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3% hypertonic saline

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https://www.readbyqxmd.com/read/29437746/from-renal-salt-wasting-to-siadh
#1
Tzy Harn Chua, Matin Ly, Senthil Thillainadesan, Katie Wynne
Hyponatraemia is common following major head injury and is associated with significant morbidity and mortality. A 20-year-old man presented with reduced consciousness after head trauma and was found to have a fractured skull base with bilateral frontal contusions. On day 3 of his admission, he developed hyponatraemia with raised urine sodium and osmolality, despite receiving dexamethasone and intravenous fluid therapy. His hyponatraemia worsened after the treatment with fluid restriction and oral salt. He was in negative fluid balance suggesting possible renal salt wasting...
February 5, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29430670/the-effect-of-3-resuscitative-fluid-therapies-on-hemostasis-as-measured-by-rotational-thromboelastometry-in-dogs
#2
Sunita Seshia, M Casey Gaunt, Beverly A Kidney, Marion L Jackson
BACKGROUND: Evidence suggests that administration of intravenous fluids impairs hemostasis. Thromboelastometry (TEM) may provide a more sensitive measure of the fluid effects on hemostasis than traditional coagulation tests. OBJECTIVE: The study aim was to determine if resuscitative fluid therapy affects hemostasis, as measured by TEM. MATERIALS AND METHODS: Using a randomized crossover design, 6 healthy dogs were administered intravenous colloid, crystalloid, and hypertonic saline at therapeutic doses...
February 11, 2018: Veterinary Clinical Pathology
https://www.readbyqxmd.com/read/29391896/perfused-hypertonic-saline-augmented-needle-enlarges-ablation-zones-in-ex-vivo-porcine-livers
#3
Caoye Wang, Qi Wang, Dachuan Zhang, Zhongming He, Wenhua Chen
There is a great clinical requirement to improve radiofrequency ablation (RFA) efficacy and create larger coagulation necrotic areas. The aim of the present study was to assess the ability of a hypertonic-saline (HS)-enhanced multipolar RFA technique using a perfused electrode to increase RF-created coagulation necrosis, and to compare that technique with natural saline-augmented needle and conventional multipolar RFA. A total of 18 ablations were performed in explanted porcine livers. A total of 6 thermal ablation zones were created in each of 3 groups treated with the conventional multipolar mode, the multipolar mode with 0...
January 2018: Oncology Letters
https://www.readbyqxmd.com/read/29369834/oral-hypertonic-saline-is-effective-in-reversing-acute-mild-to-moderate-symptomatic-exercise-associated-hyponatremia
#4
Eileen Bridges, Tawfeeq Altherwi, José A Correa, Tamara Hew-Butler
OBJECTIVES: To determine whether oral administration of 3% hypertonic saline (HTS) is as efficacious as intravenous (IV) 3% saline in reversing symptoms of mild-to-moderate symptomatic exercise-associated hyponatremia (EAH) in athletes during and after a long-distance triathlon. DESIGN: Noninferiority, open-label, parallel-group, randomized control trial to IV or oral HTS. We used permuted block randomization with sealed envelopes, containing the word either "oral" or "IV...
January 23, 2018: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/29365179/collapse-in-the-heat-from-overhydration-to-the-emergency-room-three-cases-of-exercise-associated-hyponatremia-associated-with-exertional-heat-illness
#5
Robert C Oh, Bryan Malave, Justin D Chaltry
Exertional heat illness and exercise-associated hyponatremia continue to be a problem in military and recreational events. Symptoms of hyponatremia can be mistaken for heat exhaustion or heat stroke. We describe three cases of symptomatic hyponatremia initially contributed to heat illnesses. The first soldier was a 31-yr-old female who "took a knee" at mile 6 of a 12-mile foot march. She had a core temperature of 100.9°F, a serum sodium level of 129 mmol/L, and drank approximately 4.5 quarts of water in 2 h...
