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https://www.readbyqxmd.com/read/29770082/first-reported-case-of-multidrug-resistant-candida-auris-in-canada
#1
I S Schwartz, G W Hammond
Candida auris is a fungal pathogen that has recently emerged as a global threat to public health. It was first described in Japan in 2009 and has since been reported in 17 countries on five continents. This case report describes the first reported case of multidrug-resistant C. auris in Canada. In May 2017, a 64-year-old individual was evaluated for chronic otitis externa. Past medical history included a recent hospitalization in India for elective oral surgery that was complicated by an odontogenic brain abscess...
July 6, 2017: Canada Communicable Disease Report, Relevé des Maladies Transmissibles Au Canada
https://www.readbyqxmd.com/read/29766652/mucosal-microflora-in-head-and-neck-cancer-patients
#2
A Almståhl, C Finizia, A Carlén, B Fagerberg-Mohlin, T Alstad
OBJECTIVE: To analyse the tongue and buccal microflora prospectively in head and neck cancer patients treated with radiation therapy (RT). METHODS: In 33 dentate patients, microbial samples from the tongue and buccal mucosa were collected pretreatment, during treatment, and 6 months, 1 year and 2 years post-treatment. Microorganisms associated with oral health and oral disorders were analysed using cultivation technique. Oral mucositis was scored at the appointment during treatment...
May 15, 2018: International Journal of Dental Hygiene
https://www.readbyqxmd.com/read/29755615/-candida-is-a-protractive-factor-of-chronic-oral-ulcers-among-usual-outpatients
#3
REVIEW
Haruhiko Terai, Takaaki Ueno, Yoshifumi Suwa, Michi Omori, Kayoko Yamamoto, Shin Kasuya
Although many oral ulcers have similar clinical appearances, their etiologies can range from reactive to neoplastic to oral manifestations of dermatological diseases. In patients with an HIV infection, fungal diseases may cause ulceration in the oral cavity; however, there have been few studies of oral ulcerative lesions associated with Candida in patients without an HIV infection. Nevertheless, we encountered chronic oral ulcer associated with Candida among our frequent outpatients without an HIV infection...
May 2018: Japanese Dental Science Review
https://www.readbyqxmd.com/read/29753928/dynamic-changes-of-th1-th2-th17-cytokines-and-human-beta-defensin-2-in-hiv-infected-patients-with-oral-candidiasis-during-the-first-year-of-highly-active-anti-retroviral-therapy
#4
Xiangzhi Yong, Zhenmin Liu, Lanlan Jiang, Renchuan Tao, Wei Liu, Linlin Zhang, Yuanyuan Peng, Xuefang Lin, Yuxiao Huang
OBJECTIVE: To investigate the change of Th1/Th2/Th17 cytokines and human beta defensin 2 (HBD-2) in HIV-infected patients with oral candidiasis (OC) and gather information about OC-specific immunity. DESIGN: During the 1st year of highly active anti-retroviral therapy (HAART), 25 HIV-infected patients were followed up at the baseline, 3rd, 6th, 12th month. At each visit, oral manifestations were examined; oral rinses were collected and cultured for Candida; peripheral venous blood was taken to determine CD4 + T cell counts and HIV RNA viral load (VL); both unstimulated whole saliva and peripheral venous blood were taken to determine cytokine (IL-4, IL-17(A/F), IFN-γ) and HBD-2 levels...
May 3, 2018: Archives of Oral Biology
https://www.readbyqxmd.com/read/29747810/oral-health-interventions-using-chlorhexidine-effects-on-the-prevalence-of-oral-opportunistic-pathogens-in-stroke-survivors-a-randomized-clinical-trial
#5
Normaliza Ab Malik, Fathilah Abdul Razak, Sa'ari Mohamad Yatim, Otto Lok Tao Lam, Lijian Jin, Leonard S W Li, Colman McGrath
OBJECTIVE: To evaluate the presence of oral opportunistic pathogens among stroke survivors, both before and after oral health care interventions. METHODS: A multicenter randomized clinical trial was conducted on hospitalized stroke survivors. Those in the control group were given standard care of oral hygiene (a manual toothbrush and toothpaste), whereas those in the test group were given intense care of oral hygiene (a powered toothbrush and 1% chlorhexidine oral gel)...
