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https://www.readbyqxmd.com/read/29773717/stk11-lkb1-mutations-and-pd-1-inhibitor-resistance-in-kras-mutant-lung-adenocarcinoma
#1
Ferdinandos Skoulidis, Michael E Goldberg, Danielle M Greenawalt, Matthew D Hellmann, Mark M Awad, Justin F Gainor, Alexa B Schrock, Ryan J Hartmaier, Sally E Trabucco, Laurie Gay, Siraj M Ali, Julia A Elvin, Gaurav Singal, Jeffrey S Ross, David Fabrizio, Peter M Szabo, Han Chang, Ariella Sasson, Sujaya Srinivasan, Stefan Kirov, Joseph Szustakowski, Patrik Vitazka, Robin Edwards, Jose A Bufill, Neelesh Sharma, Sai-Hong I Ou, Nir Peled, David R Spigel, Hira Rizvi, Elizabeth Jimenez Aguilar, Brett W Carter, Jeremy Erasmus, Darragh F Halpenny, Andrew J Plodkowski, Niamh M Long, Mizuki Nishino, Warren L Denning, Ana Galan-Cobo, Haifa Hamdi, Taghreed Hirz, Pan Tong, Jing Wang, Jaime Rodriguez-Canales, Pamela A Villalobos, Edwin R Parra, Neda Kalhor, Lynette M Sholl, Jennifer L Sauter, Achim A Jungbluth, Mari Mino-Kenudson, Roxana Azimi, Yasir Y Elamin, Jianjun Zhang, Giulia C Leonardi, Fei Jiang, Kwok-Kin Wong, J Jack Lee, Vassiliki A Papadimitrakopoulou, Ignacio I Wistuba, Vincent A Miller, Garrett M Frampton, Jedd D Wolchok, Alice T Shaw, Pasi A Jänne, Philip J Stephens, Charles M Rudin, William J Geese, Lee A Albacker, John V Heymach
KRAS is the most common oncogenic driver in lung adenocarcinoma (LUAC). We previously reported that STK11/LKB1 (KL) or TP53 (KP) co-mutations define distinct subgroups of KRAS-mutant LUAC. Here, we examine the efficacy of PD-1 inhibitors in these subgroups. Objective response rates to PD-1 blockade differed significantly among KL (7.4%), KP (35.7%), and K-only (28.6%) subgroups (P<0.001) in the SU2C cohort (174 patients) with KRAS-mutant LUAC and in patients treated with nivolumab in the CheckMate-057 phase 3 trial (0% vs 57...
May 17, 2018: Cancer Discovery
https://www.readbyqxmd.com/read/29769251/systematic-review-and-network-meta-analysis-of-resective-surgery-for-mesial-temporal-lobe-epilepsy
#2
Puneet Jain, George Tomlinson, Carter Snead, Beate Sander, Elysa Widjaja
OBJECTIVE: To evaluate the effectiveness of anterior temporal lobectomy (ATL) versus selective amygdalohippocampectomy (SAH) on seizure-free outcome in patients with temporal lobe epilepsy, using both direct and indirect evidence from the literature. METHODS: MEDLINE, Embase and Cochrane databases were searched for original research articles and systematic reviews comparing ATL versus SAH, and ATL or SAH versus medical management (MM). The outcome was seizure freedom at 12 months of follow-up or longer...
May 16, 2018: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/29767735/untargeted-metabolomics-identifies-novel-potential-biomarkers-of-habitual-food-intake-in-a-cross-sectional-study-of-postmenopausal-women
#3
Ying Wang, Susan M Gapstur, Brian D Carter, Terryl J Hartman, Victoria L Stevens, Mia M Gaudet, Marjorie L McCullough
Background: Recent studies suggest that untargeted metabolomics is a promising tool to identify novel biomarkers of individual foods. However, few large cross-sectional studies with comprehensive data on habitual diet and circulating metabolites have been conducted. Objective: We aimed to identify potential food biomarkers and evaluate their predictive accuracy. Methods: We conducted a cross-sectional analysis of consumption of 91 food groups or items, assessed by a 152-item food-frequency questionnaire, in relation to 1186 serum metabolites measured by mass spectrometry-based platforms from 1369 nonsmoking postmenopausal women (mean age = 68...
