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Xenon anesthetic gas

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https://www.readbyqxmd.com/read/27492388/feasibility-tolerability-and-safety-of-pediatric-hyperpolarized-129-xe-magnetic-resonance-imaging-in-healthy-volunteers-and-children-with-cystic-fibrosis
#1
Laura L Walkup, Robert P Thomen, Teckla G Akinyi, Erin Watters, Kai Ruppert, John P Clancy, Jason C Woods, Zackary I Cleveland
BACKGROUND: Hyperpolarized (129)Xe is a promising contrast agent for MRI of pediatric lung function, but its safety and tolerability in children have not been rigorously assessed. OBJECTIVE: To assess the feasibility, safety and tolerability of hyperpolarized (129)Xe gas as an inhaled contrast agent for pediatric pulmonary MRI in healthy control subjects and in children with cystic fibrosis. MATERIALS AND METHODS: Seventeen healthy control subjects (ages 6-15 years, 11 boys) and 11 children with cystic fibrosis (ages 8-16 years, 4 boys) underwent (129)Xe MRI, receiving up to three doses of (129)Xe gas prepared by either a commercially available or a homebuilt (129)Xe polarizer...
November 2016: Pediatric Radiology
https://www.readbyqxmd.com/read/27253085/xenon-combined-with-therapeutic-hypothermia-is-not-neuroprotective-after-severe-hypoxia-ischemia-in-neonatal-rats
#2
Hemmen Sabir, Damjan Osredkar, Elke Maes, Thomas Wood, Marianne Thoresen
BACKGROUND: Therapeutic hypothermia (TH) is standard treatment following perinatal asphyxia in newborn infants. Experimentally, TH is neuroprotective after moderate hypoxia-ischemia (HI) in seven-day-old (P7) rats. However, TH is not neuroprotective after severe HI. After a moderate HI insult in newborn brain injury models, the anesthetic gas xenon (Xe) doubles TH neuroprotection. The aim of this study was to examine whether combining Xe and TH is neuroprotective as applied in a P7 rat model of severe HI...
2016: PloS One
https://www.readbyqxmd.com/read/27249317/breakthrough-in-xenon-capture-and-purification-using-adsorbent-supported-silver-nanoparticles
#3
Ludovic Deliere, Benoit Coasne, Sylvain Topin, Claire Gréau, Christophe Moulin, David Farrusseng
Rare gas capture and purification is a major challenge for energy, environment, and health applications. Of utmost importance for the nuclear industry, novel separation processes for Xe are urgently needed for spent nuclear fuel reprocessing and nuclear activity monitoring. The recovered, non-radioactive Xe is also of high economic value for lighting, surgical anesthetic, etc. Here, using adsorption and breakthrough experiments and statistical mechanics molecular simulation, we show the outstanding performance of zeolite-supported silver nanoparticles to capture/separate Xe at low concentrations (0...
July 4, 2016: Chemistry: a European Journal
https://www.readbyqxmd.com/read/26939898/sub-anesthetic-xenon-increases-erythropoietin-levels-in-humans-a-randomized-controlled-trial
#4
Christian Stoppe, Julia Ney, Martin Brenke, Andreas Goetzenich, Christoph Emontzpohl, Gereon Schälte, Oliver Grottke, Manfred Moeller, Rolf Rossaint, Mark Coburn
BACKGROUND: The licensed anesthetic xenon, which exerts organ protective properties, was recently added by the World Anti-Doping Agency to the list of prohibited substances. Xenon is supposed to trigger the production of hypoxia-inducible factor 1α (HIF-1α) and subsequently erythropoietin, but data are limited to in vivo experimental work. Therefore we evaluated the effect of xenon on erythropoietin levels in healthy persons. METHODS: Twenty-four healthy volunteers were randomly assigned either to a group spontaneously breathing xenon 30 % (Xe/O2 30 %/60 %) or a group breathing control gas (N2/O2 40 %/60 %) for 45 min...
