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https://www.readbyqxmd.com/read/28812572/population-characteristics-of-a-large-whale-shark-aggregation-inferred-from-seawater-environmental-dna
#1
Eva Egelyng Sigsgaard, Ida Broman Nielsen, Steffen Sanvig Bach, Eline D Lorenzen, David Philip Robinson, Steen Wilhelm Knudsen, Mikkel Winther Pedersen, Mohammed Al Jaidah, Ludovic Orlando, Eske Willerslev, Peter Rask Møller, Philip Francis Thomsen
Population genetics is essential for understanding and managing marine ecosystems, but sampling remains challenging. We demonstrate that high-throughput sequencing of seawater environmental DNA can provide useful estimates of genetic diversity in a whale shark (Rhincodon typus) aggregation. We recover similar mitochondrial haplotype frequencies in seawater compared to tissue samples, reliably placing the studied aggregation in a global genetic context and expanding the applications of environmental DNA to encompass population genetics of aquatic organisms...
November 21, 2016: Nature ecology & evolution
https://www.readbyqxmd.com/read/28807480/opportunities-and-challenges-in-screening-for-childhood-sexual-abuse
#2
Deepa L Sekhar, Jennifer L Kraschnewski, Heather L Stuckey, Pamela D Witt, Erica B Francis, Ginger A Moore, Paul L Morgan, Jennie G Noll
Retrospective studies suggest 1 in 4 girls and 1 in 6 boys will experience sexual abuse before 18 years of age, resulting in future morbidity. Successful interventions exist, however, victims are reluctant to disclose. Screening for childhood sexual abuse (CSA) may provide an opportunity to overcome this barrier, yet no current model for universal CSA screening exists. We sought to understand the perspective of key stakeholders on CSA screening through qualitative research. Eight focus groups of 7-10 participants each (n=62) were conducted from April-September 2016...
August 11, 2017: Child Abuse & Neglect
https://www.readbyqxmd.com/read/28807427/paediatric-fracture-clinic-re-design-incorporating-a-virtual-fracture-clinic
#3
Paul M Robinson, Francis Sim, Mark Latimer, Piers D Mitchell
INTRODUCTION: The use of virtual fracture clinics (VFCs) and home management protocols is increasing. The main aim of this research is to determine whether a paediatric home management programme and VFC can be used safely to manage a range of suitable fractures in children. MATERIALS AND METHODS: Protocols for the home management of stable paediatric fractures were designed by two consultant paediatric orthopaedic surgeons. These were for children between the ages of 18 months and 15 years 364 days...
August 4, 2017: Injury
https://www.readbyqxmd.com/read/28802219/development-and-validation-of-a-high-performance-liquid-chromatography-tandem-mass-spectrometry-method-to-quantify-ly-354-740-in-rat-and-marmoset-plasma
#4
Fleur Gaudette, Adjia Hamadjida, Dominique Bédard, Stephen G Nuara, Francis Beaudry, Philippe Huot
LY-354,740 (eglumegad) is a selective and potent agonist of the metabotropic glutamate group II receptors (mGluR2,3) that has already entered clinical trials as a potential anti-psychotic agent and therefore has well-documented pharmacokinetic (PK), safety and tolerability profiles in human. Whereas its development as an anti-psychotic agent has not been pursued, LY-354,740 may have potential in other neuroscience-related fields, notably anxiety and neuro-protection. The common marmoset is a small primate that has long been used in neuroscience...
July 15, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28799444/the-msoac-approach-to-developing-performance-outcomes-to-measure-and-monitor-multiple-sclerosis-disability
#5
Nicholas G LaRocca, Lynn D Hudson, Richard Rudick, Dagmar Amtmann, Laura Balcer, Ralph Benedict, Robert Bermel, Ih Chang, Nancy D Chiaravalloti, Peter Chin, Jeffrey A Cohen, Gary R Cutter, Mat D Davis, John DeLuca, Peter Feys, Gordon Francis, Myla D Goldman, Emily Hartley, Raj Kapoor, Fred Lublin, Gary Lundstrom, Paul M Matthews, Nancy Mayo, Richard Meibach, Deborah M Miller, Robert W Motl, Ellen M Mowry, Rob Naismith, Jon Neville, Jennifer Panagoulias, Michael Panzara, Glenn Phillips, Ann Robbins, Matthew F Sidovar, Kathryn E Smith, Bjorn Sperling, Bernard Mj Uitdehaag, Jerry Weaver
BACKGROUND: The Multiple Sclerosis Outcome Assessments Consortium (MSOAC) was formed by the National MS Society to develop improved measures of multiple sclerosis (MS)-related disability. OBJECTIVES: (1) To assess the current literature and available data on functional performance outcome measures (PerfOs) and (2) to determine suitability of using PerfOs to quantify MS disability in MS clinical trials. METHODS: (1) Identify disability dimensions common in MS; (2) conduct a comprehensive literature review of measures for those dimensions; (3) develop an MS Clinical Data Interchange Standards Consortium (CDISC) data standard; (4) create a database of standardized, pooled clinical trial data; (5) analyze the pooled data to assess psychometric properties of candidate measures; and (6) work with regulatory agencies to use the measures as primary or secondary outcomes in MS clinical trials...
