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https://www.readbyqxmd.com/read/28934075/gerontological-education-course-and-experiential-differences-across-academic-colleges
#1
Hardeep K Obhi, Jennifer A Margrett, Yan Su, Sarah L Francis, Young-A Lee, Denise A Crawford, Warren D Franke
A knowledgeable workforce is key to meeting the demands of an aging population that is expected to nearly triple by 2030 and attitudes influence propensity to seek aging-related careers. Post-secondary education offers an opportunity to increase aging-related knowledge and facilitates intergenerational experiential-learning opportunities; however, research is lacking regarding attitudes towards aging and experiences among an academically diverse sample. To address this gap, the aims of this study were to: (1) examine differences in students' attitudes toward older adults by academic college; (2) assess differences in aging-related coursework and course experiences by academic college; and (3) explore key factors associated with students' attitudes toward older adults...
September 21, 2017: Gerontology & Geriatrics Education
https://www.readbyqxmd.com/read/28933756/a-disposable-amperometric-sensor-based-on-high-performance-pedot-pss-ionic-liquid-nanocomposite-thin-film-modified-screen-printed-electrode-for-the-analysis-of-catechol-in-natural-water-samples
#2
Francis D Krampa, Yaw Aniweh, Gordon A Awandare, Prosper Kanyong
A conducting polymer-based composite material of poly(3,4-ethylenedioxythiophene) (PEDOT): poly(4-styrenesulfonate) (PSS) doped with different percentages of a room temperature ionic liquid (IL), 1-ethyl-3-methylimidazolium tetrafluoroborate ([EMIM][BF₄]), was prepared and a very small amount of the composite (2.0 µL) was drop-coated on the working area of a screen-printed carbon electrode (SPCE). The SPCE, modified with PEDOT:PSS/IL composite thin-film, was characterized by cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS), scanning electron microscopy (SEM), profilometry and sessile contact angle measurements...
July 26, 2017: Sensors
https://www.readbyqxmd.com/read/28931652/responsive-monitoring-of-mitochondrial-redox-states-in-heart-muscle-predicts-impending-cardiac-arrest
#3
Dorothy A Perry, Joshua W Salvin, Padraic Romfh, Peili Chen, Kalyani Krishnamurthy, Lindsay M Thomson, Brian D Polizzotti, Francis X McGowan, Daryoosh Vakhshoori, John N Kheir
Assessing the adequacy of oxygen delivery to tissues is vital, particularly in the fields of intensive care medicine and surgery. As oxygen delivery to a cell becomes deficient, changes in mitochondrial redox state precede changes in cellular function. We describe a technique for the continuous monitoring of the mitochondrial redox state on the epicardial surface using resonance Raman spectroscopy. We quantify the reduced fraction of specific electron transport chain cytochromes, a metric we name the resonance Raman reduced mitochondrial ratio (3RMR)...
September 20, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/28925968/recent-progress-in-the-development-of-diagnostic-tests-for-malaria
#4
REVIEW
Francis D Krampa, Yaw Aniweh, Gordon A Awandare, Prosper Kanyong
The impact of malaria on global health has continually prompted the need to develop effective diagnostic strategies. In malaria endemic regions, routine diagnosis is hampered by technical and infrastructural challenges to laboratories. These laboratories lack standard facilities, expertise or diagnostic supplies; thus, therapy is administered based on clinical or self-diagnosis. There is the need for accurate diagnosis of malaria due to the continuous increase in the cost of medication, and the emergence and spread of drug resistant strains...
September 19, 2017: Diagnostics
https://www.readbyqxmd.com/read/28914401/2017-hrs-ehra-ecas-aphrs-solaece-expert-consensus-statement-on-catheter-and-surgical-ablation-of-atrial-fibrillation-executive-summary
#5
Hugh Calkins, Gerhard Hindricks, Riccardo Cappato, Young-Hoon Kim, Eduardo B Saad, Luis Aguinaga, Joseph G Akar, Vinay Badhwar, Josep Brugada, John Camm, Peng-Sheng Chen, Shih-Ann Chen, Mina K Chung, Jens Cosedis Nielsen, Anne B Curtis, D Wyn Davies, John D Day, André d'Avila, N M S Natasja de Groot, Luigi Di Biase, Mattias Duytschaever, James R Edgerton, Kenneth A Ellenbogen, Patrick T Ellinor, Sabine Ernst, Guilherme Fenelon, Edward P Gerstenfeld, David E Haines, Michel Haissaguerre, Robert H Helm, Elaine Hylek, Warren M Jackman, Jose Jalife, Jonathan M Kalman, Josef Kautzner, Hans Kottkamp, Karl Heinz Kuck, Koichiro Kumagai, Richard Lee, Thorsten Lewalter, Bruce D Lindsay, Laurent Macle, Moussa Mansour, Francis E Marchlinski, Gregory F Michaud, Hiroshi Nakagawa, Andrea Natale, Stanley Nattel, Ken Okumura, Douglas Packer, Evgeny Pokushalov, Matthew R Reynolds, Prashanthan Sanders, Mauricio Scanavacca, Richard Schilling, Claudio Tondo, Hsuan-Ming Tsao, Atul Verma, David J Wilber, Teiichi Yamane
No abstract text is available yet for this article.
