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https://www.readbyqxmd.com/read/28188605/-cancer-and-mycoses-and-literature-review
#1
M Develoux
Various infectious agents are classical risk factors for cancer including bacteria, viruses and parasites. There is less evidence concerning the implication of fungal infection in carcinogenesis. The role of chronic Candida infection in the development of squamous cell carcinoma has been suspected for years. Candida sp are more prevalent in potentially malignant disorder and cancer of the oral mucosa. Other epidemiological evidence of a link between Candida infection and cancer is what is observed in patients with Autoimmune Polyendocrinopathy Candidiasis Ectodermal Dystrophy (APECED)...
February 11, 2017: Bulletin de la Société de Pathologie Exotique
https://www.readbyqxmd.com/read/28184328/frequency-of-candidiasis-and-colonization-of-candida-albicans-in-relation-to-oral-contraceptive-pills
#2
Atousa Aminzadeh, Ali Sabeti Sanat, Saeed Nik Akhtar
BACKGROUND: Candidiasis, the infection caused by Candida albicans, is one of the most common infections of the oral cavity in humans. Candidiasis causes irritation and is known for its carcinogenic effects. Thus, it is important to recognize the predisposing factors for this opportunistic infection. Several previous studies have demonstrated an increased frequency of vaginal candidiasis in relation to oral contraceptive consumption. OBJECTIVES: Only a few studies on the relation between oral contraceptives and oral candidiasis have been previously conducted...
October 2016: Iranian Red Crescent Medical Journal
https://www.readbyqxmd.com/read/28180946/new-developments-and-directions-in-the-clinical-application-of-the-echinocandins
#3
REVIEW
C C Chang, M A Slavin, S C-A Chen
The echinocandins-caspofungin, anidulafungin and micafungin-are semi-synthetic cyclic hexapeptide antimicrobial agents with modified N-linked acyl lipid side chains which anchor the compounds to the phospholipid bilayer of the fungal cell membrane, thereby inhibiting synthesis of fungal cell wall glucan. Over the last 10 years, echinocandins have become the first-line antifungal treatment of candidaemia and other forms of invasive candidiasis (IC). Echinocandins are generally well tolerated, but their use is limited by their requirement for daily intravenous dosing, lack of oral formulation and limited spectrum...
February 8, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/28178179/diminished-antimicrobial-peptide-and-antifungal-antibiotic-activities-against-candida-albicans-in-denture-adhesive
#4
Amber M Bates, Jorge L Garaicoa, Carol L Fischer, Kim A Brogden
The underlying causes of denture stomatitis may be related to the long-term use of adhesives, which may predispose individuals to oral candidiasis. In this study, we hypothesize that antimicrobial peptides and antifungal antibiotics have diminished anti-Candida activities in denture adhesive. To show this, nine antimicrobial peptides and five antifungal antibiotics with and without 1.0% denture adhesive were incubated with Candida albicans strains ATCC 64124 and HMV4C in radial diffusion assays. In gels with 1...
February 6, 2017: Antibiotics
https://www.readbyqxmd.com/read/28176789/the-intraspecies-diversity-of-c-albicans-triggers-qualitatively-and-temporally-distinct-host-responses-that-determine-the-balance-between-commensalism-and-pathogenicity
#5
F A Schönherr, F Sparber, F R Kirchner, E Guiducci, K Trautwein-Weidner, A Gladiator, N Sertour, U Hetzel, G T T Le, N Pavelka, C d'Enfert, M-E Bougnoux, C F Corti, S LeibundGut-Landmann
The host immune status is critical for preventing opportunistic infections with Candida albicans. Whether the natural fungal diversity that exists between C. albicans isolates also influences disease development remains unclear. Here, we used an experimental model of oral infection to probe the host response to diverse C. albicans isolates in vivo and found dramatic differences in their ability to persist in the oral mucosa, which inversely correlated with the degree and kinetics of immune activation in the host...
February 8, 2017: Mucosal Immunology
https://www.readbyqxmd.com/read/28175309/the-novel-oral-glucan-synthase-inhibitor-scy-078-shows-in-vitro-activity-against-sessile-and-planktonic-candida-spp
#6
Laura Judith Marcos-Zambrano, Marta Gómez-Perosanz, Pilar Escribano, Emilio Bouza, Jesús Guinea
No abstract text is available yet for this article.
