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https://www.readbyqxmd.com/read/28077477/the-global-asthma-network-rationale-and-methods-for-phase-i-global-surveillance-prevalence-severity-management-and-risk-factors
#1
Philippa Ellwood, M Innes Asher, Nils E Billo, Karen Bissell, Chen-Yuan Chiang, Eamon M Ellwood, Asma El-Sony, Luis García-Marcos, Javier Mallol, Guy B Marks, Neil E Pearce, David P Strachan
The Global Asthma Network (GAN), established in 2012, followed the International Study of Asthma and Allergies in Childhood (ISAAC). ISAAC Phase One involved over 700 000 adolescents and children from 156 centres in 56 countries; it found marked worldwide variation in symptom prevalence of asthma, rhinitis and eczema that was not explained by the current understanding of these diseases; ISAAC Phase Three involved over 1 187 496 adolescents and children (237 centres in 98 countries). It found that asthma symptom prevalence was increasing in many locations especially in low- and middle-income countries where severity was also high, and identified several environmental factors that required further investigation...
January 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28076656/combined-inhaled-beta-agonist-and-anticholinergic-agents-for-emergency-management-in-adults-with-asthma
#2
REVIEW
Scott W Kirkland, Christine Vandenberghe, Britt Voaklander, Taylor Nikel, Sandra Campbell, Brian H Rowe
BACKGROUND: Inhaled short-acting anticholinergics (SAAC) and short-acting beta₂-agonists (SABA) are effective therapies for adult patients with acute asthma who present to the emergency department (ED). It is unclear, however, whether the combination of SAAC and SABA treatment is more effective in reducing hospitalisations compared to treatment with SABA alone. OBJECTIVES: To conduct an up-to-date systematic search and meta-analysis on the effectiveness of combined inhaled therapy (SAAC + SABA agents) vs...
January 11, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28076614/association-between-asthma-and-female-sex-hormones
#3
Raquel Prudente de Carvalho Baldaçara, Ivaldo Silva
CONTEXT AND OBJECTIVE: The relationship between sex hormones and asthma has been evaluated in several studies. The aim of this review article was to investigate the association between asthma and female sex hormones, under different conditions (premenstrual asthma, use of oral contraceptives, menopause, hormone replacement therapy and pregnancy). DESIGN AND SETTING: Narrative review of the medical literature, Universidade Federal do Tocantins (UFT) and Universidade Federal de São Paulo (Unifesp)...
January 5, 2017: São Paulo Medical Journal, Revista Paulista de Medicina
https://www.readbyqxmd.com/read/28076315/meteorological-parameters-and-pollutants-on-asthma-exacerbation-in-bangalore-india-an-ecological-retrospective-time-series-study
#4
Kirthana U Kunikullaya, Ambarish Vijayaraghava, P Asha, Radhika Kunnavil, B V MuraliMohan
BACKGROUND: Literature has shown a significant association between asthma exacerbations and pollutant levels during that time. There is very limited evidence in India, especially Bangalore, for impacts of meteorological changes and pollution on asthma hospital admissions in adults. The objective was to study the impact of air pollution and meteorological parameters on asthma exacerbation in Bangalore. METHODS: This study quantitatively analyzed the relation between acute exacerbations of asthma and related admissions to the hospital with the air pollution and the meteorological conditions during that time...
January 11, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/28075383/soluble-fibre-meal-challenge-reduces-airway-inflammation-and-expression-of-gpr43-and-gpr41-in-asthma
#5
Isabel Halnes, Katherine J Baines, Bronwyn S Berthon, Lesley K MacDonald-Wicks, Peter G Gibson, Lisa G Wood
Short chain fatty acids (SCFAs) are produced following the fermentation of soluble fibre by gut bacteria. In animal models, both dietary fibre and SCFAs have demonstrated anti-inflammatory effects via the activation of free fatty acid receptors, such as G protein-coupled receptor 41 and 43 (GPR41 and GPR43). This pilot study examined the acute effect of a single dose of soluble fibre on airway inflammation-including changes in gene expression of free fatty acid receptors-in asthma. Adults with stable asthma consumed a soluble fibre meal (n = 17) containing 3...
