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Luisa Quinti, Sharadha Dayalan Naidu, Ulrike Träger, Xiqun Chen, Kimberly Kegel-Gleason, David Llères, Colúm Connolly, Vanita Chopra, Cho Low, Sébastien Moniot, Ellen Sapp, Adelaide R Tousley, Petr Vodicka, Michael J Van Kanegan, Linda S Kaltenbach, Lisa A Crawford, Matthew Fuszard, Maureen Higgins, James R C Miller, Ruth E Farmer, Vijay Potluri, Susanta Samajdar, Lisa Meisel, Ningzhe Zhang, Andrew Snyder, Ross Stein, Steven M Hersch, Lisa M Ellerby, Eranthie Weerapana, Michael A Schwarzschild, Clemens Steegborn, Blair R Leavitt, Alexei Degterev, Sarah J Tabrizi, Donald C Lo, Marian DiFiglia, Leslie M Thompson, Albena T Dinkova-Kostova, Aleksey G Kazantsev
The activity of the transcription factor nuclear factor-erythroid 2 p45-derived factor 2 (NRF2) is orchestrated and amplified through enhanced transcription of antioxidant and antiinflammatory target genes. The present study has characterized a triazole-containing inducer of NRF2 and elucidated the mechanism by which this molecule activates NRF2 signaling. In a highly selective manner, the compound covalently modifies a critical stress-sensor cysteine (C151) of the E3 ligase substrate adaptor protein Kelch-like ECH-associated protein 1 (KEAP1), the primary negative regulator of NRF2...
June 6, 2017: Proceedings of the National Academy of Sciences of the United States of America
B L Loudon, N D Gollop, P R Carter, H Uppal, S Chandran, R Potluri
BACKGROUND: Traditional risk factors for cardiovascular disease (CVD) have been thoroughly investigated. We aimed to investigate the impact of comorbid cardiovascular risk factors and diseases on length of stay (LOS) and mortality in patients presenting with acute coronary syndromes (ACS). METHODS: We examined prevalence of CVD, LOS and mortality from 25,287 consecutive admissions for ACS from seven hospitals across North West England between 2000 and 2013 using the ACALM (Algorithm for Comorbidities, Associations, Length of stay and Mortality) protocol using ICD-10 and OPCS-4 coding systems...
October 1, 2016: International Journal of Cardiology
Richard J Vargo, Anitha Potluri, Richard E Bauer, Raja R Seethala, Elizabeth A Bilodeau
This report and review of the literature describes a case of benign intraoral lesions of perineurial origin in a patient with symptomatic hemimandibular hyperplasia causing partial denture soreness. Perineuriomas are a benign peripheral nerve sheath tumor composed of perineurial cells. Intraoral perineuriomas are an extremely rare entity. Two main types of perineuriomas have been described: intraneural and extraneural perineuriomas. A third, similar entity, called an intraneural pseudoperineuriomatous proliferation, has recently been proposed in the literature as a separate and distinctive diagnosis...
December 2016: Head and Neck Pathology
Rosie M Hayes, Paul R Carter, Nicholas D Gollop, Hardeep Uppal, Jaydeep Sarma, Suresh Chandran, Rahul Potluri
No abstract text is available yet for this article.
June 1, 2016: International Journal of Cardiology
Vishnu S Potluri, Chirag R Parikh, Isaac E Hall, Joseph Ficek, Mona D Doshi, Isabel Butrymowicz, Francis L Weng, Bernd Schröppel, Heather Thiessen-Philbrook, Peter P Reese
BACKGROUND AND OBJECTIVES: Data reported to the Organ Procurement and Transplantation Network (OPTN) are used in kidney transplant research, policy development, and assessment of center quality, but the accuracy of early post-transplant outcome measures is unknown. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: The Deceased Donor Study (DDS) is a prospective cohort study at five transplant centers. Research coordinators manually abstracted data from electronic records for 557 adults who underwent deceased donor kidney transplantation between April of 2010 and November of 2013...