May 15, 2018: Journal of Nutrition
https://www.readbyqxmd.com/read/29767358/sureselect-xt-rna-direct-a-technique-for-expression-analysis-through-sequencing-of-target-enriched-ffpe-total-rna
#4
Jennifer Carter Jones, Alex P Siebold, Carolina Becker Livi, Anne Bergstrom Lucas
Gene expression profiling of samples from biobanks requires a method that can be used with intact as well as partially degraded RNA. High throughput applications can benefit from reducing the number of processing steps including eliminating the poly(A) selection and ribosomal depletion steps. When performing targeted capture, we have found that we can eliminate the upfront poly(A) selection/ribosomal depletion steps that cause bias in standard mRNA-Seq workflows. This target enrichment solution allows for whole transcriptome or customized content to characterize differential gene expression patterns (especially for mid/low level transcripts)...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29767350/inverse-relationship-between-changes-of-maximal-aerobic-capacity-and-changes-in-walking-economy-after-weight-loss
#5
Juliano H Borges, Stephen J Carter, Harshvardhan Singh, Gary R Hunter
PURPOSE: The aims of this study were to: (1) determine the relationships between maximum oxygen uptake ([Formula: see text]O2max ) and walking economy during non-graded and graded walking among overweight women and (2) examine potential differences in [Formula: see text]O2max and walking economy before and after weight loss. METHODS: One-hundred and twenty-four premenopausal women with a body mass index (BMI) between 27 and 30 kg/m2 were randomly assigned to one of three groups: (a) diet only; (b) diet and aerobic exercise training; and (c) diet and resistance exercise training...
May 16, 2018: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/29758104/restricted-speciation-and-supramolecular-assembly-in-the-5f-block
#6
Korey P Carter, Robert G Surbella Iii, Mark Kalaj, Christopher L Cahill
Hybrid materials bearing elements from the 5f block display a rich diversity of coordination geometries, connectivities, and assembly motifs. Exemplary in this regard have been the uranyl coordination polymers, which feature a wide range of secondary building units resulting from hydrolysis and oligomerization of the [UO2]2+ cation. An alternative approach to novel materials, however, suppresses hydrolysis and relies on non-covalent interactions (e.g. hydrogen or halogen bonding) to direct assembly of a more limited suite of species or building units...
May 14, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29754458/integrating-point-of-care-testing-into-a-community-emergency-department-a-mixed-methods-evaluation
#7
Jesse M Pines, Mark S Zocchi, Caitlin Carter, Charles Z Marriott, Matthew Bernard, Leah H Warner
STUDY OBJECTIVE: Point-of-care testing (POCT) is a commonly used technology that hastens the time to laboratory results in emergency departments (ED). We evaluated an ED-based POCT program on ED length of stay and time to care, coupled with qualitative interviews of local ED stakeholders. METHODS: We conducted a mixed-methods study (2012-16) to examine the impact of point-of-care testing in a single, community ED. The quantiative analysis involved an observational before-after study comparing time to laboratory test result (POC troponin or POC chemistry) and ED length of stay after implementation of POCT, using a propensity-weighted interrupted time series analysis (ITSA)...
