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Timothy G Bromage, Youssef Idaghdour, Rodrigo S Lacruz, Thomas D Crenshaw, Olexandra Ovsiy, Björn Rotter, Klaus Hoffmeier, Friedemann Schrenk
[This corrects the article DOI: 10.1371/journal.pone.0145919.].
2024: PloS One
#2
Kolluru D Srikanth, Hajira Elahi, Praveen Chander, Halley R Washburn, Shayne Hassler, Juliet M Mwirigi, Moeno Kume, Jessica Loucks, Rohita Arjarapu, Rachel Hodge, Stephanie I Shiers, Ishwarya Sankaranarayanan, Hediye Erdjument-Bromage, Thomas A Neubert, Zachary T Campbell, Raehum Paik, Theodore J Price, Matthew B Dalva
UNLABELLED: Phosphorylation of hundreds of protein extracellular domains is mediated by two kinase families, yet the significance of these kinases is underexplored. Here, we find that the presynaptic release of the tyrosine directed-ectokinase, Vertebrate Lonesome Kinase (VLK/Pkdcc), is necessary and sufficient for the direct extracellular interaction between EphB2 and GluN1 at synapses, for phosphorylation of the ectodomain of EphB2, and for injury-induced pain. Pkdcc is an essential gene in the nervous system, and VLK is found in synaptic vesicles, and is released from neurons in a SNARE-dependent fashion...
March 18, 2024: bioRxiv
#3
JOURNAL ARTICLE
L Pritchard, S Keshoor, D Eley, D Beckett, A Bromage, R Knevel, J Satur, N Stormon
INTRODUCTION: Oral Health Therapists (OHTs) are a growing workforce globally, with skills in oral health prevention, treatment planning and management of disease. These professionals receive their training through a three-year undergraduate program which leads to the Bachelor of Oral Health degree in Australia and New Zealand. The aim of this study was to describe the learning environment for OHT students in Australia and New Zealand. OHT students were requested to complete the Dundee Ready Education Environment Measure (DREEM) to indicate their perceptions of the environment of their educational program...
March 13, 2024: European Journal of Dental Education: Official Journal of the Association for Dental Education in Europe
#4
JOURNAL ARTICLE
Agnieszka Kujawska, Sabri Bromage, Jose Augusto Simoes, Jūratė Zupkauskienė, Nicholas McMahon, Paweł Zalewski, Sławomir Kujawski
PURPOSE: The prevalence of hypertension (HTN) increases with age and there is a need for effective, evidence-based treatments for HTN among older adults. The objective of this study was to perform a network meta-analysis to evaluate the effectiveness of different forms of nutritional supplementation on reducing blood pressure in older adults. METHODS: A systematic review using PubMed and Clinical Key was performed to identify randomized controlled trials (RCTs) evaluating the effects of dietary supplements on blood pressure in adults older than 65 years of age...
February 29, 2024: Heliyon
#5
JOURNAL ARTICLE
P Cerrito, A Nava, D Radovčić, D Borić, L Cerrito, T Basdeo, G Ruggiero, D W Frayer, A P Kao, L Bondioli, L Mancini, T G Bromage
No abstract text is available yet for this article.
February 2024: Journal of the Royal Society, Interface
#6
JOURNAL ARTICLE
Women's input and decision-making in agriculture are associated with diet quality in rural Tanzania.
Isabel Madzorera, Lilia Bliznashka, Mia M Blakstad, Alexandra L Bellows, Chelsey R Canavan, Dominic Mosha, Sabri Bromage, Ramadhani A Noor, Patrick Webb, Shibani Ghosh, Joyce Ludovick Kinabo, Honorati Masanja, Wafaie W Fawzi
BACKGROUND: Women's empowerment is one critical pathway through which agriculture can impact women's nutrition; however, empirical evidence is still limited. We evaluated the associations of women's participation, input, and decision-making in key agricultural and household activities with women's diet quality. METHODS: We analyzed data from a cross-sectional study of 870 women engaged in homestead agriculture. We used food frequency questionnaires to assess women's diets and computed women's diet quality using the Prime Diet Quality Score (PDQS) (range 0-42), which captures healthy and unhealthy foods...
