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https://www.readbyqxmd.com/read/27922028/a-randomized-double-blind-placebo-controlled-trial-to-examine-the-effectiveness-of-lubiprostone-on-constipation-symptoms-and-colon-transit-time-in-diabetic-patients
#1
Jennifer Christie, Sagar Shroff, Nikrad Shahnavaz, Latoya A Carter, Melanie S Harrison, Karan A Dietz-Lindo, John Hanfelt, Shanthi Srinivasan
OBJECTIVES: Constipation is the most common GI symptom in patients with diabetes mellitus (DM). Importantly, patients with constipation have lower health-related quality of life than those without constipation. Effective therapies for constipation are limited and there is a paucity of data evaluating the treatment of constipation in diabetics. METHODS: Diabetic patients with chronic idiopathic constipation (CIC) as defined by Rome III criteria were recruited from outpatient clinics at a tertiary-care center and a Veterans Administration Hospital...
December 6, 2016: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/27913910/a-randomized-trial-of-displaying-paid-price-information-on-imaging-study-and-procedure-ordering-rates
#2
Alyna T Chien, Lisa Soleymani Lehmann, Laura A Hatfield, Kate E Koplan, Carter R Petty, Anna D Sinaiko, Meredith B Rosenthal, Thomas D Sequist
BACKGROUND: Prior studies have demonstrated how price transparency lowers the test-ordering rates of trainees in hospitals, and physician-targeted price transparency efforts have been viewed as a promising cost-controlling strategy. OBJECTIVE: To examine the effect of displaying paid-price information on test-ordering rates for common imaging studies and procedures within an accountable care organization (ACO). DESIGN: Block randomized controlled trial for 1 year...
December 2, 2016: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/27909231/influence-of-dietary-nitrate-supplementation-on-physiological-and-muscle-metabolic-adaptations-to-sprint-interval-training
#3
Christopher Thompson, Lee J Wylie, Jamie R Blackwell, Jonathan Fulford, Matthew I Black, James Kelly, Sinead T J McDonagh, James Carter, Stephen J Bailey, Anni Vanhatalo, Andrew M Jones
We hypothesized that 4 weeks of dietary nitrate supplementation would enhance exercise performance and muscle metabolic adaptations to sprint interval training (SIT). Thirty six recreationally-active subjects, matched on key variables at baseline, completed a series of exercise tests before and following a 4 week period in which they were allocated to one of the following groups: 1) SIT and NO3(-)-depleted beetroot juice as a placebo (SIT+PL); 2) SIT and NO3(-)-rich beetroot juice (~13mmol NO3(-)/day; SIT+BR); or 3) no training and NO3(-)-rich beetroot juice (NT+BR)...
December 1, 2016: Journal of Applied Physiology
https://www.readbyqxmd.com/read/27909094/a-case-of-exertional-rhabdomyolysis-a-cheer-for-standardizing-inpatient-management-and-prevention
#4
Youyang Yang, Lindsay P Carter, Rebecca E Cook, Elahna Paul, Kevin R Schwartz
No abstract text is available yet for this article.
December 2016: Hospital Pediatrics
https://www.readbyqxmd.com/read/27894069/association-between-left-atrial-dilatation-and-invasive-hemodynamics-at-rest-and-during-exercise-in-asymptomatic-aortic-stenosis
#5
Nicolaj Lyhne Christensen, Jordi Sanchez Dahl, Rasmus Carter-Storch, Rine Bakkestrøm, Kurt Jensen, Flemming Hald Steffensen, Eva Vad Søndergaard, Lars Videbæk, Jacob Eifer Møller
BACKGROUND: Transition from an asymptomatic to symptomatic state in severe aortic stenosis is often difficult to assess. Identification of a morphological sign of increased hemodynamic load may be important in asymptomatic aortic stenosis to identify patients at risk. METHODS AND RESULTS: Thirty-nine patients with asymptomatic severe aortic stenosis (aortic valve area <1 cm(2), peak jet velocity >3.5 m/s) underwent exercise testing with simultaneous invasive hemodynamic monitoring and Doppler echocardiography...
