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https://www.readbyqxmd.com/read/28805524/response-to-the-editorial-by-dr-geraghty
#1
Peter D White, Trudie Chalder, Michael Sharpe, Brian J Angus, Hannah L Baber, Jessica Bavinton, Mary Burgess, Lucy V Clark, Diane L Cox, Julia C DeCesare, Kimberley A Goldsmith, Anthony L Johnson, Paul McCrone, Gabrielle Murphy, Maurice Murphy, Hazel O'Dowd, Laura Potts, Rebacca Walwyn, David Wilks
This article is written in response to the linked editorial by Dr Geraghty about the adaptive Pacing, graded Activity and Cognitive behaviour therapy; a randomised Evaluation (PACE) trial, which we led, implemented and published. The PACE trial compared four treatments for people diagnosed with chronic fatigue syndrome. All participants in the trial received specialist medical care. The trial found that adding cognitive behaviour therapy or graded exercise therapy to specialist medical care was as safe as, and more effective than, adding adaptive pacing therapy or specialist medical care alone...
August 2017: Journal of Health Psychology
https://www.readbyqxmd.com/read/28753125/reaction-times-can-reflect-habits-rather-than-computations
#2
Aaron L Wong, Jeff Goldsmith, Alexander D Forrence, Adrian M Haith, John W Krakauer
Reaction times (RTs) are assumed to reflect the underlying computations required for making decisions and preparing actions. However, recent work has shown that movements can be initiated earlier than typically expressed without affecting performance; hence, the RT may be modulated by factors other than computation time. Consistent with that view, we demonstrated that RTs are influenced by prior experience: when a previously performed task required a specific RT to support task success, this biased the RTs in future tasks...
July 28, 2017: ELife
https://www.readbyqxmd.com/read/28699575/proposal-to-reclassify-ehrlichia-muris-as-ehrlichia-muris-subsp-muris-subsp-nov-and-description-of-ehrlichia-muris-subsp-eauclairensis-subsp-nov-a-newly-recognized-tick-borne-pathogen-of-humans
#3
Bobbi S Pritt, Michelle E J Allerdice, Lynne M Sloan, Christopher D Paddock, Ulrike G Munderloh, Yasuko Rikihisa, Tomoko Tajima, Susan M Paskewitz, David F Neitzel, Diep K Hoang Johnson, Elizabeth Schiffman, Jeffrey P Davis, Cynthia S Goldsmith, Curtis M Nelson, Sandor E Karpathy
We have previously described a novel taxon of the genus Ehrlichia (type strain WisconsinT), closely related to Ehrlichia muris, that causes human ehrlichiosis among patients with exposures to ticks in the upper midwestern USA. DNA from this bacterium was also detected in Ixodes scapularis and Peromyscus leucopus collected in Minnesota and Wisconsin. To determine the relationship between the E. muris-like agent (EMLA) and other species of the genus Ehrlichia phenotypic, genotypic and epidemiologic comparisons were undertaken, including sequence analysis of eight gene loci (3906 nucleotides) for 39 EMLA DNA samples and the type strain of E...
July 12, 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/28692190/dupuytren-s-contracture-and-handwork-a-case-control-study
#4
Alfred Haines, Carolyn Levis, Charles H Goldsmith, Manraj Kaur, Eric Duku, Richard Wells, Stephen D Walter, Cheryl Rook, Susan Stock, Gary Liss, Jessica Murphy, Achilleas Thoma
OBJECTIVE: The objective of this study was to examine the association between Dupuytren's contracture (DC), repetitive handwork (RHW), heavy handwork (HHW), and/or vibration exposure. METHODS: Frequency and intensity of the three types of handwork were collected and compared between DC patients and controls. Hours of work were weighted by average "frequency," for RHW, and average "intensity," for HHW and use of vibrating tool. Logistic regression was used to evaluate risk of developing DC associated with the above-mentioned factors...
August 2017: American Journal of Industrial Medicine
https://www.readbyqxmd.com/read/28665229/the-importance-of-epitope-density-in-selecting-a-sensitive-positive-ihc-control
#5
Kodela Vani, Seshi R Sompuram, Anika K Schaedle, Anuradha Balasubramanian, Monika Pilichowska, Stephen Naber, Jeffrey D Goldsmith, Kueikwun G Chang, Farzad Noubary, Steven A Bogen
Clinical Immunohistochemistry (IHC) laboratories face unique challenges in performing accurate and reproducible immunostains. Among these challenges is the use of homemade controls derived from pathological discard samples. Such positive controls have an unknown number of analyte molecules per cell (epitope density). It is unclear how the lack of defined analyte concentrations affects performance of the control. To address this question, we prepared positive IHC controls ( IHControls) for human epidermal growth factor receptor type II (HER-2), estrogen receptor (ER), or progesterone receptor (PR) with well-defined, homogeneous, and reproducible analyte concentrations...
