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https://www.readbyqxmd.com/read/27922026/percutaneous-gastrostomy-device-for-the-treatment-of-class-ii-and-class-iii-obesity-results-of-a-randomized-controlled-trial
#1
Christopher C Thompson, Barham K Abu Dayyeh, Robert Kushner, Shelby Sullivan, Alan B Schorr, Anastassia Amaro, Caroline M Apovian, Terrence Fullum, Amir Zarrinpar, Michael D Jensen, Adam C Stein, Steven Edmundowicz, Michel Kahaleh, Marvin Ryou, J Matthew Bohning, Gregory Ginsberg, Christopher Huang, Daniel D Tran, Joseph P Glaser, John A Martin, David L Jaffe, Francis A Farraye, Samuel B Ho, Nitin Kumar, Donna Harakal, Meredith Young, Catherine E Thomas, Alpana P Shukla, Michele B Ryan, Miki Haas, Heidi Goldsmith, Jennifer McCrea, Louis J Aronne
OBJECTIVES: The AspireAssist System (AspireAssist) is an endoscopic weight loss device that is comprised of an endoscopically placed percutaneous gastrostomy tube and an external device to facilitate drainage of about 30% of the calories consumed in a meal, in conjunction with lifestyle (diet and exercise) counseling. METHODS: In this 52-week clinical trial, 207 participants with a body-mass index (BMI) of 35.0-55.0 kg/m(2) were randomly assigned in a 2:1 ratio to treatment with AspireAssist plus Lifestyle Counseling (n=137; mean BMI was 42...
December 6, 2016: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/27892606/svep1-plays-a-crucial-role-in-epidermal-differentiation
#2
L Samuelov, Q Li, R Bochner, N Najor, L Albrecht, N Malchin, T Goldsmith, M Grafi-Cohen, D Vodo, G Fainberg, B Meilik, I Goldberg, E Warshauer, T Rogers, S Edie, A Ishida-Yamamoto, L Burzenski, N Erez, S A Murray, A D Irvine, L Shultz, K Green, J Uitto, E Sprecher, O Sarig
SVEP1 is a recently identified multi-domain cell adhesion protein, homologous to the mouse polydom protein, which has been shown to mediate cell-cell adhesion in an integrin dependent-manner in osteogenic cells. In the present study, we characterized SVEP1 function in the epidermis. SVEP1 was found by qRT-PCR to be ubiquitously expressed in human tissues, including the skin. Confocal microscopy revealed that SVEP1 is normally mostly expressed in the cytoplasm of basal and suprabasal epidermal cells. Down-regulation of SVEP1 expression in primary keratinocytes resulted in decreased expression of major epidermal differentiation markers...
November 28, 2016: Experimental Dermatology
https://www.readbyqxmd.com/read/27829478/demographic-and-lifestyle-factors-associated-with-adherence-to-the-mediterranean-diet-in-relation-to-overweight-obesity-among-israeli-adolescents-findings-from-the-mabat-israeli-national-youth-health-and-nutrition-survey
#3
Wen Peng, Rebecca Goldsmith, Elliot M Berry
OBJECTIVE: To investigate demographic and lifestyle factors associated with adherence to the Mediterranean diet (MD) in Israeli adolescents. DESIGN: Cross-sectional. SETTING: School-based. SUBJECTS: Schoolchildren (n 5268) aged 11-19 years answered self-administered questionnaires on food consumption, eating habits and lifestyle; a subset (n 578) also completed 24 h food recalls. RESULTS: Using a modified KIDMED index, 25·5 % of the students had poor, 55·2 % had average and 19·3 % had good MD adherence...
November 10, 2016: Public Health Nutrition
https://www.readbyqxmd.com/read/27816494/fragmentation-in-the-biopharmaceutical-industry
#4
REVIEW
Andrew D Goldsmith, Francisco Varela
The large number of biopharmaceutical mergers and acquisitions (M&A) that occurred over the past decade has generated questions about whether the industry is consolidating around too-few players, negatively impacting both the number of medicines developed and overall innovation. However, closer examination of the level of biopharmaceutical consolidation shows that the industry was more fragmented in 2015 than it was in 2003 by prescription drug sales. The trend towards increasing fragmentation is also observed across noncommercial and independent metrics over the same time period...
