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https://www.readbyqxmd.com/read/28630187/cumulative-effect-of-an-antimicrobial-stewardship-and-rapid-diagnostic-testing-bundle-on-early-streamlining-of-antimicrobial-therapy-in-gram-negative-bloodstream-infections
#1
P B Bookstaver, E B Nimmich, T J Smith, J A Justo, J Kohn, K L Hammer, C Troficanto, H A Albrecht, M N Al-Hasan
OBJECTIVES: The use of rapid diagnostic tests (RDT) enhances antimicrobial stewardship programs (ASP) interventions in optimization of antimicrobial therapy. This quasi-experimental cohort study evaluates the combined impact of an ASP/RDT bundle on appropriateness of empirical antimicrobial therapy (EAT) and time to de-escalation of broad-spectrum agents (BSAA) in gram-negative bloodstream infections (GNBSI). METHODS: ASP/RDT bundle consisted of a system-wide GNBSI treatment guidelines, prospective stewardship monitoring, and sequential introduction of two RDTs, Matrix Assisted Laser Desorption Ionization Time-of-Flight (MALDI-TOF) and FilmArray® Blood Culture Identification (BCID) panel...
June 19, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28625839/surveillance-of-upper-respiratory-infections-using-a-new-multiplex-pcr-assay-compared-to-conventional-methods-during-the-influenza-season-in-taiwan
#2
Shu-Chun Chiu, Yung-Cheng Lin, Hsiao-Chi Wang, Jen-Jen Hsu, Ting-Kai Yeh, Hsin-Fu Liu, Jih-Hui Lin
OBJECTIVES: To improve diagnosis as part of laboratory surveillance in Taiwan, influenza-like illness (ILI) surveillance was conducted using a new multiplex PCR assay (FilmArray) and the results compared to those of conventional methods The study was performed during the winter months. METHODS: Throat swabs from patients with an ILI presenting to physicians in sentinel practices were collected during the 2016-2017 influenza season. RESULTS: A total of 52 samples tested positive by FilmArray Respiratory Panel...
June 15, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28619124/multiplex-tests-to-identify-gastrointestinal-bacteria-viruses-and-parasites-in-people-with-suspected-infectious-gastroenteritis-a-systematic-review-and-economic-analysis
#3
Karoline Freeman, Hema Mistry, Alexander Tsertsvadze, Pam Royle, Noel McCarthy, Sian Taylor-Phillips, Rohini Manuel, James Mason
BACKGROUND: Gastroenteritis is a common, transient disorder usually caused by infection and characterised by the acute onset of diarrhoea. Multiplex gastrointestinal pathogen panel (GPP) tests simultaneously identify common bacterial, viral and parasitic pathogens using molecular testing. By providing test results more rapidly than conventional testing methods, GPP tests might positively influence the treatment and management of patients presenting in hospital or in the community. OBJECTIVE: To systematically review the evidence for GPP tests [xTAG(®) (Luminex, Toronto, ON, Canada), FilmArray (BioFire Diagnostics, Salt Lake City, UT, USA) and Faecal Pathogens B (AusDiagnostics, Beaconsfield, NSW, Australia)] and to develop a de novo economic model to compare the cost-effectiveness of GPP tests with conventional testing in England and Wales...
April 2017: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/28600949/effect-of-genomic-drift-of-influenza-pcr-tests
#4
Kathleen A Stellrecht, Seela M Nattanmai, Jumshan Butt, Vincente P Maceira, Alvin A Espino, Allan J Castro, Allen Landes, Nicolas Dresser, Shafiq A Butt
BACKGROUND: Nucleic acid amplification assays have become the method of choice for influenza (Flu) testing due to superior accuracy and faster turnaround time. Although assays are designed to detect highly conserved genomic targets, mutations can influence test sensitivity. Most of the circulating viruses in the United States during the 2014-2015 season were associated with significant genetic drift; however, the effect on testing was unknown. OBJECTIVES AND STUDY DESIGN: We compared the performance of Prodesse ProFlu+/ProFAST+ (PFlu/PFAST), FilmArray Respiratory Panel (RP), cobas(®) Influenza A/B test (cIAB), and Xpert(®) Flu (Xpt) in a retrospective analysis of consecutive nasopharyngeal specimens received for a two-week period during the winter of 2015...
