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Cerebral amyloid angiography

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https://www.readbyqxmd.com/read/27497483/cerebral-arterial-occlusion-did-not-promote-the-prevalence-of-cerebral-amyloid-angiopathy
#1
Kazuhiro Honda
BACKGROUND: An impairment of amyloid-β (Aβ) clearance has been suggested in Alzheimer's disease. Perivascular drainage along cerebrovascular vessels is considered an important amyloid clearance pathway. OBJECTIVE: This study examined the effect of reduced arterial pulsation that could cause an impairment in cerebral amyloid drainage on the prevalence of cortical microbleeds (CMBs), a surrogate marker for cerebral amyloid angiopathy (CAA). METHODS: Patients who lost depiction of either side of the carotid artery or the middle cerebral artery on magnetic resonance angiography were studied...
August 1, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27356733/an-autopsy-case-of-superficial-siderosis-of-the-central-nervous-system-accompanied-by-anterior-sacral-polycystic-meningocele-in-neurofibromatosis-type-1
#2
Arifumi Matsumoto, Hiroyoshi Suzuki, Muneshige Tobita, Kinya Hisanaga
A 74-year-old female patient, who was diagnosed with neurofibromatosis type 1 (NF1) at the age of 40, was admitted with complaints of flickering vision and gait disturbance for the last 2 years. On admission, neurological examination revealed mild bilateral hearing loss and ataxia in the limb and trunk. Laboratory tests revealed anti-hepatitis C virus (HCV) antibody positivity and elevated HCV RNA by real-time polymerase chain reaction. The cerebrospinal fluid examination revealed a slightly yellowish appearance with elevated total protein levels...
July 28, 2016: Rinshō Shinkeigaku, Clinical Neurology
https://www.readbyqxmd.com/read/26778730/spontaneous-convexity-subarachnoid-haemorrhage-clinical-series-of-3-patients-with-associated-cerebral-amyloid-angiopathy
#3
D A García Estévez, R M García-Dorrego, B Nieto-Baltar, M Marey-Garrido, T Hierro-Torner
INTRODUCTION: Convexity subarachnoid haemorrhage (cSAH) is a rare type of spontaneous, non-traumatic, and nonaneurysmal SAH characterised by blood collections in one or more cortical sulci in the convexity of the brain; the aetiology varies. We report a clinical case series of 3 patients with cSAH associated with probable cerebral amyloid angiopathy (CAA) who presented with focal sensory seizures and responded well to corticosteroid treatment. PATIENTS: Case 1 was a 67-year-old man reporting right-sided paroxysmal sensory episodes with Jacksonian progression, cheiro-oral symptoms, and motor dysphasia...
January 6, 2016: Neurología: Publicación Oficial de la Sociedad Española de Neurología
https://www.readbyqxmd.com/read/26705433/cerebral-amyloid-angiopathy-with-atypical-imagingfindings-of-subarachnoid-hemorrhage
#4
Akira Tempaku, Hidetoshi Ikeda, Kazumi Nitta
Cerebral amyloid angiopathy (CAA) is observed in most cases of nonhypertensive subcortical hemorrhage involving elderly patients. We herein describe the case of a female in whom a convexal subarachnoid hemorrhage was observed at 55 years of age. The cerebral hemorrhage occurred repeatedly; however, no obvious vascular lesions were observed on a cerebral angiography, and no signs of microbleeding or lesions in the deep white matter were identified on magnetic resonance imaging (MRI). Partial excision of the right frontal cortex and hematoma evacuation were performed, and histopathological examination showed deposition of an acidophilic substance with positive staining for Direct Fast Scarlet (DFS) in the cerebral vascular wall...
2015: Journal of Rural Medicine: JRM
https://www.readbyqxmd.com/read/26113079/three-dimensional-observation-of-virchow-robin-spaces-in-the-basal-ganglia-and-white-matter-and-their-relevance-to-idiopathic-normal-pressure-hydrocephalus
#5
Masatsune Ishikawa, Shigeki Yamada, Kazuo Yamamoto
BACKGROUND: Virchow-Robin spaces (VRS) are brain perivascular spaces containing perforating arteries. Although enlarged VRS are associated with various disorders such as Alzheimer's disease, cerebrovascular disease, and head trauma, their functional role remains unclear. Using highly fluid-sensitive magnetic resonance imaging (MRI) sequences, fine morphological features of VRS and their relevance to idiopathic normal pressure hydrocephalus (iNPH) were investigated. METHODS: Three-dimensional constructive interference in steady state (3D-CISS) on 3 Tesla MRI was applied to 29 individuals...
