keyword
https://read.qxmd.com/read/37956741/exploring-hd-tdcs-effect-on-%C3%AE-opioid-receptor-and-pain-sensitivity-in-temporomandibular-disorder-a-pilot-randomized-clinical-trial-study
#21
JOURNAL ARTICLE
Dajung J Kim, Thiago D Nascimento, Manyoel Lim, Theodora Danciu, Jon-Kar Zubieta, Peter J H Scott, Robert Koeppe, Niko Kaciroti, Alexandre F DaSilva
This study explored the association between experimentally-induced pain sensitivity and µ-opioid receptor (μOR) availability in patients with temporomandibular disorder (TMD) and further investigated any changes in the pain and μOR availability following high-definition transcranial direct current stimulation (HD-tDCS) over the primary motor cortex (M1) with pilot randomized clinical trials. Seven patients with TMD completed either active (n = 3) or sham treatment (n = 4) for 10 daily sessions and underwent positron emission tomography (PET) scans with [11 C]carfentanil, a selective μOR agonist, a week before and after treatment...
November 11, 2023: Journal of Pain
https://read.qxmd.com/read/37927455/the-effectiveness-of-hyaluronic-acid-in-reducing-adverse-effects-associated-with-inhaled-hypertonic-saline-therapy-in-patients-with-cystic-fibrosis-a-systematic-review-and-meta-analysis
#22
Sana Arshid, Saad Ehsan Ullah, Junaid Imran, Meeran Asher Syed, Aakash Choradia, Nicole Gousy, Sukhman Boparai, Mudassir Shoaib, Bidhan Bikram Shah, Aadarsh Netha
BACKGROUND: Inhaled hypertonic saline (HS) is an effective mucolytic agent in patients with cystic fibrosis (CF). However, adverse events can impair the clinical utility of hypertonic saline (HS) in this patient population. In this study, we aimed to investigate the effectiveness of hyaluronic acid (HA) in reducing these adverse events. METHODS: A literature search was conducted across three electronic databases (Medline, Cochrane Central, and EMBASE) from inception through February 2023...
2023: Canadian Journal of Respiratory Therapy: CJRT
https://read.qxmd.com/read/37915631/comparison-of-nebulised-3-hypertonic-saline-with-ipratropium-bromide-in-treatment-of-children-with-bronchiolitis-a-randomized-control-trial
#23
JOURNAL ARTICLE
Hina Naveed, Shahzad Munir, Kokab Rafiq, Asma Tayyab, Nauman Naseer, Irshad Hussain, Micheal Halim, Hassan Mumtaz
INTRODUCTION: Several drugs are in use for nebulization in children with acute bronchiolitis and no study has yet been conducted to compare the treatment outcome of nebulized ipratropium bromide and nebulized 3% hypertonic saline in Pakistan. OBJECTIVE: The objective was to compare the treatment outcome of nebulized hypertonic saline and ipratropium bromide in children with acute bronchiolitis. SETTING: Department of Pediatrics. STUDY DURATION: October 2019 to March 2020...
November 2023: Annals of Medicine and Surgery
https://read.qxmd.com/read/37773464/the-impact-of-hypertonic-saline-on-damage-control-laparotomy-after-penetrating-abdominal-trauma
#24
JOURNAL ARTICLE
Lee Schmidt, Lillian Kang, Taylor Hudson, Patricia Martinez Quinones, Kathleen Hirsch, Kristen DiFiore, Krista Haines, Lewis J Kaplan, Joseph S Fernandez-Moure
PURPOSE: The inability to achieve primary fascial closure (PFC) after emergency laparotomy increases the rates of adverse outcomes including fistula formation, incisional hernia, and intraabdominal infection. Hypertonic saline (HTS) infusion improves early PFC rates and decreases time to PFC in patients undergoing damage control laparotomy (DCL) after injury. We hypothesized that in patients undergoing DCL after penetrating abdominal injury, HTS infusion would decrease the time to fascial closure as well as the volume of crystalloid required for resuscitation without inducing clinically relevant acute kidney injury (AKI) or electrolyte derangements...
