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https://www.readbyqxmd.com/read/29332427/serum-potassium-levels-and-outcomes-in-critically-ill-patients-in-the-medical-intensive-care-unit
#1
Surat Tongyoo, Tanuwong Viarasilpa, Chairat Permpikul
Objective To compare the outcomes of patients with and without a mean serum potassium (K+) level within the recommended range (3.5-4.5 mEq/L). Methods This prospective cohort study involved patients admitted to the medical intensive care unit (ICU) of Siriraj Hospital from May 2012 to February 2013. The patients' baseline characteristics, Acute Physiology and Chronic Health Evaluation II (APACHE II) score, serum K+ level, and hospital outcomes were recorded. Patients with a mean K+ level of 3.5 to 4.5 mEq/L and with all individual K+ values of 3...
January 1, 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/29331435/complications-of-chronic-total-occlusion-percutaneous-coronary-intervention-subepicardial-hematoma
#2
Punag Divanji, Kendrick Shunk
A 67-year-old man with coronary artery disease and previous coronary underwent successful Guideliner reverse CART percutaneous coronary intervention of a chronic total occlusion of the right coronary artery. He later developed evidence of myocardial ischemia, and imaging, including angiogram, echocardiogram, and cardiac computed tomography revealing active dye extravasation from the previously normal RV marginal branches, in addition to a large subepicardial hematoma. Despite these dramatic findings, the patient remained hemodynamically stable and pain-free, with resolving ECG changes...
December 30, 2017: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/29328848/high-risk-endovascular-aneurysm-repair-a-case-report
#3
Samanthi De Silva
Mr AB is a 66-year old gentleman who presented for elective endovascular aneurysm repair (EVAR) following a routine screening scan identifying a 5.5cm abdominal aortic aneurysm (AAA). He had a past history of chronic obstructive pulmonary disease (COPD) with FEV1/FVC ratio of 48% on pre-assessment. He was hypertensive with a history of ischaemic heart disease (IHD), which has remained asymptomatic following coronary artery bypass grafting (CABG) eight years prior to this presentation.
October 2017: Journal of Perioperative Practice
https://www.readbyqxmd.com/read/29327345/serum-lipoprotein-a-predicts-acute-coronary-syndromes-in-patients-with-severe-carotid-stenosis
#4
Fabio Rigamonti, Federico Carbone, Fabrizio Montecucco, Aldo Bonaventura, Luca Liberale, Fabienne Burger, Aline Roth, Maria Bertolotto, Giovanni Spinella, Bianca Pane, Domenico Palombo, Aldo Pende, Franco Dallegri, François Mach, Stefano Bertolini, Livia Pisciotta
Different cut-off values of serum lipoprotein(a) [Lp(a)] were recently identified in order to better stratify cardiovascular risk categories. Both pathophysiological and prognostic values of Lp(a) remain unclear. Here, the prognostic value of Lp(a) and its correlation with intraplaque features were assessed in patients with severe carotid artery stenosis undergoing endarterectomy (n=180). The cut-off value of 10 mg/dL for serum Lp(a) was selected to predict 24-month follow-up acute coronary syndrome (ACS). In addition, the association between serum Lp(a) and intraplaque lipids, collagen, inflammatory and vascular cells was assessed...
January 11, 2018: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29326773/clinical-outcomes-of-patients-undergoing-rotational-atherectomy-followed-by-drug-eluting-stent-implantation-a-single-center-real-world-experience
#5
Lucky R Cuenza, Ada Cherryl Jayme, James Ho Khe Sui
Background: Rotational atherectomy (RA) is used to improve procedural success of percutaneous catheter interventions (PCIs) of complex and heavily calcified coronary lesions. We report the clinical experience and outcomes in our institution with the use of RA, followed by drug-eluting stent implantation. Materials and Methods: Data of 81 patients treated with PCI and adjunctive RA were analyzed. Clinical follow-up for the occurrence of major adverse events (MAEs) was obtained in all patients and correlated with significant variables using multivariate Cox proportional hazards analysis...
October 2017: Heart Views: the Official Journal of the Gulf Heart Association
https://www.readbyqxmd.com/read/29310598/assessing-cardiovascular-risk-in-chronic-kidney-disease-patients-prior-to-kidney-transplantation-clinical-usefulness-of-a-standardised-cardiovascular-assessment-protocol
#6
Robin Ramphul, Maria Fernandez, Sam Firoozi, Juan C Kaski, Rajan Sharma, Debasish Banerjee
BACKGROUND: Despite pre-kidney-transplant cardiovascular (CV) assessment being routine care to minimise perioperative risk, the utility of such assessment is not well established. The study reviewed the evaluation and outcome of a standardised CV assessment protocol. METHODS: Data were analysed for 231 patients (age 53.4 ± 12.9 years, diabetes 34.6%) referred for kidney transplantation between 1/2/2012-31/12/2014. One hundred forty-three patients were high-risk (age > 60 years, diabetes, CV disease, heart failure, peripheral vascular disease) and offered dobutamine stress echocardiography (DSE); 88 patients were low-risk and offered ECG and echocardiography with/without exercise treadmill test...
