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JOURNAL ARTICLE
Magdalena Wigger, Marco Schneider, Anni Feldmann, Sonja Assenmacher, Branko Zevnik, Simon E Tröder
OBJECTIVE: The ever-increasing number of genetically engineered mouse models highlights the need for efficient archiving and distribution of these lines. Sperm cryopreservation has become the preferred technique for the majority of these models due to its low requirement of costs, time, and experimental animals. Yet, current in vitro fertilization (IVF) protocols either exhibit decreased fertilization efficiency for the most popular C57BL/6 strain, as recently demonstrated by us, or require costly and difficult-to-prepare media, respectively...
August 24, 2023: BMC Research Notes
#22
JOURNAL ARTICLE
D Romualdi, B Ata, S Bhattacharya, E Bosch, M Costello, K Gersak, R Homburg, M Mincheva, R J Norman, T Piltonen, S Dos Santos-Ribeiro, D Scicluna, S Somers, S K Sunkara, H R Verhoeve, N Le Clef
STUDY QUESTION: What is the recommended management for couples presenting with unexplained infertility (UI), based on the best available evidence in the literature? SUMMARY ANSWER: The evidence-based guideline on UI makes 52 recommendations on the definition, diagnosis, and treatment of UI. WHAT IS KNOWN ALREADY: UI is diagnosed in the absence of any abnormalities of the female and male reproductive systems after 'standard' investigations...
October 3, 2023: Human Reproduction
#23
JOURNAL ARTICLE
Stefano Palomba, Domenico Carone, Amerigo Vitagliano, Flavia Costanzi, Alice Fracassi, Tiziana Russo, Serena Del Negro, Altiero Biello, Aldo Di Filippo, Antonio Mangiacasale, Antonio Monaco, Antonio Ranieri, Beatrice Ermini, Bruno Francesco Barba, Claudio Castello, Federica Di Guardo, Francesco Pastorella, Elena Bernasconi, Ezio Michele Tricarico, Francesca Filippi, Francesco Polsinelli, Giuseppe Lo Monte, Loredana M Sosa Fernandez, Marco Galletta, Paolo Giardina, Pasquale Totaro, Roberto Laganara, Roberto Liguori, Matteo Buccheri, Mario Montanino Oliva, Rosita Piscopo, Assunta Iuliano, Nicola Innantuoni, Irene Romanello, Francesco Sinatra, Annalisa Liprino, Roberto Thiella, Alessandra Tiezzi, Tiziana Bartolotti, Alessandra Tomasi, Valeria Finocchiaro, Mario Thiella, Giuseppa Fuggetta, Sebastiano Messineo, Francesco Isabella, Marcello Tripodi, Stefania Iaccarino, Giovanni Battista La Sala, Enrico Papaleo, Donatella Caserta, Roberto Marci, Edgardo Somigliana, Antonino Guglielmino
BACKGROUND: Endometrial scratching (ES) or injury is intentional damage to the endometrium performed to improve reproductive outcomes for infertile women desiring pregnancy. Moreover, recent systematic reviews with meta-analyses and randomized controlled trials demonstrated that ES is not effective, data on the safety are limited, and it should not be recommended in clinical practice. The aim of the current study was to assess the view and behavior towards ES among fertility specialists throughout infertility centers in Italy, and the relationship between these views and the attitudes towards the use of ES as an add-on in their commercial setting...
July 29, 2023: BMC Women's Health
#24
JOURNAL ARTICLE
Weiwei Zou, Kai Zong, Zhikang Zhang, Lingchao Shen, Xiaolei Wang, Xun Su, Xin Wang, Tao Yin, Chunmei Liang, Yajing Liu, Dan Liang, Chao Hu, Yunxia Cao, Dongmei Ji
PURPOSE: Although a variety of analytical methods have been developed to detect mitochondrial DNA (mtDNA) heteroplasmy, there are special requirements of mtDNA heteroplasmy quantification for women carrying mtDNA mutations receiving the preimplantation genetic diagnosis (PGD) and prenatal diagnosis (PD) in clinic. These special requirements include various sample types, large sample number, long-term follow-up, and the need for detection of single-cell from biopsied embryos. Therefore, developing an economical, accurate, high-sensitive, and single-cell analytical method for mtDNA heteroplasmy is necessary...
