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Adult asthma

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https://www.readbyqxmd.com/read/29653218/comparing-ran-out-status-of-inhaled-short-acting-beta-agonists-in-emergency-department-patients-with-acute-asthma-1996-1998-versus-2015-2017
#1
Tadahiro Goto, Carlos A Camargo, Catalina Gimenez-Zapiola, Daniel J Pallin, Nathan I Shapiro, Thomas J Ferro, Carolyn Rainville, Stanislav Stoyanov, Kohei Hasegawa
BACKGROUND: Medication non-adherence including running out of inhaled asthma medications, is an important problem. OBJECTIVE: To examine the changes in the proportion of adults with acute asthma who ran out of their short-acting beta-agonist (SABA) inhalers before presenting to the emergency department (ED) between 1996-1998 and 2015-2017. METHODS: We analyzed data from prospective multicenter observational cohort studies of ED adult patients (aged 18-54 years) with acute asthma...
April 10, 2018: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29652637/asthma-and-allergy-as-risk-factors-for-suicidal-behavior-among-young-adults
#2
Perla A Vargas, Elias Robles-Sotelo
An association between allergic disease, depression and suicidality has been reported. OBJECTIVE: To explore the relationships between suicidality and asthma, allergy, internet addiction, stress, sleep quality, pain/discomfort, and depression, among emerging adults. PARTICIPANTS: 929 college students completed an online survey between October 2015 and April 2017. METHODS: A cross-sectional study using multivariate analysis techniques was implemented...
April 13, 2018: Journal of American College Health: J of ACH
https://www.readbyqxmd.com/read/29644903/patients-with-chronic-rhinosinusitis-and-obstructive-sleep-apnea-have-increased-paroxysmal-limb-movement
#3
Mahboobeh Mahdavinia, Jessica W Hui, Mohamed Zitun, Alejandra Lastra, James J Herdegen, Christopher D Codispoti, Rafsa J Khan, Phillip S LoSavio, Pete S Batra
BACKGROUND: Patients with chronic rhinosinusitis (CRS) frequently experience sleep disruption and are at a higher than normal risk for obstructive sleep apnea (OSA). The purpose of this study was to determine how CRS affects polysomnography findings and sleep-related breathing in OSA. METHODS: A cohort study was performed that included 107 adult patients with CRS and comorbid OSA (CRS+OSA group) and 137 patients with OSA and without CRS as the control group. An electronic medical records database was used to identify eligible subjects...
March 2018: American Journal of Rhinology & Allergy
https://www.readbyqxmd.com/read/29642970/work-aggravated-asthma-in-great-britain-a-cross-sectional-postal-survey
#4
Lisa Bradshaw, Jade Sumner, Julian Delic, Paul Henneberger, David Fishwick
OBJECTIVE: Work aggravated asthma (WAA), asthma made worse by but not caused by workplace exposures, can have a negative impact on personal, social, financial and societal costs. There is limited data on prevalence levels of WAA in Great Britain (GB). The objective of this study was to estimate the prevalence of WAA in GB, and to assess its potential causes.Materials and methodsA cross-sectional postal questionnaire study was carried out. A total of 1620 questionnaires were sent to three populations of adults with asthma...
April 12, 2018: Primary Health Care Research & Development
https://www.readbyqxmd.com/read/29642624/understanding-and-increasing-influenza-vaccination-acceptance-insights-from-a-2016-national-survey-of-u-s-adults
#5
Glen J Nowak, Michael A Cacciatore, María E Len-Ríos
Background : The percentage of adults in the U.S. getting seasonal influenza vaccination has not changed significantly since 2013 and remains far below the federal government's 70% target. Objective : This study assessed and identified characteristics, experiences, and beliefs associated with influenza vaccination using a nationally representative survey of 1005 U.S. adults 19 years old and older. Methods : The sample was drawn from the National Opinion Research Center's AmeriSpeak Panel, a probability-based panel designed to be representative of the U...