2023: Frontiers in Public Health
#7
JOURNAL ARTICLE
Murali Manoj Manoharan, Manohar Paneer, Karthikeyan Elavarasan, Kameshwaran Kannappan Punniyakoti
BACKGROUND: Postoperative pain management is vital to improve patient care. Successful postoperative pain relief is currently achieved only through NSAIDs and narcotics. OBJECTIVES: We compared dexmedetomidine and clonidine as additives to hyperbaric levobupivicaine 0.5% for the sub-arachnoid block (spinal anesthesia) concerning the onset time, duration of the block, hemodynamic changes, level of sedation intraoperatively and postoperatively and time taken for the first postoperative analgesic request and frequency...
August 2023: Anesthesiology and Pain Medicine
#8
RANDOMIZED CONTROLLED TRIAL
Chun-Xiu Li, Wen-Chao Ge, Kang-Ning Yang, Hua-Yong Zheng, Xiao-Wei Wang, Ye-Lai Wang, Jie Gao, Wen-Zhi Guo
OBJECTIVE: To study the effect of ultrasound-guided fascia iliaca compartment block on perioperative analgesia and postoperative complications in geriatric patients with hip fractures. METHODS: A total of 127 elderly patients undergoing hip fracture surgery from January 2021 to September 2021 were randomized to receive ultrasound-guided continuous fascia iliaca compartment block(group F) either intravenous analgesia control group(group C). There were 62 cases in group F, including 19 males and 43 females with an average age of (82...
November 25, 2023: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
#9
JOURNAL ARTICLE
Uttara Partap, Kamal Kant Sharma, Yogesh Marathe, Molin Wang, Sanaa Shaikh, Pradeep D'Costa, Gaurav Gupta, Sabri Bromage, Elena C Hemler, Nerges Mistry, Kevin C Kain, Yatin Dholakia, Wafaie W Fawzi
BACKGROUND: There remains a need to identify low-cost interventions to improve coronavirus disease 2019 (COVID-19) outcomes. Vitamin D and zinc play a role in respiratory infections and could hold value as part of therapeutic regimens. OBJECTIVES: To determine the effect of vitamin D or zinc supplementation on recovery from COVID-19. METHODS: We conducted a double-blind, randomly assigned 2 x 2 factorial placebo-controlled trial with 1:1:1:1 allocation ratio, enrolling nonpregnant adults with COVID-19 from hospitals in Mumbai and Pune, India (NCT04641195)...
August 2023: Current Developments in Nutrition
#10
JOURNAL ARTICLE
I A Begishev, C Dorrer, S-W Bahk, S Bucht, C Feng, M J Guardalben, C Jeon, C Mileham, R G Roides, M Spilatro, B Webb, D Weiner, J D Zuegel, J Bromage
Optical parametric chirped-pulse amplification (OPCPA) using high-energy Nd:glass lasers has the potential to produce ultra-intense pulses (>1023 W/cm2 ). We report on the performance of the final high-efficiency amplifier in an OPCPA system based on large-aperture (63 × 63-mm2 ) partially deuterated potassium dihydrogen phosphate (DKDP) crystals. The seed beam (180-nm bandwidth, 110 mJ) was provided by the preceding OPCPA stages. A maximum pump-to-signal conversion efficiency of 41% and signal energy up to 13 J were achieved with a 52-mm-long DKDP crystal due to the flattop super-Gaussian pump beam profile and flat-in-time pulse shape...
July 17, 2023: Optics Express
#11
JOURNAL ARTICLE
Joshua D Frenster, Hediye Erdjument-Bromage, Gabriele Stephan, Niklas Ravn-Boess, Shuai Wang, Wenke Liu, Devin Bready, Jordan Wilcox, Björn Kieslich, Manuel Jankovic, Caroline Wilde, Susanne Horn, Norbert Sträter, Ines Liebscher, Torsten Schöneberg, David Fenyo, Thomas A Neubert, Dimitris G Placantonakis
The adhesion G-protein-coupled receptor GPR133 (ADGRD1) supports growth of the brain malignancy glioblastoma. How the extracellular interactome of GPR133 in glioblastoma modulates signaling remains unknown. Here, we use affinity proteomics to identify the transmembrane protein PTK7 as an extracellular binding partner of GPR133 in glioblastoma. PTK7 binds the autoproteolytically generated N-terminal fragment of GPR133 and its expression in trans increases GPR133 signaling. This effect requires the intramolecular cleavage of GPR133 and PTK7's anchoring in the plasma membrane...
