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Sofat R

Christian R Jarry, Elizabeth F Martinez, Daiane C Peruzzo, Vanessa Carregaro, Laís A Sacramento, Vera C Araújo, M Neale Weitzmann, Marcelo H Napimoga
A novel T cell-secreted cytokine, termed secreted osteoclastogenic factor of activated T cells (SOFAT) that induces osteoclastic bone resorption in a RANKL-independent manner, has been described. Our group have previously reported that SOFAT is highly expressed in gingival tissues of patients with chronic periodontitis suggesting a putative role in the bone loss associated with periodontal disease. The aim of the present study was to identify other potential cellular sources of SOFAT in the bone resorptive lesions of patients with periodontal disease...
May 2016: Molecular Medicine Reports
Nicholas R Fuggle, Toby O Smith, Arvind Kaul, Nidhi Sofat
BACKGROUND: Rheumatoid arthritis (RA) and periodontitis are both chronic inflammatory diseases, which demonstrate similarities in terms of mechanism, histopathology, and demography. An association between these conditions has been demonstrated previously but has been called into question more recently. METHODS: The published databases, such as MEDLINE, EMBASE, and PsycINFO, were searched using search terms related to RA and periodontitis. Articles were selected if they included data on the number of people with RA diagnosed with periodontitis (or periodontal disease parameters) compared to a control comparison group...
2016: Frontiers in Immunology
Jon White, Reecha Sofat, Gibran Hemani, Tina Shah, Jorgen Engmann, Caroline Dale, Sonia Shah, Felix A Kruger, Claudia Giambartolomei, Daniel I Swerdlow, Tom Palmer, Stela McLachlan, Claudia Langenberg, Delilah Zabaneh, Ruth Lovering, Alana Cavadino, Barbara Jefferis, Chris Finan, Andrew Wong, Antoinette Amuzu, Ken Ong, Tom R Gaunt, Helen Warren, Teri-Louise Davies, Fotios Drenos, Jackie Cooper, Shah Ebrahim, Debbie A Lawlor, Philippa J Talmud, Steve E Humphries, Christine Power, Elina Hypponen, Marcus Richards, Rebecca Hardy, Diana Kuh, Nicholas Wareham, Yoav Ben-Shlomo, Ian N Day, Peter Whincup, Richard Morris, Mark W J Strachan, Jacqueline Price, Meena Kumari, Mika Kivimaki, Vincent Plagnol, John C Whittaker, George Davey Smith, Frank Dudbridge, Juan P Casas, Michael V Holmes, Aroon D Hingorani
BACKGROUND: Increased circulating plasma urate concentration is associated with an increased risk of coronary heart disease, but the extent of any causative effect of urate on risk of coronary heart disease is still unclear. In this study, we aimed to clarify any causal role of urate on coronary heart disease risk using Mendelian randomisation analysis. METHODS: We first did a fixed-effects meta-analysis of the observational association of plasma urate and risk of coronary heart disease...
April 2016: Lancet Diabetes & Endocrinology
H Thom, W Hollingworth, P A Bryden, J Sterne, P N Bodalia, P Davies, J A Lopez-Lopez, G N Okoli, D M Caldwell, S Dias, D Eaton, J Higgins, C Salisbury, J Savovic, R Sofat, A Stephens-Boal, A Hingorani, N J Welton
No abstract text is available yet for this article.
November 2015: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
P Bryden, N J Welton, H Thom, J Sterne, P Bodalia, P Davies, J López-López, G N Okoli, D M Caldwell, S Dias, D Eaton, J Higgins, C Salisbury, J Savovic, R Sofat, A Stephens-Boal, A Hingorani, W Hollingworth
No abstract text is available yet for this article.
November 2015: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
J A Lopez-Lopez, J Sterne, P N Bodalia, P A Bryden, P Davies, G N Okoli, H Thom, D M Caldwell, S Dias, D Eaton, J Higgins, W Hollingworth, C Salisbury, J Savovic, R Sofat, A Stephens-Boal, N J Welton, A Hingorani
No abstract text is available yet for this article.
