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Oral candida

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https://www.readbyqxmd.com/read/29150834/il-22-neutralizing-autoantibodies-impair-fungal-clearance-in-murine-oropharyngeal-candidiasis-model
#1
Rudolf Bichele, Jaanika Kärner, Kai Truusalu, Imbi Smidt, Reet Mändar, Heather R Conti, Sarah L Gaffen, Pärt Peterson, Martti Laan, Kai Kisand
Protection against mucocutaneous candidiasis depends on the T helper (Th)17 pathway, as gene defects affecting its integrity result in inability to clear Candida albicans infection on body surfaces. Moreover, autoantibodies neutralizing Th17 cytokines have been related to chronic candidiasis in a rare inherited disorder called autoimmune polyendocriopathy candidiasis ectodermal dystrophy (APECED) caused by mutations in autoimmune regulator (AIRE) gene. However, the direct pathogenicity of these autoantibodies has not yet been addressed...
November 17, 2017: European Journal of Immunology
https://www.readbyqxmd.com/read/29149979/influence-of-oral-anaerobic-bacteria-on-hematopoietic-stem-cell-transplantation-patients-oral-mucositis-and-general-condition
#2
L Osakabe, A Utsumi, B Saito, Y Okamatsu, H Kinouchi, T Nakamaki, S Hironaka
OBJECTIVE: Oral mucositis (OM) caused by infection facilitated by myelosuppression and immunosuppression can be controlled through oral care. We investigated changes in oral anaerobic bacterial flora during the onset of OM with hematopoietic stem cell transplantation (HSCT). METHODS: This study included 19 patients who underwent HSCT. All received professional oral care before initiating the preparative regimen. We assessed OM, oral health and obtained microbial samples from the oral cavity during 5 assessment points: before initiating the preparative regimen; the day before HSCT (day 1); and at 7, 14, and 30 days after HSCT...
November 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/29142640/evaluation-of-c-albicans-and-s-mutans-adherence-on-different-provisional-crown-materials
#3
Gulsum Sayin Ozel, Mehmet Burak Guneser, Ozgur Inan, Ayce Unverdi Eldeniz
PURPOSE: Bacterial adhesion on provisional crown materials retained for a long time can influence the duration for which permanent prosthetic restorations can be healthily worn in the oral cavity. The aim of this study was to compare seven different commonly used provisional crown materials with regard to Streptococcus mutans and Candida albicans surface adhesion. MATERIALS AND METHODS: For each group, twenty specimens of the provisional fixed prosthodontic materials TemDent (Schütz), Imıdent (Imıcryl), Tab 2000 (Kerr), Structur Premium (Voco), Systemp (Ivoclar Vivadent), Acrytemp (Zhermack), and Takilon-BBF (Takilon) were prepared (diameter, 10...
October 2017: Journal of Advanced Prosthodontics
https://www.readbyqxmd.com/read/29133884/epha2-is-an-epithelial-cell-pattern-recognition-receptor-for-fungal-%C3%AE-glucans
#4
Marc Swidergall, Norma V Solis, Michail S Lionakis, Scott G Filler
Oral epithelial cells discriminate between pathogenic and non-pathogenic stimuli, and only induce an inflammatory response when they are exposed to high levels of a potentially harmful microorganism. The pattern recognition receptors (PRRs) in epithelial cells that mediate this differential response are poorly understood. Here, we demonstrate that the ephrin type-A receptor 2 (EphA2) is an oral epithelial cell PRR that binds to exposed β-glucans on the surface of the fungal pathogen Candida albicans. Binding of C...
November 13, 2017: Nature Microbiology
https://www.readbyqxmd.com/read/29125139/salivary-proteins-and-microbiota-as-biomarkers-for-early-childhood-caries-risk-assessment
#5
REVIEW
Abdullah S Hemadi, Ruijie Huang, Yuan Zhou, Jing Zou
Early childhood caries (ECC) is a term used to describe dental caries in children aged 6 years or younger. Oral streptococci, such as Streptococcus mutans and Streptococcus sorbrinus, are considered to be the main etiological agents of tooth decay in children. Other bacteria, such as Prevotella spp. and Lactobacillus spp., and fungus, that is, Candida albicans, are related to the development and progression of ECC. Biomolecules in saliva, mainly proteins, affect the survival of oral microorganisms by multiple innate defensive mechanisms, thus modulating the oral microflora...