October 2016: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/27893060/association-between-allergen-exposure-in-inner-city-schools-and-asthma-morbidity-among-students
#6
William J Sheehan, Perdita Permaul, Carter R Petty, Brent A Coull, Sachin N Baxi, Jonathan M Gaffin, Peggy S Lai, Diane R Gold, Wanda Phipatanakul
Importance: Home aeroallergen exposure is associated with increased asthma morbidity in children, yet little is known about the contribution of school aeroallergen exposures to such morbidity. Objective: To evaluate the effect of school-specific aeroallergen exposures on asthma morbidity among students, adjusting for home exposures. Design, Setting, and Participants: The School Inner-City Asthma Study was a prospective cohort study evaluating 284 students aged 4 to 13 years with asthma who were enrolled from 37 inner-city elementary schools in the northeastern United States between March 1, 2008, and August 31, 2013...
November 21, 2016: JAMA Pediatrics
https://www.readbyqxmd.com/read/27890798/performance-of-the-subcutaneous-implantable-defibrillator-in-primary-prevention-patients-with-and-without-reduced-ejection-fraction-versus-secondary-prevention-patients
#7
Lucas Boersma, Craig S Barr, Martin C Burke, Angel R Leon, Dominic A Theuns, John M Herre, Raul Weiss, Mark S Kremers, Petr Neuzil, Michael P Husby, Nathan Carter, Timothy M Stivland, Michael R Gold
BACKGROUND: The subcutaneous implantable defibrillator (S-ICD) provides an alternative to the transvenous ICD (TV-ICD) for prevention of sudden cardiac death (SCD), but has not been well studied in the most commonly treated TV-ICD patient population, namely primary prevention (PP) patients with left ventricular (LV) dysfunction. OBJECTIVE: These analyses were designed to compare clinical outcomes for PP patients with and without a reduced ejection fraction (EF) and secondary prevention (SP) patients implanted with the S-ICD...
November 24, 2016: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/27882555/a-randomized-controlled-pilot-study-of-vo2-max-testing-a-potential-model-for-measuring-relative-in-vivo-efficacy-of-different-red-blood-cell-products
#8
Elliott Bennett-Guerrero, Evelyn L Lockhart, Nicholas Bandarenko, Mary L Campbell, Michael J Natoli, Veronika K Jamnik, Timothy R Carter, Richard E Moon
BACKGROUND: Randomized trials, for example, RECESS, comparing "young" (median, 7-day) versus "middle-aged" (median, 28-day) red blood cells (RBCs), showed no difference in outcome. These data are important; however, they do not inform us about the safety and effectiveness of the oldest RBCs, which some patients receive. It may not be feasible to conduct a clinical trial randomizing patients to receive the oldest blood. Therefore, we propose strenuous exercise (VO2 max testing) as a model to study the relative efficacy to increase oxygen delivery to tissue of different RBC products, for example, extremes of storage duration...
November 23, 2016: Transfusion
https://www.readbyqxmd.com/read/27879562/effects-of-transport-temperature-on-the-stability-of-inflammatory-hemostasis-endothelial-function-and-oxidative-stress-plasma-biomarker-concentrations
#9
Octavia M Peck Palmer, Melinda Carter, Chung-Chou H Chang, Nicole Lucko, Vanessa M Jackson, Qian Sun, Xinyan Xie, Melanie Scott, John A Kellum, Arvind Venkat, Sachin Yende
BACKGROUND: A number of studies in critically ill patients are conducted outside the hospital. Specimens should ideally be transported from out-of-hospital setting to a laboratory using dry ice, but this approach is expensive and may not be feasible in some circumstances. We, therefore, examined the impact of temperature during transport of specimens on the precision of biomarker concentrations. OBJECTIVE: To determine the effects of transport temperature conditions on biomarker concentrations in specimens processed within 1 hour of collection...