February 5, 2016: Clinical Journal of the American Society of Nephrology: CJASN
R Potluri, S Ranjan, R Khurana, A M Lele, V Prabhakar, H Bhandari
No abstract text is available yet for this article.
November 2015: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
R Potluri, A M Farr, I Hirji, C Davis, H Bhandari, A Oukessou
No abstract text is available yet for this article.
November 2015: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
N Kubitz, R Potluri, M Mehra
No abstract text is available yet for this article.
November 2015: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
Subrahmanya D Vallabhapurapu, Sunil K Noothi, Derek A Pullum, Charles H Lawrie, Rachel Pallapati, Veena Potluri, Christian Kuntzen, Sohaib Khan, David R Plas, Robert Z Orlowski, Marta Chesi, W Michael Kuehl, P Leif Bergsagel, Michael Karin, Sivakumar Vallabhapurapu
Although transcriptional activation by NF-κB is well appreciated, physiological importance of transcriptional repression by NF-κB in cancer has remained elusive. Here we show that an HDAC4-RelB-p52 complex maintains repressive chromatin around proapoptotic genes Bim and BMF and regulates multiple myeloma (MM) survival and growth. Disruption of RelB-HDAC4 complex by a HDAC4-mimetic polypeptide blocks MM growth. RelB-p52 also represses BMF translation by regulating miR-221 expression. While the NIK-dependent activation of RelB-p52 in MM has been reported, we show that regardless of the activation status of NIK and the oncogenic events that cause plasma cell malignancy, several genetically diverse MM cells including Bortezomib-resistant MM cells are addicted to RelB-p52 for survival...
October 12, 2015: Nature Communications
Peter P Reese, Ofole Mgbako, Adam Mussell, Vishnu Potluri, Zahra Yekta, Simona Levsky, Scarlett Bellamy, Chirag R Parikh, Justine Shults, Karen Glanz, Harold I Feldman, Kevin Volpp
OBJECTIVE: Among chronic hemodialysis patients, hyperphosphatemia is common and associated with mortality. Behavioral economics and complementary behavior-change theories may offer valuable approaches to achieving phosphorus (PO4) control. The aim was to determine feasibility of implementing financial incentives and structured coaching to improve PO4 in the hemodialysis setting. DESIGN AND METHODS: This pilot randomized controlled trial was conducted in 3 urban dialysis units for 10 weeks among 36 adults with elevated serum PO4 (median >5...
November 2015: Journal of Renal Nutrition
Robert M Havey, Jeremy Goodsitt, Saeed Khayatzadeh, Muturi Muriuki, Tejaswy Potluri, Leonard I Voronov, Laurie M Lomasney, Avinash G Patwardhan
STUDY DESIGN: Cadaveric study to accurately measure lumbar neuroforaminal area and height throughout the flexion-extension range of motion (ROM). OBJECTIVE: Create a new computed tomography (CT)-based specimen-specific model technique to provide insight on the effects of kinematics on lumbar neuroforamen morphology during flexion-extension ROM. SUMMARY OF BACKGROUND DATA: Nerve root compression is a key factor in symptomatic progression of degenerative disc disease because these changes directly affect neuroforaminal area...
July 15, 2015: Spine
Marina Sirota, Gonneke Willemsen, Purnima Sundar, Steven J Pitts, Shobha Potluri, Edi Prifti, Sean Kennedy, S Dusko Ehrlich, Jacoline Neuteboom, Cornelis Kluft, Karen E Malone, David R Cox, Eco J C de Geus, Dorret I Boomsma
Twin and family studies have established the contribution of genetic factors to variation in metabolic, hematologic and immunological parameters. The majority of these studies analyzed single or combined traits into pre-defined syndromes. In the present study, we explore an alternative multivariate approach in which a broad range of metabolic, hematologic, and immunological traits are analyzed simultaneously to determine the resemblance of monozygotic (MZ) twin pairs, twin-spouse pairs and unrelated, non-cohabiting individuals...