August 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/28799231/efficacy-of-daratumumab-based-therapies-in-patients-with-relapsed-refractory-multiple-myeloma-treated-outside-of-clinical-trials
#6
Arjun Lakshman, Jithma P Abeykoon, Shaji K Kumar, S Vincent Rajkumar, David Dingli, Francis K Buadi, Wilson I Gonsalves, Nelson Leung, Angela Dispenzieri, Taxiarchis V Kourelis, Ronald S Go, Martha Q Lacy, Miriam A Hobbs, Yi Lin, Rahma Warsame, John Lust, Amie L Fonder, Yi L Hwa, Suzanne R Hayman, Stephen J Russell, Robert A Kyle, Morie A Gertz, Prashant Kapoor
Outside of clinical trials, experience with daratumumab-based combination therapies (DCTs) using bortezomib (V)/lenalidomide (R)/pomalidomide (P), and dexamethasone (d) in relapsed/refractory multiple myeloma (RRMM) is limited. We reviewed the outcomes of 126 patients who received ≥ 1 cycle of any DCT. Median age at DCT initiation was 67 (range, 43-93) years. High-risk cytogenetics was present in 33% patients. Median number of prior therapies was 4 (range, 1-14) and time to first DCT from diagnosis was 4...
August 11, 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/28798137/cmr-native-t1-mapping-allows-differentiation-of-reversible-versus-irreversible-myocardial-damage-in-st-segment-elevation-myocardial-infarction-an-oxami-study-oxford-acute-myocardial-infarction
#7
Dan Liu, Alessandra Borlotti, Dafne Viliani, Michael Jerosch-Herold, Mohammad Alkhalil, Giovanni Luigi De Maria, Gregor Fahrni, Sam Dawkins, Rohan Wijesurendra, Jane Francis, Vanessa Ferreira, Stefan Piechnik, Matthew D Robson, Adrian Banning, Robin Choudhury, Stefan Neubauer, Keith Channon, Rajesh Kharbanda, Erica Dall'Armellina
BACKGROUND: CMR T1 mapping is a quantitative imaging technique allowing the assessment of myocardial injury early after ST-segment-elevation myocardial infarction. We sought to investigate the ability of acute native T1 mapping to differentiate reversible and irreversible myocardial injury and its predictive value for left ventricular remodeling. METHODS AND RESULTS: Sixty ST-segment-elevation myocardial infarction patients underwent acute and 6-month 3T CMR, including cine, T2-weighted (T2W) imaging, native shortened modified look-locker inversion recovery T1 mapping, rest first pass perfusion, and late gadolinium enhancement...
August 2017: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28796935/focal-irreversible-electroporation-as-primary-treatment-for-localized-prostate-cancer
#8
Willemien van den Bos, Matthijs J Scheltema, Amila R Siriwardana, Anton M F Kalsbeek, James E Thompson, Francis Ting, Maret Böhm, Anne-Maree Haynes, Ron Shnier, Warick Delprado, Phillip D Stricker
OBJECTIVES: To determine the safety, quality of life (QoL) and short-term oncological outcomes of primary focal IRE for the treatment of localized prostate cancer. To identify potential risk factors for oncological failure. PATIENTS AND METHODS: Patients that met both the consensus guidelines on patient criteria and selection methods for primary focal therapy were eligible for analysis. Focal IRE was performed for organ-confined clinically significant PCa, being high-volume Gleason sum score 6 (ISUP grade 1) or any Gleason sum score 7 (ISUP grade 2-3)...
