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Sabri Bromage, Janet W Rich-Edwards, Daria Tselmen, Ana Baylin, Lisa A Houghton, Nachin Baasanjav, Davaasambuu Ganmaa
Many factors put Mongolians at risk of vitamin D deficiency. Despite low levels observed in Mongolian children and pregnant women, there are few data published on the vitamin D status of non-pregnant adults. Between summer 2011 and winter 2013, paired summer and winter blood samples were collected from 320 healthy men and women (20-58 years) living in eight Mongolian provinces. Mean serum 25(OH)D concentrations were 22.5 ng/mL (95% CI: 14.5, 32.5) in summer and 7.7 ng/mL (95% CI: 4.6, 10.8) in winter, with a distribution (<10/10-20/20-30/≥30 ng/mL) of 3...
2016: Nutrients
I Smolyar, T Bromage, M Wikelski
Large-scale patterns evident from satellite images of aeolian landforms on Earth and other planets; those of intermediate scale in marine and terrestrial sand ripples and sediment profiles; and small-scale patterns such as lamellae in the bones of vertebrates and annuli in fish scales are each represented by layers of different thicknesses and lengths. Layered patterns are important because they form a record of the state of internal and external factors that regulate pattern formation in these geological and biological systems...
March 2016: Heliyon
Daniel I Bromage, Daniel A Jones, Krishnaraj S Rathod, Claire Grout, M Bilal Iqbal, Pitt Lim, Ajay Jain, Sundeep S Kalra, Tom Crake, Zoe Astroulakis, Mick Ozkor, Roby D Rakhit, Charles J Knight, Miles C Dalby, Iqbal S Malik, Anthony Mathur, Simon Redwood, Philip A MacCarthy, Andrew Wragg
BACKGROUND: ST-segment elevation myocardial infarction is increasingly common in octogenarians, and optimal management in this cohort is uncertain. This study aimed to describe the outcomes of octogenarians with ST-segment elevation myocardial infarction treated by primary percutaneous coronary intervention. METHODS AND RESULTS: We analyzed 10 249 consecutive patients with ST-segment elevation myocardial infarction treated with primary percutaneous coronary intervention between 2005 and 2011 at 8 tertiary cardiac centers across London, United Kingdom...
June 2016: Journal of the American Heart Association
M P Valdivia, D Stutman, C Stoeckl, W Theobald, C Mileham, I A Begishev, J Bromage, S P Regan
X-ray phase-contrast techniques can measure electron density gradients in high-energy-density plasmas through refraction induced phase shifts. An 8 keV Talbot-Lau interferometer consisting of free standing ultrathin gratings was deployed at an ultra-short, high-intensity laser system using K-shell emission from a 1-30 J, 8 ps laser pulse focused on thin Cu foil targets. Grating survival was demonstrated for 30 J, 8 ps laser pulses. The first x-ray deflectometry images obtained under laser backlighting showed up to 25% image contrast and thus enabled detection of electron areal density gradients with a maximum value of 8...
February 2016: Review of Scientific Instruments
Timothy G Bromage, Youssef Idaghdour, Rodrigo S Lacruz, Thomas D Crenshaw, Olexandra Ovsiy, Björn Rotter, Klaus Hoffmeier, Friedemann Schrenk
The paradigm of chronobiology is based almost wholly upon the daily biological clock, or circadian rhythm, which has been the focus of intense molecular, cellular, pharmacological, and behavioral, research. However, the circadian rhythm does not explain biological timings related to fundamental aspects of life history such as rates of tissue/organ/body size development and control of the timing of life stages such as gestation length, age at maturity, and lifespan. This suggests that another biological timing mechanism is at work...
2016: PloS One
A Malik, D I Bromage, Z He, L Candilio, A Hamarneh, S Taferner, S M Davidson, D M Yellon
No abstract text is available yet for this article.
October 20, 2015: Cardiovascular Drugs and Therapy
Jahnabee Sarma, P Shankara Narayana, P Ganapathi, M C Shivakumar
INTRODUCTION: Intrathecal clonidine or dexmedetomidine has improved the quality of spinal anesthesia, this clinical study was undertaken to assess the behavior of intrathecal clonidine as an adjuvant to bupivacaine in augmenting sensory block in patients undergoing lower limb surgeries. MATERIALS AND METHODS: We studied 150 patients, between 18 and 60 years of age, patients were randomly divided into three groups of 50 each Group B: 0.5% bupivacaine 15 mg + 0.5 ml normal saline Group C: 0...