January 22, 2018: Military Medicine
https://www.readbyqxmd.com/read/29357474/the-influence-of-acute-elevations-in-plasma-osmolality-and-serum-sodium-on-sympathetic-outflow-and-blood-pressure-responses-to-exercise
#6
Michael S Brian, Evan L Matthews, Joseph Charles Watso, Matthew Charles Babcock, Megan M Wenner, William C Rose, Sean D Stocker, William B Farquhar
Elevated plasma osmolality (pOsm) has been shown to increase resting sympathetic nerve activity in animals and humans. The following study tested the hypothesis that increases in pOsm and serum sodium (sNa+) would exaggerate muscle sympathetic nerve activity (MSNA) and blood pressure (BP) responses to handgrip (HG) exercise and post-exercise ischemia (PEI). BP and MSNA were measured during HG followed by PEI before and after a 23-min hypertonic saline infusion (HSI-3% NaCl). Eighteen participants (age 23{plus minus}1 yrs; BMI 24{plus minus}1 kg·(m2)-1) completed the protocol; pOsm and sNa increased from pre- to post-HSI (285{plus minus}1 to 291{plus minus}1 mOsm·kg H2O-1; 138...
December 13, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/29305272/effect-of-hyperosmolar-therapy-on-outcome-following-spontaneous-intracerebral-hemorrhage-ethnic-racial-variations-of-intracerebral-hemorrhage-erich-study
#7
Manan Shah, Lee Birnbaum, Jennifer Rasmussen, Padmini Sekar, Charles J Moomaw, Jennifer Osborne, Anastasia Vashkevich, Daniel Woo
PURPOSE: We aimed to identify the effect of hyperosmolar therapy (mannitol and hypertonic saline) on outcomes after intracerebral hemorrhage (ICH) in the Ethnic/Racial Variations of Intracerebral Hemorrhage (ERICH) study. METHODS: Comparison of ICH cases treated with hyperosmolar therapy versus untreated cases was performed using a propensity score based on age, initial Glasgow Coma Scale, location of ICH (lobar, deep, brainstem, and cerebellar), log-transformed initial ICH volume, presence of intraventricular hemorrhage, and surgical interventions...
January 3, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29288267/pi3k-akt-pathway-a-role-in-%C3%AE-opioid-receptor-mediated-rgc-neuroprotection
#8
Shahid Husain, Anis Ahmad, Sudha Singh, Carolyn Peterseim, Yasir Abdul, Matthew J Nutaitis
Purpose: This study examines the role of PI3K/Akt pathway in δ-opioid receptor agonist (SNC-121)-induced RGC neuroprotection in a chronic glaucoma rat model. Methods: Injecting hypertonic saline into the limbal veins of Brown Norway rats elevated IOP. Rats were treated either with 1 mg/kg SNC-121 or 3 mg/kg 2-(4-morpholinyl)-8-phenyl-1(4H)-benzopyran-4-one hydrochloride (LY-294002; PI3K/Akt inhibitor) plus SNC-121 once daily for 7 days. Pattern ERGs were recorded in response to contrast reversal of patterned visual stimuli...
December 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29261544/mu-opioid-receptors-in-ganglia-but-not-in-muscle-mediate-peripheral-analgesia-in-rat-muscle-pain
#9
Ana Bagues, María Isabel Martín, Alejandro Higuera-Matas, Jesús Esteban-Hernández, Emilio Ambrosio, Eva María Sánchez-Robles
BACKGROUND: Previous studies have demonstrated the participation of peripheral μ-opioid receptors (MOR) in the antinociceptive effect of systemically administered morphine and loperamide in an orofacial muscle pain model, induced by hypertonic saline, but not in a spinally innervated one, in rats. In this study, we determine whether this peripheral antinociceptive effect is due to the activation of MOR localized in the muscle, ganglia, or both. METHODS: To determine the local antinociceptive effect of morphine and loperamide, 2 models of acute muscle pain (trigeminal and spinal) were used...
December 19, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29244891/the-effects-of-experimental-temporalis-muscle-pain-on-jaw-muscle-electromyographic-activity-during-jaw-movements-and-relationships-with-some-psychological-variables
#10
Tantry Maulina, Magda Amhamed, Terry Whittle, John Gal, Rahena Akhter, Greg M Murray
AIMS: To determine if the effects of experimental temporalis muscle pain on jaw muscle activity vary with the jaw task performed, jaw displacement magnitude, participant being studied, and with psychological measures. METHODS: Jaw movement was tracked, and electromyographic (EMG) activity was recorded from the masseter and anterior temporalis and digastric muscles in 14 asymptomatic participants during standardized opening/closing jaw movement, free chewing, and standardized chewing tasks...