November 2015: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
P Bryden, N J Welton, H Thom, J Sterne, P Bodalia, P Davies, J López-López, G N Okoli, D M Caldwell, S Dias, D Eaton, J Higgins, C Salisbury, J Savovic, R Sofat, A Stephens-Boal, A Hingorani, W Hollingworth
No abstract text is available yet for this article.
November 2015: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
Velu Nair, Hemant Madan, Sunil Sofat, Prosenjit Ganguli, M J Jacob, Rajat Datta, Prashant Bharadwaj, R S Sarkar, A J Pandit, Soniya Nityanand, Pravin K Goel, Naveen Garg, Sanjay Gambhir, Paul V George, Sunil Chandy, Vikram Mathews, Oomen K George, K K Talwar, Ajay Bahl, Neelam Marwah, Anish Bhatacharya, Balram Bhargava, Balram Airan, Sujata Mohanty, Chetan D Patel, Alka Sharma, Shinjini Bhatnagar, A Mondal, Jacob Jose, A Srivastava
BACKGROUND & OBJECTIVES: Acute myocardial infarction (AMI) is characterized by irreparable and irreversible loss of cardiac myocytes. Despite major advances in the management of AMI, a large number of patients are left with reduced left ventricular ejection fraction (LVEF), which is a major determinant of short and long term morbidity and mortality. A review of 33 randomized control trials has shown varying improvement in left ventricular (LV) function in patients receiving stem cells compared to standard medical therapy...
August 2015: Indian Journal of Medical Research
Eveline Nüesch, Caroline Dale, Tom M Palmer, Jon White, Brendan J Keating, Erik Pa van Iperen, Anuj Goel, Sandosh Padmanabhan, Folkert W Asselbergs, W M Verschuren, C Wijmenga, Y T Van der Schouw, N C Onland-Moret, Leslie A Lange, G K Hovingh, Suthesh Sivapalaratnam, Richard W Morris, Peter H Whincup, Goya S Wannamethe, Tom R Gaunt, Shah Ebrahim, Laura Steel, Nikhil Nair, Alexander P Reiner, Charles Kooperberg, James F Wilson, Jennifer L Bolton, Stela McLachlan, Jacqueline F Price, Mark Wj Strachan, Christine M Robertson, Marcus E Kleber, Graciela Delgado, Winfried März, Olle Melander, Anna F Dominiczak, Martin Farrall, Hugh Watkins, Maarten Leusink, Anke H Maitland-van der Zee, Mark Ch de Groot, Frank Dudbridge, Aroon Hingorani, Yoav Ben-Shlomo, Debbie A Lawlor, A Amuzu, M Caufield, A Cavadino, J Cooper, T L Davies, F Drenos, J Engmann, C Finan, C Giambartolomei, R Hardy, S E Humphries, E Hypponen, M Kivimaki, D Kuh, M Kumari, K Ong, V Plagnol, C Power, M Richards, S Shah, T Shah, R Sofat, P J Talmud, N Wareham, H Warren, J C Whittaker, A Wong, D Zabaneh, George Davey Smith, Jonathan C Wells, David A Leon, Michael V Holmes, Juan P Casas
BACKGROUND: We investigated causal effect of completed growth, measured by adult height, on coronary heart disease (CHD), stroke and cardiovascular traits, using instrumental variable (IV) Mendelian randomization meta-analysis. METHODS: We developed an allele score based on 69 single nucleotide polymorphisms (SNPs) associated with adult height, identified by the IBCCardioChip, and used it for IV analysis against cardiovascular risk factors and events in 21 studies and 60 028 participants...
May 15, 2015: International Journal of Epidemiology
D R J Owen, R MacAllister, R Sofat
Use of intravenous furosemide rather than oral administration in acute decompensated congestive cardiac failure is universally recommended in international guidelines. We argue that this recommendation is not supported by the existing evidence, and suggest that trials should be performed to determine whether larger doses of oral furosemide should be prescribed prior to an IV switch. This could reduce length of hospital admissions and allow for more patients to be managed in the primary care setting.
