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https://www.readbyqxmd.com/read/29142246/a-comprehensive-structural-biochemical-and-biological-profiling-of-the-human-nudix-hydrolase-family
#1
Jordi Carreras-Puigvert, Marinka Zitnik, Ann-Sofie Jemth, Megan Carter, Judith E Unterlass, Björn Hallström, Olga Loseva, Zhir Karem, José Manuel Calderón-Montaño, Cecilia Lindskog, Per-Henrik Edqvist, Damian J Matuszewski, Hammou Ait Blal, Ronnie P A Berntsson, Maria Häggblad, Ulf Martens, Matthew Studham, Bo Lundgren, Carolina Wählby, Erik L L Sonnhammer, Emma Lundberg, Pål Stenmark, Blaz Zupan, Thomas Helleday
The NUDIX enzymes are involved in cellular metabolism and homeostasis, as well as mRNA processing. Although highly conserved throughout all organisms, their biological roles and biochemical redundancies remain largely unclear. To address this, we globally resolve their individual properties and inter-relationships. We purify 18 of the human NUDIX proteins and screen 52 substrates, providing a substrate redundancy map. Using crystal structures, we generate sequence alignment analyses revealing four major structural classes...
November 16, 2017: Nature Communications
https://www.readbyqxmd.com/read/29125904/early-rheumatoid-arthritis-presentation-treatment-and-outcomes-in-aboriginal-patients-in-canada-a-canadian-early-arthritis-cohort-study-analysis
#2
Sujay Nagaraj, Cheryl Barnabe, Orit Schieir, Janet Pope, Susan J Bartlett, Gilles Boire, Edward Keystone, Diane Tin, Boulos Haraoui, J Carter Thorne, Vivian P Bykerk, Carol Hitchon
OBJECTIVE: Health inequities exist in chronic diseases for Aboriginal people. This study compared early rheumatoid arthritis (ERA) presentation, treatment and outcomes between Aboriginal and Caucasian patients in a large Canadian cohort study. METHODS: Longitudinal data from the Canadian early ArThritis CoHort (CATCH), a prospective multicenter ERA study, were analyzed for participants who self-identified as Aboriginal or Caucasian ethnicity. Disease characteristics at presentation, prognostic factors, frequency of remission and disease-modifying therapy strategies were contrasted between population groups...
November 10, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/29125331/-18-fdg-pet-ct-is-useful-in-the-follow-up-of-surgically-treated-patients-with-esophageal-adenocarcinoma
#3
Sonia L Betancourt-Cuellar, Diana P Palacio, Carol C Wu, Brett W Carter, Arlene M Correa, Wayne L Hofstetter, Edith M Marom
PURPOSE: The purpose of this study was to evaluate FDG- PET/CT's performance in the follow-up of patients with surgically treated esophageal adenocarcinoma. MATERIAL AND METHODS: The follow-up FDG-PET/CT scans of 162 consecutive patients with surgically treated esophageal adenocarcinoma were retrospectively reviewed. Histopathological and/or imaging examinations confirmed recurrent disease. The accuracy, sensitivity, specificity, and negative and positive predictive values were calculated...
November 10, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/29124910/missing-pieces-of-the-puzzle-to-effectively-control-digital-dermatitis
#4
K Orsel, P Plummer, J Shearer, J De Buck, S D Carter, R Guatteo, H W Barkema
Since the first report of bovine digital dermatitis (DD) in 1974, there is a large body of the literature published; however, effective prevention and control of the disease remain elusive. Although many aspects of the pathogenesis of DD have been investigated, even some of the most basic questions such as the aetiology of this disease remain under debate. Treponema spp. have been strongly associated with DD lesions and occur in abundance in advanced lesions; however, efforts to induce disease with pure cultures of these organisms have been largely underwhelming and inconsistent...