February 8, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28169259/fluorescence-of-candida-in-diagnosis-of-oral-candidiasis
#7
L R Kumaraswamy Naik, Pushparaja Shetty, M S Krishna Prasad, Vimal Kumar Karnaker, Sarosh E Shroff, Lal P Madathil
BACKGROUND: Many pathogenic fungi fluoresce in hematoxylin and eosin stained sections, and Papanicolaou (PAP)-stained smears under ultraviolet illumination. In theory, this phenomenon could aid in the diagnosis of common fungal infections without the delay which is usually associated with special stains. OBJECTIVE: To evaluate the role of fluorescence as a rapid screening technique for oral infections caused by Candida organisms in exfoliative smears of oral candidiasis...
November 2016: Indian Journal of Dental Research: Official Publication of Indian Society for Dental Research
https://www.readbyqxmd.com/read/28165440/antimicrobial-efficacy-of-probiotic-containing-toothpastes-an-in-vitro-evaluation
#8
Ivana Parčina Amižić, Livia Cigić, Lidia Gavić, Marina Radić, Dolores Biočina Lukenda, Marija Tonkić, Ivana Goić Barišić
Aim To evaluate, in vitro antimicrobial ability of two probiotic toothpastes (one containing Lactobacillus paracasei, other containing Lactobacillus acidophilus) and one toothpaste without probiotic separately, and in a combination with two different mouthrinses (one containing essential oils and the other containing hexitidine). Methods Antimicrobial susceptibility was checked by using the ditch method and Clinical Laboratory Standard Institute (CLSI) guidelines. Two different toothpastes with probiotic, toothpaste without probiotic and two different mouthrinses were tested against the following selected microorganisms: Candida albicans, Candida tropicalis, Enterococcus faecalis, Streptococcus salivarius and Staphylococcus aureus...
February 1, 2017: Medicinski Glasnik
https://www.readbyqxmd.com/read/28159362/fungicidal-efficacy-of-various-honeys-against-fluconazole-resistant-candida-species-isolated-from-hiv-patients-with-candidiasis
#9
H Shokri, A Sharifzadeh
OBJECTIVE: Honey is well known to possess a broad spectrum of activity against medically important organisms. The purpose of this study was to assess the antifungal activity of different honeys against 40 fluconazole (FLU) resistant Candida species, including Candida albicans (C. albicans), Candida glabrata, Candida krusei and Candida tropicalis. MATERIALS AND METHODS: Three honey samples were collected from northern (Mazandaran, A), southern (Hormozgan, B) and central (Lorestan, C) regions of Iran...
January 31, 2017: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/28155565/oral-administration-of-amphotericin-b-nanoparticles-antifungal-activity-bioavailability-and-toxicity-in-rats
#10
Mahasen A Radwan, Bushra T AlQuadeib, Lidija Šiller, Matthew C Wright, Benjamin Horrocks
Amphotericin B (AMB) is used most commonly in severe systemic life-threatening fungal infections. There is currently an unmet need for an efficacious (AMB) formulation amenable to oral administration with better bioavailability and lower nephrotoxicity. Novel PEGylated polylactic-polyglycolic acid copolymer (PLGA-PEG) nanoparticles (NPs) formulations of AMB were therefore studied for their ability to kill Candida albicans (C. albicans). The antifungal activity of AMB formulations was assessed in C. albicans...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28148273/prevalence-of-candida-albicans-and-non-albicans-on-the-tongue-dorsa-of-elderly-people-living-in-a-post-disaster-area-a-cross-sectional-survey
#11
Toshiro Sato, Mitsuo Kishi, Miki Suda, Kiyomi Sakata, Haruki Shimoda, Hiroyuki Miura, Akira Ogawa, Seiichiro Kobayashi
BACKGROUND: Candida species are normal commensal organisms of the mouth. However, they can cause oral mucosal and severe systemic infections in persons with reduced immune function, which is common in the very elderly. In post-disaster areas, the number of elderly residents rapidly increases due to the outflow of younger generations. Hence, we examined the prevalence of Candida albicans and non-albicans in association with oral and systemic conditions, life style, medications, and living conditions...