August 2015: Clinical Pharmacology and Therapeutics
Michael Sosin, Sujata Sofat, Daniel R Felbaum, Kenneth P Seastedt, Kevin M McGrail, Parag Bhanot
PURPOSE: The purpose of this study was to describe operative times, complication rates, and outcomes following laparoscopic placement of the peritoneal catheter in ventriculoperitoneal (VP) and lumboperitoneal (LP) shunt insertion. METHODS: A retrospective review was performed of those who underwent laparoscopic-assisted VP or LP shunt insertion from July 2007 to August 2011. RESULTS: The study included 53 consecutive patients (35 women and 18 men)...
June 2015: Surgical Laparoscopy, Endoscopy & Percutaneous Techniques
Ursalan A Khan, Amar Bhavsar, Hasan Asif, Konstantina Karabatsou, James R S Leggate, Ajit Sofat, Ian D Kamaly-Asl
OBJECT: Surgeries for CNS tumors are frequently performed by general neurosurgeons and by those who specialize in surgical neurooncology. Subspecialization in neurosurgical practice has become common and may improve patient morbidity and mortality rates. However, the potential benefits for patients of having their surgeries performed by surgical neurooncologists remain unclear. Recently, a shift in patient care to those who practice predominantly surgical neurooncology has been promoted...
February 2015: Journal of Neurosurgery
Nicholas R Fuggle, Franklyn A Howe, Rachel L Allen, Nidhi Sofat
Rheumatoid arthritis (RA) is considered to be, in many respects, an archetypal autoimmune disease that causes activation of pro-inflammatory pathways resulting in joint and systemic inflammation. RA remains a major clinical problem with the development of several new therapies targeted at cytokine inhibition in recent years. In RA, biologic therapies targeted at inhibition of tumor necrosis factor alpha (TNFα) have been shown to reduce joint inflammation, limit erosive change, reduce disability and improve quality of life...
2014: Frontiers in Neuroscience
Saqa Ahmed, Tejal Magan, Mario Vargas, Abiola Harrison, Nidhi Sofat
Rheumatoid arthritis (RA) is an inflammatory autoimmune condition typified by systemic inflammation targeted toward synovial joints. Inhibition of proinflammatory networks by disease-modifying antirheumatic drugs, eg, methotrexate and biologic therapies, including tumor necrosis factor-α inhibitors, often leads to suppression of disease activity observed at the clinical level. However, despite the era of widespread use of disease-modifying treatments, there remain significant groups of patients who continue to experience pain...
2014: Journal of Pain Research
Daniel I Swerdlow, David Preiss, Karoline B Kuchenbaecker, Michael V Holmes, Jorgen E L Engmann, Tina Shah, Reecha Sofat, Stefan Stender, Paul C D Johnson, Robert A Scott, Maarten Leusink, Niek Verweij, Stephen J Sharp, Yiran Guo, Claudia Giambartolomei, Christina Chung, Anne Peasey, Antoinette Amuzu, KaWah Li, Jutta Palmen, Philip Howard, Jackie A Cooper, Fotios Drenos, Yun R Li, Gordon Lowe, John Gallacher, Marlene C W Stewart, Ioanna Tzoulaki, Sarah G Buxbaum, Daphne L van der A, Nita G Forouhi, N Charlotte Onland-Moret, Yvonne T van der Schouw, Renate B Schnabel, Jaroslav A Hubacek, Ruzena Kubinova, Migle Baceviciene, Abdonas Tamosiunas, Andrzej Pajak, Roman Topor-Madry, Urszula Stepaniak, Sofia Malyutina, Damiano Baldassarre, Bengt Sennblad, Elena Tremoli, Ulf de Faire, Fabrizio Veglia, Ian Ford, J Wouter Jukema, Rudi G J Westendorp, Gert Jan de Borst, Pim A de Jong, Ale Algra, Wilko Spiering, Anke H Maitland-van der Zee, Olaf H Klungel, Anthonius de Boer, Pieter A Doevendans, Charles B Eaton, Jennifer G Robinson, David Duggan, John Kjekshus, John R Downs, Antonio M Gotto, Anthony C Keech, Roberto