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https://www.readbyqxmd.com/read/29411208/stool-pcr-for-gastrointestinal-pathogens-in-patients-with-and-without-immune-mediated-intestinal-diseases
#1
Yael R Nobel, Jordan Axelrad, Suzanne K Lewis, Susan Whittier, Garrett Lawlor, Simon Lichtiger, Peter H R Green, Benjamin Lebwohl
BACKGROUND: Patients with celiac disease and inflammatory bowel disease, two immune-mediated luminal conditions, have higher rates of certain infections than healthy counterparts. The prevalence of many gastrointestinal infections in these patients, however, is unknown. AIMS: Using a novel clinical stool pathogen PCR test, we investigated the hypothesis that patients with celiac disease/inflammatory bowel disease had different distributions of diarrheal pathogens than other patients...
February 6, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29401338/a-tertiary-care-center-s-experience-with-novel-molecular-meningitis-encephalitis-diagnostics-and-implementation-with-antimicrobial-stewardship
#2
David Chang, Jason F Okulicz, Lindsey E Nielsen, Brian K White
Background: Novel molecular techniques, such as the Biofire FilmArray Meningitis/Encephalitis (ME) panel, are increasingly used to improve pathogen detection and time to detection (TtD). The Brooke Army Medical Center antibiotic stewardship program evaluated the impact of the ME panel on empiric antimicrobial usage. Methods: Negative ME panels were analyzed for days of therapy (DOT). The ME panel became available at Brooke Army Medical Center on January 1, 2016 and a retrospective chart review was performed on all hospitalized patients tested by ME panel through April 30, 2016...
January 1, 2018: Military Medicine
https://www.readbyqxmd.com/read/29394385/use-of-a-multiplex-dna-extraction-pcr-in-the-identification-of-pathogens-in-travelers-diarrhea
#3
Bradley A Connor, Marina Rogova, Olga Whyte
Background: Diarrhea is one of the most common ailments afflicting travelers with attack rates of 30-40% for medium to high-risk destinations. As travelers' diarrhea (TD) is syndromic and caused by a wide range of pathogens, including bacteria, parasites and viruses, multiplex deoxyribonucleic acid (DNA) extraction polymerase chain reaction (PCR) technology can be useful for determining the etiology of TD pathogens. Objective: The goal of this retrospective study was to produce clinically relevant and useful data on gastrointestinal illness related to travel identified by culture-independent methods of diagnosis-use of the multiplex DNA extraction PCR platform (BioFire FilmArray GI Panel) and to describe the use of this technology in detection of enteric pathogens...
January 1, 2018: Journal of Travel Medicine
https://www.readbyqxmd.com/read/29332209/the-rapid-diagnosis-of-viral-respiratory-tract-infections-and-its-impact-on-antimicrobial-stewardship-programs
#4
Şiran Keske, Önder Ergönül, Faik Tutucu, Doruk Karaaslan, Erhan Palaoğlu, Füsun Can
We aimed to describe the potential benefit of new rapid molecular respiratory tests (MRT) in decreasing inappropriate antibiotic use among the inpatients presenting with influenza-like illness (ILI). We included patients from inpatient and outpatient departments who had ILI and performed MRT between 1 January 2015 and 31 December 2016 in a 265-bed private hospital in Istanbul. At the end of 2015, we implemented antimicrobial stewardship including systematic use of MRT. Then, we compared our observations between the year 2015 and the year 2016...
January 13, 2018: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/29316801/economic-analysis-of-rapid-multiplex-polymerase-chain-reaction-testing-for-meningitis-encephalitis-in-pediatric-patients
#5
Steve Duff, Rodrigo Hasbun, Christine C Ginocchio, Joan-Miquel Balada-Llasat, Louise Zimmer, Samuel A Bozzette
AIM: We assessed the possible economic impact of a rapid test in pediatric patients with suspected community-acquired meningitis/encephalitis. MATERIALS & METHODS: Modeling simulated diagnosis, clinical decisions, resource use/costs of standard of care (SOC) and two cerebrospinal fluid testing strategies using FilmArray® (FA), a US FDA-cleared system that provides results in approximately 1 h. RESULTS: Pathogens detected by FA caused approximately 75% of cases, 97% of which would be accurately diagnosed with FA...