November 22, 2016: Shock
https://www.readbyqxmd.com/read/27872354/integrating-maternal-mental-health-care-in-the-pediatric-medical-home-treatment-engagement-and-child-outcomes
#10
Mary C Kimmel, Rheanna E Platt, Danielle N Steinberg, Fallon Cluxton-Keller, Lauren M Osborne, Tracy Carter, Jennifer L Payne, Barry S Solomon
Maternal depression is associated with an array of poor child health outcomes, and low-income women face many barriers to accessing treatment. In this pilot study, we assessed treatment engagement in a maternal mental health clinic staffed by a case manager and psychiatrist in an urban pediatric practice. We also examined factors associated with engagement as well as child health outcomes and health care use. Nearly half of the women enrolled attended at least 4 sessions with a psychiatrist in 6 months. Text messaging with the case manager was associated with a greater compliance with psychiatrist sessions...
November 20, 2016: Clinical Pediatrics
https://www.readbyqxmd.com/read/27871459/morphology-histochemistry-and-glycosylation-of-the-placenta-and-associated-tissues-in-the-european-hedgehog-erinaceus-europaeus
#11
Carolyn J P Jones, A M Carter, W R Allen, Sandra A Wilsher
INTRODUCTION: There are few descriptions of the placenta and associated tissues of the European hedgehog (Erinaceus europaeus) and here we present findings on a near-term pregnant specimen. METHODS: Tissues were examined grossly and then formalin fixed and wax-embedded for histology and immunocytochemistry (cytokeratin) and resin embedded for lectin histochemistry. RESULTS: Each of four well-developed and near term hoglets displayed a discoid, haemochorial placenta with typical labyrinth and spongy zones...
December 2016: Placenta
https://www.readbyqxmd.com/read/27869802/molecular-analysis-of-circulating-tumor-cells-identifies-distinct-copy-number-profiles-in-patients-with-chemosensitive-and-chemorefractory-small-cell-lung-cancer
#12
Louise Carter, Dominic G Rothwell, Barbara Mesquita, Christopher Smowton, Hui Sun Leong, Fabiola Fernandez-Gutierrez, Yaoyong Li, Deborah J Burt, Jenny Antonello, Christopher J Morrow, Cassandra L Hodgkinson, Karen Morris, Lynsey Priest, Mathew Carter, Crispin Miller, Andrew Hughes, Fiona Blackhall, Caroline Dive, Ged Brady
In most patients with small-cell lung cancer (SCLC)-a metastatic, aggressive disease-the condition is initially chemosensitive but then relapses with acquired chemoresistance. In a minority of patients, however, relapse occurs within 3 months of initial treatment; in these cases, disease is defined as chemorefractory. The molecular mechanisms that differentiate chemosensitive from chemorefractory disease are currently unknown. To identify genetic features that distinguish chemosensitive from chemorefractory disease, we examined copy-number aberrations (CNAs) in circulating tumor cells (CTCs) from pretreatment SCLC blood samples...
November 21, 2016: Nature Medicine
https://www.readbyqxmd.com/read/27868196/differential-regulation-of-blood-flow-induced-neovascularisation-and-mural-cell-recruitment-by-vegf-and-angiopoietin-signalling
#13
Oliver A Stone, James G Carter, P Charles Lin, Ewa Paleolog, Maria J C Machado, David O Bates
Signalling through VEGF receptors and the Tie2 receptor by angiopoietins is required in combination with blood flow for the formation of a functional vascular network. We tested the hypothesis that VEGF and Ang1 contribute differentially to neovascularization induced by nitric oxide (NO) mediated vasodilatation, by comparing the phenotype of new microvessels in the mesentery during induction of vascular remodelling by over-expression of endothelial nitric oxide synthase (eNOS) in the fat pad of the adult rat mesentery during inhibition of Angiopoietin signalling with soluble Tie2 and VEGF signalling with sFlt1...
