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3% hypertonic saline

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https://www.readbyqxmd.com/read/28072802/efficacy-of-adjuvant-10-hypertonic-saline-in-transforaminal-epidural-steroid-injection-a-retrospective-analysis
#1
Eun Young Joo, Won Uk Koh, Seong-Soo Choi, Jae-Hyung Choi, Ho-Soo Ahn, Hye Joo Yun, Jin-Woo Shin
BACKGROUND: Chronic lower back pain with or without radiculopathy represents an important medical, social, and economic problem. Many treatment modalities and techniques, including surgery and epidural administration of steroids, have been used to manage this pain. Hypertonic saline, which has been used as an adjunct to percutaneous epidural adhesiolysis, can also be injected via a transforaminal approach in expectation of longer-lasting effects. OBJECTIVES: This study aimed to determine the effect of adding hypertonic saline to conventional transforaminal epidural steroid injections (TFEI) to provide pain relief for chronic radiculopathy patients...
January 2017: Pain Physician
https://www.readbyqxmd.com/read/28072729/hypertonic-saline-protects-brain-endothelial-cells-against-hypoxia-correlated-to-the-levels-of-estimated-glomerular-filtration-rate-and-interleukin-1%C3%AE
#2
Sheng-Long Chen, Yi-Yu Deng, Qiao-Sheng Wang, Yong-Li Han, Wen-Qiang Jiang, Ming Fang, Bei Hu, Zhi-Xin Wu, Lin-Qiang Huang, Hong-Ke Zeng
OBJECTIVE: The aim of this study was to verify the protective effect of hypertonic saline (HS) on brain endothelial cells under hypoxic conditions and the relevant underlying mechanism. METHODS: bEnd.3 cells were treated with oxygen-glucose deprivation (OGD)-induced injury. To measure HS performance, cell viability was determined using the 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium salt assay, and cell apoptosis was assessed by flow cytometry and Terminal deoxynucleotidyl transferase UTP nick-end labeling staining...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28059631/acute-necrotizing-encephalopathy-causing-human-bocavirus
#3
Ayse Betul Ergul, Umit Altug, Kursad Aydin, Ahmet Sami Guven, Yasemin Altuner Torun
Acute necrotizing encephalopathy is characterized by multiple, symmetrical lesions involving the thalamus, brainstem, cerebellum, and white matter and develops secondarily to viral infections. Influenza viruses are the most common etiological agents. Here, we present the first case of acute necrotizing encephalopathy to develop secondarily to human bocavirus. A 3-year-old girl presented with fever and altered mental status. She had had a fever, cough, and rhinorrhea for five days. The patient was admitted to the intensive care unit with an initial diagnosis of encephalitis when vomiting, convulsions, and loss of consciousness developed...
January 1, 2017: Neuroradiology Journal
https://www.readbyqxmd.com/read/28042364/predictors-of-acute-kidney-injury-in-neurocritical-care-patients-receiving-continuous-hypertonic-saline
#4
Michael J Erdman, Heidi Riha, Lauren Bode, Jason J Chang, G Morgan Jones
BACKGROUND AND PURPOSE: Continuous intravenous 3% hypertonic saline (HTS) infusions are commonly used for the management of cerebral edema following severe neurologic injuries. Despite widespread use, data regarding the incidence and predictors of nephrotoxicity are lacking. The purpose of this study was to describe the incidence and identify predictors of acute kidney injury (AKI) in neurocritical care patients administered continuous infusion HTS. METHODS: This was an institutional review board-approved, multicenter, retrospective cohort study of patients receiving HTS infusions at 2 academic medical centers...
January 2017: Neurohospitalist
https://www.readbyqxmd.com/read/27941973/immune-inflammatory-and-metabolic-effects-of-high-dose-furosemide-plus-hypertonic-saline-solution-hss-treatment-in-cirrhotic-subjects-with-refractory-ascites
#5
Antonino Tuttolomondo, Domenico Di Raimondo, Chiara Bellia, Giuseppe Clemente, Rosaria Pecoraro, Carlo Maida, Irene Simonetta, Valerio Vassallo, Danilo Di Bona, Eliana Gulotta, Marcello Ciaccio, Antonio Pinto
INTRODUCTION: Patients with chronic liver diseases are usually thin as a result of hypermetabolism and malnutrition expressed by reduced levels of leptin and impairment of other adyponectins such as visfatin. AIMS: We evaluated the metabolic and inflammatory effects of intravenous high-dose furosemide plus hypertonic saline solutions (HSS) compared with repeated paracentesis and a standard oral diuretic schedule, in patients with cirrhosis and refractory ascites...