February 1, 2017: BMC Oral Health
https://www.readbyqxmd.com/read/28142218/differential-effects-of-the-combination-of-tyrosol-with-chlorhexidine-gluconate-on-oral-biofilms
#12
Luana Ribeiro do Vale, Alberto Carlos Botazzo Delbem, Laís Salomão Arias, Renan Aparecido Fernandes, Ana Paula Miranda Vieira, Débora Barros Barbosa, Douglas Roberto Monteiro
OBJECTIVE: This study assessed the effect of tyrosol and chlorhexidine gluconate in combination against Candida albicans, Candida glabrata and Streptococcus mutans in the planktonic state or forming biofilms in vitro. MATERIALS AND METHODS: Checkerboard assays were performed for determination of minimum inhibitory concentration. Biofilms were cultivated during 24 h on specimens of acrylic resin and hydroxyapatite, and treated with the drugs alone or in combination twice a day for 1 min, during 3 days...
January 31, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28139480/evaluation-of-role-of-fixed-orthodontics-in-changing-oral-ecological-flora-of-opportunistic-microbes-in-children-and-adolescent
#13
Chandresh Shukla, Rajkumar Maurya, Vinod Singh, Manisha Tijare
OBJECTIVE: To determine the prevalence and counts of Streptococcus mutans and Candida species in orthodontic fixed appliance therapy patients and comparison of the efficiency of manual and electronic toothbrushes on minimizing plaque by reducing S. mutans and Candida species in above-mentioned patients. MATERIALS AND METHODS: The study was carried out on total number of sixty patients scheduled for orthodontic treatment (age group: 13-18). Plaque samples were collected to determine oral carriage of S...
January 2017: Journal of the Indian Society of Pedodontics and Preventive Dentistry
https://www.readbyqxmd.com/read/28138698/dose%C3%A2-dependent-effect-of-lysozyme-upon-candida%C3%A2-albicans-biofilm
#14
Sarra Sebaa, Nicolas Hizette, Zahia Boucherit-Otmani, Philippe Courtois
The present study investigated the in vitro effect of lysozyme (0-1,000 µg/ml) on Candida albicans (C. albicans) biofilm development. Investigations were conducted on C. albicans ATCC 10231 and on 10 clinical isolates from dentures. Strains were cultured aerobically at 37˚C in Sabouraud broth. Yeast growth was evaluated by turbidimetry. Biofilm biomass was quantified on a polystyrene support by crystal violet staining and on acrylic surfaces by counts of colony forming units. Lysozyme affected biofilm formation to a greater extent than it affected growth...
January 25, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28138378/the-frequency-antifungal-susceptibility-and-enzymatic-profiles-of-candida-species-isolated-from-neutropenic-patients
#15
Maral Gharaghani, Ali Rezaei-Matehkolaei, Ali Zarei Mahmoudabadi, Bijan Keikhaei
BACKGROUND: Neutropenia, as a predisposing factor for invasive candidiasis, is defined as a reduction in neutrophil count to less than 1500/mm(3). It is a common condition in patients with hematological malignancy and cytostatic chemotherapy. Extensive chemotherapy and prophylaxis with antifungals have increased the resistance of Candida isolates to antifungal drugs. Although, Candida albicans is the most common causative agent among neutropenic patients, there is an increasing rate of non-albicans species...
November 2016: Jundishapur Journal of Microbiology
https://www.readbyqxmd.com/read/28137806/scy-078-a-first-in-class-orally-active-antifungal-glucan-synthesis-inhibitor-pre-clinical-pharmacokinetics-and-pharmacodynamic-target-in-murine-models-of-disseminated-candidiasis
#16
Stephen A Wring, Ryan Randolph, SeongHee Park, George Abruzzo, Qing Chen, Amy Flattery, Graig Garrett, Michael Peel, Russell Outcalt, Kendall Powell, Michelle Trucksis, David Angulo, Katyna Borroto-Esoda
SCY-078 (MK-3118) is a novel, semi-synthetic derivative of enfumafungin and represents the first compound of the triterpene class of antifungals. SCY-078 exhibits potent inhibition of β- (1, 3)-D-glucan synthesis, an essential cell wall component of many pathogenic fungi including Candida spp. and Aspergillus spp. SCY-078 is currently in Phase 2 clinical development for the treatment of invasive fungal diseases. In vitro disposition studies to assess solubility, intestinal permeability, and metabolic stability were predictive of good oral bioavailability...