September 29, 2023: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
https://read.qxmd.com/read/37767724/hypertonic-solution-as-an-optimal-submucosal-injection-solution-for-endoscopic-resection-of-gastrointestinal-mucosal-lesions-systematic-review-and-network-meta-analysis
#25
REVIEW
Li Gao, Jiawei Bai, Kai Liu, Lulu Wang, Shaohua Zhu, Xin Zhao, Ying Han, Zhiguo Liu
OBJECTIVES: Based on different physicochemical properties, common submucosal injection solutions could be classified into three categories: normal saline solution (NS), hypertonic solution (HS), and viscous solution (VS). We compared the efficacy and safety of various categories of solutions in this network meta-analysis of randomized controlled trials (RCTs) to identify the optimal submucosal injection fluid. METHODS: PubMed, Embase, Web of Science, and the Cochrane Library were searched for RCTs that compared the efficacy and safety of NS, HS, and VS during endoscopic resection for gastrointestinal (GI) mucosal lesions...
September 28, 2023: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://read.qxmd.com/read/37763015/efficacy-of-breathox-%C3%A2-device-inhalation-on-acute-symptoms-associated-with-covid-19-breath-study-a-randomized-pilot-clinical-trial
#26
JOURNAL ARTICLE
Suzana Tanni, Fernando Wehrmeister, Robson Prudente, Felipe Damatto, Carlos Breda Neto, Leiliane Oliveira, Luana Pagan, Mariana Gatto, Letícia Vieira, Liana Coelho, Diane Rezende, Luiz Machado, Gustavo Mota, Marina Gaiato, Felipe Santaella, Elisângela Campos, Estefânia Franco, Matheus Callegari, Marina Politi Okoshi, Ulla Weinreich
(1) Background: A high concentration of sodium chloride on in vitro cell culture leads to reduced SARS-CoV-2 replication. Therefore, our aim was to evaluate the effects of inhaling hypertonic NaCl particles (BREATHOX® ) on the duration of COVID-19-induced acute symptoms. (2) Methods: A prospective, open label, randomized, standard of care-controlled group (SOC) pilot trial compared inhaled oral and nasal administered BREATHOX® (2.0 mg NaCl, particles size between 1-10 μm), with five or ten inhalations per day for ten days...
September 20, 2023: Journal of Clinical Medicine
https://read.qxmd.com/read/37751175/astragaloside-iv-inhibited-podocyte-pyroptosis-in-diabetic-kidney-disease-by-regulating-sirt6-hif-1%C3%AE-axis
#27
JOURNAL ARTICLE
Mingyu Zhang, Wenyuan Liu, Yuxiang Liu, Ziyuan Zhang, Yaling Hu, Dalin Sun, Sufen Li, Jingai Fang
To investigate the effect of astragaloside IV (AS) on podocytes pyroptosis in diabetic kidney disease (DKD). Forty male Sprague-Dawley rats were randomly divided into normal group ( n  = 10) and model group ( n  = 30). Rats in model group were intraperitoneally injected streptozotocin (60 mg/kg) for 3 days to induce DKD. Then rats were divided into DKD group, AS group, and UBCS group. The AS group was given 40 mg/kg/d of AS by gavage, and UBCS group was given 50 mg/kg/d of UBCS039 by gavage, and normal group and DKD group were given the same amount saline for 8 weeks, once a day...
October 2023: DNA and Cell Biology
https://read.qxmd.com/read/37722756/involvement-of-the-spinal-%C3%AE-aminobutyric-acid-receptor-in-the-analgesic-effects-of-intrathecally-injected-hypertonic-saline-in-spinal-nerve-ligated-rats
#28
JOURNAL ARTICLE
Myong-Hwan Karm, Hyun-Jung Kwon, Euiyong Shin, Honggyoon Bae, Young Ki Kim, Seong-Soo Choi
BACKGROUND: : Hypertonic saline is used for treating chronic pain; however, clinical studies that aid in optimizing therapeutic protocols are lacking. We aimed to determine the concentration of intrathecally injected hypertonic saline at which the effect reaches its peak as well as the underlying γ-aminobutyric acid (GABA) receptor-related antinociceptive mechanism. METHODS: : Spinal nerve ligation (SNL; left L5 and L6) was performed to induce neuropathic pain in rats weighing 250-300 g...