2016: PloS One
https://www.readbyqxmd.com/read/27940101/normal-saline-solution-versus-other-viscous-solutions-for-submucosal-injection-during-endoscopic-mucosal-resection-a-systematic-review-and-meta-analysis
#6
REVIEW
Harathi Yandrapu, Madhav Desai, Sameer Siddique, Prashanth Vennalaganti, Sreekar Vennalaganti, Sravanthi Parasa, Tarun Rai, Vijay Kanakadandi, Ajay Bansal, Mohammad Titi, Alessandro Repici, Matthew L Bechtold, Prateek Sharma, Abhishek Choudhary
BACKGROUND: Endoscopic mucosal resection (EMR) is being increasingly practiced for the removal of large colorectal polyps. A variety of solutions such as normal saline solution (NS) and other viscous and hypertonic solutions (VS) have been used as submucosal injections for EMR. AIM: To conduct a systematic review and meta-analysis comparing the efficacy and adverse events of EMR performed using NS versus VS. METHODS: Two independent reviewers conducted a search of all data bases for human, randomized controlled trials that compared NS with VS for EMR of colorectal polyps...
December 8, 2016: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/27779578/does-small-volume-resuscitation-with-crystalloids-or-colloids-influence-hemostasis-and-survival-of-rabbits-subjected-to-lethal-uncontrolled-hemorrhage
#7
Bijan Shams Kheirabadi, Nahir Miranda, Irasema B Terrazas, Mary D Gonzales, Rose C Grimm, Michael A Dubick
BACKGROUND: Prehospital, small-volume resuscitation of combat casualties with a synthetic colloid (6% hydroxyethyl starch [HES] 670/0.75) has been recommended when blood or blood components are unavailable. We studied hemostatic effects of a newer synthetic colloid (6% HES, 130/0.4) compared with either a natural colloid (albumin) or to crystalloids in an uncontrolled hemorrhage model. METHODS: Spontaneously breathing New Zealand white rabbits (3.4 ± 0.1 kg) were anesthetized, instrumented, and subjected to a splenic injury with uncontrolled bleeding...
January 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/27777397/evaluation-of-the-maintained-effect-of-3-hypertonic-saline-solution-in-an-animal-model-of-intracranial-hypertension
#8
Leonardo M Sousa, Almir F de Andrade, Alessandro R Belon, Matheus S Soares, Robson Luis Amorim, Jose Pinhata Otochi, Manoel J Teixeira, Wellingson S Paiva
BACKGROUND Current clinical treatment methods for refractory intracranial hypertension include elevation of the decubitus, ventilation adjustment, and use of hypertonic solutions such as hypertonic saline and mannitol solutions. Previous studies have shown that hypertonic solutions are particularly effective. Although several concentrations of saline solution have been proposed, a 3% solution is the most widely used. The aim of this study was to evaluate the maintained efficacy of a 3% hypertonic saline solution in an experimental model of intracranial hypertension...
October 25, 2016: Medical Science Monitor Basic Research
https://www.readbyqxmd.com/read/27774418/nephroprotective-effect-of-ethanolic-extract-of-azima-tetracantha-root-in-glycerol-induced-acute-renal-failure-in-wistar-albino-rats
#9
Venugopala Rao Konda, Ruckmani Arunachalam, Madhavi Eerike, Ramesh Rao K, Arun Kumar Radhakrishnan, Lakshmipathy Prabhu Raghuraman, Vinayak Meti, Sobita Devi
The gravity of the impact of renal failure on human health is well known and as there is no specific pharmacotherapy for renal failure, the current study was undertaken to evaluate the effect of root extract of Azima tetracantha, an ancient medicinal plant used in Siddha and Ayurvedhic systems of medicine. The experiment was done in glycerol-induced acute renal failure in Wistar albino rats. Thirty rats were divided into five groups. Group 1 was given normal saline (10 ml/kg) per oral, group 2 with single dose of hypertonic glycerol (8 ml/kg) by intramuscular injection into the hind limbs, group 3 with glycerol and ethanolic extract of A...
October 2016: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/27746581/diffusion-sensitive-optical-coherence-tomography-for-real-time-monitoring-of-mucus-thinning-treatments
#10
Richard L Blackmon, Silvia M Kreda, Patrick R Sears, Lawrence E Ostrowski, David B Hill, Brian S Chapman, Joseph B Tracy, Amy L Oldenburg
Mucus hydration (wt%) has become an increasingly useful metric in real-time assessment of respiratory health in diseases like cystic fibrosis and COPD, with higher wt% indicative of diseased states. However, available in vivo rheological techniques are lacking. Gold nanorods (GNRs) are attractive biological probes whose diffusion through tissue is sensitive to the correlation length of comprising biopolymers. Through employment of dynamic light scattering theory on OCT signals from GNRs, we find that weakly-constrained GNR diffusion predictably decreases with increasing wt% (more disease-like) mucus...