June 23, 2023: Cell Reports
#12
JOURNAL ARTICLE
Anna Rodina, Chao Xu, Chander S Digwal, Suhasini Joshi, Yogita Patel, Anand R Santhaseela, Sadik Bay, Swathi Merugu, Aftab Alam, Pengrong Yan, Chenghua Yang, Tanaya Roychowdhury, Palak Panchal, Liza Shrestha, Yanlong Kang, Sahil Sharma, Justina Almodovar, Adriana Corben, Mary L Alpaugh, Shanu Modi, Monica L Guzman, Teng Fei, Tony Taldone, Stephen D Ginsberg, Hediye Erdjument-Bromage, Thomas A Neubert, Katia Manova-Todorova, Meng-Fu Bryan Tsou, Jason C Young, Tai Wang, Gabriela Chiosis
Systems-level assessments of protein-protein interaction (PPI) network dysfunctions are currently out-of-reach because approaches enabling proteome-wide identification, analysis, and modulation of context-specific PPI changes in native (unengineered) cells and tissues are lacking. Herein, we take advantage of chemical binders of maladaptive scaffolding structures termed epichaperomes and develop an epichaperome-based 'omics platform, epichaperomics, to identify PPI alterations in disease. We provide multiple lines of evidence, at both biochemical and functional levels, demonstrating the importance of these probes to identify and study PPI network dysfunctions and provide mechanistically and therapeutically relevant proteome-wide insights...
June 23, 2023: Nature Communications
#13
JOURNAL ARTICLE
Sabri Bromage, Teresa T Fung, Sharon I Kirkpatrick, Walter C Willett
Lasschuijt, M. P. et al. Concept development and use of an automated food intake and eating behavior assessment method. Journal of Visualized Experiments. (168), e62144 (2021). Chung, J. et al. Design and evaluation of smart glasses for food intake and physical activity classification. Journal of Visualized Experiments. (132), e56633 (2018). Lucassen, D. A., Brouwer-Brolsma, E. M., van de Wiel, A. M., Siebelink, E., Feskens, E. J. Iterative development of an innovative smartphone-based dietary assessment tool: TRAQQ...
February 3, 2023: Journal of Visualized Experiments: JoVE
#14
JOURNAL ARTICLE
Enrico Ammirati, Laura Lupi, Matteo Palazzini, Michele Ciabatti, Valentina A Rossi, Piero Gentile, Aitor Uribarri, Chiara R Vecchio, Daniele Nassiacos, Alberto Cereda, Cristina Conca, Gabriele Tumminello, Nicolas Piriou, Coline Lelarge, Patrizia Pedrotti, Miriam Stucchi, Giovanni Peretto, Michele Galasso, Florent Huang, Umberto Ianni, Antonio Procopio, Gianluigi Saponara, Paolo Cimaglia, Daniela Tomasoni, Francesco Moroni, Annalisa Turco, Simone Sala, Giuseppe Di Tano, Entela Bollano, Claudio Moro, Antonio Abbate, Roberta Della Bona, Italo Porto, Stefano Carugo, Jeness Campodonico, Gianluca Pontone, Aurelia Grosu, Leonardo Bolognese, Jorge Salamanca, Pablo Diez-Villanueva, Krzysztof Ozieranski, Agata Tyminska, Loren Sardo Infirri, Daniel Bromage, Antonio Cannatà, Kimberly N Hong, Marianna Adamo, Giuseppina Quattrocchi, Alberto Foà, Luciano Potena, Andrea Garascia, Cristina Giannattasio, Eric D Adler, Gianfranco Sinagra, Frank Ruschitzka, Paolo G Camici, Marco Metra, Maurizio Pieroni
No abstract text is available yet for this article.
May 15, 2023: Circulation. Heart Failure
#15
JOURNAL ARTICLE
S Bucht, R G Roides, B Webb, D Haberberger, C Feng, D H Froula, J Bromage
Optical parametric chirped-pulse-amplification produces two broadband pulses, a signal and an idler, that can both provide peak powers >100 GW. In most cases the signal is used, but compressing the longer-wavelength idler opens up opportunities for experiments where the driving laser wavelength is a key parameter. This paper will describe several subsystems that were added to a petawatt class, Multi-Terawatt optical parametric amplifier line (MTW-OPAL) at the Laboratory for Laser Energetics to address two long-standing issues introduced by the use of the idler, angular dispersion, and spectral phase reversal...