November 10, 2017: International Journal of Oral Science
https://www.readbyqxmd.com/read/29123282/diagnosis-and-management-of-oral-candidosis
#6
M A O Lewis, D W Williams
Candida is a fungus (yeast) that is generally regarded as a normal and harmless member of the oral microbiome in humans. Should host defences against these commensals be compromised in any way then Candida can cause clinical signs and symptoms, which manifest as distinct forms of oral candidosis (candidiasis). Candida albicans is the most frequently isolated candidal species from the oral cavity, although a range of non-C. albicans Candida species are being increasingly encountered. The basic principle of the management of candidosis is to identify and eliminate any underlying host predisposing factor...
November 10, 2017: British Dental Journal
https://www.readbyqxmd.com/read/29112179/green-ultrasound-versus-conventional-synthesis-and-characterization-of-specific-task-pyridinium-ionic-liquid-hydrazones-tethering-fluorinated-counter-anions-novel-inhibitors-of-fungal-ergosterol-biosynthesis
#7
Nadjet Rezki, Salsabeel A Al-Sodies, Sheikh Shreaz, Rayees Ahmad Shiekh, Mouslim Messali, Vaseem Raja, Mohamed R Aouad
A series of specific task ionic liquids (ILs) based on a pyridiniumhydrazone scaffold in combination with hexafluorophosphate (PF₆(-)), tetrafluoroboron (BF₄(-)) and/or trifluoroacetate (CF₃COO(-)) counter anion, were designed and characterized by IR, NMR and mass spectrometry. The reactions were conducted under both conventional and green ultrasound procedures. The antifungal potential of the synthesized compounds 2-25 was investigated against 40 strains of Candida (four standard and 36 clinical isolates)...
November 7, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29109176/candidalysin-drives-epithelial-signaling-neutrophil-recruitment-and-immunopathology-at-the-vaginal-mucosa
#8
Jonathan P Richardson, Hubertine M E Willems, David L Moyes, Saeed Shoaie, Katherine S Barker, Shir Lynn Tan, Glen E Palmer, Bernhard Hube, Julian R Naglik, Brian M Peters
Unlike other forms of candidiasis, vulvovaginal candidiasis, caused primarily by the fungal pathogen Candida albicans, is a disease of immunocompetent and otherwise healthy women. Despite its prevalence, the fungal factors responsible for initiating symptomatic infection remain poorly understood. One of the hallmarks of vaginal candidiasis is the robust recruitment of neutrophils to the site of infection, which seemingly do not clear the fungus, but rather exacerbate disease symptomatology. Candidalysin, a newly discovered peptide toxin secreted by C...
November 6, 2017: Infection and Immunity
https://www.readbyqxmd.com/read/29101209/oral-epithelial-cells-orchestrate-innate-type-17-responses-to-candida-albicans-through-the-virulence-factor-candidalysin
#9
Akash H Verma, Jonathan P Richardson, Chunsheng Zhou, Bianca M Coleman, David L Moyes, Jemima Ho, Anna R Huppler, Kritika Ramani, Mandy J McGeachy, Ilgiz A Mufazalov, Ari Waisman, Lawrence P Kane, Partha S Biswas, Bernhard Hube, Julian R Naglik, Sarah L Gaffen
Candida albicans is a dimorphic commensal fungus that causes severe oral infections in immunodeficient patients. Invasion of C. albicans hyphae into oral epithelium is an essential virulence trait. Interleukin-17 (IL-17) signaling is required for both innate and adaptive immunity to C. albicans During the innate response, IL-17 is produced by γδ T cells and a poorly understood population of innate-acting CD4(+) αβ T cell receptor (TCRαβ)(+) cells, but only the TCRαβ(+) cells expand during acute infection...
November 3, 2017: Science Immunology
https://www.readbyqxmd.com/read/29101061/antimicrobial-efficacy-of-drug-blended-biosynthesized-colloidal-gold-nanoparticles-from-justicia-glauca-against-oral-pathogens-a-nanoantibiotic-approach
#10
Rayappan Emmanuel, Muthupandian Saravanan, Muhammad Ovais, Sethuramasamy Padmavathy, Zabta Khan Shinwari, Periyakaruppan Prakash
Antimicrobial resistance is a challenging task for researchers to develop new strategies. Green synthesis of AuNPs is an eco-friendly approach, which can be utilized in the microbistatic and microbicidal activities. The current study is focused on Justicia glauca (aqueous leaf extract) mediated AuNPs synthesis at room temperature by treating chloroaurate ions, that shows an antagonistic effect with Azithromycin (AZM) and Clarithromycin (CLR) antibiotics against oral pathogenic bacteria and fungi (Micrococcus luteus, Bacillus subtilis, Staphylococcus aureus, Streptococcus mutans, Lactobacillus acidophilus, Escherichia coli, Pseudomonas aeruginosa, Saccharomyces cerevisiae and Candida albicans)...
