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https://www.readbyqxmd.com/read/29134193/snowball-earth-climate-dynamics-and-cryogenian-geology-geobiology
#1
Paul F Hoffman, Dorian S Abbot, Yosef Ashkenazy, Douglas I Benn, Jochen J Brocks, Phoebe A Cohen, Grant M Cox, Jessica R Creveling, Yannick Donnadieu, Douglas H Erwin, Ian J Fairchild, David Ferreira, Jason C Goodman, Galen P Halverson, Malte F Jansen, Guillaume Le Hir, Gordon D Love, Francis A Macdonald, Adam C Maloof, Camille A Partin, Gilles Ramstein, Brian E J Rose, Catherine V Rose, Peter M Sadler, Eli Tziperman, Aiko Voigt, Stephen G Warren
Geological evidence indicates that grounded ice sheets reached sea level at all latitudes during two long-lived Cryogenian (58 and ≥5 My) glaciations. Combined uranium-lead and rhenium-osmium dating suggests that the older (Sturtian) glacial onset and both terminations were globally synchronous. Geochemical data imply that CO2 was 10(2) PAL (present atmospheric level) at the younger termination, consistent with a global ice cover. Sturtian glaciation followed breakup of a tropical supercontinent, and its onset coincided with the equatorial emplacement of a large igneous province...
November 2017: Science Advances
https://www.readbyqxmd.com/read/29132697/treatment-of-postsurgical-chylothorax
#2
Janani S Reisenauer, Carlos A Puig, Chris J Reisenauer, Mark S Allen, Emily Bendel, Stephen D Cassivi, Francis C Nichols, Rob K Shen, Dennis A Wigle, Shanda H Blackmon
BACKGROUND: Postoperative chylothorax can be managed by any or all of observation, parenteral nutrition, surgical duct ligation, pleurodesis, or thoracic duct embolization. The objective of this study was to determine the efficacy of standard therapies, such as surgical duct ligation and observation, compared with newer treatment methods (thoracic duct embolization). METHODS: A prospectively maintained database at a single institution was used to identify and review patients with postoperative chylothorax from 2008 to 2015...
November 11, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29128805/ursolic-acid-affords-antidepressant-like-effects-in-mice-through-the-activation-of-pka-pkc-camk-ii-and-mek1-2
#3
Ana B Ramos-Hryb, Mauricio P Cunha, Francis L Pazini, Vicente Lieberknecht, Rui D S Prediger, Manuella P Kaster, Ana Lúcia S Rodrigues
BACKGROUND: Ursolic acid has been shown to display antidepressant-like effects in mice through the modulation of monoaminergic systems. In this study, we sought to investigate the involvement of signaling pathways on the antidepressant-like effects of ursolic acid. METHODS: Mice were treated orally with ursolic acid (0.1mg/kg) and, 45min later they received the followings inhibitors by intracerebroventricular route: H-89 (PKA inhibitor, 1μg/mouse), KN-62 (CAMK-II inhibitor, 1μg/mouse), chelerythrine (PKC inhibitor, 1μg/mouse), U0126 (MEK1/2 inhibitor, 5μg/mouse), PD98059 (MEK1/2 inhibitor, 5μg/mouse), wortmannin (PI3K irreversible inhibitor, 0...
May 24, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/29128615/rifm-fragrance-ingredient-safety-assessment-ethyl-2-3-6-trimethylcyclohexyl-carbonate-cas-registry-number-93981-50-1
#4
A M Api, D Belsito, D Botelho, D Browne, M Bruze, G A Burton, J Buschmann, M L Dagli, M Date, W Dekant, C Deodhar, M Francis, A D Fryer, K Joshi, S La Cava, A Lapczynski, D C Liebler, D O'brien, R Parakhia, A Patel, T M Penning, G Ritacco, J Romine, D Salvito, T W Schultz, I G Sipes, Y Thakkar, E H Theophilus, A K Tiethof, Y Tokura, S Tsang, J Wahler
No abstract text is available yet for this article.