August 2017: Journal of Histochemistry and Cytochemistry: Official Journal of the Histochemistry Society
https://www.readbyqxmd.com/read/28651526/study-protocol-for-a-randomised-pragmatic-trial-comparing-the-clinical-and-cost-effectiveness-of-lithium-and-quetiapine-augmentation-in-treatment-resistant-depression-the-lqd-study
#6
L Marwood, R Taylor, K Goldsmith, R Romeo, R Holland, A Pickles, J Hutchinson, D Dietch, A Cipriani, R Nair, M-J Attenburrow, A H Young, J Geddes, R H McAllister-Williams, A J Cleare
BACKGROUND: Approximately 30-50% of patients with major depressive disorder can be classed as treatment resistant, widely defined as a failure to respond to two or more adequate trials of antidepressants in the current episode. Treatment resistant depression is associated with a poorer prognosis and higher mortality rates. One treatment option is to augment an existing antidepressant with a second agent. Lithium and the atypical antipsychotic quetiapine are two such add-on therapies and are currently recommended as first line options for treatment resistant depression...
June 26, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28649413/identification-of-donor-microbe-species-that-colonize-and-persist-long-term-in-the-recipient-after-fecal-transplant-for-recurrent-clostridium-difficile
#7
Ranjit Kumar, Nengjun Yi, Degui Zhi, Peter Eipers, Kelly T Goldsmith, Paula Dixon, David K Crossman, Michael R Crowley, Elliot J Lefkowitz, J Martin Rodriguez, Casey D Morrow
Fecal microbiota transplantation has been shown to be an effective treatment for patients with recurrent C. difficile colitis. Although fecal microbiota transplantation helps to re-establish a normal gut function in patients, the extent of the repopulation of the recipient microbial community varies. To further understand this variation, it is important to determine the fate of donor microbes in the patients following fecal microbiota transplantation. We have developed a new method that utilizes the unique single nucleotide variants of gut microbes to accurately identify microbes in paired fecal samples from the same individual taken at different times...
2017: NPJ Biofilms and Microbiomes
https://www.readbyqxmd.com/read/28627118/optical-microresonators-for-sensing-and-transduction-a-materials-perspective
#8
REVIEW
Kevin D Heylman, Kassandra A Knapper, Erik H Horak, Morgan T Rea, Sudheer K Vanga, Randall H Goldsmith
Optical microresonators confine light to a particular microscale trajectory, are exquisitely sensitive to their microenvironment, and offer convenient readout of their optical properties. Taken together, this is an immensely attractive combination that makes optical microresonators highly effective as sensors and transducers. Meanwhile, advances in material science, fabrication techniques, and photonic sensing strategies endow optical microresonators with new functionalities, unique transduction mechanisms, and in some cases, unparalleled sensitivities...
August 2017: Advanced Materials
https://www.readbyqxmd.com/read/28616220/impact-of-seasonality-on-the-dynamics-of-native-vitamin-d-repletion-in-long-term-renal-transplant-patients
#9
Oliver J Ziff, Hugo Penny, Sharon Frame, Antonia Cronin, David Goldsmith
Background: Renal transplant recipients (RTRs) are often Vitamin D (VitD) depleted as a result of both chronic kidney disease and mandated sun avoidance behaviours. Repleting VitD may be warranted, but how, and for how long, is unknown, as is the impact of seasonality on the success of repletion. We investigated the impact of seasonality on VitD status following VitD repletion in a large cohort of stable, long-term RTRs. Methods: Serum 25-hydroxyvitamin D [25(OH)D] concentrations and bone biochemistry parameters were analysed from 102 VitD repletion courses in 98 RTRs that had undergone VitD repletion...
June 2017: Clinical Kidney Journal
https://www.readbyqxmd.com/read/28600438/human-rela-haploinsufficiency-results-in-autosomal-dominant-chronic-mucocutaneous-ulceration
#10
Yousef R Badran, Fatma Dedeoglu, Juan Manuel Leyva Castillo, Wayne Bainter, Toshiro K Ohsumi, Athos Bousvaros, Jeffrey D Goldsmith, Raif S Geha, Janet Chou
The treatment of chronic mucocutaneous ulceration is challenging, and only some patients respond selectively to inhibitors of tumor necrosis factor-α (TNF). TNF activates opposing pathways leading to caspase-8-mediated apoptosis as well as nuclear factor κB (NF-κB)-dependent cell survival. We investigated the etiology of autosomal-dominant, mucocutaneous ulceration in a family whose proband was dependent on anti-TNF therapy for sustained remission. A heterozygous mutation in RELA, encoding the NF-κB subunit RelA, segregated with the disease phenotype and resulted in RelA haploinsufficiency...