January 8, 2018: BMC Nephrology
https://www.readbyqxmd.com/read/29305561/trends-in-cardiovascular-risk-factor-and-disease-prevalence-in-patients-undergoing-non-cardiac-surgery
#7
Nathaniel R Smilowitz, Navdeep Gupta, Yu Guo, Joshua A Beckman, Sripal Bangalore, Jeffrey S Berger
OBJECTIVES: Cardiovascular risk factors are prevalent in the population undergoing non-cardiac surgery. Changes in perioperative cardiovascular risk factor profiles over time are unknown. The objective of this study was to evaluate national trends in cardiovascular risk factors and atherosclerotic cardiovascular disease (ASCVD) among patients undergoing non-cardiac surgery. METHODS: Adults aged ≥45 years old who underwent non-cardiac surgery were identified using the US National Inpatient Sample from 2004 to 2013...
January 5, 2018: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29301644/sex-specific-outcomes-of-transcatheter%C3%A2-aortic-valve-replacement-with-the-sapien-3-valve-insights-from-the-partner-ii-s3-high-risk-and-intermediate-risk-cohorts
#8
Molly Szerlip, Sarah Gualano, Elizabeth Holper, John J Squiers, Jonathon M White, Darshan Doshi, Mathew R Williams, Rebecca T Hahn, John G Webb, Lars G Svensson, Ajay J Kirtane, David J Cohen, Pamela S Douglas, Maria C Alu, Aaron Crowley, E Murat Tuzcu, Raj R Makkar, Howard C Herrmann, Vasilis Babaliaros, Vinod H Thourani, Martin B Leon, Susheel K Kodali, Michael J Mack
OBJECTIVES: The purpose of this study was to identify sex-specific outcomes of intermediate risk patients undergoing transcatheter aortic valve replacement with the SAPIEN 3 valve. BACKGROUND: A survival difference has been observed in women as compared with men in inoperable and high-risk patients receiving early-generation balloon-expandable valves for transcatheter aortic valve replacement (TAVR). Whether a sex-specific outcome difference persists with newer-generation valves and in lower-risk patients is unknown...
January 8, 2018: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29299849/lipid-management-in-chronic-kidney-disease-systematic-review-of-pcsk9-targeting
#9
REVIEW
BinBin Zheng-Lin, Alberto Ortiz
Cardiovascular disease is the leading cause of death in patients with chronic kidney disease (CKD) and CKD is considered a coronary artery disease risk equivalent. So far, statins have been the mainstay of primary and secondary prevention of cardiovascular disease in the general population. However, their benefit on outcomes is limited and controversial in CKD patients and new therapeutic approaches to reduce cardiovascular risk are needed. Monoclonal antibodies targeting proprotein convertase subtilisin/kexin 9 (PCSK9) reduce low-density lipoprotein cholesterol (LDL-C) and lipoprotein(a) in high-risk populations and cardiovascular events in secondary prevention...
January 3, 2018: Drugs
https://www.readbyqxmd.com/read/29297057/association-of-cardiovascular-risk-with-inhaled-long-acting-bronchodilators-in-patients-with-chronic-obstructive-pulmonary-disease-a-nested-case-control-study
#10
Meng-Ting Wang, Jun-Ting Liou, Chen Wei Lin, Chen-Liang Tsai, Yun-Han Wang, Yu-Juei Hsu, Jyun-Heng Lai
Importance: The associations between cardiovascular disease (CVD) and inhaled long-acting β2-agonists (LABAs) or long-acting antimuscarinic antagonists (LAMAs) in chronic obstructive pulmonary disease (COPD) are greatly debated. Pivotal and relevant randomized clinical trials included prior LABA or LAMA users and excluded patients with baseline CVD; therefore, cardiovascular events arising from first-time LABA or LAMA use, if any, could not be observed. There is an urgent need to examine whether new use of and duration since initiating LABAs and LAMAs could act as important determinants of cardiovascular events...