March 3, 2016: Sports Medicine
https://www.readbyqxmd.com/read/26922993/-xenon-from-rare-gaz-to-doping-product
#5
Camille Tassel, Brendan Le Daré, Isabelle Morel, Thomas Gicquel
Doping is defined as the use of processes or substances to artificially increase physical or mental performance. Xenon is a noble gas used as an anesthetic and recently as a doping agent. Xenon is neuroprotective as an antagonist of NMDA glutamate receptors. Xenon stimulates the synthesis of erythropoietin (EPO) by increase of hypoxia inducible factor (HIF). Xenon would be a new doping product, maintaining doping methods ahead of detection.
April 2016: La Presse Médicale
https://www.readbyqxmd.com/read/26658205/using-screen-based-simulation-of-inhaled-anaesthetic-delivery-to-improve-patient-care
#6
REVIEW
J H Philip
Screen-based simulation can improve patient care by giving novices and experienced clinicians insight into drug behaviour. Gas Man(®) is a screen-based simulation program that depicts pictorially and graphically the anaesthetic gas and vapour tension from the vaporizer to the site of action, namely the brain and spinal cord. The gases and vapours depicted are desflurane, enflurane, ether, halothane, isoflurane, nitrogen, nitrous oxide, sevoflurane, and xenon. Multiple agents can be administered simultaneously or individually and the results shown on an overlay graph...
December 2015: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/25900233/stellate-ganglion-block-compared-with-xenon-light-irradiation-is-a-more-effective-treatment-of-neurosensory-deficits-resulting-from-orthognathic-surgery-as-measured-by-current-perception-threshold
#7
COMPARATIVE STUDY
Kentaro Nogami, Shogo Taniguchi
PURPOSE: The aim of this study was to evaluate the relative effectiveness of stellate ganglion blockade (SGB) versus xenon light irradiation (XLI) for the treatment of neurosensory deficits resulting from orthognathic surgery as determined by a comparison of prospective measurements of electrical current perception thresholds (CPTs) and ranged CPTs (R-CPTs). MATERIALS AND METHODS: CPT and R-CPT in the mental foramen area were measured during electrical stimulation at 98 different sites on the body in patients who had undergone orthognathic surgery...
July 2015: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/25885293/anesthetic-gases-and-global-warming-potentials-prevention-and-future-of-anesthesia
#8
REVIEW
Hina Gadani, Arun Vyas
Global warming refers to an average increase in the earth's temperature, which in turn causes changes in climate. A warmer earth may lead to changes in rainfall patterns, a rise in sea level, and a wide range of impacts on plants, wildlife, and humans. Greenhouse gases make the earth warmer by trapping energy inside the atmosphere. Greenhouse gases are any gas that absorbs infrared radiation in the atmosphere and include: water vapor, carbon dioxide (CO2), methane (CH4), nitrous oxide (N2O), halogenated fluorocarbons (HCFCs), ozone (O3), perfluorinated carbons (PFCs), and hydrofluorocarbons (HFCs)...
January 2011: Anesthesia, Essays and Researches
https://www.readbyqxmd.com/read/25612767/modelling-of-noble-anaesthetic-gases-and-high-hydrostatic-pressure-effects-in-lipid-bilayers
#9
Yevgeny Moskovitz, Hui Yang
Our objective was to study molecular processes that might be responsible for inert gas narcosis and high-pressure nervous syndrome. The classical molecular dynamics trajectories (200 ns) of dioleoylphosphatidylcholine (DOPC) bilayers simulated by the Berger force field were evaluated for water and the atomic distribution of noble gases around DOPC molecules in the pressure range of 1-1000 bar and at a temperature of 310 K. Xenon and argon have been tested as model gases for general anaesthetics, and neon has been investigated for distortions that are potentially responsible for neurological tremors in hyperbaric conditions...
March 21, 2015: Soft Matter
https://www.readbyqxmd.com/read/25601327/targets-involved-in-cardioprotection-by-the-non-anesthetic-noble-gas-helium
#10
REVIEW
Nina C Weber, Kirsten F Smit, Markus W Hollmann, Benedikt Preckel
Research data from the past decade indicate that noble gases like xenon and helium exert profound cardioprotection when applied before, during or after organ ischemia. Of all noble gases, especially helium, has gained interest in the past years because it does not have an anesthetic "side effect" like xenon, allowing application of this specific gas in numerous clinical ischemia/reperfusion situations. Because helium has several unique characteristics and no hemodynamic side effects, helium could be administered in severely ill patients...