November 8, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29128612/rifm-fragrance-ingredient-safety-assessment-oxacyclohexadecane-2-13-dione-cas-registry-number-38223-29-9
#5
A M Api, D Belsito, D Botelho, D Browne, M Bruze, G A Burton, J Buschmann, M L Dagli, M Date, W Dekant, C Deodhar, M Francis, A D Fryer, K Joshi, S La Cava, A Lapczynski, D C Liebler, D O'Brien, R Parakhia, A Patel, T M Penning, G Ritacco, J Romine, D Salvito, T W Schultz, I G Sipes, Y Thakkar, E H Theophilus, A K Tiethof, Y Tokura, S Tsang, J Wahler
No abstract text is available yet for this article.
November 8, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29127327/publisher-correction-atomic-scale-engineering-of-ferroelectric-ferromagnetic-interfaces-of-epitaxial-perovskite-films-for-functional-properties
#6
Simon Hausmann, Jingfan Ye, Toshihiro Aoki, Jian-Guo Zheng, Jochen Stahn, Francis Bern, Binda Chen, Carmine Autieri, Biplab Sanyal, Pablo D Esquinazi, Peter Böni, Amitesh Paul
A correction to this article has been published and is linked from the HTML version of this paper. The error has been fixed in the paper.
November 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29127232/epidemiology-of-hypertension-in-northern-tanzania-a-community-based-mixed-methods-study
#7
Sophie W Galson, Catherine A Staton, Francis Karia, Kajiru Kilonzo, Joseph Lunyera, Uptal D Patel, Julian T Hertz, John W Stanifer
INTRODUCTION: Sub-Saharan Africa is particularly vulnerable to the growing global burden of hypertension, but epidemiological studies are limited and barriers to optimal management are poorly understood. Therefore, we undertook a community-based mixed-methods study in Tanzania to investigate the epidemiology of hypertension and barriers to care. METHODS: In Northern Tanzania, between December 2013 and June 2015, we conducted a mixed-methods study, including a cross-sectional household epidemiological survey and qualitative sessions of focus groups and in-depth interviews...
November 9, 2017: BMJ Open
https://www.readbyqxmd.com/read/29124418/the-effect-of-pre-transplant-pain-and-chronic-disease-self-efficacy-on-quality-of-life-domains-in-the-year-following-hematopoietic-stem-cell-transplantation
#8
Madeline L O'Sullivan, Rebecca A Shelby, Caroline S Dorfman, Sarah A Kelleher, Hannah M Fisher, Krista A Rowe Nichols, Francis J Keefe, Anthony D Sung, Tamara J Somers
PURPOSE: Pain is common for hematopoietic stem cell transplant (HSCT) patients and may be experienced pre-transplant, acutely post-transplant, and for months or years following transplant. HSCT patients with persistent pain may be at risk for poor quality of life following transplant; however, the impact of pre-transplant pain on quality of life post-transplant is not well understood. Self-efficacy for chronic disease management is associated with quality of life among cancer patients and may impact quality of life for HSCT patients...
November 9, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29123174/d-cateslytin-a-new-antimicrobial-peptide-with-therapeutic-potential
#9
Abdurraouf Zaet, Pauline Dartevelle, Fadoua Daouad, Claire Ehlinger, Fabienne Quilès, Grégory Francius, Christian Boehler, Camille Bergthold, Benoît Frisch, Gilles Prévost, Philippe Lavalle, Francis Schneider, Youssef Haïkel, Marie-Hélène Metz-Boutigue, Céline Marban
The rise of antimicrobial resistant microorganisms constitutes an increasingly serious threat to global public health. As a consequence, the efficacy of conventional antimicrobials is rapidly declining, threatening the ability of healthcare professionals to cure common infections. Over the last two decades host defense peptides have been identified as an attractive source of new antimicrobials. In the present study, we characterized the antibacterial and mechanistic properties of D-Cateslytin (D-Ctl), a new epipeptide derived from L-Cateslytin, where all L-amino acids were replaced by D-amino acids...