January 2, 2018: JAMA Internal Medicine
https://www.readbyqxmd.com/read/29289574/long-term-clinical-impact-of-serum-albumin-in-coronary-artery-disease-patients-with-preserved-renal-function
#11
H Wada, T Dohi, K Miyauchi, J Shitara, H Endo, S Doi, H Konishi, R Naito, S Tsuboi, M Ogita, T Kasai, A Hassan, S Okazaki, K Isoda, S Suwa, H Daida
BACKGROUND AND AIMS: Low serum albumin level is reportedly associated with worse clinical outcomes in patients with chronic kidney disease (CKD). However, associations between decreased serum albumin level and outcomes in non-CKD patients with coronary artery disease (CAD) remain unclear. Therefore, we aimed to evaluate the prognostic value of serum albumin concentrations in stable CAD patients with preserved renal function. METHODS AND RESULTS: We studied 1316 patients with CAD and preserved renal function (estimated glomerular filtration rate ≥60 mL/min/1...
November 26, 2017: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/29286988/cardiovascular-and-metabolic-morbidity-after-hysterectomy-with-ovarian-conservation-a-cohort-study
#12
Shannon K Laughlin-Tommaso, Zaraq Khan, Amy L Weaver, Carin Y Smith, Walter A Rocca, Elizabeth A Stewart
OBJECTIVE: The aim of the study was to determine the long-term risk of cardiovascular disease and metabolic conditions in women undergoing hysterectomy with bilateral ovarian conservation compared with age-matched referent women. METHODS: Using the Rochester Epidemiology Project records-linkage system, we identified 2,094 women who underwent hysterectomy with ovarian conservation for benign indications between 1980 and 2002 in Olmsted County, Minnesota. Each woman was age-matched (±1 y) to a referent woman residing in the same county who had not undergone prior hysterectomy or any oophorectomy...
December 28, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/29284990/the-impact-of-risk-factors-and-comorbidities-on-the-incidence-of-atrial-fibrillation
#13
Nabil Naser, Mirza Dilic, Azra Durak, Mehmed Kulic, Esad Pepic, Elnur Smajic, Zumreta Kusljugic
Introduction: Atrial fibrillation (AF) is the most common form of cardiac arrhythmia in clinical practice and its prevalence increases with age. Patients who develop AF also have cardiovascular risk factors, structural heart disease, and comorbidities, all of which can increase mortality. AF causes a significant economic burden with the increasing trend in AF prevalence and hospitalizations. Research Objectives: The objective of our study is to evaluate the impact of the most common known risk factors on the incidence of atrial fibrillation as an important precursor of cardiac and cerebrovascular morbidity and mortality among our patients in Bosnia and Herzegovina during median follow up period (September 2006 - September 2016)...
December 2017: Materia Socio-medica
https://www.readbyqxmd.com/read/29283057/advanced-strategies-in-the-diagnosis-and-treatment-of-patients-with-coronary-artery-disease-and-heart-failure-when-heart-failure-causes-ischemia-and-angiotensin-converting-enzyme-inhibitor-and-betablockers-helps-in-diuresis
#14
Thach Nguyen, Nguyen Van Lanh, Vo Minh Viet, Lam Hoang Phuc, Trung N Pham, Khanh Duong, Luke Ashwin Lawrence, Vien T Truong, Gianluca Rigatelli
In the diagnosis and management of patients with coronary artery disease (CAD) and chronic left ventricular (LV) dysfunction or heart failure (HF), there are many uncertainties because of the non-specificity of the symptoms and signs of HF. Usually, severe CAD causes LV dysfunction. However, not rarely, LV dysfunction is the cause or aggravation of ischemia to many subsets of patients with or without CAD. In this article, the care of patients with CAD with LV dysfunction, along with the challenges of diagnosing asymptomatic HF and the criteria for monitoring success are presented...
December 27, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29281559/left-atrial-abnormality-laa-as-a-predictor-of-ibrutinib-associated-atrial-fibrillation-in-patients-with-chronic-lymphocytic-leukemia
#15
Anthony R Mato, Suparna Clasen, Peter Pickens, Lisa Gashonia, Joanna Rhodes, Jakub Svoboda, Mitchell Hughes, Chadi Nabhan, Naveed Ali, Stephen Schuster, Joseph Carver
Results from several recent studies in chronic lymphocytic leukemia (CLL) have demonstrated an association between ibrutinib exposure and the development of atrial fibrillation, estimated incidence of 11% with long-term follow up. This is a common cause of ibrutinib discontinuation. Risk factors for atrial fibrillation include advanced age, hypertension (HTN), mitral valve disease (MVD), left atrial remodeling, coronary artery disease (CAD) and risk factors for cardiovascular dysfunction We conducted a retrospective case control study using the presence of left atrial abnormality identified on pre-ibrutinib EKGs, defined as either (1) Lead II-bifed p wave, with 40 mcsec between peaks for ≥ 2...