February 27, 2023: Optics Express
#16
Gabriele Stephan, Hediye Erdjument-Bromage, Wenke Liu, Joshua D Frenster, Niklas Ravn-Boess, Devin Bready, Julia Cai, David Fenyo, Thomas Neubert, Dimitris G Placantonakis
GPR133 (ADGRD1) is an adhesion G protein-coupled receptor that signals through Gαs and is required for growth of glioblastoma (GBM), an aggressive brain malignancy. The regulation of GPR133 signaling is incompletely understood. Here, we use proximity biotinylation proteomics to identify ESYT1, a Ca 2+ -dependent mediator of endoplasmic reticulum-plasma membrane bridge formation, as an intracellular interactor of GPR133. ESYT1 knockdown or knockout increases GPR133 signaling, while its overexpression has the opposite effect, without altering GPR133 levels in the plasma membrane...
February 9, 2023: bioRxiv
#17
JOURNAL ARTICLE
Syed Sajjad Alam, Nighat Abbas, Ali Asgher, Muhammad Rafique, Khadijah Abid
BACKGROUND: Intra-thecal anaesthesia is the commonly preferred, block for surgeries of lower abdomen, perineal and lower limb. It is easy to administer and very economical but needs skills. Intrathecal use of local anaesthetics possesses a short duration of action and needs early use of rescue analgesia postoperatively. Objective was to assess the efficacy of Dexmedetomidine in adjuvant with bupivacaine for neuraxial anaesthesia and postoperative analgesic characteristics. It was a prospective comparative study, conducted at Anaesthesia Department, Liaquat National Hospital, Karachi from January to July 2020...
2022: Journal of Ayub Medical College, Abbottabad: JAMC
#18
RANDOMIZED CONTROLLED TRIAL
Davaasambuu Ganmaa, Sabri Bromage, Polyna Khudyakov, Sumiya Erdenenbaatar, Baigal Delgererekh, Adrian R Martineau
IMPORTANCE: Vitamin D deficiency (defined as 25-hydroxyvitamin D [25(OH)D] <20 ng/mL) is prevalent among children living in temperate climates and has been reported to associate independently with stunting, obesity, and early activation of the hypothalamic-pituitary-gonadal axis. Phase 3 randomized clinical trials to investigate the influence of long-term vitamin D replacement on growth, body composition, and pubertal development of school-aged children with vitamin D deficiency are lacking...
January 1, 2023: JAMA Pediatrics
#19
JOURNAL ARTICLE
E P Power, S Bucht, K R P Kafka, J Bromage, J D Zuegel
We used COMSOL Multiphysics to design a prototype actively cooled "flow-cell" substrate targeted at high-average-power applications, fabricated the prototype from cordierite ceramic, and tested the substrate under load in our thermal loading test stand. Sub-aperture testing revealed average-power handling up to 3.88-W/cm2 absorbed power density, in excellent agreement with model predictions. Gratings fabricated on 2-in.-diam cordierite coupons were subjected to laser-damage testing and showed a damage threshold of 250 mJ/cm2 ...
November 7, 2022: Optics Express
#20
JOURNAL ARTICLE
Kamal Kant Sharma, Uttara Partap, Nerges Mistry, Yogesh Marathe, Molin Wang, Sanaa Shaikh, Pradeep D'Costa, Gaurav Gupta, Sabri Bromage, Elena C Hemler, Kevin C Kain, Yatin Dholakia, Wafaie W Fawzi
INTRODUCTION: Presently, there are few population-level strategies to address SARS-CoV-2 infection except preventive measures such as vaccination. Micronutrient deficiency, particularly vitamin D and zinc deficiency, has been associated with dysregulated host responses, and may play an important role in COVID-19. METHODS AND ANALYSIS: We have designed a 2×2 factorial, randomised, double-blind, multi-centre placebo-controlled trial to evaluate the effect of vitamin D and zinc on COVID-19 outcomes in Maharashtra, India...
August 29, 2022: BMJ Open
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