October 1, 2023: Korean Journal of Pain
https://read.qxmd.com/read/37719001/trans-catheter-mitral-valve-in-valve-replacement-in-a-patient-on-venoarterial-extracorporeal-membrane-oxygenation-a-case-report
#29
Jassimran Singh Bainiwal, Jeremy-Ann Ham, Olcay Aksoy
BACKGROUND: Bioprosthetic mitral valves on average have a median durability between 8 and 10 years. After the failure of a bioprosthetic valve, surgical replacement is often indicated. However, the options for those patients at high or prohibitive surgical risks are limited. Here, we describe a case of a successful trans-catheter mitral valve-in-valve (TMViV) replacement on venoarterial extracorporeal membrane oxygenation (VA-ECMO). CASE SUMMARY: We describe a case of a 39-year-old female with a history notable for systemic lupus erythematosus, severe pulmonary arterial hypertension (now mixed pre and post) thought to be secondary to prior substance use, and infective endocarditis complicated by severe mitral stenosis status post-bioprosthetic mitral valve replacement who presented with symptoms of acute hypoxic respiratory failure secondary to severe bioprosthetic mitral valve stenosis...
September 2023: European Heart Journal. Case Reports
https://read.qxmd.com/read/37695599/impact-of-octreotide-on-sodium-level-in-cirrhotic-inpatients-with-hyponatremia-a-retrospective-study
#30
JOURNAL ARTICLE
Bahaaeldeen Ismail, Richard Charnigo, Syed Mohammad Ali, Baker Alkhairi, Karim Benrajab, Harjinder Singh, Fernando J Castro
OBJECTIVE: Octreotide could increase serum sodium in cirrhotics with hyponatremia by counteracting splanchnic vasodilation. Current supporting data is limited to case reports and series. The aim of the study is to assess the effect of octreotide on serum sodium in cirrhotic inpatients with hyponatremia compared with controls. METHODS: This is a retrospective study including adult inpatients with cirrhosis, admitted for ≥5 days with Na <133 at baseline...
September 11, 2023: European Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/37660715/safety-and-efficacy-of-the-epithelial-sodium-channel-blocker-idrevloride-in-people-with-primary-ciliary-dyskinesia-clean-pcd-a-multinational-phase-2-randomised-double-blind-placebo-controlled-crossover-trial
#31
JOURNAL ARTICLE
Felix C Ringshausen, Adam J Shapiro, Kim G Nielsen, Henryk Mazurek, Massimo Pifferi, Karl H Donn, Menno M van der Eerden, Michael R Loebinger, Maimoona A Zariwala, Margaret W Leigh, Michael R Knowles, Thomas W Ferkol
BACKGROUND: Mucociliary clearance is dysfunctional in people with primary ciliary dyskinesia, resulting in the accumulation of dehydrated mucus in the airways that is difficult to clear. We undertook a study to assess the benefit on lung function of treatment with a nebulised epithelial sodium channel (ENaC) blocker, idrevloride, with or without hypertonic saline, in people with primary ciliary dyskinesia. METHODS: The CLEAN-PCD trial was a phase 2, randomised, double-blind, placebo-controlled crossover trial conducted at 32 tertiary adult and paediatric care centres and university hospitals in Canada, Denmark, Germany, Italy, the Netherlands, Poland, the UK, and the USA...
August 31, 2023: Lancet Respiratory Medicine
https://read.qxmd.com/read/37607514/arginine-stimulated-copeptin-based-diagnosis-of-central-diabetes-insipidus-in-children-and-adolescents
#32
JOURNAL ARTICLE
Sebastian Gippert, Maik Brune, Ruth L Dirksen, Daniela Choukair, Markus Bettendorf
INTRODUCTION: Diagnosis of central diabetes insipidus (CDI) remains challenging. Water deprivation testing and hypertonic saline infusion, as established diagnostic tests, are mentally and physically demanding for patients. Arginine-stimulated copeptin has been shown as a putative parameter for the differential diagnosis of CDI in adults. METHODS: In this single-centre retrospective study, we identified paediatric patients with suspected pituitary disorders who underwent standard arginine-testing...