August 2017: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/28540320/delayed-diagnosis-of-tuberculous-meningitis-misdiagnosed-as-herpes-simplex-virus-1-encephalitis-with-the-filmarray-syndromic-polymerase-chain-reaction-panel
#5
Carlos A Gomez, Benjamin A Pinsky, Anne Liu, Niaz Banaei
The FilmArray meningitis/encephalitis (ME) panel is a novel syndromic, nucleic acid amplification test for diagnosis of acute meningitis and encephalitis. Emerging data on its performance are concerning for false-positive results. We present a case of tuberculous meningitis misdiagnosed as herpes simplex virus-1 encephalitis with the FilmArray ME panel. Strategies to mitigate erroneous results are discussed.
2017: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/28505570/clinical-evaluation-of-the-biofire-filmarray-%C3%A2-biothreat-e-test-for-the-diagnosis-of-ebola-virus-disease-in-guinea
#6
Françoise Gay-Andrieu, N'Fally Magassouba, Valentina Picot, Cynthia L Phillips, Christophe N Peyrefitte, Brigitte Dacosta, Ahmadou Doré, Fode Kourouma, Véronique Ligeon-Ligeonnet, Corentin Gauby, Christophe Longuet, Matt Scullion, Ousmane Faye, Jean Louis Machuron, Mark Miller
BACKGROUND: The recent West Africa Ebola outbreak highlighted the need to provide access to rapid, safe and reliable Ebola Virus Disease diagnostics. OBJECTIVES: The objective of this field study was to assess the clinical performance of the FilmArray(®) BioThreat-E test for the detection of Ebola Zaïre virus in whole blood in symptomatic patients suspected of Ebola Virus Disease in Conakry (Guinea) from March to July 2015. STUDY DESIGN: The BioThreat-E test was compared to the two RT-PCRs, using serum, implemented at Donka Hospital in the emergency context: an in-house developed quantitative one-step RT-PCR adapted from the Weidmann technique, and the RealStar(®) Filovirus RT-PCR Kit 1...
July 2017: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/28494766/filmarray%C3%A2-gi-panel-performance-for-the-diagnosis-of-acute-gastroenteritis-or-hemorragic-diarrhea
#7
Antonio Piralla, Giovanna Lunghi, Gianluigi Ardissino, Alessia Girello, Marta Premoli, Erika Bava, Milena Arghittu, Maria Rosaria Colombo, Alessandra Cognetto, Patrizia Bono, Giulia Campanini, Piero Marone, Fausto Baldanti
BACKGROUND: Acute gastroenteritis is a common cause of morbidity and mortality in humans worldwide. The rapid and specific identification of infectious agents is crucial for correct patient management. However, diagnosis of acute gastroenteritis is usually performed with diagnostic panels that include only a few pathogens. In the present bicentric study, the diagnostic value of FilmArray™ GI panels was assessed in unformed stool samples of patients with acute gastroenteritis and in a series of samples collected from pediatric patients with heamorragic diarrhea...
May 12, 2017: BMC Microbiology
https://www.readbyqxmd.com/read/28379561/rule-out-outbreak-24-hour-metagenomic-next-generation-sequencing-for-characterizing-respiratory-virus-source-for-infection-prevention
#8
Alexander L Greninger, Alpana Waghmare, Amanda Adler, Xuan Qin, Janet L Crowley, Janet A Englund, Jane M Kuypers, Keith R Jerome, Danielle M Zerr
Background.: Metagenomic next-generation sequencing (mNGS) has been used to uncover unusual causes of infectious diseases but has not been used routinely for the investigation of putative nosocomial outbreaks. Here, we describe the use of mNGS during investigation of a cluster of human rhinovirus (HRV)-positive infections on a high-risk pulmonary ward. Methods.: We performed mNGS on 6 midnasal turbinate swabs from 4 case-patients and 10 swabs from 9 control outpatients that tested positive for enterovirus/rhinovirus by the FilmArray system...
June 1, 2017: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/28348803/non-o1-non-o139-vibrio-cholerae-septicaemia-in-a-saudi-man-a-case-report
#9
Reham Kaki, Dalia El-Hossary, Asif Jiman-Fatani, Rahaf Al-Ghamdi
Background. The non-O1/non-O139 serogroups of Vibrio cholerae occur in diverse natural niches, and usually cause mild and self-limiting gastrointestinal illness. However, they have well-documented potential to cause invasive and extra-intestinal infections among immunocompromised patients. Furthermore, their ability to grow in low-salinity surface water, and the existence of asymptomatic human carriers, suggest novel acquisition routes for this unusual infection, even in people without obvious risk factors...