May 13, 2018: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/29750367/efficacy-of-maternal-choline-supplementation-during-pregnancy-in-mitigating-adverse-effects-of-prenatal-alcohol-exposure-on-growth-and-cognitive-function-a-randomized-double-blind-placebo-controlled-clinical-trial
#8
Sandra W Jacobson, R Colin Carter, Christopher D Molteno, Mark E Stanton, Jane Herbert, Nadine M Lindinger, Catherine E Lewis, Neil C Dodge, H Eugene Hoyme, Steven H Zeisel, Ernesta M Meintjes, Christopher P Duggan, Joseph L Jacobson
BACKGROUND: We recently demonstrated the acceptability and feasibility of a randomized, double-blind choline supplementation intervention for heavy drinking women during pregnancy. In this paper, we report our results relating to the efficacy of this intervention in mitigating adverse effects of prenatal alcohol exposure on infant growth and cognitive function. METHODS: 69 Cape Coloured (mixed ancestry) heavy drinkers in Cape Town, South Africa, recruited in mid-pregnancy, were randomly assigned to receive a daily oral dose of either 2 g of choline or placebo from time of enrollment until delivery...
May 11, 2018: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/29750366/feasibility-and-acceptability-of-maternal-choline-supplementation-in-heavy-drinking-pregnant-women-a-randomized-double-blind-placebo-controlled-clinical-trial
#9
Sandra W Jacobson, R Colin Carter, Christopher D Molteno, Ernesta M Meintjes, Marjanne Senekal, Nadine M Lindinger, Neil C Dodge, Steven H Zeisel, Christopher P Duggan, Joseph L Jacobson
BACKGROUND: Choline, an essential nutrient, serves as a methyl-group donor for DNA methylation and is a constituent of the neurotransmitter acetylcholine and a precursor to major components of cell membranes. Findings from animal studies suggest that choline supplementation during pregnancy may mitigate adverse effects of prenatal alcohol exposure on growth and neurocognitive function. We conducted a randomized, double-blind exploratory trial to examine feasibility and acceptability of a choline supplementation intervention during pregnancy...
May 11, 2018: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/29749915/continuous-infusion-of-low-dose-unfractionated-heparin-after-aneurysmal-subarachnoid-hemorrhage-a-preliminary-study-of-cognitive-outcomes
#10
Robert F James, Nicolas K Khattar, Zaid S Aljuboori, Paul S Page, Elaine Y Shao, Lacey M Carter, Kimberly S Meyer, Michael W Daniels, John Craycroft, John R Gaughen, M Imran Chaudry, Shesh N Rai, D Erik Everhart, J Marc Simard
OBJECTIVE Cognitive dysfunction occurs in up to 70% of aneurysmal subarachnoid hemorrhage (aSAH) survivors. Low-dose intravenous heparin (LDIVH) infusion using the Maryland protocol was recently shown to reduce clinical vasospasm and vasospasm-related infarction. In this study, the Montreal Cognitive Assessment (MoCA) was used to evaluate cognitive changes in aSAH patients treated with the Maryland LDIVH protocol compared with controls. METHODS A retrospective analysis of all patients treated for aSAH between July 2009 and April 2014 was conducted...
May 11, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29742531/spontaneous-healing-of-a-bucket-handle-posterior-labral-detachment-after-hip-dislocation-in-a-five-year-old-child-a-case-report
#11
R Carter Clement, Daniel P Carpenter, Anna V Cuomo
CASE: We report the case of a 5-year-old girl who sustained a traumatic hip dislocation and a spontaneous reduction that was complicated by nonconcentric reduction and a large bucket-handle labral detachment. This injury was managed, via an anterior approach, with capsulotomy and reduction of the large interposed labral tear with an attached osteochondral fragment from the posterior aspect of the acetabulum. No additional surgical treatment was employed for the labral tear. CONCLUSION: The patient ultimately demonstrated radiographic healing and an asymptomatic, clinically stable hip...
May 9, 2018: JBJS Case Connector
https://www.readbyqxmd.com/read/29740130/publisher-correction-the-cytoplasmic-dynein-transport-machinery-and-its-many-cargoes
#12
Samara L Reck-Peterson, William B Redwine, Ronald D Vale, Andrew P Carter
In Figure 1c of the original article, ARP1 was incorrectly labelled as ARP11. The highlight for reference 37 was mistakenly placed under reference 36 and the highlight for reference 29 should have also referred to reference 16 (instead of 19). The HTML and PDF versions of the article have now been corrected.