November 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29122858/genome-sequences-of-chancellor-mitti-and-wintermute-three-subcluster-k4-phages-isolated-using-mycobacterium-smegmatis-mc-2-155
#10
Nicholas P Edgington, Stephanie M Voshell, Vassie C Ware, Francis F Akoto, Alexa A Alhout, Gurvina J Atwal, John B Balyozian, Zachary A Cadieux, Brianna M Chop, Steven G Cresawn, Netta Cudkevich, Dylan Z Faltine-Gonzalez, Rebecca A Garlena, Blair J Gilmer, Lee H Graham, Matthew S Grapel, Maaz M Haleem, Deborah Jacobs-Sera, Margaret A Kenna, Maryam A Khan, Taylor N Klein, Jamie B Korenberg, Brooke P Lichak, Catherine M Mageeney, Lauren N McKinley, Kourtney R Mendello, Cameron M Myers, Alexander T Nguyen, Bryan A Pasqualucci, Welkin H Pope, Lauren M Pyfer, Wascar A Ramirez, Julia R Reisner, Daniel A Russell, Paulene A Sapao, Virginia C Saux, Inderjeet Singh, Ty H Stoner, Rachel H Swope, Matthew J Thoonkuzhy, Madeleine L Walters, Lauren A Vargas, Croldy A Veliz, Kevin D Zhang, Caitlin M Zuilkoski, Graham F Hatfull
Mycobacteriophages Chancellor, Mitti, and Wintermute infect Mycobacterium smegmatis mc(2)155 and are closely related to phages Cheetobro and Fionnbharth in subcluster K4. Genome sizes range from 57,697 bp to 58,046 bp. Phages are predicted to be temperate and to infect the pathogen Mycobacterium tuberculosis.
November 9, 2017: Genome Announcements
https://www.readbyqxmd.com/read/29121268/association-of-polygenic-score-for-schizophrenia-and-hla-antigen-and-inflammation-genes-with-response-to-lithium-in-bipolar-affective-disorder-a-genome-wide-association-study
#11
Azmeraw T Amare, Klaus Oliver Schubert, Liping Hou, Scott R Clark, Sergi Papiol, Urs Heilbronner, Franziska Degenhardt, Fasil Tekola-Ayele, Yi-Hsiang Hsu, Tatyana Shekhtman, Mazda Adli, Nirmala Akula, Kazufumi Akiyama, Raffaella Ardau, Bárbara Arias, Jean-Michel Aubry, Lena Backlund, Abesh Kumar Bhattacharjee, Frank Bellivier, Antonio Benabarre, Susanne Bengesser, Joanna M Biernacka, Armin Birner, Clara Brichant-Petitjean, Pablo Cervantes, Hsi-Chung Chen, Caterina Chillotti, Sven Cichon, Cristiana Cruceanu, Piotr M Czerski, Nina Dalkner, Alexandre Dayer, Maria Del Zompo, J Raymond DePaulo, Bruno Étain, Peter Falkai, Andreas J Forstner, Louise Frisen, Mark A Frye, Janice M Fullerton, Sébastien Gard, Julie S Garnham, Fernando S Goes, Maria Grigoroiu-Serbanescu, Paul Grof, Ryota Hashimoto, Joanna Hauser, Stefan Herms, Per Hoffmann, Andrea Hofmann, Stephane Jamain, Esther Jiménez, Jean-Pierre Kahn, Layla Kassem, Po-Hsiu Kuo, Tadafumi Kato, John Kelsoe, Sarah Kittel-Schneider, Sebastian Kliwicki, Barbara König, Ichiro Kusumi, Gonzalo Laje, Mikael Landén, Catharina Lavebratt, Marion Leboyer, Susan G Leckband, Alfonso Tortorella, Mirko Manchia, Lina Martinsson, Michael J McCarthy, Susan McElroy, Francesc Colom, Marina Mitjans, Francis M Mondimore, Palmiero Monteleone, Caroline M Nievergelt, Markus M Nöthen, Tomas Novák, Claire O'Donovan, Norio Ozaki, Urban Ösby, Andrea Pfennig, James B Potash, Andreas Reif, Eva Reininghaus, Guy A Rouleau, Janusz K Rybakowski, Martin Schalling, Peter R Schofield, Barbara W Schweizer, Giovanni Severino, Paul D Shilling, Katzutaka Shimoda, Christian Simhandl, Claire M Slaney, Alessio Squassina, Thomas Stamm, Pavla Stopkova, Mario Maj, Gustavo Turecki, Eduard Vieta, Julia Volkert, Stephanie Witt, Adam Wright, Peter P Zandi, Philip B Mitchell, Michael Bauer, Martin Alda, Marcella Rietschel, Francis J McMahon, Thomas G Schulze, Bernhard T Baune
