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https://www.readbyqxmd.com/read/28379561/rule-out-outbreak-24-hour-metagenomic-next-generation-sequencing-for-characterizing-respiratory-virus-source-for-infection-prevention
#1
Alexander L Greninger, Alpana Waghmare, Amanda Adler, Xuan Qin, Janet L Crowley, Janet A Englund, Jane M Kuypers, Keith R Jerome, Danielle M Zerr
Background.: Metagenomic next-generation sequencing (mNGS) has been used to uncover unusual causes of infectious diseases but has not been used routinely for the investigation of putative nosocomial outbreaks. Here, we describe the use of mNGS during investigation of a cluster of human rhinovirus (HRV)-positive infections on a high-risk pulmonary ward. Methods.: We performed mNGS on 6 midnasal turbinate swabs from 4 case-patients and 10 swabs from 9 control outpatients that tested positive for enterovirus/rhinovirus by the FilmArray system...
April 4, 2017: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/28348803/non-o1-non-o139-vibrio-cholerae-septicaemia-in-a-saudi-man-a-case-report
#2
Reham Kaki, Dalia El-Hossary, Asif Jiman-Fatani, Rahaf Al-Ghamdi
Background. The non-O1/non-O139 serogroups of Vibrio cholerae occur in diverse natural niches, and usually cause mild and self-limiting gastrointestinal illness. However, they have well-documented potential to cause invasive and extra-intestinal infections among immunocompromised patients. Furthermore, their ability to grow in low-salinity surface water, and the existence of asymptomatic human carriers, suggest novel acquisition routes for this unusual infection, even in people without obvious risk factors...
February 2017: JMM Case Reports
https://www.readbyqxmd.com/read/28255915/microbiologic-methods-in-the-diagnostics-of-upper-respiratory-tract-pathogens
#3
J Kompanikova, A Zumdick, M Neuschlova, V Sadlonova, E Novakova
Upper respiratory tract infection (URI) is a nonspecific term used to describe acute infections involving the nose, paranasal sinuses, pharynx, and larynx above the vocal cords. The aim of this study was to provide a summary of the most common pathogens of URI and to compare advantages and disadvantages of traditional and new rapid microbiological tests used to identify them. Blood samples were simultaneously examined by the enzyme-linked immunosorbent assay (ELISA) and by the FilmArray Respiratory Panel for eight different pathogens in a total of 15 tests performed in nasopharyngeal swabs...
March 3, 2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28250000/assessment-of-rapid-blood-culture-identification-results-interpretation-and-antibiotic-prescribing-practices
#4
Linsey M Donner, W Scott Campbell, Elizabeth Lyden, Trevor C Van Schooneveld
Background: Rapid pathogen identification can alter antibiotic prescribing if interpreted correctly. Microbiology reporting can be difficult to understand and new technology has made it more challenging. Nebraska Medicine recently implemented the Biofire FilmArray® Blood Culture Identification Panel (BCID) coupled with stewardship-based education on interpretation.Methods: Physician BCID result interpretation and prescribing was assessed via an electronic survey with a response rate of 40.8% (156/382). Seven questions required respondents to interpret BCID results and identify the most likely pathogen, then choose therapy based on the results...
March 1, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28175047/p303-gastrointestinal-infectious-agents-detected-by-biofire-filmarray-gi-pcr-panel-stool-testing-in-active-inflammatory-bowel-disease-are-common-and-associated-with-a-more-benign-course-of-ibd
#5
J Limsrivilai, R W Stidham, S Govani, A Waljee, B Gutermuth, A Brown, E Briggs, K Rao, P D Higgins
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28166743/molecular-point-of-care-testing-for-respiratory-viruses-versus-routine-clinical-care-in-adults-with-acute-respiratory-illness-presenting-to-secondary-care-a-pragmatic-randomised-controlled-trial-protocol-respoc
#6
Nathan J Brendish, Ahalya K Malachira, Tristan W Clark
BACKGROUND: Respiratory viruses are associated with a huge socio-economic burden and are responsible for a large proportion of acute respiratory illness in hospitalised adults. Laboratory PCR is accurate but takes at least 24 h to generate a result to clinicians and antigen-based point-of-care tests (POCT) lack sensitivity. Rapid molecular platforms, such as the FilmArray Respiratory Panel, have equivalent diagnostic accuracy to laboratory PCR and can generate a result in 1 h making them deployable as POCT...
February 6, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28159444/detection-and-differentiation-of-norovirus-genogroups-i-and-ii-from-clinical-stool-specimens-using-real-time-pcr
#7
Poornima Ramanan, M J Espy, Reeti Khare, M J Binnicker
A real-time RT-PCR assay was designed to detect and differentiate norovirus genogroups I (GI) and II (GII), with primers and probes targeting the nonstructural polyprotein gene. Stool samples (n = 100) submitted for routine testing by the BioFire FilmArray® GI panel were also tested by the norovirus GI/GII real-time PCR assays. When compared to the FilmArray GI panel, the norovirus real-time PCR assay demonstrated a sensitivity of 77.5% (62/80) and specificity of 95% (19/20). Specimens yielding discordant results (n = 19) were tested at two outside laboratories for adjudication...