2015: Current Drug Targets
https://www.readbyqxmd.com/read/25343799/radiation-dose-and-image-quality-in-k-edge-subtraction-computed-tomography-of-lung-in-vivo
#11
COMPARATIVE STUDY
S Strengell, J Keyriläinen, P Suortti, S Bayat, A R A Sovijärvi, L Porra
K-edge subtraction computed tomography (KES-CT) allows simultaneous imaging of both structural features and regional distribution of contrast elements inside an organ. Using this technique, regional lung ventilation and blood volume distributions can be measured experimentally in vivo. In order for this imaging technology to be applicable in humans, it is crucial to minimize exposure to ionizing radiation with little compromise in image quality. The goal of this study was to assess the changes in signal-to-noise ratio (SNR) of KES-CT lung images as a function of radiation dose...
November 2014: Journal of Synchrotron Radiation
https://www.readbyqxmd.com/read/25333593/a-technique-for-administering-xenon-gas-anesthesia-during-surgical-procedures-in-mice
#12
Arne Mathias Ruder, Michaela Schmidt, Alessia Ludiro, Marco A Riva, Peter Gass
Carrying out invasive procedures in animals requires the administration of anesthesia. Xenon gas offers advantages as an anesthetic agent compared with other agents, such as its protection of the brain and heart from hypoxia-induced damage. The high cost of xenon gas has limited its use as an anesthetic in animal experiments, however. The authors designed and constructed simple boxes for the induction and maintenance of xenon gas and isoflurane anesthesia in small rodents in order to minimize the amount of xenon gas that is wasted...
November 2014: Lab Animal
https://www.readbyqxmd.com/read/25211169/crystallographic-studies-with-xenon-and-nitrous-oxide-provide-evidence-for-protein-dependent-processes-in-the-mechanisms-of-general-anesthesia
#13
Jacques H Abraini, Guillaume Marassio, Helene N David, Beatrice Vallone, Thierry Prangé, Nathalie Colloc'h
BACKGROUND: The mechanisms by which general anesthetics, including xenon and nitrous oxide, act are only beginning to be discovered. However, structural approaches revealed weak but specific protein-gas interactions. METHODS: To improve knowledge, we performed x-ray crystallography studies under xenon and nitrous oxide pressure in a series of 10 binding sites within four proteins. RESULTS: Whatever the pressure, we show (1) hydrophobicity of the gas binding sites has a screening effect on xenon and nitrous oxide binding, with a threshold value of 83% beyond which and below which xenon and nitrous oxide, respectively, binds to their sites preferentially compared to each other; (2) xenon and nitrous oxide occupancies are significantly correlated respectively to the product and the ratio of hydrophobicity by volume, indicating that hydrophobicity and volume are binding parameters that complement and oppose each other's effects; and (3) the ratio of occupancy of xenon to nitrous oxide is significantly correlated to hydrophobicity of their binding sites...
November 2014: Anesthesiology
https://www.readbyqxmd.com/read/25001620/xenon-decreases-cell-migration-and-secretion-of-a-pro-angiogenesis-factor-in-breast-adenocarcinoma-cells-comparison-with-sevoflurane
#14
COMPARATIVE STUDY
S A Ash, G I Valchev, M Looney, A Ni Mhathuna, P D Crowley, H C Gallagher, D J Buggy
BACKGROUND: While volatile agents have been implicated in metastasis-enhancing effects on cancer cells, the effects of xenon are unknown. We investigated xenon- and sevoflurane-mediated effects on migration and expression of angiogenesis biomarkers in human breast adenocarcinoma cells. METHODS: MDA-MB-231 and MCF-7 cells were exposed to xenon 70% with O2 25%, CO2 5%; control gas containing O2 25%, CO2 5%, N2 70%; or sevoflurane 2.5 vol% administered in O2 60%, N2 37%, or control gas...
July 2014: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/24861600/measuring-xenon-in-human-plasma-and-blood-by-gas-chromatography-mass-spectrometry
#15
Mario Thevis, Thomas Piper, Hans Geyer, Andreas Thomas, Maximilian S Schaefer, Peter Kienbaum, Wilhelm Schänzer
RATIONALE: Due to the favorable pharmacokinetic properties and minimal side effects of xenon, its use in modern anesthesia has been well accepted, and recent studies further demonstrated the intra- and postoperative neuro-, cardio-, and reno-protective action of the noble gas. Since the production of the hypoxia-inducible factor 1α (HIF-1α) and its downstream effector erythropoietin as well as noradrenalin reuptake inhibition have been found to play key roles in this context, the question arose as to whether the use of xenon is a matter for doping controls and preventive doping research...
