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Oral candida

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https://www.readbyqxmd.com/read/27913142/candida-species-from-oral-cavity-of-hiv-infected-children-exhibit-reduced-virulence-factors-in-the-haart-era
#1
Maristela Barbosa Portela, Elaine Lima de Amorim, Adrielle Mangabeira Santos, José Alexandre da Rocha Curvelo, Karol de Oliveira Martins, Cauli Lima Capillé, Rosangela Maria de Araújo Soares, Gloria Fernanda Barbosa de Araújo Castro
This study aimed to assess, in vitro, the biofilm viability and the phospholipase and protease production of Candida spp. from the saliva of HIV infected children and healthy controls, and to correlate the results with the use of medical data. A total of 79 isolates were analyzed: 48 Candida albicans isolates (33/15) and 20 Candida parapsilosis sensu lato complex isolates (12/8) (from HIV/control patients, respectively), and 8 Candida krusei, 1 Candida tropicalis, 1 Candida dubliniensis and 1 Candida guilliermondii from HIV patients...
November 29, 2016: Microbial Pathogenesis
https://www.readbyqxmd.com/read/27904074/prophylactic-effect-of-lactobacillus-pentosus-strain-s-pt84-on-candida-infection-and-gastric-inflammation-in-a-murine-gastrointestinal-candidiasis-model-errata
#2
Toshihiro Maekawa, A Sanae Ishijima, Masayuki Ida, Takayuki Izumo, Yoshiko Ono, Hiroshi Shibata, Shigeru Abe
We previously showed a prophylactic effect of Lactobacillus pentosus strain S-PT84 against oral candidiasis in mice. In the present study, we evaluated the protective effect of S-PT84 against Candida infection of the gastrointestinal tract. As the first step, we used an in vitro assay to compare the inhibitory effects of several lactobacilli (S-PT84 and Lactobacillus pentosus type strain JCM1558(T), Lactobacillus gasseri type strain JCM1131(T) and Lactobacillus casei type strain JCM1134(T)) on mycelial growth of Candida albicans...
2016: Medical Mycology Journal
https://www.readbyqxmd.com/read/27904057/potential-of-ravuconazole-and-its-prodrugs-as-the-new-oraltherapeutics-for-onychomycosis
#3
Hideyo Yamaguchi
Onychomycosis is a fungal infection of the nail apparatus caused by dermatophytes, Candida and non-dermatophytic molds. It is highly prevalent in the general population worldwide and also responsible for significant morbidity and complications and does not usually cure itself. Thus, the condition needs to be treated in view of physical and psychological problems produced. Currently, oral medications using terbinafine are the most effective therapy, but it has relatively limited therapeutic success, particularly for long-term management...
2016: Medical Mycology Journal
https://www.readbyqxmd.com/read/27904056/prophylactic-effect-of-lactobacillus-pentosus-strain-s-pt84-on-candida-infection-and-gastric-inflammation-in-a-murine-gastrointestinal-candidiasis-model
#4
Toshihiro Maekawa, A Sanae Ishijima, Masayuki Ida, Takayuki Izumo, Yoshiko Ono, Hiroshi Shibata, Shigeru Abe
We previously showed a prophylactic effect of Lactobacillus pentosus strain S-PT84 against oral candidiasis in mice. In the present study, we evaluated the protective effect of S-PT84 against Candida infection of the gastrointestinal tract. As the first step, we used an in vitro assay to compare the inhibitory effects of several lactobacilli (S-PT84 and Lactobacillus pentosus type strain JCM1558(T), Lactobacillus gasseri type strain JCM1131(T) and Lactobacillus casei type strain JCM1134(T)) on mycelial growth of Candida albicans...
2016: Medical Mycology Journal
https://www.readbyqxmd.com/read/27902418/effects-of-the-glucocorticoid-betamethasone-on-the-interaction-of-candida-albicans-with-human-epithelial-cells
#5
Ágnes Jakab, Selene Mogavero, Toni M Förster, Marina Pekmezovic, Nadja Jablonowski, Viktor Dombrádi, István Pócsi, Bernhard Hube
The glucocorticoid betamethasone (BM) is frequently employed in the clinical practice because of its anti-inflammatory and immunosuppressive properties. In this study, we investigated the effect of BM (1 and 2 mM) on the ability of Candida albicans to adhere to, invade and damage oral, intestinal or vaginal epithelial cells, as well as to elicit cytokine and chemokine release. BM at 2 mM concentration stimulated adherence of C. albicans to vaginal cells and facilitated the invasion of intestinal and vaginal epithelia without influencing the growth rate of invading C...