April 10, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29629847/understanding-the-cognitive-and-affective-mechanisms-that-underlie-proxy-risk-perceptions-among-caregivers-of-asthmatic-children
#6
James A Shepperd, Nikolette P Lipsey, Thorsten Pachur, Erika A Waters
OBJECTIVE: Medical decisions made on behalf of another person-particularly those made by adult caregivers for their minor children-are often informed by the decision maker's beliefs about the treatment's risks and benefits. However, we know little about the cognitive and affective mechanisms influencing such "proxy" risk perceptions and about how proxy risk perceptions are related to prominent judgment phenomena. METHODS: Adult caregivers of minor children with asthma ( N = 132) completed an online, cross-sectional survey assessing 1) cognitions and affects that form the basis of the availability, representativeness, and affect heuristics; 2) endorsement of the absent-exempt and the better-than-average effect; and 3) proxy perceived risk and unrealistic comparative optimism of an asthma exacerbation...
April 1, 2018: Medical Decision Making: An International Journal of the Society for Medical Decision Making
https://www.readbyqxmd.com/read/29628376/childhood-predictors-of-lung-function-trajectories-and-future-copd-risk-a-prospective-cohort-study-from-the-first-to-the-sixth-decade-of-life
#7
Dinh S Bui, Caroline J Lodge, John A Burgess, Adrian J Lowe, Jennifer Perret, Minh Q Bui, Gayan Bowatte, Lyle Gurrin, David P Johns, Bruce R Thompson, Garun S Hamilton, Peter A Frith, Alan L James, Paul S Thomas, Deborah Jarvis, Cecilie Svanes, Melissa Russell, Stephen C Morrison, Iain Feather, Katrina J Allen, Richard Wood-Baker, John Hopper, Graham G Giles, Michael J Abramson, Eugene H Walters, Melanie C Matheson, Shyamali C Dharmage
BACKGROUND: Lifetime lung function is related to quality of life and longevity. Over the lifespan, individuals follow different lung function trajectories. Identification of these trajectories, their determinants, and outcomes is important, but no study has done this beyond the fourth decade. METHODS: We used six waves of the Tasmanian Longitudinal Health Study (TAHS) to model lung function trajectories measured at 7, 13, 18, 45, 50, and 53 years. We analysed pre-bronchodilator FEV1 z-scores at the six timepoints using group-based trajectory modelling to identify distinct subgroups of individuals whose measurements followed a similar pattern over time...
April 5, 2018: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/29627424/asthma-across-the-lifespan-time-for-a-paradigm-shift
#8
Stanley J Szefler
We have a unique opportunity to significantly reduce the worldwide burden of asthma in children and impact respiratory outcomes in adults. However, this will require a paradigm shift that is directed at altering the natural history of asthma, reducing asthma exacerbations and preventing long-term adverse outcomes of childhood asthma. Attention should continue to be directed toward minimizing risk as well as impairment with a goal to achieve optimal control. Based on several NIH studies conducted over the last 10 years we now have the tools necessary to accomplish this goal...
April 5, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29627041/obesity-and-asthma
#9
REVIEW
Ubong Peters, Anne E Dixon, Erick Forno
Obesity is a vast public health problem and both a major risk factor and disease modifier for asthma in children and adults. Obese subjects have increased asthma risk, and obese asthmatic patients have more symptoms, more frequent and severe exacerbations, reduced response to several asthma medications, and decreased quality of life. Obese asthma is a complex syndrome, including different phenotypes of disease that are just beginning to be understood. We examine the epidemiology and characteristics of this syndrome in children and adults, as well as the changes in lung function seen in each age group...
April 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29625664/challenges-in-the-treatment-of-asthma-in-children-and-adolescents
#10
REVIEW
Stanley J Szefler, Bradley Chipps
OBJECTIVE: Despite the availability of effective treatments, asthma control in children and adolescents remains inadequate and rates of health care use are high. This follow-up to a recent review (O'Byrne et al, Eur Respir J. 2017;50[3]) examines a number of challenges in current pediatric asthma management compared with that of an adult perspective and discusses possible alternative strategies that might improve pediatric asthma management and control. DATA SOURCES: The evidence base for this review is limited because, historically, much of the research has been performed in adults...
