Xinzhou Yan, Yuqi Xia, Bojun Li, Zehua Ye, Lei Li, Tianhui Yuan, Baofeng Song, Weimin Yu, Ting Rao, Jinzhuo Ning, Fangyou Lin, Shuqin Mei, Zhiguo Mao, Xiangjun Zhou, Wei Li, Fan Cheng
Epigenetic regulation is reported to play a significant role in the pathogenesis of various kidney diseases, including renal cell carcinoma, acute kidney injury, renal fibrosis, diabetic nephropathy, and lupus nephritis. However, the role of epigenetic regulation in calcium oxalate (CaOx) crystal deposition-induced kidney injury remains unclear. Our study demonstrated that the upregulation of enhancer of zeste homolog 2 (EZH2)-mediated ferroptosis facilitates CaOx-induced kidney injury. CaOx crystal deposition promoted ferroptosis in vivo and in vitro...
January 2, 2024: Journal of Translational Medicine