July 18, 2023: Journal of Assisted Reproduction and Genetics
#25
JOURNAL ARTICLE
Selwyn P Oskowitz, Angélique K Rwiyereka, Théogène Rurangwa, Donald S Shepard, Emile Rwamasirabo, Keith B Isaacson, Sheryl van der Poel, Catherine Racowsky
OBJECTIVE: To describe the initiation, integration, and costs of reduced-cost infertility services within the maternal health department of a public hospital in a low-income country. DESIGN: Retrospective review of the clinical and laboratory components of patients undergoing in vitro fertilization (IVF) treatment in Rwanda from 2018 to 2020. SETTING: Academic tertiary referral hospital in Rwanda. PATIENTS: Patients seeking infertility services beyond the primary gynecological options...
June 2023: F&S reports
#26
JOURNAL ARTICLE
Austin G Armstrong, Maggie Woods, Jennifer Keomany, David Grainger, Shriya Shah, MaryEllen Pavone
PURPOSE: This study aimed to assess medical student knowledge and attitudes regarding oocyte cryopreservation, as well as attitudes regarding future intentions of utilizing this procedure. METHODS: This cross-sectional web-based survey study was distributed to 873 medical students at the University of Kansas from July through September 2018. The survey was self-reported and female medical student responses were analyzed. Students were surveyed through a variety of multiple-choice questions on demographics, knowledge of oocyte cryopreservation, and factors and attitudes that would impact personal and professional use of oocyte cryopreservation...
June 22, 2023: Journal of Assisted Reproduction and Genetics
#27
JOURNAL ARTICLE
I Elkhatib, D Nogueira, A Bayram, A Abdala, R Del Gallego, L Melado, N De Munck, B Lawrenz, H Fatemi
STUDY QUESTION: Which patients might benefit from insemination of delayed-matured oocytes? SUMMARY ANSWER: Delayed-matured oocytes had a ≥50% contribution to the available cohort of biopsied blastocysts in patients with advanced maternal age, low maturation, and/or low fertilization rates. WHAT IS KNOWN ALREADY: Retrieved immature oocytes that progress to the MII stage in vitro could increase the number of embryos available during ICSI cycles...
August 1, 2023: Human Reproduction
#28
JOURNAL ARTICLE
May-Tal Sauerbrun-Cutler, Sonali Pandya, Olivia Recabo, Christina Raker, Melissa A Clark, Katina Robison
PURPOSE: To identify the proportion of reproductive age women with breast cancer that engaged in a fertility preservation discussion and reproductive endocrinology and infertility (REI) consultation. METHODS: This cross-sectional survey recruited women 18-42 years who were diagnosed with breast cancer from 2006 to 2016 by phone or email and asked them to complete an online survey. Demographic characteristics, barriers to FP, utilization of FP consultation, and FP procedures (oocyte and embryo cryopreservation) were analyzed...
June 17, 2023: Journal of Assisted Reproduction and Genetics
#29
JOURNAL ARTICLE
Willem Ombelet, Régine Goemaes, Elizaveta Fomenko, Rudi Campo
BACKGROUND: We developed a simplified IVF culture system (SCS) which has proven to be effective and safe in a selected IVF cohort. METHODS: Preterm birth (PTB) and low birth weight (LBW) of 175 singletons born after using the SCS, 104 after fresh embryo transfer (ET), and 71 after frozen embryo transfer, were compared with all singletons born in Flanders between 2012 and 2020 conceived after natural conception, ovarian stimulation (OS), and assisted reproduction (IVF/ICSI)...
May 26, 2023: Journal of Clinical Medicine
#30
JOURNAL ARTICLE
Giovanni Ceschia, Apaara K Chawla, Jolyn Morgan, James E Rose, Stuart L Goldstein, Denise C Hasson
BACKGROUND: Acute kidney injury is a cause of preventable deaths in low resource settings due to lack of dialysis access and cost. A manual single lumen alternating micro-batch (mSLAMB) dialysis technique performs kidney replacement therapy using single lumen access, low-cost bags/tubing, intravenous fluids, and a filter without electricity, a battery, or a pump. We propose a protocol whereby mSLAMB can perform diffusive clearance simply and efficiently to bring dialysis to underserved populations...