December 15, 2017: Journal of Oral & Facial Pain and Headache
https://www.readbyqxmd.com/read/29235735/homemade-hypertonic-saline-essential-treatment-can-be-available-and-affordable
#11
Nili Elior, Diana Tasher, Elli Somekh, Michal Stein, Orna Schwartz Harari, Avigdor Mandelberg
BACKGROUND: Nebulized hypertonic saline (HS) treatment is unavailable to large populations worldwide. OBJECTIVES: To determine the bacterial contamination and electrolyte concentrations in homemade (HM-HS) vs. pharmacy made (PM-HS). METHODS: We conducted three double-blind consecutive trials: 50 boiled-water homemade 3%-HS (B-HM-HS) bottles and 50 PM-HS. The bottles were cultured after 48 hours. Electrolyte concentrations were measured in 10 bottles (5 per group)...
December 2017: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/29206647/microvascular-permeability-after-an-acute-and-chronic-salt-load-in-healthy-subjects-a-randomized-open-label-crossover-intervention-study
#12
Nienke M G Rorije, Rik H G Olde Engberink, Youssef Chahid, Naomi van Vlies, Jan P van Straalen, Bert-Jan H van den Born, Hein J Verberne, Liffert Vogt
BACKGROUND: Sodium-induced microcirculatory changes, endothelial surface layer alterations in particular, may play an important role in sodium-mediated blood pressure elevation. However, effects of acute and chronic sodium loading on the endothelial surface layer and microcirculation in humans have not been established. The objective of this study was to assess sodium-induced changes in blood pressure and body weight as primary outcomes and also in microvascular permeability, sublingual microcirculatory dimensions, and urinary glycosaminoglycan excretion in healthy subjects...
December 5, 2017: Anesthesiology
https://www.readbyqxmd.com/read/29192359/a-field-and-laboratory-study-of-the-responses-of-cytoprotection-and-osmoregulation-to-salinity-stress-in-mosquitofish-gambusia-affinis
#13
Jeng-Wei Tsai, Hon-Jung Liew, Jyun-Jiang Jhang, Shiou-Han Hung, Pei-Jie Meng, Ming-Yih Leu, Christopher Lim, Cheng-Hao Tang
The mosquitofish (Gambusia affinis) naturally inhabits freshwater (FW; 1-3‰) and seawater (SW; 28-33‰) ponds in constructed wetland. To explore the physiological status and molecular mechanisms for salinity adaptation of the mosquitofish, cytoprotective responses and osmoregulation were examined. In the field study, activation of protein quality control (PQC) mechanism through upregulation of the abundance of heat shock protein (HSP) 90 and 70 and ubiquitin-conjugated proteins was found in the mosquitofish gills from SW pond compared to the individuals of FW pond...
December 1, 2017: Fish Physiology and Biochemistry
https://www.readbyqxmd.com/read/29162060/long-term-prognosis-of-chronic-cough-a-prospective-observational-cohort-study
#14
Heikki O Koskela, Anne M Lätti, Minna K Purokivi
BACKGROUND: The long-term prognosis of chronic cough and its determinants need to be clarified. METHODS: This is a prospective, observational cohort study. Eighty-nine unselected subjects with chronic (> 8 weeks' duration) cough were carefully investigated: Clinical examination, symptom questionnaire, Leicester Cough Questionnaire (LCQ), skin prick tests, ambulatory peak expiratory flow monitoring, spirometry before and after 0.4 mgs of salbutamol, exhaled nitric oxide concentration measurement, hypertonic saline cough provocation test, and histamine bronchial provocation test...
November 21, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29137628/hypertonic-saline-for-prevention-of-delirium-in-geriatric-patients-who-underwent-hip-surgery
#15
Xi Xin, Fei Xin, Xuguang Chen, Qi Zhang, Yanan Li, Shuping Huo, Chongfu Chang, Qiujun Wang
BACKGROUND: Postoperative delirium (POD) is a common disorder in the elderly patients, and neuroinflammation is the possible underlying mechanism. This study is designed to determine whether or not hypertonic saline (HS) pre-injection can alleviate POD in aged patients. METHODS: This prospective study recruited 120 geriatric patients who underwent hip surgery. The patients were randomly divided into two groups: control group (NS group) and HS group. Patients in the NS group were pre-injected with 4 mL/kg isotonic saline, and those in the HS group were pre-injected with 4 mL/kg 7...