November 10, 2017: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/29124882/the-prevalence-of-back-pain-in-patients-in-one-australian-tertiary-hospital-population
#5
Diane Dennis, Brigitte Tampin, Angela Jacques, Tracy Hebden-Todd, Vicki Carter, Michelle McLintock, Elizabeth Hurn, Ian Cooper
OBJECTIVES: The aims of the present study were to provide back pain (BP) point prevalence data from inpatients at an Australian tertiary hospital on one day, and compare this with Australian non-hospitalized population prevalence data; to collect data around the development of BP throughout hospital admission; and to analyse the association between BP and past history of BP, gender, age, admission specialty and hospital length of stay (LOS). METHODS: This was a single-site, prospective, observational study of hospitalized inpatients on one day during 2016, with a subsequent survey over the following 11 days (unless discharge or death occurred sooner)...
November 10, 2017: Musculoskeletal Care
https://www.readbyqxmd.com/read/29121338/efficacy-of-%C3%AE-mannanase-on-broiler-growth-performance-and-energy-utilization-in-the-presence-of-increasing-dietary-galactomannan
#6
R E Latham, M P Williams, H G Walters, B Carter, J T Lee
An experiment was conducted to investigate the impact of β-mannanase inclusion on growth performance, viscosity, and energy utilization in broilers fed diets varying in galactomannan (GM) concentrations. Treatments were arranged as a 3 (GM concentration) × 3 (β-mannanase inclusion) factorial randomized complete block design with 12 replicates of 29 male broilers per replicate for a 42-d experiment. Efforts were made to reduce the amount of soybean meal, and thus GM, in the basal diet with guar gum included at 0, 0...
November 7, 2017: Poultry Science
https://www.readbyqxmd.com/read/29119293/asparaginase-erwinia-chrysanthemi-effectively-depletes-plasma-glutamine-in-adult-patients-with-relapsed-refractory-acute-myeloid-leukemia
#7
Ashkan Emadi, Jennie Y Law, Erin T Strovel, Rena G Lapidus, Linda J B Jeng, Myounghee Lee, Miriam G Blitzer, Brandon A Carter-Cooper, Danielle Sewell, Isabella Van Der Merwe, Sunita Philip, Mohammad Imran, Stephen L Yu, Hongxia Li, Philip C Amrein, Vu H Duong, Edward A Sausville, Maria R Baer, Amir T Fathi, Zeba Singh, Søren M Bentzen
Depletion of glutamine (Gln) has emerged as a potential therapeutic approach in the treatment of acute myeloid leukemia (AML), as neoplastic cells require Gln for synthesis of cellular components essential for survival. Asparaginases deplete Gln, and asparaginase derived from Erwinia chrysanthemi (Erwinaze) appears to have the greatest glutaminase activity of the available asparaginases. In this Phase I study, we sought to determine the dose of Erwinaze that safely and effectively depletes plasma Gln levels to ≤ 120 μmol/L in patients with relapsed or refractory (R/R) AML...
November 8, 2017: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/29117940/etv4-facilitates-cell-cycle-progression-in-pancreatic-cells-through-transcriptional-regulation-of-cyclin-d1
#8
Nikhil Tyagi, Sachin K Deshmukh, Sanjeev K Srivastava, Shafquat Azim, Aamir Ahmad, Ahmed Al-Ghadhban, Ajay P Singh, James E Carter, Bin Wang, Seema Singh
The ETS family transcription factor ETV4 is aberrantly expressed in a variety of human tumors and plays an important role in carcinogenesis through upregulation of relevant target gene expression. Here, it is demonstrated that ETV4 is overexpressed in pancreatic cancer (PC) tissues as compared to the normal pancreas, and is associated with enhanced growth and rapid cell cycle progression of PC cells. ETV4 expression was silenced through stable expression of a specific short-interfering hairpin RNA (shRNA) in two PC cell lines (ASPC1 and Colo357), while it was ectopically expressed in BXPC3 cells...