September 15, 2017: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
https://www.readbyqxmd.com/read/28911512/cardioprotective-effects-of-hsp72%C3%A2-administration-on-ischemia-reperfusion-injury
#6
Takashi Tanimoto, Missag H Parseghian, Takehiro Nakahara, Hideki Kawai, Navneet Narula, Dongbin Kim, Robert Nishimura, Richard H Weisbart, Grace Chan, Richard A Richieri, Nezam Haider, Farhan Chaudhry, Glenn T Reynolds, John Billimek, Francis G Blankenberg, Partho P Sengupta, Artiom D Petrov, Takashi Akasaka, H William Strauss, Jagat Narula
BACKGROUND: Although early reperfusion is the most desirable intervention after ischemic myocardial insult, it may add to damage through oxidative stress. OBJECTIVES: This study investigated the cardioprotective effects of a single intravenous dose of heat shock protein-72 (HSP72) coupled to a single-chain variable fragment (Fv) of monoclonal antibody 3E10 (3E10Fv) in a rabbit ischemia-reperfusion model. The Fv facilitates rapid transport of HSP72 into cells, even with intact membranes...
September 19, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28911092/concurrent-and-sequential-initiation-of-ovarian-function-suppression-with-chemotherapy-in-premenopausal-women-with-endocrine-responsive-early-breast-cancer-an-exploratory-analysis-of-text-and-soft
#7
M M Regan, B A Walley, P A Francis, G F Fleming, I Láng, H L Gómez, M Colleoni, C Tondini, G Pinotti, M Salim, S Spazzapan, V Parmar, T Ruhstaller, E A Abdi, R D Gelber, A S Coates, A Goldhirsch, O Pagani
Background: Recent breast cancer treatment guidelines recommend that higher-risk premenopausal patients should receive ovarian function suppression (OFS) as part of adjuvant endocrine therapy. If chemotherapy is also given, it is uncertain whether to select concurrent or sequential OFS initiation. Design and methods: We analyzed 1872 patients enrolled in the randomized phase III TEXT and SOFT trials who received adjuvant chemotherapy for hormone receptor-positive, HER2-negative breast cancer and upon randomization to an OFS-containing adjuvant endocrine therapy, initiated gonadotropin-releasing-hormone-agonist triptorelin...
September 1, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28906288/ibd-live-series-case-8-treatment-options-for-refractory-esophageal-crohn-s-disease-and-hidradenitis-suppurativa
#8
Heba Iskandar, Julia B Greer, Alyssa M Krasinskas, Andrew T Tinsley, Walter A Koltun, Corey A Siegel, L Campbell Levy, Hans H Herfarth, Francis A Farraye, David G Binion, Joel R Rosh, David J Keljo, Kim L Isaacs, Miguel D Regueiro
No abstract text is available yet for this article.
October 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28902876/postoperative-lead-migration-in-deep-brain-stimulation-surgery-incidence-risk-factors-and-clinical-impact
#9
Takashi Morishita, Justin D Hilliard, Michael S Okun, Dan Neal, Kelsey A Nestor, David Peace, Alden A Hozouri, Mark R Davidson, Francis J Bova, Justin M Sporrer, Genko Oyama, Kelly D Foote
INTRODUCTION: Deep brain stimulation (DBS) is an effective treatment for multiple movement disorders and shows substantial promise for the treatment of some neuropsychiatric and other disorders of brain neurocircuitry. Optimal neuroanatomical lead position is a critical determinant of clinical outcomes in DBS surgery. Lead migration, defined as an unintended post-operative displacement of the DBS lead, has been previously reported. Despite several reports, however, there have been no systematic investigations of this issue...
2017: PloS One
https://www.readbyqxmd.com/read/28893424/quantifying-the-influence-of-5-rna-modifications-on-rna-polymerase-i-activity
#10
Francis D Appling, Aaron L Lucius, David A Schneider
For ensemble and single-molecule analyses of transcription, the use of synthetic transcription elongation complexes has been a versatile and powerful tool. However, structural analyses demonstrate that short RNA substrates, often employed in these assays, would occupy space within the RNA polymerase. Most commercial RNA oligonucleotides do not carry a 5'-triphosphate as would be present on a natural, de novo synthesized RNA. To examine the effects of 5'-moities on transcription kinetics, we measured nucleotide addition and 3'-dinucleotide cleavage by eukaryotic RNA polymerase I using 5'-hydroxyl and 5'-triphosphate RNA substrates...