November 2, 2016: Drug Discovery Today
https://www.readbyqxmd.com/read/27810132/breast-cancer-recurrence-following-radioguided-seed-localization-and-standard-wire-localization-of-nonpalpable-invasive-and-in-situ-breast-cancers-5-year-follow-up-from-a-randomized-controlled-trial
#5
Filgen Fung, Sylvie D Cornacchi, Michael Reedijk, Nicole Hodgson, Charlie H Goldsmith, David McCready, Gabriela Gohla, Colm Boylan, Peter J Lovrics
BACKGROUND: This study compared 5-year breast cancer (BC) recurrence rates in patients randomized to radioguided seed localization (RSL) or wire localization (WL) for non-palpable BC undergoing breast conserving surgery. METHODS: Chart review of follow-up visits and surveillance imaging was conducted. Data collected included patient and tumour factors, adjuvant therapies and BC recurrence (local recurrence (LR), regional recurrence (RR), and distant metastasis (DM))...
October 20, 2016: American Journal of Surgery
https://www.readbyqxmd.com/read/27693323/interleukin-1%C3%AE-mediates-intestinal-inflammation-in-mice-and-patients-with-interleukin-10-receptor-deficiency
#6
Dror S Shouval, Amlan Biswas, Yu Hui Kang, Alexandra E Griffith, Liza Konnikova, Ivan D Mascanfroni, Naresh S Redhu, Sandra M Frei, Michael Field, Andria L Doty, Jeffrey D Goldsmith, Atul K Bhan, Anthony Loizides, Batia Weiss, Baruch Yerushalmi, Tadahiro Yanagi, Xiuli Lui, Francisco J Quintana, Aleixo M Muise, Christoph Klein, Bruce H Horwitz, Sarah C Glover, Athos Bousvaros, Scott B Snapper
Interleukin 10 receptor (IL10R)-deficient mice develop spontaneous colitis and, similarly, patients with loss-of-function mutations in IL10R develop severe infant-onset inflammatory bowel disease. Loss of IL10R signaling in mouse and human macrophages is associated with increased production of interleukin 1β. We demonstrated that innate immune production of IL1β mediates colitis in IL10R-deficient mice. Transfer of Il1r1(-/-) CD4(+) T cells into Rag1(-/-)/Il10rb(-/-) mice reduced the severity of their colitis (compared to mice that received CD4(+) T cells that express IL1R), accompanied by decreased production of interferon gamma, tumor necrosis factor-α, and IL17A...
December 2016: Gastroenterology
https://www.readbyqxmd.com/read/27647810/measurement-error-time-lag-unmeasured-confounding-considerations-for-longitudinal-estimation-of-the-effect-of-a-mediator-in-randomised-clinical-trials
#7
K A Goldsmith, T Chalder, P D White, M Sharpe, A Pickles
Clinical trials are expensive and time-consuming and so should also be used to study how treatments work, allowing for the evaluation of theoretical treatment models and refinement and improvement of treatments. These treatment processes can be studied using mediation analysis. Randomised treatment makes some of the assumptions of mediation models plausible, but the mediator-outcome relationship could remain subject to bias. In addition, mediation is assumed to be a temporally ordered longitudinal process, but estimation in most mediation studies to date has been cross-sectional and unable to explore this assumption...
September 19, 2016: Statistical Methods in Medical Research
https://www.readbyqxmd.com/read/27638476/rickettsia-amblyommatis-sp-nov-a-spotted-fever-group-rickettsia-associated-with-multiple-species-of-amblyomma-ticks-in-north-and-south-america
#8
Sandor E Karpathy, Kimetha S Slater, Cynthia S Goldsmith, William L Nicholson, Christopher D Paddock
In 1973, investigators isolated a rickettsial organism, designated strain WB-8-2T, from an adult Amblyomma americanum tick collected at Land Between the Lakes National Recreation Area, Tennessee. This organism is now recognized as highly prevalent in Amblyomma americanum, as well as several other Amblyomma species found throughout the Western Hemisphere, and it has been suggested that cross-reactivity to WB-8-2 T and similar strains contributes to the increasing number of spotted fever cases reported in the United States...