Importance: Lithium is a first-line mood stabilizer for the treatment of bipolar affective disorder (BPAD). However, the efficacy of lithium varies widely, with a nonresponse rate of up to 30%. Biological response markers are lacking. Genetic factors are thought to mediate treatment response to lithium, and there is a previously reported genetic overlap between BPAD and schizophrenia (SCZ). Objectives: To test whether a polygenic score for SCZ is associated with treatment response to lithium in BPAD and to explore the potential molecular underpinnings of this association...
November 9, 2017: JAMA Psychiatry
https://www.readbyqxmd.com/read/29120186/constrained-vs-free-cholesterol-in-dppc-membranes-a-comparison-of-chain-ordering-ability-using-deuterium-nmr
#12
Mehran Shaghaghi, Amir Keyvanloo, Zhaohua Huang, Francis C Szoka, Jenifer L Thewalt
We report here the first exploration of the nature of the hydrophobic region of bilayer membranes formed from sterol modified phospholipids [Huang, Z.; Szoka, F. C., Sterol-Modified Phospholipids: Cholesterol and Phospholipid Chimeras with Improved Biomembrane Properties. J. Am. Chem. Soc. 2008, 130 (46), 15702-15712] & [Ding, J.; Starling, A. P.; East, J.M.; Lee, A. G., Binding Sites for Cholesterol on Ca(2+)-ATPase Studied by using a Cholesterol-containing Phospholipid. Biochemistry. 1994, 33(16), 4974-4979]...
November 9, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29118316/distinct-campylobacter-fetus-lineages-adapted-as-livestock-pathogens-and-human-pathobionts-in-the-intestinal-microbiota
#13
Gregorio Iraola, Samuel C Forster, Nitin Kumar, Philippe Lehours, Sadjia Bekal, Francisco J García-Peña, Fernando Paolicchi, Claudia Morsella, Helmut Hotzel, Po-Ren Hsueh, Ana Vidal, Simon Lévesque, Wataru Yamazaki, Claudia Balzan, Agueda Vargas, Alessandra Piccirillo, Bonnie Chaban, Janet E Hill, Laura Betancor, Luis Collado, Isabelle Truyers, Anne C Midwinter, Hatice T Dagi, Francis Mégraud, Lucía Calleros, Ruben Pérez, Hugo Naya, Trevor D Lawley
Campylobacter fetus is a venereal pathogen of cattle and sheep, and an opportunistic human pathogen. It is often assumed that C. fetus infection occurs in humans as a zoonosis through food chain transmission. Here we show that mammalian C. fetus consists of distinct evolutionary lineages, primarily associated with either human or bovine hosts. We use whole-genome phylogenetics on 182 strains from 17 countries to provide evidence that C. fetus may have originated in humans around 10,500 years ago and may have "jumped" into cattle during the livestock domestication period...