2015: Fluids and Barriers of the CNS
https://www.readbyqxmd.com/read/26104027/partial-enos-deficiency-causes-spontaneous-thrombotic-cerebral-infarction-amyloid-angiopathy-and-cognitive-impairment
#6
Xing-Lin Tan, Yue-Qiang Xue, Tao Ma, Xiaofang Wang, Jing Jing Li, Lubin Lan, Kafait U Malik, Michael P McDonald, Alejandro M Dopico, Francesca-Fang Liao
BACKGROUND: Cerebral infarction due to thrombosis leads to the most common type of stroke and a likely cause of age-related cognitive decline and dementia. Endothelial nitric oxide synthase (eNOS) generates NO, which plays a crucial role in maintaining vascular function and exerting an antithrombotic action. Reduced eNOS expression and eNOS polymorphisms have been associated with stroke and Alzheimer's disease (AD), the most common type of dementia associated with neurovascular dysfunction...
2015: Molecular Neurodegeneration
https://www.readbyqxmd.com/read/26088185/intracranial-cerebral-artery-dissection-of-anterior-circulation-as-a-cause-of-convexity-subarachnoid-hemorrhage
#7
Kazuki Fukuma, Masafumi Ihara, Tomotaka Tanaka, Yoshiaki Morita, Kazunori Toyoda, Kazuyuki Nagatsuka
BACKGROUND: Convexity subarachnoid hemorrhage (cSAH), defined as intrasulcal bleeding restricted to hemispheric convexities, has several etiologies: reversible cerebral vasoconstriction syndrome, cerebral amyloid angiopathy, and internal carotid artery (ICA) stenosis or occlusion. However, it remains unknown whether cerebral artery dissection causes cSAH. METHODS: We retrospectively investigated patients admitted to our hospital between 2005 and 2013 with ischemic stroke or transient ischemic attack caused by cerebral artery dissection...
2015: Cerebrovascular Diseases
https://www.readbyqxmd.com/read/26020379/an-update-of-the-mayo-clinic-cohort-of-patients-with-adult-primary-central-nervous-system-vasculitis-description-of-163-patients
#8
Carlo Salvarani, Robert D Brown, Teresa Christianson, Dylan V Miller, Caterina Giannini, John Huston, Gene G Hunder
Primary central nervous system vasculitis (PCNSV) is an uncommon condition in which lesions are limited to vessels of the brain and spinal cord. Because the clinical manifestations are not specific, the diagnosis is often difficult, and permanent disability and death are frequent outcomes. This study is based on a cohort of 163 consecutive patients with PCNSV who were examined at the Mayo Clinic over a 29-year period from 1983 to 2011. The aim of the study was to define the characteristics of these patients, which represents the largest series in adults reported to date...
May 2015: Medicine (Baltimore)
https://www.readbyqxmd.com/read/25953372/contribution-of-convexal-subarachnoid-hemorrhage-to-disease-progression-in-cerebral-amyloid-angiopathy
#9
Markus Beitzke, Christian Enzinger, Gerit Wünsch, Martin Asslaber, Thomas Gattringer, Franz Fazekas
BACKGROUND AND PURPOSE: Cerebral amyloid angiopathy-related cortical superficial siderosis (cSS) seems to indicate an increased risk of subsequent intracerebral hemorrhage (ICH). We wanted to identify the mechanisms and sequence of hemorrhagic events which are responsible for this association. METHODS: During a 9-year-period, we identified patients with spontaneous convexal subarachnoid hemorrhage (cSAH) and performed a careful longitudinal analysis of clinical and neuroimaging data...
June 2015: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/25908461/white-matter-perivascular-spaces-on-magnetic-resonance-imaging-marker-of-cerebrovascular-amyloid-burden
#10
Andreas Charidimou, Young T Hong, Hans R Jäger, Zoe Fox, Franklin I Aigbirhio, Tim D Fryer, David K Menon, Elizabeth A Warburton, David J Werring, Jean-Claude Baron
BACKGROUND AND PURPOSE: We investigated the relationship between magnetic resonance imaging-visible centrum semiovale perivascular spaces (CSO-PVS), a biomarker of impaired interstitial fluid drainage, and positron emission tomography-based amyloid-β burden across a wide range of cerebrovascular amyloid deposition. METHODS: Thirty-one nondemented subjects (11 probable cerebral amyloid angiopathy patients and 10 healthy subjects≥60 years; 10 older individuals, <60 years) had brain magnetic resonance imaging and Pittsburgh compound B-positron emission tomography...