November 8, 2017: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/29107117/burnout-and-stress-among-us-surgery-residents-psychological-distress-and-resilience
#9
Carter C Lebares, Ekaterina V Guvva, Nancy L Ascher, Patricia S O'Sullivan, Hobart W Harris, Elissa S Epel
BACKGROUND: Burnout among physicians affects mental health, performance and patient outcomes. Surgery residency is a high-risk time for burnout. We examined burnout and the psychological characteristics that may contribute to burnout vulnerability and resilience in a group of surgical trainees. STUDY DESIGN: An online survey was distributed in September, 2016, to all ACGME-accredited general surgery programs. Burnout was assessed with an abbreviated Maslach Burnout Inventory...
October 24, 2017: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/29102759/preclinical-profile-of-a-dopamine-d1-potentiator-suggests-therapeutic-utility-in-neurological-and-psychiatric-disorders
#10
Robert F Bruns, Stephen N Mitchell, Keith A Wafford, Alex J Harper, Elaine A Shanks, Guy Carter, Michael J O'Neill, Tracey K Murray, Brian J Eastwood, John M Schaus, James P Beck, Junliang Hao, Jeffrey M Witkin, Xia Li, Eyassu Chernet, Jason S Katner, Hong Wang, John W Ryder, Meghane E Masquelin, Linda K Thompson, Patrick L Love, Deanna L Maren, Julie F Falcone, Michelle M Menezes, Linli Zhang, Charles R Yang, Kjell A Svensson
DETQ, an allosteric potentiator of the dopamine D1 receptor, was tested in therapeutic models that were known to respond to D1 agonists. Because of a species difference in affinity for DETQ, all rodent experiments used transgenic mice expressing the human D1 receptor (hD1 mice). When given alone, DETQ reversed the locomotor depression caused by a low dose of reserpine. DETQ also acted synergistically with L-DOPA to reverse the strong hypokinesia seen with a higher dose of reserpine. These results indicate potential as both monotherapy and adjunct treatment in Parkinson's disease...
October 26, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/29099940/long-term-colonisation-by-campylobacter-jejuni-within-a-human-host-evolution-antimicrobial-resistance-and-adaptation
#11
Samuel J Bloomfield, Anne C Midwinter, Patrick J Biggs, Nigel P French, Jonathan C Marshall, David T S Hayman, Philip E Carter, Craig Thornley, Rudyard Yap, Jackie Benschop
Background: Campylobacteriosis is inflammation of the gastrointestinal tract as a result of Campylobacter infection. Most campylobacteriosis cases are acute and self-limiting, with Campylobacter excretion ceasing a few weeks after symptoms cease. We identified a patient who had tested faecally-positive for Campylobacter jejuni (ST45), intermittently for ten years. Methods: Sixteen Campylobacter isolates were collected from the patient from 2006-2016. The isolates' genomes were sequenced to determine their relatedness, and their antimicrobial susceptibility patterns and motility were measured to determine the effects of antibiotic therapy and long-term excretion on the Campylobacter...
November 1, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29095771/the-3-m-backwards-walk-and-retrospective-falls-diagnostic-accuracy-of-a-novel-clinical-measure
#12
Valerie Carter, Tarang Jain, Jodi James, Mark Cornwall, Anne Aldrich, Hendrik D de Heer
BACKGROUND AND PURPOSE: Several measures of fall risk have been previously developed and include forward walking, turning, and stepping motions. However, recent research has demonstrated that backwards walking is more sensitive at identifying age-related changes in mobility and balance compared with forward walking. No clinical test of backwards walking currently exists. Therefore, this article describes a novel clinical test of backwards walking, the 3-m backwards walk (3MBW), and assessed whether it was associated with 1-year retrospective falls in a population of healthy older adults...
November 1, 2017: Journal of Geriatric Physical Therapy
https://www.readbyqxmd.com/read/29094067/comorbidities-confounding-the-outcomes-of-surgery-for-third-window-syndrome-outlier-analysis
#13
P Ashley Wackym, Heather T Mackay-Promitas, Shaban Demirel, Gerard J Gianoli, Martin S Gizzi, Dale M Carter, David A Siker
Objective: Patients with third window syndrome and superior semicircular canal dehiscence (SSCD) symptoms whose surgical outcomes placed them as outliers were systematically studied to determine comorbidities that were responsible for their poor outcomes due to these confounding factors. Study Design: Observational analytic case-control study in a tertiary referral center. Methods: Twelve adult patients with clinical SSCD syndrome underwent surgical management and had outcomes that did not resolve all of their subjective symptoms...
