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Xingqi Chen, Ying Shen, Will Draper, Jason D Buenrostro, Ulrike Litzenburger, Seung Woo Cho, Ansuman T Satpathy, Ava C Carter, Rajarshi P Ghosh, Alexandra East-Seletsky, Jennifer A Doudna, William J Greenleaf, Jan T Liphardt, Howard Y Chang
Spatial organization of the genome plays a central role in gene expression, DNA replication, and repair. But current epigenomic approaches largely map DNA regulatory elements outside of the native context of the nucleus. Here we report assay of transposase-accessible chromatin with visualization (ATAC-see), a transposase-mediated imaging technology that employs direct imaging of the accessible genome in situ, cell sorting, and deep sequencing to reveal the identity of the imaged elements. ATAC-see revealed the cell-type-specific spatial organization of the accessible genome and the coordinated process of neutrophil chromatin extrusion, termed NETosis...
October 17, 2016: Nature Methods
C D Hoppe, J E Cade, M Carter
BACKGROUND: Mobile applications (apps) could support diabetes management through dietary, weight and blood glucose self-monitoring, as well as by promoting behaviour change. The present study aimed to evaluate diabetes apps for content, functions and behaviour change techniques (BCTs). METHODS: Diabetes self-management apps for Android smartphones were searched for on the Google Play Store. Ten apps each from the following search terms were included; 'diabetes', 'diabetes type 1', 'diabetes type 2', 'gestational diabetes'...
October 17, 2016: Journal of Human Nutrition and Dietetics: the Official Journal of the British Dietetic Association
E B Carter, M G Tuuli, A O Odibo, G A Macones, A G Cahill
OBJECTIVE: To investigate the association between the number of prenatal visits (PNVs) and pregnancy outcomes in women with gestational diabetes (GDM) and Type 2 diabetes mellitus (DM). STUDY DESIGN: A 4-year prospective cohort study of women with GDM and DM and was conducted. Patients ⩾75th percentile for number of PNVs were compared with those ⩽25th percentile. The primary outcomes were large for gestational age (LGA) with birth weight >90% and neonatal intensive care unit (NICU) admission for >24 h...
October 13, 2016: Journal of Perinatology: Official Journal of the California Perinatal Association
Martina Lessio, Christoph Riplinger, Emily A Carter
Adsorbed protons that develop hydride character have been proposed to play a role in the mechanism of CO2 reduction catalyzed by pyridine on GaP photoelectrodes. Investigating their stability represents an important step towards vetting this mechanism. In this contribution, the relative stability of the adsorbed protons is determined using cluster models with dispersion-corrected density functional theory and continuum solvation. Proton acidity constants computed under typical experimental conditions are compared to the acidity constants of other relevant species...
September 29, 2016: Physical Chemistry Chemical Physics: PCCP
Keith Share, Adam P Cohn, Rachel Carter, Bridget Rogers, Cary L Pint
Potassium is an earth abundant alternative to lithium for rechargeable batteries, but a critical limitation in potassium ion battery anodes is the low capacity of KC8 graphite intercalation compounds in comparison to conventional LiC6. Here we demonstrate that nitrogen doping of few-layered graphene can increase the storage capacity of potassium from a theoretical maximum of 278 mAh/g in graphite to over 350 mAh/g, competitive with anode capacity in commercial lithium-ion batteries and the highest reported anode capacity so far for potassium ion batteries...
October 9, 2016: ACS Nano
Keith Share, Adam P Cohn, Rachel E Carter, Cary L Pint
Recently emerging potassium ion (K-ion) batteries offer a lower-cost alternative to lithium-ion batteries while enabling comparably high storage capacity. Here, we leverage the strong Raman spectroscopic response of few-layered graphene to provide the first insight into the electrochemical staging sequence for K(+) ions in graphitic carbons. Our analysis reveals the signature of a dilute stage I compound that precedes formation of ordered intercalation compounds transitioning from stage VI (KC72), stage II (KC24), and stage I (KC8) and correlates electrochemical responses to the stage formation...
September 15, 2016: Nanoscale
R Carter Clement, Caitlin M Gray, Michael M Kheir, Peter B Derman, Rebecca M Speck, L Scott Levin, Lee A Fleisher
BACKGROUND: The Centers for Medicare & Medicaid Services (CMS) recently imposed penalties against hospitals with above-average 30-day readmission rates following total joint arthroplasty (TJA). Hospitals must decide whether investments in readmission prevention are worthwhile. This study examines the financial incentives associated with unplanned readmissions before and after invocation of these penalties. METHODS: Financial data were reviewed for 2028 consecutive primary TJAs performed on Medicare beneficiaries over a 2-year period at an urban academic health system...
