Filipe Fideles Duarte-Andrade, Thais Dos Santos Fontes Pereira, Jéssica Gardone Vitório, Marina Gonçalves Diniz, Larissa Stefhanne Damasceno Amorim, Arkadiusz Nawrocki, Liza Figueiredo Felicori, Luiz De Marco, Carolina Cavaliéri Gomes, Martin R Larsen, Marcella Nunes Melo-Braga, Ricardo Santiago Gomez
BACKGROUND: Fibrous dysplasia (FD) and cemento-ossifying fibroma (COF) are the most common gnathic fibro-osseous lesions. These diseases exhibit remarkable overlap of several clinicopathological aspects, and differential diagnosis depends on the combination of histopathological, radiographic, and clinical aspects. Their molecular landscape remains poorly characterized, and herein, we assessed their proteomic and phosphoproteomic profiles. METHODS: The quantitative differences in protein profile of FD and COF were assessed by proteomic and phosphoproteomic analyses of formalin-fixed paraffin-embedded tissue samples...
February 1, 2022: Journal of Oral Pathology & Medicine