July 3, 2017: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28557617/analytic-validation-of-immunohistochemical-assays-a-comparison-of-laboratory-practices-before-and-after-introduction-of-an-evidence-based-guideline
#11
Patrick L Fitzgibbons, Jeffrey D Goldsmith, Rhona J Souers, Lisa A Fatheree, Keith E Volmar, Lauren N Stuart, Jan A Nowak, J Rex Astles, Raouf E Nakhleh
CONTEXT: - Laboratories must demonstrate analytic validity before any test can be used clinically, but studies have shown inconsistent practices in immunohistochemical assay validation. OBJECTIVE: - To assess changes in immunohistochemistry analytic validation practices after publication of an evidence-based laboratory practice guideline. DESIGN: - A survey on current immunohistochemistry assay validation practices and on the awareness and adoption of a recently published guideline was sent to subscribers enrolled in one of 3 relevant College of American Pathologists proficiency testing programs and to additional nonsubscribing laboratories that perform immunohistochemical testing...
May 30, 2017: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/28557616/analytic-validation-of-immunohistochemistry-assays-new-benchmark-data-from-a-survey-of-1085-laboratories
#12
Lauren N Stuart, Keith E Volmar, Jan A Nowak, Lisa A Fatheree, Rhona J Souers, Patrick L Fitzgibbons, Jeffrey D Goldsmith, J Rex Astles, Raouf E Nakhleh
CONTEXT: - A cooperative agreement between the College of American Pathologists (CAP) and the United States Centers for Disease Control and Prevention was undertaken to measure laboratories' awareness and implementation of an evidence-based laboratory practice guideline (LPG) on immunohistochemical (IHC) validation practices published in 2014. OBJECTIVE: - To establish new benchmark data on IHC laboratory practices. DESIGN: - A 2015 survey on IHC assay validation practices was sent to laboratories subscribed to specific CAP proficiency testing programs and to additional nonsubscribing laboratories that perform IHC testing...
May 30, 2017: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/28506242/an-imprinted-non-coding-genomic-cluster-at-14q32-defines-clinically-relevant-molecular-subtypes-in-osteosarcoma-across-multiple-independent-datasets
#13
Katherine E Hill, Andrew D Kelly, Marieke L Kuijjer, William Barry, Ahmed Rattani, Cassandra C Garbutt, Haydn Kissick, Katherine Janeway, Antonio Perez-Atayde, Jeffrey Goldsmith, Mark C Gebhardt, Mohamed S Arredouani, Greg Cote, Francis Hornicek, Edwin Choy, Zhenfeng Duan, John Quackenbush, Benjamin Haibe-Kains, Dimitrios Spentzos
BACKGROUND: A microRNA (miRNA) collection on the imprinted 14q32 MEG3 region has been associated with outcome in osteosarcoma. We assessed the clinical utility of this miRNA set and their association with methylation status. METHODS: We integrated coding and non-coding RNA data from three independent annotated clinical osteosarcoma cohorts (n = 65, n = 27, and n = 25) and miRNA and methylation data from one in vitro (19 cell lines) and one clinical (NCI Therapeutically Applicable Research to Generate Effective Treatments (TARGET) osteosarcoma dataset, n = 80) dataset...
May 15, 2017: Journal of Hematology & Oncology
https://www.readbyqxmd.com/read/28506149/a-short-and-distinct-time-window-for-recovery-of-arm-motor-control-early-after-stroke-revealed-with-a-global-measure-of-trajectory-kinematics
#14
Juan C Cortes, Jeff Goldsmith, Michelle D Harran, Jing Xu, Nathan Kim, Heidi M Schambra, Andreas R Luft, Pablo Celnik, John W Krakauer, Tomoko Kitago
BACKGROUND: Studies demonstrate that most arm motor recovery occurs within three months after stroke, when measured with standard clinical scales. Improvements on these measures, however, reflect a combination of recovery in motor control, increases in strength, and acquisition of compensatory strategies. OBJECTIVE: To isolate and characterize the time course of recovery of arm motor control over the first year poststroke. METHODS: Longitudinal study of 18 participants with acute ischemic stroke...