January 30, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28134351/candida-albicans-stimulates-streptococcus-mutans-microcolony-development-via-cross-kingdom-biofilm-derived-metabolites
#17
Dongyeop Kim, Arjun Sengupta, Tagbo H R Niepa, Byung-Hoo Lee, Aalim Weljie, Veronica S Freitas-Blanco, Ramiro M Murata, Kathleen J Stebe, Daeyeon Lee, Hyun Koo
Candida albicans is frequently detected with heavy infection of Streptococcus mutans in plaque-biofilms from children affected with early-childhood caries, a prevalent and costly oral disease. The presence of C. albicans enhances S. mutans growth within biofilms, yet the chemical interactions associated with bacterial accumulation remain unclear. Thus, this study was conducted to investigate how microbial products from this cross-kingdom association modulate S. mutans build-up in biofilms. Our data revealed that bacterial-fungal derived conditioned medium (BF-CM) significantly increased the growth of S...
January 30, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28131069/oral-candidal-speciation-virulence-and-antifungal-susceptibility-in-type-2-diabetes-mellitus
#18
Pratik N Patel, Parul Sah, Chetana Chandrashekar, Sudha Vidyasagar, J Venkata Rao, Mradul Tiwari, Raghu Radhakrishnan
OBJECTIVES: To determine the oral candidal carriage (OCC), activity of virulent factors and fluconazole susceptibility in subjects with type 2 diabetes mellitus (T2DM) and investigate their association with HbA1c measurements. MATERIALS AND METHODS: A cross sectional study was conducted on 100 diabetics and 100 healthy volunteers. The virulence was assessed by measuring the phospholipase activity and proteolysis index. Fluconazole susceptibility was performed using the gradient diffusion method...
January 17, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28124220/in-vitro-antifungal-susceptibility-of-oral-candida-isolates-from-patients-suffering-from-caries-and-chronic-periodontitis
#19
Janire De-la-Torre, María Esther Ortiz-Samperio, Cristina Marcos-Arias, Xabier Marichalar-Mendia, Elena Eraso, María Ángeles Echebarria-Goicouria, José Manuel Aguirre-Urizar, Guillermo Quindós
Caries and chronic periodontitis are common oral diseases where a higher Candida colonization is reported. Antifungal agents could be adjuvant drugs for the therapy of both clinical conditions. The aim of the current study has been to evaluate the in vitro activities of conventional and new antifungal drugs against oral Candida isolates from patients suffering from caries and/or chronic periodontitis. In vitro activities of amphotericin B, fluconazole, itraconazole, miconazole, nystatin, posaconazole and voriconazole against 126 oral Candida isolates (75 Candida albicans, 18 Candida parapsilosis, 11 Candida dubliniensis, six Candida guilliermondii, five Candida lipolytica, five Candida glabrata, four Candida tropicalis and two Candida krusei) from 61 patients were tested by the CLSI M27-A3 method...
January 25, 2017: Mycopathologia
https://www.readbyqxmd.com/read/28115357/synthesis-antifungal-activity-and-biocompatibility-of-novel-dabco-compounds-and-dabco-containing-denture-base-resins
#20
Jenny L Herman, Yapin Wang, Elizabeth Lilly, Thomas Lallier, Suleiman Hamdan, Xiaoming Xu, Paul L Fidel, Mairi C Noverr
The fungal pathogen Candida albicans causes a variety of oral infections including denture stomatitis, which is characterized by inflammation of the oral mucosa in direct contact with dentures, and affects a significant number of otherwise healthy denture wearers. While antifungal treatment reduces symptoms, infections are often recurrent. One strategy to address this problem is to incorporate compounds with fungicidal activities into denture materials to prevent colonization. Our laboratory synthesized novel derivatives of DABCO (1,4-diazabicyclo[2...
January 23, 2017: Antimicrobial Agents and Chemotherapy
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