2016: Proceedings of SPIE
https://www.readbyqxmd.com/read/27739087/effect-of-experimental-anterior-temporalis-muscle-pain-on-jaw-movements
#11
M Amhamed, T Whittle, T Maulina, J Gal, R Akhter, G M Murray
To test the hypotheses that experimental noxious stimulation of the anterior temporalis muscle results in significant decreases in jaw movement amplitude and velocity, and there are significant correlations between scores of mood or pain-related cognitions and amplitude and velocity. The jaw movements of 14 asymptomatic participants were recorded during standardised open/close jaw movements and free and standardised chewing tasks. Tonic infusion of hypertonic saline into the right anterior temporalis muscle maintained pain intensity between 40 and 60 mm on a 100-mm visual analogue scale...
December 2016: Journal of Oral Rehabilitation
https://www.readbyqxmd.com/read/27716387/extreme-hypernatremia-as-a-probable-cause-of-fatal-arrhythmia-a-case-report
#12
Maulee Hiromi Arambewela, Noel P Somasundaram, Chaminda Garusinghe
BACKGROUND: Hypernatremia is a frequent occurrence among hospitalized patients. Severe hypernatremia is associated with mortality rates of over 60 %. Extreme hypernatremia, defined as sodium levels >190 mmol/l, is a rare occurrence. The literature on electrocardiographic changes occurring with this degree of hypernatremia is extremely scarce. We report the case of an 11-year-old Sri Lankan girl who presented with sodium levels of 226 mmol/l following infusion with 3 % hypertonic saline who developed diffuse QT prolongation leading to fatal ventricular tachycardia...
October 1, 2016: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/27636207/a-case-of-3-4-dimethoxyamphetamine-3-4-dma-and-3-4-methylenedioxymethamphetamine-mdma-toxicity-with-possible-metabolic-interaction
#13
Michael A Darracq, Stephen L Thornton, Alicia B Minns, Roy R Gerona
: We present a case of "ecstasy" ingestion revealing 3,4-methylenedioxymethamphetamine (MDMA) and 3,4-dimethoxyamphetamine (3,4-DMA) and absence of cytochrome P450 (CYP)-2D6 MDMA metabolites. CASE REPORT: A 19-year-old presented following a seizure. Initial vital signs were normal. Laboratories were normal with the exception of sodium 127 mEq/L and urine drugs of abuse screen positive for amphetamines. Twelve hours later, serum sodium was 114 mEq/L and a second seizure occurred...
November 2016: Journal of Psychoactive Drugs
https://www.readbyqxmd.com/read/27624002/allergy-specific-phenome-wide-association-study-for-immunogenes-in-turkish-children
#14
Sefayet Karaca, Ersoy Civelek, Mehmet Karaca, Umit M Sahiner, Riza K Ozgul, Can N Kocabas, Renato Polimanti, Bülent E Sekerel
To dissect the role of immunogenetics in allergy and asthma, we performed a phenome-wide association study in 974 Turkish children selected from a cross-sectional study conducted using ISAAC (International Study of Asthma and Allergies in Children) Phase II tools. We investigated 9 loci involved in different immune functions (ADAM33, ADRB2, CD14, IL13, IL4, IL4R, MS4A2, SERPINE1, and TNF) with respect to 116 traits assessed through blood tests, hypertonic saline challenge tests, questionnaires, and skin prick tests...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27568371/hyperosmolar-therapy-in-pediatric-traumatic-brain-injury-a-retrospective-study
#15
Nadia Roumeliotis, Christian Dong, Géraldine Pettersen, Louis Crevier, Guillaume Emeriaud
OBJECTIVES: The objectives of the study are to describe the use of hyperosmolar therapy in pediatric traumatic brain injury (TBI) and examine its effect on intracranial pressure (ICP) and cerebral perfusion pressure (CPP). DESIGN: A retrospective review of patients with severe TBI admitted to the pediatric intensive care unit (PICU) was conducted. Inclusion criteria were ICP monitoring and administration of a hyperosmolar agent (20 % mannitol or 3 % hypertonic saline) within 48 h of PICU admission; for which dose and timing were recorded...