January 10, 2017: Nutrients
https://www.readbyqxmd.com/read/28074763/-dysfunctional-breathing-in-patients-with-asthma
#6
Karen Hjerrild Andreasson, Søren T Skou, Celeste Porsbjerg, Sandra Veidal, Uffe Bødtger
Dysfunctional breathing (DB) is a common comorbidity in adults with incomplete asthma control. The few available large-scale, randomized studies suggest efficacy of physiotherapy on symptom burden. In this article we discuss the current evidence including the need for systematic description of physiotherapeutic interventions. We also describe how access to physiotherapy service for DB (with or without asthma) is highly heterogeneous in Denmark, and that there is a need for increasing awareness of physiotherapy implementation for and research in DB (with or without concomitant asthma)...
January 9, 2017: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/28069845/at-federally-funded-health-centers-medicaid-expansion-was-associated-with-improved-quality-of-care
#7
Megan B Cole, Omar Galárraga, Ira B Wilson, Brad Wright, Amal N Trivedi
In 2014 many uninsured, low-income nonelderly adults gained access to health insurance in states that expanded Medicaid eligibility under the Affordable Care Act. Federally funded community health centers were likely to be particularly affected by this expansion because many of their patients were uninsured and low income. We used a difference-in-differences approach to compare changes among 1,057 such centers in expansion versus nonexpansion states from 2011 to 2014, in terms of their patients' insurance coverage, the number of patients they served, and the quality of care they provided...
January 1, 2017: Health Affairs
https://www.readbyqxmd.com/read/28067830/bronchopulmonary-dysplasia-chronic-lung-disease-of-infancy-and-long-term-pulmonary-outcomes
#8
REVIEW
Lauren M Davidson, Sara K Berkelhamer
Bronchopulmonary dysplasia (BPD) is a chronic lung disease most commonly seen in premature infants who required mechanical ventilation and oxygen therapy for acute respiratory distress. While advances in neonatal care have resulted in improved survival rates of premature infants, limited progress has been made in reducing rates of BPD. Lack of progress may in part be attributed to the limited therapeutic options available for prevention and treatment of BPD. Several lung-protective strategies have been shown to reduce risks, including use of non-invasive support, as well as early extubation and volume ventilation when intubation is required...
January 6, 2017: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/28065772/multimorbidity-in-middle-aged-adults-with-cerebral-palsy
#9
Nicole Cremer, Edward A Hurvitz, Mark D Peterson
BACKGROUND: Individuals with cerebral palsy have less lean body mass, greater relative adiposity, and lower fitness and physical activity participation; and yet, the prevalence of age-related multimorbidity in this population has yet to be established. PURPOSE: To examine the prevalence of lifestyle-related chronic conditions and multimorbidity in a sample of middle-aged adults with cerebral palsy. METHODS: A clinic-based sample of middle-aged adults with cerebral palsy was examined using Electronic Medical Records Search Engine (EMERSE) software...
January 5, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/28065689/virtual-teach-to-goal%C3%A2-adaptive-learning-of-inhaler-technique-for-inpatients-with-asthma-or-copd
#10
Valerie G Press, Colleen A Kelly, John J Kim, Steven R White, David O Meltzer, Vineet M Arora
BACKGROUND: Asthma and chronic obstructive pulmonary disease (COPD) result in more than 1 million hospitalizations annually. Most hospitalized patients misuse respiratory inhalers. This misuse can be corrected with in-person education; however, this strategy is resource intensive and skills wane quickly after discharge. OBJECTIVE: The objective of this study was to develop and pilot a virtual teach-to-goal™ (V-TTG™) inhaler skill training module, using innovative adaptive learning technology...
January 5, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28063655/analysis-of-home-dust-for-staphylococcus-aureus-and-staphylococcal-enterotoxin-genes-using-quantitative-pcr
#11
Shanna Ludwig, Isabel Jimenez-Bush, Emily Brigham, Sonali Bose, Gregory Diette, Meredith C McCormack, Elizabeth C Matsui, Meghan F Davis
BACKGROUND: The bacterium Staphylococcus aureus (SA) is known to induce allergic inflammatory responses, including through secreted staphylococcal enterotoxin (SE) superantigens. To quantify indoor environmental exposures to these potential allergens, which may be associated with worse asthma, we developed a method for the assessment of S. aureus and SE in home dust and applied it to a study of homes of inner-city adults with asthma. METHODS: We conducted laboratory experiments to optimize sample processing and real-time PCR methods for detection and quantification of SA (femB) and SEA-D, based on published primers...