April 2018: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/29622380/a-randomized-placebo-controlled-single-ascending-dose-study-to-assess-the-safety-tolerability-pharmacokinetics-and-immunogenicity-of-subcutaneous-tralokinumab-in-japanese-healthy-volunteers
#11
Paul Baverel, Dewei She, Edward Piper, Shinya Ueda, Tomoko Yoshioka, Raffaella Faggioni, Hakop Gevorkyan
Tralokinumab is a human monoclonal antibody in clinical development for asthma and atopic dermatitis that specifically neutralizes interleukin-13. This phase I, single-blind, randomized, placebo-controlled, single ascending-dose study assessed the safety, tolerability, pharmacokinetics (PK), and immunogenicity of subcutaneous tralokinumab (150, 300, or 600 mg) in thirty healthy Japanese adults. The most frequent treatment-emergent adverse event (TEAE) in all treatment groups was injection-site pain. The frequency and severity of TEAEs was similar across tralokinumab doses...
December 12, 2017: Drug Metabolism and Pharmacokinetics
https://www.readbyqxmd.com/read/29621204/prevalence-of-asthma-asthma-attacks-and-emergency-department-visits-for-asthma-among-working-adults-national-health-interview-survey-2011-2016
#12
Jacek M Mazurek, Girija Syamlal
In 2010, an estimated 8.2% of U.S. adults had current asthma, and among these persons, 49.1% had had an asthma attack during the past year (1). Workplace exposures can cause asthma in a previously healthy worker or can trigger asthma exacerbations in workers with current asthma* (2). To assess the industry- and occupation-specific prevalence of current asthma, asthma attacks, and asthma-related emergency department (ED) visits among working adults, CDC analyzed 2011-2016 National Health Interview Survey (NHIS) data for participants aged ≥18 years who, at the time of the survey, were employed at some time during the 12 months preceding the interview...
April 6, 2018: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/29618952/role-of-genetic-variations-of-chitinase-3-like-1-in-bronchial-asthmatic-patients
#13
Kazuyuki Abe, Yutaka Nakamura, Kohei Yamauchi, Makoto Maemondo
Background: Single nucleotide polymorphisms (SNPs) in chitinase 3 - like 1 ( CHI3L1 ) are associated with bronchial severity and pulmonary function. CHI3L1 proteins are involved in both innate and adaptive immune responses; however, to date, the correlation of these SNPs and their age of onset of bronchial asthma has not been demonstrated. Methods: To address the role of these genetic variations, 390 patients with well-controlled bronchial asthma and living in Japan were recruited, genotyped, and had a pulmonary function test performed on them in this study...
2018: Clinical and Molecular Allergy: CMA
https://www.readbyqxmd.com/read/29618600/outdoor-air-pollution-exhaled-8-isoprostane-and-current-asthma-in-adults-the-egea-study
#14
Anaïs Havet, Farid Zerimech, Margaux Sanchez, Valérie Siroux, Nicole Le Moual, Bert Brunekreef, Morgane Stempfelet, Nino Künzli, Bénédicte Jacquemin, Régis Matran, Rachel Nadif
Associations between outdoor air pollution and asthma in adults are still scarce, and the underlying biological mechanisms are poorly understood. Our aim was to study the associations between 1) long-term exposure to outdoor air pollution and current asthma, 2) exhaled 8-isoprostane (8-iso; a biomarker related to oxidative stress) and current asthma, and 3) outdoor air pollution and exhaled 8-iso.Cross-sectional analyses were conducted in 608 adults (39% with current asthma) from the first follow-up of the French case-control and family study on asthma (EGEA; the Epidemiological study of the Genetic and Environmental factors of Asthma)...
April 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29617182/-%C3%A2-i-ve-said-i-wish-i-was-dead-you-d-be-better-off-without-me-a-systematic-review-of-people-s-experiences-of-living-with-severe-asthma
#15
Daniela Eassey, Helen K Reddel, Juliet M Foster, Susan Kirkpatrick, Louise Locock, Kath Ryan, Lorraine Smith
OBJECTIVE: Our aim was to conduct a systematic review and synthesis of qualitative evidence exploring the lived experience of adults with severe asthma. DATA SOURCES: We searched MEDLINE via OvidSP, PsycINFO via OvidSP, PubMed, CINAHL, EMBASE, Sociological Abstracts, Google Scholar, the journals Qualitative Health Research and Qualitative Research, and a study of experiences of living with asthma by the Health Experiences Research group. STUDY SELECTIONS: Studies were included if they used qualitative methods and explored the subjective experiences of adults (≥18 years) with a clear diagnosis of severe asthma...