November 21, 2016: Journal of Physiology
https://www.readbyqxmd.com/read/27868156/vaginal-and-sexual-health-treatment-strategies-within-a-female-sexual-medicine-program-for-cancer-patients-and-survivors
#14
Jeanne Carter, Cara Stabile, Barbara Seidel, Raymond E Baser, Shari Goldfarb, Deborah J Goldfrank
PURPOSE: We sought to evaluate patient adherence and response to simple vaginal and sexual health treatment strategies in female cancer patients receiving treatment at a female sexual medicine and health program and identify improvements of physical symptoms, per patient and clinical evaluation. METHODS: Evaluability criteria included gynecologic exam at initial visit, at least one follow-up with gynecologic exam within 8 months of initial visit, and all consecutive follow-ups <6 months apart...
November 21, 2016: Journal of Cancer Survivorship: Research and Practice
https://www.readbyqxmd.com/read/27867438/total-sleep-deprivation-and-pain-perception-during-cold-noxious-stimuli-in-humans
#15
Robert A Larson, Jason R Carter
BACKGROUND AND AIMS: A substantial portion of the population suffers from chronic pain leading to significant health care costs and lost productivity. Loss of sleep duration and quality are widely reported in patients suffering from a variety of acute or chronic pain conditions. Conversely, sleep loss has been known to elevate pain perception; thus a potential bi-directional relationship exists between sleep deprivation and pain. To date, the majority of studies examining the relationship between experimentally induced pain and sleep loss have focused on the measurement of pain threshold...
October 2016: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/27863180/the-underuse-of-methotrexate-in-the-treatment-of-ra-a-national-analysis-of-prescribing-practices-in-the-u-s
#16
Melanie K Rohr, Ted R Mikuls, Stanley B Cohen, Carter J Thorne, James R O'Dell
OBJECTIVE: Methotrexate (MTX) is the anchor drug in the treatment of rheumatoid arthritis (RA) due to its effectiveness, tolerability, and cost. This study examines MTX prescribing practices in the US from 2009 to 2014. METHODS: Symphony Health Solutions which covers 274 million patients in the US was used to identify patients diagnosed with RA who were naïve to MTX in 2009 and 2012. Data was collected including medication use and doses, demographics, and medical co-morbidities...
November 18, 2016: Arthritis Care & Research
https://www.readbyqxmd.com/read/27859041/increased-subcortical-oligodendroglia-like-cells-in-pharmacoresistant-focal-epilepsy-in-children-correlate-with-extensive-epileptogenic-zones
#17
Satoru Sakuma, William C Halliday, Ruka Nomura, Shiro Baba, Yosuke Sato, Kazuo Okanari, Midori Nakajima, Elysa Widjaja, Cyrus Boelman, Ayako Ochi, O Carter Snead, James T Rutka, James Drake, Steven Miller, Hiroshi Otsubo
OBJECTIVE: Cortical resections in epilepsy surgery tend to involve multiple lobes in children, compared to adults, partly due to underlying pathology. Oligodendroglia-like cells (OLCs) have been observed in surgical specimens from children with pharmacoresistant epilepsy. We hypothesize that OLCs recruit multiple-lobe epileptogenic zones in pediatric pharmacoresistant focal epilepsy. METHODS: We examined the surgical specimens from 30 children who underwent epilepsy surgery (1...