June 2018: Journal of Evidence-based Dental Practice
https://www.readbyqxmd.com/read/29747356/-research-on-the-surgery-treatment-and-etiology-of-fungal-endophthalmitis
#6
H Y Zhou, J J Ye, Y Y Chen, F T Dong
Objective: To evaluate the efficacy of vitrectomy and etiological diagnosis in the treatment of fungal endophthalmitis. Methods: A retrospective survey was done on the clinical manifestation, etiological diagnosis and treatment efficacy of 15 patients (15 eyes) who had been diagnosed with fungal endophthalmitis at the inpatient department of Peking Union Medical College Hospital during 2002-2015. A total of 15 eyes of 15 patients, 3 male and 12 female patients, were included in this study. The mean age of the patients was (45...
April 11, 2018: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29746713/lack-of-impact-by-scy-078-a-first-in-class-oral-fungicidal-glucan-synthase-inhibitor-on-the-pharmacokinetics-of-rosiglitazone-a-substrate-for-cyp450-2c8-supports-the-low-risk-for-clinically-relevant-metabolic-drug-drug-interactions
#7
Stephen Wring, Gail Murphy, George Atiee, Christy Corr, Michele Hyman, Michael Willett, David Angulo
SCY-078, the first in a new class of β 1,3-glucan synthesis inhibitors, is being developed as an oral and intravenous antifungal treatment for Candida and Aspergillus species fungal infections. In vitro, studies indicated SCY-078 is an inhibitor of cytochrome P450 (CYP) 2C8 with markedly lower effect over other CYP isozymes. To examine clinically relevant effects of the potential interaction with SCY-078, this phase 1, open-label, 2-period crossover study evaluated the pharmacokinetic parameters of rosiglitazone, a sensitive substrate of CYP2C8 metabolism, in the absence and presence of SCY-078 dosed to therapeutically relevant SCY-078 concentration exposure after repeat dosing...
May 10, 2018: Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29742274/safety-of-tildrakizumab-for-moderate-to-severe-plaque-psoriasis-pooled-analysis-of-three-randomised-controlled-trials
#8
A Blauvelt, K Reich, K A Papp, A B Kimball, M Gooderham, S K Tyring, R Sinclair, D Thaci, Q Li, N Cichanowitz, S Green, C La Rosa
BACKGROUND: Short-term IL-23p19 inhibition by tildrakizumab improves plaque psoriasis and appears well-tolerated. OBJECTIVES: Safety/tolerability were assessed for up to 64 weeks of tildrakizumab therapy using pooled data from 3 randomised controlled trials for moderate-to-severe psoriasis. METHODS: Data pools for the placebo-controlled (up to 16 weeks) and full-trial periods (up to 64 weeks) were analysed (N=2081). RESULTS: In the placebo-controlled period, frequencies of treatment-emergent adverse events (TEAEs; range=47...
May 9, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29741145/tandem-mass-spectrometric-cell-wall-proteome-profiling-of-a-candida-albicans-hwp2-mutant-strain
#9
Andy Awad, Pamela El Khoury, Brigitte Wex, Roy A Khalaf
BACKGROUND: Candida albicans is present as part of the normal gut flora and detected in the oral cavities and GI tracts of around fifty percent of adults. Benign colonization can turn pathogenic causing a variety of mild to severe infections. In a pathogen, the cell wall and cell surface proteins are major antigenic determinants and drug targets as they are the primary structures that contact the host. Cell surface proteins perform a variety of functions necessary for virulence such as adhesion, host degradation, resistance to oxidative stress, and drug resistance...
May 9, 2018: Current Molecular Pharmacology
https://www.readbyqxmd.com/read/29738262/candida-albicans-release-intracellular-bacteria-when-treated-with-amphotericin-b
#10
Atefeh Tavakolian, Farideh Siavoshi, Fereshteh Eftekhar
BACKGROUND: Coexistence of bacteria and yeast in a myriad of microbial communities is indicative of their intimate relationship, which could be the intracellular existence of bacteria inside yeast. In this study, the intracellular existence of bacteria inside yeast and bacterial release from amphotericin B-treated yeasts was examined using polymerase chain reaction (PCR) and microscopy. METHODS: Released bacteria, B1 from Y1 (a gastric yeast) and B2 from Y2 (an oral yeast) were identified as Staphylococcus hominis and Staphylococcus haemolyticus by biochemical tests as well as amplification of Staph-specific tuf and 16S rRNA genes...
