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Sivashankar Chandrasekaran, Nader Darwish, Edwin O Chaharbakhshi, Carlos Suarez-Ahedo, Parth Lodhia, Benjamin G Domb
BACKGROUND: Advancements in instrumentation and techniques have extended the scope of hip arthroscopic surgery to treat complex osseous deformities that were previously best addressed with an open approach. Global pincer-type femoroacetabular impingement is an example of an abnormality requiring osseous correction with a technically challenging access point. PURPOSE: To report on the patterns of clinical presentation and intra-articular derangements, radiological associations, and minimum 2-year outcomes after hip arthroscopic surgery in patients with a lateral center edge angle (LCEA) >40° and profunda acetabulae in comparison with matched controls with normal acetabular coverage...
September 2017: American Journal of Sports Medicine
Benjamin Abo, William Selde
No abstract text is available yet for this article.
June 2016: JEMS: a Journal of Emergency Medical Services
William Selde, Will Smith
No abstract text is available yet for this article.
June 2016: JEMS: a Journal of Emergency Medical Services
M Gabriela Russo, Fanny Mendisco, Sergio A Avena, Cristina B Dejean, Verónica Seldes
Almost all pre-Hispanic societies from Quebrada de Humahuaca (north-western Argentina) buried their defuncts in domestic areas, demonstrating the importance of death and its daily presence among the living. Presumably, the collective graves contained related individuals, a hypothesis that can be tested through the study of ancient DNA. This study analyzes autosomal and uniparental genetic markers in individuals from two archaeological sites in Quebrada de Humahuaca occupied during the Late Formative (1450-1050 BP) and Regional Developments I (1050-700 BP) periods...
July 2016: Annals of Human Genetics
Sung Ho Lee, Sang-Ho Lee, Kang Taek Lim
OBJECTIVE: The purpose of this study was to investigate the effect of trans-sacral epiduroscopic laser decompression (SELD) in patients with a herniated lumbar disc. METHODS: This prospective case series study was designed to determine the outcomes of SELD with regard to reducing pain and improving the functional status in patients with low back pain (LBP) and radiculopathy caused by definitive neural compression confirmed by MRI. A total of 250 patients with LBP and simultaneous radiculopathy underwent SELD by applying a Ho:YAG laser...
March 2016: Photomedicine and Laser Surgery
Hee-Jeong Yang, Lydia M Bogomolnaya, Johanna R Elfenbein, Tiana Endicott-Yazdani, M Megan Reynolds, Steffen Porwollik, Pui Cheng, Xiao-Qin Xia, Michael McClelland, Helene Andrews-Polymenis
Contaminated chicken/egg products are major sources of human salmonellosis, yet the strategies used by Salmonella to colonize chickens are poorly understood. We applied a novel two-step hierarchical procedure to identify new genes important for colonization and persistence of Salmonella enterica serotype Typhimurium in chickens. A library of 182 S. Typhimurium mutants each containing a targeted deletion of a group of contiguous genes (for a total of 2,069 genes deleted) was used to identify regions under selection at 1, 3, and 9 days postinfection in chicks...
April 2016: Infection and Immunity
Matt D Wolfe
Selenophosphate synthetase, the selD gene product from Escherichia coli, is one of the enzymes required for the synthesis and specific insertion of selenocysteine into proteins directed by the TGA codon. Selenophosphate synthetases have been isolated from or are thought to be present in most organisms; however, the best characterized selenophosphate synthetase is from E. coli, in which both in vivo and in vitro studies have been performed. Leinfelder and coworkers showed that an E. coli mutant lacking an intact selD gene fails to incorporate Se into both the selenocysteine-containing enzyme formate dehydrogenase (FDH) and tRNA species that normally contain 2-selenouridine residues at the wobble position...
December 2004: EcoSal Plus
Ivan R Silva, Vitor H B Serrão, Livia R Manzine, Lívia M Faim, Marco T A da Silva, Raphaela Makki, Daniel M Saidemberg, Marinônio L Cornélio, Mário S Palma, Otavio H Thiemann
The synthesis of selenocysteine-containing proteins (selenoproteins) involves the interaction of selenocysteine synthase (SelA), tRNA (tRNA(Sec)), selenophosphate synthetase (SelD, SPS), a specific elongation factor (SelB), and a specific mRNA sequence known as selenocysteine insertion sequence (SECIS). Because selenium compounds are highly toxic in the cellular environment, the association of selenium with proteins throughout its metabolism is essential for cell survival. In this study, we demonstrate the interaction of SPS with the SelA-tRNA(Sec) complex, resulting in a 1...
December 4, 2015: Journal of Biological Chemistry
Joshua Mastenbrook, Paul Savino, Paul Mazurek, Jan Eichel, William Selde, Glenn Ekblad
OBJECTIVE: The aim of this study was to determine if a common air medical curriculum exists among Accreditation Council for Graduate Medical Education (ACGME) emergency medicine (EM) residencies. METHODS: Institutional review board exemption was obtained. A cross-sectional survey study design was used. All ACGME-approved EM residencies as of February 2013 were identified, and the program directors were e-mailed a 3-question survey. Descriptive statistics were calculated for each response, and a response bias analysis was completed...