August 10, 2017: BJU International
https://www.readbyqxmd.com/read/28792916/penetrating-injury-from-plastic-airsoft-pellet-shows-beam-hardening-artifact-on-computer-tomography
#9
Divakar Gupta, Tina D Tailor, Courtney Francis, Kalpana Kanal, Todd Klesert
PURPOSE: To describe a case of left eye corneal perforation, cataract, hyphema, and intraocular foreign body after airsoft pellet injury. METHODS: The authors reviewed the medical history and diagnostic imaging of a 12-year-old boy injured by a pellet from an airsoft gun. Typically, plastic airsoft pellets cause blunt trauma to the globe, which can lead to visual disability from corneal abrasion or hyphema. Initial computed tomography of the left orbit showed a 6...
December 19, 2016: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/28792416/identifying-coagulopathies-in-the-pathophysiology-of-cold-stress-syndrome-in-the-florida-manatee-trichechus-manatus-latirostris
#10
Ashley Barratclough, Bobbi J Conner, Marjory B Brooks, Alyssa Pontes Stablein, Trevor J Gerlach, Roger L Reep, Ray L Ball, Ruth Francis Floyd
Cold stress syndrome (CSS) in the Florida manatee Trichechus manatus latirostris has been defined as morbidity and mortality resulting from prolonged exposure to water temperatures <20°C. The pathophysiology is described as multifactorial, involving nutritional, immunological and metabolic disturbances; however, the exact mechanisms are unknown. We hypothesized that thromboembolic complications contribute to the pathophysiology of CSS in addition to the previously described factors. During the winter of 2014-2015, 10 Florida manatees with clinical signs of CSS were presented to Lowry Park Zoo, Tampa, FL, USA...
August 9, 2017: Diseases of Aquatic Organisms
https://www.readbyqxmd.com/read/28783021/acoustic-environments-matter-synergistic-benefits-to-humans-and-ecological-communities
#11
REVIEW
Clinton D Francis, Peter Newman, B Derrick Taff, Crow White, Christopher A Monz, Mitchell Levenhagen, Alissa R Petrelli, Lauren C Abbott, Jennifer Newton, Shan Burson, Caren B Cooper, Kurt M Fristrup, Christopher J W McClure, Daniel Mennitt, Michael Giamellaro, Jesse R Barber
Protected areas are critical locations worldwide for biodiversity preservation and offer important opportunities for increasingly urbanized humans to experience nature. However, biodiversity preservation and visitor access are often at odds and creative solutions are needed to safeguard protected area natural resources in the face of high visitor use. Managing human impacts to natural soundscapes could serve as a powerful tool for resolving these conflicting objectives. Here, we review emerging research that demonstrates that the acoustic environment is critical to wildlife and that sounds shape the quality of nature-based experiences for humans...
August 3, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28781171/first-line-selective-internal-radiotherapy-plus-chemotherapy-versus-chemotherapy-alone-in-patients-with-liver-metastases-from-colorectal-cancer-foxfire-sirflox-and-foxfire-global-a-combined-analysis-of-three-multicentre-randomised-phase-3-trials
#12
Harpreet S Wasan, Peter Gibbs, Navesh K Sharma, Julien Taieb, Volker Heinemann, Jens Ricke, Marc Peeters, Michael Findlay, Andrew Weaver, Jamie Mills, Charles Wilson, Richard Adams, Anne Francis, Joanna Moschandreas, Pradeep S Virdee, Peter Dutton, Sharon Love, Val Gebski, Alastair Gray, Guy van Hazel, Ricky A Sharma
BACKGROUND: Data suggest selective internal radiotherapy (SIRT) in third-line or subsequent therapy for metastatic colorectal cancer has clinical benefit in patients with colorectal liver metastases with liver-dominant disease after chemotherapy. The FOXFIRE, SIRFLOX, and FOXFIRE-Global randomised studies evaluated the efficacy of combining first-line chemotherapy with SIRT using yttrium-90 resin microspheres in patients with metastatic colorectal cancer with liver metastases. The studies were designed for combined analysis of overall survival...
August 3, 2017: Lancet Oncology
https://www.readbyqxmd.com/read/28777456/development-of-the-learning-health-system-researcher-core-competencies
#13
Christopher B Forrest, Francis D Chesley, Michelle L Tregear, Kamila B Mistry
OBJECTIVE: To develop core competencies for learning health system (LHS) researchers to guide the development of training programs. DATA SOURCES/STUDY SETTING: Data were obtained from literature review, expert interviews, a modified Delphi process, and consensus development meetings. STUDY DESIGN: The competencies were developed from August to December 2016 using qualitative methods. DATA COLLECTION/EXTRACTION METHODS: The literature review formed the basis for the initial draft of a competency domain framework...