September 1, 2017: Biophysical Chemistry
https://www.readbyqxmd.com/read/28893030/implication-of-posture-analysing-software-to-evaluate-the-postural-changes-after-corrective-exercise-strategy-on-subjects-with-upper-body-dysfunction-a-randomized-controlled-trial
#11
Purushothaman Senthil, S Sudhakar, S Porcelvan, T G Tilak Francis, D Rathnamala, R Radhakrishnan
INTRODUCTION: The postural adaptation is very common now a days in school going children, office desk oriented job, computer users and frequent mobile users, and in all major industrial workers. Several studies have documented a high incidence of postural abnormalities in a given population; however, methods of postural measurement were poorly defined. The implication of postural pro software to analyse the postural imbalance of upper body dysfunction is very rare and literature studies says that the kinematic changes in particular segment will produce pain/discomfort and thereby lesser productivity of subjects...
July 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28890115/rifm-fragrance-ingredient-safety-assessment-benzenepropanol-a-%C3%A3-dimethyl-cas-registry-number-56836-93-2
#12
A M Api, D Belsito, D Botelho, D Browne, M Bruze, G A Burton, J Buschmann, M L Dagli, M Date, W Dekant, C Deodhar, M Francis, A D Fryer, K Joshi, S La Cava, A Lapczynski, D C Liebler, D O'Brien, R Parakhia, A Patel, T M Penning, G Ritacco, J Romine, D Salvito, T W Schultz, I G Sipes, Y Thakkar, E H Theophilus, A K Tiethof, Y Tokura, S Tsang, J Wahler
No abstract text is available yet for this article.
September 7, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28888521/impact-of-center-left-ventricular-assist%C3%A2-device-volume-on-outcomes%C3%A2-after%C3%A2-implantion-an-intermacs-analysis
#13
Jennifer A Cowger, John M Stulak, Palak Shah, Todd F Dardas, Francis D Pagani, Shannon M Dunlay, Simon Maltais, Keith D Aaronson, Ramesh Singh, Nahush A Mokadam, James K Kirklin, Christopher T Salerno
OBJECTIVES: This study examined patient outcomes after left ventricular assist device (LVAD) implantation across a range of center surgical volumes. BACKGROUND: In order for a center to qualify for reimbursement, Centers for Medicare and Medicaid Services (CMS) requires it to implant ≥10 LVADs or total artificial hearts over a 3-year period. The impact of center LVAD surgical volumes on patient outcomes has not been thoroughly scrutinized. METHODS: Center volumes were provided for 7,416 patients undergoing LVAD implantation who were enrolled in INTERMACS (Interagency Registry for Mechanically Assisted Circulatory Support)...
August 30, 2017: JACC. Heart Failure
https://www.readbyqxmd.com/read/28887091/rifm-fragrance-ingredient-safety-assessment-4-isopropyl-2-methoxy-1-methylbenzene-cas-registry-number-6379-73-3
#14
A M Api, D Belsito, D Botelho, D Browne, M Bruze, G A Burton, J Buschmann, M L Dagli, M Date, W Dekant, C Deodhar, M Francis, A D Fryer, K Joshi, S La Cava, A Lapczynski, D C Liebler, D O'Brien, R Parakhia, A Patel, T M Penning, G Ritacco, J Romine, D Salvito, T W Schultz, I G Sipes, Y Thakkar, E H Theophilus, A K Tiethof, Y Tokura, S Tsang, J Wahler
No abstract text is available yet for this article.
September 5, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28886041/lower-limb-arterial-calcification-llac-scores-in-patients-with-symptomatic-peripheral-arterial-disease-are-associated-with-increased-cardiac-mortality-and-morbidity
#15
Mohammed M Chowdhury, Gregory C Makris, Jason M Tarkin, Francis R Joshi, Paul D Hayes, James H F Rudd, Patrick A Coughlin
AIMS: The association of coronary arterial calcification with cardiovascular morbidity and mortality is well-recognized. Lower limb arterial calcification (LLAC) is common in PAD but its impact on subsequent health is poorly described. We aimed to determine the association between a LLAC score and subsequent cardiovascular events in patients with symptomatic peripheral arterial disease (PAD). METHODS: LLAC scoring, and the established Bollinger score, were derived from a database of unenhanced CT scans, from patients presenting with symptomatic PAD...