October 20, 2016: Microbiology
https://www.readbyqxmd.com/read/27897199/hydroxychavicol-a-phytochemical-targeting-cutaneous-fungal-infections
#6
Intzar Ali, Naresh Kumar Satti, Prabhu Dutt, Rajendra Prasad, Inshad Ali Khan
The present study was designed to investigate the potency of hydroxychavicol on selected cutaneous human pathogenic fungi by the use of in vitro and in vivo assays and mechanistic characterization along with toxicological effects. Hydroxychavicol consistently displayed a fungicidal effect against all fungal species tested. Inoculum concentrations over the range of 10(4) to 10(7) CFU/ml did not significantly alter its antifungal potential and time-kill curve results revealed concentration-dependent killing...
November 29, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27891323/reduced-cx3cl1-secretion-contributes-to-the-susceptibility-of-oral-leukoplakia-associated-fibroblasts-to-candida-albicans
#7
Ran Cheng, Duo Li, Xueke Shi, Qinghong Gao, Changlei Wei, Xiaoyu Li, Yan Li, Hongmei Zhou
Candida leukoplakia (OLK) is a kind of oral leukoplakia combined with chronic candidal infection, which plays an important role in the malignant transformation of OLK. However, little is known about the etiology, including susceptibility of leukoplakia to candidal adhesion, invasion and infection. Some antimicrobial peptides secreted by oral epithelial cells or fibroblasts potentially have antifungal activities against Candida albicans (C. albicans). In this study, we established three co-culture models to simulate different C...
2016: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/27888114/limonene-reduces-hyperalgesia-induced-by-gp120-and-cytokines-by-modulation-of-il-1-%C3%AE-and-protein-expression-in-spinal-cord-of-mice
#8
Ana Claudia Piccinelli, Priscila Neder Morato, Marcelo Dos Santos Barbosa, Julio Croda, Jared Sampson, Xiangpeng Kong, Elisabete Castelon Konkiewitza, Edward B Ziff, Jaime Amaya-Farfan, Cândida Aparecida Leite Kassuya
AIMS: We have investigated the antihyperalgesic effects of limonene in mice that received intrathecal injection of gp120. MAIN METHODS: Male Swiss mice received gp120, IL-1β or TNF-α intrathecally or sterile saline as a control. A mechanicalsensitivity test was performed at 2 and 3h after the injection. Spinal cord and blood samples were isolated for protein quantification. KEY FINDINGS: Intrathecal administration of gp120 increased mechanical sensitivity measured with an electronic Von Frey apparatus, at 2 and 3h after the injections...
November 22, 2016: Life Sciences
https://www.readbyqxmd.com/read/27870138/promise-of-combining-antifungal-agents-in-denture-adhesives-to-fight-candida-species-infections
#9
Jorge L Garaicoa, Carol L Fischer, Amber M Bates, Julie Holloway, Gustavo Avila-Ortiz, Janet M Guthmiller, Georgia K Johnson, Clark Stanford, Kim A Brogden
PURPOSE: Several complications may arise in patients wearing complete prosthetic appliances, including denture-associated infections and mucosal stomatitis due to Candida species. This study evaluated the activity of anti-Candida agents in denture adhesive and the cytotoxicities of these preparations for primary human gingival epithelial (GE) keratinocytes. MATERIALS AND METHODS: The anti-Candida activities of antimicrobial peptides, antimicrobial lipids, and antifungal agents against C...
November 21, 2016: Journal of Prosthodontics: Official Journal of the American College of Prosthodontists
https://www.readbyqxmd.com/read/27826653/orally-administered-multispecies-probiotic-formulations-to-prevent-uro-genital-infections-a-randomized-placebo-controlled-pilot-study
#10
Valerio Mezzasalma, Enrico Manfrini, Emanuele Ferri, Marco Boccarusso, Patrizia Di Gennaro, Irene Schiano, Angela Michelotti, Massimo Labra
PURPOSE: The aim of this study was to evaluate in the vagina of 60 pre-menopausal women the detection of orally administered multispecies probiotic formulations showing anti-microbial properties in test in vitro. METHODS: A randomized, double-blind, three-arm parallel pilot study was carried out on 60 pre-menopausal women. Subjects were randomly divided in three groups (F_1, F_2, F_3). Each group received a daily oral administration of probiotic mixtures (for 14 days and at the day 21, 7 days after the wash-out) containing: Lactobacillus acidophilus and Lactobacillus reuteri (F_1), or Lactobacillus plantarum, Lactobacillus rhamnosus and Bifidobacterium animalis subsp...