February 2017: JMM Case Reports
https://www.readbyqxmd.com/read/28255915/microbiologic-methods-in-the-diagnostics-of-upper-respiratory-tract-pathogens
#10
J Kompanikova, A Zumdick, M Neuschlova, V Sadlonova, E Novakova
Upper respiratory tract infection (URI) is a nonspecific term used to describe acute infections involving the nose, paranasal sinuses, pharynx, and larynx above the vocal cords. The aim of this study was to provide a summary of the most common pathogens of URI and to compare advantages and disadvantages of traditional and new rapid microbiological tests used to identify them. Blood samples were simultaneously examined by the enzyme-linked immunosorbent assay (ELISA) and by the FilmArray Respiratory Panel for eight different pathogens in a total of 15 tests performed in nasopharyngeal swabs...
March 3, 2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28250000/assessment-of-rapid-blood-culture-identification-result-interpretation-and-antibiotic-prescribing-practices
#11
Linsey M Donner, W Scott Campbell, Elizabeth Lyden, Trevor C Van Schooneveld
Rapid pathogen identification can alter antibiotic prescribing practices if interpreted correctly. Microbiology reporting can be difficult to understand, and new technology has made it more challenging. Nebraska Medicine recently implemented the BioFire FilmArray blood culture identification panel (BCID) coupled with stewardship-based education on interpretation. Physician BCID result interpretation and prescribing were assessed via an electronic survey, with a response rate of 40.8% (156/382 surveys). Seven questions required respondents to interpret BCID results, identify the most likely pathogen, and then choose therapy based on the results...
May 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28175047/p303-gastrointestinal-infectious-agents-detected-by-biofire-filmarray-gi-pcr-panel-stool-testing-in-active-inflammatory-bowel-disease-are-common-and-associated-with-a-more-benign-course-of-ibd
#12
J Limsrivilai, R W Stidham, S Govani, A Waljee, B Gutermuth, A Brown, E Briggs, K Rao, P D Higgins
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28166743/molecular-point-of-care-testing-for-respiratory-viruses-versus-routine-clinical-care-in-adults-with-acute-respiratory-illness-presenting-to-secondary-care-a-pragmatic-randomised-controlled-trial-protocol-respoc
#13
Nathan J Brendish, Ahalya K Malachira, Tristan W Clark
BACKGROUND: Respiratory viruses are associated with a huge socio-economic burden and are responsible for a large proportion of acute respiratory illness in hospitalised adults. Laboratory PCR is accurate but takes at least 24 h to generate a result to clinicians and antigen-based point-of-care tests (POCT) lack sensitivity. Rapid molecular platforms, such as the FilmArray Respiratory Panel, have equivalent diagnostic accuracy to laboratory PCR and can generate a result in 1 h making them deployable as POCT...
February 6, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28159444/detection-and-differentiation-of-norovirus-genogroups-i-and-ii-from-clinical-stool-specimens-using-real-time-pcr
#14
Poornima Ramanan, M J Espy, Reeti Khare, M J Binnicker
A real-time RT-PCR assay was designed to detect and differentiate norovirus genogroups I (GI) and II (GII), with primers and probes targeting the nonstructural polyprotein gene. Stool samples (n = 100) submitted for routine testing by the BioFire FilmArray® GI panel were also tested by the norovirus GI/GII real-time PCR assays. When compared to the FilmArray GI panel, the norovirus real-time PCR assay demonstrated a sensitivity of 77.5% (62/80) and specificity of 95% (19/20). Specimens yielding discordant results (n = 19) were tested at two outside laboratories for adjudication...
April 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/28122874/is-follow-up-testing-with-the-filmarray-gastrointestinal-multiplex-pcr-panel-necessary
#15
Sholhui Park, Matthew M Hitchcock, Carlos A Gomez, Niaz Banaei
The FilmArray gastrointestinal (GI) panel (BioFire Diagnostics, Salt Lake City, UT) is a simple, sample-to-answer, on-demand, multiplex, nucleic acid amplification test for syndromic diagnosis of infectious gastroenteritis. The aim of this study was to measure the yield of follow-up testing with FilmArray GI panel within 4 weeks of an initial test. Consecutive adult and pediatric patients tested at an academic institution between August 2015 and June 2016 were included in this study. Of 145 follow-up tests in 106 unique patients with an initial negative result, 134 (92...