January 10, 2018: Future Microbiology
https://www.readbyqxmd.com/read/29279453/evaluation-of-the-filmarray-blood-culture-identification-panel-in-detecting-pathogenic-microorganisms-from-positive-blood-cultures-the-first-clinical-report-in-japan
#6
Kyoichi Saito, Shiro Endo, Makoto Katsumi, Chiyuki Ishizawa, Yuko Fujikawa, Shinya Inomata, Masahiro Toyokawa, Mitsuo Kaku
  The FilmArray (FA) is a multiplex polymerase chain reaction (PCR)-based desktop microbial detection system. The Blood Culture Identification (BCID) panel is an adaptable panel for the FA, which diagnoses sepsis or/and systemic infections by detecting 14 bacterial species, 4 bacterial genera, 1 bacterial family, 5 yeast species, and 3 antimicrobial resistance genes (mecA, KPC, and vanA/B) from positive blood cultures within 1 hour. We retrospectively evaluated the FA-BCID panel, using 54 positive blood cultures, from which 57 bacteria and 3 yeasts were identified through matrix-assisted laser desorption/ionization-time of flight mass spectrometry (MALDI-TOF MS) analysis...
December 26, 2017: Japanese Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29259822/efficacy-of-a-bovine-colostrum-and-egg-based-intervention-in-acute-childhood-diarrhoea-in-guatemala-a-randomised-double-blind-placebo-controlled-trial
#7
James T Gaensbauer, Mario A Melgar, Diva M Calvimontes, Molly M Lamb, Edwin J Asturias, Ingrid L Contreras-Roldan, Samuel R Dominguez, Christine C Robinson, Stephen Berman
Background: Treatments for paediatric diarrhoeal disease are limited. We assessed the impact of a bovine colostrum and egg-based treatment designed to reduce diarrhoea duration through non-specific and pathogen-directed mechanisms in children. Methods: Randomised, double-blind, placebo-controlled trial of PTM202, derived from bovine colostrum and hyperimmune hen's egg on the duration of acute diarrhoeal disease in Guatemalan children. PTM202 contains specific immunoglobulins that target rotavirus, enterotoxigenic Escherichia coli, Shiga toxin-producing E...
2017: BMJ Global Health
https://www.readbyqxmd.com/read/29237784/low-yield-of-filmarray-gi-panel-in-hospitalized-patients-with-diarrhea-an-opportunity-for-diagnostic-stewardship-intervention
#8
Matthew M Hitchcock, Carlos A Gomez, Niaz Banaei
FilmArray GI Panel (BioFire Diagnostics, Salt Lake City, UT) is a multiplex, on-demand, sample-to-answer, real-time PCR assay for the syndromic diagnosis of infectious gastroenteritis that has become widely adopted and, in some instances, replaced conventional stool culture and parasite exams. Conventional testing has historically been restricted among hospitalized patients due to low diagnostic yield, but it is not known whether use of the FilmArray GI Panel should be circumscribed. Cary-Blair stool samples submitted for FilmArray GI Panel in adult patients admitted to an academic hospital from August 2015 to January 2017 were included in this study...
December 13, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29212701/multicenter-evaluation-of-the-eplex%C3%A2-respiratory-pathogen-panel-for-the-detection-of-viral-and-bacterial-respiratory-tract-pathogens-in-nasopharyngeal-swabs
#9
N Esther Babady, Matthew R England, Kristen L Jurcic Smith, Taojun He, Dona Saumya Wijetunge, Yi-Wei Tang, Robin R Chamberland, Marilyn Menegus, Ella M Swierkosz, Robert C Jerris, Wallace Greene
Background: The performance of the new ePlex® Respiratory Pathogen (RP) Panel (GenMark Diagnostics) for the simultaneous detection of 19 viruses (influenza A, influenza A H1, influenza A 2009 H1, influenza A H3, influenza B, adenovirus, coronaviruses [HKU1, OC43, NL63, 229E], human rhinovirus/enterovirus, human metapneumovirus, parainfluenza viruses 1, 2, 3 and 4, respiratory syncytial virus (RSV) [RSVA and RSV B]) and two bacteria (Mycoplasma pneumoniae and Chlamydia pneumoniae) was evaluated.Methods: Prospectively and retrospectively collected nasopharyngeal swab (NPS) specimens (n =2,908) were evaluated using the ePlex RP Panel with the bioMérieux/BioFire FilmArray® Respiratory Panel (BF RP) as the comparator method...
December 6, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29208560/multiplex-pcr-system-for-the-rapid-diagnosis-of-respiratory-virus-infection-a-systematic-review-and-meta-analysis
#10
REVIEW
Huai-Shiuan Huang, Chi-Lin Tsai, Jeffrey Chang, Tzu-Chun Hsu, Samuel Lin, Chien-Chang Lee
OBJECTIVES: We aim to provide a summary of evidence for the diagnostic accuracies of three multiplex PCR systems (mPCRs): BioFire Filmarray RP (Filmarray), Nanosphere Verigene RV+ test (Verigene) and Hologic Gen-Probe Prodesse assays on the detection of viral respiratory infections. METHODS: A comprehensive search up to July 1st, 2017 was conducted on Medline and Embase for studies that utilized Filmarray, Verigene and Prodesse for diagnosis of viral respiratory infections...