November 8, 2017: Nature Communications
https://www.readbyqxmd.com/read/29118002/prevalence-and-risk-factor-for-injury-in-sub-saharan-africa-a-multicountry-study
#14
Megan B Diamond, Shona Dalal, Clement Adebamowo, David Guwatudde, Carien Laurence, Ikeoluwapo O Ajayi, Francis Bajunirwe, Marina A Njelekela, Faraja Chiwanga, Hans-Olov Adami, Joan Nankya-Mutyoba, Robert Kalyesubula, Todd G Reid, David Hemenway, Michelle D Holmes
INTRODUCTION: Injury-related morbidity is a neglected health concern in many low-income and middle-income countries. Most injury data in Africa have been collected from hospital-based studies, and few studies have occurred across multiple countries. Using data from a novel cohort, we examined the prevalence and incidence of serious injuries and associated risk factors across five sites in sub-Saharan Africa (SSA). METHODS: A common baseline and follow-up survey was administered to participants...
November 8, 2017: Injury Prevention: Journal of the International Society for Child and Adolescent Injury Prevention
https://www.readbyqxmd.com/read/29117173/corrigendum-the-cold-induced-lipokine-12-13-dihome-promotes-fatty-acid-transport-into-brown-adipose-tissue
#15
Matthew D Lynes, Luiz O Leiria, Morten Lundh, Alexander Bartelt, Farnaz Shamsi, Tian Lian Huang, Hirokazu Takahashi, Michael F Hirshman, Christian Schlein, Alexandra Lee, Lisa A Baer, Francis J May, Fei Gao, Niven R Narain, Emily Y Chen, Michael A Kiebish, Aaron M Cypess, Matthias Blüher, Laurie J Goodyear, Gökhan S Hotamisligil, Kristin I Stanford, Yu-Hua Tseng
This corrects the article DOI: 10.1038/nm.4297.
November 7, 2017: Nature Medicine
https://www.readbyqxmd.com/read/29117042/impact-of-patient-distance-from-ventricular-assist-device-implanting-center-on-short-and-long-term-outcomes
#16
Ashwin K Ravichandran, Palak Shah, Ramesh Singh, Keith D Aaronson, Francis D Pagani, John Stulak, Shannon M Dunlay, Todd F Dardas, Nahush A Mokadam, Christopher T Salerno, Jennifer A Cowger
Highly specialized left ventricular assist device care is not readily available in many areas, potentially limiting access to therapy. This retrospective analysis examines the relationship of outcomes by patient distance from implanting left ventricular assist device center within the Mechanical Circulatory Support Research Network. Zip codes were used to calculate patient distance, with the primary outcome of interest being 3-year survival by distance from the surgical center. Secondary outcomes included 90-day survival and incident event rates for the following: gastrointestinal bleeding, infection, cerebral event, and pump thrombosis...
November 7, 2017: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/29116985/resources-used-to-teach-the-physical-exam-to-preclerkship-medical-students-results-of-a-national-survey
#17
Toshiko Uchida, Francis I Achike, Angela D Blood, Mary Boyle, Jeanne M Farnan, Deepthiman Gowda, Joanne Hojsak, Robin K Ovitsh, Yoon Soo Park, Ronald Silvestri
PURPOSE: To examine the resources utilized in teaching the physical exam to preclerkship students at U.S. medical schools. METHOD: The Directors of Clinical Skills Courses (DOCS) developed a 49-question survey addressing the resources and pedagogical methods employed in preclerkship physical exam curricula. The survey was sent to all 141 LCME-accredited medical schools in October 2015. Results were averaged across schools and data were weighted by class size. RESULTS: Results from 106 medical schools (75% response rate) identified a median of 59 hours devoted to teaching the physical exam...