October 2017: Laryngoscope Investigative Otolaryngology
https://www.readbyqxmd.com/read/29090365/cd56-immune-cell-infiltration-and-mica-are-decreased-in-breast-lobules-with-fibrocystic-changes
#14
Daniel Kerekes, Daniel W Visscher, Tanya L Hoskin, Derek C Radisky, Rushin D Brahmbhatt, Alvaro Pena, Marlene H Frost, Muhammad Arshad, Melody Stallings-Mann, Stacey J Winham, Linda Murphy, Lori Denison, Jodi M Carter, Keith L Knutson, Amy C Degnim
PURPOSE: While the role of natural killer (NK) cells in breast cancer therapy has been investigated, little information is known about NK cell function and presence in nonmalignant and premalignant breast tissue. Here, we investigate and quantify NK cell marker CD56 and activating ligand MICA in breast tissue with benign breast disease. METHODS: Serial tissue sections from 88 subjects, 44 with benign breast disease (BBD) who remained cancer-free, and 44 with BBD who later developed cancer, were stained with H&E, anti-MICA, and anti-CD56...
November 1, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29089578/producing-coral-offspring-with-cryopreserved-sperm-a-tool-for-coral-reef-restoration
#15
Mary Hagedorn, Virginia L Carter, E Michael Henley, Madeleine J H van Oppen, Rebecca Hobbs, Rebecca E Spindler
Cryopreservation is an important conservation tool, which may help reef-building coral survive. However, scaling-up from small, laboratory-sized experiments to higher-throughput restoration is a major challenge. To be an effective restoration tool, the cryopreservation methods and husbandry to produce new offspring must be defined. This study examined small and larger-scale in vitro reproduction and settlement for Acropora tenuis and Acropora millepora and found that: 1) cryopreservation of coral sperm reduced sperm motility and fertilization success in half, thus fresh sperm, capable of becoming highly motile, is key; 2) the sperm-to-egg ratio and the concentration of the cryoprotectant treatments affected fertilization success in small- and larger-scale reproduction trials using cryopreserved sperm (p < 0...
October 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29089334/ibat-sympathetic-innervation-is-not-required-for-body-weight-loss-induced-by-central-leptin-delivery
#16
Isabelle Cote, Yasemin Sakarya, Sara M Green, Drake Morgan, Christy S Carter, Nihal Tumer, Philip J Scarpace
We evaluated the contribution of brown adipose tissue (BAT) sympathetic innervation on central leptin mediated weight loss. In a short and long-term study, F344BN rats submitted to either a denervation of interscapular BAT (Denervated) or a sham operation (Sham). Animals from each group received Ob (Leptin) or GFP (Control) gene through a single injection of recombinant adeno-associated virus delivered centrally. Changes in body weight were recorded for 14 or 35 days, after which adipose tissues and skeletal muscles were weighed...
October 31, 2017: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29080833/age-related-immune-responses-after-burn-and-inhalation-injury-are-associated-with-altered-clinical-outcomes
#17
John H Frankel, Devin M Boe, Joslyn M Albright, Eileen B O'Halloran, Stewart R Carter, Christopher S Davis, Luis Ramirez, Ellen L Burnham, Richard L Gamelli, Majid Afshar, Elizabeth J Kovacs
This prospective study aimed to address changes in inflammatory response between different aged populations of patients who sustained burn and inhalation injury. Plasma and bronchoalveolar lavage (BAL) samples were collected from 104 patients within 15h of their estimated time of burn injury. Clinical variables, laboratory parameters, and immune mediator profiles were examined in association with clinical outcomes. Older patients were at higher odds for death after burn injury (odds ratio (OR)=7.37 per 10years, p=0...