Marchioli, Gianni Tognoni, Peter S Sever, Neil R Poulter, David D Waters, Terje R Pedersen, Pierre Amarenco, Haruo Nakamura, John J V McMurray, James D Lewsey, Daniel I Chasman, Paul M Ridker, Aldo P Maggioni, Luigi Tavazzi, Kausik K Ray, Sreenivasa Rao Kondapally Seshasai, JoAnn E Manson, Jackie F Price, Peter H Whincup, Richard W Morris, Debbie A Lawlor, George Davey Smith, Yoav Ben-Shlomo, Pamela J Schreiner, Myriam Fornage, David S Siscovick, Mary Cushman, Meena Kumari, Nick J Wareham, W M Monique Verschuren, Susan Redline, Sanjay R Patel, John C Whittaker, Anders Hamsten, Joseph A Delaney, Caroline Dale, Tom R Gaunt, Andrew Wong, Diana Kuh, Rebecca Hardy, Sekar Kathiresan, Berta A Castillo, Pim van der Harst, Eric J Brunner, Anne Tybjaerg-Hansen, Michael G Marmot, Ronald M Krauss, Michael Tsai, Josef Coresh, Ronald C Hoogeveen, Bruce M Psaty, Leslie A Lange, Hakon Hakonarson, Frank Dudbridge, Steve E Humphries, Philippa J Talmud, Mika Kivimäki, Nicholas J Timpson, Claudia Langenberg, Folkert W Asselbergs, Mikhail Voevoda, Martin Bobak, Hynek Pikhart, James G Wilson, Alex P Reiner, Brendan J Keating, Aroon D Hingorani, Naveed Sattar
BACKGROUND: Statins increase the risk of new-onset type 2 diabetes mellitus. We aimed to assess whether this increase in risk is a consequence of inhibition of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), the intended drug target. METHODS: We used single nucleotide polymorphisms in the HMGCR gene, rs17238484 (for the main analysis) and rs12916 (for a subsidiary analysis) as proxies for HMGCR inhibition by statins. We examined associations of these variants with plasma lipid, glucose, and insulin concentrations; bodyweight; waist circumference; and prevalent and incident type 2 diabetes...
January 24, 2015: Lancet
Michael V Holmes, Folkert W Asselbergs, Tom M Palmer, Fotios Drenos, Matthew B Lanktree, Christopher P Nelson, Caroline E Dale, Sandosh Padmanabhan, Chris Finan, Daniel I Swerdlow, Vinicius Tragante, Erik P A van Iperen, Suthesh Sivapalaratnam, Sonia Shah, Clara C Elbers, Tina Shah, Jorgen Engmann, Claudia Giambartolomei, Jon White, Delilah Zabaneh, Reecha Sofat, Stela McLachlan, Pieter A Doevendans, Anthony J Balmforth, Alistair S Hall, Kari E North, Berta Almoguera, Ron C Hoogeveen, Mary Cushman, Myriam Fornage, Sanjay R Patel, Susan Redline, David S Siscovick, Michael Y Tsai, Konrad J Karczewski, Marten H Hofker, W Monique Verschuren, Michiel L Bots, Yvonne T van der Schouw, Olle Melander, Anna F Dominiczak, Richard Morris, Yoav Ben-Shlomo, Jackie Price, Meena Kumari, Jens Baumert, Annette Peters, Barbara Thorand, Wolfgang Koenig, Tom R Gaunt, Steve E Humphries, Robert Clarke, Hugh Watkins, Martin Farrall, James G Wilson, Stephen S Rich, Paul I W de Bakker, Leslie A Lange, George Davey Smith, Alex P Reiner, Philippa J Talmud, Mika Kivimäki, Debbie A Lawlor, Frank Dudbridge, Nilesh J Samani, Brendan J Keating, Aroon D Hingorani, Juan P Casas
AIMS: To investigate the causal role of high-density lipoprotein cholesterol (HDL-C) and triglycerides in coronary heart disease (CHD) using multiple instrumental variables for Mendelian randomization. METHODS AND RESULTS: We developed weighted allele scores based on single nucleotide polymorphisms (SNPs) with established associations with HDL-C, triglycerides, and low-density lipoprotein cholesterol (LDL-C). For each trait, we constructed two scores. The first was unrestricted, including all independent SNPs associated with the lipid trait identified from a prior meta-analysis (threshold P < 2 × 10(-6)); and the second a restricted score, filtered to remove any SNPs also associated with either of the other two lipid traits at P ≤ 0...