May 8, 2018: Nature Reviews. Molecular Cell Biology
https://www.readbyqxmd.com/read/29739952/translational-study-identifies-xpf-and-mus81-as-predictive-biomarkers-for-oxaliplatin-based-peri-operative-chemotherapy-in-patients-with-esophageal-adenocarcinoma
#13
T P MacGregor, R Carter, R S Gillies, J M Findlay, C Kartsonaki, F Castro-Giner, N Sahgal, L M Wang, R Chetty, N D Maynard, J B Cazier, F Buffa, P J McHugh, I Tomlinson, M R Middleton, R A Sharma
Oxaliplatin-based chemotherapy is used to treat patients with esophageal adenocarcinoma (EAC), but no biomarkers are currently available for patient selection. We performed a prospective, clinical trial to identify potential biomarkers associated with clinical outcomes. Tumor tissue was obtained from 38 patients with resectable EAC before and after 2 cycles of oxaliplatin-fluorouracil chemotherapy. Pre-treatment mRNA expression of 280 DNA repair (DNAR) genes was tested for association with histopathological regression at surgery, disease-free survival (DFS) and overall survival (OS)...
May 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29738601/the-meniscal-comma-sign-characterization-and-treatment-of-a-displaced-fragment-in-the-meniscotibial-recess
#14
Hytham S Salem, Aaron H Carter, Weilong J Shi, Fotios P Tjoumakaris, Steven B Cohen, Adam C Zoga, Kevin B Freedman
Displaced parrot beak flap tears in the meniscotibial recess are complex tears of the meniscus that begin as central radial tears and progressively extend toward the periphery, creating a detached fragment. These tears have not been described in the literature, but the authors have described them as the "meniscal comma sign" based on their appearance on magnetic resonance imaging. Displaced fragments are clinically significant because of the pain and mechanical symptoms they can cause as a result of tenting of the deep medial collateral ligament...
May 8, 2018: Orthopedics
https://www.readbyqxmd.com/read/29737948/heat-stress-and-hepatic-laser-thermal-ablation-induce-hepatocellular-carcinoma-growth-role-of-pi3k-mtor-akt-signaling
#15
Danielle E Jondal, Scott M Thompson, Kim A Butters, Bruce E Knudsen, Jill L Anderson, Rickey E Carter, Lewis R Roberts, Matthew R Callstrom, David A Woodrum
Purpose To determine if heat stress and hepatic laser thermal ablation induce hepatocellular carcinoma (HCC) growth and to identify growth factors induced by heat stress. Materials and Methods Non-heat-stressed HCC cells were cocultured with HCC cells or hepatocytes that were heat stressed at 37°C (physiologic), 45°C (moderate), or 50°C (severe) for 10 minutes and proliferation monitored with bioluminescence imaging for up to 6 days after heat stress (three experiments). Rats bearing orthotopic N1S1 HCC were randomly assigned to undergo immediate sham or laser thermal (3 W for 60 or 90 seconds; hereafter, 3W×60s and 3W×90s, respectively) ablation of the median (local) or left (distant) hepatic lobe, and tumor growth was monitored with magnetic resonance imaging for up to 18 days after ablation (six or more rats per group)...
May 8, 2018: Radiology
https://www.readbyqxmd.com/read/29736017/an-absolute-sodium-abundance-for-a-cloud-free-hot-saturn-exoplanet
#16
N Nikolov, D K Sing, J J Fortney, J M Goyal, B Drummond, T M Evans, N P Gibson, E J W De Mooij, Z Rustamkulov, H R Wakeford, B Smalley, A J Burgasser, C Hellier, Ch Helling, N J Mayne, N Madhusudhan, T Kataria, J Baines, A L Carter, G E Ballester, J K Barstow, J McCleery, J J Spake
Broad absorption signatures from alkali metals, such as the sodium (Na I) and potassium (K I) resonance doublets, have long been predicted in the optical atmospheric spectra of cloud-free irradiated gas giant exoplanets1-3 . However, observations have revealed only the narrow cores of these features rather than the full pressure-broadened profiles4-6 . Cloud and haze opacity at the day-night planetary terminator are considered to be responsible for obscuring the absorption-line wings, which hinders constraints on absolute atmospheric abundances7-9 ...