August 22, 2023: Hormone Research in Pædiatrics
https://read.qxmd.com/read/37573430/hypertonic-saline-induces-inflammation-in-human-macrophages-through-the-nlrp1-inflammasome
#33
JOURNAL ARTICLE
Francesca Sposito, Sarah Northey, Amandine Charras, Paul S McNamara, Christian M Hedrich
Nebulized hypertonic saline (3-7%) is commonly used to increase mucociliary clearance in patients with chronic airway disease and/or virus infections. However, altered salt concentrations may contribute to inflammatory responses. The aim of this study was to investigate whether 500 mM NaCl (3%) triggers inflammation in human macrophages and identify the molecular mechanisms involved. NaCl-induced pyroptosis, IL-1β, IL-18 and ASC speck release were measured in primary human monocyte-derived macrophages...
October 2023: Genes and Immunity
https://read.qxmd.com/read/37564831/the-kinetics-of-isotonic-and-hypertonic-resuscitation-fluids-is-dependent-on-the-sizes-of-the-body-fluid-volumes
#34
JOURNAL ARTICLE
Robert G Hahn
BACKGROUND AND AIMS: The extracellular and intracellular fluid volumes (ECV and ICV) vary not only with age, gender, and body weight but also with the habitual intake of water. The present study examines whether the baseline variations in the ECV and ICV change the distribution and elimination of subsequently given infusion fluids. MATERIAL AND METHODS: Twenty healthy male volunteers underwent 50 infusion experiments with crystalloid fluid for which the fluid volume kinetics was calculated based on frequent measurements of the hemodilution using mixed-effects modeling software...
2023: Journal of Anaesthesiology, Clinical Pharmacology
https://read.qxmd.com/read/37534416/management-practices-for-standard-risk-and-high-risk-patients-with-bronchiolitis
#35
JOURNAL ARTICLE
Derek Spindler, Kimberly K Monroe, Mayya Malakh, Harlan McCaffery, Rebekah Shaw, Nora Biary, Katrina Foo, Kathryn Levy, Roselle Vittorino, Pooja Desai, John Schmidt, D'Anna Saul, Maria Skoczylas, Y Katharine Chang, Rachel Osborn, Emily Jacobson
OBJECTIVE: Management guidelines for bronchiolitis advocate for supportive care and exclude those with high-risk conditions. We aim to describe and compare the management of standard-risk and high-risk patients with bronchiolitis. METHODS: This retrospective study examined patients <2 years of age admitted to the general pediatric ward with an International Classification of Diseases, 10th Revision discharge diagnosis code of bronchiolitis or viral syndrome with evidence of lower respiratory tract involvement...
September 1, 2023: Hospital Pediatrics
https://read.qxmd.com/read/37521749/mega-scale-desalination-efficacy-reverse-osmosis-electrodialysis-membrane-distillation-med-msf-during-covid-19-evidence-from-salinity-pretreatment-methods-temperature-of-operation
#36
JOURNAL ARTICLE
Seyed Masoud Parsa
The unprecedented situation of the COVID-19 pandemic heavily polluted water bodies whereas the presence of SARS-CoV-2, even in treated wastewater in every corner of the world is reported. The main aim of the present study is to show the effectiveness and feasibility of some well-known desalination technologies which are reverse osmosis (RO), Electrodialysis (ED), Membrane Distillation (MD), multi effect distillation (MED), and multi stage flashing (MSF) during the COVID-19 pandemic. Systems' effectiveness against the novel coronavirus based on three parameters of nasopharynx/nasal saline-irrigation, temperature of operation and pretreatment methods are evaluated...