July 15, 2014: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/24813496/-how-xenon-works-neuro-and-cardioprotection-mechanisms
#16
REVIEW
Ricardo Morais, Luísa Andrade, André Lourenço, Jorge Tavares
INTRODUCTION: The Xenon, a noble gas, has anesthetics properties, associated with remarkable hemodynamic stability as well as cardioprotective, neuroprotective proprieties. Its physicochemical characteristics give him a quick induction and emergence of anesthesia, being free of deleterious effects in all organs and showing no teratogenicity. Such properties have led to a growing interest in improving the knowledge about this noble gas, in order to assess the mechanisms of neuro and cardioprotection induced and to assess the clinical indications for its use...
March 2014: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/24440817/neuroprotective-gases-fantasy-or-reality-for-clinical-use
#17
REVIEW
Jiao Deng, Chong Lei, Yu Chen, Zongping Fang, Qianzi Yang, Haopeng Zhang, Min Cai, Likai Shi, Hailong Dong, Lize Xiong
The neuroprotective properties for certain medical gases have been observed for decades, leading to extensive research that has been widely reported and continues to garner interest. Common gases including oxygen, hydrogen, carbon dioxide and nitric oxide, volatile anesthetics such as isoflurane, sevoflurane, halothane, enflurane and desflurane, non-volatile anesthetics such as xenon and nitrous oxide, inert gases such as helium and argon, and even gases classically considered to be toxic (e.g., hydrogen sulfide and carbon monoxide) have all been supported by the evidence alluding to their use as potential neuroprotective agents...
April 2014: Progress in Neurobiology
https://www.readbyqxmd.com/read/24299622/xenon-and-other-volatile-anesthetics-change-domain-structure-in-model-lipid-raft-membranes
#18
Michael Weinrich, David L Worcester
Inhalation anesthetics have been in clinical use for over 160 years, but the molecular mechanisms of action continue to be investigated. Direct interactions with ion channels received much attention after it was found that anesthetics do not change the structure of homogeneous model membranes. However, it was recently found that halothane, a prototypical anesthetic, changes domain structure of a binary lipid membrane. The noble gas xenon is an excellent anesthetic and provides a pivotal test of the generality of this finding, extended to ternary lipid raft mixtures...
December 19, 2013: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/24118055/the-effects-of-xenon-and-nitrous-oxide-gases-on-alcohol-relapse
#19
Valentina Vengeliene, Baptiste Bessiere, Jan Pype, Rainer Spanagel
BACKGROUND: In recent years, the glutamate theory of alcoholism has emerged as a major theory in the addiction research field and N-methyl-d-aspartate (NMDA) receptors have been shown to play a major role in alcohol craving and relapse. The NMDA receptors are considered as the primary side of action of the anesthetic gases xenon (Xe) and nitrous oxide (N2 O). Despite the rapid on/off kinetics of these gases on the NMDA receptor, a brief gas exposure can induce an analgesic or antireward effect lasting several days...
February 2014: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/24025645/early-treatment-with-xenon-protects-against-the-cold-ischemia-associated-with-chronic-allograft-nephropathy-in-rats
#20
Hailin Zhao, Xianghong Luo, Zhaowei Zhou, Juying Liu, Catherine Tralau-Stewart, Andrew J T George, Daqing Ma
Chronic allograft nephropathy (CAN) is a common finding in kidney grafts with functional impairment. Prolonged hypothermic storage-induced ischemia-reperfusion injury is associated with the early onset of CAN. As the noble gas xenon is clinically used as an anesthetic and has renoprotective properties in a rodent model of ischemia-reperfusion injury, we studied whether early treatment with xenon could attenuate CAN associated with prolonged hypothermic storage. Exposure to xenon enhanced the expression of insulin growth factor-1 (IGF-1) and its receptor in human proximal tubular (HK-2) cells, which, in turn, increased cell proliferation...
January 2014: Kidney International
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