September 2015: Air Medical Journal
Marco Mariotti, Didac Santesmasses, Salvador Capella-Gutierrez, Andrea Mateo, Carme Arnan, Rory Johnson, Salvatore D'Aniello, Sun Hee Yim, Vadim N Gladyshev, Florenci Serras, Montserrat Corominas, Toni Gabaldón, Roderic Guigó
Selenoproteins are proteins that incorporate selenocysteine (Sec), a nonstandard amino acid encoded by UGA, normally a stop codon. Sec synthesis requires the enzyme Selenophosphate synthetase (SPS or SelD), conserved in all prokaryotic and eukaryotic genomes encoding selenoproteins. Here, we study the evolutionary history of SPS genes, providing a map of selenoprotein function spanning the whole tree of life. SPS is itself a selenoprotein in many species, although functionally equivalent homologs that replace the Sec site with cysteine (Cys) are common...
September 2015: Genome Research
Anne M Schoening, M Susan Selde, Joely T Goodman, Joyce C Tow, Cindy L Selig, Chris Wichman, Amy Cosimano, Kimberly A Galt
This study evaluated learning outcomes and student perceptions of collaborative learning in an undergraduate nursing program. Participants in this 3-phase action research study included students enrolled in a traditional and an accelerated nursing program. The number of students who passed the unit examination was not significantly different between the 3 phases. Students had positive and negative perceptions about the use of collaborative learning.
July 2015: Nurse Educator
William Selde, Kyle English, Matthew Heffelfinger, Jan Eichel, Glenn Ekblad
INTRODUCTION: There is a large body of literature that shows that the AirTraq device achieves equal or superior rates of successful intubation in all classes of user. A recent prospective human trial of the device questioned the first pass success rate and whether effective training could occur outside the Operating Room (OR). The purpose of this study was to investigate the first pass success rate for intubation with the AirTraq (AT) device utilizing only mannequin training in an air ambulance setting from Aug...
November 2014: Air Medical Journal
Gao-Peng Li, Liang Jiang, Jia-Zuan Ni, Qiong Liu, Yan Zhang
BACKGROUND: Selenium (Se) and sulfur (S) are closely related elements that exhibit similar chemical properties. Some genes related to S metabolism are also involved in Se utilization in many organisms. However, the evolutionary relationship between the two utilization traits is unclear. RESULTS: In this study, we conducted a comparative analysis of the selenophosphate synthetase (SelD) family, a key protein for all known Se utilization traits, in all sequenced archaea...
2014: BMC Genomics
William Selde
No abstract text is available yet for this article.
September 2014: JEMS: a Journal of Emergency Medical Services
Marion Fuessl, Jörg Reinders, Peter J Oefner, Jürgen Heinze, Alexandra Schrempf
Selenoproteins (containing the 21st proteinogenic amino acid selenocysteine) play important roles throughout all domains of life. Surprisingly, a number of taxa have small selenoproteomes, and Hymenopteran insects appear to have fully lost selenoproteins. Nevertheless, their genomes contain genes for several proteins of the selenocysteine insertion machinery, including selenophosphate synthetase 1 (SELD/SPS1). At present, it is unknown whether this enzyme has a selenoprotein-independent function, and whether the gene is actually translated into a protein in Hymenoptera...
December 2014: Journal of Insect Physiology
Fanny Mendisco, Christine Keyser, Veronica Seldes, Clara Rivolta, Pablo Mercolli, Pablo Cruz, Axel E Nielsen, Eric Crubezy, Bertrand Ludes
This palaeogenetic study focused on the analysis of a late prehispanic Argentinean group from the Humahuaca valley, with the main aim of reconstructing its (micro)evolutionary history. The Humahuaca valley, a natural passageway from the eastern plains to the highlands, was the living environment of Andean societies whose cultural but especially biological diversity is still poorly understood. We analyzed the DNA extracted from 39 individuals who populated this upper valley during the Regional Development period (RDP) (between the 11th and 15th centuries CE), to determine their maternal and paternal genetic ancestry...
September 2014: Annals of Human Genetics
Scott Oglesbee, William Selde
No abstract text is available yet for this article.
April 2014: JEMS: a Journal of Emergency Medical Services
Y V Preobrazhenskaya, A I Stenko, M V Shvarts, V Y Lugovtsev
The transformation of the strain DH5α (TM)-T1(R) with plasmid vector pET11a containing the cloned gene of bacterial selenophosphate synthetase (SPS), selD, from the E. coli BL21-Gold (DE3) strain gives an overproducing strain of SPS with one synonymic substitution, E197D. The transformation efficiency was estimated as 8 × 10(8) CFU/ μ g plasmid DNA. 28 mg of highly purified preparation of recombinant SPS capable of binding TNP-ATP was eluted from DEAE-Sephadex column in amount of 15 % from the total soluble protein in crude extract...
2013: Journal of Amino Acids
M T A da Silva, I Silva-Jardim, O H Thiemann
Selenium (Se) is an essential trace element for several organisms and is present in proteins as selenocysteine (Sec or U), an amino acid that is chemically distinct from serine and cysteine by a single atom (Se instead of O or S, respectively). Sec is incorporated into selenoproteins at an in-frame UGA codon specified by an mRNA stem-loop structure called the selenocysteine incorporating sequence (SECIS) presented in selenoprotein mRNA and specific selenocysteine synthesis and incorporation machinery. Selenoproteins are presented in all domains but are not found in all organisms...
2014: Current Medicinal Chemistry
Ramsey C Tate, William Selde
No abstract text is available yet for this article.
July 2013: JEMS: a Journal of Emergency Medical Services
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