the original source. Upon investigation carried out according to the Committee on Publication Ethics guidelines, it has been found that the authors have duplicated or rephrased parts from other articles of which the main sources...
December 2017: Biochemical Genetics
https://www.readbyqxmd.com/read/29097868/role-of-endoscopic-ultrasound-in-idiopathic-pancreatitis
#15
REVIEW
Piyush Somani, Tagore Sunkara, Malay Sharma
Recurrent acute pancreatitis (RAP) is defined based on the occurrence of two or more episodes of acute pancreatitis. The initial evaluation fails to detect the cause of RAP in 10%-30% of patients, whose condition is classified as idiopathic RAP (IRAP). Idiopathic acute pancreatitis (IAP) is a diagnostic challenge for gastroenterologists. In view of associated morbidity and mortality, it is important to determine the aetiology of pancreatitis to provide early treatment and prevent recurrence. Endoscopic ultrasound (EUS) is an investigation of choice for imaging of pancreas and biliary tract...
October 14, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29061665/dksa-and-ppgpp-regulate-the-%C3%AF-s-stress-response-by-activating-promoters-for-the-small-rna-dsra-and-the-anti-adapter-protein-irap
#16
Mary E Girard, Saumya Gopalkrishnan, Elicia D Grace, Jennifer A Halliday, Richard L Gourse, Christophe Herman
σS is an alternative sigma factor, encoded by the rpoS gene, that redirects cellular transcription to a large family of genes in response to stressful environmental signals. This so-called σS general stress response is necessary for survival in many bacterial species and is controlled by a complex, multifactorial pathway that regulates σS levels transcriptionally, translationally, and post-translationally in Escherichia coli It was shown previously that the transcription factor DksA and its cofactor ppGpp are among the many factors governing σS synthesis, thus playing an important role in activation of the σS stress response...
October 23, 2017: Journal of Bacteriology
https://www.readbyqxmd.com/read/28985964/the-hemoglobin-derived-peptide-lvv-hemorphin-7-evokes-behavioral-effects-mediated-by-oxytocin-receptors
#17
Kellen Rosa da Cruz, Larissa Córdova Turones, Gabriel Camargo-Silva, Karina Pereira Gomes, Michelle Mendanha Mendonça, Pablinny Galdino, Christielly Rodrigues-Silva, Robson Augusto Souza Santos, Elson Alves Costa, Paulo Cesar Ghedini, Danielle Ianzer, Carlos Henrique Xavier
LVV-hemorphin-7 (LVV-h7) is bioactive peptide resulting from degradation of hemoglobin β-globin chain. LVV-h7 is a specific agonist of angiotensin IV receptor. This receptor belongs to the class of insulin-regulated aminopeptidases (IRAP), which displays oxytocinase activity. Herein, our aims were to assess whether: i) LVV-h7 modifies centrally organized behavior and cardiovascular responses to stress and ii) mechanisms underlying LVV-h7 effects involve activation of oxytocin (OT) receptors, probably as result of reduction of IRAP proteolytic activity upon OT...
September 28, 2017: Neuropeptides
https://www.readbyqxmd.com/read/28894091/expansion-of-cytotoxic-natural-killer-cells-using-irradiated-autologous-peripheral-blood-mononuclear-cells-and-anti-cd16-antibody
#18
Hong-Rae Lee, Cheol-Hun Son, Eun-Kyoung Koh, Jae-Ho Bae, Chi-Dug Kang, Kwangmo Yang, You-Soo Park
Natural killer (NK) cells are considered a promising strategy for cancer treatment. Various methods for large-scale NK cell expansion have been developed, but they should guarantee that no viable cells are mixed with the expanded NK cells because most methods involve cancer cells or genetically modified cells as feeder cells. We used an anti-CD16 monoclonal antibody (mAb) and irradiated autologous peripheral blood mononuclear cells (PBMCs) (IrAPs) to provide a suitable environment (activating receptor-ligand interactions) for the NK cell expansion...
September 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28878503/assessment-of-genetic-diversity-and-population-structure-of-an-endemic-moroccan-tree-argania-spinosa-l-based-in-irap-and-issr-markers-and-implications-for-conservation
#19
Ouafae Pakhrou, Leila Medraoui, Chaimaa Yatrib, Mohammed Alami, Abdelkarim Filali-Maltouf, Bouchra Belkadi
Argan Tree is well known for its precious oil extracted from its seeds particularly used for the nutritional and cosmetic benefits. Because of the high international demand, the argan tree suffers from overexploitation and its cultivation is rare. Thus, the assessment of the genetic variation of this endemic tree is critically important for designing conservation strategies. In the present study and for the first time, genetic diversity of the global natural distribution of argan tree (Argania spinosa L.) in Morocco was assessed...
July 2017: Physiology and Molecular Biology of Plants: An International Journal of Functional Plant Biology
https://www.readbyqxmd.com/read/28729554/comparison-of-traditional-and-new-generation-dna-markers-declares-high-genetic-diversity-and-differentiated-population-structure-of-wild-almond-species
#20
Karim Sorkheh, Mehrana Koohi Dehkordi, Sezai Ercisli, Attila Hegedus, Júlia Halász
Wild almond species as sources of genetic variation may have crucial importance in breeding. A total of 389 accessions of 18 species have been analysed using inter-retrotransposon amplified polymorphism (IRAP), retrotransposon-microsatellite amplified polymorphism (REMAP), sequence-specific amplification polymorphism (S-SAP), amplified fragment length polymorphism (AFLP), inter simple sequence repeat (ISSR) and simple sequence repeats (SSR). Retrotransposon markers indicated the presence and movement of some Ty3-gypsy and Ty1-copia-elements in almond genome...
July 20, 2017: Scientific Reports
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