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https://www.readbyqxmd.com/read/28692301/high-dose-vitamin-d3-during-tuberculosis-treatment-in-mongolia-a-randomised-controlled-trial
#1
Davaasambuu Ganmaa, Baatar Munkhzul, Wafaie Fawzi, Donna Spiegelman, Walter C Willett, Purev Bayasgalan, Erkhembayar Baasansuren, Burneebaatar Buyankhishig, Sereeter Oyun-Erdene, David A Jolliffe, Theodoros Xenakis, Sabri Bromage, Barry R Bloom, Adrian R Martineau
RATIONALE: Existing trials of adjunctive vitamin D in the treatment of pulmonary tuberculosis (PTB) are variously limited by small sample sizes, inadequate dosing regimens and high baseline vitamin D status among participants. Comprehensive analyses of the effects of genetic variation in the vitamin D pathway on response to vitamin D supplementation are lacking. OBJECTIVES: To determine the effect of high-dose vitamin D3 on response to antimicrobial therapy for PTB and to evaluate the influence of single nucleotide polymorphisms (SNPs) in vitamin D pathway genes on response to adjunctive vitamin D3...
July 10, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28441747/associations-between-diet-and-toenail-arsenic-concentration-among-pregnant-women-in-bangladesh-a-prospective-study
#2
Pi-I D Lin, Sabri Bromage, Md Golam Mostofa, Joseph Allen, Emily Oken, Molly L Kile, David C Christiani
This prospective study evaluated the relationship between long-term dietary habits and total arsenic (As) concentration in toenail clippings in a cohort of 1616 pregnant women in the Bangladeshi administrative regions of Sirajdikhan and Pabna Sadar. Diet was assessed at Gestation Week 28 and at Postpartum Month 1, using a locally-validated dish-based semi-quantitative food-frequency questionnaire. Toenail As concentration was analyzed by microwave-assisted acid digestion and inductively coupled plasma mass spectrometry...
April 23, 2017: Nutrients
https://www.readbyqxmd.com/read/28437959/high-average-power-2-%C3%AE-m-femtosecond-optical-parametric-oscillator-synchronously-pumped-by-a-thin-disk-mode-locked-laser
#3
T Petersen, J D Zuegel, J Bromage
A high-energy, extended-cavity femtosecond BiBO optical parametric oscillator synchronously pumped by a 1.0-ps, 1030-nm Yb:YAG, thin-disk pump laser is presented. The oscillator operated near degeneracy in a noncollinear interaction geometry, producing signal wavelength tunability from 1.99 to 2.20 μm. The signal pulses have an average power exceeding 2 W, producing 455-fs pulses at 7.08 MHz with energies up to 350 nJ, showing increased potential for tunable sources of scalable ultrafast pulses in the infrared...
April 17, 2017: Optics Express
https://www.readbyqxmd.com/read/28075369/validation-of-a-dish-based-semiquantitative-food-questionnaire-in-rural-bangladesh
#4
Pi-I D Lin, Sabri Bromage, Md Golam Mostofa, Joseph Allen, Emily Oken, Molly L Kile, David C Christiani
A locally validated tool was needed to evaluate long-term dietary intake in rural Bangladesh. We assessed the validity of a 42-item dish-based semi-quantitative food frequency questionnaire (FFQ) using two 3-day food diaries (FDs). We selected a random subset of 47 families (190 participants) from a longitudinal arsenic biomonitoring study in Bangladesh to administer the FFQ. Two 3-day FDs were completed by the female head of the households and we used an adult male equivalent method to estimate the FD for the other participants...
January 10, 2017: Nutrients
https://www.readbyqxmd.com/read/27988978/early-surgical-outcomes-and-oncological-results-of-robot-assisted-partial-nephrectomy-a-multicentre-study
#5
Rajan Veeratterapillay, Sanjai K Addla, Clare Jelley, John Bailie, David Rix, Steve Bromage, Neil Oakley, Robin Weston, Naeem A Soomro
OBJECTIVE: To describe a multicentre experience of robot-assisted partial nephrectomy (RAPN) in northern England, with focus on early surgical outcomes and oncological results. PATIENTS AND METHODS: All consecutive patients undergoing RAPN at four tertiary referral centres in northern England in the period 2012-2015 were included for analysis. RAPN was performed via a transperitoneal approach using a standardized technique. Prospective data collection was performed to capture preoperative characteristics (including R...