August 4, 2017: Health Services Research
https://www.readbyqxmd.com/read/28772037/cardiac-and-peripheral-autonomic-control-in-restrictive-cardiomyopathy
#14
Ana Luiza C Sayegh, Marcelo R Dos Santos, Adriana O Sarmento, Francis R de Souza, Vera M C Salemi, Viviane T Hotta, Akothirene Cristhina D B Marques, Heidrum H Krämer, Ivani C Trombetta, Charles Mady, Maria Janieire de Nazaré Nunes Alves
AIMS: Autonomic dysfunction determines the advance of dilated cardiomyopathy (DCM) and is related to poor outcomes. However, this autonomic imbalance is unknown in patients with restrictive cardiomyopathy (RCM) even though they have similar symptoms and poor quality of life as DCM patients have. The aim of this study was to evaluate if autonomic and neurovascular controls were altered in RCM patients. METHODS AND RESULTS: Fifteen RCM patients, 10 DCM patients, and 10 healthy subjects were evaluated...
August 2017: ESC Heart Failure
https://www.readbyqxmd.com/read/28769880/human-gut-microbiota-toward-an-ecology-of-disease
#15
REVIEW
Susannah Selber-Hnatiw, Belise Rukundo, Masoumeh Ahmadi, Hayfa Akoubi, Hend Al-Bizri, Adelekan F Aliu, Tanyi U Ambeaghen, Lilit Avetisyan, Irmak Bahar, Alexandra Baird, Fatema Begum, Hélène Ben Soussan, Virginie Blondeau-Éthier, Roxane Bordaries, Helene Bramwell, Alicia Briggs, Richard Bui, Matthew Carnevale, Marisa Chancharoen, Talia Chevassus, Jin H Choi, Karyne Coulombe, Florence Couvrette, Samantha D'Abreau, Meghan Davies, Marie-Pier Desbiens, Tamara Di Maulo, Sean-Anthony Di Paolo, Sabrina Do Ponte, Priscyla Dos Santos Ribeiro, Laure-Anne Dubuc-Kanary, Paola K Duncan, Frédérique Dupuis, Sara El-Nounou, Christina N Eyangos, Natasha K Ferguson, Nancy R Flores-Chinchilla, Tanya Fotakis, Mariam Gado Oumarou H D, Metodi Georgiev, Seyedehnazanin Ghiassy, Natalija Glibetic, Julien Grégoire Bouchard, Tazkia Hassan, Iman Huseen, Marlon-Francis Ibuna Quilatan, Tania Iozzo, Safina Islam, Dilan B Jaunky, Aniththa Jeyasegaram, Marc-André Johnston, Matthew R Kahler, Kiranpreet Kaler, Cedric Kamani, Hessam Karimian Rad, Elisavet Konidis, Filip Konieczny, Sandra Kurianowicz, Philippe Lamothe, Karina Legros, Sebastien Leroux, Jun Li, Monica E Lozano Rodriguez, Sean Luponio-Yoffe, Yara Maalouf, Jessica Mantha, Melissa McCormick, Pamela Mondragon, Thivaedee Narayana, Elizaveta Neretin, Thi T T Nguyen, Ian Niu, Romeo B Nkemazem, Martin O'Donovan, Matthew Oueis, Stevens Paquette, Nehal Patel, Emily Pecsi, Jackie Peters, Annie Pettorelli, Cassandra Poirier, Victoria R Pompa, Harshvardhan Rajen, Reginald-Olivier Ralph, Josué Rosales-Vasquez, Daria Rubinshtein, Surya Sakr, Mohammad S Sebai, Lisa Serravalle, Fily Sidibe, Ahnjana Sinnathurai, Dominique Soho, Adithi Sundarakrishnan, Veronika Svistkova, Tsolaye E Ugbeye, Megan S Vasconcelos, Michael Vincelli, Olga Voitovich, Pamela Vrabel, Lu Wang, Maryse Wasfi, Cong Y Zha, Chiara Gamberi
Composed of trillions of individual microbes, the human gut microbiota has adapted to the uniquely diverse environments found in the human intestine. Quickly responding to the variances in the ingested food, the microbiota interacts with the host via reciprocal biochemical signaling to coordinate the exchange of nutrients and proper immune function. Host and microbiota function as a unit which guards its balance against invasion by potential pathogens and which undergoes natural selection. Disturbance of the microbiota composition, or dysbiosis, is often associated with human disease, indicating that, while there seems to be no unique optimal composition of the gut microbiota, a balanced community is crucial for human health...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28765636/high-resolution-patterned-cellular-constructs-by-droplet-based-3d-printing