April 4, 2018: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29611863/-when-and-how-to-step-down-asthma-treatment
#16
Lars Ahlbeck, Björn Stridh, Björn Ställberg, Hampus Kiotseridis, Christer Janson, Kerstin Romberg
Swedish asthma guidelines recommend treating asthma with the lowest effective dose possible. These recommendations are both hard to follow and seldom considered enough in asthma care today. As an example, combination therapy with inhaled corticosteroids (ICS) and long acting beta agonists (LABA) should only be considered if asthma control is not achieved with low to medium dose ICS daily. However, the Swedish National Board of Health and Welfare estimates that 120 000 asthma patients are overmedicated with combination therapy...
March 27, 2018: Läkartidningen
https://www.readbyqxmd.com/read/29611776/last-station-in-the-eosinophilic-asthma-with-chronic-rhinosinusitis-and-or-nasal-polyposis-march-eosinophilic-asthma-with-radiological-findings-associated-with-blood-eosinophilia
#17
Insu Yılmaz, Sakine Nazik Bahçecioğlu, Murat Türk, Nuri Tutar, Fatma Sema Oymak, İnci Gülmez
OBJECTIVE: Eosinophilic asthma with chronic rhinosinusitis and/or nasal polyposis (EA-CRS/NP) is a subphenotype of adult-onset eosinophilic asthma. Blood eosinophil levels are shown to be highly elevated in patients with EA-CRS/NP and have potential for tissue infiltration. We aimed to demonstrate the clinical features of the patients who have a blood eosinophil level above 10% and have thorax computed tomography findings due to blood eosinophilia. METHODS: Patients who were followed up in our clinic between 2012 and 2017 were retrospectively evaluated...
April 3, 2018: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29609049/type-2-biomarkers-and-prediction-of-future-exacerbations-and-lung-function-decline-in-adult-asthma
#18
Ruth Semprini, Mathew Williams, Alex Semprini, Alice McDouall, James Fingleton, Cecile Holweg, Mark Weatherall, Richard Beasley, Irene Braithwaite
BACKGROUND: Type 2 biomarkers that predict both likelihood of future severe exacerbations and response to monoclonal antibody therapy in asthma, would be useful clinically in identifying patients both at greater risk of hospitalization, and most likely to benefit from monoclonal antibody therapy. OBJECTIVE: To describe the association between the Type 2 biomarkers, blood eosinophils, FeNO, serum periostin, serum IgE and time to severe exacerbation in a broad asthma population...
March 30, 2018: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29605216/inhaled-corticosteroids-and-asthma-control-in-adult-onset-asthma-12-year-follow-up-study
#19
Iida Vähätalo, Pinja Ilmarinen, Leena E Tuomisto, Onni Niemelä, Hannu Kankaanranta
BACKGROUND: Prescribed inhaled corticosteroid (ICS) doses in asthma have been studied in cross-sectional settings whereas long-term follow-up studies have not been carried out. OBJECTIVE: To evaluate prescribed medication longitudinally by calculating cumulative ICS doses and dose changes in a cohort of new-onset adult asthma during 12 years and in different groups of asthma control. METHODS: A total of 203 patients were followed for 12 years as part of Seinäjoki Adult Asthma Study (SAAS)...
April 2018: Respiratory Medicine
https://www.readbyqxmd.com/read/29605212/prevalence-and-risk-factors-of-asthma-in-mainland-china-the-care-study
#20
Jiangtao Lin, Wenya Wang, Ping Chen, Xin Zhou, Huanying Wan, Kaisheng Yin, Lijun Ma, Changgui Wu, Jing Li, Chuntao Liu, Nan Su, Guoliang Liu, Hua Xie, Wei Tang, Mao Huang, Yan Chen, Yuanhua Liu, Liqiang Song, Xianliang Chen, Yongming Zhang, Wen Li, Lichao Sun
BACKGROUND: There are limited population based data on the prevalence of asthma in China. The China Asthma and Risk factors Epidemiologic (CARE) survey was designed to understand the prevalence and risk factors for asthma in mainland China. OBJECTIVES: The CARE survey aims to demonstrate the prevalence and risk factors of asthma in mainland China among adolescents (age >14 years) and adults. METHODS: The survey was performed between February 2010 and August 2012 in eight provinces/cities of seven areas in mainland China...
April 2018: Respiratory Medicine
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