December 2, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29099868/evaluation-of-a-multiplex-panel-for-the-diagnosis-of-acute-infectious-diarrhea-in-immunocompromised-hematologic-patients
#11
Izaskun Alejo-Cancho, Francesc Fernández Avilés, Alicia Capón, Cristina Rodríguez, Josep Barrachina, Pilar Salvador, Mª Eugenia Valls, Miriam J Álvarez-Martínez, Yuliya Zboromyrska, Jordi Vila, Mª Ángeles Marcos
INTRODUCTION: Diarrhea is a frequent complication in hematologic patients, being an infectious cause frequently suspected. Rapid and accurate detection of gastrointestinal pathogens is vital in immunocompromised hosts. The aim of this study was to compare routine diagnostic methods versus a multiplex polymerase chain reaction (PCR) assay for the diagnosis of infectious diarrhea in immunocompromised hematologic patients. MATERIAL AND METHODS: We conducted a prospective observational study from March 2015 to January 2016 to compare conventional methods for the diagnosis of infectious diarrhea with FIlmArray GI Panel (BioFire-bioMérieux, France)...
2017: PloS One
https://www.readbyqxmd.com/read/29096535/impact-of-early-multiplex-filmarray-respiratory-pathogen-panel-rpp-assay-on-hospital-length-of-stay-in-pediatric-patients-younger-than-3-months-admitted-for-fever-or-sepsis-workup
#12
Cory McFall, Hossein Salimnia, Paul Lephart, Ronald Thomas, Eric McGrath
No abstract text is available yet for this article.
November 1, 2017: Clinical Pediatrics
https://www.readbyqxmd.com/read/29093106/a-gastrointestinal-pcr-panel-improves-clinical-management-and-lowers-healthcare-costs
#13
Stacy G Beal, Elizabeth E Tremblay, Steven Toffel, Lymaries Velez, Kenneth H Rand
Conventional methods for identification of gastrointestinal pathogens are time consuming, expensive, and have limited sensitivity. The aim of this study was to determine the clinical impact of a comprehensive molecular test, the BioFire FilmArray® Gastrointestinal (GI) Panel which tests for many of the most common agents of infectious diarrhea in approximately one hour. Patients with stool cultures submitted were tested on the GI Panel (n=241) and were compared with control patients (n=594) from the year prior...
November 1, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29092659/cost-justification-of-the-biofire-filmarray-meningitis-encephalitis-panel-versus-standard-of-care-for-diagnosing-meningitis-in-a-community-hospital
#14
Dana K Soucek, Lisa E Dumkow, Kali M VanLangen, Andrew P Jameson
BACKGROUND: Cerebrospinal fluid (CSF) Gram stain and culture along with CSF viral polymerase chain reaction (PCR) are the current standard of care (SOC) to diagnose meningitis. Unfortunately, these tests take up to 72 hours to provide results and are not always sensitive to detect a pathogen. BioFire FilmArray (FA) meningitis/encephalitis (ME) panel uses PCR to provide quick, accurate identification of the causative organism. For community hospitals, the cost of this technology may be prohibitive...
January 1, 2017: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/29075617/distinctive-gut-microbiota-is-associated-with-diarrheagenic-escherichia-coli-infections-in-chilean-children
#15
Pablo Gallardo, Mariana Izquierdo, Roberto M Vidal, Nayaret Chamorro-Veloso, Ramon Rosselló-Móra, Miguel O'Ryan, Mauricio J Farfán
Background: Diarrheagenic Escherichia coli (DEC) strains are a major cause of diarrhea in children under 5 years of age worldwide. DEC pathogenicity relies on the interaction of bacteria with environmental factors, including the host's resident gut microbiota. Previous reports have shown changes in the gut microbiota's composition during episodes of diarrhea, which may increase the pathogenicity of DEC strains. More intense and detailed identification of microbiota strains specifically associated with DEC infections and disease is needed to pinpoint their role in DEC pathogenicity...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/29071818/evaluation-of-allplex-respiratory-panel-1-2-3-multiplex-real-time-pcr-assays-for-the-detection-of-respiratory-viruses-with-influenza-a-virus-subtyping
#16
Jaehyeon Lee, Hye Soo Lee, Yong Gon Cho, Sam Im Choi, Dal Sik Kim
The Allplex Respiratory Panel 1/2/3 (All16) is a multiplex PCR assay for detecting 16 respiratory viruses with influenza A virus (FluA) subtyping, and the first clinical assay based on multiple detection temperatures. We compared the results between All16 and Anyplex II RV16 (Any16) in 426 clinical samples. Samples showing discrepancies between the two tests were further tested using monoplex PCR. FluA subtyping based on the hemagglutinin type results of All16, which yielded H1, H3, and non-H1/H3, was compared with the results of the BioFire FilmArray respiratory panel...