May 1, 2018: Archives of Iranian Medicine
https://www.readbyqxmd.com/read/29737225/esophageal-pyogenic-granuloma-a-case-report-and-review-of-the-literature
#11
David A Suarez-Zamora, Paula A Rodriguez-Urrego, Jaime Solano-Mariño, Fernando Sierra-Arango, Mauricio A Palau-Lazaro
Pyogenic granuloma (PG) is a capillary hemangioma mainly found in the skin and oral mucosa, but rarely described in the esophagus. We report the case of a 66-year-old man who consulted for retrosternal pain. Endoscopic studies showed a 28-mm polypoid mass located at the distal esophageal mucosa. The patient underwent endoscopic resection, and the histopathological examination showed a neoplastic proliferation of small blood vessels growing in a lobular architecture, with edematous stroma and prominent inflammatory infiltrate...
May 1, 2018: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29731575/oral-carriage-of-cariogenic-bacteria-and-candida-albicans-in-asthmatic-adults-before-and-after-anti-asthma-medication-a-longitudinal-study
#12
R B Ashuja, D B Nandini, B Vidyasagar, R Ashwini, Mandana Donoghue, G S Madhushankari
Background: Antiasthmatic medications such as β2 agonists and corticosteroids have shown potential side effects such as increased caries risk and oral candidiasis. Studies evaluating microbial changes in adult asthmatics are very scanty in the literature. The present study aimed to evaluate the effects of asthma and its medication on cariogenic bacteria and Candida albicans in adult asthmatics. Aim and Objectives: Our aim was to evaluate and compare counts of Streptococcus mutans (SM) and lactobacilli in plaque and C...
January 2018: Journal of Oral and Maxillofacial Pathology: JOMFP
https://www.readbyqxmd.com/read/29729384/toxicological-evaluation-and-anti-inflammatory-potential-of-an-ethanolic-extract-from-bromelia-balansae-bromeliaceae-fruit
#13
Paola da Silva Balin, Flavia Carina Zanatta, Bárbara Campos Jorge, Maicon Leitão, Roberto Mikio Kassuya, Claudia Andrea Lima Cardoso, Cândida Aparecida Leite Kassuya, Arielle Cristina Arena
ETHNOPHARMACOLOGICAL RELEVANCE: Bromelia balansae is a relatively unexplored medicinal species that is used for nutritional purposes and in folk medicine to treat cough or wounds. AIM OF THIS STUDY: This study assessed the anti-inflammatory activity of the ethanolic extract obtained from Bromelia balansae fruit (EEBB) as well as the toxicological potential of this extract after single and repeated exposure. MATERIALS AND METHODS: Male rats (Wistar) were gavaged with 2000 mg/kg of extract from the fruit of B...
May 2, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29724862/rapid-phenotypic-and-genotypic-diversification-after-exposure-to-the-oral-host-niche-in-candida-albicans
#14
Anja Forche, Gareth Cromie, Aleeza C Gerstein, Norma V Solis, Tippapha Pisithkul, Waracharee Srifa, Eric Jeffery, Darren Abbey, Scott G Filler, Aimée M Dudley, Judith Berman
In vitro studies suggest that stress may generate random standing variation, and that different cellular and ploidy states may evolve more rapidly under stress. Yet this idea has not been tested with pathogenic fungi growing within their host niche in vivo Here, we analyzed the generation of both genotypic and phenotypic diversity during exposure of Candida albicans to the mouse oral cavity. Ploidy, aneuploidy, loss of heterozygosity (LOH) and recombination were determined using flow cytometry and ddRADseq...