October 31, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29082569/deep-facial-mycosis-due-to-trichophyton-verrucosum-molecular-genetic-identification-of-the-dermatophyte-in-paraffin-embedded-tissue-case-report-and-review-of-the-literature
#11
REVIEW
U Wollina, G Hansel, S Uhrlaß, C Krüger, J Schönlebe, U-C Hipler, P Nenoff
Deep trichophytosis is relatively uncommon. The infection of the bearded area is also known as sycosis barbae or tinea barbae and can be caused by various fungal species, most often zoophilic fungi. We report on an 80-year-old male patient with severe sycosis barbae who had no animal contact and was treated with systemic antibiosis without improvement. Microbial and mycological investigations using swabs from oozing lesions revealed Staphylococcus hemolyticus and Candida parapsilosis. Histology demonstrated fungal elements in hair follicles...
October 30, 2017: Mycoses
https://www.readbyqxmd.com/read/29074435/the-natural-compound-magnolol-affects-growth-biofilm-formation-and-ultrastructure-of-oral-candida-isolates
#12
Jawad Behbehani, Sheikh Shreaz, Mohammad Irshad, Maribassapa Karched
The incidence of oral candidosis has increased in recent years due to the escalation in HIV-infection, cancer treatments, organ transplantation, and diabetes. In addition, corticosteroid use, dentures, and broad-spectrum antibiotic use have also contributed to the problem. Treatment of oral candidosis has continued to be problematic because of the potential toxicity of antifungals in clinical use, and, above all, development of drug resistance among patients. In this study, the antifungal effect of magnolol was investigated against 64 strains of Candida spp...
October 23, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29061737/the-antifungal-activity-of-oleylphosphocholine-olpc-on-in-vitro-and-in-vivo-candida-albicans-biofilms
#13
Michelle Holtappels, Erwin Swinnen, Lies De Groef, Jurgen Wuyts, Lieve Moons, Katrien Lagrou, Patrick Van Dijck, Soňa Kucharíková
In this study, we investigated the potential antifungal activity of the alkylphospholipid - oleylphosphocholine (OlPC), a structural analogue of miltefosine, on in vitro and in vivo Candida albicans biofilm formation. The effect of OlPC on in vitro and in vivo C. albicans biofilms was studied inside triple-lumen polyurethane catheters. In vivo biofilms were developed subcutaneously after catheter implant on the lower back of Sprague Dawley rats. Animals were treated orally with OlPC (20 mg/kg of body weight/day) for 7 days...
October 23, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29054393/isolation-of-candida-spp-from-denture-related-stomatitis-in-par%C3%A3-brazil
#14
Lurdete Maria Rocha Gauch, Simone Soares Pedrosa, Fabíola Silveira-Gomes, Renata Antunes Esteves, Silvia Helena Marques-da-Silva
The aim of this study was to isolate and identify Candida species from the oral cavity of denture wearers with denture-related stomatitis who were attended at the University Federal of Pará (Belém City, Pará State, Brazil). A total of 36 denture wearers with denture-related stomatitis were included, and type I (50%), type II (33%) and type III (17%) stomatitis were observed. Candida spp. were isolated from 89% of the cases and included five different Candida species. C. albicans was the most frequently recovered species (78% of the cases), followed by C...
July 29, 2017: Brazilian Journal of Microbiology: [publication of the Brazilian Society for Microbiology]
https://www.readbyqxmd.com/read/29040636/vt-1161-protects-mice-against-oropharyngeal-candidiasis-caused-by-fluconazole-susceptible-and-resistant-candida-albicans
#15
Timothy J Break, Jigar V Desai, Mukil Natarajan, Elise M N Ferre, Christina Henderson, Adrian M Zelazny, Ulrich Siebenlist, William J Hoekstra, Robert J Schotzinger, Edward P Garvey, Michail S Lionakis
Background: Candida albicans, the most common human fungal pathogen, causes chronic mucosal infections in patients with inborn errors of IL-17 immunity that rely heavily on chronic, often lifelong, azole antifungal agents for treatment. However, a rise in azole resistance has predicated a need for developing new antifungal drugs. Objectives: To test the in vitro and in vivo efficacy of VT-1161 and VT-1129 in the treatment of oropharyngeal candidiasis with azole-susceptible or -resistant C...