November 7, 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/29116125/erratum-large-meta-analysis-of-genome-wide-association-studies-identifies-five-loci-for-lean-body-mass
#18
M Carola Zillikens, Serkalem Demissie, Yi-Hsiang Hsu, Laura M Yerges-Armstrong, Wen-Chi Chou, Lisette Stolk, Gregory Livshits, Linda Broer, Toby Johnson, Daniel L Koller, Zoltán Kutalik, Jian'an Luan, Ida Malkin, Janina S Ried, Albert V Smith, Gudmar Thorleifsson, Liesbeth Vandenput, Jing Hua Zhao, Weihua Zhang, Ali Aghdassi, Kristina Åkesson, Najaf Amin, Leslie J Baier, Inês Barroso, David A Bennett, Lars Bertram, Rainer Biffar, Murielle Bochud, Michael Boehnke, Ingrid B Borecki, Aron S Buchman, Liisa Byberg, Harry Campbell, Natalia Campos Obanda, Jane A Cauley, Peggy M Cawthon, Henna Cederberg, Zhao Chen, Nam H Cho, Hyung Jin Choi, Melina Claussnitzer, Francis Collins, Steven R Cummings, Philip L De Jager, Ilja Demuth, Rosalie A M Dhonukshe-Rutten, Luda Diatchenko, Gudny Eiriksdottir, Anke W Enneman, Mike Erdos, Johan G Eriksson, Joel Eriksson, Karol Estrada, Daniel S Evans, Mary F Feitosa, Mao Fu, Melissa Garcia, Christian Gieger, Thomas Girke, Nicole L Glazer, Harald Grallert, Jagvir Grewal, Bok-Ghee Han, Robert L Hanson, Caroline Hayward, Albert Hofman, Eric P Hoffman, Georg Homuth, Wen-Chi Hsueh, Monica J Hubal, Alan Hubbard, Kim M Huffman, Lise B Husted, Thomas Illig, Erik Ingelsson, Till Ittermann, John-Olov Jansson, Joanne M Jordan, Antti Jula, Magnus Karlsson, Kay-Tee Khaw, Tuomas O Kilpeläinen, Norman Klopp, Jacqueline S L Kloth, Heikki A Koistinen, William E Kraus, Stephen Kritchevsky, Teemu Kuulasmaa, Johanna Kuusisto, Markku Laakso, Jari Lahti, Thomas Lang, Bente L Langdahl, Lenore J Launer, Jong-Young Lee, Markus M Lerch, Joshua R Lewis, Lars Lind, Cecilia Lindgren, Yongmei Liu, Tian Liu, Youfang Liu, Östen Ljunggren, Mattias Lorentzon, Robert N Luben, William Maixner, Fiona E McGuigan, Carolina Medina-Gomez, Thomas Meitinger, Håkan Melhus, Dan Mellström, Simon Melov, Karl Michaëlsson, Braxton D Mitchell, Andrew P Morris, Leif Mosekilde, Anne Newman, Carrie M Nielson, Jeffrey R O'Connell, Ben A Oostra, Eric S Orwoll, Aarno Palotie, Stephen C J Parker, Munro Peacock, Markus Perola, Annette Peters, Ozren Polasek, Richard L Prince, Katri Räikkönen, Stuart H Ralston, Samuli Ripatti, John A Robbins, Jerome I Rotter, Igor Rudan, Veikko Salomaa, Suzanne Satterfield, Eric E Schadt, Sabine Schipf, Laura Scott, Joban Sehmi, Jian Shen, Chan Soo Shin, Gunnar Sigurdsson, Shad Smith, Nicole Soranzo, Alena Stančáková, Elisabeth Steinhagen-Thiessen, Elizabeth A Streeten, Unnur Styrkarsdottir, Karin M A Swart, Sian-Tsung Tan, Mark A Tarnopolsky, Patricia Thompson, Cynthia A Thomson, Unnur Thorsteinsdottir, Emmi Tikkanen, Gregory J Tranah, Jaakko Tuomilehto, Natasja M van Schoor, Arjun Verma, Peter Vollenweider, Henry Völzke, Jean Wactawski-Wende, Mark Walker, Michael N Weedon, Ryan Welch, H-Erich Wichmann, Elisabeth Widen, Frances M K Williams, James F Wilson, Nicole C Wright, Weijia Xie, Lei Yu, Yanhua Zhou, John C Chambers, Angela Döring, Cornelia M van Duijn, Michael J Econs, Vilmundur Gudnason, Jaspal S Kooner, Bruce M Psaty, Timothy D Spector, Kari Stefansson, Fernando Rivadeneira, André G Uitterlinden, Nicholas J Wareham, Vicky Ossowski, Dawn Waterworth, Ruth J F Loos, David Karasik, Tamara B Harris, Claes Ohlsson, Douglas P Kiel
A correction to this article has been published and is linked from the HTML version of this article.