May 7, 2018: Nature
https://www.readbyqxmd.com/read/29727514/potential-patient-harms-from-misinterpretation-of-publically-reported-surgical-outcomes
#17
Niranjan J Sathianathen, Jacob Albersheim-Carter, Lucas Labine, Brett Watson, Badrinath R Konety, Christopher J Weight
OBJECTIVE: To determine how the general public interprets surgical complication rates presented from a publicly available online surgical-rating website. MATERIALS AND METHODS: An in-person electronic survey was administered at the local State Fair to a convenience sample. Participants were presented with a representative output from an online surgeon rating website and were asked to choose from three statistically equivalent surgeons for a hypothetical medical decision...
May 4, 2018: BJU International
https://www.readbyqxmd.com/read/29720431/global-distribution-of-invasive-serotype-35d-streptococcus-pneumoniae-post-pcv13-introduction
#18
Stephanie W Lo, Rebecca A Gladstone, Andries J van Tonder, Paulina A Hawkins, Brenda Kwambana-Adams, Jennifer E Cornick, Shabir A Madhi, Susan A Nzenze, Mignon du Plessis, Rama Kandasamy, Philip E Carter, Özgen Köseoglu Eser, Pak Leung Ho, Naima Elmdaghri, Sadia Shakoor, Stuart C Clarke, Martin Antonio, Dean B Everett, Anne von Gottberg, Keith P Klugman, Lesley McGee, Robert F Breiman, Stephen D Bentley
A newly recognized pneumococcal serotype 35D, which differs from the 35B polysaccharide in structure and serology by not binding to factor serum 35a, was recently reported. The genetic basis for this distinctive serology is due to the presence of an inactivating mutation in wciG , which encodes an O-acetyltransferase responsible for O-acetylation of a galactofuranose. Here, we assessed the genomic data of a worldwide pneumococcal collection to identify serotype 35D isolates and understand their geographical distribution, genetic background and invasiveness potential...
May 2, 2018: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29720195/characterization-of-plasmodium-relictum-a-cosmopolitan-agent-of-avian-malaria
#19
Gediminas Valkiūnas, Mikas Ilgūnas, Dovilė Bukauskaitė, Karin Fragner, Herbert Weissenböck, Carter T Atkinson, Tatjana A Iezhova
BACKGROUND: Microscopic research has shown that Plasmodium relictum is the most common agent of avian malaria. Recent molecular studies confirmed this conclusion and identified several mtDNA lineages, suggesting the existence of significant intra-species genetic variation or cryptic speciation. Most identified lineages have a broad range of hosts and geographical distribution. Here, a rare new lineage of P. relictum was reported and information about biological characters of different lineages of this pathogen was reviewed, suggesting issues for future research...
May 2, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29718816/a-post-marketing-surveillance-study-of-chronic-wounds-treated-with-a-native-collagen-calcium-alginate-dressing
#20
Matthew Sabo, Lam Le, Raphael A Yaakov, Marissa Carter, Thomas E Serena
Chronic wounds (ie, wounds that fail to progress through a normal, orderly, timely sequence of repair) continue to pose significant clinical and economic burdens. A prospective, descriptive, 3-week post-marketing surveillance study was conducted across 3 wound care centers in the United States to evaluate the effectiveness of a collagen calcium alginate dressing on chronic wounds in conjunction with standard care (SC) practices (eg, offloading, debridement, compression) to support healing. Eligible participants had to be >18 years of age, have at least 1 chronic wound, and no known sensitivity to collagen...
April 2018: Ostomy/wound Management
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