May 13, 2023: Pediatric Research
#31
JOURNAL ARTICLE
An Algorithm to Predict the Lack of Pregnancy after Intrauterine Insemination in Infertile Patients.
Emma Garcia-Grau, Mario Oliveira, Maria José Amengual, Encarna Rodriguez-Sanchez, Ana Veraguas-Imbernon, Laura Costa, Jordi Benet, Jordi Ribas-Maynou
Increasing intrauterine insemination (IUI) success rates is essential to improve the quality of care for infertile couples. Additionally, straight referral of couples with less probability of achieving a pregnancy through IUI to more complex methods such as in vitro fertilization is important to reduce costs and the time to pregnancy. The aim of the present study is to prospectively evaluate the threshold values for different parameters related to success in intrauterine insemination in order to provide better reproductive counseling to infertile couples, moreover, to generate an algorithm based on male and female parameters to predict whether the couple is suitable for achieving pregnancy using IUI...
April 30, 2023: Journal of Clinical Medicine
#32
RANDOMIZED CONTROLLED TRIAL
Sunita Sharma, Sourav RoyChoudhury, M Padmaja Bhattacharya, Shubhendu Hazra, Arup Kumar Majhi, Kamal C Oswal, Ratna Chattopadhyay
RESEARCH QUESTION: Can low-dose letrozole reduce dysmenorrhoea, menorrhagia and sonographic features in symptomatic women with adenomyosis awaiting IVF? DESIGN: This was a longitudinal randomized prospective pilot study to explore the effectiveness of low-dose letrozole and compare it with a gonadotropin releasing hormone (GnRH) agonist in reducing dysmenorrhoea, menorrhagia and sonographic features in symptomatic women with adenomyosis awaiting IVF. The women were treated for 3 months, either with the GnRH agonist goserelin 3...
July 2023: Reproductive Biomedicine Online
#33
Yao Xie, Lesang Li, Le Xie, Junlin Jiang, Ting Yao, Guo Mao, Shiliang Wang, Anchao Lin, Jinwen Ge, Dahua Wu
Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is an immune-mediated neuropathy. First-line treatments for CIDP include corticosteroids, intravenous immunoglobulin, and plasma exchange. However, the application is always limited by high costs, effectiveness, and adverse events. This study investigated a new potentially effective and safe therapeutic treatment to alleviate CIDP symptoms and improve the quality of life. In the present case, a 47-year-old rural woman presented with weakness and numbness of progressive extremities...
2023: Frontiers in Neurology
#34
JOURNAL ARTICLE
Sue Sleiman, Feyrous Bacha, David J Handelsman
SUMMARY: We report the successful delivery of a healthy baby after intracytoplasmic sperm injection (ICSI) with frozen-thawed autologous sperm, cryostored for 26 years, the longest successful autologous sperm cryostorage reported. Sperm was cryostored for a 15-year-old boy at the time of his cancer diagnosis. Semen samples were frozen with cryoprotectant, using a graduated vapour-phase nitrogen protocol. Straws were stored in a large vapour-phase nitrogen tank until transfer for use. The couple underwent a single ICSI-in vitro fertilisation procedure using the frozen-thawed sperm with a transfer of five fertilised embryos, resulting in the live birth of a healthy baby boy...
April 1, 2023: Endocrinology, Diabetes & Metabolism Case Reports
#35
JOURNAL ARTICLE
Rajendran Lakshmi Priya, Bheeranna Kariyanna, Sengodan Karthi, Raja Sudhakaran, Sundaram Ganesh Babu, Radhakrishnan Vidya
The active and inexpensive catalyst cupric oxide (CuO) loaded foliar fertilizer of graphitic carbon nitride ( g -C3 N4 ) is investigated for biological applications due to its low cost and easy synthesis. The synthesized CuO NPs, bulk g-C3 N4 , exfoliated g -C3 N4 , and different weight percentages of 30 wt%, 40 wt%, 50 wt%, 60 wt%, and 70 wt% CuO-loaded g -C3 N4 are characterized using different analytical techniques, including powder X-ray diffraction, scanning electron microscopy, energy dispersive X-ray analysis, and ultraviolet-visible spectroscopy...