February 2023: J Hazard Mater Adv
https://read.qxmd.com/read/37511706/a-hypertonic-seawater-nasal-irrigation-solution-containing-algal-and-herbal-natural-ingredients-reduces-viral-load-and-sars-cov-2-detection-time-in-the-nasal-cavity
#37
JOURNAL ARTICLE
Ioannis Pantazopoulos, Athanasios Chalkias, Angeliki Miziou, Michalis Spanos, Efrosyni Gerovasileiou, Erasmia Rouka, Konstantinos Gourgoulianis
Nasal irrigation is thought to decrease the viral load present in the nasal cavity. Our aim was to assess the effect of a hypertonic seawater solution [with algal and herbal natural ingredients (Sinomarin® )] on the viral load of nasopharynx in patients hospitalized with severe COVID-19 pneumonia. We conducted a prospective, randomized, controlled trial from June 2022 to December 2022. We allocated 56 patients with COVID-19 pneumonia into two groups (28 in each group)-the hypertonic seawater group [nasal irrigations with a hypertonic seawater solution (Sinomarin® ) every 4 h for 16 h per day, for two consecutive days] and the control group (no nasal irrigations)...
July 3, 2023: Journal of Personalized Medicine
https://read.qxmd.com/read/37503600/the-first-definition-of-pulmonary-component-of-hypereosinophilic-syndrome-bronchial-casts
#38
JOURNAL ARTICLE
Zeynep Reyhan Onay, Yetkin Ayhan, Sinem Can Oksay, Deniz Mavi, Gülay Bilgin, Aysenur Toksoz Yıldırım, Aylin Canbolat Ayhan, Saniye Girit
Hypereosinophilic syndrome is a heterogeneous disease characterized by eosinophilic tissue inflammation and eosinophilia. Pulmonary involvement could be seen in up to 55% among children with hypereosinophilic syndrome. A 3-year-old boy with chronic hypereosinophilia and respiratory complaints was diagnosed with idiopathic hypereosinophilic syndrome. Atelectasis was detected in the radiological evaluation, and bronchial casts with eosinophilic structures were removed by bronchoscopy. Steroid, inhaled hypertonic saline, inhaled bronchodilator, inhaled corticosteroid, and leukotriene receptor antagonist were used for 1 year in the management of hypereosinophilic syndrome, and related eosinophilic casts and repetitive bronchoscopies were administered for removal of the casts...
January 2023: Thorac Res Pract
https://read.qxmd.com/read/37448896/a-case-of-flecainide-induced-hyponatremia
#39
Alexandra Ntemka, Antigoni Martika, Kalliopi Pozoukidou, Sofia Spaia
The complex classification for the diagnosis and treatment illustrates that hyponatremia is a very heterogeneous disorder. However, data on hyponatremia induced by flecainide, an often-prescribed antiarrhythmic agent, are scarce in the literature. A 78-year-old man with a recent history of recurrent hyponatremia and symptomatic paroxysmal atrial fibrillation presented with the complaints of dizziness and fatigue. During his repeated hospital admissions, the patient was treated with hypertonic saline, which temporarily improved serum sodium levels, but hyponatremia recurred without sustained clinical improvement...
2023: Indian Journal of Nephrology
https://read.qxmd.com/read/37403632/variation-in-inhaled-medication-use-for-infants-with-congenital-heart-disease-and-bronchiolitis
#40
JOURNAL ARTICLE
Namrata Ahuja, Troy Richardson, Patrick Brady, Byron A Foster, Justin Godown, Elise Lu, Nicolas Madsen, Samir S Shah, Tamara Wagner, Susan Wu, Christopher Russell
BACKGROUND AND OBJECTIVES: Current viral bronchiolitis guidelines exclude infants with congenital heart disease (CHD). Variations in the use of common therapeutics in this population and their associations with clinical outcomes are unknown. Our objective was to evaluate variations in (1) the use of β-2-agonists and hypertonic saline across hospitals among infants with CHD hospitalized with bronchiolitis, and (2) hospital-level associations between medication use and outcomes. METHODS: We performed a multicenter retrospective cohort study using administrative data from 52 hospitals in the Pediatric Health Information System...
July 5, 2023: Hospital Pediatrics
keyword
keyword
107710
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.