January 4, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28057889/association-between-il-13-1923c-t-polymorphism-and-asthma-risk-a-meta-analysis-based-on-26-case-control-studies
#12
Yueli Xu, Junjuan Li, Zhaolei Ding, Juan Li, Bin Li, Zhengang Yu, Wei Tan
Asthma is a serious and hereditary respiratory disorder affecting all age groups. Interleukin (IL)-13 is a central regulator of allergic inflammation. The purpose of this study was to estimate the relationship between IL-13 +1923C/T polymorphism and asthma susceptibility. Relevant case-control studies published between January 2000 and July 2016 were searched in the online databases. Review Manage (RevMan) 5.3 was used to conduct the statistical analysis. The pooled odds ratio (OR) with its 95% confidence interval (CI) was employed to calculate the strength of association...
January 5, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/28056050/a-latent-class-analysis-of-multimorbidity-and-the-relationship-to-socio-demographic-factors-and-health-related-quality-of-life-a-national-population-based-study-of-162-283-danish-adults
#13
Finn Breinholt Larsen, Marie Hauge Pedersen, Karina Friis, Charlotte Glümer, Mathias Lasgaard
OBJECTIVES: To identify patterns of multimorbidity in the general population and examine how these patterns are related to socio-demographic factors and health-related quality of life. STUDY DESIGN AND SETTING: We used latent class analysis to identify subgroups with statistically distinct and clinically meaningful disease patterns in a nationally representative sample of Danish adults (N = 162,283) aged 16+ years. The analysis was based on 15 chronic diseases. RESULTS: Seven classes with different disease patterns were identified: a class with no or only a single chronic condition (59% of the population) labeled "1) Relatively Healthy" and six classes with a very high prevalence of multimorbidity labeled; "2) Hypertension" (14%); "3) Musculoskeletal Disorders" (10%); "4) Headache-Mental Disorders" (7%); "5) Asthma-Allergy" (6%); "6) Complex Cardiometabolic Disorders" (3%); and "7) Complex Respiratory Disorders" (2%)...
2017: PloS One
https://www.readbyqxmd.com/read/28055276/quality-of-life-of-asthmatic-children-and-adolescents-portuguese-translation-adaptation-and-validation-of-the-questionnaire-pediatric-quality-of-life-pedsql-asthma-module
#14
Fernanda Pereira Monteiro, Dirceu Solé, Gustavo Falbo Wandalsen
OBJECTIVE: To translate, validate and verify the psychometric properties of the Portuguese version of the instrument "Pediatric Quality of Life Asthma Module" (PedsQL Asthma) culturally adapted for the Brazilian culture. METHODS: After being translated to Portuguese and culturally adapted, the questionnaire was answered by 200 asthmatic children and adolescents (ages 2 to 18) as well as the adults responsible for them. Validation required the use of the following instruments, PedsQL Asthma Children (applied to children and adolescents), PedsQL Asthma Parents (applied to adults responsible for children and adolescents), Pediatric Asthma Quality of Life (PAQLQ), Asthma Control Test (ACT) or Childhood Asthma Control Test (C-ACT), as well as socio-economic and personal information questionnaires...
January 5, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28055002/identifying-possible-asthma-copd-overlap-syndrome-in-patients-with-a-new-diagnosis-of-copd-in-primary-care
#15
Camilla Boslev Baarnes, Peter Kjeldgaard, Mia Nielsen, Marc Miravitlles, Charlotte Suppli Ulrik
The asthma-chronic obstructive pulmonary disease (COPD) overlap syndrome (ACOS) remains poorly characterised. Our aim was to describe an algorithm for identifying possible ACOS in adults with newly diagnosed COPD in primary care. General practitioners (n=241) consecutively recruited subjects ⩾35 years, with tobacco exposure, at least one respiratory symptom and no previous diagnosis of obstructive lung disease. Possible ACOS was defined as chronic airflow obstruction, i.e., post-bronchodilator (BD) forced expiratory volume 1/forced vital capacity (FEV1/FVC) ratio<0...