February 28, 2023: Journal of Fungi (Basel, Switzerland)
#36
JOURNAL ARTICLE
Willem Ombelet, Jonathan Van Blerkom, Liesbeth Bruckers, Nathalie Dhont, Geeta Nargund, Rudi Campo
BACKGROUND: Assisted reproductive techniques services are often not accessible to the majority of infertile couples in Low and Middle Income Countries (LMIC) due to high costs. Lowering IVF laboratory costs is a crucial step to make IVF affordable for a larger part of the world population. We developed a simplified culture system (SCS) which has proven to be effective, and the next step is to prove its safety. METHODS: Preterm birth (PTB) and low birthweight (LBW) of 176 singletons born after using the SCS, 105 after fresh embryo transfer (fresh ET), and 71 after frozen embryo transfer (frozen ET) were compared with all IVF/ICSI singletons born in Belgium between 2013 and 2018...
March 15, 2023: Journal of Clinical Medicine
#37
JOURNAL ARTICLE
Purity Njagi, Wim Groot, Jelena Arsenijevic, Silke Dyer, Gitau Mburu, James Kiarie
STUDY QUESTION: What are the direct costs of assisted reproductive technology (ART), and how affordable is it for patients in low- and middle-income countries (LMICS)? SUMMARY ANSWER: Direct medical costs paid by patients for infertility treatment are significantly higher than annual average income and GDP per capita, pointing to unaffordability and the risk of catastrophic expenditure for those in need. WHAT IS KNOWN ALREADY: Infertility treatment is largely inaccessible to many people in LMICs...
2023: Human Reproduction Open
#38
L Vu Tan, N Phuc Cam Hoang, M Ba Tien Dung, P Vinh Phu, M Martinez, N Minh Duc
BACKGROUND: This study evaluated whether microsurgical varico-celectomy performed in infertile men with severe oligozoospermia (SO) resulted in improved semen parameters or increased rates of spontaneous pregnancy (SP) and performed a cost-effectiveness analysis comparing intrauterine insemination (IUI), in vitro fertilization (IVF), and varicocelectomy. METHODS: This study included 25 patients with SO who underwent microsurgical varicocelectomy between September 2019 and May 2022, which resulted in post-surgical SP in all cases...
2023: La Clinica Terapeutica
#39
JOURNAL ARTICLE
Pasquale Petrone, Alberto Vaiarelli, Christophe Blockeel
PURPOSE OF REVIEW: The technical improvements in IVF allowed the implementation of nonconventional ovarian stimulation protocols for some specific patients. Where time is crucial, such as with oncologic patients, poor-prognosis patients, patients with low ovarian reserve, and those with advanced maternal age, access to IVF treatment is even more critical. Some of these protocols might start in the late follicular phase, luteal phase, or involve both stimulations within the same ovarian cycle...
March 7, 2023: Current Opinion in Obstetrics & Gynecology
#40
JOURNAL ARTICLE
Teeranan Pokaprakarn, Juan C Prieto, Joan T Price, Margaret P Kasaro, Ntazana Sindano, Hina R Shah, Marc Peterson, Mutinta M Akapelwa, Filson M Kapilya, Yuri V Sebastião, William Goodnight, Elizabeth M Stringer, Bethany L Freeman, Lina M Montoya, Benjamin H Chi, Dwight J Rouse, Stephen R Cole, Bellington Vwalika, Michael R Kosorok, Jeffrey S A Stringer
BACKGROUND: Ultrasound is indispensable to gestational age estimation and thus to quality obstetrical care, yet high equipment cost and the need for trained sonographers limit its use in low-resource settings. METHODS: From September 2018 through June 2021, we recruited 4695 pregnant volunteers in North Carolina and Zambia and obtained blind ultrasound sweeps (cineloop videos) of the gravid abdomen alongside standard fetal biometry. We trained a neural network to estimate gestational age from the sweeps and, in three test data sets, assessed the performance of the artificial intelligence (AI) model and biometry against previously established gestational age...
May 2022: NEJM Evid
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