December 2016: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/27558187/severe-hyponatraemia-associated-with-pre-eclampsia
#16
Breffini Anglim, Kirk Levins, Neidin Bussmann, Mendinaro Imcha
Pre-eclampsia is a multisystem disorder with incidence rates ranging from 2% to 5%. Hyponatraemia is a rare complication of pre-eclampsia. A 41-year-old, para 0+1 in vitro fertilisation monochorionic diamniotic triplet pregnancy woman presented at 25 weeks with dyspnoea and general malaise. Her antenatal course was complicated by the diagnosis of intrauterine growth restriction in triplet one at 27 weeks of gestation. At 27+3 weeks gestation, she was diagnosed as having pre-eclampsia. Subsequent biochemical analysis demonstrated hyponatraemia with serum sodium falling steadily to 117 mmol/L over the next 19 days...
August 24, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27543734/a-randomized-controlled-study-comparing-the-efficacy-of-positive-pressure-nasal-saline-irrigation-device-versus-syringe-use-in-children-with-acute-rhinosinusitis
#17
Araya Satdhabudha, Kusumawadee Utispan, Paopaga Monthanapisut, Orapan Poachanukoon
OBJECTIVE: To evaluate the efficacy of positive pressure nasal irrigation and the incidence of bacterial colonization found in the irrigation device utilized for nasal saline irrigation in children with acute sinusitis. METHODS: We performed a randomized, prospective, controlled study of 80 children with acute sinusitis, aged 3-15 years. Each participant was randomized into one of two groups, one treated with a squeezable bottle and the other group treated with a syringe...
August 16, 2016: Asian Pacific Journal of Allergy and Immunology
https://www.readbyqxmd.com/read/27513397/comparison-between-the-use-of-saline-and-seawater-for-nasal-obstruction-in-children-under-2-years-of-age-with-acute-upper-respiratory-infection
#18
Tülin Köksal, Mehmet Nevzat Çizmeci, Davut Bozkaya, Mehmet Kenan Kanburoğlu, Şanlıay Şahin, Tuğba Taş, Çiğdem Nükhet Yüksel, Mustafa Mansur Tatli
BACKGROUND/AIM: The effectiveness of isotonic and hypertonic saline solutions used to open the nasal passage and improve clinical symptoms was compared in children under 2 years of age admitted with the common cold. MATERIALS AND METHODS: The study was performed as a randomized, prospective, and double-blind study. The study included 109 children. The children using saline (0.9%) and seawater (2.3%) as nasal drops (the patient group) and the control group (in which nasal drops were not administered) were compared...
2016: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/27492738/impact-of-the-implementation-of-an-evidence-based-guideline-on-diagnostic-testing-management-and-clinical-outcomes-for-infants-with-bronchiolitis
#19
Ricardo Henao-Villada, Monica P Sossa-Briceño, Carlos E Rodríguez-Martínez
BACKGROUND: Although bronchiolitis poses a significant health problem in low- and middle-income countries (LMICs), to the best of our knowledge, to date it has not been determined whether evidence-based bronchiolitis clinical practice guidelines (CPGs) complemented by standardized educational strategies reduce the use of unnecessary diagnostic tests and medications and improve clinically important outcomes in LMICs. METHODS: In an uncontrolled before and after study, we assessed the impact of the implementation of an evidence-based bronchiolitis CPG on physician behavior and the care of infants with bronchiolitis by comparing pre-guideline (March to August 2014) and post-guideline (March to August 2015) use of diagnostic tests and medications through an electronic medical record review in a children's hospital in Bogota, Colombia...
October 2016: Therapeutic Advances in Respiratory Disease
https://www.readbyqxmd.com/read/27403389/comparing-the-efficacy-of-7-3-and-0-9-saline-in-moderate-to-severe-bronchiolitis-in-infants
#20
Seçil Köse, Ahmet Şehriyaroğlu, Feyza Esen, Ahmet Özdemir, Zehra Kardaş, Umut Altuğ, Esef Karakuş, Alper Özcan, Ali Fatih Kısaarslan, Ferhan Elmalı, Yasemin Altuner Torun, Mehmet Köse
BACKGROUND: There is no standard treatment option in acute bronchiolitis. 3-7% hypertonic saline (HS) seems to be the effective treatment choice for reducing the hospitalization day. AIMS: To compare the effect of nebulized 7% HS/salbutamol and 3% HS/salbutamol to 0.9% saline/salbutamol. The primary outcome measure was the effect of study drugs on the length of hospital stay (LOS). Secondary outcome measures were safety and efficacy in reducing the clinical severity score (CSS) at the 24 hours of the study...
March 2016: Balkan Medical Journal
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