September 14, 2016: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/27637440/the-effect-of-prehospital-intubation-on-treatment-times-in-patients-with-suspected-traumatic-brain-injury
#9
Joshua D Lansom, Kate Curtis, Helen Goldsmith, Alex Tzannes
OBJECTIVE: This study examines whether, in patients requiring intubation with moderate to severe traumatic brain injury (TBI), prehospital intubation compared with emergency department intubation leads to a reduction in treatment times and time to a computed tomographic (CT) scan. METHODS: A retrospective cohort study compared adult patients with a Glasgow Coma Score of less than 14 with a suspected TBI who underwent intubation, either prehospital or on arrival to the emergency department...
September 2016: Air Medical Journal
https://www.readbyqxmd.com/read/27587113/a-compact-neutron-scatter-camera-for-field-deployment
#10
John E M Goldsmith, Mark D Gerling, James S Brennan
We describe a very compact (0.9 m high, 0.4 m diameter, 40 kg) battery operable neutron scatter camera designed for field deployment. Unlike most other systems, the configuration of the sixteen liquid-scintillator detection cells are arranged to provide omnidirectional (4π) imaging with sensitivity comparable to a conventional two-plane system. Although designed primarily to operate as a neutron scatter camera for localizing energetic neutron sources, it also functions as a Compton camera for localizing gamma sources...
August 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27541852/probing-heterogeneity-and-bonding-at-silica-surfaces-through-single-molecule-investigation-of-base-mediated-linkage-failure
#11
Katherine M Lupo, Daniel A Hinton, James D Ng, Nicolas A Padilla, Randall H Goldsmith
The nature of silica surfaces is relevant to many chemical systems, including heterogeneous catalysis and chromatographies utilizing functionalized-silica stationary phases. Surface linkages must be robust to achieve wide and reliable applicability. However, silyl ether-silica support linkages are known to be susceptible to detachment when exposed to basic conditions. We use single-molecule spectroscopy to examine the rate of surface linkage failure upon exposure to base at a variety of deposition conditions...
September 13, 2016: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/27522922/multifaceted-biological-insights-from-a-draft-genome-sequence-of-the-tobacco-hornworm-moth-manduca-sexta
#12
Michael R Kanost, Estela L Arrese, Xiaolong Cao, Yun-Ru Chen, Sanjay Chellapilla, Marian R Goldsmith, Ewald Grosse-Wilde, David G Heckel, Nicolae Herndon, Haobo Jiang, Alexie Papanicolaou, Jiaxin Qu, Jose L Soulages, Heiko Vogel, James Walters, Robert M Waterhouse, Seung-Joon Ahn, Francisca C Almeida, Chunju An, Peshtewani Aqrawi, Anne Bretschneider, William B Bryant, Sascha Bucks, Hsu Chao, Germain Chevignon, Jayne M Christen, David F Clarke, Neal T Dittmer, Laura C F Ferguson, Spyridoula Garavelou, Karl H J Gordon, Ramesh T Gunaratna, Yi Han, Frank Hauser, Yan He, Hanna Heidel-Fischer, Ariana Hirsh, Yingxia Hu, Hongbo Jiang, Divya Kalra, Christian Klinner, Christopher König, Christie Kovar, Ashley R Kroll, Suyog S Kuwar, Sandy L Lee, Rüdiger Lehman, Kai Li, Zhaofei Li, Hanquan Liang, Shanna Lovelace, Zhiqiang Lu, Jennifer H Mansfield, Kyle J McCulloch, Tittu Mathew, Brian Morton, Donna M Muzny, David Neunemann, Fiona Ongeri, Yannick Pauchet, Ling-Ling Pu, Ioannis Pyrousis, Xiang-Jun Rao, Amanda Redding, Charles Roesel, Alejandro Sanchez-Gracia, Sarah Schaack, Aditi Shukla, Guillaume Tetreau, Yang Wang, Guang-Hua Xiong, Walther Traut, Tom K Walsh, Kim C Worley, Di Wu, Wenbi Wu, Yuan-Qing Wu, Xiufeng Zhang, Zhen Zou, Hannah Zucker, Adriana D Briscoe, Thorsten Burmester, Rollie J Clem, René Feyereisen, Cornelis J P Grimmelikhuijzen, Stavros J Hamodrakas, Bill S Hansson, Elisabeth Huguet, Lars S Jermiin, Que Lan, Herman K Lehman, Marce Lorenzen, Hans Merzendorfer, Ioannis Michalopoulos, David B Morton, Subbaratnam Muthukrishnan, John G Oakeshott, Will Palmer, Yoonseong Park, A Lorena Passarelli, Julio Rozas, Lawrence M Schwartz, Wendy Smith, Agnes Southgate, Andreas Vilcinskas, Richard Vogt, Ping Wang, John Werren, Xiao-Qiang Yu, Jing-Jiang Zhou, Susan J Brown, Steven E Scherer, Stephen Richards, Gary W Blissard
Manduca sexta, known as the tobacco hornworm or Carolina sphinx moth, is a lepidopteran insect that is used extensively as a model system for research in insect biochemistry, physiology, neurobiology, development, and immunity. One important benefit of this species as an experimental model is its extremely large size, reaching more than 10 g in the larval stage. M. sexta larvae feed on solanaceous plants and thus must tolerate a substantial challenge from plant allelochemicals, including nicotine. We report the sequence and annotation of the M...