April 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/28122874/is-follow-up-testing-with-the-filmarray-gastrointestinal-multiplex-pcr-panel-necessary
#8
Sholhui Park, Matthew M Hitchcock, Carlos A Gomez, Niaz Banaei
The FilmArray gastrointestinal (GI) panel (BioFire Diagnostics, Salt Lake City, UT) is a simple, sample-to-answer, on-demand, multiplex, nucleic acid amplification test for syndromic diagnosis of infectious gastroenteritis. The aim of this study was to measure the yield of follow-up testing with FilmArray GI panel within 4 weeks of an initial test. Consecutive adult and pediatric patients tested at an academic institution between August 2015 and June 2016 were included in this study. Of 145 follow-up tests in 106 unique patients with an initial negative result, 134 (92...
April 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28114152/enhanced-identification-of-group-b-streptococcus-and-escherichia-coli-in-young-infants-with-meningitis-using-the-biofire-filmarray-meningitis-encephalitis-panel
#9
Harbir Singh Arora, Basim Isa Asmar, Hossein Salimnia, Prashant Agarwal, Sanjay Chawla, Nahed Abdel-Haq
FilmArray® Meningitis/Encephalitis (ME) PCR Panel was tested on 62 CSF samples from young infants (0-3 months) with suspected meningitis and compared with CSF cultures. Twelve CSF samples from 9 infants were positive by ME PCR panel (10 GBS, 2 E. coli) of which only 5 were positive by culture. The 7 CSF samples that were positive only by ME PCR panel were obtained from infants who had received prior antibiotic treatment. The ME PCR Panel can be a useful tool in the rapid diagnosis of bacterial meningitis in pretreated young infants...
January 19, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28032602/detection-of-alk-rearrangements-in-lung-cancer-patients-using-a-homebrew-pcr-assay
#10
Hui Yu, JianHua Chang, Fang Liu, Qifeng Wang, YongMing Lu, ZhuanXu Zhang, Jiabing Shen, Qing Zhai, Xia Meng, Jialei Wang, Xun Ye
Lung cancer patients with anaplastic lymphoma kinase (ALK) rearrangements are candidates for targeted therapeutics. However, patients must be tested with a companion diagnostic assay to realize their ALK rearrangement status. We analyzed the publicly available E-GEOD-31210 microarray dataset and identified a non-coding RNA, sweyjawbu, which is strongly associated with ALK rearrangements. We validated these results using quantitative real-time PCR in an independent cohort consisting of 4 cell lines and 83 clinical samples...
January 31, 2017: Oncotarget
https://www.readbyqxmd.com/read/27957599/evaluation-of-the-biofire-filmarray%C3%A2-gastrointestinalpanel-in-a-midwestern-academic-hospital
#11
C N Murphy, R C Fowler, P C Iwen, P D Fey
The BioFire FilmArray® Gastrointestinal Panel (GIP) was implemented to replace traditional stool culture and enzyme immunoassay (EIA) testing for stool pathogens. The purpose of this study was to evaluate the detection rate, incidence of coinfection, and culture recovery rate of gastrointestinal (GI) pathogens detected by the GIP over a 1-year period. A total of 2257 stools collected from January to December 2015 were tested using the GIP. Clostridium difficile colonization was also evaluated by an antigen/toxin EIA and confirmatory polymerase chain reaction (PCR)...
April 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/27928081/multiplex-polymerase-chain-reaction-for-detection-of-gastrointestinal-pathogens-in-migrant-workers-in-qatar
#12
John M Humphrey, Sanjay Ranbhise, Emad Ibrahim, Hamad E Al-Romaihi, Elmoubasher Farag, Laith J Abu-Raddad, Marshall J Glesby
The causes of infectious diarrhea among the migrant worker population in Qatar are not well understood. We conducted a prospective observational study to understand the demographic and clinical characteristics and infectious causes of diarrhea among migrant workers in Doha, Qatar. A total of 126 male workers presenting to the Qatar Red Crescent Worker's Health Center outpatient clinic or emergency department were studied over a 5-month period in 2015-2016. Epidemiologic surveys were administered to all subjects and the prevalence of 22 different stool pathogens was determined using multiplex polymerase chain reaction (PCR) (FilmArray(®) Gastrointestinal PCR)...
December 7, 2016: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/27795349/utility-of-filmarray-meningitis-encephalitis-panel-during-outbreak-of-brainstem-encephalitis-caused-by-enterovirus-in-catalonia-in-2016
#13
LETTER
Cristian Launes, Didac Casas-Alba, Claudia Fortuny, Ana Valero-Rello, Maria Cabrerizo, Carmen Muñoz-Almagro
No abstract text is available yet for this article.