January 5, 2017: NPJ Primary Care Respiratory Medicine
https://www.readbyqxmd.com/read/28055000/personalising-care-of-adults-with-asthma-from-asia-a-modified-e-dephi-consensus-study-to-inform-management-tailored-to-attitude-and-control-profiles
#16
Alison Chisholm, David B Price, Hilary Pinnock, Tan Tze Lee, Camilo Roa, Sang-Heon Cho, Aileen David-Wang, Gary Wong, Thys van der Molen, Dermot Ryan, Nina Castillo-Carandang, Yee Vern Yong
REALISE Asia-an online questionnaire-based study of Asian asthma patients-identified five patient clusters defined in terms of their control status and attitude towards their asthma (categorised as: 'Well-adjusted and at least partly controlled'; 'In denial about symptoms'; 'Tolerating with poor control'; 'Adrift and poorly controlled'; 'Worried with multiple symptoms'). We developed consensus recommendations for tailoring management of these attitudinal-control clusters. An expert panel undertook a three-round electronic Delphi (e-Delphi): Round 1: panellists received descriptions of the attitudinal-control clusters and provided free text recommendations for their assessment and management...
January 5, 2017: NPJ Primary Care Respiratory Medicine
https://www.readbyqxmd.com/read/28045458/bacteria-isolated-from-lung-modulate-asthma-susceptibility-in-mice
#17
Aude Remot, Delphyne Descamps, Marie-Louise Noordine, Abdelhak Boukadiri, Elliot Mathieu, Véronique Robert, Sabine Riffault, Bart Lambrecht, Philippe Langella, Hamida Hammad, Muriel Thomas
Asthma is a chronic, non-curable, multifactorial disease with increasing incidence in industrial countries. This study evaluates the direct contribution of lung microbial components in allergic asthma in mice. Germ-Free and Specific-Pathogen-Free mice display similar susceptibilities to House Dust Mice-induced allergic asthma, indicating that the absence of bacteria confers no protection or increased risk to aeroallergens. In early life, allergic asthma changes the pattern of lung microbiota, and lung bacteria reciprocally modulate aeroallergen responsiveness...
January 3, 2017: ISME Journal
https://www.readbyqxmd.com/read/28045096/diabetes-cardiac-disorders-and-asthma-as-risk-factors-for-severe-organ-involvement-among-adult-dengue-patients-a-matched-case-control-study
#18
Junxiong Pang, Jung Pu Hsu, Tsin Wen Yeo, Yee Sin Leo, David C Lye
Progression to severe organ involvement due to dengue infection has been associated with severe dengue disease, intensive care treatment, and mortality. However, there is a lack of understanding of the impact of pre-existing comorbidities and other risk factors of severe organ involvement among dengue adults. The aim of this retrospective case-control study is to characterize and identify risk factors that predispose dengue adults at risk of progression with severe organ involvement. This study involved 174 dengue patients who had progressed with severe organ involvement and 865 dengue patients without severe organ involvement, matched by the year of presentation of the cases, who were admitted to Tan Tock Seng Hospital between year 2005 and 2008...
January 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28042927/obstructive-sleep-apnea-and-asthma
#19
Megat Razeem Abdul Razak, Naricha Chirakalwasan
Both asthma and obstructive sleep apnea (OSA) are common conditions involving the adults and children population, and have significant impact on the healthcare system. For the last few decades a lot of data emerged in terms of the prevalence between asthma and OSA. The prevalence ranges from 38% up to as high as 70%. Based on the current concepts of bidirectional relationship of OSA and asthma, it is sensible to assume that treating one disorder will result in the other's better control and vice versa. This review will look into the pathogenesis of concomitant OSA and asthma and whether the first line OSA therapy will result in better control of asthma in patients with concomitant OSA...
December 2016: Asian Pacific Journal of Allergy and Immunology
https://www.readbyqxmd.com/read/28040620/the-long-term-health-impacts-of-medicaid-and-chip
#20
Owen Thompson
This paper estimates the effect of US public health insurance programs for children on health. Previous work in this area has typically focused on the relationship between current program eligibility and current health. But because health is a stock variable which reflects the cumulative influence of health inputs, it would be preferable to estimate the impact of total program eligibility during childhood on longer-term health outcomes. I provide such estimates by using longitudinal data to construct Medicaid and CHIP eligibility measures that are observed from birth through age 18 and estimating the effect of cumulative program exposure on a variety of health outcomes observed in early adulthood...
December 23, 2016: Journal of Health Economics
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