November 8, 2016: Epilepsia
https://www.readbyqxmd.com/read/27856273/hypermutation-in-pancreatic-cancer
#18
Jeremy L Humphris, Ann-Marie Patch, Katia Nones, Peter J Bailey, Amber L Johns, Skye McKay, David K Chang, David K Miller, Marina Pajic, Karin S Kassahn, Michael C J Quinn, Timothy J C Bruxner, Angelika N Christ, Ivon Harliwong, Senel Idrisoglu, Suzanne Manning, Craig Nourse, Ehsan Nourbakhsh, Andrew Stone, Peter J Wilson, Matthew Anderson, J Lynn Fink, Oliver Holmes, Stephen Kazakoff, Conrad Leonard, Felicity Newell, Nick Waddell, Scott Wood, Ronald S Mead, Qinying Xu, Jianmin Wu, Mark Pinese, Mark J Cowley, Marc D Jones, Adnan M Nagrial, Venessa T Chin, Lorraine A Chantrill, Amanda Mawson, Angela Chou, Christopher J Scarlett, Andreia V Pinho, Ilse Rooman, Marc Giry-Laterriere, Jaswinder S Samra, James G Kench, Neil D Merrett, Christopher W Toon, Krishna Epari, Nam Q Nguyen, Andrew Barbour, Nikolajs Zeps, Nigel B Jamieson, Colin J McKay, C Ross Carter, Euan J Dickson, Janet S Graham, Fraser Duthie, Karin Oien, Jane Hair, Jennifer P Morton, Owen J Sansom, Robert Grützmann, Ralph H Hruban, Anirban Maitra, Christine A Iacobuzio-Donahue, Richard D Schulick, Christopher L Wolfgang, Richard A Morgan, Rita T Lawlor, Borislav Rusev, Vincenzo Corbo, Roberto Salvia, Ivana Cataldo, Giampaolo Tortora, Margaret A Tempero, Oliver Hofmann, James R Eshleman, Christian Pilarsky, Aldo Scarpa, Elizabeth A Musgrove, Anthony J Gill, John V Pearson, Sean M Grimmond, Nicola Waddell, Andrew V Biankin
Pancreatic cancer is molecularly diverse, with few effective therapies. Increased mutation burden and defective DNA repair are associated with response to immune checkpoint inhibitors in several other cancer types. We interrogated 385 pancreatic cancer genomes to define hypermutation and its causes. Mutational signatures inferring defects in DNA repair were enriched in those with the highest mutation burdens. Mismatch repair deficiency was identified in 1% of tumors harboring different mechanisms of somatic inactivation of MLH1 and MSH2...
November 15, 2016: Gastroenterology
https://www.readbyqxmd.com/read/27854530/the-impact-of-michigan-s-partial-repeal-of-the-universal-motorcycle-helmet-law-on-helmet-use-fatalities-and-head-injuries
#19
Patrick M Carter, Lisa Buckley, Carol A C Flannagan, Jessica B Cicchino, Mark Hemmila, Patrick J Bowman, Farideh Almani, C Raymond Bingham
OBJECTIVES: To evaluate the impact of the partial repeal of Michigan's universal motorcycle helmet law on helmet use, fatalities, and head injuries. METHODS: We compared helmet use rates and motorcycle crash fatality risk for the 12 months before and after the April 13, 2012, repeal with a statewide police-reported crash data set. We linked police-reported crashes to injured riders in a statewide trauma registry. We compared head injury before and after the repeal...
November 17, 2016: American Journal of Public Health
https://www.readbyqxmd.com/read/27836708/the-real-time-fmri-neurofeedback-based-stratification-of-default-network-regulation-neuroimaging-data-repository
#20
Amalia R McDonald, Jordan Muraskin, Nicholas T Van Dam, Caroline Froehlich, Benjamin Puccio, John Pellman, Clemens C C Bauer, Alexis Akeyson, Melissa M Breland, Vince D Calhoun, Steven Carter, Tiffany P Chang, Chelsea Gessner, Alyssa Gianonne, Steven Giavasis, Jamie Glass, Steven Homann, Margaret King, Melissa Kramer, Drew Landis, Alexis Lieval, Jonathan Lisinski, Anna Mackay-Brandt, Brittny Miller, Laura Panek, Hayley Reed, Christine Santiago, Eszter Schoell, Richard Sinnig, Melissa Sital, Elise Taverna, Russell Tobe, Kristin Trautman, Betty Varghese, Lauren Walden, Runtang Wang, Abigail B Waters, Dylan C Wood, F Xavier Castellanos, Bennett Leventhal, Stanley J Colcombe, Stephen LaConte, Michael P Milham, R Cameron Craddock
This data descriptor describes a repository of openly shared data from an experiment to assess inter-individual differences in default mode network (DMN) activity. This repository includes cross-sectional functional magnetic resonance imaging (fMRI) data from the Multi Source Interference Task, to assess DMN deactivation, the Moral Dilemma Task, to assess DMN activation, a resting state fMRI scan, and a DMN neurofeedback paradigm, to assess DMN modulation, along with accompanying behavioral and cognitive measures...
November 9, 2016: NeuroImage
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