September 2016: Insect Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/27459958/quality-control-in-public-participation-assessments-of-water-quality-the-opal-water-survey
#13
N L Rose, S D Turner, B Goldsmith, L Gosling, T A Davidson
BACKGROUND: Public participation in scientific data collection is a rapidly expanding field. In water quality surveys, the involvement of the public, usually as trained volunteers, generally includes the identification of aquatic invertebrates to a broad taxonomic level. However, quality assurance is often not addressed and remains a key concern for the acceptance of publicly-generated water quality data. The Open Air Laboratories (OPAL) Water Survey, launched in May 2010, aimed to encourage interest and participation in water science by developing a 'low-barrier-to-entry' water quality survey...
2016: BMC Ecology
https://www.readbyqxmd.com/read/27411751/cognitive-behaviour-therapy-for-chronic-fatigue-syndrome-differences-in-treatment-outcome-between-a-tertiary-treatment-centre-in-the-united-kingdom-and-the-netherlands
#14
M Worm-Smeitink, S Nikolaus, K Goldsmith, J Wiborg, S Ali, H Knoop, T Chalder
OBJECTIVE: Cognitive behaviour therapy (CBT) reduces fatigue and disability in chronic fatigue syndrome (CFS). However, outcomes vary between studies, possibly because of differences in patient characteristics, treatment protocols, diagnostic criteria and outcome measures. The objective was to compare outcomes after CBT in tertiary treatment centres in the Netherlands (NL) and the United Kingdom (UK), using different treatment protocols but identical outcome measures, while controlling for differences in patient characteristics and diagnostic criteria...
August 2016: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/27326258/liver-label-retaining-cancer-cells-are-relatively-resistant-to-the-reported-anti-cancer-stem-cell-drug-metformin
#15
Hong-Wu Xin, Chenwi M Ambe, Tyler C Miller, Jin-Qiu Chen, Gordon W Wiegand, Andrew J Anderson, Satyajit Ray, John E Mullinax, Danielle M Hari, Tomotake Koizumi, Jessica D Godbout, Paul K Goldsmith, Alexander Stojadinovic, Udo Rudloff, Snorri S Thorgeirsson, Itzhak Avital
BACKGROUND & AIMS: Recently, we reported that liver Label Retaining Cancer Cells (LRCC) can initiate tumors with only 10 cells and are relatively resistant to the targeted drug Sorafenib, a standard of practice in advanced hepatocellular carcinoma (HCC). LRCC are the only cancer stem cells (CSC) isolated alive according to a stem cell fundamental function, asymmetric cell division. Metformin has been reported to preferentially target many other types of CSC of different organs, including liver...