May 2015: Anesthesia, Essays and Researches
M Bilal Iqbal, Ramzi Khamis, Charles Ilsley, Ghada Mikhail, Tom Crake, Sam Firoozi, Sundeep Kalra, Charles Knight, Andrew Archbold, Pitt Lim, Anthony Mathur, Pascal Meier, Roby D Rakhit, Simon Redwood, Mark Whitbread, Dan Bromage, Krishna Rathod, Daniel A Jones, Andrew Wragg, Miles Dalby, Phil MacCarthy, Iqbal S Malik
BACKGROUND: Primary percutaneous coronary intervention (PPCI) is the treatment of choice for ST-segment-elevation myocardial infarction. Resources are limited during out of working hours (OWH). Whether PPCI outside working hours is associated with worse outcomes and whether outcomes have improved over time are unknown. METHODS AND RESULTS: We analyzed 11 466 patients undergoing PPCI between 2004 and 2011 at all 8 tertiary cardiac centers in London, United Kingdom...
June 2015: Circulation. Cardiovascular Interventions
Udita Naithani, Mahendra Singh Meena, Sunanda Gupta, Khemraj Meena, Lalatendu Swain, D S Pradeep
BACKGROUND AND AIMS: Effect of intrathecal dexmedetomidine as an adjuvant to isobaric ropivacaine in spinal anesthesia for abdominal hysterectomy is not much investigated. The objective was to assess the dose dependent effect of dexmedetomidine (3 mcg vs 5 mcg) as an adjunct to isobaric ropivacaine in spinal anesthesia. MATERIALS AND METHODS: Forty selected female patients were randomized to receive intrathecal 0.5% isobaric ropivacaine (15 mg) with dexmedetomidine 3 mcg (Group D3) or 5 mcg (Group D5) in spinal anesthesia for abdominal hysterectomy...
January 2015: Journal of Anaesthesiology, Clinical Pharmacology
M Bilal Iqbal, Charles Ilsley, Tito Kabir, Robert Smith, Rebecca Lane, Mark Mason, Piers Clifford, Tom Crake, Sam Firoozi, Sundeep Kalra, Charles Knight, Pitt Lim, Iqbal S Malik, Anthony Mathur, Pascal Meier, Roby D Rakhit, Simon Redwood, Mark Whitbread, Dan Bromage, Krishna Rathod, Philip MacCarthy, Miles Dalby
BACKGROUND: It is estimated that up to two thirds of patients presenting with ST-segment-elevation myocardial infarction have multivessel disease. The optimal strategy for treating nonculprit disease is currently under debate. This study provides a real-world analysis comparing a strategy of culprit-vessel intervention (CVI) versus multivessel intervention at the time of primary percutaneous coronary intervention in patients with ST-segment-elevation myocardial infarction. METHODS AND RESULTS: We compared CVI versus multivessel intervention in 3984 patients with multivessel disease undergoing primary percutaneous coronary intervention between 2004 and 2011 at all 8 tertiary cardiac centers in London...
November 2014: Circulation. Cardiovascular Quality and Outcomes
Hem Anand Nayagam, N Ratan Singh, H Shanti Singh
BACKGROUND AND AIMS: The potentiating effect of short acting lipophilic opioid fentanyl and a more selective α2 agonist dexmedetomidine is used to reduce the dose requirement of bupivacaine and its adverse effects and also to prolong analgesia. In this study, we aimed to find out whether quality of anaesthesia is better with low dose bupivacaine and fentanyl or with low dose bupivacaine and dexmedetomidine. METHODS: This prospective randomised double-blinded study was carried out in a tertiary health care centre on 150 patients by randomly allocating them into two groups using a computer generated randomisation table...
July 2014: Indian Journal of Anaesthesia
C Dorrer, R G Roides, J Bromage, J D Zuegel
Self-phase modulation limits the amplification of short optical pulses because of spatial self-focusing and spectral broadening. Cascaded nonlinearities are theoretically and experimentally investigated for intracavity nonlinearity compensation in a neodymium-doped yttrium-lithium-fluoride (Nd:YLF) regenerative amplifier. Experimental results are in good agreement with simulations. Spectral broadening is significantly reduced, allowing for efficient amplification in a Nd:YLF power amplifier.
August 1, 2014: Optics Letters
M Bilal Iqbal, Aruna Arujuna, Charles Ilsley, Andrew Archbold, Tom Crake, Sam Firoozi, Sundeep Kalra, Charles Knight, Pitt Lim, Iqbal S Malik, Anthony Mathur, Pascal Meier, Roby D Rakhit, Simon Redwood, Mark Whitbread, Dan Bromage, Krishna Rathod, Andrew Wragg, Philip MacCarthy, Miles Dalby
BACKGROUND: Compared with transfemoral access, transradial access (TRA) for percutaneous coronary intervention is associated with reduced risk of bleeding and vascular complications. Studies suggest that TRA may reduce mortality in patients with ST-segment-elevation myocardial infarction. However, there are few data on the effect of TRA on mortality, specifically, in patients with non-ST-segment-elevation myocardial infarction. METHODS AND RESULTS: We analyzed 10 095 consecutive patients with non-ST-segment-elevation myocardial infarction treated with percutaneous coronary intervention between 2005 and 2011 in all 8 tertiary cardiac centers in London, United Kingdom...