2017: PloS One
https://www.readbyqxmd.com/read/28883928/cpap-impact-a-protocol-for-a-randomised-trial-of-bubble-continuous-positive-airway-pressure-versus-standard-care-for-high-risk-children-with-severe-pneumonia-using-adaptive-design-methods
#16
Andrew G Smith, Michelle Eckerle, Tisungane Mvalo, Brian Weir, Francis Martinson, Alfred Chalira, Norman Lufesi, Innocent Mofolo, Mina Hosseinipour, Eric D McCollum
INTRODUCTION: Pneumonia is a leading cause of mortality among children in low-resource settings. Mortality is greatest among children with high-risk conditions including HIV infection or exposure, severe malnutrition and/or severe hypoxaemia. WHO treatment recommendations include low-flow oxygen for children with severe pneumonia. Bubble continuous positive airway pressure (bCPAP) is a non-invasive support modality that provides positive end-expiratory pressure and oxygen. bCPAP is effective in the treatment of neonates in low-resource settings; its efficacy is unknown for high-risk children with severe pneumonia in low-resource settings...
2017: BMJ Open Respiratory Research
https://www.readbyqxmd.com/read/28879656/variability-in-responses-observed-in-human-white-adipose-tissue-models
#17
Rosalyn D Abbott, Francis E Borowsky, Carlo A Alonzo, Adam Zieba, Irene Georgakoudi, David L Kaplan
Obesity is a risk factor for a myriad of diseases including diabetes, cardiovascular dysfunction, cirrhosis and cancer and there is a need for new systems to study how excess adipose tissue relates to the onset of disease processes. This study provides proof of concept patient-specific tissue models of human white adipose tissue to accommodate the variability in human samples. Our 3D tissue engineering approach established lipolytic responses and changes in insulin-stimulated glucose uptake from small volumes of human lipoaspirate, making this methodology useful for patient specific sample source assessments of treatment strategies, drug responses, disease mechanisms and other responses that vary between patients...
September 6, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28878313/atomic-scale-engineering-of-ferroelectric-ferromagnetic-interfaces-of-epitaxial-perovskite-films-for-functional-properties
#18
Simon Hausmann, Jingfan Ye, Toshihiro Aoki, Jian-Guo Zheng, Jochen Stahn, Francis Bern, Binda Chen, Carmine Autieri, Biplab Sanyal, Pablo D Esquinazi, Peter Böni, Amitesh Paul
Besides epitaxial mismatch that can be accommodated by lattice distortions and/or octahedral rotations, ferroelectric-ferromagnetic interfaces are affected by symmetry mismatch and subsequent magnetic ordering. Here, we have investigated La0.67 Sr0.33 MnO3 (LSMO) samples with varying underlying unit cells (uc) of BaTiO3 (BTO) layer on (001) and (110) oriented substrates in order to elucidate the role of symmetry mismatch. Lattice mismatch for 3 uc of BTO and symmetry mismatch for 10 uc of BTO, both associated with local MnO6 octahedral distortions of the (001) LSMO within the first few uc, are revealed by scanning transmission electron microscopy...
September 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28870742/the-effect-of-smoking-on-thirty-day-postoperative-complications-after-total-joint-arthroplasty-a-propensity-score-matched-analysis
#19
Shawn Sahota, Francis Lovecchio, Ryan E Harold, Matthew D Beal, David W Manning
BACKGROUND: Total joint arthroplasty (TJA) is a highly successful treatment, but is burdensome to the national healthcare budget. National quality initiatives seek to reduce costly complications. Smoking's role in perioperative complication after TJA is less well known. This study aims to identify smoking's independent contribution to the risk of short-term complication after TJA. METHODS: All patients undergoing primary TJA between 2011 and 2012 were selected from the American College of Surgeon's National Surgical Quality Improvement Program's database...
August 1, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28865933/a-positive-touch-c-tactile-afferent-targeted-skin-stimulation-carries-an-appetitive-motivational-value
#20
Ralph Pawling, Paula D Trotter, Francis P McGlone, Susannah C Walker
The rewarding sensation of touch in affiliative interactions is hypothesised to be underpinned by an unmyelinated system of nerve fibres called C-tactile afferents (CTs). CTs are velocity tuned, responding optimally to slow, gentle touch, typical of a caress. Here we used evaluative conditioning to examine whether CT activation carries a positive affective value. A set of neutral faces were paired with robotically delivered touch to the forearm. With half the faces touch was delivered at a CT optimal velocity of 3cm/s (CT touch) and with the other half at a faster, non-CT optimal velocity of 30cm/s (Control touch)...
September 1, 2017: Biological Psychology
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