November 9, 2016: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/27813064/factors-influencing-cure-rates-of-non-dermatophyte-mold-and-candida-onychomycosis-analysis-of-outcomes-in-81-patients-who-completed-treatment
#11
Ranthilaka R Ranawaka, S H Padmal de Silva
OBJECTIVES: Onychomycosis shows a poor response to current topical, oral, or device-related antifungal therapies. The aim of this study was to identify factors influencing the cure rates of non-dermatophyte mold and Candida onychomycosis. METHODS: Eighty-one patients who completed treatments were divided into "cured" and "non-cured" groups. The statistical significance of differences between the two groups was studied. RESULTS: Male gender (P < 0...
November 4, 2016: International Journal of Dermatology
https://www.readbyqxmd.com/read/27793169/oral-microbiota-carriage-in-patients-with-multibracket-appliance-in-relation-to-the-quality-of-oral-hygiene
#12
Katharina Klaus, Johanna Eichenauer, Rhea Sprenger, Sabine Ruf
BACKGROUND: The present study aimed to investigate the prevalence of oral microbiota (Candida species (spp.), Streptococcus mutans, and Lactobacilli) in patients with multibracket (MB) appliances in relation to the quality of oral hygiene. Saliva and plaque samples were collected from three groups of 25 patients each (good oral hygiene (GOH), poor oral hygiene (POH), and poor oral hygiene with white spot lesions (POH/WSL)). Counts of colony forming units (CFU) of the investigated oral microbiota were compared using Chi-square and Mann-Whitney U tests...
October 28, 2016: Head & Face Medicine
https://www.readbyqxmd.com/read/27791473/mining-the-oral-mycobiome-methods-components-and-meaning
#13
Patricia I Diaz, Bo-Young Hong, Amanda K Dupuy, Linda D Strausbaugh
Research on oral fungi has centered on Candida. However, recent internal transcribed spacer (ITS)-based studies revealed a vast number of fungal taxa as potential oral residents. We review DNA-based studies of the oral mycobiome and contrast them with cultivation-based surveys, showing that most genera encountered by cultivation have also been detected molecularly. Some taxa such as Malassezia, however, appear in high prevalence and abundance in molecular studies but have not been cultivated. Important technical and bioinformatic challenges to ITS-based oral mycobiome studies are discussed...
October 28, 2016: Virulence
https://www.readbyqxmd.com/read/27790459/estimation-of-antimicrobial-properties-of-aqueous-and-alcoholic-extracts-of-salvadora-persica-miswak-on-oral-microbial-pathogens-an-invitro-study
#14
Salman Siddeeqh, Amrita Parida, Maji Jose, Vidya Pai
INTRODUCTION: Twigs of Salvadora persica (Miswak) plant are being used as a means of oral hygiene since ages for brushing teeth. Though clinical research and trials have shown promising results on effectiveness of Miswak, but some reports are conflicting. AIM: To evaluate the antimicrobial activity of crude aqueous and alcoholic extracts of Salvadora persica (Miswak) against the common microbial pathogens causing dental caries and periodontitis. MATERIALS AND METHODS: A prospective study of one year duration was conducted in Yenopoya dental and medical college, Mangalore...
September 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27770763/comparative-assessment-of-selected-intraoral-microorganisms-%C3%A2-potential-factors-for-peri-surgical-management-complications
#15
Paweł J. Zawadzki, Bohdan Starościak, Konrad Perkowski, Wanda Baltaza, Marcin Padzik, Krzysztof Pionkowski, Lidia Chomicz
In this research, a comparative analysis of results of investigations involving different human populations, in terms of a relation between the oral cavity health and the species composition of mouth microbiota is reported. The purpose of this analysis was to identify and assess microorganisms that could cause health complications in patients with neoplasm requiring dental problem-related surgical management. The patients with the oral cancer surgically treated and those without neoplasm were assessed for their oral health: status of teeth, gingiva, periodontium, and occurrence of inflammatory processes...