2015: PloS One
H Uppal, S Chandran, R Potluri
BACKGROUND: Down syndrome is a genetic condition that contributes to a significantly shorter life expectancy compared with the general population. We investigated the most common comorbidities in a population of acute hospital patients with Down syndrome and further explored what the most common risk factors for mortality are within this population. METHOD: From our database of one million patients admitted to National Health Service (NHS) Trusts in northern England, we identified 558 people who had Down syndrome...
September 2015: Journal of Intellectual Disability Research: JIDR
Pallavi Samatha Yalamanchili, Davanapelly Pavithra, Sushma Potluri, P R Arunima
Gingival recession can result in an unesthetic appearance, hypersensitivity, and root caries. The physiological well-being of the patient is a significant factor associated with the success of dental therapy. Esthetics is one of the main concerns of the patient if recession is present especially in anteriors. Hence, the treatment of choice for root coverage for the anterior teeth should address the biological as well as the patient's aesthetic demands. Numerous surgical procedures have been implicated for root coverage...
November 2014: Journal of International Oral Health: JIOH
Norman B Best, Thomas Hartwig, Joshua S Budka, Brandon J Bishop, Elliot Brown, Devi P V Potluri, Bruce R Cooper, Gnanasiri S Premachandra, Cliff T Johnston, Burkhard Schulz
Plant growth regulators, such as hormones and their respective biosynthesis inhibitors, are effective tools to elucidate the physiological function of phytohormones in plants. A problem of chemical treatments, however, is the potential for interaction of the active compound with the growth media substrate. We studied the interaction and efficacy of propiconazole, a potent and specific inhibitor of brassinosteroid biosynthesis, with common soilless greenhouse growth media for rice, sorghum, and maize. Many of the tested growth media interacted with propiconazole reducing its efficacy up to a hundred fold...
2014: PloS One
Nicole M Cordina, Chu K Liew, Phani R Potluri, Paul M Curmi, Piotr G Fajer, Timothy M Logan, Joel P Mackay, Louise J Brown
The interaction between myosin and actin in cardiac muscle, modulated by the calcium (Ca2+) sensor Troponin complex (Tn), is a complex process which is yet to be fully resolved at the molecular level. Our understanding of how the binding of Ca2+ triggers conformational changes within Tn that are subsequently propagated through the contractile apparatus to initiate muscle activation is hampered by a lack of an atomic structure for the Ca2+-free state of the cardiac isoform. We have used paramagnetic relaxation enhancement (PRE)-NMR to obtain a description of the Ca2+-free state of cardiac Tn by describing the movement of key regions of the troponin I (cTnI) subunit upon the release of Ca2+ from Troponin C (cTnC)...
2014: PloS One
Matthew K Christenson, Andrew J Trease, Lakshmi-Prasad Potluri, Andrew J Jezewski, Vincent M Davis, Lindsey A Knight, Alan S Kolok, Paul H Davis
The northern leopard frog Rana (Lithobates) pipiens is an important animal model, being used extensively in cancer, neurology, physiology, and biomechanical studies. R. pipiens is a native North American frog whose range extends from northern Canada to southwest United States, but over the past few decades its populations have declined significantly and is now considered uncommon in large portions of the United States and Canada. To aid in the study and conservation of R. pipiens, this paper describes the first R...
2014: Journal of Genomics
Mudassar Baig, Ahmad Farag, Jamal Sajid, Rahul Potluri, R Bruce Irwin, Hafiz Mohammed Idrees Khalid
AIM: To assess current practice of United Kingdom cardiologists with respect to patients with reported shellfish/iodine allergy, and in particular the use of iodinated contrast for elective coronary angiography. Moreover we have reviewed the current evidence-base and guidelines available in this area. METHODS: A questionnaire survey was send to 500 senior United Kingdom cardiologists (almost 50% cardiologists registered with British Cardiovascular Society) using email and first 100 responses used to analyze practise...