June 2015: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/25860345/clinical-spectrum-underlying-etiologies-and-radiological-characteristics-of-cortical-superficial-siderosis
#11
Nina Lummel, Frank Arne Wollenweber, Philippe Demaerel, Katja Bochmann, Rainer Malik, Christian Opherk, Jennifer Linn
Cortical superficial siderosis (cSS) is an increasingly recognized MR-imaging marker most probably caused by focal convexity subarachnoid hemorrhage (SAH). There is accumulating evidence that cSS represents an important risk factor for subsequent intracranial hemorrhages. Here, we aimed to determine clinical symptoms, underlying etiologies, and radiological characteristics of cSS in a large patient cohort. We performed an electronic database search on all patients who presented between 2002 and 2013 to the university hospital Munich with non-traumatic and non-aneurysmal cSS...
June 2015: Journal of Neurology
https://www.readbyqxmd.com/read/25849581/quantitative-amyloid-imaging-using-image-derived-arterial-input-function
#12
Yi Su, Tyler M Blazey, Abraham Z Snyder, Marcus E Raichle, Russ C Hornbeck, Patricia Aldea, John C Morris, Tammie L S Benzinger
Amyloid PET imaging is an indispensable tool widely used in the investigation, diagnosis and monitoring of Alzheimer's disease (AD). Currently, a reference region based approach is used as the mainstream quantification technique for amyloid imaging. This approach assumes the reference region is amyloid free and has the same tracer influx and washout kinetics as the regions of interest. However, this assumption may not always be valid. The goal of this work is to evaluate an amyloid imaging quantification technique that uses arterial region of interest as the reference to avoid potential bias caused by specific binding in the reference region...
2015: PloS One
https://www.readbyqxmd.com/read/25735919/cerebral-amyloid-angiopathy-related-atraumatic-convexal-subarachnoid-hemorrhage-an-aria-before-the-tsunami
#13
MULTICENTER STUDY
Eva Martínez-Lizana, María Carmona-Iragui, Daniel Alcolea, Manuel Gómez-Choco, Eduard Vilaplana, María B Sánchez-Saudinós, Jordi Clarimón, Mar Hernández-Guillamon, Josep Munuera, Ellen Gelpi, Beatriz Gómez-Anson, Manel de Juan-Delago, Raquel Delgado-Mederos, Joan Montaner, Angel Ois, Sergi Amaro, Rafael Blesa, Joan Martí-Fàbregas, Alberto Lleó, Juan Fortea
Atraumatic convexal subarachnoid hemorrhage (cSAH) in elderly patients is a rare entity that has been associated with cerebral amyloid angiopathy (CAA) and intracerebral hematomas (ICH). To characterize this entity and to study these associations, 22 patients over 60 with cSAH were included in a multicenter ambispective cohort study. Clinical data, magnetic resonance imaging (MRI) studies, APOE genotyping, and cerebrospinal fluid (CSF) biomarkers were evaluated. Results were compared with data from healthy controls (HC), non-cSAH CAA patients (CAAo), and Alzheimer disease patients...
May 2015: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/25708615/adult-primary-central-nervous-system-vasculitis-treatment-and-course-analysis-of-one-hundred-sixty-three-patients
#14
Carlo Salvarani, Robert D Brown, Teresa J H Christianson, John Huston, Caterina Giannini, Dylan V Miller, Gene G Hunder
OBJECTIVE: To describe the treatment and outcomes of patients with primary central nervous system (CNS) vasculitis. METHODS: We retrospectively studied a cohort of 163 consecutive patients with primary CNS vasculitis who were seen at the Mayo Clinic over a 29-year period. We analyzed treatments, treatment responses, and factors predictive of outcomes. RESULTS: A favorable response was observed in 85% of patients treated with prednisone alone and in 80% of patients treated with prednisone and cyclophosphamide...
June 2015: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/25523388/convexity-subarachnoid-hemorrhage-with-pib-positive-pet-scans-clinical-features-and-prognosis
#15
REVIEW
John V Ly, Shaloo Singhal, Christopher C Rowe, Peter Kempster, Simon Bower, Thanh G Phan
BACKGROUND: Cerebral amyloid angiopathy (CAA) has been reported to present as convexity subarachnoid hemorrhage (cSAH). Lesser known is that cSAH can herald intracerebral hemorrhage (ICH) and ischemic lesions. We present seven new cases with (11) C-Pittsburgh compound B (PiB) positive positron emission tomography (PET) scans including two with biopsy, review the literature and comment on clinical and radiological findings. METHODS: Patients with cSAH identified on CT, underwent MR imaging and MR angiography to exclude intracranial aneurysm...