August 2014: Circulation. Cardiovascular Interventions
Anna Rodina, Tony Taldone, Yanlong Kang, Pallav D Patel, John Koren, Pengrong Yan, Erica M DaGama Gomes, Chenghua Yang, Maulik R Patel, Liza Shrestha, Stefan O Ochiana, Cristina Santarossa, Ronnie Maharaj, Alexander Gozman, Marc B Cox, Hediye Erdjument-Bromage, Ronald C Hendrickson, Leandro Cerchietti, Ari Melnick, Monica L Guzman, Gabriela Chiosis
Heat shock protein 70 (Hsp70) is a family of proteins with key roles in regulating malignancy. Cancer cells rely on Hsp70 to inhibit apoptosis, regulate senescence and autophagy, and maintain the stability of numerous onco-proteins. Despite these important biological functions in cancer, robust chemical tools that enable the analysis of the Hsp70-regulated proteome in a tumor-by-tumor manner are yet unavailable. Here we take advantage of a recently reported Hsp70 ligand to design and develop an affinity purification chemical toolset for potential use in the investigation of the endogenous Hsp70-interacting proteome in cancer...
August 15, 2014: ACS Chemical Biology
Chilkunda N Dinesh, N A Sai Tej, Bevinaguddaiah Yatish, Vinayak S Pujari, R M Mohan Kumar, Chadalawada V R Mohan
BACKGROUND AND OBJECTIVES: The present study was designed to evaluate the effect of intravenous dexmedetomidine on spinal anesthesia with 0.5% of hyperbaric bupivacaine. MATERIALS AND METHODS: One hundred American Society of Anesthesiologists (ASA) physical status I/II patients undergoing elective surgeries under spinal anesthesia were randomized into two groups of 50 each. Immediately after subarachnoid block with 3 ml of 0.5% hyperbaric bupivacaine, patients in group D received a loading dose of 1 μg/kg of dexmedetomidine intravenously by infusion pump over 10 min followed by a maintenance dose of 0...
April 2014: Saudi Journal of Anaesthesia
N D Karslı, D Subaşi, B Terzioğlu, G Turan, O Ekinci
BACKGROUND: Levobupivacaine use is progressively increased for intrathecal anesthesia in transurethral resections. The aim was to determine ED(50) and ED(95) of intrathecal isobaric levobupivacaine by addition of 25 mcg fentanyl for patients undergoing transurethral resections. METHODS: A total of 100 patients undergoing transurethral resections with ASA I-III, were randomized to groups receiving intrathecal 0.5% isobaric levobupivacaine in doses of 6, 8, 10, 12 or 14 mg in equal volumes with 25 mcg intrathecal fentanyl addition...
January 2015: Drug Research
Seung-Whan Bahk, Jake Bromage, Jonathan D Zuegel
Conventional lens-based image relays introduce radial group delay that significantly reduces focal-spot intensity of ultra-broadband short pulses. A direct compensation scheme that can be used with conventional singlet image relays is proposed. The compensation scheme is based on using two negative lenses embedded within an Offner imaging system. The setup allows a single-pass configuration and eliminates the need for polarization switching optics. The performance of this setup is calculated using ray tracing...
February 15, 2014: Optics Letters
J B Oliver, J Bromage, C Smith, D Sadowski, C Dorrer, A L Rigatti
Large-aperture deposition of high-laser-damage-threshold, low-dispersion optical coatings for 15 femtosecond pulses have been developed using plasma-ion-assisted electron-beam evaporation. Coatings are demonstrated over 10 in. aperture substrates.
February 1, 2014: Applied Optics
Cristian Acosta, Laiche Djouhri, Roger Watkins, Carol Berry, Kirsty Bromage, Sally N Lawson
Ongoing/spontaneous pain behavior is associated with ongoing/spontaneous firing (SF) in adult DRG C-fiber nociceptors (Djouhri et al., 2006). Causes of this SF are not understood. We show here that conducting (sometimes called uninjured) C-nociceptors in neuropathic pain models with more hyperpolarized resting membrane potentials (Ems) have lower SF rates. Understanding the control of their Ems may therefore be important for limiting pathological pain. We report that TREK2, a leak K(+) channel, is selectively expressed in IB4 binding rat C-nociceptors...
January 22, 2014: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
Rosario Castro, Erin Bromage, Beatriz Abós, Jaime Pignatelli, Aitor González Granja, Alfonso Luque, Carolina Tafalla
Chemokine receptor CCR7, the receptor for both CCL19 and CCL21 chemokines, regulates the recruitment and clustering of circulating leukocytes to secondary lymphoid tissues, such as lymph nodes and Peyer's patches. Even though teleost fish do not have either of these secondary lymphoid structures, we have recently reported a homolog to CCR7 in rainbow trout (Oncorhynchus mykiss). In the present work, we have studied the distribution of leukocytes bearing extracellular CCR7 in naive adult tissues by flow cytometry, observing that among the different leukocyte populations, the highest numbers of cells with membrane (mem)CCR7 were recorded in the gill (7...
February 1, 2014: Journal of Immunology: Official Journal of the American Association of Immunologists
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