March 26, 2014: World Journal of Cardiology
Jason Flannick, Gudmar Thorleifsson, Nicola L Beer, Suzanne B R Jacobs, Niels Grarup, Noël P Burtt, Anubha Mahajan, Christian Fuchsberger, Gil Atzmon, Rafn Benediktsson, John Blangero, Don W Bowden, Ivan Brandslund, Julia Brosnan, Frank Burslem, John Chambers, Yoon Shin Cho, Cramer Christensen, Desirée A Douglas, Ravindranath Duggirala, Zachary Dymek, Yossi Farjoun, Timothy Fennell, Pierre Fontanillas, Tom Forsén, Stacey Gabriel, Benjamin Glaser, Daniel F Gudbjartsson, Craig Hanis, Torben Hansen, Astradur B Hreidarsson, Kristian Hveem, Erik Ingelsson, Bo Isomaa, Stefan Johansson, Torben Jørgensen, Marit Eika Jørgensen, Sekar Kathiresan, Augustine Kong, Jaspal Kooner, Jasmina Kravic, Markku Laakso, Jong-Young Lee, Lars Lind, Cecilia M Lindgren, Allan Linneberg, Gisli Masson, Thomas Meitinger, Karen L Mohlke, Anders Molven, Andrew P Morris, Shobha Potluri, Rainer Rauramaa, Rasmus Ribel-Madsen, Ann-Marie Richard, Tim Rolph, Veikko Salomaa, Ayellet V Segrè, Hanna Skärstrand, Valgerdur Steinthorsdottir, Heather M Stringham, Patrick Sulem, E Shyong Tai, Yik Ying Teo, Tanya Teslovich, Unnur Thorsteinsdottir, Jeff K Trimmer, Tiinamaija Tuomi, Jaakko Tuomilehto, Fariba Vaziri-Sani, Benjamin F Voight, James G Wilson, Michael Boehnke, Mark I McCarthy, Pål R Njølstad, Oluf Pedersen, Leif Groop, David R Cox, Kari Stefansson, David Altshuler
Loss-of-function mutations protective against human disease provide in vivo validation of therapeutic targets, but none have yet been described for type 2 diabetes (T2D). Through sequencing or genotyping of ~150,000 individuals across 5 ancestry groups, we identified 12 rare protein-truncating variants in SLC30A8, which encodes an islet zinc transporter (ZnT8) and harbors a common variant (p.Trp325Arg) associated with T2D risk and glucose and proinsulin levels. Collectively, carriers of protein-truncating variants had 65% reduced T2D risk (P = 1...
April 2014: Nature Genetics
Kai Ye, Marian Beekman, Eric-Wubbo Lameijer, Yanju Zhang, Matthijs H Moed, Erik B van den Akker, Joris Deelen, Jeanine J Houwing-Duistermaat, Dennis Kremer, Seyed Yahya Anvar, Jeroen F J Laros, David Jones, Keiran Raine, Ben Blackburne, Shobha Potluri, Quan Long, Victor Guryev, Ruud van der Breggen, Rudi G J Westendorp, Peter A C 't Hoen, Johan den Dunnen, Gert Jan B van Ommen, Gonneke Willemsen, Steven J Pitts, David R Cox, Zemin Ning, Dorret I Boomsma, P Eline Slagboom
It has been postulated that aging is the consequence of an accelerated accumulation of somatic DNA mutations and that subsequent errors in the primary structure of proteins ultimately reach levels sufficient to affect organismal functions. The technical limitations of detecting somatic changes and the lack of insight about the minimum level of erroneous proteins to cause an error catastrophe hampered any firm conclusions on these theories. In this study, we sequenced the whole genome of DNA in whole blood of two pairs of monozygotic (MZ) twins, 40 and 100 years old, by two independent next-generation sequencing (NGS) platforms (Illumina and Complete Genomics)...
December 2013: Twin Research and Human Genetics: the Official Journal of the International Society for Twin Studies
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