March 1, 2015: European Heart Journal
Nidhi Sofat, Cori Smee, Monika Hermansson, Matthew Howard, Emma H Baker, Franklyn A Howe, Thomas R Barrick
BACKGROUND: Hand osteoarthritis (HOA) is typified by pain and reduced function. We hypothesised that people with HOA have enhanced sensitivity and activation of peripheral nociceptors in the hand, thereby potentiating chronic pain. In our study we aimed to assess if central sensitisation mediates pain perception in osteoarthritis of the hand. METHODS: Participants with proximal and distal interphalangeal joint (PIP/DIP) HOA and non-OA controls were recruited. Clinical pain scores using the visual analogue scale (VAS) were recorded before and after performing a painful hand task...
November 2013: Journal of Biomedical Graphics and Computing
Tina Shah, Delilah Zabaneh, Tom Gaunt, Daniel I Swerdlow, Sonia Shah, Philippa J Talmud, Ian N Day, John Whittaker, Michael V Holmes, Reecha Sofat, Steve E Humphries, Mika Kivimaki, Meena Kumari, Aroon D Hingorani, Juan P Casas
BACKGROUND- Inflammatory cytokine interleukin-6 (IL-6), a possible risk factor for coronary heart disease, has an estimated heritability of >60%, but to date few genetic variants influencing IL-6 levels are known. METHODS AND RESULTS- We used the ITMAT-Broad-Care (IBC) HumanCVD disease BeadChip in the Whitehall II study (N=4911) and British Women's Heart and Health Study (N=3445) to identify single-nucleotide polymorphisms associated with circulating IL-6 levels. Twenty-two single-nucleotide polymorphisms from 7 loci (IL6R/TDRD10, HLA-DRB1, BUD13, SEZ6L, IL1RN, TRIB3, and ABO) were associated with IL-6 (P<10(-5)), although none were associated with the IL6 gene itself...
April 2013: Circulation. Cardiovascular Genetics
Reecha Sofat, P Patrizia Mangione, J Ruth Gallimore, Svetlana Hakobyan, Timothy R Hughes, Tina Shah, Tim Goodship, Francesco D'Aiuto, Claudia Langenberg, Nick Wareham, B Paul Morgan, Mark B Pepys, Aroon D Hingorani
BACKGROUND: Research on complement factor H (fH) in human disease is hampered by lack of an assay suitable for use in large-scale epidemiological studies. We describe the development and validation of a high throughput nephelometric assay for fH. METHODS: Reagents from a commercial radial immunodiffusion (RID) assay (The Binding Site) were adapted for use on the Siemens BNII high throughput nephelometric instrument. The assay was calibrated with a highly purified human fH preparation with rigorously determined concentration, and assay performance was comprehensively evaluated using samples from healthy human volunteers, with the commercial RID assay as a comparator...
April 30, 2013: Journal of Immunological Methods
Usha Chakravarthy, Gareth J McKay, Paulus T V M de Jong, Mati Rahu, Johan Seland, Gisele Soubrane, Laura Tomazzoli, Fotis Topouzis, Johannes R Vingerling, Jesus Vioque, Ian S Young, Reecha Sofat, Aroon D Hingorani, Astrid E Fletcher
OBJECTIVE: To study associations between severity stages of early and late age-related macular degeneration (AMD) and genetic variations in age-related maculopathy susceptibility 2 (ARMS2) and complement factor H (CFH) and to investigate potential interactions between smoking and ARMS2. DESIGN: Population-based, cross-sectional European Eye Study in 7 countries in Europe. PARTICIPANTS: Four thousand seven hundred fifty participants, 65 years of age and older, recruited through random sampling...
February 2013: Ophthalmology
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