January 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/27771208/comparative-evaluation-of-the-filmarray-meningitis-encephalitis-molecular-panel-in-a-pediatric-population
#14
COMPARATIVE STUDY
Erin H Graf, Maria Victoria Farquharson, Ana María Cárdenas
We compared an FDA cleared molecular meningitis/encephalitis panel to lab developed viral PCRs and bacterial culture. Of the 67 viral PCR or bacterial culture-positive samples, 92.5% were positive for the same target by the panel. Of the 66 negative samples tested, no targets were detected by the panel, for an agreement of 96.2%.
January 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/27720206/performance-of-the-verigene%C3%A2-enteric-pathogens-test-biofire-filmarray%C3%A2-gastrointestinal-panel-and-luminex-xtag%C3%A2-gastrointestinal-pathogen-panel-for-detection-of-common-enteric-pathogens
#15
COMPARATIVE STUDY
Richard S P Huang, Coreen L Johnson, Lauryn Pritchard, Richard Hepler, Trang T Ton, James J Dunn
BACKGROUND: Multiplex syndromic panels have the capability of identifying causes of diarrheal illness. This study evaluated the performance characteristics of three multiplex molecular assays for the detection of common stool pathogens. METHODS: A total of 152 stool specimens were tested using three platforms: Verigene Enteric Pathogens Test (Verigene), Biofire FilmArray Gastrointestinal Panel (Biofire) and Luminex xTAG® Gastrointestinal Pathogen Panel (Luminex)...
December 2016: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/27599796/implementation-of-rapid-diagnostics-with-antimicrobial-stewardship
#16
Emi Minejima, Annie Wong-Beringer
Antimicrobial stewardship (ASP) is an intervention-based program to improve patient outcomes to infection while limiting spread of resistance and unintended consequences. Many rapid diagnostic tools are now FDA cleared for clinical use, with three evaluated across multiple settings: Matrix Assisted Laser Desorption Ionization Time-of-Flight Mass Spectrometry, Verigene, and FilmArray. Areas covered: This review will focus on studies published that evaluated ASP intervention with rapid diagnostic implementation on outcomes of infection...
November 2016: Expert Review of Anti-infective Therapy
https://www.readbyqxmd.com/read/27582513/direct-comparison-of-alere-i-and-cobas-liat-influenza-a-and-b-tests-for-rapid-detection-of-influenza-virus-infection
#17
Frederick S Nolte, Lori Gauld, Susan B Barrett
We compared two rapid, point-of care nucleic acid amplification tests for detection of influenza A and B viruses (Alere i [Alere] and cobas Liat [Roche Diagnostics]) with the influenza A and B virus test components of the FilmArray respiratory panel (BioFire Diagnostics) using 129 respiratory specimens collected in universal viral transport medium (80 influenza A virus and 16 influenza B virus positive) from both adult and pediatric patients. The sensitivities of the Alere test were 71.3% for influenza A virus and 93...
November 2016: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/27543412/clinical-impact-and-provider-acceptability-of-real-time-antimicrobial-stewardship-decision-support-for-rapid-diagnostics-in-children-with-positive-blood-culture-results
#18
Kevin Messacar, Amanda L Hurst, Jason Child, Kristen Campbell, Claire Palmer, Stacey Hamilton, Elaine Dowell, Christine C Robinson, Sarah K Parker, Samuel R Dominguez
KEY POINTS: Real-time antimicrobial stewardship decision support for rapid blood culture diagnostics is associated with improved times to optimal and effective antimicrobial therapies and decreased unnecessary antimicrobial use in children. The unsolicited intervention incorporated with result reporting was well accepted and resulted in high provider satisfaction. BACKGROUND: Rapid diagnostic technologies for infectious diseases have the potential to improve clinical outcomes, but guideline-recommended antimicrobial stewardship (AS) strategies are not currently optimized for rapid intervention...
August 19, 2016: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/27419071/detection-of-bacterial-pathogens-in-synovial-and-pleural-fluid-with-the-filmarray-blood-culture-identification-system
#19
Athanasios Michos, Alexandra Palili, Emmanouil I Koutouzis, Adina Sandu, Lilia Lykopoulou, Vassiliki P Syriopoulou
We report the use of FilmArray Blood Culture Identification (BCID) multiplex PCR system for pathogen detection from a child with septic arthritis that Streptococcus pyogenes was identified directly from synovial fluid and a child with complicated pneumonia with pleural effusion that Streptococcus pneumoniae was identified from pleural fluid.
2016: IDCases
https://www.readbyqxmd.com/read/27413189/the-first-fully-automated-molecular-diagnostic-panel-for-meningitis-and-encephalitis-how-well-does-it-perform-and-when-should-it-be-used
#20
Kimberly E Hanson
Rapid and accurate molecular diagnostic tests for the most common causes of infectious meningitis and encephalitis have the potential for high clinical impact. In this issue of the Journal of Clinical Microbiology, Leber et al. (J Clin Microbiol 54:2251-2261, 2016, http://dx.doi.org/10.1128/JCM.00730-16) report results from a large clinical study designed to prospectively assess the performance of the FilmArray meningitis/encephalitis panel compared to conventional methods.
September 2016: Journal of Clinical Microbiology
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