May 2015: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
https://www.readbyqxmd.com/read/25174565/prevalence-and-clinicoradiological-analyses-of-patients-with-alzheimer-disease-coexisting-multiple-microbleeds
#16
Junpei Nagasawa, Tetsuhito Kiyozaka, Ken Ikeda
BACKGROUND: Pathologic findings of cerebral amyloid angiopathy (CAA) and Alzheimer disease (AD) coexist frequently. Both diseases are associated with β-amyloid deposition and dementia. We aimed to evaluate frequency and clinicoradiological profile of AD patients with multiple microbleeds (MBs). METHODS: We reviewed clinical records and magnetic resonance imaging (MRI) findings in patients with probable AD diagnosed by the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV), and National Institute of Neurological and Communicative Disorders and Stroke and Alzheimer's Disease and Related Disorders Association (NINCDS-ADRDA) criteria from 2009 to 2012...
October 2014: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/24876264/risk-factors-for-computed-tomography-angiography-spot-sign-in-deep-and-lobar-intracerebral-hemorrhage-are-shared
#17
MULTICENTER STUDY
Farid Radmanesh, Guido J Falcone, Christopher D Anderson, Thomas W K Battey, Alison M Ayres, Anastasia Vashkevich, Kristen A McNamara, Kristin Schwab, Javier M Romero, Anand Viswanathan, Steven M Greenberg, Joshua N Goldstein, Jonathan Rosand, H Bart Brouwers
BACKGROUND AND PURPOSE: Patients with intracerebral hemorrhage (ICH) who present with a spot sign on computed tomography angiography are at increased risk of hematoma expansion and poor outcome. Because primary ICH is the acute manifestation of chronic cerebral small vessel disease, we investigated whether different clinical or imaging characteristics predict spot sign presence, using ICH location as a surrogate for arteriolosclerosis- and cerebral amyloid angiopathy-related ICH. METHODS: Patients with primary ICH and available computed tomography angiography at presentation were included...
June 2014: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/24376545/hemodynamic-and-neuropathological-analysis-in-rats-with-aluminum-trichloride-induced-alzheimer-s-disease
#18
Szu-Ming Chen, Chi-Chen Fan, Ming-Shiuan Chiue, Chi Chou, Jyh-Horng Chen, Ruey-Shyang Hseu
BACKGROUND AND AIMS: Hemodynamic normality is crucial to maintaining the integrity of cerebral vessels and, therefore, preserving the cognitive functions of Alzheimer's disease patients. This study investigates the implications of the hemodynamic changes and the neuropathological diversifications of AlCl3-induced AD. METHODS: The experimental animals were 8- to 12-wk-old male Wistar rats. The rats were randomly divided into 2 groups: a control group and a (+)control group...
2013: PloS One
https://www.readbyqxmd.com/read/24119619/nontraumatic-convexity-subarachnoid-hemorrhage-different-etiologies-and-outcomes
#19
Ruth Geraldes, Paulo R Sousa, Ana C Fonseca, Filipa Falcão, Patrícia Canhão, Teresa Pinho e Melo
BACKGROUND: Nontraumatic convexity subarachnoid hemorrhage (cSAH) is a rarely reported condition with multiple etiologies. We report the clinical presentation, imaging findings, etiologies, and long-term outcomes of a case series of cSAH. METHODS: We retrospectively analyzed consecutive cases of cSAH, admitted at a Stroke Unit of a tertiary hospital (January 2006 to March 2012). Recorded variables were demographics, clinical presentation, complementary investigation, etiology, and outcome...
January 2014: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/23830597/coincidence-of-ischemic-stroke-and-recurrent-brain-haemorrhage-in-a-patient-with-klippel-trenaunay-syndrome
#20
Lena A Beume, Silke C Fuhrmann, Matthias Reinhard, Andreas Harloff
Cerebrovascular manifestations in Klippel-Trenaunay Syndrome (KTS) have been reported but are extremely rare. Case reports describe brain embolism in KTS-associated coagulopathy as well as bleeding due to arteriovenous malformations. We describe a 45-year-old patient with KTS and both acute ischemic stroke and repeated cerebral haemorrhage. The underlying aetiology of both events remained undetermined despite extensive diagnostic work-up, including coagulation tests and dynamic MR angiography. It is most likely that both a pathological coagulation and increased vessel fragility comparable to amyloid angiopathy were responsible for the combined brain lesions in this patient...
October 2013: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
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