April 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28114152/enhanced-identification-of-group-b-streptococcus-and-escherichia-coli-in-young-infants-with-meningitis-using-the-biofire-filmarray-meningitis-encephalitis-panel
#16
Harbir Singh Arora, Basim I Asmar, Hossein Salimnia, Prashant Agarwal, Sanjay Chawla, Nahed Abdel-Haq
FilmArray Meningitis/Encephalitis (ME) polymerase chain reaction (PCR) panel was tested on 62 cerebrospinal fluid (CSF) samples from young infants (0-3 months) with suspected meningitis and compared with CSF cultures. Twelve CSF samples from 9 infants were positive by ME PCR panel (10 Group B Streptococcus (GBS) and 2 Escherichia coli) of which only 5 were positive by culture. The 7 CSF samples that were positive only by ME PCR panel were obtained from infants who had received prior antibiotic treatment. The ME PCR panel can be a useful tool in the rapid diagnosis of bacterial meningitis in pretreated young infants...
July 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28032602/detection-of-alk-rearrangements-in-lung-cancer-patients-using-a-homebrew-pcr-assay
#17
Hui Yu, JianHua Chang, Fang Liu, Qifeng Wang, YongMing Lu, ZhuanXu Zhang, Jiabing Shen, Qing Zhai, Xia Meng, Jialei Wang, Xun Ye
Lung cancer patients with anaplastic lymphoma kinase (ALK) rearrangements are candidates for targeted therapeutics. However, patients must be tested with a companion diagnostic assay to realize their ALK rearrangement status. We analyzed the publicly available E-GEOD-31210 microarray dataset and identified a non-coding RNA, sweyjawbu, which is strongly associated with ALK rearrangements. We validated these results using quantitative real-time PCR in an independent cohort consisting of 4 cell lines and 83 clinical samples...
January 31, 2017: Oncotarget
https://www.readbyqxmd.com/read/27957599/evaluation-of-the-biofire-filmarray%C3%A2-gastrointestinalpanel-in-a-midwestern-academic-hospital
#18
C N Murphy, R C Fowler, P C Iwen, P D Fey
The BioFire FilmArray® Gastrointestinal Panel (GIP) was implemented to replace traditional stool culture and enzyme immunoassay (EIA) testing for stool pathogens. The purpose of this study was to evaluate the detection rate, incidence of coinfection, and culture recovery rate of gastrointestinal (GI) pathogens detected by the GIP over a 1-year period. A total of 2257 stools collected from January to December 2015 were tested using the GIP. Clostridium difficile colonization was also evaluated by an antigen/toxin EIA and confirmatory polymerase chain reaction (PCR)...
April 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/27928081/multiplex-polymerase-chain-reaction-for-detection-of-gastrointestinal-pathogens-in-migrant-workers-in-qatar
#19
John M Humphrey, Sanjay Ranbhise, Emad Ibrahim, Hamad E Al-Romaihi, Elmoubasher Farag, Laith J Abu-Raddad, Marshall J Glesby
The causes of infectious diarrhea among the migrant worker population in Qatar are not well understood. We conducted a prospective observational study to understand the demographic and clinical characteristics and infectious causes of diarrhea among migrant workers in Doha, Qatar. A total of 126 male workers presenting to the Qatar Red Crescent Worker's Health Center outpatient clinic or emergency department were studied over a 5-month period in 2015-2016. Epidemiologic surveys were administered to all subjects and the prevalence of 22 different stool pathogens was determined using multiplex polymerase chain reaction (PCR) (FilmArray(®) Gastrointestinal PCR)...
December 7, 2016: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/27795349/utility-of-filmarray-meningitis-encephalitis-panel-during-outbreak-of-brainstem-encephalitis-caused-by-enterovirus-in-catalonia-in-2016
#20
LETTER
Cristian Launes, Didac Casas-Alba, Claudia Fortuny, Ana Valero-Rello, Maria Cabrerizo, Carmen Muñoz-Almagro
No abstract text is available yet for this article.
January 2017: Journal of Clinical Microbiology
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