August 31, 2016: Journal of Arthroplasty
Jennifer B Manders, Henry M Kuerer, Benjamin D Smith, Cornelia McCluskey, William B Farrar, Thomas G Frazier, Linna Li, Charles E Leonard, Dennis L Carter, Sheema Chawla, Lori E Medeiros, J Michael Guenther, Lauren E Castellini, Daniel J Buchholz, Eleftherios P Mamounas, Irene L Wapnir, Kathleen C Horst, Anees Chagpar, Suzanne B Evans, Adam I Riker, Faisal S Vali, Lawrence J Solin, Lisa Jablon, Abram Recht, Ranjna Sharma, Ruixiao Lu, Amy P Sing, E Shelley Hwang, Julia White
OBJECTIVE: The aim of this study was to determine the impact of the results of the 12-gene DCIS Score assay on (i) radiotherapy recommendations for patients with pure ductal carcinoma in situ (DCIS) following breast-conserving surgery (BCS), and (ii) patient decisional conflict and state anxiety. METHODS: Thirteen sites across the US enrolled patients (March 2014-August 2015) with pure DCIS undergoing BCS. Prospectively collected data included clinicopathologic factors, physician estimates of local recurrence risk, DCIS Score results, and pre-/post-assay radiotherapy recommendations for each patient made by a surgeon and a radiation oncologist...
October 4, 2016: Annals of Surgical Oncology
Reyaud Rahman, Maria Jesus Sanchez Martin, Shamdeo Persaud, Nicolas Ceron, Dwayne Kellman, Lise Musset, Keith H Carter, Pascal Ringwald
Because of concerns about possible emergence of artemisinin resistance strains of Plasmodium falciparum in mining areas of the interior of Guyana, a 7-day artesunate trial was conducted from March to December 2014. The day-3 parasite clearance rate, the efficacy of artesunate at day 28, and polymorphism of Kelch 13 (PfK13)-the marker of artemisinin resistance-were assessed. The study confirmed the continued sensitivity of P falciparum to artemisinin. A 7-day course of artesunate was 100% efficacious with only 2% (95% confidence interval, ...
September 2016: Open Forum Infectious Diseases
Yana Davidov, Bella Ungar, Haggai Bar Yoseph, Dan Carter, Ola Haj-Natour, Miri Yavzori, Yehuda Chowers, Rami Eliakim, Shomron BenHorin, Uri Kopylov
BACKGROUND: The association of infliximab (IFX) trough levels with clinical and endoscopic outcomes in inflammatory bowel disease is well established. However there is scarce data regarding the association of perianal fistula response with IFX. The aim of the study was to establish whether early induction infliximab levels and anti-infliximab antibodies (ATI) are associated with perianal fistula response. METHODS: Consecutive CD patients with perianal fistulae that were treated with IFX between 2008 and 2016 were included in the study...
October 4, 2016: Journal of Crohn's & Colitis
Jie Fu, Wan-Ning Lee, Clark Coleman, Melissa Meyer, Jason Carter, Kirk Nowack, Ching-Hua Huang
A pilot study employing two parallel trains of two-stage biofiltration, i.e., a sand/anthracite (SA) biofilter followed by a biologically-active granular activated carbon (GAC) contactor, was conducted to test the efficiency, feasibility and stability of biofiltration for removing natural organic matter (NOM) after coagulation in a drinking water treatment plant. Results showed the biofiltration process could effectively remove turbidity (<0.1 NTU in all effluents) and NOM (>24% of dissolved organic carbon (DOC), >57% of UV254, and >44% of SUVA254), where the SA biofilters showed a strong capacity for turbidity removal, while the GAC contactors played the dominant role in NOM removal...
January 2017: Chemosphere
Duaa Alsulaiman, Katelyn Sylvester, Craig Stevens, Danielle Carter
Background: For patients on continuous IV unfractionated heparin (UFH), failing to achieve a therapeutic aPTT by 24 hours can be associated with increased morbidity. A pharmacy clinical surveillance system (PCSS) subtherapeutic aPTT alert was implemented at our institution to improve achievement of therapeutic aPTT goals by 24 hours. Objective: The primary objective was the time to achieve the minimum goal aPTT before and after the alert implementation. The secondary objectives were to examine the percentage of patients who achieved the minimum goal aPTT by 24 hours and the number of dose changes to achieve the minimum goal aPTT...
September 2016: Hospital Pharmacy
Martha Sedegah, Bjoern Peters, Michael R Hollingdale, Harini D Ganeshan, Jun Huang, Fouzia Farooq, Maria N Belmonte, Arnel D Belmonte, Keith J Limbach, Carter Diggs, Lorraine Soisson, Ilin Chuang, Eileen D Villasante
A DNA prime/adenovirus boost malaria vaccine encoding Plasmodium falciparum strain 3D7 CSP and AMA1 elicited sterile clinical protection associated with CD8+ T cell interferon-gamma (IFN-γ) cells responses directed to HLA class 1-restricted AMA1 epitopes of the vaccine strain 3D7. Since a highly effective malaria vaccine must be broadly protective against multiple P. falciparum strains, we compared these AMA1 epitopes of two P. falciparum strains (7G8 and 3D7), which differ by single amino acid substitutions, in their ability to recall CD8+ T cell activities using ELISpot and flow cytometry/intracellular staining assays...