December 18, 2016: BJU International
https://www.readbyqxmd.com/read/27910458/publisher-s-note-talbot-lau-x-ray-deflectometer-electron-density-diagnostic-for-laser-and-pulsed-power-high-energy-density-plasma-experiments-invited-rev-sci-instrum-87-11d501-2016
#6
M P Valdivia, D Stutman, C Stoeckl, C Mileham, I A Begishev, W Theobald, J Bromage, S P Regan, S R Klein, G Muñoz-Cordovez, M Vescovi, V Valenzuela-Villaseca, F Veloso
No abstract text is available yet for this article.
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910439/talbot-lau-x-ray-deflectometer-electron-density-diagnostic-for-laser-and-pulsed-power-high-energy-density-plasma-experiments-invited
#7
M P Valdivia, D Stutman, C Stoeckl, C Mileham, I A Begishev, W Theobald, J Bromage, S P Regan, S R Klein, G Muñoz-Cordovez, M Vescovi, V Valenzuela-Villaseca, F Veloso
Talbot-Lau X-ray deflectometry (TXD) has been developed as an electron density diagnostic for High Energy Density (HED) plasmas. The technique can deliver x-ray refraction, attenuation, elemental composition, and scatter information from a single Moiré image. An 8 keV Talbot-Lau interferometer was deployed using laser and x-pinch backlighters. Grating survival and electron density mapping were demonstrated for 25-29 J, 8-30 ps laser pulses using copper foil targets. Moiré pattern formation and grating survival were also observed using a copper x-pinch driven at 400 kA, ∼1 kA/ns...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27669291/seasonal-epidemiology-of-serum-25-hydroxyvitamin-d-concentrations-among-healthy-adults-living-in-rural-and-urban-areas-in-mongolia
#8
Sabri Bromage, Janet W Rich-Edwards, Daria Tselmen, Ana Baylin, Lisa A Houghton, Nachin Baasanjav, Davaasambuu Ganmaa
Many factors put Mongolians at risk of vitamin D deficiency. Despite low levels observed in Mongolian children and pregnant women, there are few data published on the vitamin D status of non-pregnant adults. Between summer 2011 and winter 2013, paired summer and winter blood samples were collected from 320 healthy men and women (20-58 years) living in eight Mongolian provinces. Mean serum 25(OH)D concentrations were 22.5 ng/mL (95% CI: 14.5, 32.5) in summer and 7.7 ng/mL (95% CI: 4.6, 10.8) in winter, with a distribution (<10/10-20/20-30/≥30 ng/mL) of 3...
September 23, 2016: Nutrients
https://www.readbyqxmd.com/read/27441261/quantification-of-layered-patterns-with-structural-anisotropy-a-comparison-of-biological-and-geological-systems
#9
I Smolyar, T Bromage, M Wikelski
Large-scale patterns evident from satellite images of aeolian landforms on Earth and other planets; those of intermediate scale in marine and terrestrial sand ripples and sediment profiles; and small-scale patterns such as lamellae in the bones of vertebrates and annuli in fish scales are each represented by layers of different thicknesses and lengths. Layered patterns are important because they form a record of the state of internal and external factors that regulate pattern formation in these geological and biological systems...
March 2016: Heliyon
https://www.readbyqxmd.com/read/27353606/outcome-of-1051-octogenarian-patients-with-st-segment-elevation-myocardial-infarction-treated-with-primary-percutaneous-coronary-intervention-observational-cohort-from-the-london-heart-attack-group
#10
Daniel I Bromage, Daniel A Jones, Krishnaraj S Rathod, Claire Grout, M Bilal Iqbal, Pitt Lim, Ajay Jain, Sundeep S Kalra, Tom Crake, Zoe Astroulakis, Mick Ozkor, Roby D Rakhit, Charles J Knight, Miles C Dalby, Iqbal S Malik, Anthony Mathur, Simon Redwood, Philip A MacCarthy, Andrew Wragg
BACKGROUND: ST-segment elevation myocardial infarction is increasingly common in octogenarians, and optimal management in this cohort is uncertain. This study aimed to describe the outcomes of octogenarians with ST-segment elevation myocardial infarction treated by primary percutaneous coronary intervention. METHODS AND RESULTS: We analyzed 10 249 consecutive patients with ST-segment elevation myocardial infarction treated with primary percutaneous coronary intervention between 2005 and 2011 at 8 tertiary cardiac centers across London, United Kingdom...
June 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/26931847/an-x-ray-backlit-talbot-lau-deflectometer-for-high-energy-density-electron-density-diagnostics
#11
M P Valdivia, D Stutman, C Stoeckl, W Theobald, C Mileham, I A Begishev, J Bromage, S P Regan
X-ray phase-contrast techniques can measure electron density gradients in high-energy-density plasmas through refraction induced phase shifts. An 8 keV Talbot-Lau interferometer consisting of free standing ultrathin gratings was deployed at an ultra-short, high-intensity laser system using K-shell emission from a 1-30 J, 8 ps laser pulse focused on thin Cu foil targets. Grating survival was demonstrated for 30 J, 8 ps laser pulses. The first x-ray deflectometry images obtained under laser backlighting showed up to 25% image contrast and thus enabled detection of electron areal density gradients with a maximum value of 8...