November 14, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29137091/the-effects-of-hypervolemic-infusion-on-microcirculation-perfusion-of-patients-during-laparoscopic-colorectal-surgery
#16
RANDOMIZED CONTROLLED TRIAL
Yunxin Deng, Qianlin Zhu, Buwei Yu, Minhua Zheng, Jue Jin
The aim of this study is to assess the effects of hypervolemic infusion with different solutions on microcirculation perfusion during laparoscopic colorectal surgery.Thirty-six patients were randomly divided into Ringer lactate solution [RL] group, succinylated gelatin injection [Gel] group, and hypertonic saline hydroxyethyl starch 40 injection [HS] group. Hypervolemic infusion was performed during the induction period of general anesthesia. Arterial blood-gas parameters, noninvasive hemodynamics, gastric tonometry values, and central venous pressure (CVP) were compared at baseline (T1); the end of hypervolemic infusion (T2); 5 min (T3), 15 min (T4), 30 min (T5), and 60 min (T6) during pneumoperitoneum; 5 min (T7), 15 min (T8), and 25 min (T9) after pneumoperitoneum...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29124569/running-based-pica-and-taste-avoidance-in-rats
#17
Sadahiko Nakajima
Running in an activity wheel generates pica behavior (kaolin clay intake) in rats. Wheel running also results in Pavlovian conditioned avoidance of the taste solution consumed immediately before the running. Since pica has been considered a behavioral marker of nausea in rats, these findings suggest that wheel running induces nausea, which is the underlying physiological state for establishing taste avoidance. This article reports a replication of running-based pica in rats (Experiment 1) and concurrent demonstrations of running-based pica and taste avoidance in the same animals (Experiments 2 and 3)...
November 9, 2017: Learning & Behavior
https://www.readbyqxmd.com/read/29081151/-effects-of-preconditioning-with-hypertonic-saline-solution-on-postoperative-delirium-in-the-aged
#18
X Xin, S P Huo, Q Zhang, Y N Li, L Wang, Q J Wang
Objective: To evaluate and explore the mechanism of the effect of hypertonic pre-injection on postoperative delirium in the aged. Methods: From June 2016 to February 2017, participants scheduled hip arthroplasty surgery were randomly divided into four groups: Group 1 (H1) 30 patients pre-injected 4 ml/kg hypertonic solution were proceeded general anesthesia; Group 2 (H2) 30 patients pre-injected 4 ml/kg hypertonic solution were proceeded spinal canal anesthesia; Group 3 (C1) 30 patients pre-injected 4 ml/kg isotonic saline were proceeded general anesthesia; Group 4 (C2) 30 patients pre-injected 4 ml/kg isotonic saline were proceeded spinal canal anesthesia in Department of Anesthesiology, Third Hospital of Hebei Medical University...
October 24, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28990478/changes-in-plasma-and-tissue-long-chain-polyunsaturated-fatty-acid-lc-pufa-content-in-the-eel-anguilla-japonica-after-external-and-internal-osmotic-stress
#19
Qinghao Zhang, Marty K S Wong, Yiqi Li, Yuanyou Li, Yoshio Takei
We investigated the effect of external and internal osmotic stress on the profile of long-chain polyunsaturated fatty acids (LC-PUFA) in euryhaline eels Anguilla japonica. Freshwater (FW) fish were transferred to seawater (SW) for external osmotic stress or subjected to internal stress through injection with hypertonic saline. FW eels injected with isotonic saline served as controls. Plasma osmolality, Na(+) concentration, and gill Na(+)/K(+) -ATPase activity increased, but hematocrit decreased compared with controls in eels exposed to external or internal osmotic stress...
October 2017: Zoological Science
https://www.readbyqxmd.com/read/28932357/effects-of-hypertonic-saline-solution-on-body-weight-and-serum-creatinine-in-patients-with-acute-decompensated-heart-failure
#20
Gabrielle Lafrenière, Patrick Béliveau, Jean-Yves Bégin, David Simonyan, Sylvain Côté, Valérie Gaudreault, Zeev Israeli, Shahar Lavi, Rodrigo Bagur
AIM: To test the safety and effectiveness of hypertonic saline solution (HSS + F) as a strategy for weight loss and prevention of further deterioration of renal function. METHODS: Patients admitted with acute decompensated heart failure (ADHF) who received HSS + F were included in the study. After a period of a standard ADHF treatment, our patients received an intravenous infusion of furosemide (250 mg) combined with HSS (150 mL of 3% NaCl) twice a day for a mean duration of 2...
August 26, 2017: World Journal of Cardiology
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