October 1, 2016: Annals of Parasitology
https://www.readbyqxmd.com/read/27768221/renal-fungus-ball-a-challenging-clinical-problem
#16
Wei Phin Tan, Ulku C Turba, Leslie A Deane
INTRODUCTION: We describe a case of renal pelvi-ureteric fungus ball managed with placement of two nephrostomy tubes and amphotericin B irrigation through a nephrostomy tube with the other to free drain. CASE REPORT: A 46-year-old man with uncontrolled Type 2 diabetes mellitus was referred to the urology clinic for workup of recurrent urinary tract infection. Urine culture grew Candida albicans. The patient was started on oral fluconazole therapy. Cystoscopy and cystogram revealed a grade 3 left vesicoureteral reflux and right retrograde pyelogram revealed a filling defect in the right renal pelvis extending into the proximal ureter with severe hydroureteronephrosis...
October 15, 2016: Urologia
https://www.readbyqxmd.com/read/27757368/antifungal-activity-of-dual-combination-of-hydroxychavicol-with-commercialized-agents-against-oral-candida-species
#17
Wan Harun Himratul-Aznita, Che Omran Nor-Zulaila, Khairuddin Nurul-Fatihah
Candida spp. is the most prevalent species causing systemic fungal infections. The effect of antifungal agents were screened in vitro and their synergism effect were determined between hydroxychavicol (HC) in association with commercialized antifungal drugs-amphotericin B (AMB), and 5-fluorocytosine (5-FC) alone and in combination against five different oral Candida spp. in their planktonic states at different ratio (1:1 v/v; 1:2 v/v and 2:1 v/v). In vitro susceptibilities of Candida spp. to HC and commercialized antifungal agents were investigated by broth microdilution method as described by Clinical and Laboratory Standards Institute M38-A2...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27750097/food-safety-in-scavenger-conservation-diet-associated-exposure-to-livestock-pharmaceuticals-and-opportunist-mycoses-in-threatened-cinereous-and-egyptian-vultures
#18
Guillermo Blanco, Alexandra Junza, Dolores Barrón
Pharmaceuticals from veterinary treatments may enter terrestrial food webs when medicated livestock are available to wildlife in supplementary feeding stations aimed at the conservation of endangered scavengers. Here, we hypothesized that the exposure risk to livestock fluoroquinolones, as indicators of pharmaceutical burden in food, is related to the variable reliance of scavengers on domestic versus wild animal carcasses. Since the misuse of broad-spectrum antibiotics is a major predisposing factor for opportunistic mycoses, we evaluated disease signs potentially associated with diet-dependent drug exposure in nestlings of two threatened vultures...
October 14, 2016: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/27745775/new-denture-adhesive-containing-miconazole-nitrate-polymeric-microparticles-antifungal-adhesive-force-and-toxicity-properties
#19
Andrés Felipe Cartagena, Luís Antonio Esmerino, Rogerio Polak-Junior, Sibelli Olivieri Parreiras, Milton Domingos Michél, Paulo Vitor Farago, Nara Hellen Campanha
OBJECTIVE: The purpose of this study was to develop a new oral drug delivery system by incorporating polymeric miconazole nitrate (MN) microparticles on an experimental antifungal denture adhesive (DA). METHODS: Spray drying Eudragit L-100 (E) and Gantrez MS-955 (G) MN-microparticles were incorporated in DA. DAE1, DAG1, DAEG1, DAE2, DAG2, DAEG2 groups were obtained from the combination of polymers used in MN-microparticles (E, G and EG) and concentration of MN into DA (1, for 1% and 2, for 2%)...
October 10, 2016: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/27741258/candida-albicans-carriage-in-children-with-severe-early-childhood-caries-s-ecc-and-maternal-relatedness
#20
Jin Xiao, Yonghwi Moon, Lihua Li, Elena Rustchenko, Hironao Wakabayashi, Xiaoyi Zhao, Changyong Feng, Steven R Gill, Sean McLaren, Hans Malmstrom, Yanfang Ren, Robert Quivey, Hyun Koo, Dorota T Kopycka-Kedzierawski
INTRODUCTION: Candida albicans has been detected together with Streptococcus mutans in high numbers in plaque-biofilm from children with early childhood caries (ECC). The goal of this study was to examine the C. albicans carriage in children with severe early childhood caries (S-ECC) and the maternal relatedness. METHODS: Subjects in this pilot cross-sectional study were recruited based on a convenient sample. DMFT(S)/dmft(s) caries and plaque scores were assessed during a comprehensive oral exam...
2016: PloS One
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