October 10, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29031236/inhibitory-effect-of-probiotic-lactobacilli-supernatants-on-single-and-mixed-non-albicans-candida-species-biofilm
#16
Yulong Tan, Matthias Leonhard, Doris Moser, Su Ma, Berit Schneider-Stickler
OBJECTIVES: Oral candidiasis is one of the most common human fungal infections. While most cases of the Candida species isolated from the oral cavity are Candida albicans, a large number of candidiasis is attributed to non-albicans Candida species. In this study, we aim to evaluate the in vitro inhibition of supernatants of Lactobacillus gasseri and Lactobacillus rhamnosus on the single and mixed species biofilm of non-albicans Candida species, including Candida tropicalis, Candida krusei and Candida parapsilosis...
October 6, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/29023454/antifungal-defense-of-probiotic-lactobacillus-rhamnosus-gg-is-mediated-by-blocking-adhesion-and-nutrient-depletion
#17
Daniela Mailänder-Sánchez, Christina Braunsdorf, Christian Grumaz, Christoph Müller, Stefan Lorenz, Philip Stevens, Jeanette Wagener, Betty Hebecker, Bernhard Hube, Franz Bracher, Kai Sohn, Martin Schaller
Candida albicans is an inhabitant of mucosal surfaces in healthy individuals but also the most common cause of fungal nosocomial blood stream infections, associated with high morbidity and mortality. As such life-threatening infections often disseminate from superficial mucosal infections we aimed to study the use of probiotic Lactobacillus rhamnosus GG (LGG) in prevention of mucosal C. albicans infections. Here, we demonstrate that LGG protects oral epithelial tissue from damage caused by C. albicans in our in vitro model of oral candidiasis...
2017: PloS One
https://www.readbyqxmd.com/read/29018413/effect-of-the-ethyl-acetate-fraction-of-eugenia-uniflora-on-proteins-global-expression-during-morphogenesis-in-candida-albicans
#18
Walicyranison P Silva-Rocha, Matheus F de Azevedo, Magda R A Ferreira, Julhiany de Fátima da Silva, Terezinha I E Svidzinski, Eveline P Milan, Luiz A L Soares, Keyla B F Rocha, Adriana F Uchôa, Maria J S Mendes-Giannini, Ana M Fusco Almeida, Guilherme M Chaves
Candida albicans is able to switch from yeast to hyphal growth and this is an essential step for tissue invasion and establishment of infection. Due to the limited drug arsenal used to treat fungal infections and the constant emergence of resistant strains, it is important to search for new therapeutic candidates. Therefore, this study aimed to investigate by proteomic analysis the role of a natural product (Eugenia uniflora) in impairing hypha formation in C. albicans. We also tested the potential action of E...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29016613/quantification-of-carious-pathogens-in-the-interdental-microbiota-of-young-caries-free-adults
#19
Denis Bourgeois, Alexandra David, Camille Inquimbert, Paul Tramini, Nicolas Molinari, Florence Carrouel
BACKGROUND: The majority of caries lesions in adults occur on the proximal tooth surfaces of the posterior teeth. A comprehensive study of the composition of the oral microbiota is fundamental for a better understanding of the etiology of interdental caries. METHODS: Twenty-five caries-free subjects (20-35 years old) were enrolled in the study. The interdental biofilm of four interdental sites were collected. The real-time polymerase chain reaction (PCR) methodology were used to quantify (i) the following bacteria: Streptococcus spp...
2017: PloS One
https://www.readbyqxmd.com/read/28993976/boric-acid-and-commercial-organoboron-products-as-inhibitors-of-drug-resistant-candida-albicans
#20
Bryan Larsen, Marija Petrovic, Francesco De Seta
Clinical use of boric acid as a topical antifungal in women who have failed standard antifungal therapy with azole drugs has been used sporadically for decades. Our previous in vitro work showing inhibition of Candida albicans growth was conducted on clinical isolates without antifungal drug susceptibility profiling. Here, we report that boric acid restricts growth of drug-resistant Candida albicans and inhibits hyphal growth and diminishes cell volume. The availability of over-the-counter organoboron compounds intended for use as oral nutritional supplements led us to determine if these also were inhibitory toward resistant Candida and show here that they also possess antifungal activity...
October 9, 2017: Mycopathologia
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