November 7, 2017: Nature Communications
https://www.readbyqxmd.com/read/29109393/scalable-whole-exome-sequencing-of-cell-free-dna-reveals-high-concordance-with-metastatic-tumors
#19
Viktor A Adalsteinsson, Gavin Ha, Samuel S Freeman, Atish D Choudhury, Daniel G Stover, Heather A Parsons, Gregory Gydush, Sarah C Reed, Denisse Rotem, Justin Rhoades, Denis Loginov, Dimitri Livitz, Daniel Rosebrock, Ignaty Leshchiner, Jaegil Kim, Chip Stewart, Mara Rosenberg, Joshua M Francis, Cheng-Zhong Zhang, Ofir Cohen, Coyin Oh, Huiming Ding, Paz Polak, Max Lloyd, Sairah Mahmud, Karla Helvie, Margaret S Merrill, Rebecca A Santiago, Edward P O'Connor, Seong H Jeong, Rachel Leeson, Rachel M Barry, Joseph F Kramkowski, Zhenwei Zhang, Laura Polacek, Jens G Lohr, Molly Schleicher, Emily Lipscomb, Andrea Saltzman, Nelly M Oliver, Lori Marini, Adrienne G Waks, Lauren C Harshman, Sara M Tolaney, Eliezer M Van Allen, Eric P Winer, Nancy U Lin, Mari Nakabayashi, Mary-Ellen Taplin, Cory M Johannessen, Levi A Garraway, Todd R Golub, Jesse S Boehm, Nikhil Wagle, Gad Getz, J Christopher Love, Matthew Meyerson
Whole-exome sequencing of cell-free DNA (cfDNA) could enable comprehensive profiling of tumors from blood but the genome-wide concordance between cfDNA and tumor biopsies is uncertain. Here we report ichorCNA, software that quantifies tumor content in cfDNA from 0.1× coverage whole-genome sequencing data without prior knowledge of tumor mutations. We apply ichorCNA to 1439 blood samples from 520 patients with metastatic prostate or breast cancers. In the earliest tested sample for each patient, 34% of patients have ≥10% tumor-derived cfDNA, sufficient for standard coverage whole-exome sequencing...
November 6, 2017: Nature Communications
https://www.readbyqxmd.com/read/29109123/a-protective-function-of-il-22bp-in-ischemia-reperfusion-and-acetaminophen-induced-liver-injury
#20
Dörte Kleinschmidt, Anastasios D Giannou, Heather M McGee, Jan Kempski, Babett Steglich, Francis Jessica Huber, Thomas Michael Ernst, Ahmad Mustafa Shiri, Claudia Wegscheid, Elena Tasika, Peter Hübener, Philipp Huber, Tanja Bedke, Niklas Steffens, Theodora Agalioti, Tobias Fuchs, Jill Noll, Hannelore Lotter, Gisa Tiegs, Ansgar W Lohse, Jonathan H Axelrod, Eithan Galun, Richard A Flavell, Nicola Gagliani, Samuel Huber
Acute liver injury can be secondary to a variety of causes, including infections, intoxication, and ischemia. All of these insults induce hepatocyte death and subsequent inflammation, which can make acute liver injury a life-threatening event. IL-22 is a dual natured cytokine which has context-dependent protective and pathogenic properties during tissue damage. Accordingly, IL-22 was shown to promote liver regeneration upon acute liver damage. However, other studies suggest pathogenic properties of IL-22 during chronic liver injury...
November 6, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
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