May 3, 2018: Genetics
https://www.readbyqxmd.com/read/29715565/in-vivo-and-in-vitro-activity-of-a-bis-arylidenecyclo-alkanone-against-fluconazole-susceptible-and-resistant-isolates-of-candida-albicans
#15
Nívea Pereira de Sá, Lídia Fátima José de Paula, Larissa Ferreira Finamore Lopes, Lana Ivone Barreto Cruz, Thelma Tirone Silvério Matos, Cleudiomar Inácio Lino, Renata Barbosa de Oliveira, Elaine Maria de Souza-Fagundes, Beth Burgwyn Fuchs, Eleftherios Mylonakis, Susana Johann
OBJECTIVES: Candida albicans is a commensal pathogen associated with both superficial (mucosal and cutaneous) and systemic infections. The extensive use of antifungal agents has led to reduced susceptibility to the few existing drugs. This situation has encouraged the search for novel antifungal agents. Therefore, in the present study, we investigated the antifungal activity of 2,6-bis[(E)-(4-pyridyl)methylidene]cyclohexanone (PMC). METHODS: We evaluated its in vitro activity against C...
April 28, 2018: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/29702448/new-pyrazolopyridine-analogs-synthesis-antimicrobial-antiquorum-sensing-and-antitumor-screening
#16
N S El-Gohary, M I Shaaban
New pyrazolopyridine analogs were prepared and tested for antimicrobial efficacy toward Staphylococcus aureus, Bacillus cereus, Escherichia coli, Pseudomonas aeruginosa, Candida albicans, Aspergillus fumigatus and Aspergillus flavus. Results revealed that compound 6 has prominent and broad spectrum antimicrobial activity. Compound 8 showed good antibacterial efficacy over the four tested bacterial strains. In addition, compounds 2-4 displayed interesting efficacy over S. aureus, B. cereus and P. aeruginosa as well as moderate efficacy toward E...
April 11, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29691333/community-development-between-porphyromonas-gingivalis-and-candida-albicans-mediated-by-inlj-and-als3
#17
Maryta N Sztukowska, Lindsay C Dutton, Christopher Delaney, Mark Ramsdale, Gordon Ramage, Howard F Jenkinson, Angela H Nobbs, Richard J Lamont
The pleiomorphic yeast Candida albicans is a significant pathogen in immunocompromised individuals. In the oral cavity, C. albicans is an inhabitant of polymicrobial communities, and interspecies interactions promote hyphal formation and biofilm formation. C. albicans colonizes the subgingival area, and the frequency of colonization increases in periodontal disease. In this study, we investigated the interactions between C. albicans and the periodontal pathogen Porphyromonas gingivalis C. albicans and P...
April 24, 2018: MBio
https://www.readbyqxmd.com/read/29687060/an-aberrant-reaction-to-candida-albicans-antigen-used-for-recalcitrant-warts-successfully-treated-with-oral-prednisone
#18
Andrew La'Pelusa, Jennifer Rorex, Nathan M Weir, Jeffrey Bryant Travers
No abstract text is available yet for this article.
April 2018: JAAD Case Reports
https://www.readbyqxmd.com/read/29686781/salivary-metals-age-and-gender-correlate-with-cultivable-oral-candida-carriage-levels
#19
Hannah L Norris, Justin Friedman, Ziqiang Chen, Sumant Puri, Gregory Wilding, Mira Edgerton
Background : Little is known about the normal range of metal levels in unstimulated saliva, nor whether these might impact Candida carriage in healthy individuals. Both are important in determining which populations are at risk for candidiasis, as the availability of metal ions can influence the growth and pathogenesis of Candida albicans . Objective : We quantified salivary metals of healthy individuals to determine the correlation with C. albicans oral colonization. Design : Unstimulated whole saliva was collected from healthy adults and plated to determine fungal carriage, and metal content was measured using ICP-mass spectrometry (ICP-MS)...
2018: Journal of Oral Microbiology
https://www.readbyqxmd.com/read/29685324/-green-tongue-phenomenon-or-diagnosis-via-google
#20
C Godillot, A Laprie, C Eid, J-C Fricain, S Boulinguez, E Casassa, E Vigarios, V Sibaud
BACKGROUND: Regular cannabis use may be associated with several oral changes not usually identified by dermatologists: xerostomia, increased risk of caries, periodontitis, leukoedema, gingival hyperplasia, and higher prevalence and density of Candida albicans, leukoplakia or gingivitis. PATIENTS AND METHODS: We report herein the appearance of a characteristic green tongue in a patient following intensive marijuana inhalation. DISCUSSION: This complication has rarely been reported in the medical literature...
April 21, 2018: Annales de Dermatologie et de Vénéréologie
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