October 26, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/29079179/genetic-profiles-of-different-subsets-of-merkel-cell-carcinoma-show-links-between-combined-and-pure-mcpyv-negative-tumors
#18
Michael D Carter, Dan Gaston, Weei-Yuarn Huang, Wenda L Greer, Sylvia Pasternak, Thai Yen Ly, Noreen M Walsh
Tumorigenesis in Merkel cell carcinoma (MCC) is driven by (i) clonal integration of the Merkel cell polyomavirus (MCPyV) in neoplastic cells and/or (ii) genetic damage by ultraviolet (UV) light. A higher mutational burden, a UV-mutational signature, and many mutations in the TP53 and RB1 genes characterize the virus-negative subset. MCPyV-negative MCCs include combined (often squamous and neuroendocrine) and pure (neuroendocrine) tumors. Because a combined morphology could elude detection microscopically, we sought a genetic link between combined and pure virus-negative tumors...
October 24, 2017: Human Pathology
https://www.readbyqxmd.com/read/29078773/longitudinal-estimation-of-plasmodium-falciparum-prevalence-in-relation-to-malaria-prevention-measures-in-six-sub-saharan-african-countries
#19
Chris Drakeley, Salim Abdulla, Selidji Todagbe Agnandji, José Francisco Fernandes, Peter Kremsner, Bertrand Lell, Ludovic Mewono, Bache Emmanuel Bache, Michael Gabriel Mihayo, Omar Juma, Marcel Tanner, Marc Christian Tahita, Halidou Tinto, Salou Diallo, Palpouguini Lompo, Umberto D'Alessandro, Bernhards Ogutu, Lucas Otieno, Solomon Otieno, Walter Otieno, Janet Oyieko, Kwaku Poku Asante, Dominic Bon-Ereme Dery, George Adjei, Elisha Adeniji, Dorcas Atibilla, Seth Owusu-Agyei, Brian Greenwood, Samwel Gesase, John Lusingu, Coline Mahende, Robert Mongi, Method Segeja, Samuel Adjei, Tsiri Agbenyega, Alex Agyekum, Daniel Ansong, John Tanko Bawa, Harry Owusu Boateng, Léonard Dandalo, Veronica Escamilla, Irving Hoffman, Peter Maenje, Francis Martinson, Terrell Carter, Didier Leboulleux, David C Kaslow, Effua Usuf, Jean-Yves Pirçon, Edith Roset Bahmanyar
BACKGROUND: Plasmodium falciparum prevalence (PfPR) is a widely used metric for assessing malaria transmission intensity. This study was carried out concurrently with the RTS,S/AS01 candidate malaria vaccine Phase III trial and estimated PfPR over ≤ 4 standardized cross-sectional surveys. METHODS: This epidemiology study (NCT01190202) was conducted in 8 sites from 6 countries (Burkina Faso, Gabon, Ghana, Kenya, Malawi, and Tanzania), between March 2011 and December 2013...
October 27, 2017: Malaria Journal
https://www.readbyqxmd.com/read/29077673/condomless-sex-among-virally-suppressed-women-with-hiv-with-regular-hiv-serodiscordant-sexual-partners-in-the-era-of-treatment-as-prevention
#20
Sophie Patterson, Allison Carter, Valerie Nicholson, Kath Webster, Erin Ding, Mary Kestler, Gina Ogilvie, Alexandra de Pokomandy, Mona Loutfy, Angela Kaida
BACKGROUND: Sexual HIV transmission does not occur with sustained undetectable viral load (VL) on antiretroviral therapy (ART). Awareness of ART prevention benefits and its influence on condom use among women with HIV (WWH) remain unexplored. We estimated prevalence and correlates of condomless sex with regular HIV-serodiscordant partners among WWH with undetectable VL on ART. METHODS: We used baseline questionnaire data from the community-based longitudinal Canadian HIV Women's Sexual and Reproductive Health Cohort Study (CHIWOS)...
December 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
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