2016: PloS One
Tohru Okanishi, Tomoyuki Akiyama, Ellen Mayo, Yasunori Honda, Chihiro Ueda-Kawada, Midori Nakajima, Yoichiro Homma, Ayako Ochi, Cristina Go, Elysa Widjaja, Sylvester H Chuang, James T Rutka, James Drake, O Carter Snead, Hiroshi Otsubo
OBJECTIVE: We hypothesized that the extensive epileptic network in patients with tuberous sclerosis complex (TSC) manifests as clustered and scattered distributions of magnetoencephalography spike sources (MEGSS). METHODS: We retrospectively analyzed pre-surgical MEG in 15 patients with TSC. We performed single moving dipole analysis to localize and classify clustered and scattered MEGSS. We compared the number of electrodes within the resected area (RA) and the proportions of clustered and scattered MEGSS within RA with the seizure outcome...
September 6, 2016: Epilepsy Research
Nikhil Tyagi, Sanjeev K Srivastava, Sumit Arora, Yousef Omar, Zohaib Mohammad Ijaz, Ahmed Al-Ghadhban, Sachin K Deshmukh, James E Carter, Ajay P Singh, Seema Singh
Sunscreen formulations containing UVB filters, such as Zinc-oxide (ZnO) and titanium-dioxide (TiO2) nanoparticles (NPs) have been developed to limit the exposure of human skin to UV-radiations. Unfortunately, these UVB protective agents have failed in controlling the skin cancer incidence. We recently demonstrated that silver nanoparticles (Ag-NPs) could serve as novel protective agents against UVB-radiations. Here our goal was to perform comparative analysis of direct and indirect UVB-protection efficacy of ZnO-, TiO2- and Ag-NPs...
September 28, 2016: Cancer Letters
Elisabet E Manasanch, Carlos Fernández de Larrea, Adriana Zingone, Seth M Steinberg, Mary Kwok, Nishant Tageja, Manisha Bhutani, Dickran Kazandjian, Mark Roschewski, Peter Wu, George Carter, Diamond Zuchlinski, Marcia Mulquin, Liz Lamping, Rene Costello, Deborah Burton, Lindsey Gil, William D Figg, Irina Maric, Katherine R Calvo, Constance Yuan, Maryalice Stetler-Stevenson, Neha Korde, Ola Landgren
The proteasome inhibitor carfilzomib is highly effective in the treatment of multiple myeloma. It irreversibly binds the chymotrypsin-like active site in the β5 subunit of the 20S proteasome. Despite impressive response rates when carfilzomib is used in combination with immunomodulatory agents in newly diagnosed multiple myeloma patients; no biomarker exists to accurately predict response and clinical outcomes. We prospectively assessed the activity in peripheral blood of the chymotrypsin-like (CHYM), caspase-like (CASP) and trypsin-like (TRYP) proteolytic sites in 45 newly diagnosed multiple myeloma patients treated with eight cycles of carfilzomib, lenalidomide and dexamethasone (CRd) (NCT01402284)...
August 9, 2016: Leukemia & Lymphoma
Ashley N Carter, Penny A Ralston, Iris Young-Clark, Jasminka Z Ilich
African Americans have higher risk of developing type 2 diabetes and cardiovascular disease (CVD) compared to other racial groups. Modifiable and non-modifiable factors play a role in the development of both diseases. This study assessed diabetes indicators in relation to other CVD risk factors taking into account confounders, among African American adults. This was a cross-sectional study in mid-life and older African Americans (≥45 years) who were recruited from the local churches. Fasting blood was collected and serum analyzed for diabetes indicators, apolipoproteins, adipokines, and lipid profile...
2016: American Journal of Cardiovascular Disease
Susan E Waisbren, Sanjay P Prabhu, Patricia Greenstein, Carter Petty, Donald Schomer, Vera Anastasoaie, Kalin Charette, Daniel Rodriguez, Sai Merugumala, Alexander P Lin
INTRODUCTION: Researchers hypothesized that in phenylketonuria (PKU) high brain phenylalanine (Phe) levels and low brain tyrosine (Tyr) levels affect neuropsychological functioning. However, traditional magnetic resonance spectroscopy (MRS) yielded uncertain results of brain Phe and could not adequately measure brain Tyr. This pilot study examined the potential of correlated spectroscopy (COSY) to quantify these biomarkers and explain variability in neuropsychological functioning. METHODS: Nine adults with early treated classic PKU received magnetic resonance imaging (MRI) with COSY and a battery of neuropsychological tests...
September 28, 2016: JIMD Reports
S Aggarwal, N D Prionas, J N Carter, P Pradhan, J L Bui, R von Eyben, C K Ho, S L Hancock, S G Soltys, A C Koong, D T Chang
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
S K M Lau, K Patel, T Kim, E Knipprath, G Y Kim, L I Cervino, J D Lawson, K T Murphy, P Sanghvi, B S Carter, C Chen
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
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