#16
Alexander D Graham, Sam N Olof, Madeline J Burke, James P K Armstrong, Ellina A Mikhailova, James G Nicholson, Stuart J Box, Francis G Szele, Adam W Perriman, Hagan Bayley
Bioprinting is an emerging technique for the fabrication of living tissues that allows cells to be arranged in predetermined three-dimensional (3D) architectures. However, to date, there are limited examples of bioprinted constructs containing multiple cell types patterned at high-resolution. Here we present a low-cost process that employs 3D printing of aqueous droplets containing mammalian cells to produce robust, patterned constructs in oil, which were reproducibly transferred to culture medium. Human embryonic kidney (HEK) cells and ovine mesenchymal stem cells (oMSCs) were printed at tissue-relevant densities (10(7) cells mL(-1)) and a high droplet resolution of 1 nL...
August 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28762303/beyond-phonosurgery-considerations-for-patient-reported-outcomes-and-speech-therapy-in-transgender-vocal-feminization
#17
Shane D Morrison, Christopher S Crowe, Vania Rashidi, Jonathan P Massie, Scott R Chaiet, David O Francis
No abstract text is available yet for this article.
August 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28757440/nitric-oxide-synthase-inhibition-impairs-muscle-regrowth-following-immobilization
#18
Andreo Fernando Aguiar, Ivan José Vechetti-Júnior, Rodrigo Wagner Souza, Warlen Pereira Piedade, Francis Lopes Pacagnelli, André Soares Leopoldo, Juliano Casonatto, Maeli Dal-Pai-Silva
Nitric oxide (NO) has been shown to increase skeletal muscle protein synthesis. However, the role of NO during skeletal muscle regrowth after immobilization remains unknown. The purpose of this study was to determine whether NO is required for muscle regrowth/recovery after a period of disuse by immobilization. Male Wistar rats were divided into 4 groups: recovered, 1-(2-trifluoromethyl-phenyl)-imidazole (TRIM; 10 mg·kg body mass(-1)·day(-1)), N(G)-nitro-l-arginine methyl ester (l-NAME; 90 mg·kg body mass(-1)·day(-1)), and control...
July 28, 2017: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/28757150/temporal-differences-in-outcomes-during-long-term-mechanical-circulatory-support
#19
Simon Maltais, Lucman A Anwer, Nicholas A Haglund, Jennifer Cowger, Palak Shah, Keith D Aaronson, Francis D Pagani, Shannon M Dunlay, Ramesh Singh, Christopher T Salerno, John M Stulak
BACKGROUND: Device indications have changed for placement of continuous-flow left ventricular assist devices (CF-LVADs). We performed a multicenter analysis evaluating temporal variations in outcomes after CF-LVAD implantation. METHODS & RESULTS: We retrospectively defined three time intervals to reflect changes in CF-LVAD technology (Period 1: 2004 to 2009; Period 2: 2010 to 2012; and Period 3: 2012 to 2014). A total of 1,064 patients (HeartMate II (HMII)=835, HeartWare (HVAD)=229) underwent CF-LVAD implantation between May 2004 and October 2014...
July 27, 2017: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/28754780/2017-national-standards-for-diabetes-self-management-education-and-support
#20
Joni Beck, Deborah A Greenwood, Lori Blanton, Sandra T Bollinger, Marcene K Butcher, Jo Ellen Condon, Marjorie Cypress, Priscilla Faulkner, Amy Hess Fischl, Theresa Francis, Leslie E Kolb, Jodi M Lavin-Tompkins, Janice MacLeod, Melinda Maryniuk, Carolé Mensing, Eric A Orzeck, David D Pope, Jodi L Pulizzi, Ardis A Reed, Andrew S Rhinehart, Linda Siminerio, Jing Wang
No abstract text is available yet for this article.
July 28, 2017: Diabetes Care
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