February 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/26735517/the-swine-plasma-metabolome-chronicles-many-days-biological-timing-and-functions-linked-to-growth
#12
Timothy G Bromage, Youssef Idaghdour, Rodrigo S Lacruz, Thomas D Crenshaw, Olexandra Ovsiy, Björn Rotter, Klaus Hoffmeier, Friedemann Schrenk
The paradigm of chronobiology is based almost wholly upon the daily biological clock, or circadian rhythm, which has been the focus of intense molecular, cellular, pharmacological, and behavioral, research. However, the circadian rhythm does not explain biological timings related to fundamental aspects of life history such as rates of tissue/organ/body size development and control of the timing of life stages such as gestation length, age at maturity, and lifespan. This suggests that another biological timing mechanism is at work...
2016: PloS One
https://www.readbyqxmd.com/read/26482377/exogenous-sdf-1%C3%AE-protects-human-myocardium-from-hypoxia-reoxygenation-injury-via-cxcr4
#13
A Malik, D I Bromage, Z He, L Candilio, A Hamarneh, S Taferner, S M Davidson, D M Yellon
No abstract text is available yet for this article.
October 20, 2015: Cardiovascular Drugs and Therapy
https://www.readbyqxmd.com/read/26417127/a-comparative-study-of-intrathecal-clonidine-and-dexmedetomidine-on-characteristics-of-bupivacaine-spinal-block-for-lower-limb-surgeries
#14
Jahnabee Sarma, P Shankara Narayana, P Ganapathi, M C Shivakumar
INTRODUCTION: Intrathecal clonidine or dexmedetomidine has improved the quality of spinal anesthesia, this clinical study was undertaken to assess the behavior of intrathecal clonidine as an adjuvant to bupivacaine in augmenting sensory block in patients undergoing lower limb surgeries. MATERIALS AND METHODS: We studied 150 patients, between 18 and 60 years of age, patients were randomly divided into three groups of 50 each Group B: 0.5% bupivacaine 15 mg + 0.5 ml normal saline Group C: 0...
May 2015: Anesthesia, Essays and Researches
https://www.readbyqxmd.com/read/26038482/time-trend-analyses-of-bleeding-and-mortality-after-primary-percutaneous-coronary-intervention-during-out-of-working-hours-versus-in-working-hours-an-observational-study-of-11%C3%A2-466-patients
#15
COMPARATIVE STUDY
M Bilal Iqbal, Ramzi Khamis, Charles Ilsley, Ghada Mikhail, Tom Crake, Sam Firoozi, Sundeep Kalra, Charles Knight, Andrew Archbold, Pitt Lim, Anthony Mathur, Pascal Meier, Roby D Rakhit, Simon Redwood, Mark Whitbread, Dan Bromage, Krishna Rathod, Daniel A Jones, Andrew Wragg, Miles Dalby, Phil MacCarthy, Iqbal S Malik
BACKGROUND: Primary percutaneous coronary intervention (PPCI) is the treatment of choice for ST-segment-elevation myocardial infarction. Resources are limited during out of working hours (OWH). Whether PPCI outside working hours is associated with worse outcomes and whether outcomes have improved over time are unknown. METHODS AND RESULTS: We analyzed 11 466 patients undergoing PPCI between 2004 and 2011 at all 8 tertiary cardiac centers in London, United Kingdom...
June 2015: Circulation. Cardiovascular Interventions
https://www.readbyqxmd.com/read/25788777/dose-dependent-effect-of-intrathecal-dexmedetomidine-on-isobaric-ropivacaine-in-spinal-anesthesia-for-abdominal-hysterectomy-effect-on-block-characteristics-and-hemodynamics
#16
Udita Naithani, Mahendra Singh Meena, Sunanda Gupta, Khemraj Meena, Lalatendu Swain, D S Pradeep
BACKGROUND AND AIMS: Effect of intrathecal dexmedetomidine as an adjuvant to isobaric ropivacaine in spinal anesthesia for abdominal hysterectomy is not much investigated. The objective was to assess the dose dependent effect of dexmedetomidine (3 mcg vs 5 mcg) as an adjunct to isobaric ropivacaine in spinal anesthesia. MATERIALS AND METHODS: Forty selected female patients were randomized to receive intrathecal 0.5% isobaric ropivacaine (15 mg) with dexmedetomidine 3 mcg (Group D3) or 5 mcg (Group D5) in spinal anesthesia for abdominal hysterectomy...