December 27, 2017: Cancer Biology & Therapy
https://www.readbyqxmd.com/read/29280914/anemia-and-coronary-artery-disease-pathophysiology-prognosis-and-treatment
#16
Jennifer A Rymer, Sunil V Rao
The mechanisms, pathophysiology, and treatment of anemia in coronary artery disease (CAD) are complex. The hemodynamic changes found in the acute anemic state may contribute to progressive arterial wall and left ventricular hypertrophy if the anemic state persists chronically. We will examine the evidence for anemia as an independent risk factor for CAD events and cardiovascular mortality after percutaneous coronary intervention. We will also investigate the thresholds for appropriate blood transfusion in patients with CAD, as well as the cardiovascular outcomes associated with the utilization of a liberal versus conservative blood transfusion strategy...
December 26, 2017: Coronary Artery Disease
https://www.readbyqxmd.com/read/29279041/exercise-through-a-cardiac-rehabilitation-program-attenuates-oxidative-stress-in-patients-submitted-to-coronary-artery-bypass-grafting
#17
José Francisco Taty Zau, Rodrigo Costa Zeferino, Nádia Sandrine Mota, Gerez Fernandes Martins, Salvador Manoel Serra, Therezil Bonates da Cunha, Daniel Medeiros Lima, Basilio de Bragança Pereira, Emília Matos do Nascimento, Danilo Wilhelm Filho, Rozangela Curi Pedrosa, Roberto Coury Pedrosa
BACKGROUND: Cardiovascular disease is the main cause of morbidity and mortality in the world and oxidative stress has been implicated in the pathogenesis. Cardiac rehabilitation in patients with coronary artery disease submitted to coronary artery bypass grafting may prevent cardiovascular events probably through the attenuation of oxidative stress. The aim of this study was to evaluate the benefits of a cardiac rehabilitation program in the control of the systemic oxidative stress. METHODS: The studied population consisted of 40 patients, with chronic stable coronary artery disease submitted to coronary artery bypass grafting, who attended a cardiac rehabilitation program...
December 27, 2017: Redox Report: Communications in Free Radical Research
https://www.readbyqxmd.com/read/29277382/prevalence-of-chronic-comorbidities-in-chikungunya-a-systematic-review-and-meta-analysis
#18
Alaa Badawi, Seung Gwan Ryoo, Danitsa Vasileva, Sahar Yaghoubi
BACKGROUND: Epidemiologic evidence suggests that patients with chikungunya virus (CHIKV) infection may be at risk of severe disease complications when they also have comorbidities such as obesity, diabetes, cardiac diseases, and/or asthma. However, the prevalence of these co-existing medical conditions in severe CHIKV cases has not been systematically reported. OBJECTIVE: The aim of the present study is to conduct a systematic review and meta-analysis to describe the prevalence of chronic comorbidities in CHIKV and evaluate their possible contributions to disease severity...
December 19, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/29276927/-prognostic-value-of-melatonin-level-structural-and-functional-changes-of-the-myocardium-in-the-development-of-complications-in-patients-with-heart-failure-who-underwent-coronary-artery-bypass-grafting-the-possibilities-of-pharmacological-cardioprotection
#19
S P Salikova, Y V Liskova, A A Stadnikov, S A Selivanov, N B Tverdokhlib, V O Rozhkov, G M Avchenko, A Y Erkhov, A B Popov
OBJECTIVE: To assess the significance of melatonin, NT-proBNP and morphological markers of myocardial remodeling for predicting the risk of complications after coronary artery bypass grafting (CABG) in patients with ischemic heart disease and chronic heart failure (CHF). MATERIALS AND METHODS: We included in this study 83 patients who underwent CABG in the period from September 2013 to October 2014. All patients before CABG underwent standard laboratory and instrumental examination...
October 2017: Kardiologiia
https://www.readbyqxmd.com/read/29275882/dysfunctional-uterine-activity-in-labour-and-premature-adverse-cardiac-events-population-based-cohort-study
#20
Alyssa Kahane, Alison L Park, Joel G Ray
BACKGROUND: There exist structural and physiological commonalities between myometrial and myocardial tissue, and each can become dysfunctional, such as in the presence of cardiometabolic factors. METHODS: This population-based cohort study was comprised of 1,608,720 women with ≥ 1 singleton hospital live birth at 24-41 weeks' gestation in Ontario, from 1992 to 2016. The main exposure was prolonged first stage of labour; secondary exposure was prolonged second stage of labour...
January 2018: Canadian Journal of Cardiology
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