2016: Journal of Cancer
https://www.readbyqxmd.com/read/27278080/calibrating-the-impact-of-dual-raas-blockade-on-the-heart-and-the-kidney-balancing-risks-and-benefits
#16
REVIEW
O J Ziff, A Covic, D Goldsmith
Overactivity of the renin-angiotensin-aldosterone system (RAAS) plays a key role in the pathophysiology of heart failure (HF) and chronic kidney disease (CKD). RAAS antagonists can significantly improve clinical outcomes, but monotherapy blocks but one step of the RAAS and can be bypassed through compensatory mechanisms. Providing more complete RAAS blockade by deploying drugs with complementary actions seemed logical - hence the practice of using dual (or triple) RAAS inhibitors. However, RAAS antagonists also exhibit dose-limiting side effects, including acute kidney injury, hyperkalaemia and hypotension, which blunt their overall effectiveness...
July 2016: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/27226206/ebola-virus-disease-in-pregnancy-clinical-histopathologic-and-immunohistochemical-findings
#17
Atis Muehlenbachs, Olimpia de la Rosa Vázquez, Daniel G Bausch, Ilana J Schafer, Christopher D Paddock, Jean Paul Nyakio, Papys Lame, Eric Bergeron, Andrea M McCollum, Cynthia S Goldsmith, Brigid C Bollweg, Miriam Alía Prieto, Robert Shongo Lushima, Benoit Kebela Ilunga, Stuart T Nichol, Wun-Ju Shieh, Ute Ströher, Pierre E Rollin, Sherif R Zaki
Here we describe clinicopathologic features of Ebola virus disease in pregnancy. One woman infected with Sudan virus in Gulu, Uganda, in 2000 had a stillbirth and survived, and another woman infected with Bundibugyo virus had a live birth with maternal and infant death in Isiro, the Democratic Republic of the Congo in 2012. Ebolavirus antigen was seen in the syncytiotrophoblast and placental maternal mononuclear cells by immunohistochemical analysis, and no antigen was seen in fetal placental stromal cells or fetal organs...
May 25, 2016: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/27214327/abstracts
#18
(no author information available yet)
The progression of HCV-associated liver disease in a cohort of haemophilic patients. Telfer P, Sabin C, Devereux H, Scott F, Dusheiko G, Lee C. Increasing hepatitis C virus RNA levels in hemophiliacs: relationship to human immunodeficiency virus infection and liver disease. Eyster E, Fried MW, Di Bisceglie AM, Goedert JJ. Risks of immunodeficiency, AIDS, and death related to purity of factor VIII concentrate. Goedert JJ, Cohen AR, Kessler CM, Eichinger S, Seremtis SV, Rabkin CS, Yellin FJ, Rosenberg PS, Aledort LM...
April 1995: Haemophilia: the Official Journal of the World Federation of Hemophilia
https://www.readbyqxmd.com/read/27214111/comparison-of-the-quality-of-life-between-hiv-positive-haemophilia-patients-and-hiv-negative-haemophilia-patients
#19
B Djulbegovic, G Goldsmith, D Vaughn, J Birkimer, M Marasa, G Joseph, A Huang, T Hadley
In a prospective study, we tested the hypothesis that an already reduced quality of life in haemophilia patients is further diminished in those haemophilia patients who contracted the human immunodeficiency virus (HIV) as a result of transfusion of coagulation factor preparations. From an available pool of 92 males with haemophilia A or B, 18 patients seropositive for HIV infection and 11 seronegative patients were randomly selected for the study. We applied two instruments to measure the quality of life (QOL) in our patients...
July 1996: Haemophilia: the Official Journal of the World Federation of Hemophilia
https://www.readbyqxmd.com/read/27190390/pro-should-we-correct-vitamin-d-deficiency-insufficiency-in-chronic-kidney-disease-patients-with-inactive-forms-of-vitamin-d-or-just-treat-them-with-active-vitamin-d-forms
#20
David J A Goldsmith
Evidence for the usefulness of using vitamin D to treat 'renal bone disease' is now nearly six decades old. In regular clinical practice, however, it is more like three decades, at most, that we have routinely been using vitamin D to try to prevent, or reverse, the impact of hyperparathyroidism on the skeleton of patients with chronic kidney disease (CKD). The practice has been in the main to use high doses of synthetic vitamin D compounds, not naturally occurring ones. However, the pharmacological impacts of the different vitamin D species and of their different modes, and styles of administration cannot be assumed to be uniform across the spectrum...
May 2016: Nephrology, Dialysis, Transplantation
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