Yurong Zhang, Mengdi Zhang, Jie Yu, Wei Zhu, Qiaoyun Wang, Xiaohong Pan, Xue Gao, Jing Yang, Hongliu Sun
Previous studies have reported the possible neuroprotective effects of xenon treatment. The purpose of this study was to define the range of effective xenon ratio, most effective xenon ratio, and time-window for intervention in the kainic acid (KA) - induced status epilepticus (SE) rat model. Different ratios of xenon (35% xenon, 21% oxygen, 44% nitrogen, 50% xenon, 21% oxygen, 29% nitrogen, 70% xenon, 21% oxygen, and 9% nitrogen) were used to treat the KA-induced SE. Our results confirmed the anti-seizure role of 50 and 70% xenon mixture, with a stronger effect from the latter...
2019: Frontiers in Cellular Neuroscience