January 2018: Annals of Laboratory Medicine
https://www.readbyqxmd.com/read/29018819/the-clinical-significance-of-filmarray-respiratory-panel-in-diagnosing-community-acquired-pneumonia
#17
Huanzhu Chen, Huilan Weng, Meirui Lin, Ping He, Yazhen Li, Qingdong Xie, Changwen Ke, Xiaoyang Jiao
AIM: FilmArray Respiratory Panel (FilmArray RP) test is an emerging diagnostic method in fast detecting multiple respiratory pathogens; the methodology and clinical significance of FilmArray RP in community-acquired pneumonia (CAP) diagnosis were evaluated in this study. METHODS: Specimens from 74 patients with CAP were analyzed and compared using FilmArray RP, traditional multiple PCR assay, bacterial (or fungal) culture, and serological detection. RESULTS: FilmArray RP and multiplex PCR showed 100% coincidence rate in detecting coronaviruses 229E, OC43, HKU1, and NL63, human metapneumovirus, influenza A and B, and parainfluenza viruses (PIV1, PIV2, and PIV4)...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29017451/multiplex-pcr-point-of-care-testing-versus-routine-laboratory-based-testing-in-the-treatment-of-adults-with-respiratory-tract-infections-a-quasi-randomised-study-assessing-impact-on-length-of-stay-and-antimicrobial-use
#18
Denise Andrews, Yumela Chetty, Ben S Cooper, Manjinder Virk, Stephen K Glass, Andrew Letters, Philip A Kelly, Malur Sudhanva, Dakshika Jeyaratnam
BACKGROUND: Laboratory-based respiratory pathogen (RP) results are often available too late to influence clinical decisions such as hospitalisation or antibiotic treatment due to time delay in transport of specimens and testing schedules. Ward-based i.e. point of care (POC) testing providing rapid results may alter the clinical management pathway. METHODS: FilmArray® RP polymerase chain reaction (PCR) systems were placed in three in-patient and out-patient medical areas...
October 10, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28947901/evaluation-of-nxtag-respiratory-pathogen-panel-and-comparison-with-xtag-respiratory-viral-panel-fast-v2-and-film-array-respiratory-panel-for-detecting-respiratory-pathogens-in-nasopharyngeal-aspirates-and-swine-avian-origin-influenza-a-subtypes-in-culture-isolates
#19
K H Chan, K K W To, P T W Li, T L Wong, R Zhang, K K H Chik, G Chan, C C Y Yip, H L Chen, I F N Hung, J F W Chan, K Y Yuen
This study evaluated a new multiplex kit, Luminex NxTAG Respiratory Pathogen Panel, for respiratory pathogens and compared it with xTAG RVP Fast v2 and FilmArray Respiratory Panel using nasopharyngeal aspirate specimens and culture isolates of different swine/avian-origin influenza A subtypes (H2N2, H5N1, H7N9, H5N6, and H9N2). NxTAG RPP gave sensitivity of 95.2%, specificity of 99.6%, PPV of 93.5%, and NPV of 99.7%. NxTAG RPP, xTAG RVP, and FilmArray RP had highly concordant performance among each other for the detection of respiratory pathogens...
2017: Advances in Virology
https://www.readbyqxmd.com/read/28931467/clinical-features-and-molecular-epidemiology-of-diarrheagenic-escherichia-coli-pathotypes-identified-by-fecal-gastrointestinal-multiplex-nucleic-acid-amplification-in-patients-with-cancer-and-diarrhea
#20
Andrew W Chao, Micah Bhatti, Herbert L DuPont, James P Nataro, Lily G Carlin, Pablo C Okhuysen
Diarrheagenic Escherichia coli (DEC) pathotypes with differing epidemiology and clinical features, are known causes of disease with worldwide occurrence. At a major cancer center in the U.S., we studied patients with cancer and diarrhea for whom a GI Biofire FilmArray multiplex GI panel (BFM) was performed. An enteropathogen was identified in 382 of 2017 (19%) samples distributed across 311 patients. Of these, 60/311(19%) were positive for DEC. Patients receiving hematopoietic stem cell transplants (HSCT) 29/60 (48%) or with a hematologic malignancy 17/60 (28%) accounted for the majority of DEC cases...
August 12, 2017: Diagnostic Microbiology and Infectious Disease
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