June 2017: Neurorehabilitation and Neural Repair
https://www.readbyqxmd.com/read/28491748/percutaneous-extraction-of-a-pulmonary-artery-catheter-inadvertently-sewn-to-the-right-atrial-wall
#15
Tyler P Rasmussen, Gary Goldsmith, Firas Zahr, Jay K Bhama, Prashant D Bhave
No abstract text is available yet for this article.
November 2016: HeartRhythm Case Reports
https://www.readbyqxmd.com/read/28482001/crimean-congo-hemorrhagic-fever-in-humanized-mice-reveals-glial-cells-as-primary-targets-of-neurological-infection
#16
Jessica R Spengler, M Kelly Keating, Anita K McElroy, Marko Zivcec, JoAnn D Coleman-McCray, Jessica R Harmon, Brigid C Bollweg, Cynthia S Goldsmith, Éric Bergeron, James G Keck, Sherif R Zaki, Stuart T Nichol, Christina F Spiropoulou
Crimean-Congo hemorrhagic fever (CCHF) is a tick-borne viral hemorrhagic disease seen exclusively in humans. Central nervous system (CNS) infection and neurological involvement have also been reported in CCHF. Here we inoculated NSGTM-SGM3 mice engrafted with human hematopoietic CD34+ stem cells with low passage CCHF virus strains isolated from human patients. Humanized mice develop lethal disease characterized by histopathological change in the liver and brain. To date, targets of neuroinfection and neuropathology have not been investigated in CCHF...
May 8, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28455732/using-public-participation-to-sample-trace-metals-in-lake-surface-sediments-the-opal-metals-survey
#17
S D Turner, N L Rose, B Goldsmith, J M Bearcock, C Scheib, H Yang
Members of the public in England were invited in 2010 to take part in a national metals survey, by collecting samples of littoral sediment from a standing water body for geochemical analysis. To our knowledge, this is the first national sediment metals survey using public participation and reveals a snapshot of the extent of metals contamination in ponds and lakes across England. Hg, Ni, Cu, Zn and Pb concentrations exceeding sediment quality guidelines for the health of aquatic biota are ubiquitous in ponds and lakes, not just in areas with a legacy of industrial activity...
May 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28430956/achieving-high-reliability-in-histology-%C3%A2-an-improvement-series-to-reduce-errors
#18
Yael K Heher, Yigu Chen, Sergey Pyatibrat, Edward Yoon, Jeffrey D Goldsmith, Kenneth E Sands
Objectives: Despite sweeping medical advances in other fields, histology processes have by and large remained constant over the past 175 years. Patient label identification errors are a known liability in the laboratory and can be devastating, resulting in incorrect diagnoses and inappropriate treatment. The objective of this study was to identify vulnerable steps in the histology workflow and reduce the frequency of labeling errors (LEs). Methods: In this 36-month study period, a numerical step key (SK) was developed to capture LEs...
November 1, 2016: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28334793/compound-heterozygous-mutations-in-the-gene-pigp-are-associated-with-early-infantile-epileptic-encephalopathy
#19
Devon L Johnstone, Thi-Tuyet-Mai Nguyen, Yoshiko Murakami, Kristin D Kernohan, Martine Tétreault, Claire Goldsmith, Asif Doja, Justin D Wagner, Lijia Huang, Taila Hartley, Anik St-Denis, Françoise le Deist, Jacek Majewski, Dennis E Bulman, Taroh Kinoshita, David A Dyment, Kym M Boycott, Philippe M Campeau
There are over 150 known human proteins which are tethered to the cell surface via glycosylphosphatidylinositol (GPI) anchors. These proteins play a variety of important roles in development, and particularly in neurogenesis. Not surprisingly, mutations in the GPI anchor biosynthesis and remodeling pathway cause a number of developmental disorders. This group of conditions has been termed inherited GPI deficiencies (IGDs), a subgroup of congenital disorders of glycosylation; they present with variable phenotypes, often including seizures, hypotonia and intellectual disability...
May 1, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28334392/validation-of-the-nih-toolbox-in-individuals-with-neurologic-disorders
#20
N E Carlozzi, S Goodnight, K B Casaletto, A Goldsmith, R K Heaton, A W K Wong, C M Baum, R Gershon, A W Heinemann, D S Tulsky
Objective: Individuals with spinal cord injury (SCI), traumatic brain injury (TBI), and stroke experience a variety of neurologically related deficits across multiple domains of function. The NIH Toolbox for the Assessment of Neurological and Behavioral Function (NIHTB) examines motor, sensation, cognition, and emotional functioning. The purpose of this paper is to establish the validity of the NIHTB in individuals with neurologic conditions. Methods: Community-dwelling individuals with SCI (n = 209), TBI (n = 184), or stroke (n = 211) completed the NIHTB...
March 18, 2017: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
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