January 2015: Journal of Anaesthesiology, Clinical Pharmacology
https://www.readbyqxmd.com/read/25371542/culprit-vessel-versus-multivessel-intervention-at-the-time-of-primary-percutaneous-coronary-intervention-in-patients-with-st-segment-elevation-myocardial-infarction-and-multivessel-disease-real-world-analysis-of-3984-patients-in-london
#17
RANDOMIZED CONTROLLED TRIAL
M Bilal Iqbal, Charles Ilsley, Tito Kabir, Robert Smith, Rebecca Lane, Mark Mason, Piers Clifford, Tom Crake, Sam Firoozi, Sundeep Kalra, Charles Knight, Pitt Lim, Iqbal S Malik, Anthony Mathur, Pascal Meier, Roby D Rakhit, Simon Redwood, Mark Whitbread, Dan Bromage, Krishna Rathod, Philip MacCarthy, Miles Dalby
BACKGROUND: It is estimated that up to two thirds of patients presenting with ST-segment-elevation myocardial infarction have multivessel disease. The optimal strategy for treating nonculprit disease is currently under debate. This study provides a real-world analysis comparing a strategy of culprit-vessel intervention (CVI) versus multivessel intervention at the time of primary percutaneous coronary intervention in patients with ST-segment-elevation myocardial infarction. METHODS AND RESULTS: We compared CVI versus multivessel intervention in 3984 patients with multivessel disease undergoing primary percutaneous coronary intervention between 2004 and 2011 at all 8 tertiary cardiac centers in London...
November 2014: Circulation. Cardiovascular Quality and Outcomes
https://www.readbyqxmd.com/read/25197111/a-prospective-randomised-double-blind-study-of-intrathecal-fentanyl-and-dexmedetomidine-added-to-low-dose-bupivacaine-for-spinal-anesthesia-for-lower-abdominal-surgeries
#18
Hem Anand Nayagam, N Ratan Singh, H Shanti Singh
BACKGROUND AND AIMS: The potentiating effect of short acting lipophilic opioid fentanyl and a more selective α2 agonist dexmedetomidine is used to reduce the dose requirement of bupivacaine and its adverse effects and also to prolong analgesia. In this study, we aimed to find out whether quality of anaesthesia is better with low dose bupivacaine and fentanyl or with low dose bupivacaine and dexmedetomidine. METHODS: This prospective randomised double-blinded study was carried out in a tertiary health care centre on 150 patients by randomly allocating them into two groups using a computer generated randomisation table...
July 2014: Indian Journal of Anaesthesia
https://www.readbyqxmd.com/read/25078204/self-phase-modulation-compensation-in-a-regenerative-amplifier-using-cascaded-second-order-nonlinearities
#19
C Dorrer, R G Roides, J Bromage, J D Zuegel
Self-phase modulation limits the amplification of short optical pulses because of spatial self-focusing and spectral broadening. Cascaded nonlinearities are theoretically and experimentally investigated for intracavity nonlinearity compensation in a neodymium-doped yttrium-lithium-fluoride (Nd:YLF) regenerative amplifier. Experimental results are in good agreement with simulations. Spectral broadening is significantly reduced, allowing for efficient amplification in a Nd:YLF power amplifier.
August 1, 2014: Optics Letters
https://www.readbyqxmd.com/read/24963013/radial-versus-femoral-access-is-associated-with-reduced-complications-and-mortality-in-patients-with-non-st-segment-elevation-myocardial-infarction-an-observational-cohort-study-of-10-095-patients
#20
MULTICENTER STUDY
M Bilal Iqbal, Aruna Arujuna, Charles Ilsley, Andrew Archbold, Tom Crake, Sam Firoozi, Sundeep Kalra, Charles Knight, Pitt Lim, Iqbal S Malik, Anthony Mathur, Pascal Meier, Roby D Rakhit, Simon Redwood, Mark Whitbread, Dan Bromage, Krishna Rathod, Andrew Wragg, Philip MacCarthy, Miles Dalby
BACKGROUND: Compared with transfemoral access, transradial access (TRA) for percutaneous coronary intervention is associated with reduced risk of bleeding and vascular complications. Studies suggest that TRA may reduce mortality in patients with ST-segment-elevation myocardial infarction. However, there are few data on the effect of TRA on mortality, specifically, in patients with non-ST-segment-elevation myocardial infarction. METHODS AND RESULTS: We analyzed 10 095 consecutive patients with non-ST-segment-elevation myocardial infarction treated with percutaneous coronary intervention between 2005 and 2011 in all 8 tertiary cardiac centers in London, United Kingdom...
August 2014: Circulation. Cardiovascular Interventions
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